481:
458:
40:
1451:
31:
2179:
762:
characterized by poor coordination, numbness, and decreased sensation to touch, temperature, and vibration. Healthy human blood levels of pyridoxine are 2.1–21.7 ng/mL. Normal doses are safe during
1295:
intake in relation to tolerable upper intake levels. Opinion of the Panel on
Nutrition, Dietetic Products, Novel Food and Allergy of the Norwegian Scientific Committee for Food Safety
2209:
153:
758:
It is usually well tolerated, though overdose toxicity is possible. Occasionally side effects include headache, numbness, and sleepiness. Pyridoxine overdose can cause a
826:
is in range of 25 to 33 days. After considering the different sources, it can be concluded that the half-life of pyridoxine is typically measured in several weeks.
1328:
Eighty to ninety percent of vitamin B6 in the body is found in muscles and estimated body stores in adults amount to about 170 mg with a half-life of 25-33 days.
67:
1289:
571:
739:
alleviates the numbness. Pyridoxine-dependent epilepsy is a type of rare infant epilepsy that does not improve with typical anti-seizure medications.
938:
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1306:
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991:
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It is usually well tolerated. Occasionally side effects include headache, numbness, and sleepiness. Normal doses are safe during
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104:
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The half-life of pyridoxine varies according to different sources: one source suggests that the half-life of
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141:
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732:
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633:
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1168:"Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials"
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807:. It is also required for muscle phosphorylase activity associated with glycogen metabolism.
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Lheureux P, Penaloza A, Gris M (April 2005). "Pyridoxine in clinical toxicology: a review".
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843:
747:
493:
222:
366:
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Pyridoxine was discovered in 1934, isolated in 1938, and first made in 1939. It is on the
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The Role of Food, Agriculture, Forestry and
Fisheries in Human Nutrition - Volume IV
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Anh NH, Kim SJ, Long NP, Min JE, Yoon YC, Lee EG, et al. (January 2020).
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World Health
Organization model list of essential medicines: 21st list 2019
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1019:"Office of Dietary Supplements - Dietary Supplement Fact Sheet: Vitamin B6"
22:
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99:
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30:
2029:
2016:
1946:
931:"Pyridoxine 50mg Tablets - Summary of Product Characteristics (SmPC)"
792:
676:
417:
699:
As a treatment (oral or injection), it is used to treat or prevent
599:
InChI=1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3
386:
796:
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537:
397:
1485:
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94:
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is up to 20 days, while another source indicates half-life of
667:
family of vitamins. It is required by the body to metabolise
442:
148:
By mouth, intravenous (IV), intramuscular (IM), subcutaneous
126:
1435:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
836:
783:
family of vitamins. It is required by the body to make
869:"Electrochemistry of Biologically Important Pyridines"
2167:
1385:. Springer Science & Business Media. p. 39.
1051:. The American Society of Health-System Pharmacists.
990:. The American Society of Health-System Pharmacists.
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628:. As a supplement it is used to treat and prevent
305:
280:
2210:World Health Organization essential medicines
1501:
1274:The half-life of pyridoxine is up to 20 days.
1250:Kennedy A, Schaeffer T (2016). "Pyridoxine".
8:
1119:"Management of pediatric status epilepticus"
103:
21:
982:
980:
978:
976:
263:4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol
1854:
1627:Calcitriol (1,25-dihydroxycholecalciferol)
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850:have pyridoxine added in some countries.
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873:Electrochemistry of Biological Molecules
2174:
859:
652:. It is used by mouth or by injection.
596:
576:
563:159 to 162 °C (318 to 324 °F)
452:
325:
260:
1123:Current Treatment Options in Neurology
1117:Abend NS, Loddenkemper T (July 2014).
1076:European Journal of Emergency Medicine
889:from the original on 30 December 2016.
470:
20:
1425:. Geneva: World Health Organization.
1055:from the original on 20 December 2016
1029:from the original on 12 December 2016
994:from the original on 30 December 2016
624:found commonly in food and used as a
425:
405:
76:
7:
1469:. U.S. National Library of Medicine.
1399:from the original on 14 January 2023
1360:from the original on 11 January 2023
1218:"Pyridoxine deficiency and toxicity"
941:from the original on 12 October 2013
911:from the original on 4 December 2020
838:. Pyridoxine is available both as a
165:
62:, pyridoxol pyridoxine hydrochloride
1346:. EOLSS Publications. p. 121.
644:, side effects or complications of
385:
296:
1823:2-Methylnaphthalene-1,4-diamine (K
14:
1228:from the original on 19 July 2020
901:"Pyridoxine Use During Pregnancy"
2177:
1449:
1088:10.1097/00063110-200504000-00007
510:
504:
1260:10.1007/978-3-319-20790-2_174-1
742:Pyridoxine in combination with
719:treatment and certain types of
604:Key:LXNHXLLTXMVWPM-UHFFFAOYSA-N
239:
1832:4-Amino-3-methyl-1-naphthol (K
1814:4-Amino-2-methyl-1-naphthol (K
795:. Sources in the diet include
733:numbness in the hands and feet
679:. Sources in the diet include
513:
498:
1:
760:peripheral sensory neuropathy
735:. Co-treatment with vitamin B
731:. Common side effect include
709:pyridoxine-dependent epilepsy
638:pyridoxine-dependent epilepsy
1382:Advances in Human Genetics 6
746:is used as a treatment for
2243:
1475:"Pyridoxine mass spectrum"
988:"Pyridoxine Hydrochloride"
727:used for the treatment of
648:use, and certain types of
488:Chemical and physical data
2128:
1622:25-hydroxycholecalciferol
1419:World Health Organization
1135:10.1007/s11940-014-0301-x
875:. Elsevier. p. 562.
587:
567:
251:
37:
28:
1479:Golm Metabolome Database
1252:Critical Care Toxicology
846:product. Foods, such as
1467:Drug Information Portal
1291:Assessment of vitamin B
663:. Pyridoxine is in the
1645:Dihydroergocalciferol
779:Pyridoxine is in the
705:sideroblastic anaemia
701:pyridoxine deficiency
634:sideroblastic anaemia
630:pyridoxine deficiency
2100:Dehydroascorbic acid
1604:7-Dehydrocholesterol
1458:at Wikimedia Commons
1025:. 11 February 2016.
214: / Rx-only
1994:Pyridoxal phosphate
1340:Squires VR (2011).
1318:on 17 November 2019
1224:. www.medlink.com.
867:Dryhurst G (2012).
750:in pregnant women.
713:metabolic disorders
642:metabolic disorders
238:several weeks (see
25:
2155:Never to phase III
1668:Dihydrotachysterol
1185:10.3390/nu12010157
840:generic medication
723:. Isoniazid is an
721:mushroom poisoning
715:, side effects of
650:mushroom poisoning
626:dietary supplement
579:OCc1cnc(C)c(O)c1CO
199:Pharmacy medicines
2165:
2164:
2108:
2107:
2060:Adenosylcobalamin
2035:Dihydrofolic acid
1844:
1843:
1454:Media related to
1392:978-1-4615-8264-9
1379:Harris H (2012).
1353:978-1-84826-195-2
1308:978-82-8259-260-4
1269:978-3-319-20790-2
1222:MedLink Neurology
937:. 27 April 2015.
907:. 27 April 2020.
882:978-0-323-14452-0
612:
611:
548:Interactive image
438:CompTox Dashboard
209:
196:
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16:Chemical compound
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2220:Primary alcohols
2205:Hydroxypyridines
2182:
2181:
2180:
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2070:Hydroxocobalamin
2045:Levomefolic acid
1965:Pantothenic acid
1855:
1778:Phylloquinone (K
1535:
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1311:. Archived from
1301:. Oslo, Norway.
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1254:. pp. 1–4.
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844:over the counter
748:morning sickness
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1617:Cholecalciferol
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786:
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559:Melting point
556:
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497:
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478:
475:
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471:ECHA InfoCard
467:
459:
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454:DTXSID4023541
451:
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428:
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106:
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92:
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69:
65:
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53:
50:Clinical data
48:
41:
36:
32:
27:
19:
2113:Combinations
2040:Folinic acid
1999:Pyridoxamine
1989:
1970:Dexpanthenol
1919:Sulbutiamine
1899:Benfotiamine
1894:Allithiamine
1796:Menadione (K
1755:Tocofersolan
1683:Paricalcitol
1673:Calcipotriol
1663:Alfacalcidol
1659:D analogues
1609:Previtamin D
1478:
1466:
1463:"Pyridoxine"
1432:10665/325771
1422:
1413:
1401:. Retrieved
1381:
1374:
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1342:
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1313:the original
1290:
1273:
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1221:
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814:
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757:
754:Side effects
741:
729:tuberculosis
698:
695:Medical uses
654:
614:
613:
242:for details)
231:Elimination
184:Legal status
178:Legal status
131: Exempt
86:License data
18:
2141:from market
1952:Niacinamide
1909:Octotiamine
1730:Tocotrienol
1232:14 December
1049:"Isoniazid"
1033:30 December
785:amino acids
669:amino acids
531: g·mol
477:100.000.548
407:CHEBI:16709
247:Identifiers
240:#Metabolism
55:Other names
2200:B vitamins
2194:Categories
2030:Folic acid
1990:Pyridoxine
1975:Pantethine
1932:Riboflavin
1805:Various (K
1703:Tocopherol
1678:Tacalcitol
1586:Ergosterol
1552:β-Carotene
1547:α-Carotene
1456:Pyridoxine
1322:7 December
1178:(1): 157.
1129:(7): 301.
998:8 December
854:References
817:pyridoxine
811:Metabolism
801:vegetables
744:doxylamine
725:antibiotic
711:, certain
685:vegetables
640:, certain
615:Pyridoxine
536:3D model (
524:Molar mass
427:ChEMBL1364
367:KV2JZ1BI6Z
338:ChemSpider
273:CAS Number
256:IUPAC name
105:Pyridoxine
44:Pyridoxine
23:Pyridoxine
2215:Cofactors
2151:Phase III
2139:Withdrawn
2004:Pyritinol
1884:analogues
1562:Tretinoin
1172:Nutrients
1059:13 August
905:Drugs.com
821:vitamin B
781:vitamin B
775:Mechanism
765:pregnancy
717:isoniazid
665:vitamin B
657:pregnancy
646:isoniazid
619:vitamin B
233:half-life
197: P (
142:Routes of
116:Pregnancy
78:Monograph
72:Drugs.com
58:vitamin B
2184:Medicine
1873:Thiamine
1517:Vitamins
1421:(2019).
1397:Archived
1358:Archived
1226:Archived
1204:31935866
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1096:15756083
1053:Archived
1027:Archived
992:Archived
939:Archived
909:Archived
887:Archived
318:DrugBank
154:ATC code
118:category
100:DailyMed
1851:soluble
1557:Retinol
1531:soluble
1403:30 June
1364:30 June
1195:7019938
1144:4110742
830:History
529:169.180
494:Formula
327:DB00165
293:PubChem
282:65-23-6
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2170:Portal
2134:WHO-EM
2017:Biotin
1947:Niacin
1849:Water
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803:, and
793:lipids
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687:, and
677:lipids
675:, and
572:SMILES
418:ChEMBL
387:D08454
210:
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1749:Delta
1745:Gamma
1735:Alpha
1723:Delta
1718:Gamma
1708:Alpha
1316:(PDF)
1299:(PDF)
1100:S2CID
945:6 May
935:(emc)
915:6 May
805:grain
797:fruit
689:grain
681:fruit
592:InChI
538:JSmol
398:ChEBI
1740:Beta
1713:Beta
1529:Fat
1405:2020
1387:ISBN
1366:2020
1348:ISBN
1324:2019
1303:ISBN
1264:ISBN
1234:2020
1200:PMID
1149:PMID
1092:PMID
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1000:2016
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877:ISBN
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767:and
659:and
378:KEGG
358:UNII
347:1025
307:1054
225:data
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1427:hdl
1256:doi
1190:PMC
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2012:7
2010:B
1984:6
1982:B
1960:5
1958:B
1941:3
1939:B
1927:2
1925:B
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