556:
598:
InChI=1S/C72H112O48S8/c73-33(74)1-9-121-17-25-57-41(89)49(97)65(105-25)114-58-26(18-122-10-2-34(75)76)107-67(51(99)43(58)91)116-60-28(20-124-12-4-36(79)80)109-69(53(101)45(60)93)118-62-30(22-126-14-6-38(83)84)111-71(55(103)47(62)95)120-64-32(24-128-16-8-40(87)88)112-72(56(104)48(64)96)119-63-31(23-127-15-7-39(85)86)110-70(54(102)46(63)94)117-61-29(21-125-13-5-37(81)82)108-68(52(100)44(61)92)115-59-27(19-123-11-3-35(77)78)106-66(113-57)50(98)42(59)90/h25-32,41-72,89-104H,1-24H2,(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,83,84)(H,85,86)(H,87,88)/t25-,26-,27-,28-,29-,30-,31-,32-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-/m1/s1
704:, with a lipophilic core and a hydrophilic periphery. This gamma cyclodextrin has been modified from its natural state by placing eight carboxyl thio ether groups at the sixth carbon positions. These extensions extend the cavity size allowing greater encapsulation of the rocuronium molecule. These negatively charged extensions electrostatically bind to the quaternary nitrogen of the target as well as contribute to the aqueous nature of the cyclodextrin. Sugammadex's binding encapsulation of rocuronium is one of the strongest among cyclodextrins and their guest molecules. The rocuronium molecule (a modified
734:
823:. Although sugammadex has a lower affinity for vecuronium than for rocuronium, reversal of vecuronium is still effective because fewer vecuronium molecules are present in vivo for equivalent blockade: vecuronium is approximately seven times more potent than rocuronium. Sugammadex encapsulates with a 1:1 ratio and therefore will adequately reverse vecuronium as there are fewer molecules to bind compared to rocuronium. Shallow pancuronium blockade has been successfully reversed by sugammadex in phase III clinical trials.
858:. Also when the reversal times of each agent were compared "Data indicate that sugammadex was 10.22 minutes (6.6 times) faster than neostigmine (1.96 vs 12.87 minutes) in reversing moderate induced paralysis. Sugammadex was 45.78 minutes (16.8 times) faster than neostigmine (2.9 vs 48.8 minutes) in reversing deep induced paralysis." The time saved by rapid reversal and the reduction of postoperative residual paralysis may reduce the overall hospital costs and provide significant improvements in patient safety.
483:
38:
812:). It has been demonstrated to occur only rarely with sugammadex, and only when insufficient doses were administered. The underlying mechanism is thought to be related to redistribution of relaxant after reversal. It may occur for a limited range of sugammadex doses which are sufficient for complex formation with relaxant in the central compartment, but insufficient for additional relaxant returning to central from peripheral compartments.
847:
sugammadex. The results of this review article (especially the safety results) need to be confirmed by future trials on larger patient populations". The 2017 Cochrane review concluded that sugammadex has a better safety profile than neostigmine with 40% fewer adverse events. Specifically the risks of postoperative residual paralysis, bradycardia, nausea and vomiting are reduced if sugammadex is used as a reversal agent. The
29:
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and it causes an increase in plasma potassium concentration which is dangerous in some circumstances. Rocuronium has a comparably quick onset in high dose (0.6 mg kg to 1 mg kg) and can be rapidly reversed with sugammadex (16 mg kg), so this drug combination offers an
846:
on sugammadex concluded that "sugammadex was shown to be more effective than placebo (no medication) or neostigmine in reversing muscle relaxation caused by neuromuscular blockade during surgery and is relatively safe. Serious complications occurred in less than 1% of the patients who received
800:'Recurarisation', a phenomenon of recurrence of neuromuscular block, may occur where the reversal agents wear off before a neuromuscular blocking drug is completely cleared. This is very unusual with all but the longest acting neuromuscular blocking drugs (such as
866:
Sugammadex was generally well tolerated in clinical trials in surgical patients or healthy volunteers. In pooled analyses, the tolerability profile of sugammadex was generally similar to that of placebo or neostigmine plus
2425:
3949:
1317:"Reversal of profound, high-dose rocuronium-induced neuromuscular blockade by sugammadex at two different time points: an international, multicenter, randomized, dose-finding, safety assessor-blinded, phase II trial"
853:
published an article in 2015 in which the incidence of residual neuromuscular blockade could be reduced to zero if sugammadex is used as the reversal agent and the correct dosage is selected with the use of
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Abrishami A, Ho J, Wong J, Yin L, Chung F (October 2009). Abrishami A (ed.). "Sugammadex, a selective reversal medication for preventing postoperative residual neuromuscular blockade".
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The most common side effects include cough, airway problems due to the anaesthesia wearing off, reduced blood pressure and other complications such as changes in heart rate.
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O=C(O)CCSC1O2O3(CSCCC(=O)O)O(O4(CSCCC(=O)O)O(O5(CSCCC(=O)O)O(O6(CSCCC(=O)O)O(O7(CSCCC(=O)O)O(O8(CSCCC(=O)O)O(O9(CSCCC(=O)O)O(O1(O)2O)(O)9O)(O)8O)(O)7O)(O)6O)(O)5O)(O)4O)(O)3O
1038:
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871:. Sugammadex may theoretically interfere with hormonal contraceptives due to evidence from in vitro binding studies which showed it may bind to progestogen.
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for sugammadex in 2008, but finally approved the medication for use in the United States in
December 2015. Sugammadex was approved for use in the
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Text was copied from this source which is copyright
European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
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1225:"A temporary decrease in twitch response during reversal of rocuronium-induced muscle relaxation with a small dose of sugammadex"
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781:) is not needed. Sugammadex might therefore be expected to have fewer adverse effects than the traditional reversal agents.
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When muscle relaxant with rapid onset and short duration of action is required, there has been little choice apart from
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835:. It found that sugammadex provides a rapid and dose-dependent reversal of neuromuscular blockade induced by high-dose
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113:
1441:"Effects of sugammadex on incidence of postoperative residual neuromuscular blockade: a randomized, controlled study"
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Decoopman M (2007). "Reversal of pancuronium-induced block by the selective relaxant binding agent sugammadex".
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1672:"Bridion (sugammadex) Injection - First and Only Selective Relaxant Binding Agent - Approved in European Union"
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Sugammadex has been shown to have affinity for two other aminosteroid neuromuscular blocking agents,
762:
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1392:"Efficacy and safety of sugammadex versus neostigmine in reversing neuromuscular blockade in adults"
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Pühringer FK, Rex C, Sielenkämper AW, Claudius C, Larsen PB, Prins ME, et al. (August 2008).
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2011:
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1643:"FDA approves Bridion to reverse effects of neuromuscular blocking drugs used during surgery"
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Brueckmann B, Sasaki N, Grobara P, Li MK, Woo T, de Bie J, et al. (November 2015).
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Welliver M (October 2006). "New drug sugammadex: a selective relaxant binding agent".
994:"Bridion 100 mg/ml solution for injection - Summary of Product Characteristics (SmPC)"
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708:) bound within sugammadex's lipophilic core, is rendered unavailable to bind to the
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in susceptible individuals, it has a prolonged duration of action in patients with
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Left: Schematic of a sugammadex molecule encapsulating a rocuronium molecule.
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but this drug has important contraindications; for example, it can trigger
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Sugammadex was discovered by the pharmaceutical company
Organon at the
705:
293:
1540:"Sugammadex: another milestone in clinical neuromuscular pharmacology"
1184:"Sugammadex: an opportunity to change the practice of anesthesiology?"
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4362:
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is indicated for the reversal of neuromuscular blockade induced by
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A study was carried out in Europe looking at its suitability in
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1700:
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Hristovska AM, Duch P, Allingstrup M, Afshari A (August 2017).
240:
103:
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1223:
Eleveld DJ, Kuizenga K, Proost JH, Wierda JM (March 2007).
955:
Department of Health and Aged Care. Retrieved 30 March 2023
936:
Department of Health and Aged Care. Retrieved 30 March 2023
203:
135:
2446:
3970:
1482:"Sugammadex: a review of its use in anaesthetic practice"
966:"Health Canada New Drug Authorizations: 2016 Highlights"
751:
of a sugammadex sodium molecule in the same orientation.
216:
621:
4393:
3989:
3338:
Octatropine methylbromide (anisotropine methylbromide)
5045:
895:
in 2009. Sugammadex is now owned and sold by Merck.
769:
effects are not produced and co-administration of an
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2002:
1984:
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1385:
1383:
668:Sugammadex is available as a generic medication.
3528:Scopolamine butylbromide (hyoscine butylbromide)
314:
306:
3553:Tooltip Selective serotonin reuptake inhibitors
281:
4888:Trimetaphan camsilate (trimethaphan camsylate)
1580:"U.S. FDA Issues Action Letter for Sugammadex"
1062:
1060:
1058:
1056:
5029:Acetylcholine metabolism/transport modulators
3943:
3917:Acetylcholine metabolism/transport modulators
2419:
1712:
927:SUGAMMADEX ACCORD (Accord Healthcare Pty Ltd)
8:
5024:Muscarinic acetylcholine receptor modulators
112:
19:
3912:Nicotinic acetylcholine receptor modulators
1396:The Cochrane Database of Systematic Reviews
1358:The Cochrane Database of Systematic Reviews
902:(FDA) initially rejected Schering-Plough's
260:In general: ℞ (Prescription only)
3979:
3950:
3936:
3928:
3488:3-Quinuclidinyl thiochromane-4-carboxylate
2455:
2451:Tooltip Muscarinic acetylcholine receptors
2426:
2412:
2404:
2386:
2063:
1981:
1747:
1719:
1705:
1697:
481:
354:
36:
27:
3975:Tooltip Nicotinic acetylcholine receptors
1555:
1456:
1415:
1332:
1240:
1199:
1031:"Bridion- sugammadex injection, solution"
382:
374:
4518:Candocuronium iodide (chandonium iodide)
5052:
919:
595:
575:
334:
4398:Tooltip negative allosteric modulators
3994:Tooltip positive allosteric modulators
638:, is a medication for the reversal of
472:
18:
891:in 2007; Schering-Plough merged with
459:
451:
431:
423:
85:
7:
1106:Union Register of medicinal products
176:
403:
297:
5088:Drugs developed by Merck & Co.
1557:10.1213/01.ane.0000244594.63318.fc
1242:10.1213/01.ane.0000250617.79166.7f
1201:10.1213/01.ane.0000255645.64583.e8
946:SUGAMMADEX SANDOZ (Sandoz Pty Ltd)
14:
4603:Dimethyltubocurarine (metocurine)
3150:Etybenzatropine (ethybenztropine)
2822:chlorphenamine (chlorpheniramine)
2806:Antihistamines (first-generation)
2583:Desmethylclozapine (norclozapine)
2435:Muscarinic acetylcholine receptor
1623:from the original on 10 June 2020
1128:"Dosing for Bridion (sugammadex)"
1081:from the original on 10 June 2020
1041:from the original on 10 June 2020
1004:from the original on 27 June 2021
5055:
3959:Nicotinic acetylcholine receptor
1609:"Bridion (sugammadex) Injection"
1498:10.2165/00003495-200969070-00008
723:
656:selective relaxant binding agent
506:
16:Selective relaxant binding agent
4983:Meclofenoxate (centrophenoxine)
4308:Suxethonium (succinyldicholine)
4303:Suxamethonium (succinylcholine)
3871:Meclofenoxate (centrophenoxine)
3689:northiaden (desmethyldosulepin)
1520:from the original on 2011-10-08
1138:from the original on 2019-01-12
794:pseudocholinesterase deficiency
603:Key:WHRODDIHRRDWEW-VTHZAVIASA-N
3328:N-Methyl-3-piperidyl benzilate
1445:British Journal of Anaesthesia
1366:10.1002/14651858.CD007362.pub2
850:British Journal of Anaesthesia
797:alternative to suxamethonium.
518:
512:
500:
1:
5019:Receptor/signaling modulators
4673:Hexamethonium (benzohexonium)
3907:Receptor/signaling modulators
3323:N-Ethyl-3-piperidyl benzilate
3763:cyamemazine (cyamepromazine)
1678:. 2008-07-29. Archived from
1649:. 2015-12-15. Archived from
1647:Food and Drug Administration
1615:Food and Drug Administration
1586:. 2008-08-01. Archived from
1334:10.1097/ALN.0b013e31817f5bc7
900:Food and Drug Administration
634:, sold under the brand name
4753:Methorphan (racemethorphan)
4083:Bephenium hydroxynaphthoate
3577:Tetracyclic antidepressants
3468:Profenamine (ethopropazine)
3090:Dicycloverine (dicyclomine)
887:. Organon was acquired by
700:Sugammadex is a modified γ-
5109:
4133:Dimethylphenylpiperazinium
3726:Tripitamine (tripitramine)
2950:Benzatropine (benztropine)
658:(SRBA). It is marketed by
490:Chemical and physical data
5011:
3899:
3629:Tricyclic antidepressants
3179:+beclometasone/formoterol
2756:3-Quinuclidinyl benzilate
2401:
2346:
2304:Prednisolone/promethazine
2285:Methylthioninium chloride
1480:Yang LP, Keam SJ (2009).
1408:10.1002/14651858.cd012763
1161:European Medicines Agency
1073:European Medicines Agency
611:
586:
566:
35:
26:
4993:Phosphatidylethanolamine
3881:Phosphatidylethanolamine
1544:Anesthesia and Analgesia
1229:Anesthesia and Analgesia
1188:Anesthesia and Analgesia
1182:Miller RD (March 2007).
856:neuromuscular monitoring
833:rapid sequence induction
4773:Morphanol (racemorphan)
4713:Laudexium (laudolissin)
4123:Desformylflustrabromine
3105:Diphemanil metilsulfate
2960:Benzilylcholine mustard
2907:Atypical antipsychotics
1538:Naguib M (March 2007).
3751:Typical antipsychotics
3523:Scopolamine (hyoscine)
3198:Hexahydrosiladifenidol
3175:Glycopyrronium bromide
2392:Acetylcholine receptor
2297:Potassium permanganate
1953:neuromuscular blockade
881:Newhouse Research Site
790:malignant hyperthermia
775:glycopyrronium bromide
737:
714:neuromuscular junction
710:acetylcholine receptor
640:neuromuscular blockade
4978:Glycerophosphocholine
3866:Glycerophosphocholine
3669:dosulepin (dothiepin)
3473:Propantheline bromide
3348:Otenzepad (AF-DX 116)
2902:Atropine methonitrate
2099:4-Dimethylaminophenol
1077:. 17 September 2018.
736:
4973:Dimethylethanolamine
4838:Rapacuronium bromide
4818:Pipecuronium bromide
4658:Gantacurium chloride
4618:Dizocilpine (MK-801)
4203:MEM-63,908 (RG-3487)
4153:Ethoxysebacylcholine
3861:Dimethylethanolamine
3781:Umeclidinium bromide
3661:desmethyldesipramine
3378:Oxyphenonium bromide
2588:Ethoxysebacylcholine
2187:Paracetamol toxicity
2031:direct Xa inhibitors
1752:Alcohol intoxication
1132:www.merckconnect.com
1037:. 14 December 2018.
904:New Drug Application
763:acetylcholinesterase
53:soo GAM ma dex
4988:Phosphatidylcholine
4873:Threohydrobupropion
4858:Stercuronium iodide
4793:Pancuronium bromide
3876:Phosphatidylcholine
3538:Sofpironium bromide
3423:Pipenzolate bromide
3233:Ipratropium bromide
3035:Cimetropium bromide
1619:. 4 February 2016.
1300:Eur J Anaesthesiol.
1157:"Sugammadex Adroiq"
1102:"Sugammadex Adroiq"
761:, does not inhibit
757:Sugammadex, unlike
749:Space-filling model
652:general anaesthesia
236:(Prescription only)
212:(Prescription only)
23:
4908:Vecuronium bromide
4848:Rocuronium bromide
4758:Methyllycaconitine
4683:Hydroxynorketamine
4578:Dextropropoxyphene
4563:Dehydronorketamine
4553:Dacuronium bromide
3609:Tiotropium bromide
3604:Timepidium bromide
3363:Oxitropium bromide
3318:Muscarinic toxin 7
3193:Hexahydrodifenidol
3140:Emepronium bromide
2791:Ambutonium bromide
2766:Aclidinium bromide
2373:Never to phase III
2170:Primary alcohols:
2128:Sodium thiosulfate
2012:Digoxin immune fab
1458:10.1093/bja/aev104
951:2022-10-12 at the
932:2022-10-12 at the
738:
654:. It is the first
5043:
5042:
5037:
5036:
4998:Phosphorylcholine
4936:
4921:
4920:
4718:Levacetylmethadol
4598:Dihydrochandonium
4478:sodium thiopental
4148:Ethanol (alcohol)
3925:
3924:
3886:Phosphorylcholine
3824:
3809:
3808:
3746:Trospium chloride
3641:amitriptylinoxide
3614:Tiquizium bromide
3458:Prifinium bromide
3353:Otilonium bromide
3308:Methylscopolamine
3303:Methylhomatropine
3160:Fentonium bromide
3040:Clidinium bromide
2383:
2382:
2312:
2311:
2146:Calcium gluconate
2138:Hydrofluoric acid
2091:Cyanide poisoning
2068:Arsenic poisoning
2055:
2054:
1969:
1968:
1674:(Press release).
1645:(Press release).
1582:(Press release).
1000:. 18 March 2021.
742:
741:
629:
628:
557:Interactive image
256:
244:
231:
219:
207:
139:
106:
5100:
5083:Oligosaccharides
5060:
5059:
5058:
5051:
4930:
4868:Thiocolchicoside
4678:Hydroxybupropion
4573:Dextromethorphan
4445:Allopregnanolone
4399:
4395:
4298:Suberyldicholine
4008:6-Chloronicotine
3995:
3991:
3980:
3976:
3972:
3952:
3945:
3938:
3929:
3818:
3599:Tiemonium iodide
3554:
3550:
3418:Phenyltoloxamine
3373:Oxyphencyclimine
2874:phenyltoloxamine
2678:Suberyldicholine
2456:
2452:
2448:
2428:
2421:
2414:
2405:
2387:
2278:Potassium iodide
2104:Hydroxocobalamin
2064:
2004:Digoxin toxicity
1982:
1748:
1721:
1714:
1707:
1698:
1691:
1690:
1688:
1687:
1668:
1662:
1661:
1659:
1658:
1639:
1633:
1632:
1630:
1628:
1605:
1599:
1598:
1596:
1595:
1576:
1570:
1569:
1559:
1535:
1529:
1528:
1526:
1525:
1477:
1471:
1470:
1460:
1436:
1430:
1429:
1419:
1387:
1378:
1377:
1353:
1347:
1346:
1336:
1312:
1306:
1296:
1290:
1289:
1269:
1263:
1262:
1244:
1220:
1214:
1213:
1203:
1179:
1173:
1172:
1170:
1168:
1153:
1147:
1146:
1144:
1143:
1124:
1118:
1117:
1115:
1113:
1098:
1092:
1090:
1088:
1086:
1064:
1051:
1050:
1048:
1046:
1027:
1014:
1013:
1011:
1009:
990:
984:
983:
981:
979:
962:
956:
943:
937:
924:
727:
720:
696:Pharmacodynamics
625:
624:
617:
559:
539:
537:
520:
514:
508:
502:
485:
474:
463:
455:
435:
427:
407:
386:
378:
358:
338:
318:
310:
300:
299:
285:
254:
251:
242:
239:
229:
226:
218:
215:
205:
202:
180:
137:
134:
116:
105:
102:
89:
40:
31:
24:
22:
5108:
5107:
5103:
5102:
5101:
5099:
5098:
5097:
5068:
5067:
5066:
5056:
5054:
5046:
5044:
5039:
5038:
5033:
5007:
4929:
4917:
4523:Chlorisondamine
4397:
4390:
4382:
3993:
3986:
3974:
3964:
3956:
3926:
3921:
3895:
3817:
3805:
3759:chlorprothixene
3716:Trihexyphenidyl
3552:
3533:Silahexacyclium
3413:Phenglutarimide
3075:Desfesoterodine
3055:Cyclobenzaprine
2846:diphenhydramine
2810:brompheniramine
2742:
2693:Thiopilocarpine
2450:
2440:
2432:
2397:
2384:
2379:
2378:
2363:Clinical trials
2342:
2336:Syrup of ipecac
2308:
2291:oxidizing agent
2259:
2211:
2190:(Acetaminophen)
2189:
2181:
2162:
2161:Ethylene glycol
2159:
2150:
2132:
2085:
2051:
2016:
1998:
1976:
1965:
1951:
1945:
1908:Opioid overdose
1902:
1854:
1853:Organophosphate
1851:
1842:
1819:
1801:
1794:
1776:
1769:
1742:
1735:
1725:
1695:
1694:
1685:
1683:
1676:Schering-Plough
1670:
1669:
1665:
1656:
1654:
1641:
1640:
1636:
1626:
1624:
1607:
1606:
1602:
1593:
1591:
1584:Schering-Plough
1578:
1577:
1573:
1537:
1536:
1532:
1523:
1521:
1479:
1478:
1474:
1438:
1437:
1433:
1402:(8): CD012763.
1389:
1388:
1381:
1360:(4): CD007362.
1355:
1354:
1350:
1314:
1313:
1309:
1297:
1293:
1271:
1270:
1266:
1222:
1221:
1217:
1181:
1180:
1176:
1166:
1164:
1155:
1154:
1150:
1141:
1139:
1126:
1125:
1121:
1111:
1109:
1100:
1099:
1095:
1084:
1082:
1066:
1065:
1054:
1044:
1042:
1029:
1028:
1017:
1007:
1005:
992:
991:
987:
977:
975:
974:. 14 March 2017
964:
963:
959:
953:Wayback Machine
944:
940:
934:Wayback Machine
925:
921:
916:
889:Schering-Plough
877:
864:
844:Cochrane review
829:
786:succinylcholine
756:
754:
753:
752:
746:
698:
693:
674:
620:
618:
615:(what is this?)
612:
607:
604:
599:
594:
593:
582:
579:
574:
573:
562:
535:
533:
523:
517:
511:
505:
466:
438:
410:
389:
361:
341:
321:
296:
288:
263:
184:
152:
145:
126:
119:
17:
12:
11:
5:
5106:
5104:
5096:
5095:
5090:
5085:
5080:
5070:
5069:
5065:
5064:
5041:
5040:
5035:
5034:
5032:
5031:
5026:
5021:
5016:
5012:
5009:
5008:
5006:
5005:
5000:
4995:
4990:
4985:
4980:
4975:
4970:
4965:
4960:
4950:
4945:
4939:
4937:
4923:
4922:
4919:
4918:
4916:
4915:
4910:
4905:
4900:
4895:
4890:
4885:
4880:
4875:
4870:
4865:
4860:
4855:
4850:
4845:
4840:
4835:
4830:
4825:
4820:
4815:
4810:
4805:
4800:
4795:
4790:
4785:
4780:
4775:
4770:
4765:
4760:
4755:
4750:
4745:
4740:
4735:
4730:
4725:
4720:
4715:
4710:
4705:
4703:Kynurenic acid
4700:
4695:
4690:
4685:
4680:
4675:
4670:
4665:
4660:
4655:
4650:
4645:
4640:
4635:
4630:
4625:
4620:
4615:
4610:
4605:
4600:
4595:
4590:
4585:
4580:
4575:
4570:
4565:
4560:
4555:
4550:
4545:
4540:
4535:
4530:
4525:
4520:
4515:
4510:
4505:
4500:
4497:κ-bungarotoxin
4493:α-bungarotoxin
4486:
4481:
4467:
4462:
4457:
4452:
4447:
4442:
4437:
4432:
4431:, many others)
4421:α-bungarotoxin
4414:
4409:
4403:
4401:
4384:
4383:
4381:
4380:
4375:
4370:
4365:
4360:
4355:
4353:Tribendimidine
4350:
4345:
4340:
4335:
4330:
4325:
4320:
4315:
4310:
4305:
4300:
4295:
4290:
4285:
4280:
4278:Sebacylcholine
4275:
4270:
4265:
4260:
4255:
4250:
4245:
4240:
4235:
4230:
4225:
4220:
4210:
4205:
4200:
4195:
4190:
4185:
4180:
4175:
4170:
4165:
4160:
4155:
4150:
4145:
4140:
4135:
4130:
4125:
4120:
4115:
4110:
4105:
4100:
4095:
4093:Butyrylcholine
4090:
4085:
4080:
4075:
4070:
4065:
4060:
4055:
4050:
4045:
4040:
4035:
4030:
4025:
4020:
4015:
4010:
4005:
3999:
3997:
3977:
3966:
3965:
3957:
3955:
3954:
3947:
3940:
3932:
3923:
3922:
3920:
3919:
3914:
3909:
3904:
3900:
3897:
3896:
3894:
3893:
3888:
3883:
3878:
3873:
3868:
3863:
3858:
3853:
3848:
3838:
3833:
3827:
3825:
3811:
3810:
3807:
3806:
3804:
3803:
3798:
3793:
3788:
3778:
3755:chlorpromazine
3748:
3743:
3738:
3733:
3728:
3723:
3718:
3713:
3708:
3626:
3621:
3616:
3611:
3606:
3601:
3596:
3574:
3569:
3564:
3545:
3540:
3535:
3530:
3525:
3520:
3515:
3510:
3505:
3500:
3495:
3490:
3485:
3480:
3475:
3470:
3465:
3460:
3455:
3450:
3445:
3440:
3435:
3430:
3425:
3420:
3415:
3410:
3405:
3400:
3395:
3390:
3385:
3380:
3375:
3370:
3365:
3360:
3358:Oxapium iodide
3355:
3350:
3345:
3340:
3335:
3330:
3325:
3320:
3315:
3310:
3305:
3300:
3298:Methylatropine
3295:
3290:
3285:
3280:
3275:
3270:
3265:
3260:
3255:
3250:
3245:
3240:
3230:
3225:
3220:
3215:
3210:
3205:
3200:
3195:
3190:
3172:
3167:
3162:
3157:
3152:
3147:
3142:
3137:
3132:
3127:
3122:
3117:
3112:
3107:
3102:
3097:
3092:
3087:
3082:
3077:
3072:
3067:
3062:
3060:Cyclopentolate
3057:
3052:
3047:
3042:
3037:
3032:
3027:
3022:
3017:
3012:
3007:
3002:
2997:
2992:
2987:
2982:
2977:
2972:
2967:
2962:
2957:
2952:
2947:
2942:
2904:
2899:
2894:
2889:
2838:dimenhydrinate
2834:cyproheptadine
2803:
2798:
2793:
2788:
2783:
2778:
2773:
2763:
2758:
2752:
2750:
2744:
2743:
2741:
2740:
2735:
2730:
2725:
2720:
2715:
2710:
2705:
2700:
2695:
2690:
2685:
2680:
2675:
2673:Sebacylcholine
2670:
2665:
2660:
2655:
2650:
2645:
2640:
2635:
2630:
2625:
2620:
2615:
2610:
2605:
2600:
2595:
2590:
2585:
2580:
2575:
2570:
2565:
2560:
2555:
2550:
2545:
2540:
2535:
2530:
2528:Butyrylcholine
2525:
2520:
2515:
2510:
2505:
2500:
2495:
2490:
2485:
2480:
2475:
2470:
2464:
2462:
2453:
2442:
2441:
2433:
2431:
2430:
2423:
2416:
2408:
2402:
2399:
2398:
2390:
2381:
2380:
2377:
2376:
2375:
2374:
2371:
2360:
2354:
2348:
2347:
2344:
2343:
2341:
2340:
2339:
2338:
2328:
2326:Copper sulfate
2322:
2320:
2314:
2313:
2310:
2309:
2307:
2306:
2301:
2300:
2299:
2287:
2282:
2281:
2280:
2267:
2265:
2261:
2260:
2258:
2253:
2248:
2243:
2241:
2240:
2239:
2233:
2228:
2213:
2212:
2210:
2209:
2204:
2199:
2197:Acetylcysteine
2193:
2191:
2183:
2182:
2180:
2179:
2174:
2167:
2165:
2152:
2151:
2149:
2148:
2142:
2140:
2134:
2133:
2131:
2130:
2125:
2124:
2123:
2121:Sodium nitrite
2118:
2106:
2101:
2095:
2093:
2087:
2086:
2084:
2083:
2078:
2072:
2070:
2061:
2057:
2056:
2053:
2052:
2050:
2049:
2038:
2035:Andexanet alfa
2026:
2024:
2022:Anticoagulants
2018:
2017:
2015:
2014:
2008:
2006:
2000:
1999:
1997:
1996:
1990:
1988:
1979:
1971:
1970:
1967:
1966:
1964:
1963:
1957:
1955:
1947:
1946:
1944:
1943:
1938:
1933:
1928:
1923:
1918:
1912:
1910:
1904:
1903:
1901:
1900:
1898:Cholinesterase
1892:
1891:
1890:
1885:
1875:
1870:
1865:
1859:
1857:
1844:
1843:
1841:
1840:
1835:
1829:
1827:
1821:
1820:
1818:
1817:
1812:
1806:
1804:
1800:Benzodiazepine
1796:
1795:
1793:
1792:
1787:
1781:
1779:
1771:
1770:
1768:
1767:
1762:
1756:
1754:
1745:
1737:
1736:
1726:
1724:
1723:
1716:
1709:
1701:
1693:
1692:
1663:
1634:
1600:
1571:
1550:(3): 575–581.
1530:
1492:(7): 919–942.
1472:
1451:(5): 743–751.
1431:
1379:
1348:
1327:(2): 188–197.
1321:Anesthesiology
1307:
1291:
1280:(5): 357–363.
1264:
1235:(3): 582–584.
1215:
1194:(3): 477–478.
1174:
1163:. 16 June 2023
1148:
1119:
1093:
1068:"Bridion EPAR"
1052:
1015:
985:
957:
938:
918:
917:
915:
912:
910:in July 2008.
908:European Union
876:
873:
869:glycopyrrolate
863:
860:
828:
825:
771:antimuscarinic
744:
743:
740:
739:
730:
728:
718:
697:
694:
692:
689:
673:
670:
627:
626:
609:
608:
606:
605:
602:
600:
597:
589:
588:
587:
584:
583:
581:
580:
577:
569:
568:
567:
564:
563:
561:
560:
552:
550:
542:
541:
531:
525:
524:
521:
515:
509:
503:
498:
492:
491:
487:
486:
476:
468:
467:
465:
464:
458:as salt:
456:
448:
446:
440:
439:
437:
436:
430:as salt:
428:
420:
418:
412:
411:
409:
408:
402:as salt:
399:
397:
391:
390:
388:
387:
381:as salt:
379:
371:
369:
363:
362:
360:
359:
351:
349:
343:
342:
340:
339:
331:
329:
323:
322:
320:
319:
313:as salt:
311:
303:
301:
290:
289:
287:
286:
278:
276:
270:
269:
265:
264:
262:
261:
258:
249:
237:
224:
213:
199:
197:
191:
190:
186:
185:
183:
182:
169:
167:
161:
160:
155:
153:administration
147:
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144:
143:
141:
131:
129:
121:
120:
118:
117:
99:
97:
91:
90:
83:
73:
72:
69:
65:
64:
61:
55:
54:
51:
47:
46:
42:
41:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
5105:
5094:
5091:
5089:
5086:
5084:
5081:
5079:
5076:
5075:
5073:
5063:
5053:
5049:
5030:
5027:
5025:
5022:
5020:
5017:
5014:
5013:
5010:
5004:
5001:
4999:
4996:
4994:
4991:
4989:
4986:
4984:
4981:
4979:
4976:
4974:
4971:
4969:
4966:
4964:
4961:
4958:
4954:
4951:
4949:
4946:
4944:
4941:
4940:
4938:
4934:
4928:
4924:
4914:
4911:
4909:
4906:
4904:
4901:
4899:
4896:
4894:
4891:
4889:
4886:
4884:
4881:
4879:
4876:
4874:
4871:
4869:
4866:
4864:
4861:
4859:
4856:
4854:
4851:
4849:
4846:
4844:
4841:
4839:
4836:
4834:
4831:
4829:
4826:
4824:
4821:
4819:
4816:
4814:
4813:Phencyclidine
4811:
4809:
4806:
4804:
4801:
4799:
4796:
4794:
4791:
4789:
4786:
4784:
4783:Nitrous oxide
4781:
4779:
4776:
4774:
4771:
4769:
4766:
4764:
4761:
4759:
4756:
4754:
4751:
4749:
4746:
4744:
4741:
4739:
4736:
4734:
4731:
4729:
4726:
4724:
4723:Levomethadone
4721:
4719:
4716:
4714:
4711:
4709:
4706:
4704:
4701:
4699:
4696:
4694:
4691:
4689:
4686:
4684:
4681:
4679:
4676:
4674:
4671:
4669:
4668:Hexafluronium
4666:
4664:
4661:
4659:
4656:
4654:
4651:
4649:
4646:
4644:
4641:
4639:
4636:
4634:
4631:
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4616:
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4611:
4609:
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4586:
4584:
4581:
4579:
4576:
4574:
4571:
4569:
4566:
4564:
4561:
4559:
4558:Decamethonium
4556:
4554:
4551:
4549:
4546:
4544:
4541:
4539:
4536:
4534:
4531:
4529:
4528:Cisatracurium
4526:
4524:
4521:
4519:
4516:
4514:
4511:
4509:
4506:
4504:
4501:
4498:
4494:
4490:
4489:Bungarotoxins
4487:
4485:
4482:
4479:
4475:
4474:pentobarbital
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4453:
4451:
4448:
4446:
4443:
4441:
4438:
4436:
4433:
4430:
4426:
4422:
4418:
4417:α-Neurotoxins
4415:
4413:
4410:
4408:
4405:
4404:
4402:
4396:
4389:
4385:
4379:
4376:
4374:
4371:
4369:
4366:
4364:
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4344:
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4339:
4336:
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4326:
4324:
4321:
4319:
4316:
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4311:
4309:
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4299:
4296:
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4264:
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4146:
4144:
4141:
4139:
4136:
4134:
4131:
4129:
4126:
4124:
4121:
4119:
4118:Decamethonium
4116:
4114:
4111:
4109:
4106:
4104:
4101:
4099:
4096:
4094:
4091:
4089:
4086:
4084:
4081:
4079:
4076:
4074:
4071:
4069:
4066:
4064:
4061:
4059:
4056:
4054:
4053:Acetylcholine
4051:
4049:
4046:
4044:
4041:
4039:
4036:
4034:
4031:
4029:
4026:
4024:
4021:
4019:
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4009:
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4000:
3998:
3992:
3985:
3981:
3978:
3973:
3967:
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3960:
3953:
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3837:
3834:
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3826:
3822:
3816:
3812:
3802:
3799:
3797:
3794:
3792:
3789:
3786:
3782:
3779:
3776:
3772:
3768:
3764:
3760:
3756:
3752:
3749:
3747:
3744:
3742:
3739:
3737:
3734:
3732:
3729:
3727:
3724:
3722:
3719:
3717:
3714:
3712:
3711:Tridihexethyl
3709:
3706:
3702:
3698:
3697:protriptyline
3694:
3693:nortriptyline
3690:
3686:
3685:nitroxazepine
3682:
3678:
3674:
3670:
3666:
3662:
3658:
3654:
3650:
3646:
3642:
3638:
3637:+perphenazine
3634:
3633:amitriptyline
3630:
3627:
3625:
3622:
3620:
3617:
3615:
3612:
3610:
3607:
3605:
3602:
3600:
3597:
3594:
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3586:
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3578:
3575:
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3562:
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3509:
3506:
3504:
3501:
3499:
3496:
3494:
3491:
3489:
3486:
3484:
3481:
3479:
3476:
3474:
3471:
3469:
3466:
3464:
3461:
3459:
3456:
3454:
3451:
3449:
3446:
3444:
3441:
3439:
3436:
3434:
3431:
3429:
3426:
3424:
3421:
3419:
3416:
3414:
3411:
3409:
3406:
3404:
3401:
3399:
3396:
3394:
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3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3366:
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3361:
3359:
3356:
3354:
3351:
3349:
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3336:
3334:
3331:
3329:
3326:
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3321:
3319:
3316:
3314:
3311:
3309:
3306:
3304:
3301:
3299:
3296:
3294:
3293:Methoctramine
3291:
3289:
3288:Methantheline
3286:
3284:
3281:
3279:
3276:
3274:
3271:
3269:
3266:
3264:
3263:Mamba toxin 7
3261:
3259:
3258:Mamba toxin 3
3256:
3254:
3251:
3249:
3246:
3244:
3241:
3238:
3234:
3231:
3229:
3226:
3224:
3221:
3219:
3216:
3214:
3211:
3209:
3206:
3204:
3201:
3199:
3196:
3194:
3191:
3188:
3184:
3180:
3176:
3173:
3171:
3168:
3166:
3163:
3161:
3158:
3156:
3155:Fenpiverinium
3153:
3151:
3148:
3146:
3143:
3141:
3138:
3136:
3133:
3131:
3128:
3126:
3123:
3121:
3118:
3116:
3113:
3111:
3108:
3106:
3103:
3101:
3098:
3096:
3093:
3091:
3088:
3086:
3083:
3081:
3078:
3076:
3073:
3071:
3068:
3066:
3063:
3061:
3058:
3056:
3053:
3051:
3048:
3046:
3043:
3041:
3038:
3036:
3033:
3031:
3028:
3026:
3023:
3021:
3018:
3016:
3013:
3011:
3008:
3006:
3003:
3001:
2998:
2996:
2993:
2991:
2988:
2986:
2983:
2981:
2978:
2976:
2973:
2971:
2968:
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2900:
2898:
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2879:
2875:
2871:
2867:
2863:
2859:
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2831:
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2823:
2819:
2815:
2811:
2807:
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2802:
2799:
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2782:
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2609:
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2601:
2599:
2596:
2594:
2591:
2589:
2586:
2584:
2581:
2579:
2576:
2574:
2573:cis-Dioxolane
2571:
2569:
2566:
2564:
2561:
2559:
2556:
2554:
2551:
2549:
2546:
2544:
2541:
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2536:
2534:
2531:
2529:
2526:
2524:
2521:
2519:
2516:
2514:
2511:
2509:
2506:
2504:
2501:
2499:
2496:
2494:
2491:
2489:
2488:Acetylcholine
2486:
2484:
2481:
2479:
2476:
2474:
2471:
2469:
2466:
2465:
2463:
2461:
2457:
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2400:
2396:
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2319:
2315:
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2298:
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2288:
2286:
2283:
2279:
2276:
2275:
2274:
2273:
2269:
2268:
2266:
2262:
2257:
2256:Prussian blue
2254:
2252:
2249:
2247:
2244:
2242:
2237:
2234:
2232:
2229:
2227:
2224:
2223:
2222:
2218:
2214:
2208:
2205:
2203:
2200:
2198:
2195:
2194:
2192:
2188:
2184:
2178:
2175:
2173:
2169:
2168:
2166:
2164:
2157:
2153:
2147:
2144:
2143:
2141:
2139:
2135:
2129:
2126:
2122:
2119:
2117:
2114:
2113:
2112:
2111:
2107:
2105:
2102:
2100:
2097:
2096:
2094:
2092:
2088:
2082:
2079:
2077:
2074:
2073:
2071:
2069:
2065:
2062:
2058:
2047:
2043:
2039:
2036:
2032:
2028:
2027:
2025:
2023:
2019:
2013:
2010:
2009:
2007:
2005:
2001:
1995:
1992:
1991:
1989:
1987:
1983:
1980:
1978:
1972:
1962:
1959:
1958:
1956:
1954:
1948:
1942:
1939:
1937:
1934:
1932:
1929:
1927:
1924:
1922:
1919:
1917:
1916:Diprenorphine
1914:
1913:
1911:
1909:
1905:
1899:
1896:
1893:
1889:
1886:
1884:
1881:
1880:
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1869:
1866:
1864:
1861:
1860:
1858:
1856:
1849:
1845:
1839:
1836:
1834:
1833:Physostigmine
1831:
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1828:
1826:
1822:
1816:
1813:
1811:
1808:
1807:
1805:
1803:
1797:
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1744:
1738:
1733:
1729:
1722:
1717:
1715:
1710:
1708:
1703:
1702:
1699:
1682:on 2008-09-24
1681:
1677:
1673:
1667:
1664:
1653:on 2015-12-15
1652:
1648:
1644:
1638:
1635:
1622:
1618:
1616:
1610:
1604:
1601:
1590:on 2008-08-10
1589:
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1129:
1123:
1120:
1108:. 30 May 2023
1107:
1103:
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989:
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971:Health Canada
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695:
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551:
548:
543:
532:
530:
526:
499:
497:
493:
488:
484:
480:
477:
475:
473:ECHA InfoCard
469:
462:
461:ChEMBL2107374
457:
454:
453:ChEMBL2111107
450:
449:
447:
445:
441:
434:
429:
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385:
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309:
305:
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295:
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280:
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259:
257: Rx-only
250:
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115:
110:
101:
100:
98:
96:
92:
88:
84:
82:
78:
74:
70:
66:
62:
60:
56:
52:
50:Pronunciation
48:
45:Clinical data
43:
39:
34:
30:
25:
4898:Tubocurarine
4828:Promegestone
4823:Progesterone
4738:Mecamylamine
4548:Cyclopropane
4538:Coronaridine
4470:Barbiturates
4455:Anatruxonium
4425:α-cobratoxin
4268:Sazetidine A
4188:JNJ-39393406
4178:Ispronicline
3775:thioridazine
3771:mesoridazine
3705:trimipramine
3701:quinupramine
3653:clomipramine
3645:butriptyline
3463:Procyclidine
3428:Piperidolate
3343:Orphenadrine
3243:Isopropamide
3228:Imidafenacin
3187:+neostigmine
3183:+indacaterol
3165:Fesoterodine
3095:Dihexyverine
3045:Cloperastine
2915:fluperlapine
2886:triprolidine
2882:propiomazine
2878:promethazine
2866:phenindamine
2683:Talsaclidine
2643:Oxotremorine
2618:Methacholine
2608:LY-2,033,298
2289:
2270:
2217:Toxic metals
2116:Amyl nitrite
2108:
1986:Beta blocker
1960:
1894:
1825:GHB overdose
1684:. Retrieved
1680:the original
1666:
1655:. Retrieved
1651:the original
1637:
1625:. Retrieved
1612:
1603:
1592:. Retrieved
1588:the original
1574:
1547:
1543:
1533:
1522:. Retrieved
1489:
1485:
1475:
1448:
1444:
1434:
1399:
1395:
1357:
1351:
1324:
1320:
1310:
1303:
1302:24(Suppl 39)
1299:
1294:
1277:
1274:AANA Journal
1273:
1267:
1232:
1228:
1218:
1191:
1187:
1177:
1165:. Retrieved
1160:
1151:
1140:. Retrieved
1131:
1122:
1110:. Retrieved
1105:
1096:
1083:. Retrieved
1071:
1043:. Retrieved
1034:
1006:. Retrieved
997:
988:
976:. Retrieved
969:
960:
941:
922:
897:
878:
865:
862:Tolerability
848:
841:
830:
814:
810:tubocurarine
799:
783:
755:
702:cyclodextrin
699:
691:Pharmacology
676:
675:
672:Medical uses
667:
664:
635:
631:
630:
619:
613:
195:Legal status
189:Legal status
95:License data
5003:Pirisudanol
4968:Cyprodenate
4948:Adafenoxate
4863:Surugatoxin
4853:Sevoflurane
4808:Pentolinium
4788:Norketamine
4708:Laudanosine
4638:Erythravine
4628:Encenicline
4613:Dipyrandium
4583:Dextrorphan
4429:α-conotoxin
4388:Antagonists
4373:WAY-317,538
4368:Varenicline
4358:Tropisetron
4348:Tebanicline
4293:SSR-180,711
4258:Rivanicline
4248:Pozanicline
4243:PNU-282,987
4238:PNU-120,596
4233:PHA-709,829
4228:PHA-543,613
4168:Galantamine
4143:Epiboxidine
4138:Epibatidine
4058:Altinicline
3891:Pirisudanol
3856:Cyprodenate
3836:Adafenoxate
3801:Zamifenacin
3785:+vilanterol
3741:Tropicamide
3736:Tropatepine
3721:Trimebutine
3681:lofepramine
3657:desipramine
3624:Tolterodine
3593:mirtazapine
3585:maprotiline
3567:Telenzepine
3543:Solifenacin
3518:SCH-217,443
3493:Revefenacin
3478:Propiverine
3438:Piroheptine
3433:Pirenzepine
3398:Penthienate
3283:Mepenzolate
3278:Meladrazine
3253:Hyoscyamine
3237:+salbutamol
3223:Homatropine
3208:Hexocyclium
3065:Darifenacin
3025:CAR-302,668
3020:CAR-302,537
3015:CAR-302,368
3010:CAR-302,282
3005:CAR-302,196
3000:CAR-301,060
2995:CAR-226,086
2965:Benzydamine
2945:Benactyzine
2923:+fluoxetine
2870:pheniramine
2858:mequitazine
2842:dimetindene
2826:cinnarizine
2796:Anisodamine
2770:+formoterol
2748:Antagonists
2728:WAY-132,983
2698:Vedaclidine
2668:SDZ 210-086
2663:Sabcomeline
2653:Pilocarpine
2523:Bethanechol
2359:from market
2331:Ipecacuanha
2246:Dimercaprol
2202:Glutathione
2076:Dimercaprol
1975:Circulatory
1950:Reversal of
1888:Pralidoxime
1848:Nerve agent
1810:Cyprodenate
1775:Barbiturate
821:pancuronium
806:pancuronium
767:cholinergic
759:neostigmine
642:induced by
540: g·mol
479:100.121.931
433:CHEBI:90952
425:CHEBI:90953
283:343306-71-8
268:Identifiers
158:Intravenous
68:Other names
59:Trade names
5093:Thioethers
5078:Anesthesia
5072:Categories
4963:Citicoline
4943:Acetyl-coA
4927:Precursors
4903:Vanoxerine
4893:Tropeinium
4878:Toxiferine
4843:Reboxetine
4833:Radafaxine
4778:Neramexane
4768:Mivacurium
4763:Metocurine
4728:Malouetine
4693:Isoflurane
4648:Fazadinium
4643:Esketamine
4623:Doxacurium
4608:Dioscorine
4568:Desflurane
4533:Coclaurine
4465:Atracurium
4450:Amantadine
4440:Alcuronium
4193:Levamisole
4183:Ivermectin
4128:Dianicline
4088:Butinoline
4073:Anatoxin-a
3962:modulators
3851:Citicoline
3831:Acetyl-coA
3815:Precursors
3796:Xanomeline
3677:imipramine
3665:dibenzepin
3572:Terodiline
3561:paroxetine
3557:femoxetine
3513:SCH-72,788
3508:SCH-57,790
3498:Rociverine
3393:PD-0298029
3388:PD-102,807
3368:Oxybutynin
3273:Mebeverine
3218:HL-031,120
3203:Hexbutinol
3145:Etanautine
3100:Difemerine
3080:Dexetimide
3030:Caramiphen
2985:Bornaprine
2935:tenilapine
2931:quetiapine
2919:olanzapine
2850:doxylamine
2830:clemastine
2818:captodiame
2776:Abediterol
2733:Xanomeline
2723:VU-0238429
2718:VU-0152100
2713:VU-0152099
2708:VU-0090157
2703:VU-0029767
2688:Tazomeline
2648:PD-151,832
2638:Ocvimeline
2623:Milameline
2598:LY-593,039
2563:Cevimeline
2508:Alvameline
2483:Aceclidine
2478:AC-260,584
2468:77-LH-28-1
2438:modulators
2395:modulators
2272:iodine-131
2207:Methionine
2177:Fomepizole
1961:Sugammadex
1941:Naltrexone
1931:Nalorphine
1815:Flumazenil
1760:Metadoxine
1686:2008-08-02
1657:2015-12-15
1594:2008-08-02
1524:2010-03-29
1142:2019-01-11
914:References
837:rocuronium
817:vecuronium
685:vecuronium
681:rocuronium
677:Sugammadex
648:vecuronium
644:rocuronium
632:Sugammadex
545:3D model (
529:Molar mass
384:ERJ6X2MXV7
376:361LPM2T56
347:ChemSpider
274:CAS Number
114:Sugammadex
21:Sugammadex
4803:Pentamine
4798:Pempidine
4748:Methadone
4743:Memantine
4663:Halothane
4653:Gallamine
4633:Enflurane
4588:Diadonium
4503:Bupropion
4288:SIB-1553A
4283:SIB-1508Y
4273:SB-206553
4098:Carbachol
4078:AR-R17779
4068:Anatabine
4063:Anabasine
4028:A-867,744
4023:A-582,941
4018:A-366,833
3731:Tropacine
3649:cidoxepin
3619:Tofenacin
3589:mianserin
3581:amoxapine
3503:RU-47,213
3483:Quinidine
3443:Pizotifen
3403:Pethidine
3268:Mazaticol
3248:J-104,129
3213:Himbacine
3170:Flavoxate
3115:Drofenine
2990:Camylofin
2980:Biperiden
2955:Benzilone
2911:clozapine
2892:AQ-RA 741
2862:perlapine
2854:meclizine
2814:buclizine
2801:Anisodine
2786:AF-DX 384
2781:AF-DX 250
2628:Muscarine
2603:L-689,660
2593:Itameline
2578:Clozapine
2533:Carbachol
2518:Arecoline
2369:Phase III
2357:Withdrawn
2163:poisoning
2046:Protamine
1926:Nalmefene
1895:see also:
1883:Obidoxime
1868:Biperiden
1855:poisoning
1838:SCH-50911
1790:Ethamivan
1785:Bemegride
1728:Antidotes
1514:195685307
1304::110-111.
802:gallamine
151:Routes of
125:Pregnancy
87:Monograph
81:Drugs.com
71:ORG-25969
5062:Medicine
5015:See also
4957:lecithin
4933:prodrugs
4883:Tramadol
4733:ME-18-MC
4698:Ketamine
4688:Ibogaine
4508:BW284C51
4263:RJR-2429
4253:Pyrantel
4213:Nicotine
4208:Morantel
4198:Lobeline
4163:EVP-6124
4158:EVP-4473
4113:Cytisine
4108:Cotinine
4013:A-84,543
3984:Agonists
3903:See also
3845:lecithin
3821:prodrugs
3791:WIN-2299
3767:loxapine
3453:Pridinol
3313:Metixene
3070:DAU-5884
3050:CS-27349
2970:Bevonium
2939:zotepine
2927:rilapine
2897:Atropine
2558:CDD-0102
2553:CDD-0098
2548:CDD-0097
2543:CDD-0078
2538:CDD-0034
2513:AQRA-741
2498:AF150(S)
2460:Agonists
2251:Edetates
2236:thallium
2156:Methanol
2081:Succimer
2040:against
2029:against
1994:Glucagon
1936:Naloxone
1921:Doxapram
1873:Diazepam
1863:Atropine
1802:overdose
1777:overdose
1765:Thiamine
1621:Archived
1566:17312211
1518:Archived
1506:19441874
1467:25935840
1426:28806470
1374:19821409
1343:18648227
1286:17048555
1259:34811540
1251:17312212
1210:17312188
1136:Archived
1079:Archived
1039:Archived
1035:DailyMed
1002:Archived
949:Archived
930:Archived
885:Scotland
827:Efficacy
779:atropine
622:(verify)
356:32689915
327:DrugBank
165:ATC code
140: B2
127:category
109:DailyMed
4953:Choline
4513:BW-A444
4491:(e.g.,
4484:BNC-210
4472:(e.g.,
4435:ABT-126
4419:(e.g.,
4378:XY-4083
4343:TC-6683
4338:TC-5619
4333:TC-5214
4328:TC-2216
4323:TC-1827
4318:TC-1734
4313:TC-1698
4223:NS-1738
4217:tobacco
4103:Choline
4048:ABT-894
4043:ABT-560
4038:ABT-418
4033:ABT-202
3841:Choline
3753:(e.g.,
3673:doxepin
3631:(e.g.,
3579:(e.g.,
3555:(e.g.,
3448:Poldine
3408:pFHHSiD
3333:Nefopam
3135:EA-3834
3130:EA-3580
3125:EA-3443
3120:EA-3167
2975:BIBN 99
2909:(e.g.,
2808:(e.g.,
2633:NGX-267
2613:McNA343
2568:Choline
2231:mercury
2221:cadmium
2172:Ethanol
2110:nitrite
2042:heparin
1741:Nervous
1627:10 June
1417:6483345
1167:19 June
1085:10 June
1045:10 June
1008:27 June
978:7 April
898:The US
875:History
773:agent (
747:Right:
712:at the
706:steroid
636:Bridion
496:Formula
336:DB06206
316:6918584
308:6918585
294:PubChem
220::
181:)
175: (
173:V03AB35
111::
63:Bridion
5048:Portal
4543:Curare
4460:AQW051
4407:18-MAC
4363:UB-165
4173:GTS-21
4003:5-HIAA
3971:nAChRs
3110:Ditran
2761:4-DAMP
2738:YM-796
2503:AF267B
2447:mAChRs
2352:WHO-EM
2318:Emetic
1977:system
1878:Oximes
1743:system
1564:
1512:
1504:
1465:
1424:
1414:
1372:
1341:
1284:
1257:
1249:
1208:
1112:6 June
571:SMILES
444:ChEMBL
405:D05940
247:℞-only
245:
232:
222:℞-only
208:
107:
4931:(and
4913:Xenon
4412:18-MC
4391:(and
3987:(and
3819:(and
3549:SSRIs
2473:AC-42
2264:Other
2060:Other
1732:V03AB
1617:(FDA)
1613:U.S.
1510:S2CID
1486:Drugs
1255:S2CID
1075:(EMA)
998:(emc)
893:Merck
660:Merck
591:InChI
547:JSmol
416:ChEBI
4593:DHβE
4394:NAMs
3990:PAMs
3383:PBID
3085:DIBD
2658:RS86
2493:AF30
2226:lead
1629:2020
1562:PMID
1502:PMID
1463:PMID
1422:PMID
1370:PMID
1339:PMID
1282:PMID
1247:PMID
1206:PMID
1169:2023
1114:2023
1087:2020
1047:2020
1010:2021
980:2024
819:and
646:and
395:KEGG
367:UNII
77:AHFS
3639:),
2925:),
1552:doi
1548:104
1494:doi
1453:doi
1449:115
1412:PMC
1404:doi
1362:doi
1329:doi
1325:109
1237:doi
1233:104
1196:doi
1192:104
883:in
808:or
777:or
765:so
683:or
662:.
650:in
538:.12
536:002
510:112
298:CID
234:POM
178:WHO
5074::
4495:,
4476:,
4427:,
4423:,
3773:,
3769:,
3765:,
3761:,
3757:,
3703:,
3699:,
3695:,
3691:,
3687:,
3683:,
3679:,
3675:,
3671:,
3667:,
3663:,
3659:,
3655:,
3651:,
3647:,
3643:,
3591:,
3587:,
3583:,
3559:,
3185:,
3181:,
2937:,
2933:,
2929:,
2917:,
2913:,
2884:,
2880:,
2876:,
2872:,
2868:,
2864:,
2860:,
2856:,
2852:,
2848:,
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2840:,
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2832:,
2828:,
2824:,
2820:,
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2365::
1611:.
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1542:.
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1500:.
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1231:.
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996:.
968:.
842:A
839:.
804:,
716:.
687:.
516:48
504:72
253:EU
241:US
228:UK
217:CA
210:S4
204:AU
136:AU
104:US
5050::
4959:)
4955:(
4935:)
4499:)
4480:)
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