594:"The American Heart Association recommends aspirin use for patients who've had a myocardial infarction (heart attack), unstable angina, ischemic stroke (caused by blood clot) or transient ischemic attacks (TIAs or "little strokes"), if not contraindicated. This recommendation is based on sound evidence from clinical trials showing that aspirin helps prevent the recurrence of such events as heart attack, hospitalization for recurrent angina, second strokes, etc. (secondary prevention). Studies show aspirin also helps prevent these events from occurring in people at high risk (primary prevention)."
239:; therefore, there is a balance shift toward inhibition of vasoconstriction and platelet aggregation. It is believed that this shift in balance lowers the incidence of myocardial infarction (heart attack) and stroke. Vasoconstriction and, perhaps, various proinflammatory effects exerted by TxA on tissue microvasculature, is probable reason why the TxA is pathogenic in various diseases, such as ischemia-reperfusion injury., hepatic inflammatory processes, acute hepatotoxicity etc. TxB2, a stable degradation product of TxA2, plays a role in acute hepatoxicity induced by acetaminophen.
86:
78:
20:
30:
302:
can induce near-complete suppression of platelet thromboxane throughout the dosing interval and appears not to increase cardiovascular disease (CVD) risk, whereas other high-dose NSAID (non-steroidal-anti-inflammatory) regimens have only transient effects on platelet
178:, platelets stick to the damaged lining of the vessel and to each other within seconds and form a plug. These "Sticky platelets" secrete several chemicals, including thromboxane A2 that stimulate vasoconstriction, reducing blood flow at the site.
1553:
273:. This anticoagulant property makes aspirin useful for reducing the incidence of heart attacks. 40 mg of aspirin a day is able to inhibit a large proportion of maximum thromboxane A
171:, a related compound. The mechanism of secretion of thromboxanes from platelets is still unclear. They act in the formation of blood clots and reduce blood flow to the site of a clot.
258:
acts by inhibiting the ability of the COX enzyme to synthesize the precursors of thromboxane within platelets. Low-dose, long-term aspirin use irreversibly blocks the formation of
649:
Dockens, RC; Santone, KS; Mitroka, JG; Morrison, RA; Jemal, M; Greene, DS; Barbhaiya, RH (Aug 2000). "Disposition of radiolabeled ifetroban in rats, dogs, monkeys, and humans".
606:
Tohgi, H; S Konno; K Tamura; B Kimura; K Kawano (1992). "Effects of low-to-high doses of aspirin on platelet aggregability and metabolites of thromboxane A2 and prostacyclin".
725:
Ratti, S; Quarato, P; Casagrande, C; Fumagalli, R; Corsini, A (1998). "Picotamide, an antithromboxane agent, inhibits the migration and proliferation of arterial myocytes".
1546:
277:
release provoked acutely, with the prostaglandin I2 synthesis being little affected; however, higher doses of aspirin are required to attain further inhibition.
678:"Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials"
247:
Thromboxane inhibitors are broadly classified as either those that inhibit the synthesis of thromboxane, or those that inhibit the target effect of it.
4083:
196:), produced by activated platelets, has prothrombotic properties, stimulating activation of new platelets as well as increasing platelet aggregation.
1539:
1092:
833:
402:
Ito Y (2003). "Effects of selective cyclooxygenase inhibitors on ischemia/reperfusion-induced hepatic microcirculatory dysfunction in mice".
445:
Katagiri H (2004). "Role of thromboxane derived from COX-1 and -2 in hepatic microcirculatory dysfunction during endotoxemia in mice".
762:"[Ridogrel, a new platelet antiaggregant molecule with a double mechanism of action. A pharmacological and clinical profile]"
368:
1055:
2529:
312:
280:
118:
tend to have increased thromboxane production, and analogs of thromboxane act as bronchoconstrictors in patients with asthma.
4076:
1149:
1668:
1611:
2182:
4033:
2091:
1976:
1899:
1792:
131:
1774:
1593:
826:
250:
Thromboxane synthesis inhibitors, in turn, can be classified regarding which step in the synthesis they inhibit:
2493:
3870:
3851:
3806:
2248:
805:
1576:
2634:
3912:
3832:
220:
93:
348:
3889:
2345:
1582:
1514:
1308:
1206:
961:
200:
175:
3394:
3364:
3195:
4105:
4028:
3150:
3003:
2473:
2311:
2220:
819:
284:
127:
2400:
2020:
3247:
3227:
2978:
2783:
2733:
1251:
3553:
3018:
2908:
2903:
2888:
2823:
2773:
2728:
2293:
3960:
3840:
3791:
3781:
3205:
2883:
2863:
2848:
2838:
2818:
2813:
2768:
2743:
2708:
2554:
2385:
2163:
2061:
2000:
1961:
1760:
1750:
1658:
1568:
631:
595:
470:
427:
295:
antagonizes this receptor too, but has various other mechanisms of antiplatelet activity as well.
224:
164:
3990:
3985:
3950:
3925:
3786:
3647:
3504:
3105:
3100:
2898:
2878:
2873:
2868:
2853:
2843:
2833:
2808:
2798:
2793:
2788:
2778:
2763:
2758:
2718:
2677:
2657:
2614:
2609:
2594:
2584:
2579:
2564:
2443:
2365:
2320:
2234:
2210:
2200:
1648:
325:
has activity both as a thromboxane synthase inhibitor and as a thromboxane receptor antagonist.
3975:
3930:
3741:
3687:
3672:
3521:
3232:
3180:
3065:
2913:
2858:
2828:
2803:
2753:
2748:
2738:
2723:
2672:
2667:
2624:
2559:
2549:
2519:
2463:
2433:
2390:
2380:
2229:
2153:
2005:
1918:
1715:
588:
3980:
3955:
3945:
3796:
3771:
3756:
3721:
3697:
3692:
3443:
3374:
3043:
3013:
2893:
2713:
2647:
2619:
2604:
2599:
2574:
2190:
2158:
2138:
2081:
1966:
1889:
1884:
1879:
1874:
1710:
1705:
781:
773:
742:
707:
658:
623:
571:
562:
Cavar I (2010). "The role of prostaglandin E2 in acute acetaminophen hepatotoxicity in mice".
511:
462:
419:
364:
328:
4000:
3716:
3662:
3657:
2692:
2539:
2448:
2405:
1956:
1869:
1755:
1735:
1730:
1725:
4056:
4048:
4043:
3862:
3766:
3761:
3347:
2933:
2569:
2534:
2424:
2410:
2370:
2303:
2129:
2120:
2052:
2043:
2035:
1937:
1928:
1850:
1841:
1692:
1630:
1505:
1485:
1465:
1457:
1408:
1341:
1302:
1257:
950:
939:
917:
891:
856:
734:
697:
689:
615:
542:
501:
454:
411:
356:
138:
105:
101:
2652:
2501:
531:"Anti-thromboxane B2 antibodies protect against acetaminophen-induced liver injury in mice"
3904:
3836:
3746:
3421:
3399:
3369:
2066:
930:
153:
801:
3426:
3379:
2944:
2506:
1565:
1442:
1434:
1393:
1373:
1365:
1357:
1324:
1316:
1289:
1281:
1273:
1265:
1116:
1108:
1100:
1079:
1071:
1022:
1014:
702:
677:
390:
360:
259:
186:
55:
51:
33:
23:
738:
693:
77:
4099:
4023:
3707:
3492:
3389:
3267:
3252:
3185:
3115:
875:
199:
Platelet aggregation is achieved by mediating expression of the glycoprotein complex
635:
474:
431:
85:
3563:
3480:
3406:
3384:
3337:
3272:
3242:
3222:
3217:
3140:
3028:
2453:
2415:
2283:
2110:
1946:
1831:
1638:
1416:
1349:
1335:
982:
292:
168:
19:
1531:
490:"Role of thromboxane in producing hepatic injury during a hepatic stress disorder"
307:
and have been found to be associated "with a small but definite vascular hazard".
4038:
3940:
3881:
3751:
3736:
3677:
3642:
3620:
3600:
3548:
3533:
3475:
3433:
3359:
3327:
3312:
3145:
3130:
3055:
2993:
2988:
2662:
2335:
2298:
2273:
2268:
2115:
2071:
2030:
2025:
1923:
1859:
1836:
1826:
1745:
1720:
1687:
1653:
1234:
1039:
219:
It is believed that the vasoconstriction caused by thromboxanes plays a role in
160:
47:
506:
489:
81:
Enzymes and substrates associated with thromoboxane and prostacyclin synthesis.
3970:
3731:
3702:
3682:
3635:
3630:
3615:
3590:
3558:
3526:
3497:
3453:
3352:
3302:
3297:
3292:
3287:
3262:
3175:
3170:
3110:
3095:
3075:
3060:
3033:
3008:
2998:
2983:
2973:
2687:
2642:
2629:
2544:
2330:
2325:
2278:
2215:
2195:
2148:
1740:
1562:
1498:
866:
842:
619:
322:
316:
204:
66:
777:
3995:
3935:
3667:
3625:
3610:
3605:
3595:
3585:
3580:
3575:
3570:
3485:
3468:
3463:
3458:
3342:
3322:
3317:
3282:
3277:
3237:
3210:
3165:
3160:
3155:
3135:
3090:
3085:
3048:
3038:
2963:
2682:
2589:
2438:
2375:
2288:
2205:
2010:
1995:
1816:
1811:
1427:
288:
135:
97:
29:
761:
711:
662:
575:
515:
466:
423:
785:
746:
676:
Coxib and traditional NSAID Trialists' (CNT) Collaboration (30 May 2013).
627:
156:
and a potent hypertensive agent, and it facilitates platelet aggregation.
3828:
3823:
3652:
3514:
3509:
3448:
3438:
3416:
3411:
3332:
3307:
3257:
3200:
3190:
3125:
3120:
3080:
2395:
2015:
1821:
1386:
1189:
1181:
1173:
1165:
547:
530:
299:
270:
266:
3965:
3776:
3543:
3070:
3023:
2968:
2514:
1225:
1218:
1214:
255:
207:
binds these receptors on adjacent platelets, further strengthening the
458:
415:
3726:
2927:
115:
43:
3538:
1478:
1133:
304:
59:
28:
18:
208:
1535:
815:
811:
391:
Rat kidney thromboxane receptor: molecular cloning, signal ...
58:. The distinguishing feature of thromboxanes is a 6-membered
311:
The inhibitors of the target effects of thromboxane are the
174:
If the cap of a vulnerable plaque erodes or ruptures, as in
291:
is a potent and selective thromboxane receptor antagonist.
65:
Thromboxane is named for its role in blood clot formation (
760:
Di Perri, T.; Notari, M.; Assogna, G. (October 1991).
4013:
3911:
3888:
3869:
3850:
3805:
2943:
2926:
2701:
2472:
2344:
2247:
2172:
2090:
1975:
1898:
1791:
1773:
1669:
1667:
1612:
1610:
1592:
1575:
1243:
1205:
1158:
1142:
1132:
1091:
1064:
1048:
1038:
1004:
975:
929:
910:
903:
884:
874:
865:
849:
2950:
2092:
1977:
1900:
1793:
1775:
1594:
3871:
3852:
3807:
2249:
227:are metabolized to produce higher levels of TxA
203:in the cell membrane of platelets. Circulating
3913:
3890:
2346:
1547:
827:
592:Aspirin in Heart Attack and Stroke Prevention
8:
2474:
2940:
1788:
1607:
1589:
1554:
1540:
1532:
1139:
1045:
907:
881:
871:
834:
820:
812:
347:Chung, Kian Fan; Barnes, Peter J. (2009).
231:, which is relatively less potent than TxA
126:Thromboxane acts by binding to any of the
804:at the U.S. National Library of Medicine
701:
546:
505:
84:
76:
339:
2945:
7:
3568:Selective COX-2 inhibitors (coxibs):
269:, producing an inhibitory effect on
1677:Tooltip Prostaglandin D2 receptor 2
1620:Tooltip Prostaglandin D2 receptor 1
287:) in the synthesis of thromboxane.
3539:AM-404 (N-arachidonoylaminophenol)
3357:Anthranilic acids (fenamic acids):
3009:Mesalazine (5-aminosalicylic acid)
2100:Tooltip Prostaglandin EP4 receptor
1985:Tooltip Prostaglandin EP3 receptor
1908:Tooltip Prostaglandin EP2 receptor
1801:Tooltip Prostaglandin EP1 receptor
361:10.1016/B978-0-12-374001-4.00052-3
182:Role of A2 in platelet aggregation
14:
4029:γ-Linolenic acid (gamolenic acid)
3375:Meclofenamic acid (meclofenamate)
1784:Tooltip Prostaglandin E2 receptor
1603:Tooltip Prostaglandin D2 receptor
1150:Arachidonic acid 15-hydroperoxide
50:. The two major thromboxanes are
4084:Leukotriene signaling modulators
3876:Tooltip Prostaglandin F synthase
3857:Tooltip Prostaglandin E synthase
3816:Tooltip Prostaglandin D synthase
2258:Tooltip Prostaglandin F receptor
1056:Arachidonic acid 5-hydroperoxide
727:European Journal of Pharmacology
3395:Talinflumic acid (talinflumate)
3385:Morniflumic acid (morniflumate)
3365:Floctafenic acid (floctafenate)
3348:Tiaprofenic acid (tiaprofenate)
651:Drug Metabolism and Disposition
313:thromboxane receptor antagonist
281:Thromboxane synthase inhibitors
3918:Tooltip Thromboxane A synthase
2969:Aspirin (acetylsalicylic acid)
2183:16,16-Dimethyl Prostaglandin E
1:
4077:Receptor/signaling modulators
3899:Tooltip Prostacyclin synthase
3400:Tolfenamic acid (tolfenamate)
3370:Flufenamic acid (flufenamate)
3360:Etofenamic acid (etofenamate)
2416:Prostacyclin (prostaglandin I
2355:Tooltip Prostacyclin receptor
766:Recenti Progressi in Medicina
739:10.1016/S0014-2999(98)00467-1
694:10.1016/S0140-6736(13)60900-9
42:is a member of the family of
2483:Tooltip Thromboxane receptor
590:American Heart Association:
3549:Paracetamol (acetaminophen)
3380:Mefenamic acid (mefenamate)
3034:Salicylate (salicylic acid)
987:(Prostacyclin/Epoprostenol)
132:G-protein-coupled receptors
4122:
3228:Bucloxic acid (blucloxate)
3146:Indometacin (indomethacin)
507:10.1001/archsurg.140.8.801
283:inhibit the final enzyme (
4068:
3390:Niflumic acid (niflumate)
2494:Carbocyclic thromboxane A
620:10.1161/01.STR.23.10.1400
3708:Menatetrenone (vitamin K
3531:Aminophenols (anilines):
806:Medical Subject Headings
4034:Dihomo-γ-linolenic acid
3431:Enolic acids (oxicams):
2974:Benorilate (benorylate)
3833:selenium tetrachloride
535:Journal of Xenobiotics
349:"Mediator Antagonists"
243:Thromboxane inhibitors
94:Thromboxane-A synthase
90:
82:
36:
26:
3502:Aminonicotinic acids:
254:The widely used drug
176:myocardial infarction
128:thromboxane receptors
96:, an enzyme found in
89:Eicosanoid synthesis.
88:
80:
32:
22:
3151:Indometacin farnesil
3004:Magnesium salicylate
2635:Pinane thromboxane A
2396:Iloprost (ciloprost)
2016:Iloprost (ciloprost)
1822:Iloprost (ciloprost)
548:10.4081/xeno.2011.e8
331:is another example.
285:thromboxane synthase
271:platelet aggregation
2979:Carbasalate calcium
1252:bronchoconstriction
488:Yokoyama Y (2005).
225:Omega-3 fatty acids
221:Prinzmetal's angina
3841:selenium disulfide
3473:4-Aminoquinolines:
564:Histol Histopathol
165:circulatory system
91:
83:
62:-containing ring.
37:
27:
4093:
4092:
4009:
4008:
3044:Sodium salicylate
3014:Methyl salicylate
2937:
2922:
2921:
2243:
2242:
1769:
1768:
1586:
1529:
1528:
1201:
1200:
1128:
1127:
1034:
1033:
1000:
999:
996:
995:
614:(10): 1400–1403.
459:10.1002/hep.20000
416:10.1159/000072174
152:Thromboxane is a
4113:
4044:Arachidonic acid
3919:
3915:
3900:
3896:
3877:
3873:
3858:
3854:
3817:
3813:
3640:Others/unsorted:
3215:Propionic acids:
3196:Sulindac sulfide
2961:Salicylic acids:
2952:
2947:
2941:
2931:
2484:
2480:
2356:
2352:
2259:
2255:
2101:
2097:
1986:
1982:
1909:
1905:
1802:
1798:
1789:
1785:
1781:
1678:
1674:
1621:
1617:
1608:
1604:
1600:
1590:
1580:
1556:
1549:
1542:
1533:
1303:vasoconstriction
1140:
1046:
908:
882:
872:
857:Arachidonic acid
836:
829:
822:
813:
790:
789:
757:
751:
750:
722:
716:
715:
705:
688:(9894): 769–79.
673:
667:
666:
646:
640:
639:
603:
597:
586:
580:
579:
559:
553:
552:
550:
529:Cavar I (2011).
526:
520:
519:
509:
485:
479:
478:
442:
436:
435:
399:
393:
388:
382:
381:
379:
377:
344:
111:to thromboxane.
102:arachidonic acid
4121:
4120:
4116:
4115:
4114:
4112:
4111:
4110:
4096:
4095:
4094:
4089:
4064:
4060:
4057:Prostaglandin H
4052:
4049:Prostaglandin G
4005:
3917:
3907:
3905:Tranylcypromine
3898:
3894:
3884:
3875:
3865:
3856:
3846:
3837:sodium selenite
3815:
3811:
3801:
3747:Rosmarinic acid
3711:
3519:Sulfonanilides:
3422:Oxyphenbutazone
2948:
2930:
2918:
2697:
2638:
2510:
2497:
2482:
2478:
2468:
2428:
2425:Prostaglandin E
2420:, epoprostenol)
2419:
2354:
2350:
2340:
2315:
2312:Prostaglandin F
2307:
2304:Prostaglandin D
2257:
2253:
2239:
2224:
2221:Prostaglandin F
2186:
2168:
2133:
2130:Prostaglandin E
2124:
2121:Prostaglandin E
2099:
2096:
2086:
2067:Ricinoleic acid
2056:
2053:Prostaglandin E
2047:
2044:Prostaglandin E
2039:
2036:Prostaglandin D
1984:
1981:
1971:
1941:
1938:Prostaglandin E
1932:
1929:Prostaglandin E
1907:
1904:
1894:
1854:
1851:Prostaglandin E
1845:
1842:Prostaglandin E
1800:
1797:
1783:
1779:
1765:
1696:
1693:Prostaglandin D
1676:
1673:
1663:
1634:
1631:Prostaglandin D
1619:
1616:
1602:
1598:
1579:
1571:
1560:
1530:
1525:
1518:
1509:
1489:
1469:
1461:
1446:
1438:
1420:
1412:
1397:
1377:
1369:
1361:
1353:
1345:
1328:
1320:
1312:
1293:
1285:
1277:
1269:
1261:
1239:
1229:
1222:
1197:
1193:
1185:
1177:
1169:
1154:
1124:
1120:
1112:
1104:
1087:
1083:
1075:
1060:
1030:
1026:
1018:
992:
986:
971:
965:
954:
943:
925:
921:
899:
895:
861:
845:
840:
798:
793:
772:(10): 533–540.
759:
758:
754:
724:
723:
719:
675:
674:
670:
648:
647:
643:
605:
604:
600:
587:
583:
561:
560:
556:
528:
527:
523:
487:
486:
482:
444:
443:
439:
401:
400:
396:
389:
385:
375:
373:
371:
353:Asthma and COPD
346:
345:
341:
337:
276:
263:
245:
238:
234:
230:
217:
195:
190:
184:
163:balance in the
154:vasoconstrictor
150:
142:
134:coupled to the
124:
109:
106:prostaglandin H
100:, converts the
75:
17:
16:Group of lipids
12:
11:
5:
4119:
4117:
4109:
4108:
4098:
4097:
4091:
4090:
4088:
4087:
4080:
4073:
4069:
4066:
4065:
4063:
4062:
4058:
4054:
4050:
4046:
4041:
4039:Diacylglycerol
4036:
4031:
4026:
4017:
4015:
4011:
4010:
4007:
4006:
4004:
4003:
3998:
3993:
3988:
3983:
3978:
3973:
3968:
3963:
3958:
3953:
3948:
3943:
3938:
3933:
3928:
3922:
3920:
3909:
3908:
3903:
3901:
3892:
3886:
3885:
3880:
3878:
3867:
3866:
3861:
3859:
3848:
3847:
3845:
3844:
3826:
3820:
3818:
3809:
3803:
3802:
3800:
3799:
3794:
3789:
3784:
3779:
3774:
3769:
3764:
3759:
3754:
3749:
3744:
3739:
3734:
3729:
3724:
3719:
3714:
3709:
3705:
3700:
3695:
3690:
3685:
3680:
3675:
3670:
3665:
3660:
3655:
3650:
3645:
3633:
3628:
3623:
3618:
3613:
3608:
3603:
3598:
3593:
3588:
3583:
3578:
3573:
3561:
3556:
3551:
3546:
3541:
3536:
3524:
3512:
3507:
3495:
3483:
3478:
3466:
3461:
3456:
3451:
3446:
3441:
3436:
3427:Phenylbutazone
3424:
3419:
3414:
3409:
3397:
3392:
3387:
3382:
3377:
3372:
3367:
3362:
3350:
3345:
3340:
3335:
3330:
3325:
3320:
3315:
3310:
3305:
3300:
3295:
3290:
3285:
3280:
3275:
3270:
3265:
3260:
3255:
3250:
3245:
3240:
3235:
3230:
3225:
3220:
3208:
3203:
3198:
3193:
3188:
3183:
3178:
3173:
3168:
3163:
3158:
3153:
3148:
3143:
3138:
3133:
3128:
3123:
3118:
3113:
3108:
3103:
3098:
3093:
3088:
3083:
3078:
3073:
3068:
3063:
3058:
3046:
3041:
3036:
3031:
3026:
3021:
3016:
3011:
3006:
3001:
2996:
2991:
2986:
2981:
2976:
2971:
2966:
2957:
2955:
2938:
2924:
2923:
2920:
2919:
2917:
2916:
2911:
2906:
2901:
2896:
2891:
2886:
2881:
2876:
2871:
2866:
2861:
2856:
2851:
2846:
2841:
2836:
2831:
2826:
2821:
2816:
2811:
2806:
2801:
2796:
2791:
2786:
2781:
2776:
2771:
2766:
2761:
2756:
2751:
2746:
2741:
2736:
2731:
2726:
2721:
2716:
2711:
2705:
2703:
2699:
2698:
2696:
2695:
2690:
2685:
2680:
2675:
2670:
2665:
2660:
2655:
2650:
2645:
2640:
2636:
2632:
2627:
2622:
2617:
2612:
2607:
2602:
2597:
2592:
2587:
2582:
2577:
2572:
2567:
2562:
2557:
2552:
2547:
2542:
2537:
2532:
2523:
2522:
2517:
2512:
2508:
2504:
2499:
2495:
2487:
2485:
2476:
2470:
2469:
2467:
2466:
2457:
2456:
2451:
2446:
2441:
2436:
2431:
2426:
2422:
2417:
2413:
2408:
2403:
2401:Isocarbacyclin
2398:
2393:
2388:
2383:
2378:
2373:
2368:
2359:
2357:
2348:
2342:
2341:
2339:
2338:
2333:
2328:
2323:
2318:
2313:
2309:
2305:
2301:
2296:
2291:
2286:
2281:
2276:
2271:
2262:
2260:
2251:
2245:
2244:
2241:
2240:
2238:
2237:
2232:
2227:
2222:
2218:
2213:
2208:
2203:
2198:
2193:
2188:
2184:
2176:
2174:
2170:
2169:
2167:
2166:
2161:
2156:
2151:
2142:
2141:
2136:
2134:(dinoprostone)
2131:
2127:
2122:
2118:
2113:
2104:
2102:
2094:
2088:
2087:
2085:
2084:
2075:
2074:
2069:
2064:
2059:
2057:(dinoprostone)
2054:
2050:
2045:
2041:
2037:
2033:
2028:
2023:
2021:Isocarbacyclin
2018:
2013:
2008:
2003:
1998:
1989:
1987:
1979:
1973:
1972:
1970:
1969:
1964:
1959:
1950:
1949:
1944:
1942:(dinoprostone)
1939:
1935:
1930:
1926:
1921:
1912:
1910:
1902:
1896:
1895:
1893:
1892:
1887:
1882:
1877:
1872:
1863:
1862:
1857:
1855:(dinoprostone)
1852:
1848:
1843:
1839:
1834:
1829:
1824:
1819:
1814:
1805:
1803:
1795:
1786:
1777:
1771:
1770:
1767:
1766:
1764:
1763:
1758:
1753:
1748:
1743:
1738:
1733:
1728:
1723:
1718:
1713:
1708:
1699:
1698:
1694:
1690:
1681:
1679:
1671:
1665:
1664:
1662:
1661:
1656:
1651:
1642:
1641:
1636:
1632:
1624:
1622:
1614:
1605:
1596:
1587:
1573:
1572:
1561:
1559:
1558:
1551:
1544:
1536:
1527:
1526:
1524:
1523:
1522:
1521:
1516:
1512:
1511:(Dinoprostone)
1507:
1494:
1493:
1492:
1491:
1487:
1474:
1473:
1472:
1471:
1467:
1463:
1459:
1450:
1449:
1448:
1444:
1440:
1436:
1424:
1423:
1422:
1418:
1414:
1410:
1401:
1400:
1399:
1395:
1382:
1381:
1380:
1379:
1375:
1371:
1367:
1363:
1359:
1355:
1351:
1347:
1343:
1332:
1331:
1330:
1326:
1322:
1318:
1314:
1310:
1298:
1297:
1296:
1295:
1291:
1287:
1283:
1279:
1275:
1271:
1267:
1263:
1259:
1247:
1245:
1241:
1240:
1238:
1237:
1232:
1227:
1220:
1211:
1209:
1203:
1202:
1199:
1198:
1196:
1195:
1191:
1187:
1183:
1179:
1175:
1171:
1167:
1162:
1160:
1156:
1155:
1153:
1152:
1146:
1144:
1137:
1130:
1129:
1126:
1125:
1123:
1122:
1118:
1114:
1110:
1106:
1102:
1097:
1095:
1089:
1088:
1086:
1085:
1081:
1077:
1073:
1068:
1066:
1062:
1061:
1059:
1058:
1052:
1050:
1043:
1036:
1035:
1032:
1031:
1029:
1028:
1024:
1020:
1016:
1011:
1009:
1002:
1001:
998:
997:
994:
993:
991:
990:
984:
979:
977:
973:
972:
970:
969:
963:
958:
957:
952:
947:
946:
944:(Dinoprostone)
941:
936:
934:
927:
926:
924:
923:
919:
914:
912:
905:
901:
900:
898:
897:
893:
888:
886:
879:
876:Prostaglandins
869:
863:
862:
860:
859:
853:
851:
847:
846:
841:
839:
838:
831:
824:
816:
810:
809:
797:
796:External links
794:
792:
791:
752:
717:
668:
641:
598:
581:
570:(7): 819–830.
554:
521:
480:
453:(1): 139–150.
437:
394:
383:
369:
338:
336:
333:
309:
308:
296:
278:
274:
261:
244:
241:
236:
232:
228:
216:
213:
193:
188:
183:
180:
149:
146:
140:
123:
120:
107:
74:
71:
56:thromboxane B2
52:thromboxane A2
34:Thromboxane B2
24:Thromboxane A2
15:
13:
10:
9:
6:
4:
3:
2:
4118:
4107:
4104:
4103:
4101:
4086:
4085:
4081:
4079:
4078:
4074:
4071:
4070:
4067:
4061:
4055:
4053:
4047:
4045:
4042:
4040:
4037:
4035:
4032:
4030:
4027:
4025:
4024:Linoleic acid
4022:
4019:
4018:
4016:
4012:
4002:
3999:
3997:
3994:
3992:
3989:
3987:
3984:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3952:
3949:
3947:
3944:
3942:
3939:
3937:
3934:
3932:
3929:
3927:
3924:
3923:
3921:
3916:
3910:
3906:
3902:
3897:
3887:
3883:
3879:
3874:
3868:
3864:
3860:
3855:
3849:
3842:
3838:
3834:
3830:
3827:
3825:
3822:
3821:
3819:
3814:
3804:
3798:
3795:
3793:
3790:
3788:
3785:
3783:
3780:
3778:
3775:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3753:
3750:
3748:
3745:
3743:
3740:
3738:
3735:
3733:
3730:
3728:
3725:
3723:
3720:
3718:
3715:
3713:
3706:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3684:
3681:
3679:
3676:
3674:
3671:
3669:
3666:
3664:
3661:
3659:
3656:
3654:
3651:
3649:
3646:
3644:
3641:
3637:
3634:
3632:
3629:
3627:
3624:
3622:
3619:
3617:
3614:
3612:
3609:
3607:
3604:
3602:
3599:
3597:
3594:
3592:
3589:
3587:
3584:
3582:
3579:
3577:
3574:
3572:
3569:
3565:
3562:
3560:
3557:
3555:
3552:
3550:
3547:
3545:
3542:
3540:
3537:
3535:
3532:
3528:
3525:
3523:
3520:
3516:
3513:
3511:
3508:
3506:
3503:
3499:
3496:
3494:
3493:Fluproquazone
3491:
3490:Quinazolines:
3487:
3484:
3482:
3479:
3477:
3474:
3470:
3467:
3465:
3462:
3460:
3457:
3455:
3452:
3450:
3447:
3445:
3442:
3440:
3437:
3435:
3432:
3428:
3425:
3423:
3420:
3418:
3415:
3413:
3410:
3408:
3405:
3401:
3398:
3396:
3393:
3391:
3388:
3386:
3383:
3381:
3378:
3376:
3373:
3371:
3368:
3366:
3363:
3361:
3358:
3354:
3351:
3349:
3346:
3344:
3341:
3339:
3336:
3334:
3331:
3329:
3326:
3324:
3321:
3319:
3316:
3314:
3311:
3309:
3306:
3304:
3301:
3299:
3296:
3294:
3291:
3289:
3286:
3284:
3281:
3279:
3276:
3274:
3271:
3269:
3268:Flunoxaprofen
3266:
3264:
3261:
3259:
3256:
3254:
3253:Dexketoprofen
3251:
3249:
3248:Dexindoprofen
3246:
3244:
3241:
3239:
3236:
3234:
3231:
3229:
3226:
3224:
3221:
3219:
3216:
3212:
3209:
3207:
3204:
3202:
3199:
3197:
3194:
3192:
3189:
3187:
3186:Proglumetacin
3184:
3182:
3179:
3177:
3174:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3127:
3124:
3122:
3119:
3117:
3116:Difenpiramide
3114:
3112:
3109:
3107:
3104:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3084:
3082:
3079:
3077:
3074:
3072:
3069:
3067:
3064:
3062:
3059:
3057:
3054:
3053:Acetic acids:
3050:
3047:
3045:
3042:
3040:
3037:
3035:
3032:
3030:
3027:
3025:
3022:
3020:
3017:
3015:
3012:
3010:
3007:
3005:
3002:
3000:
2997:
2995:
2992:
2990:
2987:
2985:
2982:
2980:
2977:
2975:
2972:
2970:
2967:
2965:
2962:
2959:
2958:
2956:
2954:
2942:
2939:
2935:
2929:
2925:
2915:
2912:
2910:
2907:
2905:
2902:
2900:
2897:
2895:
2892:
2890:
2887:
2885:
2882:
2880:
2877:
2875:
2872:
2870:
2867:
2865:
2862:
2860:
2857:
2855:
2852:
2850:
2847:
2845:
2842:
2840:
2837:
2835:
2832:
2830:
2827:
2825:
2822:
2820:
2817:
2815:
2812:
2810:
2807:
2805:
2802:
2800:
2797:
2795:
2792:
2790:
2787:
2785:
2784:Fenprostalene
2782:
2780:
2777:
2775:
2772:
2770:
2767:
2765:
2762:
2760:
2757:
2755:
2752:
2750:
2747:
2745:
2742:
2740:
2737:
2735:
2734:Delprostenate
2732:
2730:
2727:
2725:
2722:
2720:
2717:
2715:
2712:
2710:
2707:
2706:
2704:
2700:
2694:
2691:
2689:
2686:
2684:
2681:
2679:
2676:
2674:
2671:
2669:
2666:
2664:
2661:
2659:
2656:
2654:
2651:
2649:
2646:
2644:
2641:
2639:
2633:
2631:
2628:
2626:
2623:
2621:
2618:
2616:
2613:
2611:
2608:
2606:
2603:
2601:
2598:
2596:
2593:
2591:
2588:
2586:
2583:
2581:
2578:
2576:
2573:
2571:
2568:
2566:
2563:
2561:
2558:
2556:
2553:
2551:
2548:
2546:
2543:
2541:
2538:
2536:
2533:
2531:
2528:
2525:
2524:
2521:
2518:
2516:
2513:
2511:
2507:Thromboxane A
2505:
2503:
2500:
2498:
2492:
2489:
2488:
2486:
2481:
2471:
2465:
2462:
2459:
2458:
2455:
2452:
2450:
2447:
2445:
2442:
2440:
2437:
2435:
2432:
2430:
2429:(alprostadil)
2423:
2421:
2414:
2412:
2409:
2407:
2404:
2402:
2399:
2397:
2394:
2392:
2389:
2387:
2384:
2382:
2379:
2377:
2374:
2372:
2369:
2367:
2364:
2361:
2360:
2358:
2353:
2343:
2337:
2334:
2332:
2329:
2327:
2324:
2322:
2319:
2317:
2310:
2308:
2302:
2300:
2297:
2295:
2292:
2290:
2287:
2285:
2282:
2280:
2277:
2275:
2272:
2270:
2267:
2264:
2263:
2261:
2256:
2246:
2236:
2233:
2231:
2228:
2226:
2219:
2217:
2214:
2212:
2209:
2207:
2204:
2202:
2199:
2197:
2194:
2192:
2189:
2187:
2181:
2178:
2177:
2175:
2171:
2165:
2162:
2160:
2157:
2155:
2152:
2150:
2147:
2144:
2143:
2140:
2137:
2135:
2128:
2126:
2125:(alprostadil)
2119:
2117:
2114:
2112:
2109:
2106:
2105:
2103:
2098:
2089:
2083:
2080:
2077:
2076:
2073:
2070:
2068:
2065:
2063:
2060:
2058:
2051:
2049:
2048:(alprostadil)
2042:
2040:
2034:
2032:
2029:
2027:
2024:
2022:
2019:
2017:
2014:
2012:
2009:
2007:
2004:
2002:
1999:
1997:
1994:
1991:
1990:
1988:
1983:
1974:
1968:
1965:
1963:
1960:
1958:
1955:
1952:
1951:
1948:
1945:
1943:
1936:
1934:
1933:(alprostadil)
1927:
1925:
1922:
1920:
1917:
1914:
1913:
1911:
1906:
1897:
1891:
1888:
1886:
1883:
1881:
1878:
1876:
1873:
1871:
1868:
1865:
1864:
1861:
1858:
1856:
1849:
1847:
1846:(alprostadil)
1840:
1838:
1835:
1833:
1830:
1828:
1825:
1823:
1820:
1818:
1815:
1813:
1810:
1807:
1806:
1804:
1799:
1790:
1787:
1782:
1772:
1762:
1759:
1757:
1754:
1752:
1749:
1747:
1744:
1742:
1739:
1737:
1734:
1732:
1729:
1727:
1724:
1722:
1719:
1717:
1714:
1712:
1709:
1707:
1704:
1701:
1700:
1697:
1691:
1689:
1686:
1683:
1682:
1680:
1675:
1666:
1660:
1657:
1655:
1652:
1650:
1647:
1644:
1643:
1640:
1637:
1635:
1629:
1626:
1625:
1623:
1618:
1609:
1606:
1601:
1591:
1588:
1584:
1578:
1574:
1570:
1567:
1564:
1557:
1552:
1550:
1545:
1543:
1538:
1537:
1534:
1519:
1513:
1510:
1504:
1503:
1502:
1500:
1496:
1495:
1490:
1484:
1483:
1482:
1480:
1476:
1475:
1470:
1464:
1462:
1456:
1455:
1454:
1451:
1447:
1441:
1439:
1433:
1432:
1431:
1429:
1425:
1421:
1415:
1413:
1407:
1406:
1405:
1402:
1398:
1392:
1391:
1390:
1388:
1384:
1383:
1378:
1372:
1370:
1364:
1362:
1356:
1354:
1348:
1346:
1340:
1339:
1338:
1337:
1333:
1329:
1323:
1321:
1315:
1313:
1307:
1306:
1305:
1304:
1300:
1299:
1294:
1288:
1286:
1280:
1278:
1272:
1270:
1264:
1262:
1256:
1255:
1254:
1253:
1249:
1248:
1246:
1242:
1236:
1233:
1230:
1223:
1216:
1213:
1212:
1210:
1208:
1204:
1194:
1188:
1186:
1180:
1178:
1172:
1170:
1164:
1163:
1161:
1157:
1151:
1148:
1147:
1145:
1141:
1138:
1135:
1131:
1121:
1115:
1113:
1107:
1105:
1099:
1098:
1096:
1094:
1090:
1084:
1078:
1076:
1070:
1069:
1067:
1063:
1057:
1054:
1053:
1051:
1047:
1044:
1041:
1037:
1027:
1021:
1019:
1013:
1012:
1010:
1007:
1003:
988:
981:
980:
978:
974:
967:
960:
959:
956:
955:(Alprostadil)
949:
948:
945:
938:
937:
935:
932:
928:
922:
916:
915:
913:
909:
906:
902:
896:
890:
889:
887:
883:
880:
877:
873:
870:
868:
864:
858:
855:
854:
852:
848:
844:
837:
832:
830:
825:
823:
818:
817:
814:
807:
803:
800:
799:
795:
787:
783:
779:
775:
771:
767:
763:
756:
753:
748:
744:
740:
736:
732:
728:
721:
718:
713:
709:
704:
699:
695:
691:
687:
683:
679:
672:
669:
664:
660:
657:(8): 973–80.
656:
652:
645:
642:
637:
633:
629:
625:
621:
617:
613:
609:
602:
599:
596:
593:
589:
585:
582:
577:
573:
569:
565:
558:
555:
549:
544:
540:
536:
532:
525:
522:
517:
513:
508:
503:
499:
495:
491:
484:
481:
476:
472:
468:
464:
460:
456:
452:
448:
441:
438:
433:
429:
425:
421:
417:
413:
410:(5): 408–16.
409:
405:
398:
395:
392:
387:
384:
372:
370:9780123740014
366:
362:
358:
354:
350:
343:
340:
334:
332:
330:
326:
324:
320:
318:
314:
306:
301:
297:
294:
290:
286:
282:
279:
272:
268:
264:
260:thromboxane A
257:
253:
252:
251:
248:
242:
240:
226:
222:
214:
212:
210:
206:
202:
197:
191:
187:Thromboxane A
181:
179:
177:
172:
170:
166:
162:
157:
155:
147:
145:
143:
137:
133:
129:
121:
119:
117:
112:
110:
103:
99:
95:
87:
79:
72:
70:
68:
63:
61:
57:
53:
49:
45:
41:
35:
31:
25:
21:
4082:
4075:
4020:
3639:
3567:
3564:Propacetamol
3554:Parapropamol
3530:
3518:
3501:
3489:
3481:Floctafenine
3472:
3430:
3407:Azapropazone
3404:Pyrazolones:
3403:
3356:
3338:Tarenflurbil
3273:Flurbiprofen
3243:Dexibuprofen
3223:Benoxaprofen
3218:Alminoprofen
3214:
3141:Glucametacin
3052:
3029:Salicylamide
3019:Salacetamide
2960:
2909:Trimoprostil
2904:Tiprostanide
2889:Spiriprostil
2824:Naxaprostene
2774:Esuberaprost
2729:Cobiprostone
2527:Antagonists:
2526:
2490:
2461:Antagonists:
2460:
2454:Treprostinil
2362:
2294:Fluprostenol
2284:Cloprostenol
2265:
2179:
2146:Antagonists:
2145:
2111:Lubiprostone
2107:
2079:Antagonists:
2078:
1992:
1954:Antagonists:
1953:
1947:Treprostinil
1915:
1867:Antagonists:
1866:
1832:Lubiprostone
1808:
1703:Antagonists:
1702:
1684:
1646:Antagonists:
1645:
1639:Treprostinil
1627:
1501:stimulation:
1497:
1481:stimulation:
1477:
1452:
1426:
1403:
1385:
1336:vasodilation
1334:
1301:
1250:
1040:Leukotrienes
1006:Thromboxanes
1005:
802:Thromboxanes
769:
765:
755:
733:(1): 77–83.
730:
726:
720:
685:
681:
671:
654:
650:
644:
611:
607:
601:
591:
584:
567:
563:
557:
541:(1): 38–44.
538:
534:
524:
500:(8): 801–7.
497:
493:
483:
450:
446:
440:
407:
404:Eur Surg Res
403:
397:
386:
374:. Retrieved
352:
342:
327:
321:
315:, including
310:
293:Dipyridamole
249:
246:
218:
198:
185:
173:
169:prostacyclin
158:
151:
125:
114:People with
113:
92:
64:
39:
38:
4106:Eicosanoids
4021:Precursors:
3961:Nicogrelate
3941:Furegrelate
3882:Bimatoprost
3792:Trifenagrel
3782:Tiflamizole
3752:Rutecarpine
3737:Resveratrol
3678:Glimepiride
3643:Anitrazafen
3621:Robenacoxib
3601:Lumiracoxib
3534:Acetanilide
3476:Antrafenine
3434:Ampiroxicam
3328:Pranoprofen
3313:Naproxcinod
3206:Zidometacin
3131:Fenclofenac
3056:Aceclofenac
2994:Ethenzamide
2989:Dipyrocetyl
2884:Rosaprostol
2864:Posaraprost
2849:Penprostene
2839:Ornoprostil
2819:Mexiprostil
2814:Meteneprost
2769:Eptaloprost
2744:Dimoxaprost
2709:Arbaprostil
2663:Seratrodast
2555:BMS-180,291
2386:Carbacyclin
2336:Unoprostone
2316:(dinoprost)
2299:Latanoprost
2274:Bimatoprost
2269:Alfaprostol
2225:(dinoprost)
2164:ONO-AE3-208
2116:Misoprostol
2072:Sulprostone
2062:Remiprostol
2031:Misoprostol
2026:Latanoprost
2001:Carbacyclin
1962:PF-04418948
1924:Misoprostol
1860:Sulprostone
1837:Misoprostol
1827:Latanoprost
1761:Vidupiprant
1751:Timapiprant
1746:Setipiprant
1721:Fevipiprant
1688:Indometacin
1659:Vidupiprant
1654:Laropiprant
1520:(Dinoprost)
1244:By function
1235:Virodhamine
966:(Dinoprost)
867:Prostanoids
843:Eicosanoids
355:: 655–662.
201:GP IIb/IIIa
161:homeostatic
104:derivative
48:eicosanoids
40:Thromboxane
3991:Samixogrel
3986:Rolafagrel
3971:Picotamide
3951:Midazogrel
3926:Camonagrel
3787:Timegadine
3732:Pamicogrel
3703:Licofelone
3683:Hyperforin
3648:Clobuzarit
3636:Valdecoxib
3631:Tilmacoxib
3616:Polmacoxib
3591:Etoricoxib
3559:Phenacetin
3527:Nimesulide
3505:Clonixeril
3498:Proquazone
3454:Lornoxicam
3353:Vedaprofen
3303:Miroprofen
3298:Loxoprofen
3293:Ketoprofen
3288:Indoprofen
3263:Fenoprofen
3176:Oxametacin
3171:Nabumetone
3111:Diclofenac
3106:Clometacin
3101:Cinmetacin
3096:Bumadizone
3076:Alclofenac
3061:Acemetacin
2999:Guacetisal
2984:Diflunisal
2934:inhibitors
2899:Tilsuprost
2879:Rivenprost
2874:Rioprostil
2869:Prostalene
2854:Pimilprost
2844:Oxoprostol
2834:Nocloprost
2809:Luprostiol
2799:Lanproston
2794:Froxiprost
2789:Flunoprost
2779:Etiproston
2764:Enisoprost
2759:Eganoprost
2719:Ciprostene
2688:Terutroban
2678:Sulotroban
2658:Samixogrel
2643:Ramatroban
2630:Picotamide
2615:Mipitroban
2610:Linotroban
2595:Imitrodast
2585:ICI-192605
2580:ICI-185282
2565:Domitroban
2545:Argatroban
2444:Taprostene
2366:ACT-333679
2331:Travoprost
2326:Tafluprost
2321:Sulotroban
2279:Carboprost
2235:Taprenepag
2216:Omidenepag
2211:Nocloprost
2201:Evatanepag
2196:Carboprost
2149:Grapiprant
1741:Ramatroban
1649:Asapiprant
1569:modulators
1563:Prostanoid
1428:leukocytes
1207:Nonclassic
494:Arch. Surg
447:Hepatology
376:20 January
335:References
323:Picotamide
317:terutroban
298:High-dose
205:fibrinogen
73:Production
67:thrombosis
3996:Terbogrel
3976:Pirmagrel
3936:Dazoxiben
3931:Dazmegrel
3824:Retinoids
3742:Romazarit
3688:Itazigrel
3673:FR-122047
3668:Flumizole
3626:Rofecoxib
3611:Parecoxib
3606:Mavacoxib
3596:Firocoxib
3586:Deracoxib
3581:Cimicoxib
3576:Celecoxib
3571:Apricoxib
3522:Flosulide
3486:Glafenine
3469:Tenoxicam
3464:Piroxicam
3459:Meloxicam
3343:Tepoxalin
3323:Pirprofen
3318:Oxaprozin
3283:Ibuproxam
3278:Ibuprofen
3238:Carprofen
3233:Butibufen
3211:Zomepirac
3181:Oxindanac
3166:Mofezolac
3161:Lonazolac
3156:Ketorolac
3136:Fentiazac
3091:Bufexamac
3086:Bromfenac
3066:Aclofenac
3049:Triflusal
3039:Salsalate
2964:Aloxiprin
2914:Viprostol
2859:Piriprost
2829:Nileprost
2804:Limaprost
2754:Ecraprost
2749:Doxaprost
2739:Deprostil
2724:Clinprost
2683:Terbogrel
2673:SQ-29,548
2668:SQ-28,668
2625:ONO-11120
2590:Ifetroban
2560:Daltroban
2550:Bay U3405
2520:Vapiprost
2491:Agonists:
2464:RO1138452
2439:Selexipag
2434:Ralinepag
2391:Cicaprost
2381:BMY-45778
2376:Beraprost
2363:Agonists:
2289:Enprostil
2266:Agonists:
2230:Simenepag
2206:Gemeprost
2180:Agonists:
2154:GW-627368
2108:Agonists:
2011:Enprostil
2006:Cicaprost
1996:Beraprost
1993:Agonists:
1919:Butaprost
1916:Agonists:
1817:Enprostil
1812:Beraprost
1809:Agonists:
1716:Bay U3405
1685:Agonists:
1628:Agonists:
1566:signaling
1387:platelets
1143:Precursor
1049:Precursor
885:Precursor
850:Precursor
778:0034-1193
289:Ifetroban
267:platelets
215:Pathology
159:It is in
148:Functions
136:G protein
122:Mechanism
98:platelets
46:known as
4100:Category
4072:See also
3981:Ridogrel
3956:Nafagrel
3946:Isbogrel
3829:Selenium
3797:Tropesin
3772:SC-58125
3757:Satigrel
3722:NCX-4040
3698:L-670596
3693:L-655240
3653:Curcumin
3515:Flunixin
3510:Clonixin
3449:Isoxicam
3444:Enolicam
3439:Droxicam
3417:Isopyrin
3412:Dipyrone
3333:Suprofen
3308:Naproxen
3258:Fenbufen
3201:Tolmetin
3191:Sulindac
3126:Felbinac
3121:Etodolac
3081:Bendazac
2894:Tiaprost
2714:Ataprost
2702:Unsorted
2648:Ridogrel
2620:ONO-3708
2605:L-670596
2600:L-655240
2575:GR-32191
2191:Aganepag
2173:Unsorted
2159:L-161982
2139:TCS-2510
2082:L-798106
1967:TG 4-155
1890:SC-51322
1885:SC-51089
1880:SC-19220
1875:ONO-8130
1711:AZD-1981
1706:ADC-3680
1577:Receptor
1430:: induce
1389:: induce
1215:Lipoxins
712:23726390
663:10901709
636:14177039
576:20503171
516:16103291
475:27252438
467:14752832
432:40932766
424:12928598
329:Ridogrel
300:naproxen
4001:U63557A
3966:Ozagrel
3777:Tenidap
3717:NCX-466
3663:FK-3311
3658:DuP-697
3544:Bucetin
3071:Amfenac
3024:Salicin
2693:TRA-418
2540:AA-2414
2530:12-HETE
2515:U-46619
2449:TRA-418
2406:MRE-269
1957:AH-6809
1870:AH-6809
1756:TM30089
1736:QAV-680
1731:MK-7246
1726:MK-1029
1583:ligands
1453:inhibit
1404:inhibit
1065:Initial
786:1759039
747:9754941
703:3778977
628:1412574
256:aspirin
235:and PGI
4014:Others
3863:HQL-79
3767:SC-560
3762:SC-236
3727:NS-398
2928:Enzyme
2570:EP-045
2535:13-APA
2475:TP (TX
2411:NS-304
2371:AFP-07
1217:(LX) (
1159:Eoxins
1134:Eoxins
904:Active
808:(MeSH)
784:
776:
745:
710:
700:
682:Lancet
661:
634:
626:
608:Stroke
574:
514:
473:
465:
430:
422:
367:
116:asthma
44:lipids
2653:S-145
2502:I-BOP
2347:IP (I
2250:FP (F
1776:EP (E
1595:DP (D
1499:labor
1479:fever
1093:SRS-A
632:S2CID
471:S2CID
428:S2CID
305:COX-1
167:with
60:ether
3914:TXAS
3872:PGFS
3853:PGES
2951:PTGS
1136:(EX)
1042:(LT)
1008:(TX)
878:(PG)
782:PMID
774:ISSN
743:PMID
708:PMID
659:PMID
624:PMID
572:PMID
512:PMID
463:PMID
420:PMID
378:2023
365:ISBN
209:clot
192:(TXA
54:and
3891:PGI
3808:PGD
2946:COX
1515:PGF
1506:PGE
1486:PGE
1466:PGE
1458:PGD
1443:LTB
1435:TXA
1417:PGI
1409:PGD
1394:TXA
1374:LTE
1366:LTD
1358:LTC
1350:PGI
1342:PGE
1325:TXB
1317:TXA
1309:PGF
1290:LTE
1282:LTD
1274:LTC
1266:TXA
1258:PGD
911:D/J
735:doi
731:355
698:PMC
690:doi
686:382
616:doi
543:doi
502:doi
498:140
455:doi
412:doi
357:doi
265:in
69:).
4102::
3839:,
3835:,
3638:;
3566:;
3529:;
3517:;
3500:;
3488:;
3471:;
3429:;
3402:;
3355:;
3213:;
3051:;
2477:A2
2314:2α
2252:2α
2223:2α
2093:EP
1978:EP
1901:EP
1794:EP
1670:DP
1613:DP
1517:2α
1311:2α
1224:,
964:2α
933:/F
780:.
770:82
768:.
764:.
741:.
729:.
706:.
696:.
684:.
680:.
655:28
653:.
630:.
622:.
612:23
610:.
568:25
566:.
537:.
533:.
510:.
496:.
492:.
469:.
461:.
451:39
449:.
426:.
418:.
408:35
406:.
363:.
351:.
319:.
223:.
211:.
144:.
130:,
4059:2
4051:2
3895:S
3893:2
3843:)
3831:(
3812:S
3810:2
3712:)
3710:2
2953:)
2949:(
2936:)
2932:(
2637:2
2509:2
2496:2
2479:)
2427:1
2418:2
2351:)
2349:2
2306:2
2254:)
2185:2
2132:2
2123:1
2095:4
2055:2
2046:1
2038:2
1980:3
1940:2
1931:1
1903:2
1853:2
1844:1
1796:1
1780:)
1778:2
1695:2
1672:2
1633:2
1615:1
1599:)
1597:2
1585:)
1581:(
1555:e
1548:t
1541:v
1508:2
1488:2
1468:2
1460:2
1445:4
1437:2
1419:2
1411:2
1396:2
1376:4
1368:4
1360:4
1352:2
1344:2
1327:2
1319:2
1292:4
1284:4
1276:4
1268:2
1260:2
1231:)
1228:4
1226:B
1221:4
1219:A
1192:4
1190:E
1184:4
1182:D
1176:4
1174:C
1168:4
1166:A
1119:4
1117:E
1111:4
1109:D
1103:4
1101:C
1082:4
1080:B
1074:4
1072:A
1025:2
1023:B
1017:2
1015:A
989::
985:2
983:I
976:I
968::
962:F
953:1
951:E
942:2
940:E
931:E
920:2
918:D
894:2
892:H
835:e
828:t
821:v
788:.
749:.
737::
714:.
692::
665:.
638:.
618::
578:.
551:.
545::
539:1
518:.
504::
477:.
457::
434:.
414::
380:.
359::
275:2
262:2
237:3
233:2
229:3
194:2
189:2
141:q
139:G
108:2
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
