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641:. It is usually administered 3 or 4 times daily, with the total daily dose ranging from 900 mg to 2.4 g. Treatment is most effective when the concentration of its active metabolite, dimethadione, is above 700 μg/mL. Severe adverse reactions are possible, including
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may result causing facial dysmorphism (short upturned nose, slanted eyebrows), cardiac defects,
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This article is about the drug
Tridione. For the content management software Tridion, see
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while using trimethadione has been reported to be as high as 87%.
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665:. More common adverse effects include drowsiness,
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685:(IUGR), and mental retardation. The fetal
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741:Pharmacology and Drug Therapy in Nursing
80:Micromedex Detailed Consumer Information
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633:It is primarily effective in treating
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683:intrauterine growth restriction
590:Key:IRYJRGCIQBGHIV-UHFFFAOYSA-N
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1510:. You can help Knowledge by
739:Rodman MJ, Smith DW (1979).
679:fetal trimethadione syndrome
673:Fetal trimethadione syndrome
743:. Lippincott. p. 259.
204:12–24 hours (trimethadione)
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484:Chemical and physical data
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206:6–13 days (dimethadione)
1181:Eslicarbazepine acetate
643:Steven Johnson syndrome
1506:-related article is a
766:Retrieved January 2007
639:temporal lobe epilepsy
1567:Anticonvulsant stubs
780:MedlinePlus DrugInfo
708:AMA Drug Evaluations
565:O=C1N(C(=O)OC1(C)C)C
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1477:Never to phase III
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790:Diseases Database
784:medmaster-a601127
750:978-0-39754-230-7
717:978-0-88416-175-2
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39:Trimethadione
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1512:expanding it
1501:
1423:Fenfluramine
1403:Brivaracetam
1352:Sulfonamides
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1267:Phensuximide
1257:Ethosuximide
1252:Succinimides
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1169:Carboxamides
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197:Elimination
190:dimethadione
150:Legal status
144:Legal status
1463:from market
1413:Carisbamate
1408:Cannabidiol
1294:Lamotrigine
1198:Lamotrigine
1149:Fatty acids
1144:Pheneturide
1139:Phenacemide
1114:Mephenytoin
1013:Fatty acids
994:Stiripentol
989:Paraldehyde
953:Nimetazepam
933:Clorazepate
878:Metharbital
667:hemeralopia
659:neutropenia
527: g·mol
473:100.004.406
223:Identifiers
60:Trade names
1551:Categories
1438:Perampanel
1428:Ganaxolone
1418:Etiracetam
1377:Zonisamide
1372:Topiramate
1322:Retigabine
1304:Zonisamide
1299:Topiramate
1282:Pregabalin
1277:Gabapentin
1262:Mesuximide
1213:Zonisamide
1208:Topiramate
1203:Rufinamide
1193:Lacosamide
1159:Valpromide
1099:Hydantoins
1081:modulators
1033:Vigabatrin
1023:Valpromide
958:Nitrazepam
928:Clonazepam
908:Cenobamate
903:Carbamates
843:GABAergics
726:1024170745
693:References
532:3D model (
520:Molar mass
403:CHEBI:9727
363:R7GV3H6FQ4
334:ChemSpider
294:IUPHAR/BPS
249:CAS Number
232:IUPAC name
184:Metabolism
1473:Phase III
1461:Withdrawn
1398:Beclamide
1289:Imepitoin
1237:Ethadione
1154:Valproate
1119:Phenytoin
1065:Tiagabine
1055:Progabide
1018:Valproate
984:Imepitoin
963:Temazepam
948:Midazolam
943:Lorazepam
913:Felbamate
898:Primidone
687:loss rate
651:hepatitis
628:epileptic
423:ChEMBL695
212:Excretion
199:half-life
106:Routes of
88:Pregnancy
74:Drugs.com
1393:Albutoin
1367:Sultiame
1104:Ethotoin
938:Diazepam
923:Clobazam
619:) is an
617:Tridione
603:(verify)
314:DrugBank
258:127-48-0
120:ATC code
113:By mouth
90:category
64:Tridione
1286:Others:
1190:Others:
1124:Ureides
1079:Channel
970:Bromide
967:Others:
792:(DDB):
525:143.142
490:Formula
323:DB00347
269:PubChem
136:)
130: (
128:N03AC02
32:SDL plc
18:Tridion
1456:WHO-EM
1386:Others
1335:Others
1042:Others
747:
724:
714:
558:SMILES
414:ChEMBL
383:D00392
1502:This
794:30479
661:, or
578:InChI
534:JSmol
394:ChEBI
217:Renal
1508:stub
859:PAMs
852:GABA
745:ISBN
722:OCLC
712:ISBN
374:KEGG
354:UNII
343:5374
303:7316
283:5576
178:High
168:data
70:AHFS
834:N03
439:EPA
273:CID
133:WHO
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728:.
615:(
536:)
513:3
510:O
507:N
504:9
501:H
498:6
495:C
441:)
437:(
97:X
72:/
34:.
20:)
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