424:. The genotypes can be distinguished based on the F, SH, are HN genes. The SH gene has a degree of variation between genotypes ranging from 5% to 21%, the highest among MuV's genes. The genotypes are named genotypes A to N, excluding E and M, i.e. genotypes A, B, C, D, F, G, H, I, J, K, L, and N. Genotypes E and M were previously recognized but were abolished due to phylogenetic analysis that MuVs assigned to them instead belonged genotypes C and K, respectively.
63:
364:, which binds to sialic acid receptors on the surface of host cells. Following attachment, the F protein is triggered and begins fusing the viral envelope with the host cell's membrane. The F protein does so by changing from a metastable state to refolding to a more stable hairpin structure, which allows the contents of the virion, including the RNP, to be released into the host cell's cytoplasm.
408:
form of a vesicle that protrudes from the cell. The ESCRT proteins then constrict the opening of the vesicle and terminate budding by cutting off the vesicle from the rest of the membrane, forming a complete virion that is released from the host cell. During this process, the neuraminidase of HN proteins aids in separation from the host membrane and prevents virion aggregation.
392:
negative-sense genomic RNA strands are in turn synthesized by RdRp from the antigenome. During this process, the antigenome and newly replicated genomes are encapsidated by the nucleoprotein at the same time as replication. Progeny genomes can be used for additional transcription or replication or may simply be packaged into progeny virions.
575:
exposed to saliva taken from humans in the early stages of the disease developed mumps. Furthermore, they showed that mumps could be transferred to children via filtered and sterilized, bacteria-less preparations of macerated monkey parotid tissue, showing that it was a viral disease. The mumps virus
444:
substitutions per site per year, which is considered to be a very low mutation rate for an RNA virus. Phylogenetic analysis of the entire SH gene indicates that genotypes A and J are related in one branch and split apart from the other genotypes. In that second branch, genotype I is a sister clade of
583:
developed a more effective mumps vaccine using live virus particles that were taken from his then five-year-old infected daughter, Jeryl Lynn. This vaccine was approved for use in 1967 and recommended in 1977, replacing prior vaccines that were less effective. Hilleman would also work to develop the
427:
The different genotypes vary in frequency from region to region. For example, genotypes C, D, H, and J are more common in the western hemisphere, whereas genotypes F, G, and I are more common in Asia, although genotype G is considered to be a global genotype. Genotypes A and B have not been observed
677:
The word "mumps" is first attested circa 1600 and is the plural form of "mump", meaning "grimace", originally a verb meaning "to whine or mutter like a beggar". The disease was likely called mumps in reference to the swelling caused by mumps parotitis, reflecting its impact on facial expressions as
407:
Budding from the host cell begins once M proteins recruit host class E proteins that form endosomal sorting complex required for transport (ESCRT) structures at the site of budding. There, ESCRT proteins form into concentric spirals and push the contents of the virion outward from the cell in the
329:
The SH protein is thought to be involved in blocking NF(α)-mediated apoptosis of the host cell, which is done as an antiviral response to suppress the spread of viruses, though SH is not necessary for replication since MuVs engineered without SH are still able to replicate. The V protein is also
367:
Upon entering the host cell, the RdRp begins transcribing mRNA from the genome inside the RNP. Transcription starts at or near the 3'-end (usually pronounced "three prime end") at a promoter region and moves sequentially toward the 5'-end. One mRNA strand is transcribed for each gene, and it is
403:
to the cell membrane, whether they bind to the cell membrane and protrude from the surface of the cell. M proteins bind to the sites of the cell membrane where HN and F proteins are, doing so at the positions where their "tails" protrude into the inside of the cell membrane in the cytoplasm. M
351:
membrane, which contains two types of spikes on its surface that correspond to the HN and F glycoproteins. M proteins are found on the inner side of the envelope, connecting the envelope to the RNP. Virions vary in size from 100 to 600 nanometers (nm) in diameter and are pleomorphic in shape.
391:
Later in the replication cycle, once a sufficient number of nucleoproteins are present after translation, RdRp switches functions to replicate the genome. This occurs in a two-step process: first, a positive-sense antigenome is synthesized by RdRp from the negative-sense genome, and second,
497:. Mumps is usually not life-threatening and typically resolves within a few weeks after the onset of symptoms, but long-term complications such as paralysis, seizures, hydrocephalus, and deafness can occur. Treatment is supportive in nature, and infection is preventable via vaccination.
291:
The mumps virus contains a nonsegmented, single-stranded, linear genome that is 15,384 nucleotides in length and made of ribonucleic acid (RNA). The genome has negative sense, so mRNA can be transcribed directly from the genome. Mumps virus encodes seven genes in the following order:
42:
232:. MuV particles, called virions, are pleomorphic in shape and vary in size from 100 to 600 nanometers in diameter. One serotype and twelve genotypes that vary in their geographic distribution are recognized. Humans are the only natural host of the mumps virus.
368:
necessary for all genes sequentially before a gene to be transcribed for that gene to be transcribed. Genes closer to the 3'-end are transcribed at the highest frequency, decreasing in frequency as RdRp approaches the 5'-end. RdRp synthesizes a
342:
The genome of the mumps virus is encased by N proteins to form a flexible, loosely coiled helical ribonucleoprotein (RNP) complex consisting of the genome surrounded by a nucleocapsid that RdRp is bound to. RNPs are surrounded by an
541:
Week number.year, the date of onset of when the disease occurred, or the date of specimen collection if the disease onset date is unknown, or the date the sample was received in the laboratory if the two prior dates are
380:. Once a gene has been transcribed, RdRp releases it into the cytoplasm for subsequent translation of viral proteins by host ribosomes. The V and P proteins are encoded by the same gene, so while transcribing mRNA, RdRp
1041:"The VSV polymerase can initiate at mRNA start sites located either up or downstream of a transcription termination signal but size of the intervening intergenic region affects efficiency of initiation"
428:
in the wild since the 1990s. This diversity of MuV is not reflected in the antibody response since because there is only one serotype, antibodies to one genotype are also functional against all others.
853:
404:
proteins then act as a signals to newly synthesized RNPs as to where virions are to be formed. The interaction of RNP and M proteins is then thought to trigger budding from the host cell.
2328:
1290:"Visual tools to assess the plausibility of algorithm-identified infectious disease clusters: an application to mumps data from the Netherlands dating from January 2009 to June 2016"
235:
MuV replicates first by binding to the surface of cells, whereby its envelope merges with the host cell membrane to release the capsid inside of the cell. Once inside, the viral
457:. The disease is transmitted via contact with respiratory secretions such as aerosolized droplets and saliva. Infection leads to fever, muscle pain, and painful swelling of the
465:
situated on the sides of the mouth in front of the ears. Infection may also involve many other tissues and organs, resulting in a variety of inflammatory reactions such as
678:
well as its causing of painful, difficult swallowing. "Mumps" was also used starting from the 17th century to mean "a fit of melancholy, sullenness, silent displeasure".
249:
of viral proteins, virions are formed adjacent to the cell membrane, where they then leave the cell by budding from its surface, using the cell membrane as the envelope.
1751:
2835:
600:
2848:
2794:
2342:
555:
This system is used in sequential order. For example, MuVs/NewYork.USA/17.11 (VAC) is a vaccine-associated genotype B MuV derived from clinical material in
895:
2008:
1839:
1879:
2886:
1448:
Jenkins GM, Rambaut A, Pybus OG, Holmes EC (7 December 2017). "Rates of molecular evolution in RNA viruses: a quantitative phylogenetic analysis".
256:
protecting against MuV infection had been developed. MuV was first recognized as a species in 1971, and it has been given the scientific name
1744:
1972:
1391:
Cui A, Rivailler P, Zhu Z, Deng X, Hu Y, Wang Y, Li F, Sun Z, He J, Si Y, Tian X, Zhou S, Lei Y, Zheng H, Rota PA, Xu W (7 December 2017).
2029:
252:
The mumps virus was first identified as the cause of mumps in 1934 and was first isolated in 1945. Within a few years after isolation,
224:(RNA). Its genome is about 15,000 nucleotides in length and contains seven genes that encode nine proteins. The genome is encased by a
2881:
2348:
1874:
1831:
2263:
2334:
1737:
49:
317:
the large (L) protein, which combines with the P protein to form the RNA-dependent RNA polymerase (RdRp). RdRp acts as both a
1933:
1919:
62:
1119:"The P gene of the porcine paramyxovirus LPMV encodes three possible polypeptides P, V and C: the P protein mRNA is edited"
596:. The "Jeryl Lynn" strain of the mumps virus, which belongs to genotype A, continues to be used in vaccines against mumps.
551:(VAC), which is used to indicate strains derived from cases with a history of vaccination and with vaccine virus detected
2138:
2132:
2043:
2037:
1927:
236:
579:
Initial vaccines contained inactivated virus particles and provided short-term protection against mumps. In the 1960s,
2501:
2427:
2421:
2094:
930:"Paramyxovirus glycoprotein incorporation, assembly and budding: a three way dance for infectious particle production"
571:
In 1934, mumps was identified as a viral disease by Claude D. Johnson and Ernest
William Goodpasture. They found that
311:
2799:
1648:
2853:
1163:"Mumps virus matrix, fusion, and nucleocapsid proteins cooperate for efficient production of virus-like particles"
2558:
2165:
217:
445:
the other genotypes, which cluster into five sequential sister clades: G and H; D and K; C; L; and B, F, and N.
2267:
2179:
2084:
1914:
1887:
1859:
1792:
2063:
1674:
Buschmann AB, Dundon WG, Easton AJ, Fouchier RA, Kurath G, Lamb RA, Rima BK, Rota PA, Wang L (6 June 2018).
239:
2257:
1853:
2896:
2876:
2747:
2457:
2435:
2314:
2310:
2306:
2302:
2195:
2089:
2050:
2785:
2442:
2023:
1893:
1675:
396:
246:
1864:
511:
262:
159:
2706:
2538:
2173:
2002:
1404:
57:
2124:
1845:
849:
747:
322:
2227:
1983:
1525:
1473:
700:
330:
involved in evading host antiviral responses by means of inhibiting production and signalling of
182:
1729:
576:
was isolated for the first time in 1945 and by 1948 the first mumps vaccine had been developed.
2840:
1393:"Evolutionary analysis of mumps viruses of genotype F collected in mainland China in 2001-2015"
2691:
2642:
2623:
2604:
2394:
2390:
2386:
2382:
2299:
2204:
1908:
1786:
1625:
1576:
1517:
1465:
1430:
1373:
1319:
1260:
1192:
1140:
1070:
1021:
961:
887:
830:
781:
607:. Since then, it has undergone numerous taxonomic changes and changes to its scientific name:
360:
MuV first interacts with a host cell by binding to its surface via the HN protein's receptor,
2666:
2376:
2056:
1988:
1869:
1800:
1615:
1607:
1566:
1556:
1507:
1457:
1420:
1412:
1363:
1353:
1309:
1305:
1301:
1182:
1174:
1130:
1060:
1052:
1011:
1003:
951:
941:
877:
869:
820:
812:
771:
763:
580:
437:
221:
1707:
1210:
2590:
2518:
2513:
2495:
2415:
2404:
2275:
2239:
2159:
1945:
1806:
523:
373:
274:
147:
135:
111:
1408:
2891:
1826:
1620:
1595:
1571:
1544:
1425:
1392:
1368:
1341:
1314:
1289:
1187:
1162:
1065:
1040:
1016:
991:
956:
929:
882:
825:
800:
776:
751:
572:
462:
369:
344:
229:
123:
531:
MuVs (RNA sequence derived from clinical material) or MuVi (RNA sequence derived from
2870:
1821:
1816:
1764:
1512:
1495:
556:
517:
458:
400:
268:
242:
99:
1529:
1494:
Davis NF, McGuire BB, Mahon JA, Smyth AE, O'Malley KJ, Fitzpatrick JM (April 2010).
1477:
2682:
2532:
2210:
2071:
616:
532:
482:
466:
1611:
2770:
1561:
1288:
Soetenes L, Backer JA, Hahne S, Binnendijk RV, Gouma S, Wallinga J (March 2019).
1007:
992:"Paramyxovirus assembly and budding: building particles that transmit infections"
852:, Easton A, Fouchier R, Kurath G, Lamb R, Lee B, Rota P, Wang L (December 2019).
816:
17:
2779:
2671:
2659:
2654:
2647:
2635:
2630:
2609:
2579:
2320:
2232:
2215:
2150:
1811:
1342:"Mumps in the Vaccination Age: Global Epidemiology and the Situation in Germany"
1245:
1135:
1118:
1056:
585:
478:
436:
The F, SH, HN genes, used to distinguish genotypes, are estimated to experience
381:
361:
2826:
1416:
2572:
2356:
2113:
1461:
559:, and MuVi/London.GBR/3.12/2 is a genotype G MuV derived from cell culture in
490:
470:
331:
2617:
2598:
2565:
2553:
2547:
2526:
2472:
2400:
2371:
2294:
2286:
2248:
2017:
1996:
1902:
1780:
1772:
1760:
486:
318:
87:
1629:
1580:
1521:
1469:
1434:
1377:
1358:
1323:
1264:
1196:
1074:
1025:
965:
891:
834:
785:
1144:
2820:
2764:
2715:
2362:
2104:
1960:
1178:
873:
603:(ICTV), which oversees virus taxonomy, when it was assigned to the genus
494:
474:
421:
417:
41:
2468:
593:
589:
385:
377:
253:
767:
527:. Strains of MuV are named and classified using the following system:
2077:
946:
560:
225:
2741:
1496:"The increasing incidence of mumps orchitis: a comprehensive review"
1091:
2728:
2487:
2119:
1161:
Li M, Schmitt PT, Li Z, McCrory TS, He B, Schmitt AP (July 2009).
454:
453:
Humans are the only natural host of the mumps virus, which causes
348:
334:. Unlike the other proteins, the I protein's function is unknown.
213:
209:
74:
1596:"Knowledge gaps persist and hinder progress in eliminating mumps"
2745:
1733:
1954:
1594:
Ramanathan R, Voigt EA, Kennedy RB, Poland GA (18 June 2018).
752:"Molecular biology, pathogenesis and pathology of mumps virus"
245:(mRNA) from the genome and later replicates the genome. After
1039:
Barr JN, Tang X, Hinzman E, Shen R, Wertz GW (10 May 2008).
660:
In 2020, type species in virus taxonomy were abolished, so
302:
matrix (M) protein, the most abundant protein in virions,
1117:
Berg M, Hjertner B, Moreno-Lopez J, Linne T (May 1992).
990:
Harrison MS, Sakaguchi T, Schmitt AP (September 2010).
801:"Structure and organization of paramyxovirus particles"
599:
Mumps virus was recognized as a species in 1971 by the
653:
bearing the same name and the newly established genus
548:, which indicates which genotype the strain belongs to
388:
into the mRNA to transcribes mRNA for the P protein.
376:
on the 3'-end consisting of hundreds of consecutive
2810:
2754:
2705:
2681:
2589:
2512:
2467:
2456:
2285:
2247:
2226:
2194:
2149:
2103:
1982:
1971:
1944:
1771:
928:Najjar FE, Schmitt AP, Dutch RE (7 August 2014).
649:being abolished and replaced with the subfamily
1687:International Committee on Taxonomy of Viruses
709:International Committee on Taxonomy of Viruses
601:International Committee on Taxonomy of Viruses
1745:
308:small hydrophobic (SH) transmembrane protein,
8:
1211:"Viral budding via the host ESCRT complexes"
746:Rubin S, Eckhaus M, Rennick LJ, Bamford CG,
1655:. Pharamaceutical Technology. 25 April 2018
1283:
1281:
2742:
2464:
2244:
2009:Progressive multifocal leukoencephalopathy
1979:
1752:
1738:
1730:
1643:
1641:
1639:
985:
983:
981:
979:
977:
975:
40:
29:
1880:Extranodal NK/T-cell lymphoma, nasal type
1619:
1570:
1560:
1511:
1424:
1367:
1357:
1335:
1333:
1313:
1186:
1134:
1064:
1015:
955:
945:
881:
824:
775:
395:HN and F proteins are synthesized in the
1649:"Tracing the story of mumps: a timeline"
1489:
1487:
923:
921:
919:
917:
915:
913:
384:the mRNA by inserting two non-templated
1306:10.2807/1560-7917.ES.2019.24.12.1800331
1246:"Mumps virus nomenclature update: 2012"
741:
739:
737:
735:
733:
731:
729:
727:
725:
687:
1340:Beleni AI, Borgmann S (31 July 2018).
1240:
1238:
1236:
1234:
1232:
1086:
1084:
695:
693:
691:
1156:
1154:
52:micrograph of a mumps virus particle
7:
1543:Latner DR, Hickman CJ (7 May 2015).
2030:Subacute sclerosing panencephalitis
1217:. Swiss Institute of Bioinformatics
1098:. Swiss Institute of Bioinformatics
664:was removed as the type species of
325:to transcribe mRNA from the genome.
216:. MuV contains a single-stranded,
25:
2349:Severe acute respiratory syndrome
1875:Follicular dendritic cell sarcoma
848:Rima B, Buschmann AB, Dundon WG,
321:to replicate the genome and as a
299:V/P/I (V/phospho-(P)/I) proteins,
2335:Middle East respiratory syndrome
1513:10.1111/j.1464-410X.2009.09148.x
799:Cox RM, Plemper RK (June 2017).
228:that is in turn surrounded by a
61:
2887:Human viruses described in 1934
1676:"Re-organization of the family
1346:Int J Environ Res Public Health
619:of the newly established genus
1934:Adult T-cell leukemia/lymphoma
1920:Splenic marginal zone lymphoma
854:"ICTV Virus Taxonomy Profile:
260:. It is assigned to the genus
1:
1714:. Online Etymology Dictionary
1612:10.1016/j.vaccine.2018.05.067
505:Mumps virus, scientific name
27:Viral agent that causes mumps
2139:Tropical spastic paraparesis
2044:Lymphocytic choriomeningitis
1562:10.1371/journal.ppat.1004791
1259:(22): 217–224. 1 June 2012.
1008:10.1016/j.biocel.2010.04.005
817:10.1016/j.coviro.2017.05.004
237:RNA-dependent RNA polymerase
2502:Cytomegalovirus esophagitis
2422:Human parainfluenza viruses
2095:Ramsay Hunt syndrome type 2
1136:10.1099/0022-1317-73-5-1195
1057:10.1016/j.virol.2007.12.023
588:in 1971, effective against
509:, is assigned to the genus
312:hemagglutinin-neuraminidase
2913:
1417:10.1038/s41598-017-17474-z
2882:Viruses described in 1934
2166:Cytomegalovirus retinitis
1653:Pharmaceutical Technology
1462:10.1007/s00239-001-0064-3
296:nucleocapsid (N) protein,
188:
181:
56:
48:
39:
32:
2268:Infectious mononucleosis
2085:Chandipura vesiculovirus
1915:Hepatocellular carcinoma
1860:Nasopharyngeal carcinoma
1793:Hepatocellular carcinoma
701:"ICTV Taxonomy history:
416:The mumps virus has one
2064:Encephalitis lethargica
1765:viral systemic diseases
996:Int J Biochem Cell Biol
615:was established as the
399:and travel through the
2436:Human orthopneumovirus
2090:Herpesviral meningitis
2051:Arbovirus encephalitis
1359:10.3390/ijerph15081618
703:Mumps orthorubulavirus
662:Mumps orthorubulavirus
643:Mumps orthorubulavirus
538:City.Country ISO3 code
507:Mumps orthorubulavirus
258:Mumps orthorubulavirus
174:Mumps orthorubulavirus
34:Mumps orthorubulavirus
1894:Merkel-cell carcinoma
397:endoplasmic reticulum
2539:Adenovirus infection
2003:Human polyomavirus 2
1832:Oropharyngeal cancer
1179:10.1128/JVI.00421-09
898:on February 27, 2020
874:10.1099/jgv.0.001328
58:Virus classification
2125:Post-polio syndrome
1761:Infectious diseases
1545:"Remembering mumps"
1409:2017NatSR...717144C
515:, in the subfamily
374:polyadenylated tail
305:fusion (F) protein,
2258:Epstein–Barr virus
2228:Respiratory system
1865:Burkitt's lymphoma
1253:Wkly Epidemiol Rec
372:of the mRNA and a
2864:
2863:
2786:Mumps rubulavirus
2756:Mumps rubulavirus
2748:Taxon identifiers
2739:
2738:
2701:
2700:
2452:
2451:
2383:Influenza virus A
2300:Human coronavirus
2190:
2189:
2180:Herpes of the eye
1606:(26): 3721–3726.
1173:(14): 7261–7272.
1092:"Paramyxoviridae"
868:(12): 1593–1954.
768:10.1002/path.4445
639:Mumps rubulavirus
632:Mumps rubulavirus
545:replicate in week
438:genetic mutations
370:cap on the 5'-end
266:in the subfamily
202:
201:
192:Mumps rubulavirus
18:Mumps rubulavirus
16:(Redirected from
2904:
2857:
2856:
2844:
2843:
2831:
2830:
2829:
2803:
2802:
2790:
2789:
2788:
2775:
2774:
2773:
2743:
2465:
2460:digestive system
2377:Orthomyxoviridae
2343:SARS coronavirus
2329:MERS coronavirus
2245:
2057:Orthomyxoviridae
1980:
1946:Immune disorders
1870:Hodgkin lymphoma
1846:Kaposi's sarcoma
1754:
1747:
1740:
1731:
1724:
1723:
1721:
1719:
1704:
1698:
1697:
1695:
1693:
1684:
1671:
1665:
1664:
1662:
1660:
1645:
1634:
1633:
1623:
1591:
1585:
1584:
1574:
1564:
1540:
1534:
1533:
1515:
1506:(8): 1060–1065.
1491:
1482:
1481:
1445:
1439:
1438:
1428:
1388:
1382:
1381:
1371:
1361:
1337:
1328:
1327:
1317:
1285:
1276:
1275:
1273:
1271:
1250:
1242:
1227:
1226:
1224:
1222:
1207:
1201:
1200:
1190:
1158:
1149:
1148:
1138:
1129:(5): 1195–1200.
1114:
1108:
1107:
1105:
1103:
1088:
1079:
1078:
1068:
1036:
1030:
1029:
1019:
1002:(9): 1416–1429.
987:
970:
969:
959:
949:
947:10.3390/v6083019
940:(8): 3019–3054.
925:
908:
907:
905:
903:
894:. Archived from
885:
845:
839:
838:
828:
796:
790:
789:
779:
750:(January 2015).
743:
720:
719:
717:
715:
697:
666:Orthorubulavirus
655:Orthorubulavirus
581:Maurice Hilleman
512:Orthorubulavirus
443:
263:Orthorubulavirus
222:ribonucleic acid
161:Orthorubulavirus
66:
65:
44:
30:
21:
2912:
2911:
2907:
2906:
2905:
2903:
2902:
2901:
2867:
2866:
2865:
2860:
2852:
2847:
2839:
2834:
2825:
2824:
2819:
2806:
2798:
2793:
2784:
2783:
2778:
2769:
2768:
2763:
2750:
2740:
2735:
2697:
2677:
2585:
2559:Gastroenteritis
2517:
2514:Gastroenteritis
2508:
2496:Cytomegalovirus
2459:
2448:
2416:Paramyxoviridae
2405:Avian influenza
2281:
2276:Cytomegalovirus
2240:viral pneumonia
2238:
2235:nasopharyngitis
2234:
2231:
2222:
2186:
2160:Cytomegalovirus
2145:
2099:
1987:
1974:
1967:
1940:
1807:Cervical cancer
1767:
1758:
1728:
1727:
1717:
1715:
1706:
1705:
1701:
1691:
1689:
1682:
1678:Paramyxoviridae
1673:
1672:
1668:
1658:
1656:
1647:
1646:
1637:
1593:
1592:
1588:
1555:(5): e1004791.
1542:
1541:
1537:
1493:
1492:
1485:
1447:
1446:
1442:
1390:
1389:
1385:
1339:
1338:
1331:
1300:(12): 1800331.
1287:
1286:
1279:
1269:
1267:
1248:
1244:
1243:
1230:
1220:
1218:
1209:
1208:
1204:
1160:
1159:
1152:
1116:
1115:
1111:
1101:
1099:
1090:
1089:
1082:
1038:
1037:
1033:
989:
988:
973:
927:
926:
911:
901:
899:
856:Paramyxoviridae
847:
846:
842:
805:Curr Opin Virol
798:
797:
793:
745:
744:
723:
713:
711:
699:
698:
689:
684:
675:
641:was renamed to
630:was renamed to
573:rhesus macaques
569:
524:Paramyxoviridae
503:
463:salivary glands
451:
441:
434:
414:
358:
340:
289:
284:
282:Characteristics
275:Paramyxoviridae
220:genome made of
177:
149:Paramyxoviridae
137:Mononegavirales
113:Negarnaviricota
60:
28:
23:
22:
15:
12:
11:
5:
2910:
2908:
2900:
2899:
2894:
2889:
2884:
2879:
2869:
2868:
2862:
2861:
2859:
2858:
2845:
2832:
2816:
2814:
2808:
2807:
2805:
2804:
2791:
2776:
2760:
2758:
2752:
2751:
2746:
2737:
2736:
2734:
2733:
2732:
2731:
2719:
2711:
2709:
2703:
2702:
2699:
2698:
2696:
2695:
2687:
2685:
2679:
2678:
2676:
2675:
2663:
2651:
2639:
2627:
2620:
2614:
2613:
2601:
2595:
2593:
2587:
2586:
2584:
2583:
2576:
2569:
2562:
2550:
2544:
2543:
2542:
2541:
2529:
2523:
2521:
2510:
2509:
2507:
2506:
2505:
2504:
2492:
2491:
2490:
2477:
2475:
2462:
2454:
2453:
2450:
2449:
2447:
2446:
2439:
2432:
2431:
2430:
2410:
2409:
2408:
2407:
2368:
2367:
2366:
2365:
2353:
2352:
2351:
2339:
2338:
2337:
2325:
2324:
2323:
2291:
2289:
2283:
2282:
2280:
2279:
2272:
2271:
2270:
2253:
2251:
2242:
2224:
2223:
2221:
2220:
2219:
2218:
2213:
2200:
2198:
2196:Cardiovascular
2192:
2191:
2188:
2187:
2185:
2184:
2183:
2182:
2170:
2169:
2168:
2155:
2153:
2147:
2146:
2144:
2143:
2142:
2141:
2129:
2128:
2127:
2122:
2109:
2107:
2101:
2100:
2098:
2097:
2092:
2087:
2082:
2081:
2080:
2068:
2067:
2066:
2053:
2048:
2047:
2046:
2034:
2033:
2032:
2020:
2014:
2013:
2012:
2011:
1999:
1993:
1991:
1977:
1975:nervous system
1969:
1968:
1966:
1965:
1964:
1963:
1950:
1948:
1942:
1941:
1939:
1938:
1937:
1936:
1924:
1923:
1922:
1917:
1905:
1899:
1898:
1897:
1896:
1884:
1883:
1882:
1877:
1872:
1867:
1862:
1850:
1849:
1848:
1836:
1835:
1834:
1829:
1827:Vaginal cancer
1824:
1819:
1814:
1809:
1797:
1796:
1795:
1783:
1777:
1775:
1769:
1768:
1759:
1757:
1756:
1749:
1742:
1734:
1726:
1725:
1699:
1666:
1635:
1586:
1535:
1483:
1456:(2): 156–165.
1440:
1383:
1329:
1277:
1228:
1202:
1150:
1109:
1080:
1051:(2): 261–270.
1031:
971:
909:
840:
791:
762:(2): 242–252.
721:
686:
685:
683:
680:
674:
671:
670:
669:
658:
635:
624:
568:
565:
553:
552:
549:
546:
543:
539:
536:
502:
501:Classification
499:
459:parotid glands
450:
447:
433:
430:
413:
410:
357:
354:
339:
336:
327:
326:
315:
309:
306:
303:
300:
297:
288:
285:
283:
280:
230:viral envelope
218:negative-sense
200:
199:
198:
197:
194:
186:
185:
179:
178:
171:
169:
165:
164:
157:
153:
152:
145:
141:
140:
133:
129:
128:
125:Monjiviricetes
121:
117:
116:
109:
105:
104:
97:
93:
92:
85:
78:
77:
72:
68:
67:
54:
53:
46:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2909:
2898:
2897:Rubulaviruses
2895:
2893:
2890:
2888:
2885:
2883:
2880:
2878:
2877:Human viruses
2875:
2874:
2872:
2855:
2850:
2846:
2842:
2837:
2833:
2828:
2822:
2818:
2817:
2815:
2813:
2809:
2801:
2796:
2792:
2787:
2781:
2777:
2772:
2766:
2762:
2761:
2759:
2757:
2753:
2749:
2744:
2730:
2727:
2726:
2725:
2724:
2720:
2718:
2717:
2713:
2712:
2710:
2708:
2704:
2694:
2693:
2689:
2688:
2686:
2684:
2680:
2673:
2669:
2668:
2664:
2661:
2657:
2656:
2652:
2649:
2645:
2644:
2640:
2637:
2633:
2632:
2628:
2626:
2625:
2621:
2619:
2616:
2615:
2611:
2607:
2606:
2602:
2600:
2597:
2596:
2594:
2592:
2588:
2582:
2581:
2577:
2575:
2574:
2570:
2568:
2567:
2563:
2560:
2556:
2555:
2551:
2549:
2546:
2545:
2540:
2537:
2536:
2535:
2534:
2530:
2528:
2525:
2524:
2522:
2520:
2515:
2511:
2503:
2500:
2499:
2498:
2497:
2493:
2489:
2486:
2485:
2484:
2483:
2479:
2478:
2476:
2474:
2470:
2466:
2463:
2461:
2455:
2445:
2444:
2440:
2438:
2437:
2433:
2429:
2428:Parainfluenza
2426:
2425:
2424:
2423:
2418:
2417:
2412:
2411:
2406:
2402:
2399:
2398:
2397:
2396:
2392:
2388:
2384:
2379:
2378:
2373:
2370:
2369:
2364:
2361:
2360:
2359:
2358:
2354:
2350:
2347:
2346:
2345:
2344:
2340:
2336:
2333:
2332:
2331:
2330:
2326:
2322:
2319:
2318:
2317:
2316:
2312:
2308:
2304:
2301:
2296:
2293:
2292:
2290:
2288:
2284:
2278:
2277:
2273:
2269:
2265:
2264:EBV infection
2262:
2261:
2260:
2259:
2255:
2254:
2252:
2250:
2246:
2243:
2241:
2236:
2229:
2225:
2217:
2214:
2212:
2209:
2208:
2207:
2206:
2202:
2201:
2199:
2197:
2193:
2181:
2178:
2177:
2176:
2175:
2171:
2167:
2164:
2163:
2162:
2161:
2157:
2156:
2154:
2152:
2148:
2140:
2137:
2136:
2135:
2134:
2130:
2126:
2123:
2121:
2120:Poliomyelitis
2118:
2117:
2116:
2115:
2111:
2110:
2108:
2106:
2102:
2096:
2093:
2091:
2088:
2086:
2083:
2079:
2076:
2075:
2074:
2073:
2069:
2065:
2062:
2061:
2059:
2058:
2054:
2052:
2049:
2045:
2042:
2041:
2040:
2039:
2035:
2031:
2028:
2027:
2026:
2025:
2021:
2019:
2016:
2015:
2010:
2007:
2006:
2005:
2004:
2000:
1998:
1995:
1994:
1992:
1990:
1985:
1981:
1978:
1976:
1970:
1962:
1959:
1958:
1957:
1956:
1952:
1951:
1949:
1947:
1943:
1935:
1932:
1931:
1930:
1929:
1925:
1921:
1918:
1916:
1913:
1912:
1911:
1910:
1906:
1904:
1901:
1900:
1895:
1892:
1891:
1890:
1889:
1885:
1881:
1878:
1876:
1873:
1871:
1868:
1866:
1863:
1861:
1858:
1857:
1856:
1855:
1851:
1847:
1844:
1843:
1842:
1841:
1837:
1833:
1830:
1828:
1825:
1823:
1822:Vulvar cancer
1820:
1818:
1817:Penile cancer
1815:
1813:
1810:
1808:
1805:
1804:
1803:
1802:
1798:
1794:
1791:
1790:
1789:
1788:
1784:
1782:
1779:
1778:
1776:
1774:
1770:
1766:
1762:
1755:
1750:
1748:
1743:
1741:
1736:
1735:
1732:
1713:
1709:
1703:
1700:
1688:
1681:
1679:
1670:
1667:
1654:
1650:
1644:
1642:
1640:
1636:
1631:
1627:
1622:
1617:
1613:
1609:
1605:
1601:
1597:
1590:
1587:
1582:
1578:
1573:
1568:
1563:
1558:
1554:
1550:
1546:
1539:
1536:
1531:
1527:
1523:
1519:
1514:
1509:
1505:
1501:
1497:
1490:
1488:
1484:
1479:
1475:
1471:
1467:
1463:
1459:
1455:
1451:
1444:
1441:
1436:
1432:
1427:
1422:
1418:
1414:
1410:
1406:
1402:
1398:
1394:
1387:
1384:
1379:
1375:
1370:
1365:
1360:
1355:
1351:
1347:
1343:
1336:
1334:
1330:
1325:
1321:
1316:
1311:
1307:
1303:
1299:
1295:
1294:Euro Surveill
1291:
1284:
1282:
1278:
1266:
1262:
1258:
1254:
1247:
1241:
1239:
1237:
1235:
1233:
1229:
1216:
1212:
1206:
1203:
1198:
1194:
1189:
1184:
1180:
1176:
1172:
1168:
1164:
1157:
1155:
1151:
1146:
1142:
1137:
1132:
1128:
1124:
1120:
1113:
1110:
1097:
1093:
1087:
1085:
1081:
1076:
1072:
1067:
1062:
1058:
1054:
1050:
1046:
1042:
1035:
1032:
1027:
1023:
1018:
1013:
1009:
1005:
1001:
997:
993:
986:
984:
982:
980:
978:
976:
972:
967:
963:
958:
953:
948:
943:
939:
935:
931:
924:
922:
920:
918:
916:
914:
910:
897:
893:
889:
884:
879:
875:
871:
867:
863:
859:
857:
851:
844:
841:
836:
832:
827:
822:
818:
814:
810:
806:
802:
795:
792:
787:
783:
778:
773:
769:
765:
761:
757:
753:
749:
742:
740:
738:
736:
734:
732:
730:
728:
726:
722:
710:
706:
704:
696:
694:
692:
688:
681:
679:
672:
667:
663:
659:
656:
652:
651:Rubulavirinae
648:
645:to accompany
644:
640:
636:
633:
629:
625:
622:
618:
614:
610:
609:
608:
606:
605:Paramyxovirus
602:
597:
595:
592:, mumps, and
591:
587:
582:
577:
574:
566:
564:
562:
558:
557:New York City
550:
547:
544:
540:
537:
534:
530:
529:
528:
526:
525:
520:
519:
518:Rubulavirinae
514:
513:
508:
500:
498:
496:
492:
488:
484:
480:
476:
472:
468:
464:
460:
456:
448:
446:
440:at a rate of
439:
431:
429:
425:
423:
419:
411:
409:
405:
402:
401:Golgi complex
398:
393:
389:
387:
383:
379:
375:
371:
365:
363:
355:
353:
350:
346:
337:
335:
333:
324:
323:transcriptase
320:
316:
313:
310:
307:
304:
301:
298:
295:
294:
293:
286:
281:
279:
277:
276:
271:
270:
269:Rubulavirinae
265:
264:
259:
255:
250:
248:
244:
243:messenger RNA
241:
238:
233:
231:
227:
223:
219:
215:
211:
208:(MuV) is the
207:
195:
193:
190:
189:
187:
184:
180:
176:
175:
170:
167:
166:
163:
162:
158:
155:
154:
151:
150:
146:
143:
142:
139:
138:
134:
131:
130:
127:
126:
122:
119:
118:
115:
114:
110:
107:
106:
103:
102:
101:Orthornavirae
98:
95:
94:
91:
90:
86:
83:
80:
79:
76:
73:
70:
69:
64:
59:
55:
51:
47:
43:
38:
35:
31:
19:
2811:
2755:
2722:
2721:
2714:
2690:
2683:Pancreatitis
2665:
2653:
2641:
2629:
2622:
2603:
2578:
2571:
2564:
2552:
2531:
2494:
2481:
2480:
2441:
2434:
2420:
2414:
2381:
2375:
2355:
2341:
2327:
2298:
2274:
2256:
2211:Pericarditis
2203:
2172:
2158:
2131:
2112:
2070:
2055:
2036:
2022:
2001:
1984:Encephalitis
1953:
1926:
1907:
1886:
1852:
1838:
1799:
1785:
1716:. Retrieved
1711:
1708:"mumps (n.)"
1702:
1690:. Retrieved
1686:
1677:
1669:
1657:. Retrieved
1652:
1603:
1599:
1589:
1552:
1548:
1538:
1503:
1499:
1453:
1449:
1443:
1403:(1): 17144.
1400:
1396:
1386:
1349:
1345:
1297:
1293:
1268:. Retrieved
1256:
1252:
1219:. Retrieved
1214:
1205:
1170:
1166:
1126:
1122:
1112:
1100:. Retrieved
1095:
1048:
1044:
1034:
999:
995:
937:
933:
900:. Retrieved
896:the original
865:
861:
855:
843:
808:
804:
794:
759:
755:
712:. Retrieved
708:
702:
676:
665:
661:
654:
650:
646:
642:
638:
631:
627:
620:
617:type species
612:
604:
598:
578:
570:
554:
533:cell culture
522:
516:
510:
506:
504:
483:pancreatitis
467:encephalitis
452:
435:
426:
415:
406:
394:
390:
366:
359:
341:
328:
290:
273:
267:
261:
257:
251:
234:
212:that causes
205:
203:
191:
173:
172:
160:
148:
136:
124:
112:
100:
88:
81:
71:(unranked):
33:
2812:Mumps virus
2780:Wikispecies
2580:Coronavirus
2321:Common cold
2233:acute viral
2216:Myocarditis
2060:(probable)
1812:Anal cancer
1549:PLOS Pathog
1352:(8): 1618.
1123:J Gen Virol
862:J Gen Virol
811:: 105–114.
647:Rubulavirus
628:Mumps virus
621:Rubulavirus
613:Mumps virus
586:MMR vaccine
479:myocarditis
420:and twelve
362:sialic acid
332:interferons
247:translation
240:transcribes
206:mumps virus
196:Mumps virus
2871:Categories
2707:Urogenital
2573:Astrovirus
2533:Adenovirus
2357:SARS-CoV-2
2114:Poliovirus
1989:meningitis
1712:Etymonline
1450:J Mol Evol
682:References
491:oophoritis
471:meningitis
469:, aseptic
356:Life cycle
2771:Q29004679
2618:RNA virus
2599:DNA virus
2591:Hepatitis
2566:Norovirus
2554:Rotavirus
2548:RNA virus
2527:DNA virus
2473:Esophagus
2401:Influenza
2287:RNA virus
2249:DNA virus
2018:RNA virus
1997:DNA virus
1903:RNA virus
1781:DNA virus
1773:Oncovirus
1718:21 August
1692:21 August
1659:21 August
1270:21 August
1221:21 August
1215:ViralZone
1102:21 August
1096:ViralZone
902:21 August
850:Duprex WP
748:Duprex WP
673:Etymology
637:In 2018,
626:In 2016,
611:In 1995,
521:, family
487:nephritis
442:0.25 · 10
432:Evolution
422:genotypes
412:Diversity
338:Structure
319:replicase
314:(HN), and
272:, family
168:Species:
96:Kingdom:
89:Riboviria
2841:11460301
2827:Q1952649
2821:Wikidata
2765:Wikidata
2716:BK virus
2519:diarrhea
2363:COVID-19
2105:Myelitis
1630:29784466
1581:25951183
1530:20761646
1522:20070300
1478:20759532
1470:11821909
1435:29215070
1378:30065192
1324:30914076
1265:24340404
1197:19439476
1075:18241907
1045:Virology
1026:20398786
966:25105277
892:31609197
835:28601688
786:25229387
756:J Pathol
495:mastitis
475:orchitis
418:serotype
386:guanines
378:adenines
345:envelope
254:vaccines
183:Synonyms
144:Family:
108:Phylum:
2800:1979165
2469:Pharynx
1973:Central
1621:6031229
1600:Vaccine
1572:4423963
1500:BJU Int
1426:5719434
1405:Bibcode
1397:Sci Rep
1369:6121553
1315:6440581
1188:2704775
1167:J Virol
1145:1588322
1066:2593140
1017:2910131
957:4147685
934:Viruses
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826:5529233
777:4268314
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590:measles
567:History
542:unknown
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1928:HTLV-I
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2729:Mumps
2488:Mumps
2458:Human
1888:MCPyV
1526:S2CID
1474:S2CID
1249:(PDF)
455:mumps
382:edits
349:lipid
214:mumps
210:virus
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75:Virus
2849:NCBI
2795:NCBI
2443:hMPV
2315:OC43
2311:HKU1
2307:NL63
2303:229E
1961:AIDS
1840:KSHV
1720:2020
1694:2020
1661:2020
1626:PMID
1577:PMID
1518:PMID
1466:PMID
1431:PMID
1374:PMID
1320:PMID
1272:2020
1261:PMID
1223:2020
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888:PMID
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2605:HBV
2482:MuV
2413:V,
2205:CBV
2174:HSV
2151:Eye
2038:LCV
2024:MeV
1955:HIV
1909:HCV
1854:EBV
1801:HPV
1787:HBV
1616:PMC
1608:doi
1567:PMC
1557:doi
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