108:
59:. Detection of specific autoantibodies (antibodies directed against the body’s own tissue) such as rheumatoid factors and ACPAs may provide indication of the disease. In many cases, autoimmune diagnostics are crucial for diagnosing RA correctly and already in the disease’s early stages, when typical symptoms often are lacking but when medical therapy is most effective.
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for estimating progress of rheumatoid arthritis. Main advantage of testing for anti-MCV is the early appearance of the anti-MCV antibodies, what allows for detection of early RA and submits adequate therapy just after the disease’s onset. Moreover, anti-MCV titres show strong correlation to disease
307:
Bang, Holger; Egerer, Karl; Gauliard, Anke; Lüthke, Kirsten; Rudolph, Paul E.; Fredenhagen, Gert; Berg, Wigbert; Feist, Eugen; Burmester, Gerd-R. (2007). "Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis".
398:"Antibodies against citrullinated vimentin in rheumatoid arthritis: Higher sensitivity and extended prognostic value concerning future radiographic progression as compared with antibodies against cyclic citrullinated peptides"
126:(POCT) for the early detection of RA has been developed. This assay combines the detection of rheumatoid factor and anti-MCV for diagnosis of rheumatoid arthritis and shows a sensitivity of 72% and specificity of 99.7%.
118:
In rheumatology diagnostics, autoantibodies against mutated citrullinated vimentin (anti-MCV) are of prominent diagnostic and prognostic value. Their significance is greater than that of rheumatoid factor.
270:"Does anti-mutated citrullinated vimentin have additional value as a serological marker in the diagnostic and prognostic investigation of patients with rheumatoid arthritis? A systematic review"
92:
Various kinds of citrullinated proteins have been detected in the joints of RA patients. One of these is Sa antigen, now known as mutated citrullinated vimentin (MCV).
343:
Roland, Pascale; Mignot, Sabine; Bruns, Alessandra; Hurtado, Margarita; Palazzo, Elisabeth; Hayem, Gilles; Dieudé, Philippe; Meyer, Olivier; Martin, Sylvie (2008).
151:
György, Bence; Tóth, Erzsébet; Tarcsa, Edit; Falus, András; Buzás, Edit I. (2006). "Citrullination: A posttranslational modification in health and disease".
345:"Antibodies to mutated citrullinated vimentin for diagnosing rheumatoid arthritis in anti-CCP-negative patients and for monitoring infliximab therapy"
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Després, N; Boire, G; Lopez-Longo, FJ; Ménard, HA (1994). "The Sa system: A novel antigen-antibody system specific for rheumatoid arthritis".
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Mathsson, Linda; Mullazehi, Mohammed; Wick, Marius C.; Sjöberg, Olof; Van
Vollenhoven, Ronald; Klareskog, Lars; Rönnelid, Johan (2008).
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89:. The modified (citrullinated) protein may be identified by as foreign, provoking an autoimmune inflammation response.
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240:"Anti-MCV Antibody Test for the Diagnosis of Rheumatoid Arthritis Using a POCT-Immunoassay"
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Renger F, Bang H, Fredenhagen G, Natusch A, Backhaus M, Feist E, Egerer K, Burmester GR.
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American
College of Rheumatology, 2008 Annual Scientific Meeting, Poster Presentation
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32:(RF negative sera). Anti-MCV antibodies are a member of the
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Luime, J J; Colin, E M; Hazes, J M W; Lubberts, E (2009).
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for rheumatoid arthritis using the rheumachec rapid test
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activity, disease severity and the success of therapy.
28:(RA) diagnostics, especially in sera negative for
8:
216:. Exagen Diagnostics. 2010. Archived from
99:plays a decisive role in RA pathogenesis.
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70:is a modification of proteins where a
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14:
36:family, a group of the so-called
350:Arthritis Research & Therapy
274:Annals of the Rheumatic Diseases
129:Anti-MCV are used as efficient
22:mutated citrullinated vimentin
1:
165:10.1016/j.biocel.2006.03.008
188:The Journal of Rheumatology
55:Rheumatoid arthritis is an
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402:Arthritis & Rheumatism
310:Arthritis & Rheumatism
286:10.1136/ard.2008.103283
122:Recently a serological
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112:point-of-care testing
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85:, converting it into
81:is replaced with an
26:rheumatoid arthritis
57:autoimmune disorder
124:point-of-care test
116:
95:Citrullination of
415:10.1002/art.23188
322:10.1002/art.22817
30:rheumatoid factor
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159:(10): 1662–77.
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48:rotein/peptide
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364:10.1186/ar2570
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316:(8): 2503–11.
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194:(6): 1027–33.
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68:Citrullination
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18:autoantibodies
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280:(2): 337–44.
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16:Detection of
408:(1): 36–45.
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252:. Retrieved
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103:Significance
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357:(6): R142.
214:"Avise MCV"
24:is part of
254:2012-11-20
224:2012-11-20
138:References
131:biomarkers
87:citrulline
76:amino acid
444:Arthritis
52:ntigens.
438:Category
424:18163519
383:19077182
330:17665451
294:19289382
173:16730216
97:vimentin
79:arginine
72:nitrogen
20:against
374:2656247
200:7932409
74:in the
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83:oxygen
63:Basics
420:PMID
379:PMID
326:PMID
290:PMID
196:PMID
169:PMID
34:ACPA
410:doi
369:PMC
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318:doi
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