360:
337:
234:
259:
3036:
2991:
2976:
2961:
3051:
3006:
2946:
3021:
366:
265:
3832:
31:
1613:. The reaction starts when hydrogen peroxide donates an oxygen to the heme group, converting it to an activated form called "Compound I". This compound then oxidizes the chloride ions to form the hypochlorous acid and Compound II, which can be reduced back down to its original heme state. This cycle continues for as long as the immune system requires.
1688:. Since then, there have been over 100 published studies documenting the utility of MPO testing. The 2010 Heslop et al. study reported that measuring both MPO and CRP (C-reactive protein; a general and cardiac-related marker of inflammation) provided added benefit for risk prediction than just measuring CRP alone.
57:
2222:
Kagan VE, Konduru NV, Feng W, Allen BL, Conroy J, Volkov Y, Vlasova II, Belikova NA, Yanamala N, Kapralov A, Tyurina YY, Shi J, Kisin ER, Murray AR, Franks J, Stolz D, Gou P, Klein-Seetharaman J, Fadeel B, Star A, Shvedova AA (May 2010).
2427:
Shaw SA, Vokits BP, Dilger AK, Viet A, Clark CG, Abell LM, et al. (November 2020). "Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase".
1661:. And Heslop et al. reported that elevated MPO levels more than doubled the risk for cardiovascular mortality over a 13-year period. It has also been suggested that myeloperoxidase plays a significant role in the development of the
2298:
Davey CA, Fenna RE (August 1996). "2.3 A resolution X-ray crystal structure of the bisubstrate analogue inhibitor salicylhydroxamic acid bound to human myeloperoxidase: a model for a prereaction complex with hydrogen peroxide".
1901:
Kinkade JM, Pember SO, Barnes KC, Shapira R, Spitznagel JK, Martin LE (Jul 1983). "Differential distribution of distinct forms of myeloperoxidase in different azurophilic granule subpopulations from human neutrophils".
1427:
Myeloperoxidase is found in many different organisms including mammals, birds, fish, reptiles, and amphibians. Myeloperoxidase deficiency is a well-documented disease among humans resulting in impaired immune function.
3035:
2990:
1718:
tests, with the additional benefit of simultaneous detection of multiple autoantibodies relevant to vasculitis. Nonetheless, this method still requires further testing.
1965:
Kutter D, Devaquet P, Vanderstocken G, Paulus JM, Marchal V, Gothot A (2000). "Consequences of total and subtotal myeloperoxidase deficiency: risk or benefit ?".
373:
272:
1319:
2975:
2960:
3050:
2275:
1643:
1338:
3148:
1532:, allaying a concern among clinicians that using nanotubes for targeted delivery of medicines would lead to an unhealthy buildup of nanotubes in tissues.
3091:
3005:
925:
195:
2945:
906:
2015:
2714:
Brennan ML, Penn MS, Van Lente F, Nambi V, Shishehbor MH, Aviles RJ, Goormastic M, Pepoy ML, McErlean ES, Topol EJ, Nissen SE, Hazen SL (Oct 2003).
1586:
Variation in glycosylation and the identity of the heavy chain lead to variations in molecular weight within the 135-200 kDa range. In mice, three
2599:"Myeloperoxidase and C-reactive protein have combined utility for long-term prediction of cardiovascular mortality after coronary angiography"
3852:
3324:
2925:
1817:
1799:
1525:. Following phagocytosis, the immune cells repair and remodel tissues, which can be aided by oxidized products of myeloperoxidase function.
1647:
3020:
1597:
group of Asp 96. Calcium-binding is important for structure of the active site because of Asp 96's close proximity to the catalytic His95
359:
2130:
Davies MJ (February 2021). "Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases".
2095:
Hampton MB, Kettle AJ, Winterbourn CC (Nov 1998). "Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing".
1125:
1132:
336:
3551:
2772:
1946:
2471:
Shin K, Hayasawa H, Lönnerdal B (Mar 2001). "Mutations affecting the calcium-binding site of myeloperoxidase and lactoperoxidase".
1639:
1331:
1729:
has been used traditionally as an MPO inhibitor, but 4-aminobenzoic acid hydrazide (4-ABH) is a more specific inhibitor of MPO.
1786:
1765:
3084:
1298:
1274:
258:
233:
3707:
1782:
54:
3244:
3822:
1761:
1838:
175:
3234:
1621:
372:
271:
3692:
3808:
3795:
3782:
3769:
3756:
3743:
3730:
3480:
3350:
3317:
3077:
2918:
3702:
1292:
365:
264:
3656:
3599:
3463:
3341:
3044:: CRYSTAL STRUCTURE OF HUMAN MYELOPEROXIDASE ISOFORM C CRYSTALLIZED IN SPACE GROUP P2(1) AT PH 5.5 AND 20 DEG C
1197:
970:
183:
1548:
consisting of two 15-kDa light chains and two variable-weight glycosylated heavy chains bound to a prosthetic
1279:
3604:
3468:
3378:
1658:
1468:
951:
2022:
3438:
3388:
3286:
3216:
3173:
3101:
2679:
Lau D, Baldus S (Jul 2006). "Myeloperoxidase and its contributory role in inflammatory vascular disease".
1695:
1579:
bridge at Cys153. The protein forms a deep crevice which holds the heme group at the bottom, as well as a
1343:
3862:
3625:
3544:
3383:
3368:
3239:
1681:
1657:
Recent studies have reported an association between elevated myeloperoxidase levels and the severity of
1267:
247:
3697:
2553:
Zhang R, Brennan ML, Fu X, Aviles RJ, Pearce GL, Penn MS, Topol EJ, Sprecher DL, Hazen SL (Nov 2001).
3310:
3254:
3181:
2911:
2236:
1691:
1397:
2788:
Csernok E, Moosig F (Aug 2014). "Current and emerging techniques for ANCA detection in vasculitis".
2508:"Emerging concepts in the pathogenesis of antineutrophil cytoplasmic antibody-associated vasculitis"
2334:
Mathy-Hartert M, Bourgeois E, GrĂĽlke S, Deby-Dupont G, Caudron I, Deby C, et al. (April 1998).
162:
3661:
3229:
3113:
2999:: CRYSTAL STRUCTURE OF HUMAN MYELOPEROXIDASE ISOFORM C COMPLEXED WITH CYANIDE AND BROMIDE AT PH 4.0
1937:
Le T, Bhushan V, Sochat M, Damisch K, Abrams J, Kallianos K, Boqambar H, Qiu, C, Coleman C (2021).
1710:, which can otherwise have a similar appearance. In the case of screening patients for vasculitis,
1401:
1392:
activity, including hypochlorous acid, the sodium salt of which is the chemical in bleach. It is a
1295:
1219:
3857:
3594:
3453:
2813:
2745:
2535:
2453:
2155:
1990:
1883:
1715:
1545:
207:
2048:"Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative cross-linking of proteins"
1108:
1087:
1061:
1040:
2883:
2862:
2805:
2768:
2737:
2696:
2661:
2620:
2576:
2527:
2488:
2445:
2409:
2357:
2316:
2262:
2204:
2147:
2112:
2077:
1982:
1942:
1919:
1875:
1625:
1569:
1484:
1476:
1464:
1441:
1437:
1286:
155:
47:
2175:"Myeloperoxidase: an oxidative pathway for generating dysfunctional high-density lipoprotein"
3640:
3635:
3609:
3537:
3363:
3163:
2852:
2844:
2797:
2727:
2688:
2651:
2610:
2566:
2519:
2480:
2437:
2399:
2391:
2347:
2308:
2252:
2244:
2225:"Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation"
2194:
2186:
2139:
2104:
2067:
2059:
1974:
1911:
1865:
1507:
1503:
1460:
1385:
452:
383:
327:
282:
3069:
1583:
pocket at the entrance to the distal heme cavity which carries out its catalytic activity.
1255:
3687:
3671:
3584:
3498:
3493:
3443:
3358:
3133:
1703:
1662:
1529:
1480:
427:
3302:
1575:. Together, the light and heavy chains form two identical 73-kDa monomers connected by a
1231:
203:
2240:
1202:
3836:
3725:
3666:
3333:
2857:
2832:
2656:
2639:
2404:
2380:"Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention"
2379:
2352:
2335:
2257:
2224:
2199:
2174:
1711:
1314:
2507:
2072:
2047:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
668:
663:
658:
653:
648:
643:
3846:
3630:
3589:
3484:
3290:
3196:
2892:
2692:
2457:
2159:
2143:
1915:
1515:
1389:
1377:
630:
2817:
2749:
2539:
1994:
1887:
3579:
3206:
3137:
445:
224:
1680:
An initial 2003 study suggested that MPO could serve as a sensitive predictor for
187:
2523:
211:
3803:
3738:
3574:
3401:
3201:
3186:
3153:
3105:
2555:"Association between myeloperoxidase levels and risk of coronary artery disease"
1822:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1804:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1610:
1598:
1580:
1572:
1565:
1557:
1409:
1381:
3831:
2833:"Mechanism of inactivation of myeloperoxidase by 4-aminobenzoic acid hydrazide"
2615:
2598:
1560:. Both are proteolytically generated from the precursor peptide encoded by the
528:
3458:
3337:
2984:: CRYSTAL STRUCTURE OF CYANIDE-BOUND HUMAN MYELOPEROXIDASE ISOFORM C AT PH 5.5
2969:: CRYSTAL STRUCTURE OF BROMIDE-BOUND HUMAN MYELOPEROXIDASE ISOFORM C AT PH 5.5
2441:
1685:
1635:
1541:
1528:
Myeloperoxidase is the first and so far only human enzyme known to break down
1519:
1363:
344:
241:
191:
3059:: X-RAY CRYSTAL STRUCTURE OF CANINE MYELOPEROXIDASE AT 3 ANGSTROMS RESOLUTION
2571:
2554:
2108:
3777:
3751:
3267:
3224:
2801:
1553:
1522:
1511:
1488:
870:
588:
466:
411:
398:
310:
297:
199:
2809:
2741:
2700:
2665:
2624:
2580:
2531:
2492:
2484:
2449:
2413:
2276:"Scientists Devise A Means For Human Bodies To Break Down Carbon Nanotubes"
2266:
2208:
2151:
1986:
1879:
2866:
2395:
2361:
2336:"Purification of myeloperoxidase from equine polymorphonuclear leucocytes"
2320:
2248:
2116:
2081:
1923:
1172:
1167:
30:
3373:
3191:
3143:
3127:
2732:
2715:
1738:
1707:
1702:
lineage. Myeloperoxidase staining is still important in the diagnosis of
1694:
staining for myeloperoxidase used to be administered in the diagnosis of
1669:
1651:
1638:, most prominently three clinically and pathologically recognized forms:
1631:
1594:
1587:
1496:
1492:
1472:
1453:
1393:
1156:
1015:
996:
1870:
1853:
1243:
3262:
2897:
2887:
1699:
1576:
1262:
982:
937:
2848:
2312:
2190:
2063:
1978:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
3790:
3560:
1665:
1417:
1366:
1326:
1238:
1226:
1214:
1140:
892:
3764:
3518:
3513:
3508:
3503:
3014:: STRUCTURAL ANALYSES OF HUMAN MYELOPEROXIDASE-THIOCYANATE COMPLEX
1726:
1456:
1413:
2716:"Prognostic value of myeloperoxidase in patients with chest pain"
1436:
MPO is a member of the XPO subfamily of peroxidases and produces
855:
851:
3431:
3426:
3421:
3416:
3411:
3406:
3396:
2954:: CRYOGENIC CRYSTAL STRUCTURE OF HUMAN MYELOPEROXIDASE ISOFORM C
1549:
1405:
1373:
1250:
179:
3533:
3306:
3073:
2907:
1624:
is a hereditary deficiency of the enzyme, which predisposes to
2903:
1698:
to demonstrate that the leukemic cells were derived from the
2882:
Overview of all the structural information available in the
1408:
pigment, which causes its green color in secretions rich in
3529:
2046:
Heinecke JW, Li W, Francis GA, Goldstein JA (Jun 1993).
435:
1404:
during degranulation. Neutrophil myeloperoxidase has a
3820:
2767:. London: Greenwich Medical Media. pp. 325–326.
1941:(2021 ed.). New York: McGraw Hill. p. 109.
1634:
against MPO have been implicated in various types of
600:
1514:
and inflammation. In addition, MPO mediates protein
1388:), and produces hypohalous acids to carry out their
3716:
3680:
3649:
3618:
3567:
3479:
3349:
3253:
3215:
3172:
3162:
3112:
3029:: HUMAN MYELOPEROXIDASE-CYANIDE-THIOCYANATE COMPLEX
2765:
Manual of
Diagnostic Antibodies for Immunohistology
2473:
1904:
1420:. The green color contributed to its outdated name
1337:
1325:
1313:
1308:
1285:
1273:
1261:
1249:
1237:
1225:
1213:
1208:
1196:
1191:
1186:
1101:
1080:
1054:
1033:
2644:Arteriosclerosis, Thrombosis, and Vascular Biology
1778:
1776:
1774:
1757:
1755:
1753:
2173:Shao B, Oda MN, Oram JF, Heinecke JW (Mar 2010).
1650:(ANCAs), though ANCAs have also been detected in
382:
281:
2831:Kettle AJ, Gedye CA, Winterbourn CC (Jan 1997).
2592:
2590:
2373:
2371:
1552:group complex with calcium ions, arranged as a
1502:However, this hypochlorous acid may also cause
2384:Journal of Clinical Biochemistry and Nutrition
1960:
1958:
1783:GRCm38: Ensembl release 89: ENSMUSG00000009350
821:respiratory burst involved in defense response
3545:
3318:
3085:
2919:
2603:Journal of the American College of Cardiology
1644:eosinophilic granulomatosis with polyangiitis
1491:, so they are used by the neutrophil to kill
8:
3149:Bactericidal permeability-increasing protein
2640:"Myeloperoxidase and cardiovascular disease"
2597:Heslop CL, Frohlich JJ, Hill JS (Mar 2010).
2506:Flint SM, McKinney EF, Smith KG (Mar 2015).
2293:
2291:
1714:have demonstrated comparable sensitivity to
1706:, contrasting with the negative staining of
1762:GRCh38: Ensembl release 89: ENSG00000005381
1642:(GPA), microscopic polyangiitis (MPA); and
1506:in host tissue. Moreover, MPO oxidation of
1463:if Br- is present) during the neutrophil's
756:low-density lipoprotein particle remodeling
3552:
3538:
3530:
3325:
3311:
3303:
3169:
3092:
3078:
3070:
2926:
2912:
2904:
1590:exist, differing only by the heavy chain.
1518:and the formation of 3-chlorotyrosine and
1305:
866:
626:
423:
322:
219:
65:
2856:
2731:
2655:
2614:
2570:
2403:
2351:
2256:
2198:
2071:
1869:
543:fetal liver hematopoietic progenitor cell
2010:
2008:
2006:
2004:
1833:
1831:
1400:of the neutrophil and released into the
781:negative regulation of apoptotic process
730:intracellular membrane-bounded organelle
3827:
2941:
2340:Canadian Journal of Veterinary Research
1749:
18:Mammalian protein found in Homo sapiens
2763:Leong AS, Cooper K, Leong, FJ (2003).
1648:anti-neutrophil cytoplasmic antibodies
1510:-I reduces HDL-mediated inhibition of
1380:. MPO is most abundantly expressed in
1183:
776:hypochlorous acid biosynthetic process
20:
2052:The Journal of Clinical Investigation
1646:(EGPA). Antibodies are also known as
387:
348:
343:
286:
245:
240:
7:
2430:Bioorganic & Medicinal Chemistry
567:vestibular membrane of cochlear duct
2720:The New England Journal of Medicine
1609:The central heme group acts as the
801:hydrogen peroxide catabolic process
2657:10.1161/01.ATV.0000163262.83456.6d
2638:Nicholls SJ, Hazen SL (Jun 2005).
1098:
1077:
1051:
1030:
1006:
987:
961:
942:
916:
897:
605:
523:
461:
440:
14:
1854:"Myeloperoxidase: friend and foe"
1369:that in humans is encoded by the
3830:
3049:
3034:
3019:
3004:
2989:
2974:
2959:
2944:
2693:10.1016/j.pharmthera.2005.06.023
2144:10.1016/j.pharmthera.2020.107685
2016:"Mouse MPO EasyTestTM ELISA Kit"
1640:granulomatosis with polyangiitis
371:
364:
358:
335:
270:
263:
257:
232:
29:
2681:Pharmacology & Therapeutics
2512:Current Opinion in Rheumatology
2179:Chemical Research in Toxicology
2132:Pharmacology & Therapeutics
766:response to mechanical stimulus
1939:First Aid for the USMLE Step 1
1839:"Entrez Gene: Myeloperoxidase"
1568:and contain the modified iron
786:response to lipopolysaccharide
771:removal of superoxide radicals
589:More reference expression data
489:olfactory zone of nasal mucosa
1:
3245:Eosinophil-derived neurotoxin
2274:Clay Dillow (April 6, 2010).
831:defense response to bacterium
791:response to gold nanoparticle
356:
255:
3853:Genes on human chromosome 17
2790:Nature Reviews. Rheumatology
2524:10.1097/BOR.0000000000000145
1916:10.1016/0006-291x(83)91627-3
1858:Journal of Leukocyte Biology
1684:in patients presenting with
806:response to oxidative stress
3235:Eosinophil cationic protein
1654:of the perinuclear region.
1564:gene. The light chains are
1471:. Furthermore, it oxidizes
3879:
2616:10.1016/j.jacc.2009.11.050
2378:Davies MJ (January 2011).
1622:Myeloperoxidase deficiency
1593:One of the ligands is the
1544:MPO protein is a cationic
761:defense response to fungus
3708:Michaelis–Menten kinetics
3280:
2939:
2896:(Myeloperoxidase) at the
2442:10.1016/j.bmc.2020.115723
1852:Klebanoff SJ (May 2005).
1818:"Mouse PubMed Reference:"
1800:"Human PubMed Reference:"
1475:to tyrosyl radical using
1304:
1171:
1166:
1162:
1155:
1139:
1120:
1105:
1084:
1073:
1058:
1037:
1026:
1013:
1009:
994:
990:
981:
968:
964:
949:
945:
936:
923:
919:
904:
900:
891:
876:
869:
865:
849:
629:
625:
613:
608:
599:
586:
535:
526:
473:
464:
434:
426:
422:
405:
392:
355:
334:
325:
321:
304:
291:
254:
231:
222:
218:
173:
170:
160:
153:
148:
73:
68:
51:
46:
41:
37:
28:
23:
3600:Diffusion-limited enzyme
3464:Iodothyronine deiodinase
2572:10.1001/jama.286.17.2136
2109:10.1182/blood.V92.9.3007
1487:and tyrosyl radical are
1467:. It requires heme as a
1126:Chr 17: 58.27 – 58.28 Mb
836:neutrophil degranulation
740:phagocytic vesicle lumen
3469:Iodotyrosine deiodinase
3379:Cytochrome c peroxidase
2837:The Biochemical Journal
2802:10.1038/nrrheum.2014.78
1659:coronary artery disease
1133:Chr 11: 87.68 – 87.7 Mb
725:azurophil granule lumen
664:oxidoreductase activity
3439:Horseradish peroxidase
3389:Glutathione peroxidase
3287:platelet alpha-granule
2485:10.1006/bbrc.2001.4448
1712:flow cytometric assays
1696:acute myeloid leukemia
841:cell redox homeostasis
3693:Eadie–Hofstee diagram
3626:Allosteric regulation
3384:Eosinophil peroxidase
3369:Fatty-acid peroxidase
3240:Eosinophil peroxidase
2396:10.3164/jcbn.11-006FR
2249:10.1038/nnano.2010.44
2229:Nature Nanotechnology
1682:myocardial infarction
1617:Clinical significance
705:extracellular exosome
389:11 52.22 cM|11 C
350:Chromosome 11 (mouse)
248:Chromosome 17 (human)
3703:Lineweaver–Burk plot
3182:Alkaline phosphatase
3114:Azurophilic granules
2733:10.1056/NEJMoa035003
1398:azurophilic granules
715:extracellular region
69:List of PDB id codes
42:Available structures
3230:Major basic protein
2307:(33): 10967–10973.
2241:2010NatNa...5..354K
1871:10.1189/jlb.1204697
1692:Immunohistochemical
1402:extracellular space
720:extracellular space
669:peroxidase activity
3662:Enzyme superfamily
3595:Enzyme promiscuity
3454:Thyroid peroxidase
1967:Acta Haematologica
1716:immunofluorescence
1605:Reaction mechanism
1396:protein stored in
971:ENSMUSG00000009350
749:Biological process
678:Cellular component
637:Molecular function
539:tibiofemoral joint
3818:
3817:
3527:
3526:
3300:
3299:
3276:
3275:
3164:Specific granules
3067:
3066:
2849:10.1042/bj3210503
2313:10.1021/bi960577m
2191:10.1021/tx9003775
2064:10.1172/JCI116531
1979:10.1159/000041062
1722:Inhibitors of MPO
1626:immune deficiency
1570:protoporphyrin IX
1485:Hypochlorous acid
1477:hydrogen peroxide
1465:respiratory burst
1442:hydrogen peroxide
1438:hypochlorous acid
1386:white blood cells
1353:
1352:
1349:
1348:
1268:metabolic pathway
1182:
1181:
1178:
1177:
1151:
1150:
1116:
1115:
1095:
1094:
1069:
1068:
1048:
1047:
1022:
1021:
1003:
1002:
977:
976:
958:
957:
932:
931:
913:
912:
861:
860:
796:response to yeast
700:azurophil granule
695:secretory granule
659:chromatin binding
644:metal ion binding
621:
620:
617:
616:
595:
594:
582:
581:
520:
519:
481:bone marrow cells
418:
417:
317:
316:
166:, myeloperoxidase
144:
143:
140:
139:
52:Ortholog search:
3870:
3835:
3834:
3826:
3698:Hanes–Woolf plot
3641:Enzyme activator
3636:Enzyme inhibitor
3610:Enzyme catalysis
3554:
3547:
3540:
3531:
3364:NADPH peroxidase
3327:
3320:
3313:
3304:
3170:
3134:serine proteases
3100:Contents of the
3094:
3087:
3080:
3071:
3053:
3038:
3023:
3008:
2993:
2978:
2963:
2948:
2928:
2921:
2914:
2905:
2871:
2870:
2860:
2828:
2822:
2821:
2785:
2779:
2778:
2760:
2754:
2753:
2735:
2726:(17): 1595–604.
2711:
2705:
2704:
2676:
2670:
2669:
2659:
2635:
2629:
2628:
2618:
2594:
2585:
2584:
2574:
2550:
2544:
2543:
2503:
2497:
2496:
2468:
2462:
2461:
2424:
2418:
2417:
2407:
2375:
2366:
2365:
2355:
2331:
2325:
2324:
2295:
2286:
2283:
2270:
2260:
2219:
2213:
2212:
2202:
2170:
2164:
2163:
2127:
2121:
2120:
2092:
2086:
2085:
2075:
2043:
2037:
2036:
2034:
2033:
2027:
2021:. Archived from
2020:
2012:
1999:
1998:
1962:
1953:
1952:
1934:
1928:
1927:
1898:
1892:
1891:
1873:
1849:
1843:
1842:
1835:
1826:
1825:
1814:
1808:
1807:
1796:
1790:
1780:
1769:
1759:
1530:carbon nanotubes
1504:oxidative damage
1461:hypobromous acid
1306:
1184:
1164:
1163:
1135:
1128:
1111:
1099:
1090:
1078:
1074:RefSeq (protein)
1064:
1052:
1043:
1031:
1007:
988:
962:
943:
917:
898:
867:
826:defense response
816:response to food
627:
606:
591:
531:
529:Top expressed in
524:
469:
467:Top expressed in
462:
441:
424:
414:
401:
390:
375:
368:
362:
351:
339:
323:
313:
300:
289:
274:
267:
261:
250:
236:
220:
214:
165:
158:
135:
66:
60:
39:
38:
33:
21:
3878:
3877:
3873:
3872:
3871:
3869:
3868:
3867:
3843:
3842:
3841:
3829:
3821:
3819:
3814:
3726:Oxidoreductases
3712:
3688:Enzyme kinetics
3676:
3672:List of enzymes
3645:
3614:
3585:Catalytic triad
3563:
3558:
3528:
3523:
3475:
3449:Myeloperoxidase
3444:Lactoperoxidase
3359:NADH peroxidase
3345:
3334:Oxidoreductases
3331:
3301:
3296:
3272:
3249:
3211:
3158:
3123:Myeloperoxidase
3108:
3098:
3068:
3063:
3060:
3054:
3045:
3039:
3030:
3024:
3015:
3009:
3000:
2994:
2985:
2979:
2970:
2964:
2955:
2949:
2935:
2932:
2879:
2874:
2830:
2829:
2825:
2787:
2786:
2782:
2775:
2762:
2761:
2757:
2713:
2712:
2708:
2678:
2677:
2673:
2637:
2636:
2632:
2596:
2595:
2588:
2565:(17): 2136–42.
2552:
2551:
2547:
2505:
2504:
2500:
2470:
2469:
2465:
2426:
2425:
2421:
2377:
2376:
2369:
2333:
2332:
2328:
2297:
2296:
2289:
2280:Popular Science
2273:
2221:
2220:
2216:
2172:
2171:
2167:
2129:
2128:
2124:
2094:
2093:
2089:
2045:
2044:
2040:
2031:
2029:
2025:
2018:
2014:
2013:
2002:
1964:
1963:
1956:
1949:
1936:
1935:
1931:
1900:
1899:
1895:
1851:
1850:
1846:
1837:
1836:
1829:
1816:
1815:
1811:
1798:
1797:
1793:
1781:
1772:
1760:
1751:
1747:
1735:
1724:
1704:myeloid sarcoma
1678:
1663:atherosclerotic
1619:
1607:
1538:
1481:oxidizing agent
1451:
1447:
1434:
1422:verdoperoxidase
1356:Myeloperoxidase
1187:Myeloperoxidase
1173:View/Edit Mouse
1168:View/Edit Human
1131:
1124:
1121:Location (UCSC)
1107:
1086:
1060:
1039:
952:ENSG00000005381
845:
744:
673:
654:heparin binding
587:
578:
573:
569:
565:
561:
557:
553:
549:
545:
541:
527:
516:
511:
507:
503:
499:
495:
491:
487:
483:
479:
477:trabecular bone
465:
409:
396:
388:
378:
377:
376:
369:
349:
326:Gene location (
308:
295:
287:
277:
276:
275:
268:
246:
223:Gene location (
212:MPO - orthologs
174:
161:
154:
75:
53:
19:
12:
11:
5:
3876:
3874:
3866:
3865:
3860:
3855:
3845:
3844:
3840:
3839:
3816:
3815:
3813:
3812:
3799:
3786:
3773:
3760:
3747:
3734:
3720:
3718:
3714:
3713:
3711:
3710:
3705:
3700:
3695:
3690:
3684:
3682:
3678:
3677:
3675:
3674:
3669:
3664:
3659:
3653:
3651:
3650:Classification
3647:
3646:
3644:
3643:
3638:
3633:
3628:
3622:
3620:
3616:
3615:
3613:
3612:
3607:
3602:
3597:
3592:
3587:
3582:
3577:
3571:
3569:
3565:
3564:
3559:
3557:
3556:
3549:
3542:
3534:
3525:
3524:
3522:
3521:
3516:
3511:
3506:
3501:
3496:
3490:
3488:
3477:
3476:
3474:
3473:
3472:
3471:
3466:
3456:
3451:
3446:
3441:
3436:
3435:
3434:
3429:
3424:
3419:
3414:
3409:
3404:
3399:
3386:
3381:
3376:
3371:
3366:
3361:
3355:
3353:
3347:
3346:
3332:
3330:
3329:
3322:
3315:
3307:
3298:
3297:
3295:
3294:
3281:
3278:
3277:
3274:
3273:
3271:
3270:
3265:
3259:
3257:
3251:
3250:
3248:
3247:
3242:
3237:
3232:
3227:
3221:
3219:
3213:
3212:
3210:
3209:
3204:
3199:
3194:
3189:
3184:
3178:
3176:
3167:
3160:
3159:
3157:
3156:
3151:
3146:
3141:
3130:
3125:
3119:
3117:
3110:
3109:
3099:
3097:
3096:
3089:
3082:
3074:
3065:
3064:
3062:
3061:
3055:
3048:
3046:
3040:
3033:
3031:
3025:
3018:
3016:
3010:
3003:
3001:
2995:
2988:
2986:
2980:
2973:
2971:
2965:
2958:
2956:
2950:
2943:
2940:
2937:
2936:
2933:
2931:
2930:
2923:
2916:
2908:
2902:
2901:
2878:
2877:External links
2875:
2873:
2872:
2823:
2796:(8): 494–501.
2780:
2773:
2755:
2706:
2671:
2650:(6): 1102–11.
2630:
2609:(11): 1102–9.
2586:
2545:
2518:(2): 197–203.
2498:
2463:
2436:(22): 115723.
2419:
2367:
2346:(2): 127–132.
2326:
2287:
2285:
2284:
2214:
2165:
2122:
2103:(9): 3007–17.
2087:
2058:(6): 2866–72.
2038:
2000:
1954:
1947:
1929:
1910:(1): 296–303.
1893:
1864:(5): 598–625.
1844:
1827:
1809:
1791:
1770:
1748:
1746:
1743:
1742:
1741:
1734:
1731:
1723:
1720:
1677:
1674:
1668:and rendering
1618:
1615:
1606:
1603:
1546:heterotetramer
1537:
1534:
1449:
1445:
1433:
1430:
1384:(a subtype of
1351:
1350:
1347:
1346:
1341:
1335:
1334:
1329:
1323:
1322:
1317:
1311:
1310:
1302:
1301:
1290:
1283:
1282:
1277:
1271:
1270:
1265:
1259:
1258:
1253:
1247:
1246:
1241:
1235:
1234:
1229:
1223:
1222:
1217:
1211:
1210:
1206:
1205:
1200:
1194:
1193:
1189:
1188:
1180:
1179:
1176:
1175:
1170:
1160:
1159:
1153:
1152:
1149:
1148:
1146:
1144:
1137:
1136:
1129:
1122:
1118:
1117:
1114:
1113:
1103:
1102:
1096:
1093:
1092:
1082:
1081:
1075:
1071:
1070:
1067:
1066:
1056:
1055:
1049:
1046:
1045:
1035:
1034:
1028:
1024:
1023:
1020:
1019:
1011:
1010:
1004:
1001:
1000:
992:
991:
985:
979:
978:
975:
974:
966:
965:
959:
956:
955:
947:
946:
940:
934:
933:
930:
929:
921:
920:
914:
911:
910:
902:
901:
895:
889:
888:
883:
878:
874:
873:
863:
862:
859:
858:
847:
846:
844:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
752:
750:
746:
745:
743:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
692:
687:
681:
679:
675:
674:
672:
671:
666:
661:
656:
651:
646:
640:
638:
634:
633:
623:
622:
619:
618:
615:
614:
611:
610:
603:
597:
596:
593:
592:
584:
583:
580:
579:
577:
576:
572:
568:
564:
560:
556:
552:
548:
544:
540:
536:
533:
532:
521:
518:
517:
515:
514:
510:
509:amniotic fluid
506:
502:
498:
494:
490:
486:
482:
478:
474:
471:
470:
458:
457:
449:
438:
432:
431:
428:RNA expression
420:
419:
416:
415:
407:
403:
402:
394:
391:
386:
380:
379:
370:
363:
357:
353:
352:
347:
341:
340:
332:
331:
319:
318:
315:
314:
306:
302:
301:
293:
290:
285:
279:
278:
269:
262:
256:
252:
251:
244:
238:
237:
229:
228:
216:
215:
172:
168:
167:
159:
151:
150:
146:
145:
142:
141:
138:
137:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
3875:
3864:
3861:
3859:
3856:
3854:
3851:
3850:
3848:
3838:
3833:
3828:
3824:
3810:
3806:
3805:
3800:
3797:
3793:
3792:
3787:
3784:
3780:
3779:
3774:
3771:
3767:
3766:
3761:
3758:
3754:
3753:
3748:
3745:
3741:
3740:
3735:
3732:
3728:
3727:
3722:
3721:
3719:
3715:
3709:
3706:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3685:
3683:
3679:
3673:
3670:
3668:
3667:Enzyme family
3665:
3663:
3660:
3658:
3655:
3654:
3652:
3648:
3642:
3639:
3637:
3634:
3632:
3631:Cooperativity
3629:
3627:
3624:
3623:
3621:
3617:
3611:
3608:
3606:
3603:
3601:
3598:
3596:
3593:
3591:
3590:Oxyanion hole
3588:
3586:
3583:
3581:
3578:
3576:
3573:
3572:
3570:
3566:
3562:
3555:
3550:
3548:
3543:
3541:
3536:
3535:
3532:
3520:
3517:
3515:
3512:
3510:
3507:
3505:
3502:
3500:
3497:
3495:
3492:
3491:
3489:
3486:
3485:peroxiredoxin
3482:
3478:
3470:
3467:
3465:
3462:
3461:
3460:
3457:
3455:
3452:
3450:
3447:
3445:
3442:
3440:
3437:
3433:
3430:
3428:
3425:
3423:
3420:
3418:
3415:
3413:
3410:
3408:
3405:
3403:
3400:
3398:
3395:
3392:
3391:
3390:
3387:
3385:
3382:
3380:
3377:
3375:
3372:
3370:
3367:
3365:
3362:
3360:
3357:
3356:
3354:
3352:
3348:
3343:
3339:
3335:
3328:
3323:
3321:
3316:
3314:
3309:
3308:
3305:
3293:
3292:
3291:dense granule
3288:
3283:
3282:
3279:
3269:
3266:
3264:
3261:
3260:
3258:
3256:
3252:
3246:
3243:
3241:
3238:
3236:
3233:
3231:
3228:
3226:
3223:
3222:
3220:
3218:
3214:
3208:
3205:
3203:
3200:
3198:
3197:NADPH oxidase
3195:
3193:
3190:
3188:
3185:
3183:
3180:
3179:
3177:
3175:
3171:
3168:
3165:
3161:
3155:
3152:
3150:
3147:
3145:
3142:
3139:
3135:
3131:
3129:
3126:
3124:
3121:
3120:
3118:
3115:
3111:
3107:
3103:
3095:
3090:
3088:
3083:
3081:
3076:
3075:
3072:
3058:
3052:
3047:
3043:
3037:
3032:
3028:
3022:
3017:
3013:
3007:
3002:
2998:
2992:
2987:
2983:
2977:
2972:
2968:
2962:
2957:
2953:
2947:
2942:
2938:
2929:
2924:
2922:
2917:
2915:
2910:
2909:
2906:
2899:
2895:
2894:
2889:
2885:
2881:
2880:
2876:
2868:
2864:
2859:
2854:
2850:
2846:
2842:
2838:
2834:
2827:
2824:
2819:
2815:
2811:
2807:
2803:
2799:
2795:
2791:
2784:
2781:
2776:
2774:1-84110-100-1
2770:
2766:
2759:
2756:
2751:
2747:
2743:
2739:
2734:
2729:
2725:
2721:
2717:
2710:
2707:
2702:
2698:
2694:
2690:
2686:
2682:
2675:
2672:
2667:
2663:
2658:
2653:
2649:
2645:
2641:
2634:
2631:
2626:
2622:
2617:
2612:
2608:
2604:
2600:
2593:
2591:
2587:
2582:
2578:
2573:
2568:
2564:
2560:
2556:
2549:
2546:
2541:
2537:
2533:
2529:
2525:
2521:
2517:
2513:
2509:
2502:
2499:
2494:
2490:
2486:
2482:
2479:(4): 1024–9.
2478:
2474:
2467:
2464:
2459:
2455:
2451:
2447:
2443:
2439:
2435:
2431:
2423:
2420:
2415:
2411:
2406:
2401:
2397:
2393:
2389:
2385:
2381:
2374:
2372:
2368:
2363:
2359:
2354:
2349:
2345:
2341:
2337:
2330:
2327:
2322:
2318:
2314:
2310:
2306:
2302:
2294:
2292:
2288:
2281:
2277:
2272:
2271:
2268:
2264:
2259:
2254:
2250:
2246:
2242:
2238:
2234:
2230:
2226:
2218:
2215:
2210:
2206:
2201:
2196:
2192:
2188:
2185:(3): 447–54.
2184:
2180:
2176:
2169:
2166:
2161:
2157:
2153:
2149:
2145:
2141:
2137:
2133:
2126:
2123:
2118:
2114:
2110:
2106:
2102:
2098:
2091:
2088:
2083:
2079:
2074:
2069:
2065:
2061:
2057:
2053:
2049:
2042:
2039:
2028:on 2016-03-03
2024:
2017:
2011:
2009:
2007:
2005:
2001:
1996:
1992:
1988:
1984:
1980:
1976:
1972:
1968:
1961:
1959:
1955:
1950:
1948:9781260467529
1944:
1940:
1933:
1930:
1925:
1921:
1917:
1913:
1909:
1905:
1897:
1894:
1889:
1885:
1881:
1877:
1872:
1867:
1863:
1859:
1855:
1848:
1845:
1840:
1834:
1832:
1828:
1823:
1819:
1813:
1810:
1805:
1801:
1795:
1792:
1788:
1784:
1779:
1777:
1775:
1771:
1767:
1763:
1758:
1756:
1754:
1750:
1744:
1740:
1737:
1736:
1732:
1730:
1728:
1721:
1719:
1717:
1713:
1709:
1705:
1701:
1697:
1693:
1689:
1687:
1683:
1676:Medical tests
1675:
1673:
1671:
1667:
1664:
1660:
1655:
1653:
1649:
1645:
1641:
1637:
1633:
1629:
1627:
1623:
1616:
1614:
1612:
1604:
1602:
1600:
1596:
1591:
1589:
1584:
1582:
1578:
1574:
1571:
1567:
1563:
1559:
1555:
1551:
1547:
1543:
1535:
1533:
1531:
1526:
1524:
1521:
1517:
1516:nitrosylation
1513:
1509:
1505:
1500:
1498:
1494:
1490:
1486:
1482:
1478:
1474:
1470:
1466:
1462:
1458:
1455:
1443:
1439:
1431:
1429:
1425:
1423:
1419:
1415:
1411:
1407:
1403:
1399:
1395:
1391:
1390:antimicrobial
1387:
1383:
1379:
1378:chromosome 17
1375:
1372:
1368:
1365:
1361:
1357:
1345:
1342:
1340:
1336:
1333:
1330:
1328:
1324:
1321:
1318:
1316:
1312:
1307:
1303:
1300:
1297:
1294:
1291:
1288:
1284:
1281:
1278:
1276:
1272:
1269:
1266:
1264:
1260:
1257:
1254:
1252:
1248:
1245:
1244:NiceZyme view
1242:
1240:
1236:
1233:
1230:
1228:
1224:
1221:
1218:
1216:
1212:
1207:
1204:
1201:
1199:
1195:
1190:
1185:
1174:
1169:
1165:
1161:
1158:
1154:
1147:
1145:
1142:
1138:
1134:
1130:
1127:
1123:
1119:
1112:
1110:
1104:
1100:
1097:
1091:
1089:
1083:
1079:
1076:
1072:
1065:
1063:
1057:
1053:
1050:
1044:
1042:
1036:
1032:
1029:
1027:RefSeq (mRNA)
1025:
1018:
1017:
1012:
1008:
1005:
999:
998:
993:
989:
986:
984:
980:
973:
972:
967:
963:
960:
954:
953:
948:
944:
941:
939:
935:
928:
927:
922:
918:
915:
909:
908:
903:
899:
896:
894:
890:
887:
884:
882:
879:
875:
872:
868:
864:
857:
853:
848:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
753:
751:
748:
747:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
685:mitochondrion
683:
682:
680:
677:
676:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
641:
639:
636:
635:
632:
631:Gene ontology
628:
624:
612:
607:
604:
602:
598:
590:
585:
574:
570:
566:
562:
558:
554:
551:body of femur
550:
546:
542:
538:
537:
534:
530:
525:
522:
512:
508:
504:
500:
496:
492:
488:
484:
480:
476:
475:
472:
468:
463:
460:
459:
456:
454:
450:
448:
447:
443:
442:
439:
437:
433:
429:
425:
421:
413:
408:
404:
400:
395:
385:
381:
374:
367:
361:
354:
346:
342:
338:
333:
329:
324:
320:
312:
307:
303:
299:
294:
284:
280:
273:
266:
260:
253:
249:
243:
239:
235:
230:
226:
221:
217:
213:
209:
205:
201:
197:
193:
189:
185:
181:
177:
169:
164:
157:
152:
147:
136:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
16:
3863:Hemoproteins
3804:Translocases
3801:
3788:
3775:
3762:
3749:
3739:Transferases
3736:
3723:
3580:Binding site
3448:
3393:
3284:
3207:Cathelicidin
3138:Proteinase 3
3122:
3106:granulocytes
3056:
3041:
3026:
3011:
2996:
2981:
2966:
2951:
2891:
2843:(2): 503–8.
2840:
2836:
2826:
2793:
2789:
2783:
2764:
2758:
2723:
2719:
2709:
2687:(1): 16–26.
2684:
2680:
2674:
2647:
2643:
2633:
2606:
2602:
2562:
2558:
2548:
2515:
2511:
2501:
2476:
2472:
2466:
2433:
2429:
2422:
2387:
2383:
2343:
2339:
2329:
2304:
2301:Biochemistry
2300:
2279:
2235:(5): 354–9.
2232:
2228:
2217:
2182:
2178:
2168:
2135:
2131:
2125:
2100:
2096:
2090:
2055:
2051:
2041:
2030:. Retrieved
2023:the original
1970:
1966:
1938:
1932:
1907:
1903:
1896:
1861:
1857:
1847:
1821:
1812:
1803:
1794:
1725:
1690:
1679:
1656:
1630:
1620:
1608:
1592:
1585:
1566:glycosylated
1561:
1558:heterodimers
1539:
1527:
1501:
1440:(HOCl) from
1435:
1426:
1421:
1370:
1359:
1355:
1354:
1232:BRENDA entry
1106:
1085:
1059:
1038:
1014:
995:
969:
950:
924:
905:
885:
880:
811:human ageing
649:heme binding
451:
444:
171:External IDs
74:
15:
3575:Active site
3351:1.11.1.1-14
3338:peroxidases
3202:Collagenase
3187:Lactoferrin
3154:Collagenase
2934:PDB gallery
2390:(1): 8–19.
1973:(1): 10–5.
1611:active site
1581:hydrophobic
1573:active site
1410:neutrophils
1382:neutrophils
1220:IntEnz view
1192:Identifiers
563:human fetus
559:bone marrow
555:ankle joint
547:granulocyte
497:granulocyte
410:87,695,239
397:87,684,407
309:58,280,935
296:58,269,855
149:Identifiers
3847:Categories
3778:Isomerases
3752:Hydrolases
3619:Regulation
3459:Deiodinase
3217:Eosinophil
3174:Neutrophil
2138:: 107685.
2032:2015-08-06
1789:, May 2017
1768:, May 2017
1745:References
1686:chest pain
1672:unstable.
1636:vasculitis
1632:Antibodies
1599:side chain
1523:crosslinks
1520:dityrosine
1495:and other
1412:, such as
1364:peroxidase
1289:structures
1256:KEGG entry
455:(ortholog)
192:HomoloGene
3858:EC 1.11.1
3657:EC number
3481:1.11.1.15
3285:see also
3268:Histamine
3225:Cathepsin
3128:Defensins
2458:222145838
2160:221865058
1708:lymphomas
1554:homodimer
1536:Structure
1512:apoptosis
1497:pathogens
1489:cytotoxic
1459:(Cl) (or
1394:lysosomal
1209:Databases
1109:NP_034954
1088:NP_000241
1062:NM_010824
1041:NM_000250
871:Orthologs
735:cytoplasm
200:GeneCards
3681:Kinetics
3605:Cofactor
3568:Activity
3374:Catalase
3255:Basophil
3192:Lysozyme
3144:Lysozyme
3132:neutral
3102:granules
2818:25292707
2810:24890776
2750:22084078
2742:14573731
2701:16476484
2666:15790935
2625:20223364
2581:11694155
2540:20296651
2532:25629443
2493:11237766
2450:33007547
2414:21297906
2267:20364135
2209:20043647
2152:32961264
1995:36776058
1987:11111115
1888:12489688
1880:15689384
1785:–
1764:–
1739:Chloroma
1733:See also
1652:staining
1595:carbonyl
1588:isoforms
1540:The 150-
1493:bacteria
1473:tyrosine
1469:cofactor
1454:chloride
1432:Function
1344:proteins
1332:articles
1320:articles
1293:RCSB PDB
1203:1.11.2.2
1157:Wikidata
850:Sources:
690:lysosome
575:yolk sac
501:testicle
485:monocyte
3837:Biology
3791:Ligases
3561:Enzymes
3263:Heparin
2898:PDBe-KB
2888:UniProt
2867:9020887
2858:1218097
2839:. 321.
2405:3022070
2362:9553712
2353:1189459
2321:8718890
2258:6714564
2237:Bibcode
2200:2838938
2117:9787133
2082:8390491
1924:6192815
1787:Ensembl
1766:Ensembl
1700:myeloid
1670:plaques
1577:cystine
1362:) is a
1280:profile
1263:MetaCyc
983:UniProt
938:Ensembl
877:Species
856:QuickGO
710:nucleus
430:pattern
156:Aliases
3823:Portal
3765:Lyases
2893:P05164
2865:
2855:
2816:
2808:
2771:
2748:
2740:
2699:
2664:
2623:
2579:
2538:
2530:
2491:
2456:
2448:
2412:
2402:
2360:
2350:
2319:
2265:
2255:
2207:
2197:
2158:
2150:
2115:
2080:
2073:443356
2070:
1993:
1985:
1945:
1922:
1886:
1878:
1666:lesion
1479:as an
1452:) and
1418:sputum
1367:enzyme
1327:PubMed
1309:Search
1299:PDBsum
1239:ExPASy
1227:BRENDA
1215:IntEnz
1198:EC no.
1143:search
1141:PubMed
1016:P11247
997:P05164
893:Entrez
601:BioGPS
571:spleen
505:spleen
180:606989
3717:Types
3344:1.11)
2814:S2CID
2746:S2CID
2536:S2CID
2454:S2CID
2156:S2CID
2097:Blood
2026:(PDF)
2019:(PDF)
1991:S2CID
1884:S2CID
1727:Azide
1457:anion
1414:mucus
1275:PRIAM
926:17523
886:Mouse
881:Human
852:Amigo
513:blood
493:gonad
453:Mouse
446:Human
393:Start
328:Mouse
292:Start
288:17q22
225:Human
196:55450
188:97137
3809:list
3802:EC7
3796:list
3789:EC6
3783:list
3776:EC5
3770:list
3763:EC4
3757:list
3750:EC3
3744:list
3737:EC2
3731:list
3724:EC1
3166:(2°)
3116:(1°)
3057:1myp
3042:1mhl
3027:1dnw
3012:1dnu
2997:1d7w
2982:1d5l
2967:1d2v
2952:1cxp
2886:for
2863:PMID
2806:PMID
2769:ISBN
2738:PMID
2697:PMID
2662:PMID
2621:PMID
2577:PMID
2559:JAMA
2528:PMID
2489:PMID
2446:PMID
2410:PMID
2358:PMID
2317:PMID
2263:PMID
2205:PMID
2148:PMID
2113:PMID
2078:PMID
1983:PMID
1943:ISBN
1920:PMID
1876:PMID
1550:heme
1508:apoA
1416:and
1406:heme
1374:gene
1339:NCBI
1296:PDBe
1251:KEGG
907:4353
436:Bgee
384:Band
345:Chr.
283:Band
242:Chr.
176:OMIM
133:5FIW
129:4C1M
125:4EJX
121:4DL1
117:3ZS1
113:3ZS0
109:3F9P
105:1MYP
101:1MHL
97:1DNW
93:1DNU
89:1D7W
85:1D5L
81:1D2V
77:1CXP
58:RCSB
55:PDBe
3394:GPX
3104:of
2884:PDB
2853:PMC
2845:doi
2841:321
2798:doi
2728:doi
2724:349
2689:doi
2685:111
2652:doi
2611:doi
2567:doi
2563:286
2520:doi
2481:doi
2477:281
2438:doi
2400:PMC
2392:doi
2348:PMC
2309:doi
2253:PMC
2245:doi
2195:PMC
2187:doi
2140:doi
2136:218
2105:doi
2068:PMC
2060:doi
1975:doi
1971:104
1912:doi
1908:114
1866:doi
1562:MPO
1556:of
1542:kDa
1376:on
1371:MPO
1360:MPO
1315:PMC
1287:PDB
609:n/a
406:End
305:End
208:OMA
204:MPO
184:MGI
163:MPO
48:PDB
24:MPO
3849::
3342:EC
3336::
3289:,
2890::
2861:.
2851:.
2835:.
2812:.
2804:.
2794:10
2792:.
2744:.
2736:.
2722:.
2718:.
2695:.
2683:.
2660:.
2648:25
2646:.
2642:.
2619:.
2607:55
2605:.
2601:.
2589:^
2575:.
2561:.
2557:.
2534:.
2526:.
2516:27
2514:.
2510:.
2487:.
2475:.
2452:.
2444:.
2434:28
2432:.
2408:.
2398:.
2388:48
2386:.
2382:.
2370:^
2356:.
2344:62
2342:.
2338:.
2315:.
2305:35
2303:.
2290:^
2278:.
2261:.
2251:.
2243:.
2231:.
2227:.
2203:.
2193:.
2183:23
2181:.
2177:.
2154:.
2146:.
2134:.
2111:.
2101:92
2099:.
2076:.
2066:.
2056:91
2054:.
2050:.
2003:^
1989:.
1981:.
1969:.
1957:^
1918:.
1906:.
1882:.
1874:.
1862:77
1860:.
1856:.
1830:^
1820:.
1802:.
1773:^
1752:^
1628:.
1601:.
1499:.
1483:.
1444:(H
1424:.
854:/
412:bp
399:bp
311:bp
298:bp
206:;
202::
198:;
194::
190:;
186::
182:;
178::
131:,
127:,
123:,
119:,
115:,
111:,
107:,
103:,
99:,
95:,
91:,
87:,
83:,
79:,
3825::
3811:)
3807:(
3798:)
3794:(
3785:)
3781:(
3772:)
3768:(
3759:)
3755:(
3746:)
3742:(
3733:)
3729:(
3553:e
3546:t
3539:v
3519:6
3514:5
3509:4
3504:3
3499:2
3494:1
3487:)
3483:(
3432:8
3427:7
3422:6
3417:5
3412:4
3407:3
3402:2
3397:1
3340:(
3326:e
3319:t
3312:v
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3136:(
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3079:v
2927:e
2920:t
2913:v
2900:.
2869:.
2847::
2820:.
2800::
2777:.
2752:.
2730::
2703:.
2691::
2668:.
2654::
2627:.
2613::
2583:.
2569::
2542:.
2522::
2495:.
2483::
2460:.
2440::
2416:.
2394::
2364:.
2323:.
2311::
2282:.
2269:.
2247::
2239::
2233:5
2211:.
2189::
2162:.
2142::
2119:.
2107::
2084:.
2062::
2035:.
1997:.
1977::
1951:.
1926:.
1914::
1890:.
1868::
1841:.
1824:.
1806:.
1450:2
1448:O
1446:2
1358:(
330:)
227:)
210::
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