753:
3969:
804:(PKC) result in excessive inhibition of MYLP, which counteracts the activity of MYLK by dephosphorylating myosin light chain. Because myosin light chain has no inherent phosphate cleaving property over active PKC prevents the dephosphorylation of myosin light protein leaving it in the activated conformation, causing an increase in smooth muscle contraction.
487:
630:
of calcium ion to this domain increases the affinity of MYLK binding to myosin light chain. This myosin binding domain is located at the C-Terminus end of the kinase. On the other side of the kinase at the N-Terminus end, sits the actin-binding domain, which allows MYLK to form interactions with actin filaments, keeping it in place.
185:
728:
does, this mechanism is the main pathway for regulating smooth muscle contraction. Reducing intracellular calcium concentration inactivates MLCK but does not stop smooth muscle contraction since the myosin light chain has been physically modified through phosphorylation(and not via ATPase activity).
629:
While there are numerous differing domains depending on the cell type, there are several characteristic domains common amongst all MYLK isoforms. MYLK’s contain a catalytic core domain with an ATP binding domain. On either sides of the catalytic core sit calcium ion/calmodulin binding sites. Binding
748:
are involved in regulating
Calcium ion intake; these Calcium ions, in turn stimulate a MYLK, forcing a contraction. Rho kinase also modulates the activity of MYLK by downregulating the activity of MYLK's counterpart protein: Myosin Light Chain Phosphatase (MYLP). In addition to downregulation of
859:
Muniz, J.R.C.; Mahajan, P.; Rellos, P.; Fedorov, O.; Shrestha, B.; Wang, J.; Elkins, J.M.; Daga, N.; Cocking, R.; Chaikuad, A.; Krojer, T.; Ugochukwu, E.; Yue, W.; von Delft, F.; Arrowsmith, C.H.; Edwards, A.M.; Weigelt, J.; Bountra, C.; Gileadi, O.; Knapp, S. (2010).
785:. However, when the inward pulling force of the actin stress fiber becomes greater than the outward pulling force of the cell adhesion molecules due to an overactive MYLK, tissues can become slightly pulled apart and leaky, leading to passage of fluid into the lungs.
773:, in which fluid is able to pass into the alveoli. Within the cells, MYLK provides an inward pulling force, phosphorylating myosin light chain causing a contraction of the myosin/actin stress fiber complex. Conversely, cell-cell adhesion via tight and
1671:
Seguchi O, Takashima S, Yamazaki S, Asakura M, Asano Y, Shintani Y, Wakeno M, Minamino T, Kondo H, Furukawa H, Nakamaru K, Naito A, Takahashi T, Ohtsuka T, Kawakami K, Isomura T, Kitamura S, Tomoike H, Mochizuki N, Kitakaze M (October 2007).
749:
MYLK, ROCK indirectly strengthens actin/myosin contraction through inhibiting
Cofilin, a protein which depolymerizes actin stress fibers. Similar to ROCK, Protein Kinase C regulates MYLK via the CPI-17 protein, which downregulates MYLP.
729:
To stop smooth muscle contraction this change needs to be reversed. Dephosphorylation of the myosin light chain (and subsequent termination of muscle contraction) occurs through activity of a second enzyme known as
1832:
2117:
781:(ECM) via integrins and focal adhesion proteins results in an outward pulling force. Myosin light chain pulls the actin stress fiber attached to the cadherin, resisting the force of the adjacent cell's
765:
Some pulmonary disorders have been found to arise due to an inability of MYLK to function properly in lung cells. Over-activity in MYLK creates an imbalance in mechanical forces between adjacent
1594:
Kim MT, Kim BJ, Lee JH, Kwon SC, Yeon DS, Yang DK, So I, Kim KW (April 2006). "Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells".
1825:
887:
Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kohama K (June 2001). "Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction".
1818:
2025:
1463:"Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression"
512:
361:
219:
45:
2573:
3412:
1876:
3521:
2259:
2146:
1800:
697:
2534:
3507:
2972:
1863:
1845:
606:
3609:
3490:
1723:
3196:
2065:
1253:
Ringvold HC, Khalil RA (2017). "Protein Kinase C as
Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders".
3999:
3994:
3260:
2235:
1678:
1270:
1099:
1074:
3989:
3516:
2050:
1420:
770:
385:
243:
69:
752:
3573:
3248:
3688:
2505:
2495:
2180:
1467:
1416:"A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability"
3187:
930:
Khapchaev AY, Shirinsky VP (December 2016). "Myosin Light Chain Kinase MYLK1: Anatomy, Interactions, Functions, and
Regulation".
524:
373:
231:
57:
517:
3456:
3128:
2490:
2481:
366:
224:
1014:
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (December 2002). "The protein kinase complement of the human genome".
862:"RCSB Protein Data Bank - Structure Summary for 2X4F - The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156"
50:
1551:"Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells"
730:
3844:
700:(a protein kinase) causes a conformational change in MYLK, activating it and resulting in an increase in phosphorylation of
2871:
2368:
2359:
2016:
1962:
745:
3959:
2059:
1508:"Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure"
1549:
Shimizu S, Yoshida T, Wakamori M, Ishii M, Okada T, Takahashi M, Seto M, Sakurada K, Kiuchi Y, Mori Y (January 2006).
1810:
3083:
2901:
2397:
1306:"Epigenetic contribution of the myosin light chain kinase gene to the risk for acute respiratory distress syndrome"
3829:
3945:
3932:
3919:
3906:
3893:
3880:
3867:
3073:
3068:
3063:
3053:
3048:
3043:
3033:
2199:
1555:
1414:
Clayburgh DR, Rosen S, Witkowski ED, Wang F, Blair S, Dudek S, Garcia JG, Alverdy JC, Turner JR (December 2004).
3839:
3793:
3736:
3296:
3287:
3238:
2004:
1849:
1791:
1781:
110:
1624:
3741:
3596:
3019:
1632:
797:
1065:
Robinson A, Colbran R (2013). "Calcium/Calmodulin-Dependent
Protein Kinases". In Lennarz W, Lane D (eds.).
685:
529:
378:
236:
62:
3762:
3681:
2295:
778:
431:
289:
3834:
2862:
1787:
1366:
1023:
834:"RCSB Protein Data Bank - Structure Summary for 3KF9 - Crystal structure of the SdCen/skMLCK complex"
832:
Radu, L.; Assairi, L.; Blouquit, Y.; Durand, D.; Miron, S.; Charbonnier, J.B.; Craescu, C.T. (2011).
127:
1506:
Russo JM, Florian P, Shen L, Graham WV, Tretiakova MS, Gitter AH, Mrsny RJ, Turner JR (April 2005).
3798:
689:
3370:
1207:
Dudek SM, Garcia JG (October 2001). "Cytoskeletal regulation of pulmonary vascular permeability".
4004:
3731:
3473:
3427:
1777:
1659:
1232:
1140:
1047:
955:
912:
789:
681:
614:
861:
833:
2733:
2442:
1758:
1740:
1705:
1651:
1611:
1582:
1537:
1494:
1449:
1392:
1335:
1286:
1266:
1224:
1189:
1132:
1095:
1070:
1039:
996:
947:
904:
774:
293:
3777:
3772:
3746:
3674:
3326:
2568:
2558:
2553:
2471:
2462:
2392:
2383:
2329:
2320:
1977:
1748:
1732:
1695:
1687:
1641:
1603:
1572:
1564:
1527:
1519:
1484:
1476:
1439:
1429:
1382:
1374:
1325:
1317:
1276:
1258:
1216:
1179:
1171:
1124:
1031:
986:
939:
896:
869:
841:
813:
801:
741:
435:
426:
284:
122:
115:
3824:
3808:
3721:
3152:
2223:
2218:
2213:
1674:"A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart"
725:
572:
455:
313:
151:
131:
1370:
1027:
3973:
3862:
3803:
1753:
1718:
1700:
1673:
1577:
1550:
1532:
1507:
1489:
1462:
1444:
1415:
1387:
1354:
1330:
1305:
1281:
1184:
1159:
1115:
Anjum I (January 2018). "Calcium sensitization mechanisms in detrusor smooth muscles".
991:
974:
713:
1625:"Myosin light chain kinase plays a role in the regulation of epithelial cell survival"
1480:
1355:"Myosin Light Chain Kinase: Pulling the Strings of Epithelial Tight Junction Function"
3983:
3767:
3726:
2276:
2208:
1804:
1378:
1304:
Szilágyi KL, Liu C, Zhang X, Wang T, Fortman JD, Zhang W, Garcia JG (February 2017).
610:
1663:
1144:
1051:
959:
916:
541:
3716:
3147:
1972:
1236:
793:
692:, contraction of smooth muscle fibres may begin. First, the calcium will bind to
1568:
1523:
1220:
402:
260:
86:
3940:
3875:
3711:
3353:
2985:
2925:
2808:
2728:
2452:
1461:
Wang F, Graham WV, Wang Y, Witkowski ED, Schwarz BT, Turner JR (February 2005).
1262:
766:
717:
709:
582:
465:
323:
191:
161:
3968:
1607:
1321:
900:
3441:
1915:
1736:
943:
693:
548:
409:
267:
93:
1744:
1717:
Hong F, Haldeman BD, Jackson D, Carter M, Baker JE, Cremo CR (15 June 2011).
3914:
3888:
2402:
1128:
1035:
618:
1762:
1709:
1655:
1615:
1586:
1541:
1498:
1453:
1434:
1396:
1339:
1290:
1228:
1193:
1136:
1043:
951:
908:
1000:
873:
845:
2758:
2653:
2648:
2643:
782:
721:
553:
414:
272:
98:
1160:"Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity"
3417:
3395:
3390:
3380:
3375:
3177:
3172:
3167:
3162:
3157:
3142:
3137:
2788:
2753:
1992:
1987:
1982:
673:
491:
The
Crystal Structure of the Human Myosin Light Chain Kinase Loc340156.
195:
1646:
3927:
3697:
3647:
3642:
3637:
3632:
3627:
3622:
3617:
3568:
3563:
3558:
3553:
3548:
3531:
3526:
3400:
3385:
3336:
3331:
3316:
3311:
3306:
3301:
3275:
3270:
3265:
3253:
3231:
3226:
3118:
3093:
2768:
2593:
2588:
2583:
2578:
2563:
2407:
2344:
2339:
2334:
2310:
2136:
2131:
2105:
2100:
2095:
2085:
2080:
2070:
1910:
1841:
1691:
1175:
975:"Myosin Light Chain Kinase: Functional Domains and Structural Motifs"
705:
701:
677:
536:
397:
255:
81:
486:
3901:
3543:
3536:
3446:
3343:
3243:
3221:
3216:
3211:
3206:
3201:
3113:
3108:
3103:
3098:
3088:
3058:
3038:
2915:
2910:
2891:
2886:
2876:
2852:
2847:
2842:
2818:
2813:
2803:
2798:
2793:
2783:
2763:
2748:
2743:
2738:
2718:
2713:
2703:
2698:
2693:
2688:
2683:
2673:
2668:
2663:
2658:
2638:
2633:
2628:
2623:
2618:
2613:
2598:
2548:
2543:
2437:
2432:
2427:
2422:
2417:
2412:
2373:
2305:
2300:
2249:
2244:
2170:
2165:
2160:
2126:
2118:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
1920:
1905:
1900:
1895:
1890:
1885:
973:
Stull JT, Lin PJ, Krueger JK, Trewhella J, Zhi G (December 1998).
751:
696:. After the influx of calcium ions and the binding to calmodulin,
660:
654:
648:
505:
354:
338:
212:
184:
176:
3436:
3363:
3358:
3348:
3321:
3078:
3028:
3009:
3004:
2999:
2994:
2949:
2944:
2939:
2934:
2881:
2837:
2778:
2773:
2723:
2708:
2678:
2608:
2524:
2519:
2514:
2447:
2349:
2290:
2285:
2189:
2155:
2040:
2035:
2030:
1999:
1967:
1955:
1950:
1945:
1935:
1930:
642:
390:
248:
74:
38:
22:
3670:
3594:
2970:
1861:
1814:
3405:
1940:
1925:
708:
residue 19. The phosphorylation of MLC will enable the myosin
1257:. Advances in Pharmacology. Vol. 78. pp. 203–301.
3666:
1719:"Biochemistry of Smooth Muscle Myosin Light Chain Kinase"
1117:
Journal of Basic and
Clinical Physiology and Pharmacology
3957:
3853:
3817:
3786:
3755:
3704:
3608:
3506:
3489:
3472:
3455:
3426:
3286:
3186:
3127:
3018:
2984:
2924:
2900:
2861:
2827:
2533:
2504:
2480:
2461:
2382:
2358:
2319:
2275:
2258:
2234:
2198:
2179:
2145:
2116:
2049:
2015:
1875:
578:
568:
563:
547:
535:
523:
511:
501:
496:
479:
461:
451:
446:
425:
420:
408:
396:
384:
372:
360:
350:
345:
337:
319:
309:
304:
283:
278:
266:
254:
242:
230:
218:
208:
203:
198:/ human skeletal muscle myosin light-chain complex.
175:
157:
147:
142:
121:
109:
104:
92:
80:
68:
56:
44:
34:
29:
21:
1158:Amano M, Nakayama M, Kaibuchi K (September 2010).
769:and lung tissue cells. An imbalance may result in
676:are important in the mechanism of contraction in
1094:(2nd ed.). Elsevier inc. pp. 351–361.
1069:(2nd ed.). Elsevier inc. pp. 304–309.
1596:American Journal of Physiology. Cell Physiology
1248:
1246:
788:Another source of smooth muscle disorders like
684:cations (Ca) into the muscle, either from the
3682:
1877:Non-specific serine/threonine protein kinases
1826:
8:
716:and allow contraction to begin (through the
177:myosin light-chain kinase 2, skeletal muscle
3689:
3675:
3667:
3605:
3591:
2981:
2967:
2260:Goodpasture-antigen-binding protein kinase
1872:
1858:
1833:
1819:
1811:
1801:United States National Library of Medicine
1359:Annals of the New York Academy of Sciences
720:). Since smooth muscle does not contain a
560:
485:
443:
301:
183:
139:
2973:Serine/threonine-specific protein kinases
2147:(isocitrate dehydrogenase (NADP+)) kinase
1864:Serine/threonine-specific protein kinases
1846:Serine/threonine-specific protein kinases
1790:at the U.S. National Library of Medicine
1780:at the U.S. National Library of Medicine
1752:
1699:
1645:
1576:
1531:
1488:
1443:
1433:
1386:
1329:
1280:
1183:
990:
756:Structural Diagram and Regulation of MYLK
3508:Receptor protein serine/threonine kinase
1799:This article incorporates text from the
617:, namely, the regulatory light chain of
607:serine/threonine-specific protein kinase
3964:
3491:Low-density-lipoprotein receptor kinase
1724:Archives of Biochemistry and Biophysics
824:
1353:Cunningham KE, Turner JR (July 2012).
476:
334:
172:
18:
2236:Fas-activated serine/threonine kinase
1679:The Journal of Clinical Investigation
1255:Vascular Pharmacology - Smooth Muscle
7:
3517:Bone morphogenetic protein receptors
1623:Connell LE, Helfman DM (June 2006).
1067:Encyclopedia of Biological Chemistry
638:Four different MYLK isoforms exist:
2051:Dephospho-(reductase kinase) kinase
1421:The Journal of Biological Chemistry
771:acute respiratory distress syndrome
2506:G-protein coupled receptor kinases
992:10.1111/j.1365-201X.1998.tb10699.x
14:
2496:Beta adrenergic receptor kinase-2
2181:(tyrosine 3-monooxygenase) kinase
1468:The American Journal of Pathology
1090:Feher J (2017). "Smooth Muscle".
3967:
3188:Mitogen-activated protein kinase
1379:10.1111/j.1749-6632.2012.06526.x
761:Mutations and resulting diseases
3574:Anti-MĂĽllerian hormone receptor
3457:(acetyl-CoA carboxylase) kinase
3129:(RNA-polymerase)-subunit kinase
2491:Beta adrenergic receptor kinase
2482:Beta adrenergic receptor kinase
480:Human Myosin Light-Chain Kinase
3197:Extracellular signal-regulated
731:myosin light-chain phosphatase
1:
3261:P38 mitogen-activated protein
2360:cGMP-dependent protein kinase
2321:cAMP-dependent protein kinase
2017:Pyruvate dehydrogenase kinase
1963:Ataxia telangiectasia mutated
1481:10.1016/S0002-9440(10)62264-X
1209:Journal of Applied Physiology
1092:Quantitative Human Physiology
680:. Once there is an influx of
4000:Genes on human chromosome 16
3995:Genes on human chromosome 20
2060:AMP-activated protein kinase
1569:10.1113/jphysiol.2005.097998
1524:10.1053/j.gastro.2005.01.004
1221:10.1152/jappl.2001.91.4.1487
3990:Genes on human chromosome 3
2975:(EC 2.7.11.21-EC 2.7.11.30)
1263:10.1016/bs.apha.2016.06.002
866:Worldwide Protein Data Bank
838:Worldwide Protein Data Bank
625:General structural features
339:myosin light-chain kinase 3
4021:
2902:Elongation factor 2 kinase
1866:(EC 2.7.11.1-EC 2.7.11.20)
1608:10.1152/ajpcell.00602.2004
1322:10.1016/j.trsl.2016.07.020
901:10.1080/152165401753366087
777:, along with anchoring to
3845:Michaelis–Menten kinetics
3604:
3590:
3297:MAP kinase kinase kinases
2980:
2966:
2829:Myosin light-chain kinase
2535:Ca2+/calmodulin-dependent
2200:Myosin-heavy-chain kinase
1871:
1857:
1788:Myosin-Light-Chain+Kinase
1737:10.1016/j.abb.2011.04.018
1556:The Journal of Physiology
944:10.1134/S000629791613006X
595:Myosin light-chain kinase
559:
484:
442:
300:
189:Crystal structure of the
182:
138:
23:Myosin Light-Chain kinase
3737:Diffusion-limited enzyme
3597:Dual-specificity kinases
1792:Medical Subject Headings
1782:Medical Subject Headings
932:Biochemistry. Biokhimiia
800:arise when mutations to
3020:Cyclin-dependent kinase
1633:Journal of Cell Science
1129:10.1515/jbcpp-2017-0071
1036:10.1126/science.1075762
798:coronary artery disease
16:Class of kinase enzymes
1435:10.1074/jbc.M408822200
1310:Translational Research
757:
686:sarcoplasmic reticulum
3830:Eadie–Hofstee diagram
3763:Allosteric regulation
779:extra cellular matrix
755:
3840:Lineweaver–Burk plot
2863:Phosphorylase kinase
790:ischemia–reperfusion
1778:MYLK+protein,+human
1371:2012NYASA1258...34C
1028:2002Sci...298.1912M
874:10.2210/pdb2x4f/pdb
846:10.2210/pdb3kf9/pdb
737:Upstream Regulators
690:extracellular space
3799:Enzyme superfamily
3732:Enzyme promiscuity
3474:Tropomyosin kinase
3428:Tau-protein kinase
1803:, which is in the
1640:(Pt 11): 2269–81.
775:adherens junctions
758:
702:myosin light chain
615:myosin light chain
3955:
3954:
3664:
3663:
3660:
3659:
3656:
3655:
3586:
3585:
3582:
3581:
2962:
2961:
2958:
2957:
2443:Protein kinase N1
2398:Protein kinase Cζ
1647:10.1242/jcs.02926
1272:978-0-12-811485-8
1101:978-0-12-800883-6
1076:978-0-12-378631-9
1022:(5600): 1912–34.
979:Acta Physiologica
938:(13): 1676–1697.
718:crossbridge cycle
592:
591:
588:
587:
475:
474:
471:
470:
333:
332:
329:
328:
171:
170:
167:
166:
4012:
3972:
3971:
3963:
3835:Hanes–Woolf plot
3778:Enzyme activator
3773:Enzyme inhibitor
3747:Enzyme catalysis
3691:
3684:
3677:
3668:
3606:
3592:
3239:C-Jun N-terminal
2982:
2968:
2472:Rhodopsin kinase
2463:Rhodopsin kinase
2393:Protein kinase C
2384:Protein kinase C
2369:Protein kinase G
2330:Protein kinase A
1941:Protein kinase B
1873:
1859:
1835:
1828:
1821:
1812:
1766:
1756:
1713:
1703:
1692:10.1172/JCI30804
1667:
1649:
1629:
1619:
1590:
1580:
1563:(Pt 2): 219–35.
1545:
1535:
1512:Gastroenterology
1502:
1492:
1457:
1447:
1437:
1428:(53): 55506–13.
1401:
1400:
1390:
1350:
1344:
1343:
1333:
1301:
1295:
1294:
1284:
1250:
1241:
1240:
1204:
1198:
1197:
1187:
1176:10.1002/cm.20472
1155:
1149:
1148:
1112:
1106:
1105:
1087:
1081:
1080:
1062:
1056:
1055:
1011:
1005:
1004:
994:
970:
964:
963:
927:
921:
920:
884:
878:
877:
856:
850:
849:
829:
814:protein kinase A
802:protein kinase C
742:Protein kinase C
561:
489:
477:
444:
335:
302:
187:
173:
140:
19:
4020:
4019:
4015:
4014:
4013:
4011:
4010:
4009:
3980:
3979:
3978:
3966:
3958:
3956:
3951:
3863:Oxidoreductases
3849:
3825:Enzyme kinetics
3813:
3809:List of enzymes
3782:
3751:
3722:Catalytic triad
3700:
3695:
3665:
3652:
3600:
3578:
3502:
3485:
3468:
3451:
3422:
3282:
3182:
3153:P70-S6 Kinase 1
3123:
3014:
2976:
2954:
2920:
2896:
2857:
2823:
2529:
2500:
2476:
2457:
2378:
2354:
2315:
2271:
2254:
2230:
2224:Aurora C kinase
2219:Aurora B kinase
2214:Aurora A kinase
2194:
2175:
2141:
2112:
2045:
2011:
1867:
1853:
1839:
1774:
1769:
1716:
1686:(10): 2812–24.
1670:
1627:
1622:
1593:
1548:
1518:(4): 987–1001.
1505:
1460:
1413:
1409:
1407:Further reading
1404:
1352:
1351:
1347:
1303:
1302:
1298:
1273:
1252:
1251:
1244:
1215:(4): 1487–500.
1206:
1205:
1201:
1157:
1156:
1152:
1114:
1113:
1109:
1102:
1089:
1088:
1084:
1077:
1064:
1063:
1059:
1013:
1012:
1008:
972:
971:
967:
929:
928:
924:
886:
885:
881:
858:
857:
853:
831:
830:
826:
822:
810:
763:
739:
726:striated muscle
712:to bind to the
670:
645:– smooth muscle
636:
627:
492:
199:
25:, smooth muscle
17:
12:
11:
5:
4018:
4016:
4008:
4007:
4002:
3997:
3992:
3982:
3981:
3977:
3976:
3953:
3952:
3950:
3949:
3936:
3923:
3910:
3897:
3884:
3871:
3857:
3855:
3851:
3850:
3848:
3847:
3842:
3837:
3832:
3827:
3821:
3819:
3815:
3814:
3812:
3811:
3806:
3801:
3796:
3790:
3788:
3787:Classification
3784:
3783:
3781:
3780:
3775:
3770:
3765:
3759:
3757:
3753:
3752:
3750:
3749:
3744:
3739:
3734:
3729:
3724:
3719:
3714:
3708:
3706:
3702:
3701:
3696:
3694:
3693:
3686:
3679:
3671:
3662:
3661:
3658:
3657:
3654:
3653:
3651:
3650:
3645:
3640:
3635:
3630:
3625:
3620:
3614:
3612:
3602:
3601:
3595:
3588:
3587:
3584:
3583:
3580:
3579:
3577:
3576:
3571:
3566:
3561:
3556:
3551:
3546:
3541:
3540:
3539:
3534:
3529:
3524:
3513:
3511:
3510:(EC 2.7.11.30)
3504:
3503:
3501:
3500:
3496:
3494:
3493:(EC 2.7.11.29)
3487:
3486:
3484:
3483:
3479:
3477:
3476:(EC 2.7.11.28)
3470:
3469:
3467:
3466:
3462:
3460:
3459:(EC 2.7.11.27)
3453:
3452:
3450:
3449:
3444:
3439:
3433:
3431:
3430:(EC 2.7.11.26)
3424:
3423:
3421:
3420:
3415:
3410:
3409:
3408:
3403:
3398:
3393:
3388:
3383:
3378:
3368:
3367:
3366:
3361:
3356:
3351:
3341:
3340:
3339:
3334:
3329:
3324:
3319:
3314:
3309:
3304:
3293:
3291:
3290:(EC 2.7.11.25)
3284:
3283:
3281:
3280:
3279:
3278:
3273:
3268:
3258:
3257:
3256:
3251:
3246:
3236:
3235:
3234:
3229:
3224:
3219:
3214:
3209:
3204:
3193:
3191:
3190:(EC 2.7.11.24)
3184:
3183:
3181:
3180:
3175:
3170:
3165:
3160:
3155:
3150:
3145:
3140:
3134:
3132:
3131:(EC 2.7.11.23)
3125:
3124:
3122:
3121:
3116:
3111:
3106:
3101:
3096:
3091:
3086:
3081:
3076:
3071:
3066:
3061:
3056:
3051:
3046:
3041:
3036:
3031:
3025:
3023:
3022:(EC 2.7.11.22)
3016:
3015:
3013:
3012:
3007:
3002:
2997:
2991:
2989:
2988:(EC 2.7.11.21)
2978:
2977:
2971:
2964:
2963:
2960:
2959:
2956:
2955:
2953:
2952:
2947:
2942:
2937:
2931:
2929:
2928:(EC 2.7.11.21)
2922:
2921:
2919:
2918:
2913:
2907:
2905:
2904:(EC 2.7.11.20)
2898:
2897:
2895:
2894:
2889:
2884:
2879:
2874:
2868:
2866:
2865:(EC 2.7.11.19)
2859:
2858:
2856:
2855:
2850:
2845:
2840:
2834:
2832:
2831:(EC 2.7.11.18)
2825:
2824:
2822:
2821:
2816:
2811:
2806:
2801:
2796:
2791:
2786:
2781:
2776:
2771:
2766:
2761:
2756:
2751:
2746:
2741:
2736:
2731:
2726:
2721:
2716:
2711:
2706:
2701:
2696:
2691:
2686:
2681:
2676:
2671:
2666:
2661:
2656:
2651:
2646:
2641:
2636:
2631:
2626:
2621:
2616:
2611:
2606:
2601:
2596:
2591:
2586:
2581:
2576:
2571:
2566:
2561:
2556:
2551:
2546:
2540:
2538:
2537:(EC 2.7.11.17)
2531:
2530:
2528:
2527:
2522:
2517:
2511:
2509:
2508:(EC 2.7.11.16)
2502:
2501:
2499:
2498:
2493:
2487:
2485:
2484:(EC 2.7.11.15)
2478:
2477:
2475:
2474:
2468:
2466:
2465:(EC 2.7.11.14)
2459:
2458:
2456:
2455:
2450:
2445:
2440:
2435:
2430:
2425:
2420:
2415:
2410:
2405:
2400:
2395:
2389:
2387:
2386:(EC 2.7.11.13)
2380:
2379:
2377:
2376:
2371:
2365:
2363:
2362:(EC 2.7.11.12)
2356:
2355:
2353:
2352:
2347:
2342:
2337:
2332:
2326:
2324:
2323:(EC 2.7.11.11)
2317:
2316:
2314:
2313:
2308:
2303:
2298:
2293:
2288:
2282:
2280:
2279:(EC 2.7.11.10)
2273:
2272:
2270:
2269:
2265:
2263:
2256:
2255:
2253:
2252:
2247:
2241:
2239:
2232:
2231:
2229:
2228:
2227:
2226:
2221:
2216:
2205:
2203:
2196:
2195:
2193:
2192:
2186:
2184:
2177:
2176:
2174:
2173:
2168:
2163:
2158:
2152:
2150:
2143:
2142:
2140:
2139:
2134:
2129:
2123:
2121:
2114:
2113:
2111:
2110:
2109:
2108:
2103:
2098:
2090:
2089:
2088:
2083:
2075:
2074:
2073:
2068:
2056:
2054:
2047:
2046:
2044:
2043:
2038:
2033:
2028:
2022:
2020:
2013:
2012:
2010:
2009:
2008:
2007:
1997:
1996:
1995:
1990:
1985:
1980:
1970:
1965:
1960:
1959:
1958:
1953:
1948:
1938:
1933:
1928:
1923:
1918:
1913:
1908:
1903:
1898:
1893:
1888:
1882:
1880:
1869:
1868:
1862:
1855:
1854:
1840:
1838:
1837:
1830:
1823:
1815:
1796:
1795:
1785:
1773:
1772:External links
1770:
1768:
1767:
1731:(2): 135–146.
1714:
1668:
1620:
1602:(4): 1031–40.
1591:
1546:
1503:
1458:
1410:
1408:
1405:
1403:
1402:
1345:
1296:
1271:
1242:
1199:
1150:
1123:(3): 227–235.
1107:
1100:
1082:
1075:
1057:
1006:
985:(4): 471–482.
965:
922:
879:
851:
823:
821:
818:
817:
816:
809:
806:
762:
759:
738:
735:
714:actin filament
669:
666:
665:
664:
658:
652:
646:
635:
632:
626:
623:
611:phosphorylates
597:also known as
590:
589:
586:
585:
580:
576:
575:
570:
566:
565:
557:
556:
551:
545:
544:
539:
533:
532:
527:
521:
520:
515:
509:
508:
503:
499:
498:
494:
493:
490:
482:
481:
473:
472:
469:
468:
463:
459:
458:
453:
449:
448:
440:
439:
429:
423:
422:
418:
417:
412:
406:
405:
400:
394:
393:
388:
382:
381:
376:
370:
369:
364:
358:
357:
352:
348:
347:
343:
342:
331:
330:
327:
326:
321:
317:
316:
311:
307:
306:
298:
297:
287:
281:
280:
276:
275:
270:
264:
263:
258:
252:
251:
246:
240:
239:
234:
228:
227:
222:
216:
215:
210:
206:
205:
201:
200:
188:
180:
179:
169:
168:
165:
164:
159:
155:
154:
149:
145:
144:
136:
135:
125:
119:
118:
113:
107:
106:
102:
101:
96:
90:
89:
84:
78:
77:
72:
66:
65:
60:
54:
53:
48:
42:
41:
36:
32:
31:
27:
26:
15:
13:
10:
9:
6:
4:
3:
2:
4017:
4006:
4003:
4001:
3998:
3996:
3993:
3991:
3988:
3987:
3985:
3975:
3970:
3965:
3961:
3947:
3943:
3942:
3937:
3934:
3930:
3929:
3924:
3921:
3917:
3916:
3911:
3908:
3904:
3903:
3898:
3895:
3891:
3890:
3885:
3882:
3878:
3877:
3872:
3869:
3865:
3864:
3859:
3858:
3856:
3852:
3846:
3843:
3841:
3838:
3836:
3833:
3831:
3828:
3826:
3823:
3822:
3820:
3816:
3810:
3807:
3805:
3804:Enzyme family
3802:
3800:
3797:
3795:
3792:
3791:
3789:
3785:
3779:
3776:
3774:
3771:
3769:
3768:Cooperativity
3766:
3764:
3761:
3760:
3758:
3754:
3748:
3745:
3743:
3740:
3738:
3735:
3733:
3730:
3728:
3727:Oxyanion hole
3725:
3723:
3720:
3718:
3715:
3713:
3710:
3709:
3707:
3703:
3699:
3692:
3687:
3685:
3680:
3678:
3673:
3672:
3669:
3649:
3646:
3644:
3641:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3615:
3613:
3611:
3607:
3603:
3598:
3593:
3589:
3575:
3572:
3570:
3567:
3565:
3562:
3560:
3557:
3555:
3552:
3550:
3547:
3545:
3542:
3538:
3535:
3533:
3530:
3528:
3525:
3523:
3520:
3519:
3518:
3515:
3514:
3512:
3509:
3505:
3498:
3497:
3495:
3492:
3488:
3481:
3480:
3478:
3475:
3471:
3464:
3463:
3461:
3458:
3454:
3448:
3445:
3443:
3440:
3438:
3435:
3434:
3432:
3429:
3425:
3419:
3416:
3414:
3411:
3407:
3404:
3402:
3399:
3397:
3394:
3392:
3389:
3387:
3384:
3382:
3379:
3377:
3374:
3373:
3372:
3369:
3365:
3362:
3360:
3357:
3355:
3352:
3350:
3347:
3346:
3345:
3342:
3338:
3335:
3333:
3330:
3328:
3325:
3323:
3320:
3318:
3315:
3313:
3310:
3308:
3305:
3303:
3300:
3299:
3298:
3295:
3294:
3292:
3289:
3285:
3277:
3274:
3272:
3269:
3267:
3264:
3263:
3262:
3259:
3255:
3252:
3250:
3247:
3245:
3242:
3241:
3240:
3237:
3233:
3230:
3228:
3225:
3223:
3220:
3218:
3215:
3213:
3210:
3208:
3205:
3203:
3200:
3199:
3198:
3195:
3194:
3192:
3189:
3185:
3179:
3176:
3174:
3171:
3169:
3166:
3164:
3161:
3159:
3156:
3154:
3151:
3149:
3146:
3144:
3141:
3139:
3136:
3135:
3133:
3130:
3126:
3120:
3117:
3115:
3112:
3110:
3107:
3105:
3102:
3100:
3097:
3095:
3092:
3090:
3087:
3085:
3082:
3080:
3077:
3075:
3072:
3070:
3067:
3065:
3062:
3060:
3057:
3055:
3052:
3050:
3047:
3045:
3042:
3040:
3037:
3035:
3032:
3030:
3027:
3026:
3024:
3021:
3017:
3011:
3008:
3006:
3003:
3001:
2998:
2996:
2993:
2992:
2990:
2987:
2983:
2979:
2974:
2969:
2965:
2951:
2948:
2946:
2943:
2941:
2938:
2936:
2933:
2932:
2930:
2927:
2923:
2917:
2914:
2912:
2909:
2908:
2906:
2903:
2899:
2893:
2890:
2888:
2885:
2883:
2880:
2878:
2875:
2873:
2870:
2869:
2867:
2864:
2860:
2854:
2851:
2849:
2846:
2844:
2841:
2839:
2836:
2835:
2833:
2830:
2826:
2820:
2817:
2815:
2812:
2810:
2807:
2805:
2802:
2800:
2797:
2795:
2792:
2790:
2787:
2785:
2782:
2780:
2777:
2775:
2772:
2770:
2767:
2765:
2762:
2760:
2757:
2755:
2752:
2750:
2747:
2745:
2742:
2740:
2737:
2735:
2732:
2730:
2727:
2725:
2722:
2720:
2717:
2715:
2712:
2710:
2707:
2705:
2702:
2700:
2697:
2695:
2692:
2690:
2687:
2685:
2682:
2680:
2677:
2675:
2672:
2670:
2667:
2665:
2662:
2660:
2657:
2655:
2652:
2650:
2647:
2645:
2642:
2640:
2637:
2635:
2632:
2630:
2627:
2625:
2622:
2620:
2617:
2615:
2612:
2610:
2607:
2605:
2602:
2600:
2597:
2595:
2592:
2590:
2587:
2585:
2582:
2580:
2577:
2575:
2572:
2570:
2567:
2565:
2562:
2560:
2557:
2555:
2552:
2550:
2547:
2545:
2542:
2541:
2539:
2536:
2532:
2526:
2523:
2521:
2518:
2516:
2513:
2512:
2510:
2507:
2503:
2497:
2494:
2492:
2489:
2488:
2486:
2483:
2479:
2473:
2470:
2469:
2467:
2464:
2460:
2454:
2451:
2449:
2446:
2444:
2441:
2439:
2436:
2434:
2431:
2429:
2426:
2424:
2421:
2419:
2416:
2414:
2411:
2409:
2406:
2404:
2401:
2399:
2396:
2394:
2391:
2390:
2388:
2385:
2381:
2375:
2372:
2370:
2367:
2366:
2364:
2361:
2357:
2351:
2348:
2346:
2343:
2341:
2338:
2336:
2333:
2331:
2328:
2327:
2325:
2322:
2318:
2312:
2309:
2307:
2304:
2302:
2299:
2297:
2294:
2292:
2289:
2287:
2284:
2283:
2281:
2278:
2274:
2267:
2266:
2264:
2262:(EC 2.7.11.9)
2261:
2257:
2251:
2248:
2246:
2243:
2242:
2240:
2238:(EC 2.7.11.8)
2237:
2233:
2225:
2222:
2220:
2217:
2215:
2212:
2211:
2210:
2209:Aurora kinase
2207:
2206:
2204:
2202:(EC 2.7.11.7)
2201:
2197:
2191:
2188:
2187:
2185:
2183:(EC 2.7.11.6)
2182:
2178:
2172:
2169:
2167:
2164:
2162:
2159:
2157:
2154:
2153:
2151:
2149:(EC 2.7.11.5)
2148:
2144:
2138:
2135:
2133:
2130:
2128:
2125:
2124:
2122:
2120:(EC 2.7.11.4)
2119:
2115:
2107:
2104:
2102:
2099:
2097:
2094:
2093:
2091:
2087:
2084:
2082:
2079:
2078:
2076:
2072:
2069:
2067:
2064:
2063:
2061:
2058:
2057:
2055:
2053:(EC 2.7.11.3)
2052:
2048:
2042:
2039:
2037:
2034:
2032:
2029:
2027:
2024:
2023:
2021:
2019:(EC 2.7.11.2)
2018:
2014:
2006:
2003:
2002:
2001:
1998:
1994:
1991:
1989:
1986:
1984:
1981:
1979:
1976:
1975:
1974:
1973:EIF-2 kinases
1971:
1969:
1966:
1964:
1961:
1957:
1954:
1952:
1949:
1947:
1944:
1943:
1942:
1939:
1937:
1934:
1932:
1929:
1927:
1924:
1922:
1919:
1917:
1914:
1912:
1909:
1907:
1904:
1902:
1899:
1897:
1894:
1892:
1889:
1887:
1884:
1883:
1881:
1879:(EC 2.7.11.1)
1878:
1874:
1870:
1865:
1860:
1856:
1851:
1847:
1843:
1836:
1831:
1829:
1824:
1822:
1817:
1816:
1813:
1809:
1808:
1806:
1805:public domain
1802:
1793:
1789:
1786:
1783:
1779:
1776:
1775:
1771:
1764:
1760:
1755:
1750:
1746:
1742:
1738:
1734:
1730:
1726:
1725:
1720:
1715:
1711:
1707:
1702:
1697:
1693:
1689:
1685:
1681:
1680:
1675:
1669:
1665:
1661:
1657:
1653:
1648:
1643:
1639:
1635:
1634:
1626:
1621:
1617:
1613:
1609:
1605:
1601:
1597:
1592:
1588:
1584:
1579:
1574:
1570:
1566:
1562:
1558:
1557:
1552:
1547:
1543:
1539:
1534:
1529:
1525:
1521:
1517:
1513:
1509:
1504:
1500:
1496:
1491:
1486:
1482:
1478:
1475:(2): 409–19.
1474:
1470:
1469:
1464:
1459:
1455:
1451:
1446:
1441:
1436:
1431:
1427:
1423:
1422:
1417:
1412:
1411:
1406:
1398:
1394:
1389:
1384:
1380:
1376:
1372:
1368:
1364:
1360:
1356:
1349:
1346:
1341:
1337:
1332:
1327:
1323:
1319:
1315:
1311:
1307:
1300:
1297:
1292:
1288:
1283:
1278:
1274:
1268:
1264:
1260:
1256:
1249:
1247:
1243:
1238:
1234:
1230:
1226:
1222:
1218:
1214:
1210:
1203:
1200:
1195:
1191:
1186:
1181:
1177:
1173:
1170:(9): 545–54.
1169:
1165:
1161:
1154:
1151:
1146:
1142:
1138:
1134:
1130:
1126:
1122:
1118:
1111:
1108:
1103:
1097:
1093:
1086:
1083:
1078:
1072:
1068:
1061:
1058:
1053:
1049:
1045:
1041:
1037:
1033:
1029:
1025:
1021:
1017:
1010:
1007:
1002:
998:
993:
988:
984:
980:
976:
969:
966:
961:
957:
953:
949:
945:
941:
937:
933:
926:
923:
918:
914:
910:
906:
902:
898:
895:(6): 337–44.
894:
890:
883:
880:
875:
871:
867:
863:
855:
852:
847:
843:
839:
835:
828:
825:
819:
815:
812:
811:
807:
805:
803:
799:
795:
791:
786:
784:
780:
776:
772:
768:
760:
754:
750:
747:
743:
736:
734:
732:
727:
723:
719:
715:
711:
707:
703:
699:
695:
691:
687:
683:
679:
675:
667:
662:
659:
656:
653:
650:
647:
644:
641:
640:
639:
633:
631:
624:
622:
620:
616:
612:
608:
604:
600:
596:
584:
581:
577:
574:
571:
567:
562:
558:
555:
552:
550:
546:
543:
540:
538:
534:
531:
528:
526:
522:
519:
516:
514:
510:
507:
504:
500:
495:
488:
483:
478:
467:
464:
460:
457:
454:
450:
445:
441:
438:
437:
433:
430:
428:
424:
419:
416:
413:
411:
407:
404:
401:
399:
395:
392:
389:
387:
383:
380:
377:
375:
371:
368:
365:
363:
359:
356:
353:
349:
344:
340:
336:
325:
322:
318:
315:
312:
308:
303:
299:
296:
295:
291:
288:
286:
282:
277:
274:
271:
269:
265:
262:
259:
257:
253:
250:
247:
245:
241:
238:
235:
233:
229:
226:
223:
221:
217:
214:
211:
207:
202:
197:
194:
193:
186:
181:
178:
174:
163:
160:
156:
153:
150:
146:
141:
137:
134:
133:
129:
126:
124:
120:
117:
114:
112:
108:
103:
100:
97:
95:
91:
88:
85:
83:
79:
76:
73:
71:
67:
64:
61:
59:
55:
52:
49:
47:
43:
40:
37:
33:
28:
24:
20:
3941:Translocases
3938:
3925:
3912:
3899:
3886:
3876:Transferases
3873:
3860:
3717:Binding site
3148:P70S6 kinase
2828:
2603:
1798:
1797:
1728:
1722:
1683:
1677:
1637:
1631:
1599:
1595:
1560:
1554:
1515:
1511:
1472:
1466:
1425:
1419:
1365:(1): 34–42.
1362:
1358:
1348:
1313:
1309:
1299:
1254:
1212:
1208:
1202:
1167:
1164:Cytoskeleton
1163:
1153:
1120:
1116:
1110:
1091:
1085:
1066:
1060:
1019:
1015:
1009:
982:
978:
968:
935:
931:
925:
892:
888:
882:
865:
854:
837:
827:
794:hypertension
787:
764:
740:
724:complex, as
688:or from the
671:
637:
628:
602:
598:
594:
593:
542:NM_001012418
434:
292:
190:
130:
3712:Active site
3599:(EC 2.7.12)
2986:Polo kinase
2926:Polo kinase
767:endothelial
710:crossbridge
613:a specific
573:Swiss-model
497:Identifiers
456:Swiss-model
346:Identifiers
314:Swiss-model
204:Identifiers
152:Swiss-model
30:Identifiers
3984:Categories
3915:Isomerases
3889:Hydrolases
3756:Regulation
2277:IÎşB kinase
1852:2.7.11-12)
889:IUBMB Life
820:References
746:ROC Kinase
694:calmodulin
651:– skeletal
569:Structures
564:Search for
452:Structures
447:Search for
421:Other data
310:Structures
305:Search for
279:Other data
148:Structures
143:Search for
105:Other data
4005:EC 2.7.11
3794:EC number
2403:PKC alpha
1745:0003-9861
1316:: 12–21.
657:– cardiac
619:myosin II
513:NCBI gene
403:NM_182493
362:NCBI gene
341:, cardiac
261:NM_033118
220:NCBI gene
116:2.7.11.18
111:EC number
87:NM_053025
46:NCBI gene
3818:Kinetics
3742:Cofactor
3705:Activity
2759:KIAA0999
2654:MAPKAPK5
2649:MAPKAPK3
2644:MAPKAPK2
1763:21565153
1710:17885681
1664:19038438
1656:16723733
1616:16306123
1587:16284075
1542:15825080
1499:15681825
1454:15507455
1397:22731713
1340:27543902
1291:28212798
1229:11568129
1194:20803696
1145:20486807
1137:29306925
1052:26554314
1044:12471243
960:11424747
952:28260490
917:46180993
909:11758800
808:See also
783:cadherin
733:(MLCP).
722:troponin
698:pp60 SRC
668:Function
634:Isoforms
583:InterPro
466:InterPro
324:InterPro
192:S. dubia
162:InterPro
132:qcen-q21
3974:Biology
3928:Ligases
3698:Enzymes
3418:MAP3K14
3396:MAP3K11
3391:MAP3K10
3381:MAP3K13
3376:MAP3K12
3178:RPS6KC1
3173:RPS6KA1
3168:RPS6KA3
3163:RPS6KA2
3158:RPS6KB2
3143:RPS6KA4
3138:RPS6KA5
2789:Kalirin
2754:SNF1LK2
1993:EIF2AK4
1988:EIF2AK3
1842:Kinases
1754:3382066
1701:1978424
1578:1464317
1533:1237051
1490:1237049
1445:1237105
1388:3384706
1367:Bibcode
1331:5253100
1282:5319769
1237:7042112
1185:3038199
1024:Bibcode
1016:Science
1001:9887970
682:calcium
674:enzymes
663:– novel
579:Domains
549:UniProt
462:Domains
432:Chr. 16
410:UniProt
320:Domains
290:Chr. 20
268:UniProt
196:centrin
158:Domains
94:UniProt
3960:Portal
3902:Lyases
3648:MAP2K7
3643:MAP2K6
3638:MAP2K5
3633:MAP2K4
3628:MAP2K3
3623:MAP2K2
3618:MAP2K1
3569:ACVRL1
3564:ACVR2B
3559:ACVR2A
3554:ACVR1C
3549:ACVR1B
3532:BMPR1B
3527:BMPR1A
3401:MAP3K7
3386:MAP3K9
3337:MAP3K8
3332:MAP3K7
3327:MAP3K6
3322:MAP3K5
3317:MAP3K4
3312:MAP3K3
3307:MAP3K2
3302:MAP3K1
3276:MAPK14
3271:MAPK13
3266:MAPK11
3254:MAPK10
3232:MAPK15
3227:MAPK12
3119:CDC2L1
3094:CDC2L5
2769:SNF1LK
2594:CAMK2G
2589:CAMK2D
2584:CAMK2B
2579:CAMK2A
2569:CAMK1G
2564:CAMK1D
2559:CAMK1B
2554:CAMK1A
2408:PRKCB1
2345:PRKACA
2340:PRKACB
2335:PRKACG
2311:IKBKAP
2137:BCKDHB
2132:BCKDHA
2106:PRKAG3
2101:PRKAG2
2096:PRKAG1
2086:PRKAB2
2081:PRKAB1
2071:PRKAA2
2066:PRKAA1
1911:STK38L
1794:(MeSH)
1784:(MeSH)
1761:
1751:
1743:
1708:
1698:
1662:
1654:
1614:
1585:
1575:
1540:
1530:
1497:
1487:
1452:
1442:
1395:
1385:
1338:
1328:
1289:
1279:
1269:
1235:
1227:
1192:
1182:
1143:
1135:
1098:
1073:
1050:
1042:
999:
958:
950:
915:
907:
796:, and
706:serine
678:muscle
672:These
554:Q86YV6
537:RefSeq
518:340156
502:Symbol
415:Q32MK0
398:RefSeq
391:612147
351:Symbol
294:q13.31
273:Q9H1R3
256:RefSeq
249:606566
209:Symbol
128:Chr. 3
99:Q15746
82:RefSeq
75:600922
35:Symbol
3854:Types
3610:MAP2K
3544:ACVR1
3537:BMPR2
3522:BMPR1
3447:GSK-3
3288:MAP3K
3249:MAPK9
3244:MAPK8
3222:MAPK7
3217:MAPK6
3212:MAPK4
3207:MAPK3
3202:MAPK1
3114:PFTK1
3109:PCTK3
3104:PCTK2
3099:PCTK1
3089:CDK12
3084:CDK10
3059:CDKL5
3039:CDKL2
2916:STK19
2911:EEF2K
2892:PHKG2
2887:PHKG1
2877:PHKA2
2872:PHKA1
2853:MYLK4
2848:MYLK3
2843:MYLK2
2819:DCLK1
2814:Titin
2804:TRIB3
2799:TRIB2
2794:TRIB1
2784:TSSK2
2764:STK40
2749:PSKH1
2744:PRKD3
2739:PRKD2
2719:PHKG2
2714:PHKG1
2704:OBSCN
2699:NUAK2
2694:NUAK1
2689:MKNK2
2684:MKNK1
2674:MARK4
2669:MARK3
2664:MARK2
2659:MARK1
2639:STK11
2634:DAPK3
2629:DAPK2
2624:DAPK1
2619:CHEK2
2614:CHEK1
2599:CAMK4
2574:CAMK2
2549:CAMK1
2544:BRSK2
2438:PRKCQ
2433:PRKCI
2428:PRKCG
2423:PRKCH
2418:PRKCE
2413:PRKCD
2374:PRKG1
2306:IKBKG
2301:IKBKE
2250:STK10
2245:FASTK
2171:IDH3G
2166:IDH3B
2161:IDH3A
2127:BCKDK
1921:ROCK1
1906:STK38
1901:MAST2
1896:MAST1
1891:LATS2
1886:LATS1
1660:S2CID
1628:(PDF)
1233:S2CID
1141:S2CID
1048:S2CID
956:S2CID
913:S2CID
661:MYLK4
655:MYLK3
649:MYLK2
643:MYLK1
609:that
605:is a
530:27972
506:MYLK4
436:q11.2
427:Locus
379:29826
367:91807
355:MYLK3
285:Locus
237:16243
225:85366
213:MYLK2
123:Locus
3946:list
3939:EC7
3933:list
3926:EC6
3920:list
3913:EC5
3907:list
3900:EC4
3894:list
3887:EC3
3881:list
3874:EC2
3868:list
3861:EC1
3437:TPK1
3413:CDC7
3371:MLKs
3364:KSR2
3359:KSR1
3354:BRAF
3349:ARAF
3344:RAFs
3079:CDK9
3074:CDK8
3069:CDK7
3064:CDK6
3054:CDK5
3049:CDK4
3044:CDK3
3034:CDK2
3029:CDK1
3010:PLK4
3005:PLK3
3000:PLK2
2995:PLK1
2950:PLK4
2945:PLK3
2940:PLK2
2935:PLK1
2882:PHKB
2838:MYLK
2809:TRIO
2779:SPEG
2774:SNRK
2734:PKD1
2729:PIM2
2724:PIM1
2709:PASK
2679:MELK
2609:CASK
2604:MLCK
2525:GRK6
2520:GRK5
2515:GRK4
2453:PKN3
2448:PKN2
2350:PRKY
2296:TBK1
2291:IKK2
2286:CHUK
2190:STK4
2156:IDH2
2041:PDK4
2036:PDK3
2031:PDK2
2026:PDK1
2005:WEE1
2000:Wee1
1968:mTOR
1956:AKT3
1951:AKT2
1946:AKT1
1936:SGK3
1931:SGK2
1759:PMID
1741:ISSN
1706:PMID
1652:PMID
1612:PMID
1583:PMID
1538:PMID
1495:PMID
1450:PMID
1393:PMID
1363:1258
1336:PMID
1287:PMID
1267:ISBN
1225:PMID
1190:PMID
1133:PMID
1096:ISBN
1071:ISBN
1040:PMID
997:PMID
948:PMID
905:PMID
744:and
603:MLCK
599:MYLK
525:HGNC
386:OMIM
374:HGNC
244:OMIM
232:HGNC
70:OMIM
63:7590
58:HGNC
51:4638
39:MYLK
3442:TTK
3406:ZAK
1983:HRI
1978:PKR
1926:SGK
1916:CIT
1749:PMC
1733:doi
1729:510
1696:PMC
1688:doi
1684:117
1642:doi
1638:119
1604:doi
1600:290
1573:PMC
1565:doi
1561:570
1528:PMC
1520:doi
1516:128
1485:PMC
1477:doi
1473:166
1440:PMC
1430:doi
1426:279
1383:PMC
1375:doi
1326:PMC
1318:doi
1314:180
1277:PMC
1259:doi
1217:doi
1180:PMC
1172:doi
1125:doi
1032:doi
1020:298
987:doi
983:164
940:doi
897:doi
870:doi
842:doi
704:at
601:or
3986::
2092:Îł
2077:β
2062:α
1850:EC
1844::
1757:.
1747:.
1739:.
1727:.
1721:.
1704:.
1694:.
1682:.
1676:.
1658:.
1650:.
1636:.
1630:.
1610:.
1598:.
1581:.
1571:.
1559:.
1553:.
1536:.
1526:.
1514:.
1510:.
1493:.
1483:.
1471:.
1465:.
1448:.
1438:.
1424:.
1418:.
1391:.
1381:.
1373:.
1361:.
1357:.
1334:.
1324:.
1312:.
1308:.
1285:.
1275:.
1265:.
1245:^
1231:.
1223:.
1213:91
1211:.
1188:.
1178:.
1168:67
1166:.
1162:.
1139:.
1131:.
1121:29
1119:.
1046:.
1038:.
1030:.
1018:.
995:.
981:.
977:.
954:.
946:.
936:81
934:.
911:.
903:.
893:51
891:.
868:.
864:.
840:.
836:.
792:,
621:.
3962::
3948:)
3944:(
3935:)
3931:(
3922:)
3918:(
3909:)
3905:(
3896:)
3892:(
3883:)
3879:(
3870:)
3866:(
3690:e
3683:t
3676:v
3499:-
3482:-
3465:-
2268:-
1848:(
1834:e
1827:t
1820:v
1807:.
1765:.
1735::
1712:.
1690::
1666:.
1644::
1618:.
1606::
1589:.
1567::
1544:.
1522::
1501:.
1479::
1456:.
1432::
1399:.
1377::
1369::
1342:.
1320::
1293:.
1261::
1239:.
1219::
1196:.
1174::
1147:.
1127::
1104:.
1079:.
1054:.
1034::
1026::
1003:.
989::
962:.
942::
919:.
899::
876:.
872::
848:.
844::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
