33:
315:
60:
819:
805:
454:
that would introduce genetic code into rabbit sperm and egg proteins. This mutation would induce an autoimmune response and inhibit fertility. This immunocontraceptive vaccine is still being tested for wild release.
559:"Virulence and pathogenesis of the MSW and MSD strains of Californian myxoma virus in European rabbits with genetic resistance to myxomatosis compared to rabbits with no genetic resistance"
439:
is very species-specific; it is able to circumvent a certain species of rabbit's immune response, but is unable to do so for any other species. The virus is able to get into the
910:
936:
311:
in diameter, 300 nm in length, and 200 nm in height. The middle contains a biconcave core that appears to be characteristic to many poxviruses.
503:
Fenner, Frank (1952). "The mechanism of the transmission of myxomatosis in the
European rabbit (Oryctolagus cuniculus) by the mosquito Aedes aegypti".
427:
hosts are susceptible to the virus, which means the virus can effectively evade the host immunity, but susceptibility is not the primary indicator for
416:
receptor mimics to reduce the host's natural response to TNF. The M-T2 protein is a soluble receptor that mimics the TNF receptors within rabbits.
203:
is found on the West Coast of the United States, the Baja
Peninsula of Mexico, and the southwest coast of Canada. South American or Brazilian
734:
435:, in which only the latter must be true before the virus is able to replicate in the cell and cause pathologies. This is the reason
447:, though, including human, mouse, and monkey, which is generally useless if it is unable to replicate and avoid the immune system.
969:
601:
Kerr, Peter; Ghedin, Elodie; et al. (2012), "Evolutionary
History and Attenuation of Myxoma Virus on Two Continents",
59:
32:
923:
941:
974:
964:
538:
Lockley, R.M. (1954). "The
European rabbit flea, Spilopsyllus cuniculi, as a vector of myxomatosis in Britain".
809:
378:
has multiple methods that it uses to evade the immune system. One route of protection involves blocking the
386:
protein, which is part of the caspase-1-activating inflammasome complex. By binding, it is able to inhibit
837:
413:
382:
activity within the host cells. The E13L viral protein is able to inhibit the caspases by binding to the
750:
Spiesschaert, Bart; McFadden, Grant; Hermans, Katleen; Nauwynck, Hans; Van de Walle, Gerlinde R (2011).
256:, and presumably other biting arthropods. It can also be spread through direct contact and contaminated
475:
are being developed to treat systemic inflammatory syndromes in people such as cardiovascular disease.
897:
480:
54:
248:
40:
364:
proteins. The extracellular proteins are used primarily for suppressing or circumventing the host
345:
108:
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283:; both the South and North American types are capable of causing this disease. Californian
272:
120:
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also can infect many types of human cancer cells, which is being used to develop it as a
778:
751:
625:
440:
296:
191:
156:
752:"The current status and future directions of myxoma virus, a master in immune evasion"
299:, and have a surface membrane with lateral bodies. The envelope contains host-derived
958:
365:
361:
357:
889:
224:
96:
84:
467:
has become of interest in human medicine because some of its proteins have strong
341:
around 40%, with terminally redundant sequences, which are repeated at both ends.
615:
869:
575:
558:
484:
428:
383:
368:, hence are nonessential. Infection is also initiated by extracellular virions.
304:
268:
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432:
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infection or pathology. A distinction must be made between susceptibility and
403:
338:
334:
308:
231:). In their native hosts, the viruses cause the formation of benign cutaneous
144:
132:
768:
387:
372:
matures naturally by budding through the surface membrane of the host cell.
928:
787:
725:(Second ed.). Burlington, MA: Jones & Bartlett Learning. pp.
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is nonsegmented and contains a single molecule of linear, double-stranded
854:
186:
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379:
232:
420:
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is passively transmitted on the mouth parts of mosquitoes, (such as
348:, 12 of which are duplicated in the terminal inverted repetitions.
313:
71:
424:
271:
is the name of the lethal disseminated disease that occurs when
253:
902:
835:
505:
Australian
Journal of Experimental Biology and Medical Science
450:
In 1993, the
Australian government approved a modification of
390:, which is normally induced by the CARD protein. In addition,
330:
691:. Büchen-Osmond, C. (Ed), Columbia University, New York, USA.
687:
ICTVdB Management (2006). 00.058.1.05.001. Myxoma virus. In:
708:, vol. I (3rd ed.), San Diego, CA: Academic Press
398:
viral gene to inhibit a variety of other caspases. The
207:
is found in South and
Central America. South American
844:
287:is particularly virulent, causing 100% mortality.
704:Mahy, Brian W J; Van Regenmortel, Marc H (2008),
647:Cheryl Cameron; et al. (25 November 1999).
356:During their normal lifecycles, virions produce
199:are Californian and South American. Californian
699:
697:
689:ICTVdB—The Universal Virus Database, version 4
8:
649:"The Complete DNA Sequence of Myxoma Virus"
596:
594:
832:
471:effects, and several of its virus-encoded
31:
20:
777:
767:
664:
624:
614:
574:
495:
307:. They are brick-shaped and about 250
7:
195:. The two broad geographic types of
402:gene is also capable of inhibiting
211:circulates in the jungle rabbit or
14:
817:
803:
58:
235:rather than systemic disease.
1:
412:is also capable of producing
706:The Encyclopedia of Virology
616:10.1371/journal.ppat.1002950
337:in length. The genome has a
576:10.1016/j.virol.2005.12.007
991:
53:
39:
30:
23:
769:10.1186/1297-9716-42-76
406:, a cysteine protease.
352:Infection and pathology
344:The genome encodes 170
219:), whereas Californian
217:Sylvilagus brasiliensis
666:10.1006/viro.1999.0001
322:
970:Animal viral diseases
722:Understanding Viruses
414:tumor necrosis factor
318:Evolution history of
317:
303:and self-synthesized
277:Oryctolagus cuniculus
814:at Wikimedia Commons
719:Shors, Teri (2013).
557:Silvers, L. (2006).
291:Structure and genome
279:) are infected with
55:Virus classification
756:Veterinary Research
517:10.1038/icb.1952.13
346:open reading frames
229:Sylvilagus bachmani
41:Electron micrograph
443:of many different
323:
223:circulates in the
110:Nucleocytoviricota
952:
951:
838:Taxon identifiers
808:Media related to
736:978-1-4496-4892-3
540:Veterinary Record
469:immunosuppressive
178:
177:
982:
975:Leporid diseases
965:Chordopoxvirinae
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919:
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906:
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822:Data related to
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609:(10): e1002950,
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473:immunomodulators
366:immune responses
273:European rabbits
63:
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35:
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16:Species of virus
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122:Pokkesviricetes
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828:at Wikispecies
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798:External links
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659:(2): 298–318.
639:
603:PLOS Pathogens
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549:
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511:(2): 139–152.
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433:permissibility
353:
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292:
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265:
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249:Aedes aegyptii
240:
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192:Leporipoxvirus
176:
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158:Leporipoxvirus
154:
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876:Myxoma virus
846:Myxoma virus
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811:Myxoma virus
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602:
569:(1): 72–83.
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498:
477:Myxoma virus
476:
465:myxoma virus
464:
462:
452:myxoma virus
451:
449:
437:myxoma virus
436:
418:
410:Myxoma virus
409:
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395:
392:myxoma virus
391:
376:Myxoma virus
375:
374:
370:Myxoma virus
369:
355:
343:
324:
320:myxoma virus
319:
295:Virions are
294:
285:myxoma virus
284:
281:myxoma virus
280:
276:
267:
247:
244:Myxoma virus
243:
242:
239:Transmission
228:
225:brush rabbit
221:myxoma virus
220:
216:
208:
205:myxoma virus
204:
201:myxoma virus
200:
197:myxoma virus
196:
190:
182:Myxoma virus
181:
180:
179:
171:Myxoma virus
170:
169:
157:
145:
134:Chitovirales
133:
121:
109:
98:Bamfordvirae
97:
86:Varidnaviria
85:
78:
68:(unranked):
45:Myxoma virus
44:
25:Myxoma virus
24:
18:
870:Wikispecies
485:virotherapy
429:symptomatic
339:G–C content
335:nucleotides
305:glycolipids
269:Myxomatosis
264:Myxomatosis
959:Categories
491:References
483:agent for
404:granzyme B
333:, 160,000
309:nanometers
146:Poxviridae
762:(1): 76.
394:uses the
388:apoptosis
297:enveloped
165:Species:
93:Kingdom:
916:11460328
861:Q6949366
855:Wikidata
788:21658227
675:10562494
653:Virology
635:23055928
585:16442580
563:Virology
525:14934625
459:Research
233:fibromas
187:poxvirus
141:Family:
105:Phylum:
779:3131250
626:3464225
445:species
380:caspase
258:fomites
153:Genus:
129:Order:
117:Class:
903:540229
786:
776:
733:
673:
633:
623:
583:
546:: 434.
523:
421:rabbit
400:Serp-2
396:Serp-2
327:genome
301:lipids
213:tapeti
48:virion
942:10273
929:96316
911:IRMNG
890:744V5
441:cells
419:Most
254:fleas
252:) or
185:is a
79:Realm
72:Virus
937:NCBI
784:PMID
731:ISBN
671:PMID
631:PMID
581:PMID
521:PMID
463:The
425:hare
423:and
384:CARD
360:and
325:The
924:ISC
898:EoL
885:CoL
774:PMC
764:doi
727:438
661:doi
657:264
621:PMC
611:doi
571:doi
567:348
513:doi
331:DNA
43:of
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782:.
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760:42
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
