242:
875:, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed.
219:
116:
141:
248:
147:
1891:
970:
Ishibashi K, Suzuki M, Sasaki S, Imai M (Mar 2001). "Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor".
1377:
1138:"Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver"
1005:
Liang Y, Tedder TF (Jun 2001). "Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse".
255:
154:
1811:
1871:
1322:"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries"
1370:
567:
548:
77:
1607:
1602:
1960:
1355:
1936:
952:
1955:
1363:
934:
241:
1574:
795:
802:
218:
1043:
921:
900:
1579:
1062:
Liang Y, Buckley TR, Tu L, et al. (2001). "Structural organization of the human MS4A gene cluster on
Chromosome 11q12".
140:
115:
917:
896:
57:
254:
153:
1929:
1562:
247:
146:
612:
65:
1279:"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"
1843:
593:
1922:
1567:
1394:
1099:
Gingras MC, Lapillonne H, Margolin JF (2001). "CFFM4: a new member of the CD20/FcepsilonRIbeta family".
129:
1594:
1550:
1444:
1202:
1149:
872:
44:
1584:
717:
713:
1124:
1087:
89:
1191:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
759:
755:
751:
747:
721:
692:
688:
684:
680:
1343:
1308:
1265:
1230:
1177:
1116:
1079:
1022:
987:
37:
1906:
1790:
1785:
1730:
1720:
1715:
1705:
1700:
1695:
1675:
1816:
1645:
1625:
1532:
1527:
1522:
1517:
1512:
1507:
1497:
1487:
1482:
1472:
1467:
1390:
1333:
1298:
1290:
1255:
1220:
1210:
1167:
1157:
1108:
1071:
1014:
979:
334:
265:
209:
164:
1502:
1477:
85:
1429:
1424:
309:
1206:
1153:
1303:
1278:
1225:
1190:
983:
1949:
1902:
1172:
1137:
1128:
1091:
69:
1402:
327:
106:
93:
1755:
1617:
957:
National Center for
Biotechnology Information, U.S. National Library of Medicine
939:
National Center for
Biotechnology Information, U.S. National Library of Medicine
410:
1838:
1821:
1419:
1338:
1321:
226:
123:
73:
1848:
1244:"Complete sequencing and characterization of 21,243 full-length human cDNAs"
512:
470:
348:
293:
280:
192:
179:
81:
1347:
1312:
1269:
1234:
1215:
1181:
1162:
1120:
1083:
1026:
1018:
991:
1112:
1075:
842:
837:
1806:
1411:
826:
638:
1780:
1775:
1735:
1725:
1710:
1690:
1685:
1680:
1670:
1386:
1294:
1044:"Entrez Gene: MS4A7 membrane-spanning 4-domains, subfamily A, member 7"
858:
624:
579:
1665:
1660:
1655:
1650:
1640:
1635:
1630:
1542:
1398:
810:
534:
1890:
1260:
1243:
1831:
1826:
1740:
1462:
1457:
1898:
1858:
1853:
1770:
1760:
1750:
1745:
1555:
1452:
1434:
865:
61:
1359:
1765:
48:, 4SPAN2, CD20L4, CFFM4, MS4A8, membrane spanning 4-domains A7
1189:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
317:
1910:
1277:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
482:
1799:
1616:
1593:
1541:
1443:
1410:
773:
740:
706:
673:
1320:Otsuki T, Ota T, Nishikawa T, et al. (2007).
1242:Ota T, Suzuki Y, Nishikawa T, et al. (2004).
913:
911:
909:
892:
890:
888:
264:
163:
855:Membrane-spanning 4-domains subfamily A member 7
1812:LDL-receptor-related protein-associated protein
16:Protein-coding gene in the species Homo sapiens
918:GRCm38: Ensembl release 89: ENSMUSG00000024672
1930:
1371:
8:
1136:Xu XR, Huang J, Xu ZG, et al. (2002).
897:GRCh38: Ensembl release 89: ENSG00000166927
1937:
1923:
1378:
1364:
1356:
508:
305:
204:
101:
1608:Pulmonary surfactant-associated protein C
1603:Pulmonary surfactant-associated protein B
1337:
1302:
1259:
1224:
1214:
1171:
1161:
1038:
1036:
884:
18:
1872:other cell membrane protein disorders
269:
230:
225:
168:
127:
122:
7:
1887:
1885:
1575:Myelin oligodendrocyte glycoprotein
1909:. You can help Knowledge (XXG) by
871:This gene encodes a member of the
770:
737:
703:
670:
648:
629:
603:
584:
558:
539:
487:
405:
343:
322:
14:
861:that in humans is encoded by the
1889:
873:membrane-spanning 4A gene family
253:
246:
240:
217:
152:
145:
139:
114:
1961:Human chromosome 11 gene stubs
1844:Phospholipid transfer proteins
1580:Myelin-associated glycoprotein
471:More reference expression data
1:
984:10.1016/S0378-1119(00)00598-9
449:vestibular sensory epithelium
238:
137:
1956:Genes on human chromosome 11
1195:Proc. Natl. Acad. Sci. U.S.A
1142:Proc. Natl. Acad. Sci. U.S.A
1977:
1884:
1563:Myelin proteolipid protein
1867:
953:"Mouse PubMed Reference:"
935:"Human PubMed Reference:"
841:
836:
832:
825:
809:
790:
777:
744:
733:
710:
677:
666:
655:
651:
636:
632:
623:
610:
606:
591:
587:
578:
565:
561:
546:
542:
533:
518:
511:
507:
495:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
1339:10.1093/dnares/12.2.117
803:Chr 19: 11.3 – 11.31 Mb
796:Chr 11: 60.38 – 60.4 Mb
441:external carotid artery
433:internal carotid artery
425:interventricular septum
375:upper lobe of left lung
1216:10.1073/pnas.242603899
1163:10.1073/pnas.241522398
1019:10.1006/geno.2000.6472
445:mesenteric lymph nodes
1395:Cell surface receptor
1113:10.1007/s002510100345
1076:10.1007/s002510100339
421:stroma of bone marrow
232:Chromosome 19 (mouse)
130:Chromosome 11 (human)
1595:Pulmonary surfactant
1551:Myelin basic protein
1445:Membrane-spanning 4A
1585:Myelin protein zero
1207:2002PNAS...9916899M
1154:2001PNAS...9815089X
1897:This article on a
1295:10.1101/gr.2596504
613:ENSMUSG00000024672
395:lower lobe of lung
1918:
1917:
1879:
1878:
1391:membrane proteins
1201:(26): 16899–903.
852:
851:
848:
847:
821:
820:
786:
785:
767:
766:
729:
728:
700:
699:
662:
661:
645:
644:
619:
618:
600:
599:
574:
573:
555:
554:
503:
502:
499:
498:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
94:MS4A7 - orthologs
1968:
1939:
1932:
1925:
1893:
1886:
1380:
1373:
1366:
1357:
1351:
1341:
1316:
1306:
1273:
1263:
1238:
1228:
1218:
1185:
1175:
1165:
1148:(26): 15089–94.
1132:
1095:
1048:
1047:
1040:
1031:
1030:
1002:
996:
995:
967:
961:
960:
949:
943:
942:
931:
925:
915:
904:
894:
834:
833:
805:
798:
781:
771:
762:
738:
734:RefSeq (protein)
724:
704:
695:
671:
649:
630:
604:
585:
559:
540:
509:
488:
473:
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
1976:
1975:
1971:
1970:
1969:
1967:
1966:
1965:
1946:
1945:
1944:
1943:
1882:
1880:
1875:
1863:
1817:Neurofibromin 2
1800:Other/ungrouped
1795:
1612:
1589:
1537:
1439:
1406:
1384:
1354:
1319:
1289:(10B): 2121–7.
1276:
1241:
1188:
1135:
1098:
1061:
1057:
1055:Further reading
1052:
1051:
1042:
1041:
1034:
1004:
1003:
999:
969:
968:
964:
951:
950:
946:
933:
932:
928:
916:
907:
895:
886:
881:
843:View/Edit Mouse
838:View/Edit Human
801:
794:
791:Location (UCSC)
779:
758:
754:
750:
746:
720:
716:
712:
691:
687:
683:
679:
594:ENSG00000166927
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
391:trabecular bone
389:
385:
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1974:
1972:
1964:
1963:
1958:
1948:
1947:
1942:
1941:
1934:
1927:
1919:
1916:
1915:
1894:
1877:
1876:
1868:
1865:
1864:
1862:
1861:
1856:
1851:
1846:
1841:
1836:
1835:
1834:
1829:
1819:
1814:
1809:
1803:
1801:
1797:
1796:
1794:
1793:
1788:
1783:
1778:
1773:
1768:
1763:
1758:
1753:
1748:
1743:
1738:
1733:
1728:
1723:
1718:
1713:
1708:
1703:
1698:
1693:
1688:
1683:
1678:
1673:
1668:
1663:
1658:
1653:
1648:
1643:
1638:
1633:
1628:
1622:
1620:
1614:
1613:
1611:
1610:
1605:
1599:
1597:
1591:
1590:
1588:
1587:
1582:
1577:
1572:
1571:
1570:
1560:
1559:
1558:
1547:
1545:
1539:
1538:
1536:
1535:
1530:
1525:
1520:
1515:
1510:
1505:
1500:
1495:
1490:
1485:
1480:
1475:
1470:
1465:
1460:
1455:
1449:
1447:
1441:
1440:
1438:
1437:
1432:
1427:
1422:
1416:
1414:
1408:
1407:
1385:
1383:
1382:
1375:
1368:
1360:
1353:
1352:
1317:
1274:
1261:10.1038/ng1285
1239:
1186:
1133:
1101:Immunogenetics
1096:
1064:Immunogenetics
1058:
1056:
1053:
1050:
1049:
1032:
997:
962:
944:
926:
905:
883:
882:
880:
877:
850:
849:
846:
845:
840:
830:
829:
823:
822:
819:
818:
816:
814:
807:
806:
799:
792:
788:
787:
784:
783:
775:
774:
768:
765:
764:
742:
741:
735:
731:
730:
727:
726:
708:
707:
701:
698:
697:
675:
674:
668:
664:
663:
660:
659:
653:
652:
646:
643:
642:
634:
633:
627:
621:
620:
617:
616:
608:
607:
601:
598:
597:
589:
588:
582:
576:
575:
572:
571:
563:
562:
556:
553:
552:
544:
543:
537:
531:
530:
525:
520:
516:
515:
505:
504:
501:
500:
497:
496:
493:
492:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1973:
1962:
1959:
1957:
1954:
1953:
1951:
1940:
1935:
1933:
1928:
1926:
1921:
1920:
1914:
1912:
1908:
1904:
1903:chromosome 11
1900:
1895:
1892:
1888:
1883:
1874:
1873:
1866:
1860:
1857:
1855:
1852:
1850:
1847:
1845:
1842:
1840:
1837:
1833:
1830:
1828:
1825:
1824:
1823:
1820:
1818:
1815:
1813:
1810:
1808:
1805:
1804:
1802:
1798:
1792:
1789:
1787:
1784:
1782:
1779:
1777:
1774:
1772:
1769:
1767:
1764:
1762:
1759:
1757:
1754:
1752:
1749:
1747:
1744:
1742:
1739:
1737:
1734:
1732:
1729:
1727:
1724:
1722:
1719:
1717:
1714:
1712:
1709:
1707:
1704:
1702:
1699:
1697:
1694:
1692:
1689:
1687:
1684:
1682:
1679:
1677:
1674:
1672:
1669:
1667:
1664:
1662:
1659:
1657:
1654:
1652:
1649:
1647:
1644:
1642:
1639:
1637:
1634:
1632:
1629:
1627:
1624:
1623:
1621:
1619:
1615:
1609:
1606:
1604:
1601:
1600:
1598:
1596:
1592:
1586:
1583:
1581:
1578:
1576:
1573:
1569:
1566:
1565:
1564:
1561:
1557:
1554:
1553:
1552:
1549:
1548:
1546:
1544:
1540:
1534:
1531:
1529:
1526:
1524:
1521:
1519:
1516:
1514:
1511:
1509:
1506:
1504:
1501:
1499:
1496:
1494:
1491:
1489:
1486:
1484:
1481:
1479:
1476:
1474:
1471:
1469:
1466:
1464:
1461:
1459:
1456:
1454:
1451:
1450:
1448:
1446:
1442:
1436:
1433:
1431:
1428:
1426:
1423:
1421:
1418:
1417:
1415:
1413:
1409:
1404:
1400:
1396:
1392:
1388:
1381:
1376:
1374:
1369:
1367:
1362:
1361:
1358:
1349:
1345:
1340:
1335:
1332:(2): 117–26.
1331:
1327:
1323:
1318:
1314:
1310:
1305:
1300:
1296:
1292:
1288:
1284:
1280:
1275:
1271:
1267:
1262:
1257:
1253:
1249:
1245:
1240:
1236:
1232:
1227:
1222:
1217:
1212:
1208:
1204:
1200:
1196:
1192:
1187:
1183:
1179:
1174:
1169:
1164:
1159:
1155:
1151:
1147:
1143:
1139:
1134:
1130:
1126:
1122:
1118:
1114:
1110:
1107:(6): 468–76.
1106:
1102:
1097:
1093:
1089:
1085:
1081:
1077:
1073:
1070:(5): 357–68.
1069:
1065:
1060:
1059:
1054:
1045:
1039:
1037:
1033:
1028:
1024:
1020:
1016:
1013:(2): 119–27.
1012:
1008:
1001:
998:
993:
989:
985:
981:
977:
973:
966:
963:
958:
954:
948:
945:
940:
936:
930:
927:
923:
919:
914:
912:
910:
906:
902:
898:
893:
891:
889:
885:
878:
876:
874:
869:
867:
864:
860:
856:
844:
839:
835:
831:
828:
824:
817:
815:
812:
808:
804:
800:
797:
793:
789:
782:
776:
772:
769:
763:
761:
757:
753:
749:
743:
739:
736:
732:
725:
723:
719:
715:
709:
705:
702:
696:
694:
690:
686:
682:
676:
672:
669:
667:RefSeq (mRNA)
665:
658:
654:
650:
647:
641:
640:
635:
631:
628:
626:
622:
615:
614:
609:
605:
602:
596:
595:
590:
586:
583:
581:
577:
570:
569:
564:
560:
557:
551:
550:
545:
541:
538:
536:
532:
529:
526:
524:
521:
517:
514:
510:
506:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1911:expanding it
1896:
1881:
1869:
1492:
1403:cytoskeleton
1393:(other than
1329:
1325:
1286:
1282:
1251:
1247:
1198:
1194:
1145:
1141:
1104:
1100:
1067:
1063:
1010:
1006:
1000:
978:(1): 87–93.
975:
971:
965:
956:
947:
938:
929:
870:
862:
854:
853:
778:
745:
718:NM_001276398
714:NM_001025610
711:
678:
656:
637:
611:
592:
566:
547:
527:
522:
333:
326:
271:19|19 A
53:External IDs
1618:Tetraspanin
1254:(1): 40–5.
379:granulocyte
367:gallbladder
292:11,313,510
279:11,298,403
191:60,395,951
178:60,378,485
31:Identifiers
1950:Categories
1822:Presenilin
1283:Genome Res
1248:Nat. Genet
924:, May 2017
903:, May 2017
879:References
383:right lung
337:(ortholog)
74:HomoloGene
1901:on human
1870:see also
1849:Dysferlin
760:NP_996823
756:NP_996822
752:NP_996821
748:NP_067024
722:NM_027836
693:NM_206939
689:NM_206938
685:NM_021201
681:NM_206940
513:Orthologs
82:GeneCards
1807:Calnexin
1412:Arrestin
1348:16303743
1313:15489334
1270:14702039
1235:12477932
1182:11752456
1129:29981957
1121:11685457
1092:21846867
1084:11486273
1027:11401424
1007:Genomics
992:11245982
920:–
899:–
827:Wikidata
429:calvaria
371:appendix
359:monocyte
1791:TSPAN34
1786:TSPAN33
1781:TSPAN32
1776:TSPAN31
1771:TSPAN30
1766:TSPAN29
1761:TSPAN28
1756:TSPAN27
1751:TSPAN26
1746:TSPAN25
1741:TSPAN24
1736:TSPAN23
1731:TSPAN22
1726:TSPAN21
1721:TSPAN20
1716:TSPAN19
1711:TSPAN18
1706:TSPAN17
1701:TSPAN16
1696:TSPAN15
1691:TSPAN14
1686:TSPAN13
1681:TSPAN12
1676:TSPAN11
1671:TSPAN10
1399:enzymes
1389:: cell
1387:Protein
1326:DNA Res
1203:Bibcode
1150:Bibcode
922:Ensembl
901:Ensembl
859:protein
625:UniProt
580:Ensembl
519:Species
312:pattern
170:11q12.2
70:1918846
38:Aliases
1666:TSPAN9
1661:TSPAN8
1656:TSPAN7
1651:TSPAN6
1646:TSPAN5
1641:TSPAN4
1636:TSPAN3
1631:TSPAN2
1626:TSPAN1
1543:Myelin
1533:MS4A18
1528:MS4A15
1523:MS4A14
1518:MS4A13
1513:MS4A12
1508:MS4A10
1498:MS4A8B
1488:MS4A6E
1483:MS4A6A
1473:MS4A4E
1468:MS4A4A
1401:, and
1346:
1311:
1304:528928
1301:
1268:
1233:
1226:139241
1223:
1180:
1170:
1127:
1119:
1090:
1082:
1025:
990:
813:search
811:PubMed
639:Q9GZW8
568:109225
535:Entrez
483:BioGPS
457:spleen
453:thymus
437:cervix
387:rectum
363:spleen
62:606502
1905:is a
1832:PSEN2
1827:PSEN1
1503:MS4A9
1493:MS4A7
1478:MS4A5
1463:MS4A3
1458:MS4A2
1453:MS4A1
1430:ARRB2
1425:ARRB1
1173:64988
1125:S2CID
1088:S2CID
863:MS4A7
857:is a
549:58475
528:Mouse
523:Human
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
86:MS4A7
78:10922
45:MS4A7
22:MS4A7
1907:stub
1899:gene
1859:OTOF
1854:STRC
1568:PLP1
1556:PMP2
1435:ARR3
1344:PMID
1309:PMID
1266:PMID
1231:PMID
1178:PMID
1117:PMID
1080:PMID
1023:PMID
988:PMID
972:Gene
866:gene
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
1839:HFE
1420:SAG
1334:doi
1299:PMC
1291:doi
1256:doi
1221:PMC
1211:doi
1168:PMC
1158:doi
1109:doi
1072:doi
1015:doi
980:doi
976:264
780:n/a
657:n/a
491:n/a
288:End
187:End
90:OMA
66:MGI
1952::
1397:,
1342:.
1330:12
1328:.
1324:.
1307:.
1297:.
1287:14
1285:.
1281:.
1264:.
1252:36
1250:.
1246:.
1229:.
1219:.
1209:.
1199:99
1197:.
1193:.
1176:.
1166:.
1156:.
1146:98
1144:.
1140:.
1123:.
1115:.
1105:53
1103:.
1086:.
1078:.
1068:53
1066:.
1035:^
1021:.
1011:72
1009:.
986:.
974:.
955:.
937:.
908:^
887:^
868:.
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
1938:e
1931:t
1924:v
1913:.
1405:)
1379:e
1372:t
1365:v
1350:.
1336::
1315:.
1293::
1272:.
1258::
1237:.
1213::
1205::
1184:.
1160::
1152::
1131:.
1111::
1094:.
1074::
1046:.
1029:.
1017::
994:.
982::
959:.
941:.
212:)
109:)
92::
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