244:
221:
118:
143:
495:
250:
149:
2023:
Lai LP, Lin JL, Lin CS, Yeh HM, Tsay YG, Lee CF, Lee HH, Chang ZF, Hwang JJ, Su MJ, Tseng YZ, Huang SK (February 2004). "Functional genomic study on atrial fibrillation using cDNA microarray and two-dimensional protein electrophoresis techniques and identification of the myosin regulatory light chain
2067:
Chen MC, Chang JP, Chang TH, Hsu SD, Huang HD, Ho WC, Wang FS, Hsiao CC, Liu WH (May 2015). "Unraveling regulatory mechanisms of atrial remodeling of mitral regurgitation pigs by gene expression profiling analysis: role of type I angiotensin II receptor antagonist".
1623:
Ovchinnikov DA, Hidalgo A, Yang SK, Zhang X, Hudson J, Mazzone SB, Chen C, Cooper-White JJ, Wolvetang EJ (January 2015). "Isolation of contractile cardiomyocytes from human pluripotent stem-cell-derived cardiomyogenic cultures using a human NCX1-EGFP reporter".
2445:
Wankerl M, Böhm M, Morano I, Rüegg JC, Eichhorn M, Erdmann E (December 1990). "Calcium sensitivity and myosin light chain pattern of atrial and ventricular skinned cardiac fibers from patients with various kinds of cardiac disease".
1864:
Henkel RD, Kammerer CM, Escobedo LV, VandeBerg JL, Walsh RA (March 1993). "Correlated expression of atrial myosin heavy chain and regulatory light chain isoforms with pressure overload hypertrophy in the non-human primate".
2295:
Wakili R, Yeh YH, Yan Qi X, Greiser M, Chartier D, Nishida K, Maguy A, Villeneuve LR, Boknik P, Voigt N, Krysiak J, Kääb S, Ravens U, Linke WA, Stienen GJ, Shi Y, Tardif JC, Schotten U, Dobrev D, Nattel S (October 2010).
2579:
Ching YH, Ghosh TK, Cross SJ, Packham EA, Honeyman L, Loughna S, Robinson TE, Dearlove AM, Ribas G, Bonser AJ, Thomas NR, Scotter AJ, Caves LS, Tyrrell GP, Newbury-Ecob RA, Munnich A, Bonnet D, Brook JD (April 2005).
2533:
Ching YH, Ghosh TK, Cross SJ, Packham EA, Honeyman L, Loughna S, Robinson TE, Dearlove AM, Ribas G, Bonser AJ, Thomas NR, Scotter AJ, Caves LS, Tyrrell GP, Newbury-Ecob RA, Munnich A, Bonnet D, Brook JD (April 2005).
2347:
Kockskämper J, Khafaga M, Grimm M, Elgner A, Walther S, Kockskämper A, von
Lewinski D, Post H, Grossmann M, Dörge H, Gottlieb PA, Sachs F, Eschenhagen T, Schöndube FA, Pieske B (September 2008).
1780:
Doevendans PA, Bronsaer R, Lozano PR, Kubalak S, van Bilsen M (2000). "The murine atrial myosin light chain-2 gene: a member of an evolutionarily conserved family of contractile proteins".
257:
156:
1516:
2813:
678:
659:
79:
2156:"A novel, in-solution separation of endogenous cardiac sarcomeric proteins and identification of distinct charged variants of regulatory light chain"
1153:; and this change precedes any detectable pressure overloading of the heart, suggesting that this change is a very early functional adaptation to
2617:"Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium"
2256:"Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium"
1443:
1425:
3441:
5133:
5128:
243:
2806:
2483:"Transitions in human atrial and ventricular myosin light-chain isoenzymes in response to cardiac-pressure-overload-induced hypertrophy"
2349:"Angiotensin II and myosin light-chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium"
1757:
1740:
2223:
2206:
2721:
1669:
Hudson J, Titmarsh D, Hidalgo A, Wolvetang E, Cooper-White J (June 2012). "Primitive cardiac cells from human embryonic stem cells".
1097:
in the vertebrate heart. Functional insights into ALC-2 function have come from studies employing transgenesis. A study in which the
878:
220:
885:
2105:"Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivo"
1502:
1943:"Effects of total replacement of atrial myosin light chain-2 with the ventricular isoform in atrial myocytes of transgenic mice"
3960:
1412:
1391:
4229:
4072:
2799:
1408:
142:
117:
5108:
4662:
1524:
2398:"Expression profiling of cardiac genes in human hypertrophic cardiomyopathy: insight into the pathogenesis of phenotypes"
1387:
1902:"Cardiac myosin light chain-2: a novel essential component of thick-myofilament assembly and contractility of the heart"
59:
2298:"Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs"
1034:
chamber distinction, development and differentiation. ALC-2 shows a pattern distinct from atrial essential light chain
3369:
1357:
1283:
967:
2615:
Grimm M, Haas P, Willipinski-Stapelfeldt B, Zimmermann WH, Rau T, Pantel K, Weyand M, Eschenhagen T (January 2005).
2254:
Grimm M, Haas P, Willipinski-Stapelfeldt B, Zimmermann WH, Rau T, Pantel K, Weyand M, Eschenhagen T (January 2005).
256:
155:
4840:
2720:
Nishigaki R, Shinohara T, Toda T, Omori A, Ichinose S, Itoh M, Shirayoshi Y, Kurimasa A, Oshimura M (July 2002).
1271:
1241:
1189:
249:
148:
2297:
1825:"Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis"
1463:"Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis"
5073:
1741:"Myosin light chain 2a and 2v identifies the embryonic outflow tract myocardium in the developing rodent heart"
723:
67:
2758:"Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development"
2685:
Bird SD, Doevendans PA, van
Rooijen MA, Brutel de la Riviere A, Hassink RJ, Passier R, Mummery CL (May 2003).
2652:"Functional divergence of human cytoplasmic myosin II: kinetic characterization of the non-muscle IIA isoform"
1291:
975:
704:
1941:
Pawloski-Dahm CM, Song G, Kirkpatrick DL, Palermo J, Gulick J, Dorn GW, Robbins J, Walsh RA (April 1998).
1900:
Rottbauer W, Wessels G, Dahme T, Just S, Trano N, Hassel D, Burns CG, Katus HA, Fishman MC (August 2006).
1633:
1311:
1299:
1295:
971:
1984:"Expression of ventricular-type myosin light chain messenger RNA in spontaneously hypertensive rat atria"
3492:
2846:
2154:
Scruggs SB, Reisdorph R, Armstrong ML, Warren CM, Reisdorph N, Solaro RJ, Buttrick PM (September 2010).
1704:
Small EM, Krieg PA (January 2004). "Molecular regulation of cardiac chamber-specific gene expression".
3761:
2756:
Hailstones D, Barton P, Chan-Thomas P, Sasse S, Sutherland C, Hardeman E, Gunning P (November 1992).
1638:
1326:
1287:
1174:
131:
46:
1551:"Three-dimensional structure of myosin subfragment-1 from electron microscopy of sectioned crystals"
5068:
3701:
1303:
1245:
1217:
1158:
1154:
3521:
3151:
2236:
2049:
1805:
1165:
expression showed the greatest change, being upregulated 9.4-fold and 7.3-fold in left and right
1113:
91:
861:
840:
814:
793:
1137:
In disease models, ALC-2 expression in some instances can be downregulated and replaced by the
4919:
4622:
3283:
2779:
2744:
2708:
2673:
2638:
2603:
2557:
2512:
2463:
2427:
2378:
2329:
2277:
2228:
2187:
2136:
2085:
2041:
2005:
1964:
1923:
1882:
1846:
1797:
1762:
1721:
1686:
1651:
1580:
1484:
1330:
1201:
1128:
1055:
999:
39:
4642:
1599:"Protein sequence alignment for human cardiac atrial and ventricular regulatory light chains"
4867:
4574:
4559:
4554:
4549:
4544:
4534:
4455:
4164:
4144:
4114:
4109:
3991:
3346:
3341:
2769:
2736:
2698:
2663:
2628:
2593:
2547:
2502:
2494:
2455:
2417:
2409:
2368:
2360:
2319:
2309:
2267:
2218:
2177:
2167:
2126:
2116:
2077:
2033:
1995:
1954:
1913:
1874:
1836:
1789:
1752:
1713:
1678:
1643:
1570:
1562:
1474:
336:
267:
211:
166:
4784:
4779:
4774:
4769:
4524:
4514:
4504:
4499:
4470:
4174:
4169:
3216:
3104:
3094:
3069:
3049:
2953:
2933:
2722:"An extra human chromosome 21 reduces mlc-2a expression in chimeric mice and Down syndrome"
5009:
3623:
3473:
3356:
3176:
1267:
1259:
1229:
1213:
1205:
1059:
494:
311:
87:
4972:
4835:
3532:
3363:
2872:
2507:
2482:
2422:
2397:
2373:
2348:
2182:
2155:
2131:
2104:
1918:
1901:
1575:
1550:
1315:
1307:
1263:
1249:
1225:
1170:
1166:
1150:
1131:
1124:
1121:
1106:
1102:
1083:
1071:
1047:
1039:
1031:
959:
956:
2774:
2757:
2740:
2703:
2686:
2413:
1841:
1824:
1479:
1462:
593:
577:
572:
567:
562:
546:
541:
536:
5122:
5036:
5031:
3996:
3866:
3815:
3765:
3705:
3627:
3595:
3536:
3322:
2841:
2459:
2037:
1252:
1233:
1221:
1117:
1094:
963:
523:
2633:
2616:
2272:
2255:
2240:
2053:
1809:
1598:
1204:
isoform that is shown to be deamidated (thus producing a negative charge similar to
4880:
3935:
3690:
3234:
2826:
1142:
990:
has a molecular weight of 19.4 kDa and is composed of 175 amino acids. ALC-2 is an
329:
108:
71:
4852:
4830:
95:
5026:
4977:
4847:
4737:
4067:
3511:
3466:
3385:
3307:
2855:
1448:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1430:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2791:
2081:
1739:
Franco D, Markman MM, Wagenaar GT, Ya J, Lamers WH, Moorman AF (January 1999).
1286:
shown an increased expression of ALC-2 in whole heart tissue. In patients with
1212:-14 of human ALC-2 is also phosphorylated remains to be determined. Endogenous
962:
in healthy individuals, where it functions to modulate cardiac development and
412:
5078:
4997:
4987:
4875:
3986:
3965:
3731:
3668:
3663:
3658:
3638:
3613:
3601:
3587:
3582:
3577:
3572:
3567:
3562:
3557:
3552:
3547:
3409:
3291:
3280:
3266:
2882:
2314:
1959:
1942:
1717:
1337:
1333:
1237:
1197:
1181:
1019:
1007:
228:
125:
75:
2000:
1983:
4907:
4902:
4897:
4857:
4695:
4690:
4685:
4043:
4023:
3678:
3673:
3653:
3648:
3643:
3633:
3542:
3446:
3380:
2172:
2121:
2103:
Ding P, Huang J, Battiprolu PK, Hill JA, Kamm KE, Stull JT (December 2010).
1090:
623:
472:
350:
295:
282:
194:
181:
83:
2748:
2712:
2677:
2668:
2651:
2642:
2607:
2561:
2431:
2382:
2333:
2281:
2191:
2140:
2089:
2045:
1927:
1878:
1801:
1758:
10.1002/(sici)1097-0185(19990101)254:1<135::aid-ar17>3.3.co;2-j
1725:
1690:
1655:
2783:
2516:
2467:
2232:
2224:
10.1002/(sici)1097-4644(19971101)67:2<241::aid-jcb9>3.0.co;2-x
2009:
1968:
1886:
1850:
1766:
1682:
1647:
1584:
1566:
1488:
925:
920:
5021:
4982:
4914:
4887:
4754:
4742:
4617:
4612:
4053:
4048:
3970:
3404:
3399:
3261:
2364:
1109:
909:
768:
749:
1823:
Kubalak SW, Miller-Hance WC, O'Brien TX, Dyson E, Chien KR (June 1994).
1461:
Kubalak SW, Miller-Hance WC, O'Brien TX, Dyson E, Chien KR (June 1994).
5048:
5002:
4892:
4822:
4791:
4721:
4716:
4680:
4675:
4670:
4637:
4607:
4602:
4597:
4592:
4277:
4209:
4204:
4199:
4194:
4189:
4081:
4018:
3506:
3451:
3392:
3375:
3336:
2822:
1319:
991:
987:
945:
735:
690:
2498:
2324:
1793:
4967:
4949:
4944:
4939:
4934:
4924:
4759:
4652:
4647:
4632:
4627:
4539:
4485:
4450:
4425:
4420:
4415:
4410:
4400:
4395:
4385:
4370:
4365:
4247:
4242:
4237:
4149:
4139:
4119:
4104:
4099:
4094:
4089:
3955:
3726:
3721:
3478:
3144:
3139:
3129:
2907:
1256:
1209:
1193:
1185:
1078:. Expression of ALC-2 has been shown to correlate with expression of
1075:
1063:
1043:
1015:
1011:
893:
645:
1982:
Kumar C, Saidapet C, Delaney P, Mendola C, Siddiqui MA (June 1988).
2598:
2581:
2552:
2535:
2207:"In vitro motility assay of atrial and ventricular myosin from pig"
4992:
4764:
4747:
4584:
4579:
4569:
4564:
4529:
4519:
4509:
4494:
4475:
4465:
4460:
4445:
4440:
4435:
4430:
4405:
4390:
4380:
4375:
4360:
4355:
4335:
4330:
4325:
4320:
4315:
4310:
4305:
4300:
4295:
4290:
4285:
4257:
4252:
4219:
4214:
4184:
4179:
4159:
4154:
4134:
4124:
4039:
3917:
3912:
3907:
3902:
3897:
3892:
3887:
3882:
3877:
3872:
3856:
3851:
3846:
3841:
3836:
3831:
3826:
3821:
3796:
3791:
3786:
3781:
3776:
3771:
3751:
3746:
3741:
3736:
3716:
3711:
3421:
3351:
3300:
3297:
3294:
3286:
3275:
3272:
3269:
3254:
3249:
3244:
3239:
3211:
3201:
3186:
3119:
3109:
3089:
3064:
3059:
3044:
3034:
3029:
3024:
3019:
3014:
3009:
2994:
2948:
2943:
2938:
2928:
2923:
2918:
2897:
2892:
2887:
2877:
2864:
1067:
1051:
1038:
during cardiogenesis. ALC-2 expression in adult murine hearts is
608:
604:
5093:
5088:
5083:
5043:
5014:
4929:
4806:
4801:
4796:
4700:
4350:
4345:
4340:
4267:
4262:
4129:
4011:
4006:
4001:
3461:
3456:
3414:
3327:
3317:
3312:
3206:
3196:
3181:
3171:
3166:
3161:
3156:
3079:
3004:
2999:
2989:
2984:
2979:
2974:
2969:
2964:
1364:
1345:
1341:
1262:. Moreover, the slow force response induced by stretch in human
1162:
1146:
1138:
1098:
1079:
1035:
1003:
995:
952:
503:
63:
2795:
1006:, share 59% homology, showing significant differences at their
2582:"Mutation in myosin heavy chain 6 causes atrial septal defect"
2536:"Mutation in myosin heavy chain 6 causes atrial septal defect"
2650:
Kovács M, Wang F, Hu A, Zhang Y, Sellers JR (October 2003).
1314:, this change was concomitant with enhanced sensitivity of
1089:
ALC-2 and VLC-2 appear to function in the stabilization of
319:
1521:
Cardiac
Organellar Protein Atlas Knowledgebase (COPaKB)
1306:, ALC-2 was shown to be replaced with VLC-2 in cardiac
942:
Myosin regulatory light chain 2, atrial isoform (MLC2a)
1517:"Protein sequence of human MYL7 (Uniprot ID: Q01449)"
1503:"Entrez Gene: MYL7 myosin, light chain 7, regulatory"
1030:
ALC-2 expression has proven to be a useful marker of
484:
5061:
4960:
4866:
4821:
4730:
4709:
4661:
4484:
4276:
4228:
4080:
4066:
4032:
3979:
3948:
3928:
3807:
3689:
3520:
3502:
3491:
3434:
3227:
2906:
2863:
2854:
2840:
2833:
2729:
1046:days 8-16, and from day 12 and on is restricted to
854:
833:
807:
786:
1549:Winkelmann DA, Baker TS, Rayment I (August 1991).
1404:
1402:
1400:
1383:
1381:
1379:
1101:was overexpressed to replace the ALC-2 in cardiac
266:
165:
2205:Svensson C, Morano I, Arner A (November 1997).
2024:isoform reprogramming in atrial fibrillation".
1010:and at the regulatory phosphorylation site(s),
16:Protein-coding gene in the species Homo sapiens
1409:GRCm38: Ensembl release 89: ENSMUSG00000020469
1228:muscle strips showed an 80% increase in ALC-2
2807:
2528:
2526:
2402:Journal of the American College of Cardiology
2396:Lim DS, Roberts R, Marian AJ (October 2001).
2302:Circulation: Arrhythmia and Electrophysiology
1266:muscle was shown to be modulated by enhanced
1105:was performed. This substitution resulted in
1099:ventricular isoform of regulatory light chain
8:
2448:Journal of Molecular and Cellular Cardiology
1544:
1542:
2026:Journal of Cardiovascular Electrophysiology
1388:GRCh38: Ensembl release 89: ENSG00000106631
1169:, respectively. In a porcine model of left
4077:
3517:
3499:
2860:
2851:
2837:
2814:
2800:
2792:
1120:more forcefully and quickly, resulting in
619:
519:
307:
206:
103:
2773:
2702:
2687:"The human adult cardiomyocyte phenotype"
2667:
2632:
2597:
2551:
2506:
2421:
2372:
2323:
2313:
2271:
2222:
2181:
2171:
2130:
2120:
1999:
1958:
1917:
1840:
1756:
1637:
1574:
1478:
994:protein that binds to the neck region of
978:and others, ALC-2 expression is altered.
1344:, it was shown that binding of ALC-2 to
1255:was associated with decreased ALC-2 and
1216:level is around 30% of the total ALC-2.
1375:
20:
1180:Human ALC-2 is phosphorylated at its
1177:, VLC-2 was shown to be upregulated.
361:cardiac muscle tissue of right atrium
271:
232:
227:
170:
129:
124:
50:, MYL2A, MYLC2A, myosin light chain 7
7:
1149:expression is three times higher in
955:. ALC-2 expression is restricted to
2762:The Journal of Biological Chemistry
2656:The Journal of Biological Chemistry
2160:Molecular & Cellular Proteomics
2109:The Journal of Biological Chemistry
1829:The Journal of Biological Chemistry
1467:The Journal of Biological Chemistry
1919:10.1161/01.res.0000234807.16034.fe
1157:. Moreover, in a porcine model of
851:
830:
804:
783:
759:
740:
714:
695:
669:
650:
489:
407:
345:
324:
14:
1706:Trends in Cardiovascular Medicine
1244:inhibition. In a canine model of
948:that in humans is encoded by the
3442:Wiskott–Aldrich syndrome protein
2211:Journal of Cellular Biochemistry
2038:10.1046/j.1540-8167.2004.03423.x
493:
255:
248:
242:
219:
154:
147:
141:
116:
4663:Microtubule organising proteins
2634:10.1016/j.cardiores.2004.09.019
2273:10.1016/j.cardiores.2004.09.019
1218:Alpha(1)-adrenergic stimulation
966:. In human diseases, including
1782:Cytogenetics and Cell Genetics
1302:and pressure overload-induced
1236:, which was inhibited by both
504:More reference expression data
473:More reference expression data
397:right hemisphere of cerebellum
1:
4710:Microtubule severing proteins
2775:10.1016/S0021-9258(18)50090-9
2741:10.1016/S0006-291X(02)00640-X
2704:10.1016/S0008-6363(03)00253-0
2414:10.1016/s0735-1097(01)01509-1
1842:10.1016/S0021-9258(19)89483-8
1480:10.1016/S0021-9258(19)89483-8
1050:, showing very low levels in
240:
139:
3370:actin depolymerizing factors
2460:10.1016/0022-2828(90)90986-c
1325:In patients with congenital
1196:at position 14, which is an
938:Atrial Light Chain-2 (ALC-2)
385:myocardium of left ventricle
5134:EF-hand-containing proteins
5129:Genes on human chromosome 7
4848:Plakoglobin (gamma catenin)
1555:The Journal of Cell Biology
1284:hypertrophic cardiomyopathy
1139:ventricular isoform (VLC-2)
1074:patterning occurs prior to
968:hypertrophic cardiomyopathy
5150:
2082:10.1016/j.trsl.2014.11.005
1671:Stem Cells and Development
1626:Stem Cells and Development
1188:-15 by a cardiac-specific
5104:
2315:10.1161/circep.109.933036
1960:10.1161/01.cir.97.15.1508
1718:10.1016/j.tcm.2003.09.005
1444:"Mouse PubMed Reference:"
1426:"Human PubMed Reference:"
1272:myosin light chain kinase
1242:myosin light chain kinase
1232:coordinate with enhanced
1190:myosin light chain kinase
924:
919:
915:
908:
892:
873:
858:
837:
826:
811:
790:
779:
766:
762:
747:
743:
734:
721:
717:
702:
698:
689:
676:
672:
657:
653:
644:
629:
622:
618:
602:
522:
518:
501:
492:
483:
470:
419:
410:
357:
348:
318:
310:
306:
289:
276:
239:
218:
209:
205:
188:
175:
138:
115:
106:
102:
57:
54:
44:
37:
32:
28:
23:
5074:Prokaryotic cytoskeleton
2001:10.1161/01.res.62.6.1093
1346:alpha myosin heavy chain
1342:alpha myosin heavy chain
1257:myosin binding protein C
1080:alpha-myosin heavy chain
996:alpha myosin heavy chain
2691:Cardiovascular Research
2621:Cardiovascular Research
2487:The Biochemical Journal
2481:Cummins P (July 1982).
2353:Cardiovascular Research
2260:Cardiovascular Research
2173:10.1074/mcp.m110.000075
2122:10.1074/jbc.m110.160499
1867:Cardiovascular Research
1292:ischemic cardiomyopathy
1086:of non-human primates.
976:ischemic cardiomyopathy
879:Chr 7: 44.14 – 44.14 Mb
439:interventricular septum
2669:10.1074/jbc.M305453200
2070:Translational Research
1312:dilated cardiomyopathy
1300:coronary heart disease
1296:dilated cardiomyopathy
972:dilated cardiomyopathy
886:Chr 11: 5.85 – 5.85 Mb
427:atrioventricular valve
3694:(hard alpha-keratins)
3525:(soft alpha-keratins)
1745:The Anatomical Record
1683:10.1089/scd.2011.0254
1648:10.1089/scd.2014.0195
1603:Uniprot Knowledgebase
1567:10.1083/jcb.114.4.701
1278:Clinical Significance
1173:remodeling following
1042:-specific throughout
273:11 A1|11 3.88 cM
234:Chromosome 11 (mouse)
5109:cytoskeletal defects
5069:Major sperm proteins
1988:Circulation Research
1906:Circulation Research
1879:10.1093/cvr/27.3.416
1527:on 24 September 2015
1327:atrial septal defect
1288:mitral valve disease
1175:mitral regurgitation
1054:and undetectable in
132:Chromosome 7 (human)
3522:Epithelial keratins
1304:cardiac hypertrophy
1246:atrial fibrillation
1159:atrial fibrillation
1155:cardiac hypertrophy
1141:. In spontaneously
537:calcium ion binding
431:endocardial cushion
2365:10.1093/cvr/cvn126
1356:ALC-2 is shown to
1093:and regulation of
724:ENSMUSG00000020469
594:muscle contraction
587:Biological process
556:Cellular component
530:Molecular function
389:anterior pituitary
5116:
5115:
5057:
5056:
4817:
4816:
4062:
4061:
3944:
3943:
3487:
3486:
3430:
3429:
2768:(32): 23295–300.
2499:10.1042/bj2050195
1794:10.1159/000056782
1331:missense mutation
1234:contractile force
935:
934:
931:
930:
904:
903:
869:
868:
848:
847:
822:
821:
801:
800:
775:
774:
756:
755:
730:
729:
711:
710:
685:
684:
666:
665:
614:
613:
547:metal ion binding
514:
513:
510:
509:
479:
478:
466:
465:
404:
403:
302:
301:
201:
200:
5141:
4078:
3518:
3500:
2861:
2852:
2838:
2816:
2809:
2802:
2793:
2787:
2777:
2752:
2726:
2716:
2706:
2681:
2671:
2662:(40): 38132–40.
2646:
2636:
2611:
2601:
2566:
2565:
2555:
2530:
2521:
2520:
2510:
2478:
2472:
2471:
2442:
2436:
2435:
2425:
2393:
2387:
2386:
2376:
2344:
2338:
2337:
2327:
2317:
2292:
2286:
2285:
2275:
2251:
2245:
2244:
2226:
2202:
2196:
2195:
2185:
2175:
2151:
2145:
2144:
2134:
2124:
2115:(52): 40819–29.
2100:
2094:
2093:
2064:
2058:
2057:
2020:
2014:
2013:
2003:
1979:
1973:
1972:
1962:
1938:
1932:
1931:
1921:
1897:
1891:
1890:
1861:
1855:
1854:
1844:
1835:(24): 16961–70.
1820:
1814:
1813:
1777:
1771:
1770:
1760:
1736:
1730:
1729:
1701:
1695:
1694:
1666:
1660:
1659:
1641:
1639:10.1.1.1012.2726
1620:
1614:
1613:
1611:
1609:
1595:
1589:
1588:
1578:
1546:
1537:
1536:
1534:
1532:
1523:. Archived from
1513:
1507:
1506:
1499:
1493:
1492:
1482:
1473:(24): 16961–70.
1458:
1452:
1451:
1440:
1434:
1433:
1422:
1416:
1406:
1395:
1385:
998:. ALC-2 and the
917:
916:
888:
881:
864:
852:
843:
831:
827:RefSeq (protein)
817:
805:
796:
784:
760:
741:
715:
696:
670:
651:
620:
520:
506:
497:
490:
475:
415:
413:Top expressed in
408:
353:
351:Top expressed in
346:
325:
308:
298:
285:
274:
259:
252:
246:
235:
223:
207:
197:
184:
173:
158:
151:
145:
134:
120:
104:
98:
96:MYL7 - orthologs
49:
42:
21:
5149:
5148:
5144:
5143:
5142:
5140:
5139:
5138:
5119:
5118:
5117:
5112:
5100:
5053:
4956:
4862:
4813:
4726:
4705:
4657:
4480:
4272:
4224:
4070:
4058:
4028:
3975:
3940:
3924:
3808:Ungrouped alpha
3803:
3693:
3685:
3524:
3510:
3504:
3494:
3483:
3426:
3223:
2902:
2844:
2829:
2820:
2790:
2755:
2724:
2719:
2684:
2649:
2614:
2586:Nature Genetics
2578:
2574:
2572:Further reading
2569:
2540:Nature Genetics
2532:
2531:
2524:
2480:
2479:
2475:
2454:(12): 1425–38.
2444:
2443:
2439:
2395:
2394:
2390:
2346:
2345:
2341:
2294:
2293:
2289:
2253:
2252:
2248:
2204:
2203:
2199:
2153:
2152:
2148:
2102:
2101:
2097:
2066:
2065:
2061:
2022:
2021:
2017:
1981:
1980:
1976:
1953:(15): 1508–13.
1940:
1939:
1935:
1899:
1898:
1894:
1863:
1862:
1858:
1822:
1821:
1817:
1788:(3–4): 248–52.
1779:
1778:
1774:
1738:
1737:
1733:
1703:
1702:
1698:
1668:
1667:
1663:
1622:
1621:
1617:
1607:
1605:
1597:
1596:
1592:
1548:
1547:
1540:
1530:
1528:
1515:
1514:
1510:
1501:
1500:
1496:
1460:
1459:
1455:
1442:
1441:
1437:
1424:
1423:
1419:
1407:
1398:
1386:
1377:
1373:
1354:
1280:
1268:phosphorylation
1260:phosphorylation
1230:phosphorylation
1214:phosphorylation
1206:phosphorylation
1127:that behave as
1091:thick filaments
1060:skeletal muscle
1028:
984:
926:View/Edit Mouse
921:View/Edit Human
884:
877:
874:Location (UCSC)
860:
839:
813:
792:
705:ENSG00000106631
598:
582:
568:dendritic spine
551:
542:protein binding
502:
471:
462:
457:
455:right lung lobe
453:
449:
445:
441:
437:
433:
429:
425:
411:
400:
395:
391:
387:
383:
381:right ventricle
379:
375:
371:
367:
363:
349:
293:
280:
272:
262:
261:
260:
253:
233:
210:Gene location (
192:
179:
171:
161:
160:
159:
152:
130:
107:Gene location (
58:
45:
38:
17:
12:
11:
5:
5147:
5145:
5137:
5136:
5131:
5121:
5120:
5114:
5113:
5105:
5102:
5101:
5099:
5098:
5097:
5096:
5091:
5086:
5081:
5071:
5065:
5063:
5059:
5058:
5055:
5054:
5052:
5051:
5046:
5041:
5040:
5039:
5034:
5024:
5019:
5018:
5017:
5007:
5006:
5005:
5000:
4995:
4990:
4985:
4980:
4975:
4973:Corneodesmosin
4964:
4962:
4958:
4957:
4955:
4954:
4953:
4952:
4947:
4942:
4937:
4932:
4927:
4922:
4912:
4911:
4910:
4905:
4900:
4890:
4885:
4884:
4883:
4872:
4870:
4864:
4863:
4861:
4860:
4855:
4850:
4845:
4844:
4843:
4833:
4827:
4825:
4819:
4818:
4815:
4814:
4812:
4811:
4810:
4809:
4804:
4799:
4789:
4788:
4787:
4782:
4777:
4772:
4767:
4757:
4752:
4751:
4750:
4740:
4734:
4732:
4728:
4727:
4725:
4724:
4719:
4713:
4711:
4707:
4706:
4704:
4703:
4698:
4693:
4688:
4683:
4678:
4673:
4667:
4665:
4659:
4658:
4656:
4655:
4650:
4645:
4640:
4635:
4630:
4625:
4620:
4615:
4610:
4605:
4600:
4595:
4588:
4587:
4582:
4577:
4572:
4567:
4562:
4557:
4552:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4512:
4507:
4502:
4497:
4490:
4488:
4482:
4481:
4479:
4478:
4473:
4468:
4463:
4458:
4453:
4448:
4443:
4438:
4433:
4428:
4423:
4418:
4413:
4408:
4403:
4398:
4393:
4388:
4383:
4378:
4373:
4368:
4363:
4358:
4353:
4348:
4343:
4338:
4333:
4328:
4323:
4318:
4313:
4308:
4303:
4298:
4293:
4288:
4282:
4280:
4274:
4273:
4271:
4270:
4265:
4260:
4255:
4250:
4245:
4240:
4234:
4232:
4226:
4225:
4223:
4222:
4217:
4212:
4207:
4202:
4197:
4192:
4187:
4182:
4177:
4172:
4167:
4162:
4157:
4152:
4147:
4142:
4137:
4132:
4127:
4122:
4117:
4112:
4107:
4102:
4097:
4092:
4086:
4084:
4075:
4064:
4063:
4060:
4059:
4057:
4056:
4051:
4046:
4040:Nuclear lamins
4036:
4034:
4030:
4029:
4027:
4026:
4021:
4016:
4015:
4014:
4009:
4004:
3994:
3989:
3983:
3981:
3977:
3976:
3974:
3973:
3968:
3963:
3958:
3952:
3950:
3946:
3945:
3942:
3941:
3939:
3938:
3932:
3930:
3926:
3925:
3923:
3922:
3921:
3920:
3915:
3910:
3905:
3900:
3895:
3890:
3885:
3880:
3875:
3862:
3861:
3860:
3859:
3854:
3849:
3844:
3839:
3834:
3829:
3824:
3811:
3809:
3805:
3804:
3802:
3801:
3800:
3799:
3794:
3789:
3784:
3779:
3774:
3757:
3756:
3755:
3754:
3749:
3744:
3739:
3734:
3729:
3724:
3719:
3714:
3697:
3695:
3687:
3686:
3684:
3683:
3682:
3681:
3676:
3671:
3666:
3661:
3656:
3651:
3646:
3641:
3636:
3619:
3618:
3617:
3616:
3606:
3605:
3604:
3592:
3591:
3590:
3585:
3580:
3575:
3570:
3565:
3560:
3555:
3550:
3545:
3528:
3526:
3515:
3497:
3489:
3488:
3485:
3484:
3482:
3481:
3476:
3471:
3470:
3469:
3464:
3459:
3449:
3444:
3438:
3436:
3432:
3431:
3428:
3427:
3425:
3424:
3419:
3418:
3417:
3412:
3402:
3397:
3396:
3395:
3390:
3389:
3388:
3383:
3366:
3364:Arp2/3 complex
3361:
3360:
3359:
3354:
3349:
3344:
3333:
3332:
3331:
3330:
3325:
3320:
3315:
3305:
3304:
3303:
3289:
3278:
3259:
3258:
3257:
3252:
3247:
3242:
3231:
3229:
3225:
3224:
3222:
3221:
3220:
3219:
3214:
3209:
3204:
3199:
3194:
3189:
3184:
3179:
3174:
3169:
3164:
3159:
3149:
3148:
3147:
3142:
3134:
3133:
3132:
3124:
3123:
3122:
3114:
3113:
3112:
3107:
3099:
3098:
3097:
3092:
3084:
3083:
3082:
3074:
3073:
3072:
3067:
3062:
3054:
3053:
3052:
3047:
3039:
3038:
3037:
3032:
3027:
3022:
3017:
3012:
3007:
3002:
2997:
2992:
2987:
2982:
2977:
2972:
2967:
2959:
2958:
2957:
2951:
2946:
2941:
2936:
2931:
2926:
2921:
2912:
2910:
2904:
2903:
2901:
2900:
2895:
2890:
2885:
2880:
2875:
2869:
2867:
2858:
2849:
2842:Microfilaments
2835:
2831:
2830:
2821:
2819:
2818:
2811:
2804:
2796:
2789:
2788:
2753:
2717:
2682:
2647:
2612:
2599:10.1038/ng1526
2575:
2573:
2570:
2568:
2567:
2553:10.1038/ng1526
2522:
2493:(1): 195–204.
2473:
2437:
2408:(4): 1175–80.
2388:
2339:
2287:
2246:
2197:
2166:(9): 1804–18.
2146:
2095:
2076:(5): 599–620.
2059:
2015:
1974:
1933:
1892:
1856:
1815:
1772:
1731:
1696:
1677:(9): 1513–23.
1661:
1615:
1590:
1538:
1508:
1494:
1453:
1435:
1417:
1396:
1374:
1372:
1369:
1368:
1367:
1353:
1350:
1348:is disrupted.
1282:Patients with
1279:
1276:
1192:; ALC-2 has a
1132:cardiomyocytes
1125:cardiomyocytes
1032:cardiac muscle
1027:
1024:
983:
980:
957:cardiac muscle
940:also known as
933:
932:
929:
928:
923:
913:
912:
906:
905:
902:
901:
899:
897:
890:
889:
882:
875:
871:
870:
867:
866:
856:
855:
849:
846:
845:
835:
834:
828:
824:
823:
820:
819:
809:
808:
802:
799:
798:
788:
787:
781:
777:
776:
773:
772:
764:
763:
757:
754:
753:
745:
744:
738:
732:
731:
728:
727:
719:
718:
712:
709:
708:
700:
699:
693:
687:
686:
683:
682:
674:
673:
667:
664:
663:
655:
654:
648:
642:
641:
636:
631:
627:
626:
616:
615:
612:
611:
600:
599:
597:
596:
590:
588:
584:
583:
581:
580:
578:myosin complex
575:
570:
565:
559:
557:
553:
552:
550:
549:
544:
539:
533:
531:
527:
526:
516:
515:
512:
511:
508:
507:
499:
498:
487:
481:
480:
477:
476:
468:
467:
464:
463:
461:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
417:
416:
405:
402:
401:
399:
398:
394:
390:
386:
382:
378:
377:left ventricle
374:
370:
366:
362:
358:
355:
354:
342:
341:
333:
322:
316:
315:
312:RNA expression
304:
303:
300:
299:
291:
287:
286:
278:
275:
270:
264:
263:
254:
247:
241:
237:
236:
231:
225:
224:
216:
215:
203:
202:
199:
198:
190:
186:
185:
177:
174:
169:
163:
162:
153:
146:
140:
136:
135:
128:
122:
121:
113:
112:
100:
99:
56:
52:
51:
43:
35:
34:
30:
29:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
5146:
5135:
5132:
5130:
5127:
5126:
5124:
5111:
5110:
5103:
5095:
5092:
5090:
5087:
5085:
5082:
5080:
5077:
5076:
5075:
5072:
5070:
5067:
5066:
5064:
5060:
5050:
5047:
5045:
5042:
5038:
5035:
5033:
5030:
5029:
5028:
5025:
5023:
5020:
5016:
5013:
5012:
5011:
5008:
5004:
5001:
4999:
4996:
4994:
4991:
4989:
4986:
4984:
4981:
4979:
4976:
4974:
4971:
4970:
4969:
4966:
4965:
4963:
4959:
4951:
4948:
4946:
4943:
4941:
4938:
4936:
4933:
4931:
4928:
4926:
4923:
4921:
4918:
4917:
4916:
4913:
4909:
4906:
4904:
4901:
4899:
4896:
4895:
4894:
4891:
4889:
4886:
4882:
4879:
4878:
4877:
4874:
4873:
4871:
4869:
4865:
4859:
4856:
4854:
4853:Delta catenin
4851:
4849:
4846:
4842:
4839:
4838:
4837:
4834:
4832:
4831:Alpha catenin
4829:
4828:
4826:
4824:
4820:
4808:
4805:
4803:
4800:
4798:
4795:
4794:
4793:
4790:
4786:
4783:
4781:
4778:
4776:
4773:
4771:
4768:
4766:
4763:
4762:
4761:
4758:
4756:
4753:
4749:
4746:
4745:
4744:
4741:
4739:
4736:
4735:
4733:
4729:
4723:
4720:
4718:
4715:
4714:
4712:
4708:
4702:
4699:
4697:
4694:
4692:
4689:
4687:
4684:
4682:
4679:
4677:
4674:
4672:
4669:
4668:
4666:
4664:
4660:
4654:
4651:
4649:
4646:
4644:
4641:
4639:
4636:
4634:
4631:
4629:
4626:
4624:
4621:
4619:
4616:
4614:
4611:
4609:
4606:
4604:
4601:
4599:
4596:
4594:
4591:cytoplasmic:
4590:
4589:
4586:
4583:
4581:
4578:
4576:
4573:
4571:
4568:
4566:
4563:
4561:
4558:
4556:
4553:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4516:
4513:
4511:
4508:
4506:
4503:
4501:
4498:
4496:
4492:
4491:
4489:
4487:
4483:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4457:
4454:
4452:
4449:
4447:
4444:
4442:
4439:
4437:
4434:
4432:
4429:
4427:
4424:
4422:
4419:
4417:
4414:
4412:
4409:
4407:
4404:
4402:
4399:
4397:
4394:
4392:
4389:
4387:
4384:
4382:
4379:
4377:
4374:
4372:
4369:
4367:
4364:
4362:
4359:
4357:
4354:
4352:
4349:
4347:
4344:
4342:
4339:
4337:
4334:
4332:
4329:
4327:
4324:
4322:
4319:
4317:
4314:
4312:
4309:
4307:
4304:
4302:
4299:
4297:
4294:
4292:
4289:
4287:
4284:
4283:
4281:
4279:
4275:
4269:
4266:
4264:
4261:
4259:
4256:
4254:
4251:
4249:
4246:
4244:
4241:
4239:
4236:
4235:
4233:
4231:
4227:
4221:
4218:
4216:
4213:
4211:
4208:
4206:
4203:
4201:
4198:
4196:
4193:
4191:
4188:
4186:
4183:
4181:
4178:
4176:
4173:
4171:
4168:
4166:
4163:
4161:
4158:
4156:
4153:
4151:
4148:
4146:
4143:
4141:
4138:
4136:
4133:
4131:
4128:
4126:
4123:
4121:
4118:
4116:
4113:
4111:
4108:
4106:
4103:
4101:
4098:
4096:
4093:
4091:
4088:
4087:
4085:
4083:
4079:
4076:
4074:
4069:
4065:
4055:
4052:
4050:
4047:
4045:
4041:
4038:
4037:
4035:
4031:
4025:
4022:
4020:
4017:
4013:
4010:
4008:
4005:
4003:
4000:
3999:
3998:
3997:Neurofilament
3995:
3993:
3990:
3988:
3985:
3984:
3982:
3978:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3953:
3951:
3947:
3937:
3934:
3933:
3931:
3927:
3919:
3916:
3914:
3911:
3909:
3906:
3904:
3901:
3899:
3896:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3876:
3874:
3871:
3870:
3869:
3868:
3867:chromosome 12
3864:
3863:
3858:
3855:
3853:
3850:
3848:
3845:
3843:
3840:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3819:
3818:
3817:
3816:chromosome 17
3813:
3812:
3810:
3806:
3798:
3795:
3793:
3790:
3788:
3785:
3783:
3780:
3778:
3775:
3773:
3770:
3769:
3768:
3767:
3766:chromosome 12
3763:
3759:
3758:
3753:
3750:
3748:
3745:
3743:
3740:
3738:
3735:
3733:
3730:
3728:
3725:
3723:
3720:
3718:
3715:
3713:
3710:
3709:
3708:
3707:
3706:chromosome 17
3703:
3699:
3698:
3696:
3692:
3691:Hair keratins
3688:
3680:
3677:
3675:
3672:
3670:
3667:
3665:
3662:
3660:
3657:
3655:
3652:
3650:
3647:
3645:
3642:
3640:
3637:
3635:
3632:
3631:
3630:
3629:
3628:chromosome 12
3625:
3621:
3620:
3615:
3612:
3611:
3610:
3607:
3603:
3600:
3599:
3598:
3597:
3596:chromosome 12
3593:
3589:
3586:
3584:
3581:
3579:
3576:
3574:
3571:
3569:
3566:
3564:
3561:
3559:
3556:
3554:
3551:
3549:
3546:
3544:
3541:
3540:
3539:
3538:
3537:chromosome 17
3534:
3530:
3529:
3527:
3523:
3519:
3516:
3513:
3508:
3501:
3498:
3496:
3493:Intermediate
3490:
3480:
3477:
3475:
3472:
3468:
3465:
3463:
3460:
3458:
3455:
3454:
3453:
3450:
3448:
3445:
3443:
3440:
3439:
3437:
3433:
3423:
3420:
3416:
3413:
3411:
3408:
3407:
3406:
3403:
3401:
3398:
3394:
3391:
3387:
3384:
3382:
3379:
3378:
3377:
3374:
3373:
3372:
3371:
3367:
3365:
3362:
3358:
3355:
3353:
3350:
3348:
3345:
3343:
3340:
3339:
3338:
3335:
3334:
3329:
3326:
3324:
3321:
3319:
3316:
3314:
3311:
3310:
3309:
3306:
3302:
3299:
3296:
3293:
3290:
3288:
3285:
3282:
3279:
3277:
3274:
3271:
3268:
3265:
3264:
3263:
3260:
3256:
3253:
3251:
3248:
3246:
3243:
3241:
3238:
3237:
3236:
3233:
3232:
3230:
3226:
3218:
3215:
3213:
3210:
3208:
3205:
3203:
3200:
3198:
3195:
3193:
3190:
3188:
3185:
3183:
3180:
3178:
3175:
3173:
3170:
3168:
3165:
3163:
3160:
3158:
3155:
3154:
3153:
3150:
3146:
3143:
3141:
3138:
3137:
3135:
3131:
3128:
3127:
3125:
3121:
3118:
3117:
3115:
3111:
3108:
3106:
3103:
3102:
3100:
3096:
3093:
3091:
3088:
3087:
3085:
3081:
3078:
3077:
3075:
3071:
3068:
3066:
3063:
3061:
3058:
3057:
3055:
3051:
3048:
3046:
3043:
3042:
3040:
3036:
3033:
3031:
3028:
3026:
3023:
3021:
3018:
3016:
3013:
3011:
3008:
3006:
3003:
3001:
2998:
2996:
2993:
2991:
2988:
2986:
2983:
2981:
2978:
2976:
2973:
2971:
2968:
2966:
2963:
2962:
2960:
2955:
2952:
2950:
2947:
2945:
2942:
2940:
2937:
2935:
2932:
2930:
2927:
2925:
2922:
2920:
2917:
2916:
2914:
2913:
2911:
2909:
2905:
2899:
2896:
2894:
2891:
2889:
2886:
2884:
2881:
2879:
2876:
2874:
2871:
2870:
2868:
2866:
2862:
2859:
2857:
2853:
2850:
2848:
2843:
2839:
2836:
2832:
2828:
2824:
2817:
2812:
2810:
2805:
2803:
2798:
2797:
2794:
2785:
2781:
2776:
2771:
2767:
2763:
2759:
2754:
2750:
2746:
2742:
2738:
2734:
2730:
2723:
2718:
2714:
2710:
2705:
2700:
2697:(2): 423–34.
2696:
2692:
2688:
2683:
2679:
2675:
2670:
2665:
2661:
2657:
2653:
2648:
2644:
2640:
2635:
2630:
2627:(1): 211–20.
2626:
2622:
2618:
2613:
2609:
2605:
2600:
2595:
2591:
2587:
2583:
2577:
2576:
2571:
2563:
2559:
2554:
2549:
2545:
2541:
2537:
2529:
2527:
2523:
2518:
2514:
2509:
2504:
2500:
2496:
2492:
2488:
2484:
2477:
2474:
2469:
2465:
2461:
2457:
2453:
2449:
2441:
2438:
2433:
2429:
2424:
2419:
2415:
2411:
2407:
2403:
2399:
2392:
2389:
2384:
2380:
2375:
2370:
2366:
2362:
2359:(4): 642–51.
2358:
2354:
2350:
2343:
2340:
2335:
2331:
2326:
2321:
2316:
2311:
2308:(5): 530–41.
2307:
2303:
2299:
2291:
2288:
2283:
2279:
2274:
2269:
2266:(1): 211–20.
2265:
2261:
2257:
2250:
2247:
2242:
2238:
2234:
2230:
2225:
2220:
2216:
2212:
2208:
2201:
2198:
2193:
2189:
2184:
2179:
2174:
2169:
2165:
2161:
2157:
2150:
2147:
2142:
2138:
2133:
2128:
2123:
2118:
2114:
2110:
2106:
2099:
2096:
2091:
2087:
2083:
2079:
2075:
2071:
2063:
2060:
2055:
2051:
2047:
2043:
2039:
2035:
2032:(2): 214–23.
2031:
2027:
2019:
2016:
2011:
2007:
2002:
1997:
1994:(6): 1093–7.
1993:
1989:
1985:
1978:
1975:
1970:
1966:
1961:
1956:
1952:
1948:
1944:
1937:
1934:
1929:
1925:
1920:
1915:
1912:(3): 323–31.
1911:
1907:
1903:
1896:
1893:
1888:
1884:
1880:
1876:
1873:(3): 416–22.
1872:
1868:
1860:
1857:
1852:
1848:
1843:
1838:
1834:
1830:
1826:
1819:
1816:
1811:
1807:
1803:
1799:
1795:
1791:
1787:
1783:
1776:
1773:
1768:
1764:
1759:
1754:
1751:(1): 135–46.
1750:
1746:
1742:
1735:
1732:
1727:
1723:
1719:
1715:
1711:
1707:
1700:
1697:
1692:
1688:
1684:
1680:
1676:
1672:
1665:
1662:
1657:
1653:
1649:
1645:
1640:
1635:
1631:
1627:
1619:
1616:
1604:
1600:
1594:
1591:
1586:
1582:
1577:
1572:
1568:
1564:
1561:(4): 701–13.
1560:
1556:
1552:
1545:
1543:
1539:
1526:
1522:
1518:
1512:
1509:
1504:
1498:
1495:
1490:
1486:
1481:
1476:
1472:
1468:
1464:
1457:
1454:
1449:
1445:
1439:
1436:
1431:
1427:
1421:
1418:
1414:
1410:
1405:
1403:
1401:
1397:
1393:
1389:
1384:
1382:
1380:
1376:
1370:
1366:
1363:
1362:
1361:
1359:
1351:
1349:
1347:
1343:
1339:
1335:
1332:
1328:
1323:
1321:
1317:
1313:
1309:
1305:
1301:
1297:
1293:
1289:
1285:
1277:
1275:
1273:
1269:
1265:
1261:
1258:
1254:
1253:contractility
1251:
1247:
1243:
1239:
1235:
1231:
1227:
1223:
1222:phenylephrine
1219:
1215:
1211:
1207:
1203:
1199:
1195:
1191:
1187:
1183:
1178:
1176:
1172:
1168:
1164:
1160:
1156:
1152:
1148:
1144:
1140:
1135:
1133:
1130:
1126:
1123:
1119:
1115:
1111:
1108:
1104:
1100:
1096:
1095:contractility
1092:
1087:
1085:
1084:cardiac atria
1081:
1077:
1073:
1069:
1065:
1061:
1057:
1053:
1049:
1045:
1041:
1037:
1033:
1025:
1023:
1021:
1017:
1013:
1009:
1005:
1001:
997:
993:
989:
981:
979:
977:
973:
969:
965:
964:contractility
961:
958:
954:
951:
947:
943:
939:
927:
922:
918:
914:
911:
907:
900:
898:
895:
891:
887:
883:
880:
876:
872:
865:
863:
857:
853:
850:
844:
842:
836:
832:
829:
825:
818:
816:
810:
806:
803:
797:
795:
789:
785:
782:
780:RefSeq (mRNA)
778:
771:
770:
765:
761:
758:
752:
751:
746:
742:
739:
737:
733:
726:
725:
720:
716:
713:
707:
706:
701:
697:
694:
692:
688:
681:
680:
675:
671:
668:
662:
661:
656:
652:
649:
647:
643:
640:
637:
635:
632:
628:
625:
621:
617:
610:
606:
601:
595:
592:
591:
589:
586:
585:
579:
576:
574:
571:
569:
566:
564:
561:
560:
558:
555:
554:
548:
545:
543:
540:
538:
535:
534:
532:
529:
528:
525:
524:Gene ontology
521:
517:
505:
500:
496:
491:
488:
486:
482:
474:
469:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
396:
392:
388:
384:
380:
376:
372:
369:apex of heart
368:
365:right auricle
364:
360:
359:
356:
352:
347:
344:
343:
340:
338:
334:
332:
331:
327:
326:
323:
321:
317:
313:
309:
305:
297:
292:
288:
284:
279:
269:
265:
258:
251:
245:
238:
230:
226:
222:
217:
213:
208:
204:
196:
191:
187:
183:
178:
168:
164:
157:
150:
144:
137:
133:
127:
123:
119:
114:
110:
105:
101:
97:
93:
89:
85:
81:
77:
73:
69:
65:
61:
53:
48:
41:
36:
31:
27:
22:
19:
5106:
4881:Dystroglycan
4836:Beta catenin
4068:Microtubules
3936:Beta-keratin
3865:
3814:
3760:
3700:
3622:
3608:
3594:
3531:
3368:
3235:Tropomodulin
3191:
2827:cytoskeleton
2765:
2761:
2735:(1): 112–8.
2732:
2728:
2694:
2690:
2659:
2655:
2624:
2620:
2592:(4): 423–8.
2589:
2585:
2546:(4): 423–8.
2543:
2539:
2490:
2486:
2476:
2451:
2447:
2440:
2405:
2401:
2391:
2356:
2352:
2342:
2305:
2301:
2290:
2263:
2259:
2249:
2217:(2): 241–7.
2214:
2210:
2200:
2163:
2159:
2149:
2112:
2108:
2098:
2073:
2069:
2062:
2029:
2025:
2018:
1991:
1987:
1977:
1950:
1946:
1936:
1909:
1905:
1895:
1870:
1866:
1859:
1832:
1828:
1818:
1785:
1781:
1775:
1748:
1744:
1734:
1709:
1705:
1699:
1674:
1670:
1664:
1632:(1): 11–20.
1629:
1625:
1618:
1606:. Retrieved
1602:
1593:
1558:
1554:
1529:. Retrieved
1525:the original
1520:
1511:
1497:
1470:
1466:
1456:
1447:
1438:
1429:
1420:
1355:
1352:Interactions
1324:
1281:
1270:of ALC-2 by
1248:, decreased
1179:
1145:rats, VLC-2
1143:hypertensive
1136:
1088:
1029:
986:Human ALC-2
985:
949:
941:
937:
936:
859:
838:
812:
791:
767:
748:
722:
703:
677:
658:
638:
633:
443:right atrium
435:aortic valve
335:
328:
55:External IDs
18:
5027:Plakophilin
4978:Desmoplakin
4738:Tau protein
3512:Cytokeratin
3308:Tropomyosin
2856:Myofilament
1947:Circulation
1712:(1): 13–8.
1329:carrying a
1208:). Whether
1202:ventricular
1129:ventricular
1000:ventricular
451:left atrium
193:44,141,332
180:44,138,864
33:Identifiers
5123:Categories
5107:See also:
5079:Crescentin
4998:Periplakin
4988:Envoplakin
4876:Dystrophin
4493:axonemal:
3987:Internexin
3966:Peripherin
2325:1871/20882
1415:, May 2017
1394:, May 2017
1371:References
1318:fibers to
1238:Rho kinase
1198:Asparagine
1182:N-terminus
1056:ventricles
1020:Asparagine
447:right lung
339:(ortholog)
294:5,848,782
281:5,846,637
76:HomoloGene
4696:Centrin 3
4691:Centrin 2
4686:Centrin 1
4024:Syncoilin
3929:Not alpha
3495:filaments
3447:Fibrillin
1634:CiteSeerX
1076:septation
1044:embryonic
1008:N-termini
1002:isoform,
982:Structure
862:NP_075017
841:NP_067046
815:NM_022879
794:NM_021223
624:Orthologs
459:left lung
373:vena cava
84:GeneCards
5062:Nonhuman
5022:Vinculin
4983:Dystonin
4915:Spectrin
4888:Utrophin
4868:Membrane
4823:Catenins
4755:Stathmin
4743:Dynactin
4623:DYNC2LI1
4618:DYNC1LI2
4613:DYNC1LI1
4278:Kinesins
4082:Tubulins
3971:Vimentin
3503:Type 1/2
3405:Profilin
3400:Gelsolin
3262:Troponin
2823:Proteins
2749:12083776
2713:12757876
2678:12847096
2643:15621049
2608:15735645
2562:15735645
2432:11583900
2383:18503051
2334:20660541
2282:15621049
2241:25471259
2192:20445002
2141:20943660
2090:25500755
2054:33458242
2046:15028053
1928:16809551
1810:30832032
1802:11124527
1726:14720469
1691:21933026
1656:25075536
1411:–
1390:–
1358:interact
1161:, VLC-2
1114:contract
1110:myocytes
1026:Function
1014:-15 and
910:Wikidata
603:Sources:
5049:PLEKHA7
5003:Plectin
4968:Plakins
4893:Ankyrin
4792:Dynamin
4722:Spastin
4717:Katanin
4681:CAMSAP3
4676:CAMSAP2
4671:CAMSAP1
4643:DYNLRB2
4638:DYNLRB1
4608:DYNC1I2
4603:DYNC1I1
4598:DYNC2H1
4593:DYNC1H1
4486:Dyneins
4210:TUBGCP6
4205:TUBGCP5
4200:TUBGCP4
4195:TUBGCP3
4190:TUBGCP2
4019:Synemin
3762:type II
3624:type II
3507:Keratin
3452:Filamin
3393:Destrin
3376:Cofilin
3337:Actinin
2908:Myosins
2825:of the
2784:1429676
2517:6215032
2508:1158463
2468:2089158
2423:2776821
2374:2614393
2233:9328829
2183:2938104
2132:3003383
2010:3383359
1969:9576432
1887:8490941
1851:8207020
1767:9892427
1608:30 June
1585:1869586
1576:2289899
1531:30 June
1489:8207020
1413:Ensembl
1392:Ensembl
1320:calcium
1200:in the
1070:. This
1040:cardiac
1036:(ALC-1)
992:EF hand
988:protein
946:protein
736:UniProt
691:Ensembl
630:Species
609:QuickGO
563:cytosol
314:pattern
40:Aliases
4950:SPTBN5
4945:SPTBN4
4940:SPTBN2
4935:SPTBN1
4925:SPTAN1
4760:Tektin
4653:DYNLT3
4648:DYNLT1
4633:DYNLL2
4628:DYNLL1
4575:DNALI1
4560:DNAH17
4555:DNAH14
4550:DNAH13
4545:DNAH12
4540:DNAH11
4535:DNAH10
4456:KIF26B
4451:KIF26A
4426:KIF21B
4421:KIF21A
4416:KIF20B
4411:KIF20A
4401:KIF18B
4396:KIF18A
4386:KIF16B
4371:KIF13B
4366:KIF13A
4165:TUBB4Q
4150:TUBB2C
4145:TUBB2B
4140:TUBB2A
4120:TUBA4A
4115:TUBA3E
4110:TUBA3D
4105:TUBA3C
4100:TUBA1C
4095:TUBA1B
4090:TUBA1A
4033:Type 5
3992:Nestin
3980:Type 4
3956:Desmin
3949:Type 3
3702:type I
3533:type I
3479:TRIOBP
3145:MYO18B
3140:MYO18A
3136:XVIII
3130:MYO15A
2865:Actins
2782:
2747:
2711:
2676:
2641:
2606:
2560:
2515:
2505:
2466:
2430:
2420:
2381:
2371:
2332:
2280:
2239:
2231:
2190:
2180:
2139:
2129:
2088:
2052:
2044:
2008:
1967:
1926:
1885:
1849:
1808:
1800:
1765:
1724:
1689:
1654:
1636:
1583:
1573:
1487:
1360:with:
1316:atrial
1264:atrial
1250:atrial
1226:atrial
1210:serine
1194:serine
1186:Serine
1171:atrial
1122:atrial
1107:atrial
1072:atrial
1066:, and
1064:uterus
1016:Serine
1012:Serine
896:search
894:PubMed
769:Q9QVP4
750:Q01449
646:Entrez
573:A band
485:BioGPS
423:atrium
72:107495
64:613993
5010:Talin
4993:MACF1
4961:Other
4920:SPTA1
4785:TEKT5
4780:TEKT4
4775:TEKT3
4770:TEKT2
4765:TEKT1
4748:DCTN1
4731:Other
4585:DNAL4
4580:DNAL1
4570:DNAI2
4565:DNAI1
4530:DNAH9
4525:DNAH8
4520:DNAH7
4515:DNAH6
4510:DNAH5
4505:DNAH3
4500:DNAH2
4495:DNAH1
4476:KIFC3
4471:KIFC2
4466:KIFC1
4461:KIF27
4446:KIF25
4441:KIF24
4436:KIF23
4431:KIF22
4406:KIF19
4391:KIF17
4381:KIF15
4376:KIF14
4361:KIF12
4356:KIF11
4336:KIF5C
4331:KIF5B
4326:KIF5A
4321:KIF4B
4316:KIF4A
4311:KIF3C
4306:KIF3B
4301:KIF2C
4296:KIF2A
4291:KIF1B
4286:KIF1A
4258:MAP1B
4253:MAP1A
4220:TUBE1
4215:TUBD1
4185:TUBG2
4180:TUBG1
4175:TUBB8
4170:TUBB6
4160:TUBB4
4155:TUBB3
4135:TUBB1
4125:TUBA8
3474:Espin
3435:Other
3422:Titin
3228:Other
3217:MYLL1
3212:MYLK2
3202:MYLIP
3187:MYL6B
3120:MYO10
3110:MYO9B
3105:MYO9A
3095:MYO7B
3090:MYO7A
3070:MYO5C
3065:MYO5B
3060:MYO5A
3050:MYO3B
3045:MYO3A
3035:MYH16
3030:MYH15
3025:MYH14
3020:MYH13
3015:MYH11
3010:MYH10
2995:MYH7B
2954:MYO1H
2949:MYO1G
2944:MYO1F
2939:MYO1E
2934:MYO1D
2929:MYO1C
2924:MYO1B
2919:MYO1A
2834:Human
2725:(PDF)
2237:S2CID
2050:S2CID
1806:S2CID
1310:; in
1308:atria
1167:atria
1151:atria
1118:relax
1112:that
1103:atria
1068:liver
1052:aorta
1048:atria
1022:-14.
1004:VLC-2
960:atria
944:is a
679:17898
660:58498
639:Mouse
634:Human
605:Amigo
393:gonad
337:Mouse
330:Human
277:Start
212:Mouse
176:Start
109:Human
80:23290
5094:ParM
5089:MreB
5084:FtsZ
5044:ACF7
5037:PKP2
5032:PKP1
5015:TLN1
4930:SPTB
4908:ANK3
4903:ANK2
4898:ANK1
4807:DNM3
4802:DNM2
4797:DNM1
4701:PCM1
4351:KIF9
4346:KIF7
4341:KIF6
4268:MAP4
4263:MAP2
4230:MAPs
4130:TUBB
4073:MAPs
4071:and
4012:NEFH
4007:NEFM
4002:NEFL
3961:GFAP
3609:none
3467:FLNC
3462:FLNB
3457:FLNA
3207:MYLK
3197:MYL9
3192:MYL7
3182:MYL6
3177:MYL5
3172:MYL4
3167:MYL3
3162:MYL2
3157:MYL1
3086:VII
3080:MYO6
3041:III
3005:MYH9
3000:MYH8
2990:MYH7
2985:MYH6
2980:MYH4
2975:MYH3
2970:MYH2
2965:MYH1
2847:ABPs
2845:and
2780:PMID
2745:PMID
2709:PMID
2674:PMID
2639:PMID
2604:PMID
2558:PMID
2513:PMID
2464:PMID
2428:PMID
2379:PMID
2330:PMID
2278:PMID
2229:PMID
2188:PMID
2137:PMID
2086:PMID
2042:PMID
2006:PMID
1965:PMID
1924:PMID
1883:PMID
1847:PMID
1798:PMID
1763:PMID
1722:PMID
1687:PMID
1652:PMID
1610:2015
1581:PMID
1533:2015
1485:PMID
1365:MYH6
1240:and
1163:mRNA
1147:mRNA
1116:and
953:gene
950:MYL7
320:Bgee
268:Band
229:Chr.
172:7p13
167:Band
126:Chr.
88:MYL7
60:OMIM
47:MYL7
24:MYL7
4858:GAN
4841:APC
4248:EB3
4243:EB2
4238:EB1
4044:A/C
3727:33B
3722:33A
3126:XV
3101:IX
3076:VI
2961:II
2770:doi
2766:267
2737:doi
2733:295
2699:doi
2664:doi
2660:278
2629:doi
2594:doi
2548:doi
2503:PMC
2495:doi
2491:205
2456:doi
2418:PMC
2410:doi
2369:PMC
2361:doi
2320:hdl
2310:doi
2268:doi
2219:doi
2178:PMC
2168:doi
2127:PMC
2117:doi
2113:285
2078:doi
2074:165
2034:doi
1996:doi
1955:doi
1914:doi
1875:doi
1837:doi
1833:269
1790:doi
1753:doi
1749:254
1714:doi
1679:doi
1644:doi
1571:PMC
1563:doi
1559:114
1475:doi
1471:269
1340:in
1338:Asn
1336:820
1334:Ile
1224:in
1220:by
1184:at
1082:in
290:End
189:End
92:OMA
68:MGI
5125::
4054:B2
4049:B1
4042::
3918:80
3913:79
3908:78
3903:77
3898:76
3893:75
3888:74
3883:73
3878:72
3873:71
3857:40
3852:39
3847:28
3842:27
3837:26
3832:25
3827:24
3822:23
3797:86
3792:85
3787:84
3782:83
3777:82
3772:81
3752:38
3747:37
3742:36
3737:35
3732:34
3717:32
3712:31
3669:6C
3664:6B
3659:6A
3639:2A
3614:21
3602:18
3588:20
3583:19
3578:17
3573:16
3568:15
3563:14
3558:13
3553:12
3548:10
3152:LC
3116:X
3056:V
2915:I
2898:G2
2893:G1
2888:C1
2878:A2
2873:A1
2778:.
2764:.
2760:.
2743:.
2731:.
2727:.
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2695:58
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