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Unconventional myosin-Va

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and the dynamics of the SVs on the actin filaments. The absence of MYO5A in the brain can be associated with loco motor dysfunction and neuroendocrine abnormalities. As mention MYO5A is highly expressed on the neurons. Therefore, a mutation on MYO5A can be related with abnormal neuronal development
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In the presence of cargo adapters and calcium, unconventional myosin Va is present in an elongated and active state. It has an N-terminal head domain and a C-terminal tail domain. The actin-binding head (N-Terminal) is an ATP-dependent motor domain that transmits changes from the active site to the
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Assis, L. H. P.; Silva-Junior, R. M. P.; Dolce, L. G.; Alborghetti, M. R.; Honorato, R. V.; Nascimento, A. F. Z.; Melo-Hanchuk, T. D.; Trindade, D. M.; Tonoli, C. C. C.; Santos, C. T.; Oliveira, P. S. L.; Larson, R. E.; Kobarg, J.; Espreafico, E. M.; Giuseppe, P. O.; Murakami, M. T. (2017).
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Pastural E, Barrat FJ, Dufourcq-Lagelouse R, Certain S, Sanal O, Jabado N, Seger R, Griscelli C, Fischer A, de Saint Basile G (Jul 1997). "Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene".
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light chain lever arm. The C-terminal globular domain (GB) decides the Myosin class and moderate the cargo transport. Also, the GB interacts with other cargo specific proteins. Myosin Va is highly expressed in neurons and melanocytes.
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Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, Huang DC, Strasser A (Sep 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis".
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Pastural E, Ersoy F, Yalman N, Wulffraat N, Grillo E, Ozkinay F, Tezcan I, Gediköglu G, Philippe N, Fischer A, de Saint Basile G (Feb 2000). "Two genes are responsible for Griscelli syndrome at the same 15q21 locus".
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Schumacher-Bass, Sarah M.; Vesely, Eileen D.; Zhang, Lian; Ryland, Katherine E.; McEwen, Dyke P.; Chan, Priscilla J.; Frasier, Chad R.; McIntyre, Jeremy C.; Shaw, Robin M.; Martens, Jeffrey R. (2014-03-14).
2319:"The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation" 1458:
Myosin Va is highly expressed in the nervous system and it is present in almost the entire brain. MY5A perform an important role in the regulation of axonal vesicle transport on the
2995: 1486:) in the myocytes. Kv1.5 is associated with the regulation of the action potential in the myocytes. New strategies targeting Kv1.5 current through MYO5A and MYO5B in human 2630:"Molecular cloning and characterization of neural activity-related RING finger protein (NARF): a new member of the RBCC family is a candidate for the partner of myosin V" 2965: 342: 241: 2980: 1682:
Wöllert, Torsten; Patel, Anamika; Lee, Ying-Lung; Provance, D. William; Vought, Valarie E.; Cosgrove, Michael S.; Mercer, John A.; Langford, George M. (2011-04-22).
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in charge of the intracellular transport of vesicles, organelles and protein complexes along the actin filaments. In humans it is coded for by the
5381: 2945: 1585: 3694: 1567: 2665:"Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport" 2550:"Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein" 1932:"Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein" 3059: 328: 2809:
Anikster Y, Huizing M, Anderson PD, Fitzpatrick DL, Klar A, Gross-Kieselstein E, Berkun Y, Shazberg G, Gahl WA, Hurvitz H (Aug 2002).
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transport producing partial albinism. Griscelli syndrome type 1 can present with pigment defects and neurological disorders such as,
1327: 305: 1747:"A Role for Myosin V Motor Proteins in the Selective Delivery of Kv Channel Isoforms to the Membrane Surface of Cardiac Myocytes" 1447:
a rare autosomal recessive disorder. This defect is due a mutation in which a premature stop codon in the globular tail disrupt
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Mehta AD, Rock RS, Rief M, Spudich JA, Mooseker MS, Cheney RE (Aug 1999). "Myosin-V is a processive actin-based motor".
144: 3622: 1411: 341: 240: 5093: 334: 233: 2938: 1829:"Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene" 5326: 2442:"Inhibition of dendrite formation in mouse melanocytes transiently transfected with antisense DNA to myosin Va" 1133: 152: 2733:"A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport" 2811:"Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A" 1870:"Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types" 1114: 2515:"arg-cys substitution at codon 1246 of the human myosin Va gene is not associated with Griscelli syndrome" 2215:"Cloning and regional assignment of the human myosin heavy chain 12 (MYH12) gene to chromosome band 15q21" 3745: 3099: 216: 1462:. The GB of MYO5A can form a complex with Rab3A. The involvement of this complex is important for the 4014: 2931: 2865: 2404: 2143: 2087: 2041: 1881: 1621: 131: 5321: 3954: 1487: 1282: 1278: 1274: 1270: 1219: 1215: 1211: 1207: 2548:
Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, Weinberg RJ, Sheng M (Jun 2000).
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Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, Weinberg RJ, Sheng M (Jun 2000).
3774: 3404: 2428: 2362:"Cloning and characterization of a novel RING finger protein that interacts with class V myosins" 2272: 2111: 1610:"Structural Insights into the Globular Tails of the Human Type V Myosins Myo5a, Myo5b, and Myo5c" 1440: 176: 1303: 1266: 1240: 1203: 5172: 4875: 3536: 2903: 2883: 2840: 2797: 2754: 2719: 2686: 2651: 2616: 2581: 2536: 2501: 2471: 2420: 2383: 2348: 2305: 2264: 2234: 2103: 2059: 2010: 1961: 1909: 1850: 1784: 1766: 1723: 1705: 1657: 1639: 1472: 1444: 124: 56: 4895: 5120: 4827: 4812: 4807: 4802: 4797: 4787: 4708: 4417: 4397: 4367: 4362: 4244: 3599: 3594: 2873: 2830: 2822: 2787: 2779: 2744: 2711: 2676: 2641: 2606: 2571: 2561: 2526: 2513:
Lambert J, Naeyaert JM, De Paepe A, Van Coster R, Ferster A, Song M, Messiaen L (Apr 2000).
2493: 2461: 2453: 2412: 2373: 2338: 2330: 2297: 2256: 2226: 2159: 2151: 2095: 2049: 2000: 1992: 1951: 1943: 1899: 1889: 1840: 1774: 1758: 1713: 1695: 1647: 1629: 1467: 1463: 421: 352: 296: 251: 5037: 5032: 5027: 5022: 4777: 4767: 4757: 4752: 4723: 4427: 4422: 3469: 3357: 3347: 3322: 3302: 3206: 3186: 2854:"Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions" 2030:"Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions" 579: 172: 5262: 3876: 3726: 3609: 3429: 2285: 1482:
are involved with Kv1.5 (encoded by Potassium voltage-gated channel subfamily A member 5,
396: 3004:: CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITH ESSENTIAL LIGHT CHAIN + ADP-BEFX - NEAR RIGOR 2869: 2457: 2408: 2147: 2091: 2045: 1885: 1625: 5225: 5088: 3785: 3616: 3125: 2576: 2566: 2549: 2466: 2441: 2343: 2318: 2164: 2131: 1956: 1947: 1931: 1779: 1746: 1718: 1683: 1652: 1609: 39: 2878: 2853: 2835: 2810: 2792: 2767: 2054: 2029: 2005: 1980: 1003: 998: 993: 988: 983: 978: 973: 968: 963: 958: 953: 948: 943: 938: 933: 928: 923: 918: 913: 908: 903: 898: 893: 888: 883: 878: 873: 868: 863: 858: 853: 837: 832: 827: 822: 817: 812: 807: 802: 797: 792: 787: 782: 777: 772: 767: 762: 757: 752: 747: 742: 737: 732: 727: 722: 717: 712: 707: 702: 697: 692: 676: 671: 666: 661: 656: 651: 646: 641: 636: 631: 626: 621: 5375: 5289: 5284: 4249: 4119: 4068: 4018: 3958: 3880: 3848: 3789: 3575: 3094: 2912: 2646: 2629: 2531: 2514: 2432: 2132:"The molecular motor Myosin Va interacts with the cilia-centrosomal protein RPGRIP1L" 1904: 1869: 1459: 1383: 854:
regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
608: 2276: 1803:"MYO5A - Unconventional myosin-Va - Homo sapiens (Human) - MYO5A gene & protein" 5133: 4188: 3943: 3487: 3079: 2852:
Nagashima K, Torii S, Yi Z, Igarashi M, Okamoto K, Takeuchi T, Izumi T (Apr 2002).
2595:"The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif" 2286:"Human myosin V gene produces different transcripts in a cell type-specific manner" 2115: 2028:
Nagashima K, Torii S, Yi Z, Igarashi M, Okamoto K, Takeuchi T, Izumi T (Apr 2002).
414: 193: 156: 5105: 5083: 2974:: CRYSTAL STRUCTURE OF MYOSIN V MOTOR WITH ESSENTIAL LIGHT CHAIN - NUCLEOTIDE-FREE 1762: 2317:
Buss F, Kendrick-Jones J, Lionne C, Knight AE, Côté GP, Paul Luzio J (Dec 1998).
1684:"Myosin5a Tail Associates Directly with Rab3A-containing Compartments in Neurons" 1634: 180: 5279: 5230: 5100: 4990: 4320: 3764: 3719: 3638: 3560: 3108: 1590:
National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
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Proceedings of the National Academy of Sciences of the United States of America
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Ohkawa N, Kokura K, Matsu-Ura T, Obinata T, Konishi Y, Tamura TA (Jul 2001).
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Moore KJ, Testa JR, Francke U, Milatovich A, Copeland NG, Jenkins NA (1995).
1770: 1709: 1643: 5160: 5155: 5150: 5110: 4948: 4943: 4938: 4296: 4276: 3931: 3926: 3906: 3901: 3896: 3886: 3795: 3699: 3633: 2099: 1894: 1700: 1452: 1033: 557: 435: 380: 367: 279: 266: 168: 2887: 2844: 2801: 2783: 2758: 2749: 2732: 2723: 2690: 2681: 2664: 2655: 2620: 2611: 2594: 2585: 2540: 2505: 2497: 2475: 2424: 2387: 2334: 2301: 2107: 2063: 2014: 1996: 1965: 1845: 1828: 1788: 1727: 1661: 2715: 2352: 2309: 2268: 2238: 1913: 1854: 1367: 1362: 5274: 5235: 5167: 5140: 5007: 4995: 4870: 4865: 4306: 4301: 4223: 3657: 3652: 3514: 2700:"Human myosin-Vc is a novel class V myosin expressed in epithelial cells" 1802: 1351: 1178: 1159: 5301: 5255: 5145: 5075: 5044: 4974: 4969: 4933: 4928: 4923: 4890: 4860: 4855: 4850: 4845: 4530: 4462: 4457: 4452: 4447: 4442: 4334: 4271: 3759: 3704: 3645: 3628: 3589: 3075: 2917: 2907: 2768:"Rab27a is an essential component of melanosome receptor for myosin Va" 2260: 1981:"Rab27a is an essential component of melanosome receptor for myosin Va" 1145: 1100: 2284:
Lambert J, Naeyaert JM, Callens T, De Paepe A, Messiaen L (Nov 1998).
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Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC (Jul 2002).
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Bement WM, Hasson T, Wirth JA, Cheney RE, Mooseker MS (Jul 1994).
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establishment of endoplasmic reticulum localization to postsynapse
1018: 1014: 5346: 5341: 5336: 5296: 5267: 5182: 5059: 5054: 5049: 4953: 4603: 4598: 4593: 4520: 4515: 4382: 4264: 4259: 4254: 3714: 3709: 3667: 3580: 3570: 3565: 3459: 3449: 3444: 3434: 3424: 3419: 3414: 3409: 3332: 3257: 3252: 3242: 3237: 3232: 3227: 3222: 3217: 1390: 148: 3048: 2927: 588: 3034:: STRUCTURE OF APO-CALMODULIN BOUND TO UNCONVENTIONAL MYOSIN V 2923: 1004:
regulation of postsynaptic cytosolic calcium ion concentration
3019:: CRYSTAL STRUCTURE OF MYOSIN V MOTOR DOMAIN -NUCLEOTIDE-FREE 2902:
Overview of all the structural information available in the
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Lo KW, Naisbitt S, Fan JS, Sheng M, Zhang M (Apr 2001).
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Wu X, Wang F, Rao K, Sellers JR, Hammer JA (May 2002).
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Wu X, Wang F, Rao K, Sellers JR, Hammer JA (May 2002).
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Biochemical and Biophysical Research Communications
1296: 1259: 1233: 1196: 1546: 1544: 1542: 1525: 1523: 1521: 351: 250: 1455:, motor development delay and mental impairment. 1925: 1923: 1608:Velvarska, Hana; Niessing, Dierk (2013-12-10). 27:Protein-coding gene in the species Homo sapiens 1551:GRCm38: Ensembl release 89: ENSMUSG00000034593 3060: 2939: 2663:Fukuda M, Kuroda TS, Mikoshiba K (Apr 2002). 8: 1530:GRCh38: Ensembl release 89: ENSG00000197535 4330: 3770: 3752: 3113: 3104: 3090: 3067: 3053: 3045: 2946: 2932: 2924: 1029: 964:locomotion involved in locomotory behavior 914:long-chain fatty acid biosynthetic process 604: 392: 291: 188: 74: 2877: 2834: 2791: 2748: 2680: 2645: 2610: 2575: 2565: 2530: 2465: 2377: 2342: 2163: 2053: 2004: 1955: 1903: 1893: 1844: 1778: 1717: 1699: 1651: 1633: 1439:Defects in Myosin Va are associated with 2519:The Journal of Investigative Dermatology 2961: 2360:El-Husseini AE, Vincent SR (Jul 1999). 1517: 954:protein localization to plasma membrane 929:vesicle transport along actin filament 29: 2179: 2177: 2175: 924:cellular response to insulin stimulus 889:post-Golgi vesicle-mediated transport 356: 317: 312: 255: 214: 209: 7: 2698:Rodriguez OC, Cheney RE (Mar 2002). 1739: 1737: 1677: 1675: 1673: 1671: 1603: 1601: 1599: 135:, GS1, MYH12, MYO5, MYR12, myosin VA 2737:The Journal of Biological Chemistry 2669:The Journal of Biological Chemistry 2599:The Journal of Biological Chemistry 2458:10.1046/j.1469-7580.1999.19520173.x 2366:The Journal of Biological Chemistry 1688:The Journal of Biological Chemistry 2916:(Unconventional myosin-Va) at the 2815:American Journal of Human Genetics 2567:10.1523/JNEUROSCI.20-12-04524.2000 1948:10.1523/JNEUROSCI.20-12-04524.2000 1293: 1256: 1230: 1193: 1169: 1150: 1124: 1105: 1079: 1060: 899:endoplasmic reticulum localization 662:disordered domain specific binding 574: 492: 430: 409: 25: 2440:Edgar AJ, Bennett JP (Aug 1999). 1827:Engle LJ, Kennett RH (Feb 1994). 446:lateral nuclear group of thalamus 3695:Wiskott–Aldrich syndrome protein 3024: 3009: 2994: 2979: 2964: 2647:10.1046/j.1471-4159.2001.00373.x 2532:10.1046/j.1523-1747.2000.00933.x 909:regulation of Golgi organization 578: 340: 333: 327: 304: 239: 232: 226: 201: 38: 4916:Microtubule organising proteins 2219:Cytogenetics and Cell Genetics 984:chemical synaptic transmission 874:secretory granule localization 743:insulin-responsive compartment 589:More reference expression data 558:More reference expression data 1: 4963:Microtubule severing proteins 2879:10.1016/S0014-5793(02)02634-0 2772:Molecular Biology of the Cell 2055:10.1016/S0014-5793(02)02634-0 1985:Molecular Biology of the Cell 1763:10.1161/CIRCRESAHA.114.302711 884:actin filament-based movement 823:unconventional myosin complex 325: 224: 5382:Genes on human chromosome 15 3623:actin depolymerizing factors 1635:10.1371/journal.pone.0082065 859:melanin biosynthetic process 828:smooth endoplasmic reticulum 637:microfilament motor activity 5101:Plakoglobin (gamma catenin) 2554:The Journal of Neuroscience 2323:The Journal of Cell Biology 1936:The Journal of Neuroscience 748:photoreceptor outer segment 647:cytoskeletal motor activity 5403: 969:vesicle-mediated transport 959:melanocyte differentiation 939:developmental pigmentation 524:lateral geniculate nucleus 5357: 2959: 2634:Journal of Neurochemistry 1586:"Mouse PubMed Reference:" 1568:"Human PubMed Reference:" 1366: 1361: 1357: 1350: 1334: 1315: 1300: 1263: 1252: 1237: 1200: 1189: 1176: 1172: 1157: 1153: 1144: 1131: 1127: 1112: 1108: 1099: 1086: 1082: 1067: 1063: 1054: 1039: 1032: 1028: 1012: 904:melanin metabolic process 667:identical protein binding 607: 603: 586: 577: 568: 555: 508:medial geniculate nucleus 504: 495: 442: 433: 403: 395: 391: 374: 361: 324: 303: 294: 290: 273: 260: 223: 200: 191: 187: 142: 139: 129: 122: 117: 82: 77: 60: 55: 50: 46: 37: 32: 5327:Prokaryotic cytoskeleton 2379:10.1074/jbc.274.28.19771 1410:MYO5A has been shown to 1380:Unconventional myosin-Va 1321:Chr 15: 52.31 – 52.53 Mb 989:hair follicle maturation 536:dorsal tegmental nucleus 2704:Journal of Cell Science 2100:10.1126/science.1062257 1895:10.1073/pnas.91.14.6549 1701:10.1074/jbc.M110.187286 1490:(AF) are being studied. 1471:and the progression of 1328:Chr 9: 74.98 – 75.13 Mb 879:melanosome localization 2784:10.1091/mbc.01-12-0595 2750:10.1074/jbc.M202574200 2682:10.1074/jbc.C200005200 2612:10.1074/jbc.M010320200 2498:10.1006/geno.1999.6081 2335:10.1083/jcb.143.6.1535 2302:10.1006/bbrc.1998.9644 1997:10.1091/mbc.01-12-0595 1846:10.1006/geno.1994.1088 1443:type 1, also known as 677:actin filament binding 520:ventral tegmental area 478:superior frontal gyrus 5387:Genes mutated in mice 3947:(hard alpha-keratins) 3778:(soft alpha-keratins) 2716:10.1242/jcs.115.5.991 1466:(SVs) trafficking of 1434:Clinical significance 838:glutamatergic synapse 813:extracellular exosome 808:intermediate filament 783:endoplasmic reticulum 528:stroma of bone marrow 516:medial dorsal nucleus 217:Chromosome 15 (human) 5362:cytoskeletal defects 5322:Major sperm proteins 1751:Circulation Research 919:melanosome transport 864:synapse organization 763:microtubule plus-end 319:Chromosome 9 (mouse) 78:List of PDB id codes 51:Available structures 3775:Epithelial keratins 2870:2002FEBSL.517..233N 2409:1999Natur.400..590M 2189:www.clinicalkey.com 2148:2017NatSR...743692A 2092:2001Sci...293.1829P 2046:2002FEBSL.517..233N 1886:1994PNAS...91.6549B 1694:(16): 14352–14361. 1626:2013PLoSO...882065V 1488:atrial fibrillation 622:calcium ion binding 358:9 D|9 42.26 cM 2710:(Pt 5): 991–1004. 2446:Journal of Anatomy 2261:10.1038/ng0797-289 2136:Scientific Reports 1441:Griscelli syndrome 1134:ENSMUSG00000034593 847:Biological process 773:neuronal cell body 698:recycling endosome 686:Cellular component 632:calmodulin binding 627:nucleotide binding 615:Molecular function 5369: 5368: 5310: 5309: 5070: 5069: 4315: 4314: 4197: 4196: 3740: 3739: 3683: 3682: 3042: 3041: 2231:10.1159/000133937 2156:10.1038/srep43692 2086:(5536): 1829–32. 1473:neurodegeneration 1468:neurotransmitters 1464:synaptic vesicles 1445:Elejalde syndrome 1377: 1376: 1373: 1372: 1346: 1345: 1311: 1310: 1290: 1289: 1248: 1247: 1227: 1226: 1185: 1184: 1166: 1165: 1140: 1139: 1121: 1120: 1095: 1094: 1076: 1075: 1024: 1023: 974:visual perception 934:protein transport 869:insulin secretion 793:neuron projection 758:secretory granule 599: 598: 595: 594: 564: 563: 551: 550: 489: 488: 482:entorhinal cortex 470:postcentral gyrus 387: 386: 286: 285: 181:MYO5A - orthologs 113: 112: 109: 108: 61:Ortholog search: 16:(Redirected from 5394: 4331: 3771: 3753: 3114: 3105: 3091: 3069: 3062: 3055: 3046: 3028: 3013: 2998: 2983: 2968: 2948: 2941: 2934: 2925: 2891: 2881: 2848: 2838: 2805: 2795: 2762: 2752: 2743:(28): 25423–30. 2727: 2694: 2684: 2659: 2649: 2624: 2614: 2605:(17): 14059–66. 2589: 2579: 2569: 2544: 2534: 2509: 2479: 2469: 2436: 2391: 2381: 2356: 2346: 2313: 2280: 2242: 2199: 2198: 2196: 2195: 2181: 2170: 2169: 2167: 2126: 2120: 2119: 2074: 2068: 2067: 2057: 2025: 2019: 2018: 2008: 1976: 1970: 1969: 1959: 1927: 1918: 1917: 1907: 1897: 1865: 1859: 1858: 1848: 1824: 1818: 1817: 1815: 1813: 1799: 1793: 1792: 1782: 1741: 1732: 1731: 1721: 1703: 1679: 1666: 1665: 1655: 1637: 1605: 1594: 1593: 1582: 1576: 1575: 1564: 1558: 1548: 1537: 1527: 1426:, RPGRIP1L, and 1359: 1358: 1330: 1323: 1306: 1294: 1285: 1257: 1253:RefSeq (protein) 1243: 1231: 1222: 1194: 1170: 1151: 1125: 1106: 1080: 1061: 1030: 605: 591: 582: 575: 560: 500: 498:Top expressed in 493: 458:Brodmann area 23 450:endothelial cell 438: 436:Top expressed in 431: 410: 393: 383: 370: 359: 344: 337: 331: 320: 308: 292: 282: 269: 258: 243: 236: 230: 219: 205: 189: 183: 134: 127: 104: 75: 69: 48: 47: 42: 30: 21: 5402: 5401: 5397: 5396: 5395: 5393: 5392: 5391: 5372: 5371: 5370: 5365: 5353: 5306: 5209: 5115: 5066: 4979: 4958: 4910: 4733: 4525: 4477: 4323: 4311: 4281: 4228: 4193: 4177: 4061:Ungrouped alpha 4056: 3946: 3938: 3777: 3763: 3757: 3747: 3736: 3679: 3476: 3155: 3097: 3082: 3073: 3043: 3038: 3035: 3029: 3020: 3014: 3005: 2999: 2990: 2984: 2975: 2969: 2955: 2952: 2899: 2894: 2851: 2808: 2765: 2730: 2697: 2675:(14): 12432–6. 2662: 2627: 2592: 2560:(12): 4524–34. 2547: 2512: 2482: 2439: 2403:(6744): 590–3. 2394: 2372:(28): 19771–7. 2359: 2316: 2283: 2249:Nature Genetics 2245: 2212: 2208: 2206:Further reading 2203: 2202: 2193: 2191: 2183: 2182: 2173: 2128: 2127: 2123: 2076: 2075: 2071: 2027: 2026: 2022: 1978: 1977: 1973: 1942:(12): 4524–34. 1929: 1928: 1921: 1880:(14): 6549–53. 1867: 1866: 1862: 1826: 1825: 1821: 1811: 1809: 1807:www.uniprot.org 1801: 1800: 1796: 1743: 1742: 1735: 1681: 1680: 1669: 1607: 1606: 1597: 1584: 1583: 1579: 1566: 1565: 1561: 1549: 1540: 1528: 1519: 1514: 1497: 1436: 1408: 1399: 1368:View/Edit Mouse 1363:View/Edit Human 1326: 1319: 1316:Location (UCSC) 1302: 1281: 1277: 1273: 1269: 1265: 1239: 1218: 1214: 1210: 1206: 1202: 1115:ENSG00000197535 1008: 842: 718:Golgi apparatus 681: 672:protein binding 587: 556: 547: 544:globus pallidus 542: 538: 534: 530: 526: 522: 518: 514: 510: 496: 485: 480: 476: 472: 468: 464: 462:pars reticulata 460: 456: 452: 448: 434: 378: 365: 357: 347: 346: 345: 338: 318: 295:Gene location ( 277: 264: 256: 246: 245: 244: 237: 215: 192:Gene location ( 143: 130: 123: 84: 62: 28: 23: 22: 15: 12: 11: 5: 5400: 5398: 5390: 5389: 5384: 5374: 5373: 5367: 5366: 5358: 5355: 5354: 5352: 5351: 5350: 5349: 5344: 5339: 5334: 5324: 5318: 5316: 5312: 5311: 5308: 5307: 5305: 5304: 5299: 5294: 5293: 5292: 5287: 5277: 5272: 5271: 5270: 5260: 5259: 5258: 5253: 5248: 5243: 5238: 5233: 5228: 5226:Corneodesmosin 5217: 5215: 5211: 5210: 5208: 5207: 5206: 5205: 5200: 5195: 5190: 5185: 5180: 5175: 5165: 5164: 5163: 5158: 5153: 5143: 5138: 5137: 5136: 5125: 5123: 5117: 5116: 5114: 5113: 5108: 5103: 5098: 5097: 5096: 5086: 5080: 5078: 5072: 5071: 5068: 5067: 5065: 5064: 5063: 5062: 5057: 5052: 5042: 5041: 5040: 5035: 5030: 5025: 5020: 5010: 5005: 5004: 5003: 4993: 4987: 4985: 4981: 4980: 4978: 4977: 4972: 4966: 4964: 4960: 4959: 4957: 4956: 4951: 4946: 4941: 4936: 4931: 4926: 4920: 4918: 4912: 4911: 4909: 4908: 4903: 4898: 4893: 4888: 4883: 4878: 4873: 4868: 4863: 4858: 4853: 4848: 4841: 4840: 4835: 4830: 4825: 4820: 4815: 4810: 4805: 4800: 4795: 4790: 4785: 4780: 4775: 4770: 4765: 4760: 4755: 4750: 4743: 4741: 4735: 4734: 4732: 4731: 4726: 4721: 4716: 4711: 4706: 4701: 4696: 4691: 4686: 4681: 4676: 4671: 4666: 4661: 4656: 4651: 4646: 4641: 4636: 4631: 4626: 4621: 4616: 4611: 4606: 4601: 4596: 4591: 4586: 4581: 4576: 4571: 4566: 4561: 4556: 4551: 4546: 4541: 4535: 4533: 4527: 4526: 4524: 4523: 4518: 4513: 4508: 4503: 4498: 4493: 4487: 4485: 4479: 4478: 4476: 4475: 4470: 4465: 4460: 4455: 4450: 4445: 4440: 4435: 4430: 4425: 4420: 4415: 4410: 4405: 4400: 4395: 4390: 4385: 4380: 4375: 4370: 4365: 4360: 4355: 4350: 4345: 4339: 4337: 4328: 4317: 4316: 4313: 4312: 4310: 4309: 4304: 4299: 4293:Nuclear lamins 4289: 4287: 4283: 4282: 4280: 4279: 4274: 4269: 4268: 4267: 4262: 4257: 4247: 4242: 4236: 4234: 4230: 4229: 4227: 4226: 4221: 4216: 4211: 4205: 4203: 4199: 4198: 4195: 4194: 4192: 4191: 4185: 4183: 4179: 4178: 4176: 4175: 4174: 4173: 4168: 4163: 4158: 4153: 4148: 4143: 4138: 4133: 4128: 4115: 4114: 4113: 4112: 4107: 4102: 4097: 4092: 4087: 4082: 4077: 4064: 4062: 4058: 4057: 4055: 4054: 4053: 4052: 4047: 4042: 4037: 4032: 4027: 4010: 4009: 4008: 4007: 4002: 3997: 3992: 3987: 3982: 3977: 3972: 3967: 3950: 3948: 3940: 3939: 3937: 3936: 3935: 3934: 3929: 3924: 3919: 3914: 3909: 3904: 3899: 3894: 3889: 3872: 3871: 3870: 3869: 3859: 3858: 3857: 3845: 3844: 3843: 3838: 3833: 3828: 3823: 3818: 3813: 3808: 3803: 3798: 3781: 3779: 3768: 3750: 3742: 3741: 3738: 3737: 3735: 3734: 3729: 3724: 3723: 3722: 3717: 3712: 3702: 3697: 3691: 3689: 3685: 3684: 3681: 3680: 3678: 3677: 3672: 3671: 3670: 3665: 3655: 3650: 3649: 3648: 3643: 3642: 3641: 3636: 3619: 3617:Arp2/3 complex 3614: 3613: 3612: 3607: 3602: 3597: 3586: 3585: 3584: 3583: 3578: 3573: 3568: 3558: 3557: 3556: 3542: 3531: 3512: 3511: 3510: 3505: 3500: 3495: 3484: 3482: 3478: 3477: 3475: 3474: 3473: 3472: 3467: 3462: 3457: 3452: 3447: 3442: 3437: 3432: 3427: 3422: 3417: 3412: 3402: 3401: 3400: 3395: 3387: 3386: 3385: 3377: 3376: 3375: 3367: 3366: 3365: 3360: 3352: 3351: 3350: 3345: 3337: 3336: 3335: 3327: 3326: 3325: 3320: 3315: 3307: 3306: 3305: 3300: 3292: 3291: 3290: 3285: 3280: 3275: 3270: 3265: 3260: 3255: 3250: 3245: 3240: 3235: 3230: 3225: 3220: 3212: 3211: 3210: 3204: 3199: 3194: 3189: 3184: 3179: 3174: 3165: 3163: 3157: 3156: 3154: 3153: 3148: 3143: 3138: 3133: 3128: 3122: 3120: 3111: 3102: 3095:Microfilaments 3088: 3084: 3083: 3074: 3072: 3071: 3064: 3057: 3049: 3040: 3039: 3037: 3036: 3030: 3023: 3021: 3015: 3008: 3006: 3000: 2993: 2991: 2985: 2978: 2976: 2970: 2963: 2960: 2957: 2956: 2953: 2951: 2950: 2943: 2936: 2928: 2922: 2921: 2898: 2897:External links 2895: 2893: 2892: 2864:(1–3): 233–8. 2849: 2827:10.1086/341606 2806: 2778:(5): 1735–49. 2763: 2728: 2695: 2660: 2625: 2590: 2545: 2510: 2492:(3): 299–306. 2480: 2437: 2392: 2357: 2329:(6): 1535–45. 2314: 2281: 2243: 2209: 2207: 2204: 2201: 2200: 2171: 2121: 2069: 2040:(1–3): 233–8. 2020: 1991:(5): 1735–49. 1971: 1919: 1860: 1819: 1794: 1757:(6): 982–992. 1733: 1667: 1620:(12): e82065. 1595: 1577: 1559: 1538: 1516: 1515: 1513: 1510: 1509: 1508: 1503: 1496: 1493: 1492: 1491: 1476: 1460:neurofilaments 1456: 1435: 1432: 1407: 1404: 1398: 1395: 1375: 1374: 1371: 1370: 1365: 1355: 1354: 1348: 1347: 1344: 1343: 1341: 1339: 1332: 1331: 1324: 1317: 1313: 1312: 1309: 1308: 1298: 1297: 1291: 1288: 1287: 1261: 1260: 1254: 1250: 1249: 1246: 1245: 1235: 1234: 1228: 1225: 1224: 1198: 1197: 1191: 1187: 1186: 1183: 1182: 1174: 1173: 1167: 1164: 1163: 1155: 1154: 1148: 1142: 1141: 1138: 1137: 1129: 1128: 1122: 1119: 1118: 1110: 1109: 1103: 1097: 1096: 1093: 1092: 1084: 1083: 1077: 1074: 1073: 1065: 1064: 1058: 1052: 1051: 1046: 1041: 1037: 1036: 1026: 1025: 1022: 1021: 1010: 1009: 1007: 1006: 1001: 996: 991: 986: 981: 976: 971: 966: 961: 956: 951: 946: 941: 936: 931: 926: 921: 916: 911: 906: 901: 896: 891: 886: 881: 876: 871: 866: 861: 856: 850: 848: 844: 843: 841: 840: 835: 830: 825: 820: 818:myosin complex 815: 810: 805: 800: 795: 790: 788:actin filament 785: 780: 778:early endosome 775: 770: 768:filopodium tip 765: 760: 755: 750: 745: 740: 735: 730: 725: 720: 715: 710: 705: 700: 695: 689: 687: 683: 682: 680: 679: 674: 669: 664: 659: 654: 649: 644: 639: 634: 629: 624: 618: 616: 612: 611: 601: 600: 597: 596: 593: 592: 584: 583: 572: 566: 565: 562: 561: 553: 552: 549: 548: 546: 545: 541: 537: 533: 529: 525: 521: 517: 513: 512:pontine nuclei 509: 505: 502: 501: 490: 487: 486: 484: 483: 479: 475: 471: 467: 463: 459: 455: 451: 447: 443: 440: 439: 427: 426: 418: 407: 401: 400: 397:RNA expression 389: 388: 385: 384: 376: 372: 371: 363: 360: 355: 349: 348: 339: 332: 326: 322: 321: 316: 310: 309: 301: 300: 288: 287: 284: 283: 275: 271: 270: 262: 259: 254: 248: 247: 238: 231: 225: 221: 220: 213: 207: 206: 198: 197: 185: 184: 141: 137: 136: 128: 120: 119: 115: 114: 111: 110: 107: 106: 80: 79: 71: 70: 59: 53: 52: 44: 43: 35: 34: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 5399: 5388: 5385: 5383: 5380: 5379: 5377: 5364: 5363: 5356: 5348: 5345: 5343: 5340: 5338: 5335: 5333: 5330: 5329: 5328: 5325: 5323: 5320: 5319: 5317: 5313: 5303: 5300: 5298: 5295: 5291: 5288: 5286: 5283: 5282: 5281: 5278: 5276: 5273: 5269: 5266: 5265: 5264: 5261: 5257: 5254: 5252: 5249: 5247: 5244: 5242: 5239: 5237: 5234: 5232: 5229: 5227: 5224: 5223: 5222: 5219: 5218: 5216: 5212: 5204: 5201: 5199: 5196: 5194: 5191: 5189: 5186: 5184: 5181: 5179: 5176: 5174: 5171: 5170: 5169: 5166: 5162: 5159: 5157: 5154: 5152: 5149: 5148: 5147: 5144: 5142: 5139: 5135: 5132: 5131: 5130: 5127: 5126: 5124: 5122: 5118: 5112: 5109: 5107: 5106:Delta catenin 5104: 5102: 5099: 5095: 5092: 5091: 5090: 5087: 5085: 5084:Alpha catenin 5082: 5081: 5079: 5077: 5073: 5061: 5058: 5056: 5053: 5051: 5048: 5047: 5046: 5043: 5039: 5036: 5034: 5031: 5029: 5026: 5024: 5021: 5019: 5016: 5015: 5014: 5011: 5009: 5006: 5002: 4999: 4998: 4997: 4994: 4992: 4989: 4988: 4986: 4982: 4976: 4973: 4971: 4968: 4967: 4965: 4961: 4955: 4952: 4950: 4947: 4945: 4942: 4940: 4937: 4935: 4932: 4930: 4927: 4925: 4922: 4921: 4919: 4917: 4913: 4907: 4904: 4902: 4899: 4897: 4894: 4892: 4889: 4887: 4884: 4882: 4879: 4877: 4874: 4872: 4869: 4867: 4864: 4862: 4859: 4857: 4854: 4852: 4849: 4847: 4844:cytoplasmic: 4843: 4842: 4839: 4836: 4834: 4831: 4829: 4826: 4824: 4821: 4819: 4816: 4814: 4811: 4809: 4806: 4804: 4801: 4799: 4796: 4794: 4791: 4789: 4786: 4784: 4781: 4779: 4776: 4774: 4771: 4769: 4766: 4764: 4761: 4759: 4756: 4754: 4751: 4749: 4745: 4744: 4742: 4740: 4736: 4730: 4727: 4725: 4722: 4720: 4717: 4715: 4712: 4710: 4707: 4705: 4702: 4700: 4697: 4695: 4692: 4690: 4687: 4685: 4682: 4680: 4677: 4675: 4672: 4670: 4667: 4665: 4662: 4660: 4657: 4655: 4652: 4650: 4647: 4645: 4642: 4640: 4637: 4635: 4632: 4630: 4627: 4625: 4622: 4620: 4617: 4615: 4612: 4610: 4607: 4605: 4602: 4600: 4597: 4595: 4592: 4590: 4587: 4585: 4582: 4580: 4577: 4575: 4572: 4570: 4567: 4565: 4562: 4560: 4557: 4555: 4552: 4550: 4547: 4545: 4542: 4540: 4537: 4536: 4534: 4532: 4528: 4522: 4519: 4517: 4514: 4512: 4509: 4507: 4504: 4502: 4499: 4497: 4494: 4492: 4489: 4488: 4486: 4484: 4480: 4474: 4471: 4469: 4466: 4464: 4461: 4459: 4456: 4454: 4451: 4449: 4446: 4444: 4441: 4439: 4436: 4434: 4431: 4429: 4426: 4424: 4421: 4419: 4416: 4414: 4411: 4409: 4406: 4404: 4401: 4399: 4396: 4394: 4391: 4389: 4386: 4384: 4381: 4379: 4376: 4374: 4371: 4369: 4366: 4364: 4361: 4359: 4356: 4354: 4351: 4349: 4346: 4344: 4341: 4340: 4338: 4336: 4332: 4329: 4327: 4322: 4318: 4308: 4305: 4303: 4300: 4298: 4294: 4291: 4290: 4288: 4284: 4278: 4275: 4273: 4270: 4266: 4263: 4261: 4258: 4256: 4253: 4252: 4251: 4250:Neurofilament 4248: 4246: 4243: 4241: 4238: 4237: 4235: 4231: 4225: 4222: 4220: 4217: 4215: 4212: 4210: 4207: 4206: 4204: 4200: 4190: 4187: 4186: 4184: 4180: 4172: 4169: 4167: 4164: 4162: 4159: 4157: 4154: 4152: 4149: 4147: 4144: 4142: 4139: 4137: 4134: 4132: 4129: 4127: 4124: 4123: 4122: 4121: 4120:chromosome 12 4117: 4116: 4111: 4108: 4106: 4103: 4101: 4098: 4096: 4093: 4091: 4088: 4086: 4083: 4081: 4078: 4076: 4073: 4072: 4071: 4070: 4069:chromosome 17 4066: 4065: 4063: 4059: 4051: 4048: 4046: 4043: 4041: 4038: 4036: 4033: 4031: 4028: 4026: 4023: 4022: 4021: 4020: 4019:chromosome 12 4016: 4012: 4011: 4006: 4003: 4001: 3998: 3996: 3993: 3991: 3988: 3986: 3983: 3981: 3978: 3976: 3973: 3971: 3968: 3966: 3963: 3962: 3961: 3960: 3959:chromosome 17 3956: 3952: 3951: 3949: 3945: 3944:Hair keratins 3941: 3933: 3930: 3928: 3925: 3923: 3920: 3918: 3915: 3913: 3910: 3908: 3905: 3903: 3900: 3898: 3895: 3893: 3890: 3888: 3885: 3884: 3883: 3882: 3881:chromosome 12 3878: 3874: 3873: 3868: 3865: 3864: 3863: 3860: 3856: 3853: 3852: 3851: 3850: 3849:chromosome 12 3846: 3842: 3839: 3837: 3834: 3832: 3829: 3827: 3824: 3822: 3819: 3817: 3814: 3812: 3809: 3807: 3804: 3802: 3799: 3797: 3794: 3793: 3792: 3791: 3790:chromosome 17 3787: 3783: 3782: 3780: 3776: 3772: 3769: 3766: 3761: 3754: 3751: 3749: 3746:Intermediate 3743: 3733: 3730: 3728: 3725: 3721: 3718: 3716: 3713: 3711: 3708: 3707: 3706: 3703: 3701: 3698: 3696: 3693: 3692: 3690: 3686: 3676: 3673: 3669: 3666: 3664: 3661: 3660: 3659: 3656: 3654: 3651: 3647: 3644: 3640: 3637: 3635: 3632: 3631: 3630: 3627: 3626: 3625: 3624: 3620: 3618: 3615: 3611: 3608: 3606: 3603: 3601: 3598: 3596: 3593: 3592: 3591: 3588: 3587: 3582: 3579: 3577: 3574: 3572: 3569: 3567: 3564: 3563: 3562: 3559: 3555: 3552: 3549: 3546: 3543: 3541: 3538: 3535: 3532: 3530: 3527: 3524: 3521: 3518: 3517: 3516: 3513: 3509: 3506: 3504: 3501: 3499: 3496: 3494: 3491: 3490: 3489: 3486: 3485: 3483: 3479: 3471: 3468: 3466: 3463: 3461: 3458: 3456: 3453: 3451: 3448: 3446: 3443: 3441: 3438: 3436: 3433: 3431: 3428: 3426: 3423: 3421: 3418: 3416: 3413: 3411: 3408: 3407: 3406: 3403: 3399: 3396: 3394: 3391: 3390: 3388: 3384: 3381: 3380: 3378: 3374: 3371: 3370: 3368: 3364: 3361: 3359: 3356: 3355: 3353: 3349: 3346: 3344: 3341: 3340: 3338: 3334: 3331: 3330: 3328: 3324: 3321: 3319: 3316: 3314: 3311: 3310: 3308: 3304: 3301: 3299: 3296: 3295: 3293: 3289: 3286: 3284: 3281: 3279: 3276: 3274: 3271: 3269: 3266: 3264: 3261: 3259: 3256: 3254: 3251: 3249: 3246: 3244: 3241: 3239: 3236: 3234: 3231: 3229: 3226: 3224: 3221: 3219: 3216: 3215: 3213: 3208: 3205: 3203: 3200: 3198: 3195: 3193: 3190: 3188: 3185: 3183: 3180: 3178: 3175: 3173: 3170: 3169: 3167: 3166: 3164: 3162: 3158: 3152: 3149: 3147: 3144: 3142: 3139: 3137: 3134: 3132: 3129: 3127: 3124: 3123: 3121: 3119: 3115: 3112: 3110: 3106: 3103: 3101: 3096: 3092: 3089: 3085: 3081: 3077: 3070: 3065: 3063: 3058: 3056: 3051: 3050: 3047: 3033: 3027: 3022: 3018: 3012: 3007: 3003: 2997: 2992: 2988: 2982: 2977: 2973: 2967: 2962: 2958: 2949: 2944: 2942: 2937: 2935: 2930: 2929: 2926: 2919: 2915: 2914: 2909: 2905: 2901: 2900: 2896: 2889: 2885: 2880: 2875: 2871: 2867: 2863: 2859: 2855: 2850: 2846: 2842: 2837: 2832: 2828: 2824: 2821:(2): 407–14. 2820: 2816: 2812: 2807: 2803: 2799: 2794: 2789: 2785: 2781: 2777: 2773: 2769: 2764: 2760: 2756: 2751: 2746: 2742: 2738: 2734: 2729: 2725: 2721: 2717: 2713: 2709: 2705: 2701: 2696: 2692: 2688: 2683: 2678: 2674: 2670: 2666: 2661: 2657: 2653: 2648: 2643: 2639: 2635: 2631: 2626: 2622: 2618: 2613: 2608: 2604: 2600: 2596: 2591: 2587: 2583: 2578: 2573: 2568: 2563: 2559: 2555: 2551: 2546: 2542: 2538: 2533: 2528: 2524: 2520: 2516: 2511: 2507: 2503: 2499: 2495: 2491: 2487: 2481: 2477: 2473: 2468: 2463: 2459: 2455: 2452:(2): 173–84. 2451: 2447: 2443: 2438: 2434: 2430: 2426: 2422: 2418: 2417:10.1038/23072 2414: 2410: 2406: 2402: 2398: 2393: 2389: 2385: 2380: 2375: 2371: 2367: 2363: 2358: 2354: 2350: 2345: 2340: 2336: 2332: 2328: 2324: 2320: 2315: 2311: 2307: 2303: 2299: 2296:(2): 329–33. 2295: 2291: 2287: 2282: 2278: 2274: 2270: 2266: 2262: 2258: 2255:(3): 289–92. 2254: 2250: 2244: 2240: 2236: 2232: 2228: 2225:(1–2): 53–8. 2224: 2220: 2216: 2211: 2210: 2205: 2190: 2186: 2185:"ClinicalKey" 2180: 2178: 2176: 2172: 2166: 2161: 2157: 2153: 2149: 2145: 2141: 2137: 2133: 2125: 2122: 2117: 2113: 2109: 2105: 2101: 2097: 2093: 2089: 2085: 2081: 2073: 2070: 2065: 2061: 2056: 2051: 2047: 2043: 2039: 2035: 2031: 2024: 2021: 2016: 2012: 2007: 2002: 1998: 1994: 1990: 1986: 1982: 1975: 1972: 1967: 1963: 1958: 1953: 1949: 1945: 1941: 1937: 1933: 1926: 1924: 1920: 1915: 1911: 1906: 1901: 1896: 1891: 1887: 1883: 1879: 1875: 1871: 1864: 1861: 1856: 1852: 1847: 1842: 1839:(3): 407–16. 1838: 1834: 1830: 1823: 1820: 1808: 1804: 1798: 1795: 1790: 1786: 1781: 1776: 1772: 1768: 1764: 1760: 1756: 1752: 1748: 1740: 1738: 1734: 1729: 1725: 1720: 1715: 1711: 1707: 1702: 1697: 1693: 1689: 1685: 1678: 1676: 1674: 1672: 1668: 1663: 1659: 1654: 1649: 1645: 1641: 1636: 1631: 1627: 1623: 1619: 1615: 1611: 1604: 1602: 1600: 1596: 1591: 1587: 1581: 1578: 1573: 1569: 1563: 1560: 1556: 1552: 1547: 1545: 1543: 1539: 1535: 1531: 1526: 1524: 1522: 1518: 1511: 1507: 1504: 1502: 1499: 1498: 1494: 1489: 1485: 1481: 1477: 1474: 1469: 1465: 1461: 1457: 1454: 1450: 1446: 1442: 1438: 1437: 1433: 1431: 1429: 1425: 1421: 1417: 1413: 1405: 1403: 1396: 1394: 1392: 1389: 1385: 1384:motor protein 1381: 1369: 1364: 1360: 1356: 1353: 1349: 1342: 1340: 1337: 1333: 1329: 1325: 1322: 1318: 1314: 1307: 1305: 1299: 1295: 1292: 1286: 1284: 1280: 1276: 1272: 1268: 1262: 1258: 1255: 1251: 1244: 1242: 1236: 1232: 1229: 1223: 1221: 1217: 1213: 1209: 1205: 1199: 1195: 1192: 1190:RefSeq (mRNA) 1188: 1181: 1180: 1175: 1171: 1168: 1162: 1161: 1156: 1152: 1149: 1147: 1143: 1136: 1135: 1130: 1126: 1123: 1117: 1116: 1111: 1107: 1104: 1102: 1098: 1091: 1090: 1085: 1081: 1078: 1072: 1071: 1066: 1062: 1059: 1057: 1053: 1050: 1047: 1045: 1042: 1038: 1035: 1031: 1027: 1020: 1016: 1011: 1005: 1002: 1000: 997: 995: 992: 990: 987: 985: 982: 980: 977: 975: 972: 970: 967: 965: 962: 960: 957: 955: 952: 950: 947: 945: 942: 940: 937: 935: 932: 930: 927: 925: 922: 920: 917: 915: 912: 910: 907: 905: 902: 900: 897: 895: 894:odontogenesis 892: 890: 887: 885: 882: 880: 877: 875: 872: 870: 867: 865: 862: 860: 857: 855: 852: 851: 849: 846: 845: 839: 836: 834: 831: 829: 826: 824: 821: 819: 816: 814: 811: 809: 806: 804: 801: 799: 796: 794: 791: 789: 786: 784: 781: 779: 776: 774: 771: 769: 766: 764: 761: 759: 756: 754: 751: 749: 746: 744: 741: 739: 736: 734: 731: 729: 726: 724: 721: 719: 716: 714: 713:late endosome 711: 709: 706: 704: 701: 699: 696: 694: 691: 690: 688: 685: 684: 678: 675: 673: 670: 668: 665: 663: 660: 658: 655: 653: 650: 648: 645: 643: 642:actin binding 640: 638: 635: 633: 630: 628: 625: 623: 620: 619: 617: 614: 613: 610: 609:Gene ontology 606: 602: 590: 585: 581: 576: 573: 571: 567: 559: 554: 543: 539: 535: 531: 527: 523: 519: 515: 511: 507: 506: 503: 499: 494: 491: 481: 477: 473: 469: 466:parietal lobe 465: 461: 457: 454:Pars compacta 453: 449: 445: 444: 441: 437: 432: 429: 428: 425: 423: 419: 417: 416: 412: 411: 408: 406: 402: 398: 394: 390: 382: 377: 373: 369: 364: 354: 350: 343: 336: 330: 323: 315: 311: 307: 302: 298: 293: 289: 281: 276: 272: 268: 263: 253: 249: 242: 235: 229: 222: 218: 212: 208: 204: 199: 195: 190: 186: 182: 178: 174: 170: 166: 162: 158: 154: 150: 146: 138: 133: 126: 121: 116: 105: 103: 99: 95: 91: 87: 81: 76: 73: 72: 68: 65: 58: 54: 49: 45: 41: 36: 31: 19: 5359: 5134:Dystroglycan 5089:Beta catenin 4321:Microtubules 4189:Beta-keratin 4118: 4067: 4013: 3953: 3875: 3861: 3847: 3784: 3621: 3488:Tropomodulin 3080:cytoskeleton 3031: 3016: 3001: 2986: 2971: 2911: 2861: 2858:FEBS Letters 2857: 2818: 2814: 2775: 2771: 2740: 2736: 2707: 2703: 2672: 2668: 2640:(1): 75–87. 2637: 2633: 2602: 2598: 2557: 2553: 2525:(4): 731–3. 2522: 2518: 2489: 2485: 2449: 2445: 2400: 2396: 2369: 2365: 2326: 2322: 2293: 2289: 2252: 2248: 2222: 2218: 2192:. Retrieved 2188: 2139: 2135: 2124: 2083: 2079: 2072: 2037: 2034:FEBS Letters 2033: 2023: 1988: 1984: 1974: 1939: 1935: 1877: 1873: 1863: 1836: 1832: 1822: 1810:. Retrieved 1806: 1797: 1754: 1750: 1691: 1687: 1617: 1613: 1589: 1580: 1571: 1562: 1409: 1406:Interactions 1400: 1387: 1379: 1378: 1301: 1283:NP_001369278 1279:NP_001369277 1275:NP_001369276 1271:NP_001135967 1264: 1238: 1220:NM_001382349 1216:NM_001382348 1212:NM_001382347 1208:NM_001142495 1201: 1177: 1158: 1132: 1113: 1087: 1068: 1048: 1043: 949:pigmentation 420: 413: 140:External IDs 83: 5280:Plakophilin 5231:Desmoplakin 4991:Tau protein 3765:Cytokeratin 3561:Tropomyosin 3109:Myofilament 2954:PDB gallery 944:myelination 833:postsynapse 728:growth cone 657:RNA binding 652:ATP binding 379:75,130,970 366:74,978,297 278:52,529,132 265:52,307,281 118:Identifiers 5376:Categories 5360:See also: 5332:Crescentin 5251:Periplakin 5241:Envoplakin 5129:Dystrophin 4746:axonemal: 4240:Internexin 4219:Peripherin 2194:2019-12-04 1557:, May 2017 1536:, May 2017 1512:References 1478:MYO5A and 1449:melanosome 979:exocytosis 803:actomyosin 753:peroxisome 738:melanosome 424:(ortholog) 161:HomoloGene 4949:Centrin 3 4944:Centrin 2 4939:Centrin 1 4277:Syncoilin 4182:Not alpha 3748:filaments 3700:Fibrillin 2433:204995058 2142:: 43692. 1771:0009-7330 1710:0021-9258 1644:1932-6203 1453:hypotonia 1397:Structure 1304:NP_034994 1267:NP_000250 1241:NM_010864 1204:NM_000259 1034:Orthologs 994:transport 693:cytoplasm 532:subiculum 169:GeneCards 5315:Nonhuman 5275:Vinculin 5236:Dystonin 5168:Spectrin 5141:Utrophin 5121:Membrane 5076:Catenins 5008:Stathmin 4996:Dynactin 4876:DYNC2LI1 4871:DYNC1LI2 4866:DYNC1LI1 4531:Kinesins 4335:Tubulins 4224:Vimentin 3756:Type 1/2 3658:Profilin 3653:Gelsolin 3515:Troponin 3076:Proteins 2888:12062444 2845:12058346 2802:12006666 2759:11980908 2724:11870218 2691:11856727 2656:11432975 2621:11148209 2586:10844022 2541:10733681 2506:10704277 2486:Genomics 2476:10529054 2425:10448864 2388:10391919 2277:21815627 2108:11546872 2064:12062444 2015:12006666 1966:10844022 1833:Genomics 1812:11 April 1789:24508725 1728:21349835 1662:24339992 1614:PLOS ONE 1553:– 1532:– 1495:See also 1412:interact 1352:Wikidata 1013:Sources: 798:lysosome 723:membrane 540:habenula 5302:PLEKHA7 5256:Plectin 5221:Plakins 5146:Ankyrin 5045:Dynamin 4975:Spastin 4970:Katanin 4934:CAMSAP3 4929:CAMSAP2 4924:CAMSAP1 4896:DYNLRB2 4891:DYNLRB1 4861:DYNC1I2 4856:DYNC1I1 4851:DYNC2H1 4846:DYNC1H1 4739:Dyneins 4463:TUBGCP6 4458:TUBGCP5 4453:TUBGCP4 4448:TUBGCP3 4443:TUBGCP2 4272:Synemin 4015:type II 3877:type II 3760:Keratin 3705:Filamin 3646:Destrin 3629:Cofilin 3590:Actinin 3161:Myosins 3078:of the 2918:PDBe-KB 2908:UniProt 2866:Bibcode 2577:6772433 2467:1467982 2405:Bibcode 2353:9852149 2344:2132970 2310:9826529 2269:9207796 2239:7835087 2165:5339802 2144:Bibcode 2116:5638023 2088:Bibcode 2080:Science 2042:Bibcode 1957:6772433 1914:8022818 1882:Bibcode 1855:8188282 1780:4213814 1719:3077635 1653:3858360 1622:Bibcode 1555:Ensembl 1534:Ensembl 1146:UniProt 1101:Ensembl 1040:Species 1019:QuickGO 708:cytosol 703:vesicle 399:pattern 257:15q21.2 125:Aliases 5203:SPTBN5 5198:SPTBN4 5193:SPTBN2 5188:SPTBN1 5178:SPTAN1 5013:Tektin 4906:DYNLT3 4901:DYNLT1 4886:DYNLL2 4881:DYNLL1 4828:DNALI1 4813:DNAH17 4808:DNAH14 4803:DNAH13 4798:DNAH12 4793:DNAH11 4788:DNAH10 4709:KIF26B 4704:KIF26A 4679:KIF21B 4674:KIF21A 4669:KIF20B 4664:KIF20A 4654:KIF18B 4649:KIF18A 4639:KIF16B 4624:KIF13B 4619:KIF13A 4418:TUBB4Q 4403:TUBB2C 4398:TUBB2B 4393:TUBB2A 4373:TUBA4A 4368:TUBA3E 4363:TUBA3D 4358:TUBA3C 4353:TUBA1C 4348:TUBA1B 4343:TUBA1A 4286:Type 5 4245:Nestin 4233:Type 4 4209:Desmin 4202:Type 3 3955:type I 3786:type I 3732:TRIOBP 3398:MYO18B 3393:MYO18A 3389:XVIII 3383:MYO15A 3118:Actins 2913:Q9Y4I1 2886:  2843:  2836:379173 2833:  2800:  2793:111140 2790:  2757:  2722:  2689:  2654:  2619:  2584:  2574:  2539:  2504:  2474:  2464:  2431:  2423:  2397:Nature 2386:  2351:  2341:  2308:  2275:  2267:  2237:  2162:  2114:  2106:  2062:  2013:  2006:111140 2003:  1964:  1954:  1912:  1902:  1853:  1787:  1777:  1769:  1726:  1716:  1708:  1660:  1650:  1642:  1501:Myosin 1424:DYNLL2 1420:RAB27A 1416:DYNLL1 1338:search 1336:PubMed 1179:Q99104 1160:Q9Y4I1 1056:Entrez 733:ruffle 570:BioGPS 157:105976 149:160777 5263:Talin 5246:MACF1 5214:Other 5173:SPTA1 5038:TEKT5 5033:TEKT4 5028:TEKT3 5023:TEKT2 5018:TEKT1 5001:DCTN1 4984:Other 4838:DNAL4 4833:DNAL1 4823:DNAI2 4818:DNAI1 4783:DNAH9 4778:DNAH8 4773:DNAH7 4768:DNAH6 4763:DNAH5 4758:DNAH3 4753:DNAH2 4748:DNAH1 4729:KIFC3 4724:KIFC2 4719:KIFC1 4714:KIF27 4699:KIF25 4694:KIF24 4689:KIF23 4684:KIF22 4659:KIF19 4644:KIF17 4634:KIF15 4629:KIF14 4614:KIF12 4609:KIF11 4589:KIF5C 4584:KIF5B 4579:KIF5A 4574:KIF4B 4569:KIF4A 4564:KIF3C 4559:KIF3B 4554:KIF2C 4549:KIF2A 4544:KIF1B 4539:KIF1A 4511:MAP1B 4506:MAP1A 4473:TUBE1 4468:TUBD1 4438:TUBG2 4433:TUBG1 4428:TUBB8 4423:TUBB6 4413:TUBB4 4408:TUBB3 4388:TUBB1 4378:TUBA8 3727:Espin 3688:Other 3675:Titin 3481:Other 3470:MYLL1 3465:MYLK2 3455:MYLIP 3440:MYL6B 3373:MYO10 3363:MYO9B 3358:MYO9A 3348:MYO7B 3343:MYO7A 3323:MYO5C 3318:MYO5B 3313:MYO5A 3303:MYO3B 3298:MYO3A 3288:MYH16 3283:MYH15 3278:MYH14 3273:MYH13 3268:MYH11 3263:MYH10 3248:MYH7B 3207:MYO1H 3202:MYO1G 3197:MYO1F 3192:MYO1E 3187:MYO1D 3182:MYO1C 3177:MYO1B 3172:MYO1A 3087:Human 2429:S2CID 2273:S2CID 2112:S2CID 1905:44240 1506:MYP5B 1484:KCNA5 1480:MYO5B 1428:Rab3A 1414:with 1388:MYO5A 1382:is a 1089:17918 1049:Mouse 1044:Human 1015:Amigo 422:Mouse 415:Human 362:Start 297:Mouse 261:Start 194:Human 173:MYO5A 165:20100 132:MYO5A 33:MYO5A 18:MYO5A 5347:ParM 5342:MreB 5337:FtsZ 5297:ACF7 5290:PKP2 5285:PKP1 5268:TLN1 5183:SPTB 5161:ANK3 5156:ANK2 5151:ANK1 5060:DNM3 5055:DNM2 5050:DNM1 4954:PCM1 4604:KIF9 4599:KIF7 4594:KIF6 4521:MAP4 4516:MAP2 4483:MAPs 4383:TUBB 4326:MAPs 4324:and 4265:NEFH 4260:NEFM 4255:NEFL 4214:GFAP 3862:none 3720:FLNC 3715:FLNB 3710:FLNA 3460:MYLK 3450:MYL9 3445:MYL7 3435:MYL6 3430:MYL5 3425:MYL4 3420:MYL3 3415:MYL2 3410:MYL1 3339:VII 3333:MYO6 3294:III 3258:MYH9 3253:MYH8 3243:MYH7 3238:MYH6 3233:MYH4 3228:MYH3 3223:MYH2 3218:MYH1 3100:ABPs 3098:and 3032:2ix7 3017:1w8j 3002:1w7j 2987:1w7i 2972:1oe9 2906:for 2884:PMID 2841:PMID 2798:PMID 2755:PMID 2720:PMID 2687:PMID 2652:PMID 2617:PMID 2582:PMID 2537:PMID 2502:PMID 2472:PMID 2421:PMID 2384:PMID 2349:PMID 2306:PMID 2265:PMID 2235:PMID 2104:PMID 2060:PMID 2011:PMID 1962:PMID 1910:PMID 1851:PMID 1814:2022 1785:PMID 1767:ISSN 1724:PMID 1706:ISSN 1658:PMID 1640:ISSN 1391:gene 1070:4644 474:pons 405:Bgee 353:Band 314:Chr. 252:Band 211:Chr. 145:OMIM 102:4D07 98:4LLI 94:4LX2 90:4LX1 86:4J5L 67:RCSB 64:PDBe 5111:GAN 5094:APC 4501:EB3 4496:EB2 4491:EB1 4297:A/C 3980:33B 3975:33A 3379:XV 3354:IX 3329:VI 3214:II 2904:PDB 2874:doi 2862:517 2831:PMC 2823:doi 2788:PMC 2780:doi 2745:doi 2741:277 2712:doi 2708:115 2677:doi 2673:277 2642:doi 2607:doi 2603:276 2572:PMC 2562:doi 2527:doi 2523:114 2494:doi 2462:PMC 2454:doi 2450:195 2413:doi 2401:400 2374:doi 2370:274 2339:PMC 2331:doi 2327:143 2298:doi 2294:252 2257:doi 2227:doi 2160:PMC 2152:doi 2096:doi 2084:293 2050:doi 2038:517 2001:PMC 1993:doi 1952:PMC 1944:doi 1900:PMC 1890:doi 1841:doi 1775:PMC 1759:doi 1755:114 1714:PMC 1696:doi 1692:286 1648:PMC 1630:doi 375:End 274:End 177:OMA 153:MGI 57:PDB 5378:: 4307:B2 4302:B1 4295:: 4171:80 4166:79 4161:78 4156:77 4151:76 4146:75 4141:74 4136:73 4131:72 4126:71 4110:40 4105:39 4100:28 4095:27 4090:26 4085:25 4080:24 4075:23 4050:86 4045:85 4040:84 4035:83 4030:82 4025:81 4005:38 4000:37 3995:36 3990:35 3985:34 3970:32 3965:31 3922:6C 3917:6B 3912:6A 3892:2A 3867:21 3855:18 3841:20 3836:19 3831:17 3826:16 3821:15 3816:14 3811:13 3806:12 3801:10 3405:LC 3369:X 3309:V 3168:I 3151:G2 3146:G1 3141:C1 3131:A2 3126:A1 2910:: 2882:. 2872:. 2860:. 2856:. 2839:. 2829:. 2819:71 2817:. 2813:. 2796:. 2786:. 2776:13 2774:. 2770:. 2753:. 2739:. 2735:. 2718:. 2706:. 2702:. 2685:. 2671:. 2667:. 2650:. 2638:78 2636:. 2632:. 2615:. 2601:. 2597:. 2580:. 2570:. 2558:20 2556:. 2552:. 2535:. 2521:. 2517:. 2500:. 2490:63 2488:. 2470:. 2460:. 2448:. 2444:. 2427:. 2419:. 2411:. 2399:. 2382:. 2368:. 2364:. 2347:. 2337:. 2325:. 2321:. 2304:. 2292:. 2288:. 2271:. 2263:. 2253:16 2251:. 2233:. 2223:69 2221:. 2217:. 2187:. 2174:^ 2158:. 2150:. 2138:. 2134:. 2110:. 2102:. 2094:. 2082:. 2058:. 2048:. 2036:. 2032:. 2009:. 1999:. 1989:13 1987:. 1983:. 1960:. 1950:. 1940:20 1938:. 1934:. 1922:^ 1908:. 1898:. 1888:. 1878:91 1876:. 1872:. 1849:. 1837:19 1835:. 1831:. 1805:. 1783:. 1773:. 1765:. 1753:. 1749:. 1736:^ 1722:. 1712:. 1704:. 1690:. 1686:. 1670:^ 1656:. 1646:. 1638:. 1628:. 1616:. 1612:. 1598:^ 1588:. 1570:. 1541:^ 1520:^ 1430:. 1422:, 1418:, 1393:. 1017:/ 381:bp 368:bp 280:bp 267:bp 175:; 171:: 167:; 163:: 159:; 155:: 151:; 147:: 100:, 96:, 92:, 88:, 4017:/ 3957:/ 3932:8 3927:7 3907:5 3902:4 3897:3 3887:1 3879:/ 3796:9 3788:/ 3767:) 3762:, 3758:( 3668:2 3663:1 3639:2 3634:1 3610:4 3605:3 3600:2 3595:1 3581:4 3576:3 3571:2 3566:1 3554:3 3551:2 3548:1 3545:I 3540:2 3537:1 3534:C 3529:3 3526:2 3523:1 3520:T 3508:4 3503:3 3498:2 3493:1 3209:) 3136:B 3068:e 3061:t 3054:v 2947:e 2940:t 2933:v 2920:. 2890:. 2876:: 2868:: 2847:. 2825:: 2804:. 2782:: 2761:. 2747:: 2726:. 2714:: 2693:. 2679:: 2658:. 2644:: 2623:. 2609:: 2588:. 2564:: 2543:. 2529:: 2508:. 2496:: 2478:. 2456:: 2435:. 2415:: 2407:: 2390:. 2376:: 2355:. 2333:: 2312:. 2300:: 2279:. 2259:: 2241:. 2229:: 2197:. 2168:. 2154:: 2146:: 2140:7 2118:. 2098:: 2090:: 2066:. 2052:: 2044:: 2017:. 1995:: 1968:. 1946:: 1916:. 1892:: 1884:: 1857:. 1843:: 1816:. 1791:. 1761:: 1730:. 1698:: 1664:. 1632:: 1624:: 1618:8 1592:. 1574:. 1475:. 299:) 196:) 179:: 20:)

Index

MYO5A

PDB
PDBe
RCSB
4J5L
4LX1
4LX2
4LLI
4D07
Aliases
MYO5A
OMIM
160777
MGI
105976
HomoloGene
20100
GeneCards
MYO5A
OMA
MYO5A - orthologs
Human
Chromosome 15 (human)
Chr.
Chromosome 15 (human)
Chromosome 15 (human)
Genomic location for MYO5A
Genomic location for MYO5A
Band

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