25:
202:, and subsequently established Glycadia to develop therapeutic products. The company received initial financing from venture funds and the Commonwealth of Pennsylvania. Its first FDA-approved diagnostic product was Albuwell, a test that detects diabetic kidney disease, followed by other diagnostic products approved by the U.S.
1232:
Margo P. Cohen, Gregory T. Lautenslager et al. "Inhibiting albumin glycation attenuates dysregulation of VEGFR-1 and
Collagen IV subchain production and the development of renal insufficiency." Amer J Physiology – Renal Physiology 292:F789-F795,
178:
and
Metabolism at the Medical Center's Detroit Receiving Hospital. In 1982 she became Professor of Medicine and Head of the Division of Endocrinology and Metabolism at the University of Medicine and Dentistry of New Jersey. She received a
1364:
206:(FDA) to monitor diabetes management and complications. She holds twelve patents in the field of diabetes treatment. She continues to be the President and Chief Scientific Officer of Glycadia, .
1102:"Inhibiting low density lipoprotein glycation ameliorates increased cholesteryl synthesis in macrophages and hypercholesterolemia and aortic lipid peroxidation in streptozotocin diabetic rats"
1369:
998:
1149:
Kennedy, Laurence; Pilar Solano, Maria; Meneghini, Luigi; Lo, Margaret; Cohen, Margo P. (2010). "Anti-glycation and anti-albuminuric effects of GLY-230 in human diabetes".
131:
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1424:
224:
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158:. She was then awarded fellowships from the Public Health Service and the National Institutes of Health and pursued doctoral studies in biochemistry at
586:"Patent Application Titled "Long-Acting and Controlled Release Formulations of 2-[(3-Chlorophenyl) Amino] Phenylacetic Acid" Published Online"
171:
127:
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Cohen has contributed to several areas in endocrine and diabetes research. While in graduate school, she uncovered the mechanism by which the
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147:
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126:
is an
American physician and entrepreneur. She has been a Professor of Internal Medicine and Chief of Endocrinology and Metabolism at the
707:
Cash, Ralph; Brough, A. Joseph; Margo, N.P.Cohen; Satoh, Paul S. (1967). "Aminoglutethimide as an inhibitor of adrenal steroidogenesis".
483:
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284:. In Israel, Cohen discovered the increased prevalence of diabetes in young Ethiopian immigrants and linked it to radical changes in
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Cohen, M.P.; Grinblat, L. (1972). "Effect of diabetes on the activity of soluble factors required in ribosomal protein synthesis".
559:
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45:
1194:"Evidence linking glycated albumin to altered glomerular nephrin and VEGF expression, proteinuria, and diabetic nephropathy"
585:
216:
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503:
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37:
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Diabetes and
Protein Glycosylation: Methods of Measurement and Biologic Relevance; Springer Verlag, New York(1986)
315:
Cohen has authored and edited numerous books in the areas of diabetes, endocrinology and metabolism. These include:
81:
41:
1244:
1061:"Amelioration of Diabetes-Associated Abnormalities in the Vitreous Fluid by an Inhibitor of Albumin Glycation"
162:. Moving with her family to Argentina, she completed her doctoral program at the University of Buenos Aires.
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Endocrinology & Metabolism: Hormone
Resistance and Endocrine Paradoxes;Springer Verlag, New York (1987)
211:
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159:
143:
488:
437:
Diabetes and
Protein Glycation. Clinical and Pathophysiological Relevance;JC Press, Philadelphia(1996)
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134:. She is President and Chief Scientific Officer of Glycadia, and a founder of its subsidiary Exocell.
622:
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Cohen, Margo P.; Foglia, Virgilio G. (1970). "Aortic mucopolysaccharides in experimental diabetes".
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296:, eye and vascular complications tied to diabetes, uncovering the role of increased nonenzymatic
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1020:"Inhibiting albumin glycation in vivo ameliorates glomerular overexpression of TGF-bold beta1"
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in their genesis and identifying abnormalities in the production of matrix components and in
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Cohen, Margo P. (1968). "Aminoglutethimide inhibition of adrenal desmolase activity".
686:
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The Polyol
Paradigm and Complications of Diabetes; Springer Verlag, New York (1987)
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814:
771:
339:
Special Topics in
Endocrinology and Metabolism; Alan R. Liss, Inc., New York(1979)
611:
Richard Stone (May 21, 1993). "Dental
Institute Report Has NIH Down in the Mouth".
533:
293:
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657:"Translational Research | Vol 149, Issue 6, Pages A1-A8, 293-356 (June 2007)"
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219:. She was twice appointed Chairman of the Board of Scientific Counselors for the
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930:"High Prevalence of Diabetes in Young Adult Ethiopian Immigrants to Israel"
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Controversies in
Diabetes and Pregnancy; Springer Verlag, New York (1988)
280:. As a visiting scientist in England, she examined effects of diabetes on
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as Assistant Professor of Medicine, becoming Full Professor and head of
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at the National Institutes of Health. She was elected a member of the
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999:"Researchers closing in on a large scale test to screen for diabetes"
34:
may have been created or edited in return for undisclosed payments
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The Brain as an Endocrine Organ; Springer Verlag, New York(1989)
18:
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Diabetes and Autoimmunity; Springer Verlag, New York (1990)
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University of Medicine and Dentistry of New Jersey faculty
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Cohen married her college boyfriend, Perry M. Cohen, an
170:
Returning from Argentina, Cohen joined the faculty of
1100:
Cohen, Margo P.; Shea, Elizabeth; Wu, Van-Yu (2010).
1192:
Cohen, Margo P.; Chen, Sheldon; et al. (2005).
261:. In Argentina she studied the effects of diabetes,
40:. It may require cleanup to comply with Knowledge's
1249:. University of North Carolina Press. p. xii.
113:
103:
95:
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66:
1246:Healing at the Borderland of Medicine and Religion
873:"Nonenzymatic Glycosylation of Basement Membranes"
588:. Diabetes Week. February 17, 2014. Archived from
132:University of Medicine and Dentistry of New Jersey
1065:Investigative Ophthalmology & Visual Science
209:Cohen has been editor-in chief- of the Journal
150:. She held an internship at Sinai Hospital in
8:
1370:University of Michigan Medical School alumni
1018:Margo Cohen; et al. (October 8, 2001).
530:"Brotherly Love, Cheese Steaks And Biomed?"
225:American Society for Clinical Investigation
1059:Margo Cohen; et al. (November 2008).
183:in 1986 for a sabbatical in Israel at the
63:
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253:, leading to clinical use of the drug in
194:Cohen founded Exocell in 1988 to develop
172:Wayne State University School of Medicine
128:Wayne State University School of Medicine
457:, and she is the mother of three sons:.
465:
928:Margo Cohen; et al. (June 1988).
117:President and Chief Scientific Officer
1278:"Nancy Ann Jeffrey Weds Daniel Cohen"
871:Margo Cohen; et al. (May 1981).
482:Valerie Reitman (February 20, 1989).
477:
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221:National Institute of Dental Research
148:University of Michigan Medical School
78:University of Michigan Medical School
7:
215:and served on study sections of the
1425:American women business executives
979:Fetal nitrition and adult diabetes
246:interferes with the production of
14:
1375:University of Buenos Aires alumni
1211:10.1111/j.1523-1755.2005.00567.x
1037:10.1046/j.1523-1755.2002.00352.x
484:"A Doctor Gets Down To Business"
23:
16:American physician and scientist
1405:American women company founders
536:. March 3, 1991. Archived from
1420:American women medical writers
1360:Wayne State University faculty
997:Warren Leary (June 19, 1990).
1:
1118:10.1016/j.metabol.2009.09.010
217:National Institutes of Health
154:and a residency at Detroit's
36:, a violation of Knowledge's
1385:American medical researchers
687:"Margo Panush Cohen, MD PhD"
227:in 1982 and is currently an
204:Food and Drug Administration
1450:21st-century American women
142:Cohen earned a BS from the
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1445:American medical academics
756:10.3181/00379727-127-32877
560:"Margo P Cohen - Inventor"
292:diabetes and the cause of
288:. She has also researched
82:University of Buenos Aires
1440:American women scientists
1430:American women physicians
1400:American company founders
1390:American endocrinologists
1306:"Perry M. Cohen obituary"
1243:Michael H. Cohen (2007).
987:, Jul-Aug, 1994 pp. 53–54
1435:American women academics
1415:American medical writers
1410:Physicians from Michigan
1380:American diabetologists
709:J Clin Endocrinol Metab
635:10.1126/science.8493546
231:member of the society.
91:Physician, entrepreneur
1395:Women endocrinologists
842:10.1055/s-0028-1094060
721:10.1210/jcem-27-9-1239
189:University of Tel Aviv
160:Wayne State University
144:University of Michigan
949:10.2337/diab.37.6.824
892:10.2337/diab.30.5.367
799:10.2337/diab.19.9.639
744:Proc Soc Exp Biol Med
510:on September 13, 2017
489:Philadelphia Inquirer
181:Fulbright Scholarship
46:neutral point of view
1078:10.1167/iovs.08-1993
1024:Kidney International
566:on November 18, 2018
984:Scientific American
627:1993Sci...260.1069S
200:diagnostic products
156:Henry Ford Hospital
146:and an MD from the
302:signaling pathways
282:basement membranes
267:pituitary hormones
185:Beilinson Hospital
124:Margo Panush Cohen
1286:. August 18, 1991
1163:10.1159/000259897
540:on March 19, 2014
455:investment banker
271:protein synthesis
244:aminoglutethemide
152:Detroit, Michigan
121:
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108:Diabetes research
62:
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512:. Retrieved
508:the original
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38:terms of use
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257:-dependent
1349:Categories
1311:Legacy.com
1198:Kidney Int
1106:Metabolism
692:October 8,
672:2022-08-25
461:References
347:; (1980)
311:Publishing
305:inhibition
278:metabolism
1317:March 19,
596:March 19,
387:; (1985)
379:; (1984)
371:; (1983)
355:; (1981)
298:glycation
198:-related
138:Education
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1179:11014059
1171:19923796
1136:19922964
1087:18599566
1046:12028443
965:27276439
937:Diabetes
908:39313818
880:Diabetes
858:22160676
815:31726908
787:Diabetes
772:38942051
667:Elsevier
363:; (1982)
275:vascular
251:steroids
235:Research
229:emeritus
196:diabetes
130:and the
99:Glycadia
96:Employer
1127:2856719
957:3384182
900:7227657
850:5086196
807:4248450
764:4385282
729:4292247
643:8493546
623:Bibcode
614:Science
263:insulin
259:cancers
255:hormone
248:adrenal
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166:Career
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1264:2013
1251:ISBN
1233:2007
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