236:(Paxil, Seroxat) on adolescent depression. Keller's article concluded that paroxetine was "generally well tolerated and effective for major depression in adolescents." In fact, study 329 indicated otherwise for both efficacy and safety in treating teenagers, showing an increase in suicidality and emotional lability. The results were manipulated to downplay the significance of this finding. It was later found that the article had been
210:. He first identified the serious undertreatment of MDD in 1982, and later organized a consensus conference concluding that less than 10% of patients with MDD receive adequate treatment. He applied these findings and methodologies to empirically develop new short term and maintenance treatment strategies for bipolar disorder, recurrent MDD and chronic MDD; with medication and psychotherapy alone, and in combination.
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grants, his studies lead to a paradigm shift in understanding that mood and anxiety disorders are not short-lived episodes, but are primarily chronic, recurrent and disabling illnesses, expressed across the lifespan; which provided evidence to the
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Peter C. Gøtzsche (2015). Deadly
Psychiatry and Organised Denial. People's Press writes that he was receiving hundreds of thousands of dollars for research that was not disclosed and other facts.
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He has made contributions to standardized methods for assessing time to recovery, relapse, recurrence, and chronicity of episodes of
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Keller was listed as the lead author in 2001 of a controversial paper on study 329, a clinical trial funded by
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Keller discovered that about 25% of major depressive episodes were superimposed on
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report that depression is one of the more devastating public health problems.
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over time and has been used in over 1,000 research programs internationally.
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by
Scientific Therapeutics Information on behalf of the drug company.
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Journal of the
American Academy of Child and Adolescent Psychiatry
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Martin B. Keller, M.D. | Brain & Behavior
Research Foundation
23:. He is Professor Emeritus of Psychiatry and Human Behavior at
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354:. University of California, San Francisco. March 12, 2012
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320:Paul Thacker and Danielle Bryan (Nov 29, 2010).
322:"POGO Letter to NIH on Ghostwriting Academics"
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152:Keller earned his BA in psychology at
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262:, Brown Medical School.
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214:Efficacy of paroxetine
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