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Huggins was born in 1897 to Amos
Williamson Huggins and Mary Abigail Hackley. He had at least two sisters, Dorothea Harriet Huggins (born September 22, 1894) and Mary Abigail Huggins (born October 2, 1904). He earned his Ph.D. in 1922 under Charles Walter Porter (known as Walter Porter) in the
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and realized that the hydrogen bonding could not work as described since the bond geometry of the amide nitrogen (then presumed to be tetrahedral) would deflect the hydrogen away from the carbonyl oxygen. He further suggested that
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at the
Chemical Laboratory of the University of California, Berkeley. According to his account, he wrote a thesis in 1919 in which the H-bond was introduced and applied to
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might play a role in changing the geometry of the peptide bond to make the hydrogen bonds more linear. However, he did not state explicitly that the
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in 1920, who cite
Huggins' unpublished work in a footnote. (They were fellow scientists at the Chemical Laboratory.)
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Latimer WM and
Rodebush WH. (1920) "Polarity and Ionization from the Standpoint of the Lewis Theory of Valence",
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Chemistry
Laboratory of the University of California, Berkeley. In 1941 he was elected a Fellow of the
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Huggins also produced a model of the α-helix in 1943, roughly eight years ahead of the modern model of
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125:– December 17, 1981) was a scientist who independently conceived the idea of
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Huggins believed that he had been the first to suggest the concept of the
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was planar, as emphasized by
Pauling in a nearly simultaneous paper.
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and who was an early advocate for their role in stabilizing
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Huggins M. (1943) "The structure of fibrous proteins",
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Oral
History Interviews, American Institute of Physics
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464:Members of the Royal Swedish Academy of Sciences
184:In 1937, Huggins analyzed the β-sheet models of
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261:Calvin, Melvin; Seaborg, Glenn T. (1984).
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444:Fellows of the American Physical Society
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148:Controversies over the hydrogen bond
44:adding citations to reliable sources
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241:. He was employed as a chemist by
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119:Maurice Loyal Huggins
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221:Flory–Huggins theory
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412:Huggins ML. (1980)
401:Huggins ML. (1971)
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344:. January 11, 1976.
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