534:
511:
408:
433:
1347:
1445:, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. The symptoms of the disease typically start at infancy and may be additionally triggered by stress or bacterial infection. Children with mevalonate kinase deficiency may remain undiagnosed for a long time as there is not enough scientific data at the moment to accurately diagnose children with the disease.
540:
439:
4447:
29:
1411:
249:
1402:
is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. As the second enzyme in the
Mevalonate pathway, it catalyzes the phosphorylation of Mevalonic acid to produce Mevalonate-5-phosphate. A reduction in mevalonate kinase activity to around 5-10% of its
275:
1436:
Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause
3974:
2335:
Gattorno M, Sormani MP, D'Osualdo A, Pelagatti MA, Caroli F, Federici S, et al. (June 2008). "A diagnostic score for molecular analysis of hereditary autoinflammatory syndromes with periodic fever in children".
2597:
2173:
Nakayama K, Bayasgalan T, Yamanaka K, Kumada M, Gotoh T, Utsumi N, et al. (June 2009). "Large scale replication analysis of loci associated with lipid concentrations in a
Japanese population".
2072:
Marques-Vidal P, Bochud M, Paccaud F, Waterworth D, Bergmann S, Preisig M, et al. (August 2010). "No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels".
2259:"Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples"
3984:
2511:"Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study"
2590:
3979:
1378:
2136:
Samkari A, Borzutzky A, Fermo E, Treaba DO, Dedeoglu F, Altura RA (April 2010). "A novel missense mutation in MVK associated with MK deficiency and dyserythropoietic anemia".
1728:
Stabile A, Compagnone A, Napodano S, Raffaele CG, Patti M, Rigante D (December 2013). "Mevalonate kinase genotype in children with recurrent fevers and high serum IgD level".
2583:
1965:
Fu Z, Voynova NE, Herdendorf TJ, Miziorko HM, Kim JJ (March 2008). "Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism".
4099:
4077:
1791:
Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC (March 2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects".
547:
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203:
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222:
4005:
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2962:
1039:
1020:
4504:
3900:
369:
4067:
2793:
2739:
3157:
2907:
4523:
3706:
1598:
1580:
2676:
2575:
272:
3095:
3051:
2954:
2734:
1770:
1340:. Mevalonate kinases are found in a wide variety of organisms from bacteria to mammals. This enzyme catalyzes the following reaction:
1263:
533:
3840:
3043:
2979:
1438:
1270:
2466:"Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study"
4166:
3410:
3204:
2420:"Regulation of luteinizing hormone receptor mRNA expression by mevalonate kinase--role of the catalytic center in mRNA recognition"
1863:
Naruto T, Nakagishi Y, Mori M, Miyamae T, Imagawa T, Yokota S (2009). "Hyper-IgD syndrome with novel mutation in a
Japanese girl".
510:
1637:"Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria"
1403:
typical value is associated with the mevalonate kinase deficiency (MVD) resulting in accumulation of intermediate mevalonic acid.
3551:
1621:
215:
2851:
2681:
1567:
1546:
2832:
432:
407:
166:
142:
4322:
1563:
4497:
4124:
4119:
3679:
3497:
3167:
2874:
2822:
2755:
4437:
2103:"Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations"
1542:
3989:
3877:
3845:
3830:
2419:
337:
3512:
3162:
2716:
546:
445:
4307:
4423:
4410:
4397:
4384:
4371:
4358:
4345:
4110:
4088:
4063:
4038:
3958:
3566:
3526:
3471:
3448:
3420:
3388:
3254:
2827:
4317:
3341:
539:
438:
160:
4490:
4271:
4214:
3575:
3556:
3487:
3221:
2729:
2563:
1084:
357:
53:
147:
4533:
4219:
3433:
1442:
1065:
3887:
3660:
3570:
2798:
1350:
1363:
227:
4538:
4240:
4159:
3741:
3696:
3398:
3383:
3319:
3299:
3197:
2760:
1388:
1380:
421:
135:
38:
33:
4312:
3182:
2572:
provides an overview of all the structure information available in the PDB for Human
Mevalonate kinase
3655:
3650:
3530:
3393:
3373:
3282:
2932:
2813:
70:
324:
4276:
3918:
3910:
3691:
3358:
3294:
3258:
2803:
1994:
Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, et al. (January 2009).
1242:
1221:
1217:
1187:
1162:
1158:
163:
65:
1820:
Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, et al. (February 2008).
87:
4209:
3781:
3719:
3670:
3405:
3232:
3118:
2634:
2626:
2464:
Deo RC, Reich D, Tandon A, Akylbekova E, Patterson N, Waliszewska A, et al. (January 2009).
2452:
2198:
2161:
2101:
Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, et al. (December 2008).
1888:
1753:
1454:
1414:
381:
3004:
1635:
Schafer BL, Bishop RW, Kratunis VJ, Kalinowski SS, Mosley ST, Gibson KM, Tanaka RD (July 1992).
1246:
1213:
1183:
1154:
1822:"Newly identified loci that influence lipid concentrations and risk of coronary artery disease"
4528:
3796:
3786:
3776:
3701:
3685:
3644:
3630:
3625:
3326:
3129:
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2190:
2153:
2124:
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1982:
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1520:
1479:
317:
265:
154:
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4129:
3791:
3771:
3713:
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3492:
3438:
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3331:
3190:
3137:
2657:
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2434:
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2313:
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2270:
2254:
2231:
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2182:
2145:
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2081:
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2015:
2007:
1974:
1945:
1909:
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1800:
1737:
1697:
1689:
1648:
1510:
1502:
1346:
626:
557:
501:
456:
2300:
Simon A, van der Meer JW, Vesely R, Myrdal U, Yoshimura K, Duys P, Drenth JP (March 2006).
123:
4302:
4286:
4199:
4052:
4042:
3864:
3835:
3461:
3368:
3353:
2889:
2509:
Junyent M, Parnell LD, Lai CQ, Lee YC, Smith CE, Arnett DK, et al. (September 2009).
2085:
1804:
601:
377:
99:
2302:"Approach to genetic analysis in the diagnosis of hereditary autoinflammatory syndromes"
1930:
58:
4451:
4340:
4281:
4020:
3859:
3766:
3758:
3635:
3598:
2999:
2918:
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2535:
2510:
2492:
2465:
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2376:
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2020:
1995:
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842:
837:
832:
827:
822:
817:
178:
4517:
4245:
4204:
3289:
2569:
2439:
2377:"Allelic expression imbalance at high-density lipoprotein cholesterol locus MMAB-MVK"
804:
173:
2456:
2274:
2202:
2165:
1892:
4194:
3378:
3348:
3277:
2899:
1757:
619:
398:
361:
2318:
2301:
1410:
2482:
1489:
Oke M, Carter LG, Johnson KA, Liu H, McMahon SA, Yan X, et al. (June 2010).
385:
4418:
4353:
4189:
3944:
3934:
3535:
3272:
3213:
3015:
2927:
2842:
2775:
2686:
2668:
2618:
1900:
Krisans SK (October 1992). "The role of peroxisomes in cholesterol metabolism".
1603:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1585:
National Center for
Biotechnology Information, U.S. National Library of Medicine
182:
4446:
2119:
2102:
702:
28:
3746:
3589:
3502:
3267:
3217:
2785:
2606:
2257:, Riba L, Huertas-Vazquez A, Ordoñez-Sánchez ML, et al. (February 2010).
1876:
1741:
1693:
1506:
518:
415:
365:
1913:
4392:
4366:
4025:
3938:
3475:
3241:
3123:
3090:
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2186:
984:
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640:
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572:
484:
471:
373:
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2128:
2093:
2064:
2029:
1986:
1957:
1884:
1855:
1812:
1749:
1711:
1524:
1491:"The Scottish Structural Proteomics Facility: targets, methods and outputs"
1938:
Biochimica et
Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
1921:
1662:
1310:
1305:
248:
3872:
3452:
3082:
3025:
2940:
2652:
2392:
2358:
1931:"Biochemical and genetic aspects of mevalonate kinase and its deficiency"
1294:
1129:
1110:
2375:
Fogarty MP, Xiao R, Prokunina-Olsson L, Scott LJ, Mohlke KL (May 2010).
2055:
2038:
111:
3823:
3808:
3424:
3148:
3143:
3038:
3033:
2949:
2879:
2644:
2622:
1096:
1051:
130:
2349:
2210:
Koné-Paut I, Sanchez E, Le
Quellec A, Manna R, Touitou I (June 2007).
1978:
1483:
294:
4470:
4467:
4405:
4175:
3801:
3236:
3069:
3064:
2992:
2987:
2614:
1330:
1326:
1278:
1006:
210:
106:
94:
82:
2011:
4379:
3818:
3813:
3665:
1837:
1345:
3975:
CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
1996:"Common variants at 30 loci contribute to polygenic dyslipidemia"
969:
965:
3729:
3724:
3620:
3615:
3314:
3309:
3304:
1774:
1337:
945:
isopentenyl diphosphate biosynthetic process, mevalonate pathway
353:
349:
345:
341:
118:
4148:
3186:
2579:
1678:"Hyper-IgD syndrome/mevalonate kinase deficiency: what is new?"
4144:
1902:
American
Journal of Respiratory Cell and Molecular Biology
1367:
609:
4478:
4435:
3985:
CDP-diacylglycerol—inositol 3-phosphatidyltransferase
2212:"Autoinflammatory gene mutations in Behçet's disease"
1366:
774:
3990:
CDP-diacylglycerol—choline O-phosphatidyltransferase
3097:
3053:
3045:
2981:
2956:
1929:
Houten SM, Wanders RJ, Waterham HR (December 2000).
4331:
4295:
4264:
4233:
4182:
4109:
4087:
4062:
4037:
4018:
3998:
3980:
CDP-diacylglycerol—serine O-phosphatidyltransferase
3967:
3957:
3927:
3909:
3886:
3858:
3757:
3597:
3588:
3565:
3525:
3470:
3447:
3419:
3253:
3229:
3111:
3080:
3023:
3013:
2916:
2897:
2888:
2864:
2841:
2812:
2783:
2773:
2748:
2714:
2695:
2667:
2642:
2633:
2039:"Mevalonate kinase deficiency and autoinflammation"
1235:
1206:
1176:
1147:
221:
209:
197:
192:
172:
153:
141:
129:
117:
105:
93:
81:
76:
64:
52:
47:
21:
1559:
1557:
1555:
1538:
1536:
1534:
1372:
556:
455:
1723:
1721:
1564:GRCm38: Ensembl release 89: ENSMUSG00000041939
1431:hyperimmunoglobulinemia D with recurrent fever
950:regulation of cholesterol biosynthetic process
4498:
4160:
3198:
2591:
1495:Journal of Structural and Functional Genomics
8:
935:negative regulation of inflammatory response
4006:N-acetylglucosamine-1-phosphate transferase
3896:UTP—glucose-1-phosphate uridylyltransferase
1543:GRCh38: Ensembl release 89: ENSG00000110921
328:, LRBP, MK, MVLK, POROK3, mevalonate kinase
4505:
4491:
4167:
4153:
4145:
4034:
3964:
3594:
3585:
3250:
3205:
3191:
3183:
3020:
2894:
2780:
2639:
2598:
2584:
2576:
2515:The American Journal of Clinical Nutrition
980:
800:
597:
496:
393:
283:
189:
27:
4100:serine/threonine-specific protein kinases
4078:serine/threonine-specific protein kinases
3901:Galactose-1-phosphate uridylyltransferase
2562:at the U.S. National Library of Medicine
2534:
2491:
2481:
2438:
2418:Nair AK, Young MA, Menon KM (July 2008).
2400:
2357:
2317:
2282:
2235:
2118:
2054:
2019:
1845:
1701:
1676:Mulders-Manders CM, Simon A (July 2015).
1652:
1514:
1365:
2794:Farnesyl-diphosphate farnesyltransferase
2253:Weissglas-Volkov D, Aguilar-Salinas CA,
1616:
1614:
1612:
1409:
4442:
2740:Isopentenyl-diphosphate delta isomerase
1471:
16:Mammalian protein found in Homo sapiens
3158:Steroidogenic acute regulatory protein
238:
18:
2086:10.1016/j.atherosclerosis.2010.04.001
2037:Hager EJ, Gibson KM (November 2007).
1805:10.1016/j.atherosclerosis.2006.05.032
561:
522:
517:
460:
419:
414:
7:
4463:
4461:
2263:Circulation: Cardiovascular Genetics
2735:Pyrophosphomevalonate decarboxylase
2653:Acetyl-Coenzyme A acetyltransferase
2043:The New England Journal of Medicine
1771:Online Mendelian Inheritance in Man
1641:The Journal of Biological Chemistry
1373:{\displaystyle \rightleftharpoons }
1333:) that in humans is encoded by the
4477:. You can help Knowledge (XXG) by
1232:
1203:
1173:
1144:
1120:
1101:
1075:
1056:
1030:
1011:
779:
749:choroid plexus of fourth ventricle
697:
635:
614:
14:
3411:Glucose-1,6-bisphosphate synthase
4445:
3552:Ribose-phosphate diphosphokinase
2440:10.1111/j.1742-4658.2008.06490.x
2216:Annals of the Rheumatic Diseases
1622:"Entrez Gene: mevalonate kinase"
930:cholesterol biosynthetic process
545:
538:
532:
509:
444:
437:
431:
406:
247:
2908:Cholesterol side-chain cleavage
2852:24-Dehydrocholesterol reductase
2682:3-hydroxybutyrate dehydrogenase
2275:10.1161/CIRCGENETICS.109.908004
1429:Defects can be associated with
925:isoprenoid biosynthetic process
2833:7-Dehydrocholesterol reductase
763:More reference expression data
679:olfactory zone of nasal mucosa
1:
4125:Protein-histidine tele-kinase
4120:Protein-histidine pros-kinase
3999:Glycosyl-1-phosphotransferase
3168:Reverse cholesterol transport
2756:Dimethylallyltranstransferase
1950:10.1016/s1388-1981(00)00135-9
1654:10.1016/S0021-9258(18)42199-0
920:cholesterol metabolic process
530:
429:
4524:Genes on human chromosome 12
3831:RNA-dependent RNA polymerase
2483:10.1371/journal.pgen.1000342
940:steroid biosynthetic process
3738:RNA-directed DNA polymerase
3606:DNA-directed DNA polymerase
3163:Cholesterol total synthesis
2319:10.1093/rheumatology/kei138
2175:Journal of Medical Genetics
1682:Seminars in Immunopathology
905:sterol biosynthetic process
4555:
4460:
4091:: protein-dual-specificity
2875:Cholesterol 7α-hydroxylase
2823:Lanosterol 14α-demethylase
2120:10.1194/jlr.M800232-JLR200
1730:Rheumatology International
1439:hyperimmunoglobulinaemia D
838:mevalonate kinase activity
36:of mevalonate kinase from
34:Crystallographic structure
4323:Michaelis–Menten kinetics
2828:Sterol-C5-desaturase-like
2107:Journal of Lipid Research
1877:10.1007/s10165-008-0130-4
1742:10.1007/s00296-012-2577-z
1694:10.1007/s00281-015-0492-6
1599:"Mouse PubMed Reference:"
1581:"Human PubMed Reference:"
1507:10.1007/s10969-010-9090-y
1309:
1304:
1300:
1293:
1277:
1264:Chr 12: 109.57 – 109.6 Mb
1258:
1239:
1210:
1199:
1180:
1151:
1140:
1127:
1123:
1108:
1104:
1095:
1082:
1078:
1063:
1059:
1050:
1037:
1033:
1018:
1014:
1005:
990:
983:
979:
963:
900:steroid metabolic process
853:identical protein binding
803:
799:
787:
782:
773:
760:
709:
700:
647:
638:
608:
600:
596:
579:
566:
529:
508:
499:
495:
478:
465:
428:
405:
396:
392:
335:
332:
322:
315:
310:
291:
286:
269:
264:
259:
255:
246:
241:
188:
26:
4215:Diffusion-limited enzyme
4068:protein-serine/threonine
3968:Phosphatidyltransferases
3557:Thiamine diphosphokinase
2730:Phosphomevalonate kinase
2564:Medical Subject Headings
2381:Human Molecular Genetics
2338:Arthritis and Rheumatism
1271:Chr 5: 114.58 – 114.6 Mb
2527:10.3945/ajcn.2009.27738
2228:10.1136/ard.2006.068841
2187:10.1136/jmg.2008.064063
1443:periodic fever syndrome
4473:-related article is a
3888:Nucleotidyltransferase
3571:nucleotidyltransferase
3498:Nucleoside-diphosphate
2799:Squalene monooxygenase
2150:10.1542/peds.2009-1774
1914:10.1165/ajrcmb/7.4.358
1417:
1391:
1374:
659:pancreatic ductal cell
4308:Eadie–Hofstee diagram
4241:Allosteric regulation
3742:Reverse transcriptase
2880:Sterol 27-hydroxylase
2761:Geranyl pyrophosphate
1425:Clinical significance
1413:
1375:
1349:
843:magnesium ion binding
422:Chromosome 12 (human)
39:Staphylococcus aureus
4318:Lineweaver–Burk plot
3531:diphosphotransferase
3513:Thiamine-diphosphate
3220:-containing groups (
2814:7-Dehydrocholesterol
1364:
818:transferase activity
683:right adrenal cortex
524:Chromosome 5 (mouse)
287:List of PDB id codes
260:Available structures
4113:: protein-histidine
4031:; protein acceptor)
3919:mRNA capping enzyme
3911:Guanylyltransferase
2804:Lanosterol synthase
2056:10.1056/NEJMc072799
1865:Modern Rheumatology
687:left adrenal cortex
651:right lobe of liver
563:5 F|5 55.99 cM
4277:Enzyme superfamily
4210:Enzyme promiscuity
3389:Phosphoinositide 3
3233:phosphotransferase
3119:Steroid metabolism
2635:Mevalonate pathway
2627:steroid metabolism
2393:10.1093/hmg/ddq067
1455:Mevalonic aciduria
1418:
1415:Mevalonate pathway
1392:
1370:
1085:ENSMUSG00000041939
893:Biological process
867:Cellular component
823:nucleotide binding
811:Molecular function
725:Meckel's cartilage
4486:
4485:
4433:
4432:
4142:
4141:
4138:
4137:
4014:
4013:
3953:
3952:
3854:
3853:
3767:Template-directed
3521:
3520:
3488:Phosphomevalonate
3180:
3179:
3176:
3175:
3130:Steroid sulfatase
3107:
3106:
2860:
2859:
2769:
2768:
2725:Mevalonate kinase
2706:HMG-CoA reductase
2560:mevalonate+kinase
2350:10.1002/art.23474
1979:10.1021/bi7024386
1422:
1421:
1389:phosphomevalonate
1323:Mevalonate kinase
1320:
1319:
1316:
1315:
1289:
1288:
1254:
1253:
1229:
1228:
1195:
1194:
1170:
1169:
1136:
1135:
1117:
1116:
1091:
1090:
1072:
1071:
1046:
1045:
1027:
1026:
975:
974:
858:metal ion binding
795:
794:
791:
790:
769:
768:
756:
755:
745:entorhinal cortex
694:
693:
592:
591:
491:
490:
306:
305:
302:
301:
270:Ortholog search:
237:
236:
233:
232:
136:metabolic pathway
22:Mevalonate Kinase
4546:
4507:
4500:
4493:
4462:
4450:
4449:
4441:
4313:Hanes–Woolf plot
4256:Enzyme activator
4251:Enzyme inhibitor
4225:Enzyme catalysis
4169:
4162:
4155:
4146:
4130:Histidine kinase
4053:tyrosine kinases
4043:protein-tyrosine
4035:
3965:
3772:RNA polymerase I
3595:
3586:
3439:Aspartate kinase
3434:Phosphoglycerate
3251:
3207:
3200:
3193:
3184:
3138:sulfotransferase
3099:
3055:
3047:
3021:
2983:
2958:
2895:
2781:
2660:(regulated step)
2658:HMG-CoA synthase
2640:
2611:lipid metabolism
2600:
2593:
2586:
2577:
2548:
2538:
2505:
2495:
2485:
2460:
2442:
2433:(13): 3397–407.
2427:The FEBS Journal
2424:
2414:
2404:
2371:
2361:
2331:
2321:
2296:
2286:
2249:
2239:
2206:
2169:
2132:
2122:
2097:
2068:
2058:
2033:
2023:
1990:
1961:
1935:
1925:
1896:
1859:
1849:
1816:
1777:
1768:
1762:
1761:
1725:
1716:
1715:
1705:
1673:
1667:
1666:
1656:
1647:(19): 13229–38.
1632:
1626:
1625:
1618:
1607:
1606:
1595:
1589:
1588:
1577:
1571:
1561:
1550:
1540:
1529:
1528:
1518:
1486:
1476:
1406:
1405:
1379:
1377:
1376:
1371:
1329:(specifically a
1302:
1301:
1273:
1266:
1249:
1233:
1224:
1204:
1200:RefSeq (protein)
1190:
1174:
1165:
1145:
1121:
1102:
1076:
1057:
1031:
1012:
981:
915:lipid metabolism
801:
780:
765:
741:Ileal epithelium
733:ventricular zone
705:
703:Top expressed in
698:
643:
641:Top expressed in
636:
615:
598:
588:
575:
564:
549:
542:
536:
525:
513:
497:
487:
474:
463:
448:
441:
435:
424:
410:
394:
388:
327:
320:
297:
284:
278:
257:
256:
251:
239:
190:
31:
19:
4554:
4553:
4549:
4548:
4547:
4545:
4544:
4543:
4514:
4513:
4512:
4511:
4458:
4456:
4444:
4436:
4434:
4429:
4341:Oxidoreductases
4327:
4303:Enzyme kinetics
4291:
4287:List of enzymes
4260:
4229:
4200:Catalytic triad
4178:
4173:
4143:
4134:
4105:
4083:
4058:
4029:
4023:
4019:2.7.10-2.7.13:
4010:
3994:
3961:: miscellaneous
3949:
3923:
3905:
3882:
3865:exoribonuclease
3862:
3850:
3836:Polyadenylation
3753:
3579:
3573:
3561:
3543:
3539:
3533:
3517:
3479:
3466:
3443:
3415:
3245:
3239:
3231:
3225:
3211:
3181:
3172:
3112:Other/ungrouped
3103:
3076:
3034:17α-Hydroxylase
3009:
3005:11β-Hydroxylase
2950:17α-Hydroxylase
2919:corticosteroids
2912:
2890:Steroidogenesis
2884:
2856:
2837:
2808:
2765:
2744:
2710:
2691:
2663:
2629:
2604:
2556:
2551:
2508:
2476:(1): e1000342.
2463:
2422:
2417:
2374:
2334:
2299:
2252:
2209:
2172:
2135:
2100:
2074:Atherosclerosis
2071:
2036:
2000:Nature Genetics
1993:
1973:(12): 3715–24.
1964:
1933:
1928:
1899:
1862:
1826:Nature Genetics
1819:
1793:Atherosclerosis
1790:
1786:
1784:Further reading
1781:
1780:
1769:
1765:
1736:(12): 3039–42.
1727:
1726:
1719:
1675:
1674:
1670:
1634:
1633:
1629:
1620:
1619:
1610:
1597:
1596:
1592:
1579:
1578:
1574:
1562:
1553:
1541:
1532:
1488:
1478:
1477:
1473:
1468:
1451:
1427:
1397:
1362:
1361:
1311:View/Edit Mouse
1306:View/Edit Human
1269:
1262:
1259:Location (UCSC)
1245:
1241:
1220:
1216:
1212:
1186:
1182:
1161:
1157:
1153:
1066:ENSG00000110921
959:
910:phosphorylation
888:
862:
833:protein binding
828:kinase activity
761:
752:
747:
743:
739:
735:
731:
727:
723:
719:
715:
701:
690:
685:
681:
677:
673:
669:
667:skin of abdomen
665:
661:
657:
653:
639:
583:
570:
562:
552:
551:
550:
543:
523:
500:Gene location (
482:
469:
461:
451:
450:
449:
442:
420:
397:Gene location (
386:MVK - orthologs
336:
323:
316:
293:
271:
43:
17:
12:
11:
5:
4552:
4550:
4542:
4541:
4536:
4534:Human proteins
4531:
4526:
4516:
4515:
4510:
4509:
4502:
4495:
4487:
4484:
4483:
4455:
4454:
4431:
4430:
4428:
4427:
4414:
4401:
4388:
4375:
4362:
4349:
4335:
4333:
4329:
4328:
4326:
4325:
4320:
4315:
4310:
4305:
4299:
4297:
4293:
4292:
4290:
4289:
4284:
4279:
4274:
4268:
4266:
4265:Classification
4262:
4261:
4259:
4258:
4253:
4248:
4243:
4237:
4235:
4231:
4230:
4228:
4227:
4222:
4217:
4212:
4207:
4202:
4197:
4192:
4186:
4184:
4180:
4179:
4174:
4172:
4171:
4164:
4157:
4149:
4140:
4139:
4136:
4135:
4133:
4132:
4127:
4122:
4116:
4114:
4107:
4106:
4104:
4103:
4094:
4092:
4085:
4084:
4082:
4081:
4072:
4070:
4060:
4059:
4057:
4056:
4047:
4045:
4032:
4027:
4021:protein kinase
4016:
4015:
4012:
4011:
4009:
4008:
4002:
4000:
3996:
3995:
3993:
3992:
3987:
3982:
3977:
3971:
3969:
3962:
3955:
3954:
3951:
3950:
3948:
3947:
3942:
3931:
3929:
3925:
3924:
3922:
3921:
3915:
3913:
3907:
3906:
3904:
3903:
3898:
3892:
3890:
3884:
3883:
3881:
3880:
3875:
3869:
3867:
3860:Phosphorolytic
3856:
3855:
3852:
3851:
3849:
3848:
3843:
3838:
3833:
3828:
3827:
3826:
3821:
3816:
3806:
3805:
3804:
3794:
3789:
3784:
3779:
3774:
3769:
3763:
3761:
3759:RNA polymerase
3755:
3754:
3752:
3751:
3750:
3749:
3739:
3735:
3734:
3733:
3732:
3727:
3722:
3711:
3710:
3709:
3704:
3699:
3694:
3683:
3677:
3676:
3675:
3668:
3663:
3658:
3653:
3642:
3641:
3640:
3633:
3628:
3623:
3618:
3607:
3603:
3601:
3599:DNA polymerase
3592:
3583:
3577:
3563:
3562:
3560:
3559:
3554:
3548:
3546:
3541:
3537:
3523:
3522:
3519:
3518:
3516:
3515:
3510:
3505:
3500:
3495:
3490:
3484:
3482:
3477:
3468:
3467:
3465:
3464:
3458:
3456:
3445:
3444:
3442:
3441:
3436:
3430:
3428:
3417:
3416:
3414:
3413:
3408:
3403:
3402:
3401:
3396:
3386:
3384:Diacylglycerol
3381:
3376:
3371:
3366:
3361:
3356:
3351:
3346:
3345:
3344:
3334:
3329:
3324:
3323:
3322:
3317:
3312:
3307:
3302:
3295:Phosphofructo-
3292:
3287:
3286:
3285:
3275:
3270:
3264:
3262:
3248:
3243:
3227:
3226:
3212:
3210:
3209:
3202:
3195:
3187:
3178:
3177:
3174:
3173:
3171:
3170:
3165:
3160:
3154:
3153:
3152:
3151:
3146:
3134:
3133:
3132:
3115:
3113:
3109:
3108:
3105:
3104:
3102:
3101:
3093:
3087:
3085:
3078:
3077:
3075:
3074:
3073:
3072:
3067:
3057:
3049:
3041:
3036:
3030:
3028:
3018:
3011:
3010:
3008:
3007:
3002:
3000:21-Hydroxylase
2997:
2996:
2995:
2990:
2973:
2972:
2971:
2970:
2965:
2952:
2936:
2935:
2933:18-Hydroxylase
2923:
2921:
2914:
2913:
2911:
2910:
2904:
2902:
2892:
2886:
2885:
2883:
2882:
2877:
2871:
2869:
2862:
2861:
2858:
2857:
2855:
2854:
2848:
2846:
2839:
2838:
2836:
2835:
2830:
2825:
2819:
2817:
2810:
2809:
2807:
2806:
2801:
2796:
2790:
2788:
2778:
2771:
2770:
2767:
2766:
2764:
2763:
2758:
2752:
2750:
2746:
2745:
2743:
2742:
2737:
2732:
2727:
2721:
2719:
2712:
2711:
2709:
2708:
2702:
2700:
2698:Mevalonic acid
2693:
2692:
2690:
2689:
2684:
2679:
2673:
2671:
2665:
2664:
2662:
2661:
2655:
2649:
2647:
2637:
2631:
2630:
2605:
2603:
2602:
2595:
2588:
2580:
2574:
2573:
2567:
2555:
2554:External links
2552:
2550:
2549:
2506:
2461:
2415:
2387:(10): 1921–9.
2372:
2344:(6): 1823–32.
2332:
2297:
2250:
2207:
2170:
2133:
2113:(12): 2582–9.
2098:
2069:
2049:(18): 1871–2.
2034:
2012:10.1038/ng.291
1991:
1962:
1944:(1–3): 19–32.
1926:
1897:
1860:
1817:
1787:
1785:
1782:
1779:
1778:
1763:
1717:
1668:
1627:
1608:
1590:
1572:
1551:
1530:
1470:
1469:
1467:
1464:
1463:
1462:
1460:Mevalonic acid
1457:
1450:
1447:
1426:
1423:
1420:
1419:
1396:
1393:
1369:
1318:
1317:
1314:
1313:
1308:
1298:
1297:
1291:
1290:
1287:
1286:
1284:
1282:
1275:
1274:
1267:
1260:
1256:
1255:
1252:
1251:
1237:
1236:
1230:
1227:
1226:
1208:
1207:
1201:
1197:
1196:
1193:
1192:
1178:
1177:
1171:
1168:
1167:
1149:
1148:
1142:
1138:
1137:
1134:
1133:
1125:
1124:
1118:
1115:
1114:
1106:
1105:
1099:
1093:
1092:
1089:
1088:
1080:
1079:
1073:
1070:
1069:
1061:
1060:
1054:
1048:
1047:
1044:
1043:
1035:
1034:
1028:
1025:
1024:
1016:
1015:
1009:
1003:
1002:
997:
992:
988:
987:
977:
976:
973:
972:
961:
960:
958:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
902:
896:
894:
890:
889:
887:
886:
881:
876:
870:
868:
864:
863:
861:
860:
855:
850:
845:
840:
835:
830:
825:
820:
814:
812:
808:
807:
797:
796:
793:
792:
789:
788:
785:
784:
777:
771:
770:
767:
766:
758:
757:
754:
753:
751:
750:
746:
742:
738:
734:
730:
726:
722:
718:
714:
710:
707:
706:
695:
692:
691:
689:
688:
684:
680:
676:
672:
668:
664:
660:
656:
652:
648:
645:
644:
632:
631:
623:
612:
606:
605:
602:RNA expression
594:
593:
590:
589:
581:
577:
576:
568:
565:
560:
554:
553:
544:
537:
531:
527:
526:
521:
515:
514:
506:
505:
493:
492:
489:
488:
480:
476:
475:
467:
464:
459:
453:
452:
443:
436:
430:
426:
425:
418:
412:
411:
403:
402:
390:
389:
334:
330:
329:
321:
313:
312:
308:
307:
304:
303:
300:
299:
289:
288:
280:
279:
268:
262:
261:
253:
252:
244:
243:
235:
234:
231:
230:
225:
219:
218:
213:
207:
206:
201:
195:
194:
186:
185:
176:
170:
169:
158:
151:
150:
145:
139:
138:
133:
127:
126:
121:
115:
114:
109:
103:
102:
97:
91:
90:
85:
79:
78:
74:
73:
68:
62:
61:
56:
50:
49:
45:
44:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
4551:
4540:
4537:
4535:
4532:
4530:
4527:
4525:
4522:
4521:
4519:
4508:
4503:
4501:
4496:
4494:
4489:
4488:
4482:
4480:
4476:
4472:
4469:
4464:
4459:
4453:
4448:
4443:
4439:
4425:
4421:
4420:
4415:
4412:
4408:
4407:
4402:
4399:
4395:
4394:
4389:
4386:
4382:
4381:
4376:
4373:
4369:
4368:
4363:
4360:
4356:
4355:
4350:
4347:
4343:
4342:
4337:
4336:
4334:
4330:
4324:
4321:
4319:
4316:
4314:
4311:
4309:
4306:
4304:
4301:
4300:
4298:
4294:
4288:
4285:
4283:
4282:Enzyme family
4280:
4278:
4275:
4273:
4270:
4269:
4267:
4263:
4257:
4254:
4252:
4249:
4247:
4246:Cooperativity
4244:
4242:
4239:
4238:
4236:
4232:
4226:
4223:
4221:
4218:
4216:
4213:
4211:
4208:
4206:
4205:Oxyanion hole
4203:
4201:
4198:
4196:
4193:
4191:
4188:
4187:
4185:
4181:
4177:
4170:
4165:
4163:
4158:
4156:
4151:
4150:
4147:
4131:
4128:
4126:
4123:
4121:
4118:
4117:
4115:
4112:
4108:
4102:
4101:
4096:
4095:
4093:
4090:
4086:
4080:
4079:
4074:
4073:
4071:
4069:
4065:
4061:
4055:
4054:
4049:
4048:
4046:
4044:
4040:
4036:
4033:
4030:
4022:
4017:
4007:
4004:
4003:
4001:
3997:
3991:
3988:
3986:
3983:
3981:
3978:
3976:
3973:
3972:
3970:
3966:
3963:
3960:
3956:
3946:
3943:
3940:
3936:
3933:
3932:
3930:
3926:
3920:
3917:
3916:
3914:
3912:
3908:
3902:
3899:
3897:
3894:
3893:
3891:
3889:
3885:
3879:
3876:
3874:
3871:
3870:
3868:
3866:
3861:
3857:
3847:
3844:
3842:
3839:
3837:
3834:
3832:
3829:
3825:
3822:
3820:
3817:
3815:
3812:
3811:
3810:
3807:
3803:
3800:
3799:
3798:
3795:
3793:
3790:
3788:
3785:
3783:
3780:
3778:
3775:
3773:
3770:
3768:
3765:
3764:
3762:
3760:
3756:
3748:
3745:
3744:
3743:
3740:
3737:
3736:
3731:
3728:
3726:
3723:
3721:
3718:
3717:
3715:
3712:
3708:
3705:
3703:
3700:
3698:
3695:
3693:
3690:
3689:
3687:
3684:
3681:
3678:
3674:
3673:
3669:
3667:
3664:
3662:
3659:
3657:
3654:
3652:
3649:
3648:
3646:
3643:
3639:
3638:
3634:
3632:
3629:
3627:
3624:
3622:
3619:
3617:
3614:
3613:
3611:
3608:
3605:
3604:
3602:
3600:
3596:
3593:
3591:
3587:
3584:
3581:
3572:
3568:
3564:
3558:
3555:
3553:
3550:
3549:
3547:
3544:
3532:
3528:
3524:
3514:
3511:
3509:
3506:
3504:
3501:
3499:
3496:
3494:
3491:
3489:
3486:
3485:
3483:
3480:
3473:
3469:
3463:
3460:
3459:
3457:
3454:
3450:
3446:
3440:
3437:
3435:
3432:
3431:
3429:
3426:
3422:
3418:
3412:
3409:
3407:
3404:
3400:
3399:Class II PI 3
3397:
3395:
3392:
3391:
3390:
3387:
3385:
3382:
3380:
3377:
3375:
3374:Deoxycytidine
3372:
3370:
3367:
3365:
3362:
3360:
3357:
3355:
3352:
3350:
3347:
3343:
3342:ADP-thymidine
3340:
3339:
3338:
3335:
3333:
3330:
3328:
3325:
3321:
3318:
3316:
3313:
3311:
3308:
3306:
3303:
3301:
3298:
3297:
3296:
3293:
3291:
3288:
3284:
3281:
3280:
3279:
3276:
3274:
3271:
3269:
3266:
3265:
3263:
3260:
3256:
3252:
3249:
3246:
3238:
3234:
3228:
3223:
3219:
3215:
3208:
3203:
3201:
3196:
3194:
3189:
3188:
3185:
3169:
3166:
3164:
3161:
3159:
3156:
3155:
3150:
3147:
3145:
3142:
3141:
3140:
3139:
3135:
3131:
3128:
3127:
3126:
3125:
3120:
3117:
3116:
3114:
3110:
3100:
3094:
3092:
3089:
3088:
3086:
3084:
3079:
3071:
3068:
3066:
3063:
3062:
3061:
3058:
3056:
3050:
3048:
3042:
3040:
3037:
3035:
3032:
3031:
3029:
3027:
3022:
3019:
3017:
3012:
3006:
3003:
3001:
2998:
2994:
2991:
2989:
2986:
2985:
2984:
2978:
2975:
2974:
2969:
2966:
2964:
2961:
2960:
2959:
2953:
2951:
2948:
2946:
2942:
2938:
2937:
2934:
2931:
2929:
2925:
2924:
2922:
2920:
2915:
2909:
2906:
2905:
2903:
2901:
2896:
2893:
2891:
2887:
2881:
2878:
2876:
2873:
2872:
2870:
2868:
2863:
2853:
2850:
2849:
2847:
2844:
2840:
2834:
2831:
2829:
2826:
2824:
2821:
2820:
2818:
2815:
2811:
2805:
2802:
2800:
2797:
2795:
2792:
2791:
2789:
2787:
2782:
2779:
2777:
2772:
2762:
2759:
2757:
2754:
2753:
2751:
2747:
2741:
2738:
2736:
2733:
2731:
2728:
2726:
2723:
2722:
2720:
2718:
2713:
2707:
2704:
2703:
2701:
2699:
2694:
2688:
2685:
2683:
2680:
2678:
2677:HMG-CoA lyase
2675:
2674:
2672:
2670:
2666:
2659:
2656:
2654:
2651:
2650:
2648:
2646:
2641:
2638:
2636:
2632:
2628:
2624:
2620:
2616:
2612:
2608:
2601:
2596:
2594:
2589:
2587:
2582:
2581:
2578:
2571:
2568:
2565:
2561:
2558:
2557:
2553:
2546:
2542:
2537:
2532:
2528:
2524:
2521:(3): 686–94.
2520:
2516:
2512:
2507:
2503:
2499:
2494:
2489:
2484:
2479:
2475:
2471:
2470:PLOS Genetics
2467:
2462:
2458:
2454:
2450:
2446:
2441:
2436:
2432:
2428:
2421:
2416:
2412:
2408:
2403:
2398:
2394:
2390:
2386:
2382:
2378:
2373:
2369:
2365:
2360:
2359:11368/2299050
2355:
2351:
2347:
2343:
2339:
2333:
2329:
2325:
2320:
2315:
2312:(3): 269–73.
2311:
2307:
2303:
2298:
2294:
2290:
2285:
2280:
2276:
2272:
2268:
2264:
2260:
2256:
2255:Sinsheimer JS
2251:
2247:
2243:
2238:
2233:
2229:
2225:
2221:
2217:
2213:
2208:
2204:
2200:
2196:
2192:
2188:
2184:
2180:
2176:
2171:
2167:
2163:
2159:
2155:
2151:
2147:
2144:(4): e964-8.
2143:
2139:
2134:
2130:
2126:
2121:
2116:
2112:
2108:
2104:
2099:
2095:
2091:
2087:
2083:
2079:
2075:
2070:
2066:
2062:
2057:
2052:
2048:
2044:
2040:
2035:
2031:
2027:
2022:
2017:
2013:
2009:
2005:
2001:
1997:
1992:
1988:
1984:
1980:
1976:
1972:
1968:
1963:
1959:
1955:
1951:
1947:
1943:
1939:
1932:
1927:
1923:
1919:
1915:
1911:
1908:(4): 358–64.
1907:
1903:
1898:
1894:
1890:
1886:
1882:
1878:
1874:
1870:
1866:
1861:
1857:
1853:
1848:
1843:
1839:
1838:10.1038/ng.76
1835:
1831:
1827:
1823:
1818:
1814:
1810:
1806:
1802:
1798:
1794:
1789:
1788:
1783:
1776:
1772:
1767:
1764:
1759:
1755:
1751:
1747:
1743:
1739:
1735:
1731:
1724:
1722:
1718:
1713:
1709:
1704:
1699:
1695:
1691:
1687:
1683:
1679:
1672:
1669:
1664:
1660:
1655:
1650:
1646:
1642:
1638:
1631:
1628:
1623:
1617:
1615:
1613:
1609:
1604:
1600:
1594:
1591:
1586:
1582:
1576:
1573:
1569:
1565:
1560:
1558:
1556:
1552:
1548:
1544:
1539:
1537:
1535:
1531:
1526:
1522:
1517:
1512:
1508:
1504:
1501:(2): 167–80.
1500:
1496:
1492:
1485:
1481:
1475:
1472:
1465:
1461:
1458:
1456:
1453:
1452:
1448:
1446:
1444:
1440:
1434:
1432:
1424:
1416:
1412:
1408:
1407:
1404:
1401:
1394:
1390:
1386:
1382:
1360:
1356:
1352:
1348:
1344:
1341:
1339:
1336:
1332:
1328:
1324:
1312:
1307:
1303:
1299:
1296:
1292:
1285:
1283:
1280:
1276:
1272:
1268:
1265:
1261:
1257:
1250:
1248:
1244:
1238:
1234:
1231:
1225:
1223:
1219:
1215:
1209:
1205:
1202:
1198:
1191:
1189:
1185:
1179:
1175:
1172:
1166:
1164:
1160:
1156:
1150:
1146:
1143:
1141:RefSeq (mRNA)
1139:
1132:
1131:
1126:
1122:
1119:
1113:
1112:
1107:
1103:
1100:
1098:
1094:
1087:
1086:
1081:
1077:
1074:
1068:
1067:
1062:
1058:
1055:
1053:
1049:
1042:
1041:
1036:
1032:
1029:
1023:
1022:
1017:
1013:
1010:
1008:
1004:
1001:
998:
996:
993:
989:
986:
982:
978:
971:
967:
962:
956:
953:
951:
948:
946:
943:
941:
938:
936:
933:
931:
928:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
897:
895:
892:
891:
885:
882:
880:
877:
875:
872:
871:
869:
866:
865:
859:
856:
854:
851:
849:
846:
844:
841:
839:
836:
834:
831:
829:
826:
824:
821:
819:
816:
815:
813:
810:
809:
806:
805:Gene ontology
802:
798:
786:
781:
778:
776:
772:
764:
759:
748:
744:
740:
736:
732:
728:
724:
720:
716:
712:
711:
708:
704:
699:
696:
686:
682:
678:
674:
670:
666:
662:
658:
654:
650:
649:
646:
642:
637:
634:
633:
630:
628:
624:
622:
621:
617:
616:
613:
611:
607:
603:
599:
595:
587:
582:
578:
574:
569:
559:
555:
548:
541:
535:
528:
520:
516:
512:
507:
503:
498:
494:
486:
481:
477:
473:
468:
458:
454:
447:
440:
434:
427:
423:
417:
413:
409:
404:
400:
395:
391:
387:
383:
379:
375:
371:
367:
363:
359:
355:
351:
347:
343:
339:
331:
326:
319:
314:
309:
298:
296:
290:
285:
282:
281:
277:
274:
267:
263:
258:
254:
250:
245:
240:
229:
226:
224:
220:
217:
214:
212:
208:
205:
202:
200:
196:
191:
187:
184:
180:
177:
175:
174:Gene Ontology
171:
168:
165:
162:
159:
156:
152:
149:
146:
144:
140:
137:
134:
132:
128:
125:
122:
120:
116:
113:
112:NiceZyme view
110:
108:
104:
101:
98:
96:
92:
89:
86:
84:
80:
75:
72:
69:
67:
63:
60:
57:
55:
51:
46:
41:
40:
35:
30:
25:
20:
4539:EC 2.7 stubs
4479:expanding it
4465:
4457:
4419:Translocases
4416:
4403:
4390:
4377:
4364:
4354:Transferases
4351:
4338:
4195:Binding site
4097:
4075:
4050:
3671:
3636:
3394:Class I PI 3
3363:
3359:Pantothenate
3230:2.7.1-2.7.4:
3214:Transferases
3136:
3122:
3060:5α-Reductase
3016:sex hormones
2976:
2939:
2926:
2900:pregnenolone
2724:
2518:
2514:
2473:
2469:
2430:
2426:
2384:
2380:
2341:
2337:
2309:
2306:Rheumatology
2305:
2266:
2262:
2222:(6): 832–4.
2219:
2215:
2181:(6): 370–4.
2178:
2174:
2141:
2137:
2110:
2106:
2080:(2): 551–7.
2077:
2073:
2046:
2042:
2006:(1): 56–65.
2003:
1999:
1970:
1967:Biochemistry
1966:
1941:
1937:
1905:
1901:
1868:
1864:
1832:(2): 161–9.
1829:
1825:
1799:(1): 63–72.
1796:
1792:
1766:
1733:
1729:
1688:(4): 371–6.
1685:
1681:
1671:
1644:
1640:
1630:
1602:
1593:
1584:
1575:
1498:
1494:
1474:
1435:
1428:
1398:
1384:
1354:
1342:
1334:
1322:
1321:
1243:NP_001293134
1240:
1222:NP_001288111
1218:NP_001107657
1211:
1188:NM_001306205
1181:
1163:NM_001301182
1159:NM_001114185
1152:
1128:
1109:
1083:
1064:
1038:
1019:
999:
994:
675:right testis
625:
618:
584:114,598,652
571:114,582,330
483:109,598,125
470:109,573,255
333:External IDs
292:
100:BRENDA entry
37:
4190:Active site
3945:Transposase
3935:Recombinase
3580:-nucleoside
3406:Sphingosine
3039:17,20-Lyase
2928:aldosterone
2843:Desmosterol
2776:cholesterol
2687:Thiophorase
2669:Ketogenesis
2619:cholesterol
2269:(1): 31–8.
1871:(1): 96–9.
848:ATP binding
729:neural tube
671:left testis
663:skin of leg
311:Identifiers
88:IntEnz view
48:Identifiers
4518:Categories
4393:Isomerases
4367:Hydrolases
4234:Regulation
3747:Telomerase
3590:Polymerase
3364:Mevalonate
3327:Riboflavin
3218:phosphorus
2867:Bile acids
2786:lanosterol
2621:synthesis
2607:Metabolism
2138:Pediatrics
1570:, May 2017
1549:, May 2017
1466:References
1400:Mevalonate
1359:mevalonate
955:metabolism
884:peroxisome
655:C1 segment
629:(ortholog)
366:HomoloGene
157:structures
124:KEGG entry
71:9026-52-2
4272:EC number
3939:Integrase
3863:3' to 5'
3508:Guanylate
3503:Uridylate
3493:Adenylate
3337:Thymidine
3332:Shikimate
3124:sulfatase
3091:Aromatase
3083:estrogens
3026:androgens
2945:cortisone
1487:;
1368:⇌
1247:NP_076045
1214:NP_000422
1184:NM_023556
1155:NM_000431
985:Orthologs
874:cytoplasm
737:esophagus
374:GeneCards
77:Databases
4529:EC 2.7.1
4296:Kinetics
4220:Cofactor
4183:Activity
3873:RNase PH
3481:acceptor
3462:Creatine
3455:acceptor
3427:acceptor
3369:Pyruvate
3354:Glycerol
3315:Platelet
3290:Galacto-
3261:acceptor
2941:cortisol
2749:Geranyl-
2545:19605566
2502:19148283
2457:25641224
2449:18494797
2411:20159775
2368:18512793
2328:16234278
2293:20160193
2246:17213252
2203:35374041
2195:19487539
2166:24915125
2158:20194276
2129:18660489
2094:20430392
2065:17978300
2030:19060906
1987:18302342
1958:11111075
1893:25331505
1885:18941711
1856:18193043
1813:16806233
1773:(OMIM):
1750:23239036
1712:25990874
1566:–
1545:–
1525:20419351
1449:See also
1395:Function
1295:Wikidata
964:Sources:
721:yolk sac
462:12q24.11
228:proteins
216:articles
204:articles
161:RCSB PDB
59:2.7.1.36
4452:Biology
4406:Ligases
4176:Enzymes
3824:PrimPol
3809:Primase
3283:Hepatic
3278:Fructo-
3149:SULT2A1
3144:SULT1A1
2645:HMG-CoA
2623:enzymes
2615:ketones
2570:PDBe-KB
2536:2728650
2493:2613537
2402:2860891
2284:2827864
2237:1954666
2021:2881676
1922:1356376
1847:5206900
1758:3220012
1703:4491100
1663:1377680
1568:Ensembl
1547:Ensembl
1516:2883930
1097:UniProt
1052:Ensembl
991:Species
970:QuickGO
879:cytosol
604:pattern
318:Aliases
183:QuickGO
148:profile
131:MetaCyc
66:CAS no.
4471:enzyme
4468:EC 2.7
4438:Portal
4380:Lyases
4111:2.7.13
4089:2.7.12
4064:2.7.11
4039:2.7.10
3878:PNPase
3846:PNPase
3802:POLRMT
3797:ssRNAP
3310:Muscle
3273:Gluco-
3237:kinase
2566:(MeSH)
2543:
2533:
2500:
2490:
2455:
2447:
2409:
2399:
2366:
2326:
2291:
2281:
2244:
2234:
2201:
2193:
2164:
2156:
2127:
2092:
2063:
2028:
2018:
1985:
1956:
1920:
1891:
1883:
1854:
1844:
1811:
1775:260920
1756:
1748:
1710:
1700:
1661:
1523:
1513:
1331:kinase
1327:enzyme
1325:is an
1281:search
1279:PubMed
1130:Q9R008
1111:Q03426
1007:Entrez
775:BioGPS
717:tongue
362:107624
354:175900
350:610377
346:260920
342:251170
211:PubMed
193:Search
179:AmiGO
167:PDBsum
107:ExPASy
95:BRENDA
83:IntEnz
54:EC no.
4466:This
4332:Types
3959:2.7.8
3928:Other
3567:2.7.7
3527:2.7.6
3472:2.7.4
3449:2.7.3
3421:2.7.2
3305:Liver
3268:Hexo-
3255:2.7.1
2977:both:
2717:DMAPP
2453:S2CID
2423:(PDF)
2199:S2CID
2162:S2CID
1934:(PDF)
1889:S2CID
1754:S2CID
1040:17855
1000:Mouse
995:Human
966:Amigo
627:Mouse
620:Human
567:Start
502:Mouse
466:Start
399:Human
143:PRIAM
4475:stub
4424:list
4417:EC7
4411:list
4404:EC6
4398:list
4391:EC5
4385:list
4378:EC4
4372:list
4365:EC3
4359:list
4352:EC2
4346:list
4339:EC1
4098:see
4076:see
4051:see
3425:COOH
3224:2.7)
3096:17β-
3052:17β-
2955:11β-
2845:path
2816:path
2541:PMID
2498:PMID
2445:PMID
2407:PMID
2364:PMID
2324:PMID
2289:PMID
2242:PMID
2191:PMID
2154:PMID
2125:PMID
2090:PMID
2061:PMID
2026:PMID
1983:PMID
1954:PMID
1942:1529
1918:PMID
1881:PMID
1852:PMID
1809:PMID
1746:PMID
1708:PMID
1659:PMID
1521:PMID
1484:2X7I
1441:and
1338:gene
1021:4598
610:Bgee
558:Band
519:Chr.
457:Band
416:Chr.
338:OMIM
295:2R3V
276:RCSB
273:PDBe
223:NCBI
164:PDBe
119:KEGG
3841:PAP
3782:III
3716:/Y
3707:TDT
3688:/X
3680:III
3672:Pfu
3647:/B
3637:Taq
3612:/A
3379:PFP
3349:NAD
3098:HSD
3081:To
3054:HSD
3046:HSD
3044:3β-
3024:To
3014:To
2982:HSD
2980:3β-
2957:HSD
2917:To
2898:To
2865:To
2784:To
2774:To
2715:To
2696:To
2643:To
2531:PMC
2523:doi
2488:PMC
2478:doi
2435:doi
2431:275
2397:PMC
2389:doi
2354:hdl
2346:doi
2314:doi
2279:PMC
2271:doi
2232:PMC
2224:doi
2183:doi
2146:doi
2142:125
2115:doi
2082:doi
2078:211
2051:doi
2047:357
2016:PMC
2008:doi
1975:doi
1946:doi
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