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deliver fresh tumour samples into a foggy London. The flight was diverted to
Manchester causing a delay in delivery. When the samples finally arrived into London, they seemed useless, containing a cloudy fluid. However, under the microscope the cloudiness was not due to bacteria, as originally thought, but to huge numbers of viable, free-floating lymphoma cells. Thus, the first cell culture of Burkitt lymphoma was achieved, designated EB cells. In 1964, using electron microscopy, Anthony Epstein and his research assistant
389:
in 1961 about this newly described cancer, Epstein changed his research focus from cancer-causing viruses in chickens to searching for a viral origin of
Burkitt's lymphoma. After more than two years of working with tumour cells from Burkitt's patients and subsequently working to isolate a virus from
393:
In a tribute to
Epstein in his 100th year, the European Association for Haematopathology noted that his "perseverance, rigorous scientific observations and a bit of serendipity" resulted in the first cell culture in suspension from human lymphocytes. In 1963, a flight from Uganda was supposed to
398:
discovered viral particles in EB cells, resulting in the seminal paper published in 1964, "Virus particles in cultured lymphoblasts from
Burkitt's lymphoma" by Epstein, Achong and Barr. This was the first demonstration of viral particles in a human tumour.
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In 1950, Epstein married
Lisbeth Knight. Together they had three children: a daughter and two sons. They separated in 1965. In later life, his long-term partner was the virologist Kate Ward.
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638:"Interaction of Epstein–Barr virus with leukaemic B cells in vitro. I. Abortive infection and rare cell line establishment from chronic lymphocytic leukaemic cells"
846:
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548:"The abnormal cytotoxic T cell response to Epstein–Barr virus in rheumatoid arthritis was correlated with disease activity and occurs in other arthropathies"
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679:"Inhibition of the in vitro outgrowth of Epstein–Barr virus-transformed lymphocytes by thymus-dependent lymphocytes from infectious mononucleosis patients"
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761:"Not all potently neutralizing, vaccine-induced antibodies to Epstein-Barr virus ensure protection of susceptible experimental animals"
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489:"Purified Epstein-Barr virus Mr 340,000 glycoprotein induces potent virus-neutralizing antibodies when incorporated in liposomes"
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https://www.european-association-for-haematopathology.org/wp-content/uploads/2021/05/Anthony-Epstein-100th-anniversary.pdf
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1233:"Sir Anthony Epstein, pathologist who discovered the first virus known to cause cancer – obituary"
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in May 2021. He died on 6 February 2024 at his home in London, at the age of 102.
17:
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Epstein, A. (2012). "Burkitt
Lymphoma and the discovery of Epstein–Barr virus".
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Proceedings of the
National Academy of Sciences of the United States of America
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Bornkamm, G. W.; Delius, H.; Zimber, U.; Hudewentz, J.; Epstein, M. A. (1980).
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338:, from 1986 until 2001, and was an honorary fellow from 2001 until his death.
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was a cancer caused by a virus. Upon hearing a lecture given by surgeon
345:(FRS) and was its vice-president from 1986 to 1991. He was awarded its
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them, the
Epstein–Barr virus was finally discovered in February 1964.
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North, J. R.; Morgan, A. J.; Thompson, J. L.; Epstein, M. A. (1982).
759:
Epstein, M. A.; Randle, B. J.; Finerty, S.; Kirkwood, J. K. (1986).
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Yao, Q. Y.; Rickinson, A. B.; Gaston, J. S.; Epstein, M. A. (1986).
546:
Gaston, J. S.; Rickinson, A. B.; Yao, Q. Y.; Epstein, M. A. (1986).
30:
This article is about the scientist. For the
American judge, see
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The
Palgrave Dictionary of Anglo-Jewish History (2011), p. 258
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Fellows of the Academy of Medical Sciences (United Kingdom)
302:
Epstein was born in London on 18 May 1921, and educated at
677:
Rickinson, A. B.; Crawford, D.; Epstein, M. A. (1977).
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Rickinson, A. B.; Finerty, S.; Epstein, M. A. (1982).
326:(1968–1985) and head of department (1968–1982) at the
282:and academic. He was one of the discoverers of the
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1145:"Cancer virus discovery helped by delayed flight"
1114:"The 100th birthday of Prof. Sir Anthony Epstein"
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278:(18 May 1921 – 6 February 2024) was a British
1378:Commanders of the Order of the British Empire
901:Transactions of the Medical Society of London
381:Epstein was the first person to propose that
8:
365:. Epstein was also a founding Fellow of the
351:Commander of the Order of the British Empire
1348:People educated at St Paul's School, London
1323:Epstein-Barr virus, Sir Anthony Epstein FRS
1053:(Supplement). 28 December 1990. p. 1.
192:Paul Ehrlich and Ludwig Darmstaedter Prize
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953:"Obituary: Sir Anthony Epstein 1921-2024"
915:Who's Who: Epstein, Sir (Michael) Anthony
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959:. University of Oxford. 12 February 2024
369:in 1998. In 2006, Epstein was awarded a
839:"Professor Sir Anthony Epstein CBE FRS"
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1363:Academics of the University of Bristol
1032:(Supplement). 14 June 1985. p. 8.
595:Epstein, M. A.; Morgan, A. J. (1983).
1271:from the original on 10 February 2024
1212:"Anthony Epstein 100th Anniversary."
991:from the original on 22 December 2015
816:from the original on 17 November 2015
7:
1353:Alumni of Trinity College, Cambridge
1124:from the original on 31 October 2021
1075:from the original on 7 November 2017
879:from the original on 13 October 2020
849:from the original on 25 October 2021
765:Clinical and Experimental Immunology
724:Clinical and Experimental Immunology
683:Clinical and Experimental Immunology
642:Clinical and Experimental Immunology
601:Clinical and Experimental Immunology
1151:from the original on 8 October 2015
1094:EBV Association: Sir Antony Epstein
898:London, Medical Society of (2000).
25:
312:Middlesex Hospital Medical School
166:
128:Middlesex Hospital Medical School
1184:10.1111/j.1365-2141.2011.09008.x
904:. Harrison and Sons. p. 66.
552:Annals of the Rheumatic Diseases
1358:20th-century British biologists
1260:"Professor Sir Anthony Epstein"
1143:McGrath, Paula (6 April 2014).
349:in 1992. Epstein was appointed
162:
1172:British Journal of Haematology
27:British virologist (1921–2024)
1:
980:"Royal Medal – Award winners"
935:"Sir Michael Anthony Epstein"
456:10.1128/JVI.35.3.603-618.1980
1388:Fellows of the Royal Society
367:Academy of Medical Sciences
343:Fellow of the Royal Society
263:Sir Michael Anthony Epstein
1439:
373:(DSc) degree by Bristol.
308:Trinity College, Cambridge
123:Trinity College, Cambridge
29:
1393:Jewish British scientists
999:– via Google Drive.
341:In 1979 he was elected a
322:Epstein was Professor of
256:
213:
1403:British men centenarians
377:Burkitt lymphoma studies
304:St Paul's School, London
110:St Paul's School, London
1099:25 October 2021 at the
920:25 October 2021 at the
873:Wolfson College, Oxford
514:10.1073/pnas.79.23.7504
403:Personal life and death
336:Wolfson College, Oxford
71:Michael Anthony Epstein
1413:Scientists from London
1021:United Kingdom list:
869:"Sir Anthony Epstein"
564:10.1136/ard.45.11.932
387:Denis Parsons Burkitt
363:1991 New Year Honours
355:1985 Birthday Honours
328:University of Bristol
238:University of Bristol
1293:(15 February 2024).
1267:. 10 February 2024.
1147:. BBC News, Health.
1042:United Kingdom list:
165: 1950;
1418:Jewish centenarians
1408:Royal Medal winners
1373:British virologists
1299:The Washington Post
1219:17 May 2022 at the
505:1982PNAS...79.7504N
444:Journal of Virology
417:He was a Patron of
1239:. 11 February 2024
1065:"Epstein, Anthony"
1050:The London Gazette
1029:The London Gazette
383:Burkitt's lymphoma
284:Epstein–Barr virus
141:Epstein–Barr virus
32:Anthony C. Epstein
18:Michael A. Epstein
1368:British humanists
1069:Academy of Europe
806:"Anthony Epstein"
499:(23): 7504–7508.
371:Doctor of Science
260:
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247:Doctoral students
215:Scientific career
16:(Redirected from
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843:Humanists UK
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95:(2024-02-06)
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1343:2024 deaths
1338:1921 births
1304:16 February
1275:10 February
1243:19 February
1045:"No. 52382"
1024:"No. 50154"
963:19 February
396:Bert Achong
347:Royal Medal
330:. He was a
292:Bert Achong
288:Yvonne Barr
280:pathologist
251:Yvonne Barr
204:Royal Medal
81:18 May 1921
1332:Categories
1155:4 November
1128:31 October
1079:25 October
995:25 October
883:25 October
853:25 October
820:25 October
425:References
412:turned 100
298:Early life
77:1921-05-18
1265:The Times
324:Pathology
106:Education
1269:Archived
1217:Archived
1200:27417152
1192:22233499
1149:Archived
1122:Archived
1097:Archived
1073:Archived
989:Archived
918:Archived
877:Archived
847:Archived
814:Archived
410:Epstein
359:knighted
225:Virology
177:Children
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778:1577551
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737:1542331
696:1540876
664:6295671
655:1536694
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614:1535689
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573:1002022
533:6296836
501:Bibcode
474:6252328
361:in the
275:FMedSci
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357:, and
332:fellow
318:Career
310:; and
221:Fields
206:(1992)
200:(1991)
194:(1973)
185:Awards
147:Spouse
1196:S2CID
273:
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529:PMID
470:PMID
290:and
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90:Died
67:Born
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560:doi
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