1222:(Galβ1-3GalNAcα1-Ser/Thr) and negatively charged (NeuAcα2-3Galβ1-3GalNAcα1α1-Ser/Thr) sugar groups. About two thirds of these sugar groups are capped with sialic acid, and the end domains of the glycoprotein are thought to be globular, due to the nature of their protein-like domains. The N-terminus of lubricin is associated with its SMB-like domains, whereas the C-terminus is associated with the hemopexin-like domain. Due to the protein's overall slight negative charge and the fact that the center of the protein carries negatively charged sugar groups, the two end domains are thought to carry much of the protein's positive charge.
255:
232:
1242:
a number of studies have been conducted to mimic this. Researchers have successfully designed low-friction polymers imitating lubricin's bottle-brush-like structure, further supporting the notion that it is lubricin's architecture which plays an important role in reducing friction. Similarly, another study on zwitterionic polymer brushes, which intended to mimic the structure of bottle-brush polymers present in cartilage, found that the brushes produced super low fouling surfaces and super low friction surfaces.
129:
154:
1105:
1226:
506:
261:
160:
1218:, as both of these proteins contain a somatomedin B-like (SMB) domain and a hemopexin-like chain. These domains play a unique role in cell-cell and cell-extracellular matrix interactions. However, unlike vitronectin, lubricin carries a central mucin-like domain with a large number of repeating KEPAPTT motifs.
1241:
Shear studies of lubricin adsorbed between various hydrophilic and hydrophobic surfaces have confirmed the importance of the glycoprotein in boundary lubrication and wear protection in articular joints. Lubricin's bottle brush structure is common among a number of human lubricating glycoproteins, and
1497:
Flannery CR, Hughes CE, Schumacher BL, Tudor D, Aydelotte MB, Kuettner KE, Caterson B (January 1999). "Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growth-promoting, cytoprotective,
1233:
Lubricin's complex protein structure is termed "bottle brush," which refers to the large number of densely packed glycosylations on lubricin's backbone. Overall, lubricin's structure is similar to other mucin proteins and bottle brush polymers. This structure is key to its lubricating ability, which
1060:
growth, the gene responsible for the expression of lubricin was initially called "megakaryocyte-stimulating factor" (MSF). However, Lubricin, MSF, and SZP are now collectively known as
Proteoglycan 4 (hence PRG4 for the gene nomenclature). The evidence that lubricin is actually a proteoglycan is not
1237:
Furthermore, lubricin's N-terminus is thought to create disulfide bonds between two lubricin monomers. The glycoprotein thus exists as both a monomer and a dimer. The adsorption of lubricin to cartilage surfaces occurs through interactions on its N- and C- terminus, where its bottle brush structure
3381:
Lambiase A, Sullivan BD, Schmidt TA, Sullivan DA, Jay GD, Truitt ER, et al. (January 2017). "A Two-Week, Randomized, Double-masked Study to
Evaluate Safety and Efficacy of Lubricin (150 μg/mL) Eye Drops Versus Sodium Hyaluronate (HA) 0.18% Eye Drops (Vismed®) in Patients with Moderate Dry Eye
1108:
The adhesion of
Lubricin's N- (blue) and C- (red) termini to two opposing cartilage surfaces undergoing shear stress (𝜏) and normal forces (𝐹_𝑁). Steric repulsion between mucin domains and hydration forces of the trapped solvent layer are thought to give lubricin its characteristic lubrication
1328:
has been shown to exhibit reduced levels of lubricin when compared to healthy patients. Researchers are currently exploring potential applications of lubricin for treating these and other related diseases. Thus far, adding supplement lubricin has been shown to restore the lubricating ability of
1221:
In total, lubricin is approximately 200 nm +/- 50 nm in length and has a diameter of a few nanometers. The glycoprotein consists of >5% serine and >20% threonine residues, which give rise to a large number of O-glycosylations. These are thought to contain short polar
1124:
Early work on lubricin showed that it was able to lubricate non cartilaginous surfaces as effectively as whole synovial fluid, confirming its important biological lubrication role. Understanding lubricin is key to understanding joint mechanics and friction-based diseases.
1329:
synovial fluid from patients with established osteoarthritis. Lubricin has been shown to also play a role in anti-inflammation for osteoarthritis patients. Additionally, reduced lubricin levels have also been observed in the synovial fluid of patients with
1234:
is ascribed to interchain repulsion. This leads to trapping of large quantities of solvent and the stabilization of a fluid-like cushioning layer, which enables bottle brush polymers to lower the friction between joints when external pressure is applied.
2099:
Su JL, Schumacher BL, Lindley KM, Soloveychik V, Burkhart W, Triantafillou JA, et al. (June 2001). "Detection of superficial zone protein in human and animal body fluids by cross-species monoclonal antibodies specific to superficial zone protein".
1238:
plays a role in both coating and repelling similarly coated cartilage surfaces due to steric repulsion. Lubricin's high degree of hydration is also thought to be involved in repulsion forces generated by lubricin between opposing cartilage surfaces.
3214:
Ludwig TE, McAllister JR, Lun V, Wiley JP, Schmidt TA (December 2012). "Diminished cartilage-lubricating ability of human osteoarthritic synovial fluid deficient in proteoglycan 4: Restoration through proteoglycan 4 supplementation".
3456:
Morawietz L, Gehrke T, Frommelt L, Gratze P, Bosio A, Möller J, et al. (July 2003). "Differential gene expression in the periprosthetic membrane: lubricin as a new possible pathogenetic factor in prosthesis loosening".
1194:
measurements show that the lubricin molecule is a partially extended flexible rod and, in solution, occupies a smaller spatial domain than would be expected from structural predictions. The large glycosylated region (i. e
1316:
application has been shown to induce an increased lubricin expression in tendons and septa of rat hindlimbs, which might suggest a beneficial lubricating effect for joints and tissues prone to wear and tear degradation.
1453:
Marcelino J, Carpten JD, Suwairi WM, Gutierrez OM, Schwartz S, Robbins C, et al. (November 1999). "CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome".
1296:
for autosomal recessive camptodactyly-arthropathy-coxa vara-pericarditis syndrome maps to chromosome 1q25-q31 where the PRG4 gene is located. Cell overgrowth may be primary to the pathogenesis of this protein.
3002:
Merberg DM et al. (1993) Comparison of vitronectin and megakaryocyte stimulating factor. In
Biology of Vitronectins and their Receptors. (Preissner et al., eds) pp45-52 (Elsevier Science, Amsterdam).
1692:
Rees SG, Davies JR, Tudor D, Flannery CR, Hughes CE, Dent CM, Caterson B (November 2002). "Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon".
3494:
Liu YJ, Lu SH, Xu B, Yang RC, Ren Q, Liu B, et al. (June 2004). "Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages".
3875:
2733:
Zappone B, Greene GW, Oroudjev E, Jay GD, Israelachvili JN (February 2008). "Molecular aspects of boundary lubrication by human lubricin: effect of disulfide bonds and enzymatic digestion".
1275:
1554:
Schumacher BL, Block JA, Schmid TM, Aydelotte MB, Kuettner KE (May 1994). "A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage".
3728:"Cartilaginous deposits in subchondral bone in regions of exposed bone in osteoarthritis of the human knee: histomorphometric study of PRG4 distribution in osteoarthritic cartilage"
3012:
Taguchi M, Sun YL, Zhao C, Zobitz ME, Cha CJ, Jay GD, et al. (January 2008). "Lubricin surface modification improves extrasynovial tendon gliding in a canine model in vitro".
1053:. When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Due to the discovery that the 32-kDa amino terminal fragment of lubricin could stimulate
1618:
Biology of vitronectins and their receptors : proceedings of the First
International Vitronectin Workshop, Rauischholzhausen Castle, Marburg, Germany, 25-28 August, 1993
3200:
268:
167:
1649:
Lord MS, Estrella RP, Chuang CY, Youssef P, Karlsson NG, Flannery CR, Whitelock JM (2012). "Not all lubricin isoforms are substituted with a glycosaminoglycan chain".
5790:
3868:
2927:
Banquy X, Burdyńska J, Lee DW, Matyjaszewski K, Israelachvili J (April 2014). "Bioinspired bottle-brush polymer exhibits low friction and
Amontons-like behavior".
6750:
1207:
that improves its lubricating property. Lubricin's unglycosylated regions can interact with cartilage proteins. This characteristic may aid in the molecule's
6406:
5554:
1229:
The basic "bottle brush" structure of lubricin, including its mucin, hemopexin-like and somatomedin B (SMB)-like domains. Figure created with BioRender.com
5171:
3861:
2023:
Jay GD, Lane BP, Sokoloff L (January 1992). "Characterization of a bovine synovial fluid lubricating factor. III. The interaction with hyaluronic acid".
90:
704:
685:
3047:
Zhang D, Kearney CJ, Cheriyan T, Schmid TM, Spector M (November 2011). "Extracorporeal shockwave-induced expression of lubricin in tendons and septa".
5229:
6091:
5781:
5386:
1727:
Schumacher BL, Schmidt TA, Voegtline MS, Chen AC, Sah RL (May 2005). "Proteoglycan 4 (PRG4) synthesis and immunolocalization in bovine meniscus".
1589:
Jay GD, Britt DE, Cha CJ (March 2000). "Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts".
1771:
Ikegawa S, Sano M, Koshizuka Y, Nakamura Y (2000). "Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes".
6817:
4371:
4054:
1340:
Lubricin, which is naturally present in human cornea-eyelid interface, has also been shown to play a key role in reducing friction between the
3252:"Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury"
6769:
6719:
6690:
6637:
5124:
4991:
1432:
1414:
6807:
6448:
6444:
6440:
6436:
3989:
3973:
2467:
Jay GD, Harris DA, Cha CJ (October 2001). "Boundary lubrication by lubricin is mediated by O-linked beta(1-3)Gal-GalNAc oligosaccharides".
3151:"The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid"
4717:
4636:
4503:
4420:
944:
254:
6432:
2513:
Schmidt TA, Plaas AH, Sandy JD (May 2009). "Disulfide-bonded multimers of proteoglycan 4 PRG4 are present in normal synovial fluids".
951:
3829:
1308:
plus lubricin significantly lowered the gliding resistance of the tendons. This research can aid in improving the gliding ability of
6121:
5240:
4800:
4411:
1625:
231:
1540:
4069:
4013:
4004:
1313:
2393:"Molecular synergy in biolubrication: The role of cartilage oligomeric matrix protein (COMP) in surface-structuring of lubricin"
2142:"The O-glycomap of lubricin, a novel mucin responsible for joint lubrication, identified by site-specific glycopeptide analysis"
6643:
2352:"Cartilage oligomeric matrix protein forms protein complexes with synovial lubricin via non-covalent and covalent interactions"
1401:
1380:
2770:"Lubricin binds cartilage proteins, cartilage oligomeric matrix protein, fibronectin and collagen II at the cartilage surface"
6730:
6706:
5846:
5402:
5265:
3439:
3423:"The camptodactyly-arthropathy-coxa vara-pericarditis syndrome: clinical features and genetic mapping to human chromosome 1"
3422:
2589:
Radin EL, Swann DA, Weisser PA (October 1970). "Separation of a hyaluronate-free lubricating fraction from synovial fluid".
1397:
153:
128:
6696:
3841:
2825:
Briscoe WH, Titmuss S, Tiberg F, Thomas RK, McGillivray DJ, Klein J (November 2006). "Boundary lubrication under water".
1376:
6740:
5136:
5018:
5008:
3092:"Articular Joint Lubricants during Osteoarthritis and Rheumatoid Arthritis Display Altered Levels and Molecular Species"
70:
3607:"Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing"
2550:"Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing"
6086:
3301:"PA41 Traumatized knee joint synovial fluid fails to provide boundary lubrication among emergency department patients"
1286:
1251:
6111:
267:
166:
6725:
4551:
1330:
6106:
1304:
has also been studied. While adding lubricin alone fails to affect the tendon gliding resistance, the addition of
6633:
3642:"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry"
260:
159:
3090:
Kosinska MK, Ludwig TE, Liebisch G, Zhang R, Siebert HC, Wilhelm J, et al. (2015-05-01). Gualillo O (ed.).
1968:"Adsorption, lubrication, and wear of lubricin on model surfaces: polymer brush-like behavior of a glycoprotein"
1814:
Sun Y, Berger EJ, Zhao C, An KN, Amadio PC, Jay G (2006). "Mapping lubricin in canine musculoskeletal tissues".
4817:
4733:
4652:
4519:
4436:
749:
78:
4251:
1141:, and also by synovial lining cells. The cDNA encodes a protein of 1,404 amino acids (human A isoform) with a
6417:
4164:
4039:
730:
6096:
6812:
6701:
6317:
6221:
6081:
5841:
5260:
4246:
3884:
1180:
1162:
6775:
4972:
4616:
4256:
3895:
3194:
2196:"The molecular structure of lubricating glycoprotein-I, the boundary lubricant for articular cartilage"
1117:
family and similarly plays important roles in protecting cartilage surface from protein deposition and
1914:"The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth"
6715:
6101:
5033:
4982:
3782:
3544:
3103:
2834:
2781:
2707:
2598:
2404:
2248:
1979:
1321:
1208:
142:
5851:
3926:
1301:
57:
5856:
5270:
4967:
4159:
3847:
3835:
3334:"Transcription, translation, and function of lubricin, a boundary lubricant, at the ocular surface"
2237:"Galectin-3 Binds to Lubricin and Reinforces the Lubricating Boundary Layer of Articular Cartilage"
1191:
1138:
923:
898:
894:
890:
886:
856:
835:
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827:
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4892:
3605:
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2548:
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6474:
6387:
6332:
6286:
6231:
5966:
5906:
5534:
4907:
4837:
4396:
3994:
3936:
3887:
3757:
3714:
3519:
3482:
3072:
2962:
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2858:
2680:
2622:
2492:
1863:"Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activity"
1839:
1796:
1752:
1674:
1479:
1066:
102:
6469:
6347:
6246:
6032:
5921:
5721:
5681:
5429:
5348:
5210:
5151:
5113:
5058:
5053:
5043:
4917:
4912:
4882:
4857:
4852:
4842:
4728:
4647:
4586:
4514:
4493:
4478:
4431:
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3531:
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1104:
927:
902:
860:
819:
6569:
6427:
6362:
6342:
6261:
6241:
5956:
5936:
5916:
5559:
4887:
4611:
4144:
3941:
2350:
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6382:
6337:
6291:
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6236:
6161:
6060:
6027:
6007:
5971:
5961:
5911:
5871:
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3706:
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3572:
3511:
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2005:
1943:
1894:
1831:
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1631:
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1515:
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1026:
50:
6352:
6251:
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6050:
6002:
5995:
5981:
5926:
5896:
5376:
5366:
5318:
5300:
5063:
4902:
4847:
3149:
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6579:
5711:
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3111:
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3021:
2975:
2936:
2899:
2889:
2842:
2797:
2789:
2742:
2715:
2664:
2606:
2561:
2522:
2476:
2449:
2412:
2363:
2319:
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2264:
2256:
2207:
2163:
2153:
2109:
2071:
2032:
1995:
1987:
1933:
1925:
1884:
1874:
1823:
1780:
1736:
1701:
1658:
1563:
1507:
1463:
1353:
1309:
1293:
1255:
1109:
ability. Two glycoprotein monomers are linked by a disulfide bond in yellow to form a dimer.
347:
278:
222:
177:
17:
5103:
2292:
Flowers SA, Thomsson KA, Ali L, Huang S, Mthembu Y, Regmi SC, et al. (November 2020).
2235:
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1349:
1121:, in inhibiting synovial cell overgrowth, and in preventing cartilage-cartilage adhesion.
505:
322:
98:
1133:
The protein encoded by this gene is a approximately 345 kDa specifically synthesized by
3786:
3548:
3107:
2838:
2785:
2711:
2602:
2408:
2298:
glycans on synovial lubricin in osteoarthritis reduces galectin-3 mediated crosslinking"
2252:
1983:
6765:
6686:
6628:
6322:
6171:
6166:
5280:
5275:
3921:
3911:
3906:
3805:
3770:
3666:
3641:
3358:
3333:
3276:
3251:
3177:
3150:
3126:
3091:
2904:
2877:
2802:
2769:
2453:
2324:
2293:
2269:
2236:
2168:
2141:
2000:
1967:
1889:
1862:
1325:
1200:
1038:
3567:
3532:
3332:
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1913:
1912:
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1705:
1333:
injuries, and decreased lubricating ability has been found in patients with traumatic
1225:
1061:
solid. The expression of lubricin has also been detected and the protein localized in
619:
614:
609:
604:
599:
583:
578:
573:
557:
552:
547:
6801:
6459:
6372:
6301:
6271:
6206:
6116:
6070:
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4591:
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1843:
1800:
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6785:
6755:
6494:
6484:
6377:
6276:
6131:
5951:
5886:
5801:
5305:
5108:
4947:
4942:
4862:
4812:
4626:
4380:
4361:
4340:
4311:
4034:
4029:
3761:
3523:
2862:
2626:
1756:
1678:
1271:
1172:
1011:
340:
119:
1740:
3116:
2526:
2076:
2059:
1662:
106:
6745:
6711:
6609:
6599:
6594:
6584:
6534:
6357:
6256:
6017:
5931:
5861:
5756:
5519:
5484:
5434:
5397:
5333:
5215:
5146:
5098:
5088:
5083:
5078:
4962:
4957:
4952:
4330:
4241:
4231:
4199:
4194:
4189:
4184:
4174:
4134:
4099:
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3775:
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3537:
Proceedings of the National Academy of Sciences of the United States of America
3507:
3395:
2878:"Regulation of lubricin for functional cartilage tissue regeneration: a review"
2793:
2417:
2392:
2368:
2351:
2113:
423:
6564:
6529:
6524:
6514:
6504:
6422:
6211:
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6022:
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5836:
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5514:
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2894:
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2036:
1827:
1204:
1098:
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136:
86:
3640:
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2314:
2140:
Ali L, Flowers SA, Jin C, Bennet EP, Ekwall AK, Karlsson NG (December 2014).
1635:
558:
extracellular matrix structural constituent conferring compression resistance
6589:
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6549:
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6539:
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6489:
6181:
6141:
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5746:
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5731:
5652:
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5524:
5504:
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5353:
5328:
5093:
5013:
4932:
4877:
4767:
4706:
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2158:
1879:
1334:
1283:
1279:
1267:
1154:
1042:
649:
483:
361:
306:
293:
205:
192:
94:
3814:
3753:
3710:
3675:
3632:
3623:
3606:
3597:
3584:
de Haan G (February 2005). "A novel growth factor encoded by an old gene".
3576:
3515:
3478:
3403:
3367:
3285:
3236:
3186:
3135:
3068:
3033:
2989:
2948:
2913:
2854:
2811:
2754:
2676:
2575:
2566:
2549:
2534:
2488:
2426:
2377:
2333:
2278:
2177:
2121:
2085:
2009:
1947:
1898:
1835:
1792:
1748:
1713:
1670:
1602:
1567:
1511:
1475:
3448:
2618:
2221:
2044:
1575:
1519:
991:
986:
6760:
6479:
6136:
5736:
5726:
5706:
5641:
5610:
5579:
5543:
5449:
5439:
4786:
4266:
4209:
4119:
4079:
3025:
1086:
1054:
975:
794:
775:
2846:
2719:
6735:
6156:
5621:
5023:
3984:
1176:
1157:
domain, and an aggregation domain. There are 3 consensus sequences for
1146:
761:
716:
3744:
3727:
3701:
3684:
3657:
3267:
3228:
2980:
2963:
2940:
2746:
2345:
2343:
2260:
1966:
Zappone B, Ruths M, Greene GW, Jay GD, Israelachvili JN (March 2007).
1784:
6648:
6312:
6201:
6126:
5831:
5826:
5250:
5245:
5199:
5195:
5191:
5187:
5183:
5179:
5175:
4827:
4366:
4044:
2610:
2440:
Jay GD (October 2004). "Lubricin and surfacing of articular joints".
1929:
1341:
1090:
1062:
959:
671:
3771:"The role of lubricin in the mechanical behavior of synovial fluid"
3533:"Large-scale characterization of HeLa cell nuclear phosphoproteins"
3440:
10.1002/1529-0131(199804)41:4<730::AID-ART22>3.0.CO;2-Y
1250:
Lubricin, as MSF, was detected in the urine of patients undergoing
1097:. It is present in human plasma, where it binds to neutrophils via
6680:
6676:
6672:
6668:
6664:
6660:
6656:
6652:
6367:
6266:
5941:
5881:
5695:
5418:
5414:
5410:
5406:
4897:
4761:
4680:
4676:
4575:
4571:
4567:
4563:
4472:
4468:
4319:
3769:
Jay GD, Torres JR, Warman ML, Laderer MC, Breuer KS (April 2007).
1467:
1224:
1196:
1150:
1114:
1103:
1078:
1074:
1046:
1022:
634:
630:
6151:
4757:
4753:
4749:
4745:
4741:
4737:
4672:
4668:
4664:
4660:
4656:
4559:
4555:
4547:
4543:
4539:
4535:
4531:
4527:
4523:
4464:
4460:
4456:
4452:
4448:
4444:
4440:
4392:
4388:
4384:
4350:
4315:
4296:
3683:
Alazami AM, Al-Mayouf SM, Wyngaard CA, Meyer B (February 2006).
1094:
1082:
1070:
1018:
514:
74:
3857:
1258:. Depletion of lubricin function has also been associated with
1113:
Lubricin shares many properties with other members of the
2060:"The biology of lubricin: near frictionless joint motion"
2641:
330:
61:, CACP, HAPO, JCAP, MSF, SZP, bG174L6.2, proteoglycan 4
6751:
Pituitary adenylate cyclase-activating peptide (PACAP)
3685:"Novel PRG4 mutations underlie CACP in Saudi families"
3014:
The Journal of Bone and Joint Surgery. American Volume
2515:
Biochimica et Biophysica Acta (BBA) - General Subjects
1498:
and lubricating properties in cartilage metabolism".
495:
3726:
Zhang D, Johnson LJ, Hsu HP, Spector M (July 2007).
1175:
that consists of approximately equal proportions of
1041:
and on the surface (superficial layer) of articular
6618:
6405:
6300:
6069:
5809:
5800:
5780:
5694:
5671:
5640:
5609:
5578:
5542:
5533:
5385:
5228:
5161:
5123:
4990:
4981:
4799:
4776:
4716:
4635:
4502:
4419:
4410:
4349:
4295:
4208:
4012:
4003:
3972:
3894:
1500:
Biochemical and Biophysical Research Communications
916:
879:
849:
812:
6697:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
5555:Glial cell line-derived neurotrophic factor (GDNF)
5208:Cleavage products/derivatives with unknown target:
2964:"Electrostatically anchored branched brush layers"
1393:
1391:
1389:
1372:
1370:
1368:
1356:disease have thus far been relatively successful.
1320:Furthermore, the synovial fluid of patients with
277:
176:
6731:Macrophage-stimulating protein (MSP; HLP, HGFLP)
1448:
1446:
4372:Heparin-binding EGF-like growth factor (HB-EGF)
4055:Heparin-binding EGF-like growth factor (HB-EGF)
1179:and oligosaccharides. The oligosaccharides are
1398:GRCm38: Ensembl release 89: ENSMUSG00000006014
6783:Additional growth factor receptor modulators:
3869:
3199:: CS1 maint: DOI inactive as of April 2024 (
2194:Swann DA, Slayter HS, Silver FH (June 1981).
1203:protein. In synovial fluid it interacts with
8:
5137:Insulin-like growth factor-2 (somatomedin A)
5019:Insulin-like growth factor-2 (somatomedin A)
5009:Insulin-like growth factor-1 (somatomedin C)
2135:
2133:
2131:
1856:
1854:
1377:GRCh38: Ensembl release 89: ENSG00000116690
1161:-glycosylation and more than 168 sites for
5806:
5539:
4987:
4416:
4009:
3876:
3862:
3854:
1348:of the eye. Clinical trials of the use of
645:
530:
318:
217:
114:
3804:
3794:
3743:
3700:
3665:
3622:
3566:
3556:
3438:
3357:
3316:
3275:
3176:
3166:
3125:
3115:
2979:
2903:
2893:
2801:
2565:
2416:
2367:
2323:
2313:
2268:
2211:
2167:
2157:
2075:
1999:
1937:
1888:
1878:
1045:and therefore plays an important role in
6741:Migration-stimulating factor (MSF; PRG4)
3299:Jay GD, Zack J, Cha C (September 2001).
2929:Journal of the American Chemical Society
2397:Journal of Colloid and Interface Science
1535:
1533:
1531:
1529:
584:collagen-containing extracellular matrix
4070:Transforming growth factor alpha (TGFα)
1556:Archives of Biochemistry and Biophysics
1364:
1199:) of lubricin makes it a water-soluble
6644:Connective tissue growth factor (CTGF)
3192:
2876:Lee Y, Choi J, Hwang NS (2018-03-16).
1961:
1959:
1957:
31:
6707:Hepatoma-derived growth factor (HDGF)
2508:
2506:
2189:
2187:
1918:The Journal of Clinical Investigation
282:
243:
238:
181:
140:
135:
7:
1352:lubricin eye drops for treatment of
3611:The Journal of Biological Chemistry
2554:The Journal of Biological Chemistry
2302:The Journal of Biological Chemistry
2200:The Journal of Biological Chemistry
2146:Molecular & Cellular Proteomics
1867:The Journal of Biological Chemistry
470:medial head of gastrocnemius muscle
2454:10.1097/01.bco.0000136127.00043.a8
2058:Jay GD, Waller KA (October 2014).
1541:"Entrez Gene: PRG4 proteoglycan 4"
913:
876:
846:
809:
785:
766:
740:
721:
695:
676:
500:
418:
356:
335:
25:
1014:that in humans is encoded by the
6726:Leukemia inhibitory factor (LIF)
3350:10.1001/jamaophthalmol.2013.2385
3155:Arthritis Research & Therapy
1314:Extracorporeal shockwave therapy
504:
266:
259:
253:
230:
165:
158:
152:
127:
5894:Negative allosteric modulators:
3732:Journal of Orthopaedic Research
2442:Current Opinion in Orthopaedics
1729:Journal of Orthopaedic Research
6212:Gossypetin (3,5,7,8,3',4'-HHF)
5403:Platelet-derived growth factor
1773:Cytogenetics and Cell Genetics
1214:Lubricin is a close analog to
515:More reference expression data
484:More reference expression data
1:
6818:Extracellular matrix proteins
6418:Placental growth factor (PGF)
3318:10.1016/s1063-4584(01)80293-4
2213:10.1016/S0021-9258(19)69297-5
1741:10.1016/j.orthres.2004.11.011
1706:10.1016/S0945-053X(02)00056-2
1300:Lubricin’s role in improving
605:receptor-mediated endocytosis
600:cell population proliferation
251:
150:
27:Proteoglycan; lubricant; gene
6702:Glia maturation factor (GMF)
5211:Glypromate (GPE, (1-3)IGF-1)
3646:Journal of Proteome Research
3305:Osteoarthritis and Cartilage
3117:10.1371/journal.pone.0125192
2640:Created with Biorender.com.
2527:10.1016/j.bbagen.2009.03.016
2356:Osteoarthritis and Cartilage
2077:10.1016/j.matbio.2014.08.008
1663:10.3109/03008207.2011.614364
1620:. Elsevier. pp. 45–52.
18:Migration-stimulating factor
6808:Genes on human chromosome 1
3834:human gene location in the
1992:10.1529/biophysj.106.088799
1591:The Journal of Rheumatology
1252:bone marrow transplantation
1149:-binding domains, multiple
548:scavenger receptor activity
6834:
6634:Colony-stimulating factors
6626:Additional growth factors:
3846:human gene details in the
3508:10.1182/blood-2003-06-1825
3396:10.1016/j.jtos.2016.08.004
2794:10.1038/s41598-017-13558-y
2418:10.1016/j.jcis.2017.02.007
2369:10.1016/j.joca.2017.03.016
2114:10.1089/027245701750293475
2025:Connective Tissue Research
1816:Connective Tissue Research
1651:Connective Tissue Research
1137:located at the surface of
615:vesicle-mediated transport
5982:SNA-120 (pegylated K252a)
5154:(against IGF-1 and IGF-2)
5116:(against IGF-1 and IGF-2)
3471:10.1007/s00428-003-0818-y
3168:10.1186/s13075-015-0877-x
3061:10.1007/s00441-011-1258-7
2895:10.1186/s40824-018-0118-x
2037:10.3109/03008209209016818
1828:10.1080/03008200600846754
1433:"Mouse PubMed Reference:"
1415:"Human PubMed Reference:"
1254:during a period of acute
1049:lubrication and synovial
990:
985:
981:
974:
958:
952:Chr 1: 150.45 – 150.47 Mb
939:
920:
883:
872:
853:
816:
805:
792:
788:
773:
769:
760:
747:
743:
728:
724:
715:
702:
698:
683:
679:
670:
655:
648:
644:
628:
533:
529:
512:
503:
494:
481:
430:
421:
368:
359:
329:
321:
317:
300:
287:
250:
229:
220:
216:
199:
186:
149:
126:
117:
113:
68:
65:
55:
48:
43:
39:
34:
4818:Hepatocyte growth factor
4377:Neuregulins (heregulins)
4308:Neuregulins (heregulins)
4252:Trastuzumab duocarmazine
3965:(against angiopoietin 2)
3959:(against angiopoietin 3)
3427:Arthritis and Rheumatism
3256:Arthritis and Rheumatism
3217:Arthritis and Rheumatism
3049:Cell and Tissue Research
2315:10.1074/jbc.RA120.012882
945:Chr 1: 186.3 – 186.31 Mb
4165:Depatuxizumab mafodotin
3796:10.1073/pnas.0608558104
3558:10.1073/pnas.0404720101
3171:(inactive 2024-04-10).
2669:10.1126/science.1153273
2481:10.1023/a:1021159619373
2159:10.1074/mcp.M114.040865
1880:10.1074/jbc.M112.363119
1037:Lubricin is present in
6788:(neurotrophin mixture)
6776:Wnt signaling proteins
6457:Allosteric modulators:
6177:Norwogonin (5,7,8-THF)
4397:5 (tomoregulin, TMEFF)
4247:Trastuzumab deruxtecan
3885:Growth factor receptor
3624:10.1074/jbc.M505401200
2567:10.1074/jbc.M505401200
2469:Glycoconjugate Journal
1568:10.1006/abbi.1994.1219
1512:10.1006/bbrc.1998.0104
1230:
1186:both with and without
1110:
553:polysaccharide binding
6716:T-cell growth factors
4973:Telisotuzumab vedotin
4257:Trastuzumab emtansine
2882:Biomaterials Research
1616:Preissner KT (1993).
1246:Clinical significance
1228:
1166:-linked glycosylation
1107:
450:stroma of bone marrow
5301:EVT-901 (SAR-127963)
5034:Mecasermin rinfabate
3026:10.2106/JBJS.G.00045
2294:"Decrease of core 2
1322:rheumatoid arthritis
1209:boundary lubricating
1171:Lubricin is a large
579:extracellular matrix
574:extracellular region
245:Chromosome 1 (mouse)
143:Chromosome 1 (human)
3848:UCSC Genome Browser
3836:UCSC Genome Browser
3787:2007PNAS..104.6194J
3549:2004PNAS..10112130B
3108:2015PLoSO..1025192K
2847:10.1038/nature05196
2839:2006Natur.444..191B
2786:2017NatSR...713149F
2720:10.1021/ma60077a009
2712:1980MaMol..13.1069D
2603:1970Natur.228..377R
2409:2017JCIS..495..200R
2308:(47): 16023–16036.
2253:2016NatSR...625463R
1984:2007BpJ....92.1693Z
1972:Biophysical Journal
1192:Electron microscope
1139:articular cartilage
400:islet of Langerhans
396:germinal epithelium
392:right lobe of liver
6467:Kinase inhibitors:
6330:Kinase inhibitors:
6229:Kinase inhibitors:
5904:Kinase inhibitors:
5719:Kinase inhibitors:
5679:Kinase inhibitors:
5660:Kinase inhibitors:
5629:Kinase inhibitors:
5598:Kinase inhibitors:
5567:Kinase inhibitors:
5427:Kinase inhibitors:
5041:Kinase inhibitors:
4835:Kinase inhibitors:
4624:Kinase inhibitors:
4617:Aprutumab ixadotin
4264:Kinase inhibitors:
4077:Kinase inhibitors:
3934:Kinase inhibitors:
3384:The Ocular Surface
3338:JAMA Ophthalmology
2774:Scientific Reports
2241:Scientific Reports
1287:recessive disorder
1231:
1111:
750:ENSMUSG00000006014
593:Biological process
567:Cellular component
541:Molecular function
466:left lobe of liver
446:intercostal muscle
438:tibiofemoral joint
6795:
6794:
6401:
6400:
6162:N-Acetylserotonin
6061:ReN-1820 (TrkAd5)
5690:
5689:
5224:
5223:
5169:Binding proteins:
4828:Dihexa (PNB-0408)
4795:
4794:
4406:
4405:
4320:6 (neuroglycan C)
4040:EGF (urogastrone)
4018:
3745:10.1002/jor.20344
3702:10.1002/humu.9399
3658:10.1021/pr0502065
3268:10.1002/art.23495
3229:10.1002/art.34674
2981:10.1021/la3028989
2941:10.1021/ja501770y
2747:10.1021/la702383n
2261:10.1038/srep25463
1785:10.1159/000056791
1312:done clinically.
1153:-like repeats, a
1145:homology domain,
1001:
1000:
997:
996:
970:
969:
935:
934:
910:
909:
868:
867:
843:
842:
801:
800:
782:
781:
756:
755:
737:
736:
711:
710:
692:
691:
640:
639:
525:
524:
521:
520:
490:
489:
477:
476:
415:
414:
384:synovial membrane
313:
312:
212:
211:
16:(Redirected from
6825:
6607:Decoy receptors:
6580:Alacizumab pegol
6058:Decoy receptors:
5807:
5712:Stem cell factor
5653:Persephin (PSPN)
5591:Neurturin (NRTN)
5540:
5377:LEVI-04 (p75-Fc)
5374:Decoy receptors:
4988:
4417:
4016:
4010:
3878:
3871:
3864:
3855:
3818:
3808:
3798:
3765:
3747:
3722:
3704:
3679:
3669:
3636:
3626:
3617:(35): 31325–32.
3601:
3580:
3570:
3560:
3527:
3490:
3452:
3442:
3408:
3407:
3378:
3372:
3371:
3361:
3329:
3323:
3322:
3320:
3296:
3290:
3289:
3279:
3247:
3241:
3240:
3211:
3205:
3204:
3198:
3190:
3180:
3170:
3146:
3140:
3139:
3129:
3119:
3087:
3081:
3080:
3044:
3038:
3037:
3009:
3003:
3000:
2994:
2993:
2983:
2974:(44): 15537–47.
2959:
2953:
2952:
2935:(17): 6199–202.
2924:
2918:
2917:
2907:
2897:
2873:
2867:
2866:
2822:
2816:
2815:
2805:
2765:
2759:
2758:
2730:
2724:
2723:
2706:(5): 1069–1075.
2695:
2689:
2688:
2652:
2646:
2645:
2637:
2631:
2630:
2611:10.1038/228377a0
2586:
2580:
2579:
2569:
2560:(35): 31325–32.
2545:
2539:
2538:
2510:
2501:
2500:
2464:
2458:
2457:
2437:
2431:
2430:
2420:
2388:
2382:
2381:
2371:
2362:(9): 1496–1504.
2347:
2338:
2337:
2327:
2317:
2289:
2283:
2282:
2272:
2232:
2226:
2225:
2215:
2191:
2182:
2181:
2171:
2161:
2152:(12): 3396–409.
2137:
2126:
2125:
2096:
2090:
2089:
2079:
2055:
2049:
2048:
2020:
2014:
2013:
2003:
1963:
1952:
1951:
1941:
1930:10.1172/JCI22263
1909:
1903:
1902:
1892:
1882:
1873:(43): 35922–33.
1858:
1849:
1847:
1811:
1805:
1804:
1768:
1762:
1760:
1724:
1718:
1717:
1689:
1683:
1682:
1646:
1640:
1639:
1613:
1607:
1606:
1586:
1580:
1579:
1551:
1545:
1544:
1537:
1524:
1523:
1494:
1488:
1487:
1450:
1441:
1440:
1429:
1423:
1422:
1411:
1405:
1395:
1384:
1374:
1256:thrombocytopenia
1021:. It acts as a
983:
982:
954:
947:
930:
914:
905:
877:
873:RefSeq (protein)
863:
847:
838:
810:
786:
767:
741:
722:
696:
677:
646:
531:
517:
508:
501:
486:
454:semi-lunar valve
426:
424:Top expressed in
419:
404:popliteal artery
364:
362:Top expressed in
357:
336:
319:
309:
296:
285:
270:
263:
257:
246:
234:
218:
208:
195:
184:
169:
162:
156:
145:
131:
115:
109:
107:PRG4 - orthologs
60:
53:
32:
21:
6833:
6832:
6828:
6827:
6826:
6824:
6823:
6822:
6798:
6797:
6796:
6791:
6736:Midkine (NEGF2)
6614:
6397:
6296:
6065:
6003:ABT-110 (PG110)
5796:
5776:
5686:
5667:
5636:
5605:
5574:
5529:
5381:
5319:ABT-110 (PG110)
5220:
5157:
5119:
4977:
4791:
4772:
4712:
4709:(against FGF23)
4631:
4498:
4402:
4345:
4291:
4204:
4015:
3999:
3968:
3890:
3882:
3826:
3821:
3768:
3725:
3682:
3639:
3604:
3583:
3543:(33): 12130–5.
3530:
3502:(12): 4449–56.
3493:
3459:Virchows Archiv
3455:
3420:
3416:
3414:Further reading
3411:
3380:
3379:
3375:
3331:
3330:
3326:
3298:
3297:
3293:
3249:
3248:
3244:
3223:(12): 3963–71.
3213:
3212:
3208:
3191:
3148:
3147:
3143:
3102:(5): e0125192.
3089:
3088:
3084:
3046:
3045:
3041:
3011:
3010:
3006:
3001:
2997:
2961:
2960:
2956:
2926:
2925:
2921:
2875:
2874:
2870:
2833:(7116): 191–4.
2824:
2823:
2819:
2767:
2766:
2762:
2741:(4): 1495–508.
2732:
2731:
2727:
2697:
2696:
2692:
2663:(5863): 575–6.
2654:
2653:
2649:
2639:
2638:
2634:
2597:(5269): 377–8.
2588:
2587:
2583:
2547:
2546:
2542:
2512:
2511:
2504:
2466:
2465:
2461:
2439:
2438:
2434:
2390:
2389:
2385:
2349:
2348:
2341:
2291:
2290:
2286:
2234:
2233:
2229:
2193:
2192:
2185:
2139:
2138:
2129:
2098:
2097:
2093:
2057:
2056:
2052:
2022:
2021:
2017:
1978:(5): 1693–708.
1965:
1964:
1955:
1911:
1910:
1906:
1860:
1859:
1852:
1813:
1812:
1808:
1770:
1769:
1765:
1726:
1725:
1721:
1691:
1690:
1686:
1648:
1647:
1643:
1628:
1615:
1614:
1610:
1588:
1587:
1583:
1553:
1552:
1548:
1539:
1538:
1527:
1496:
1495:
1491:
1456:Nature Genetics
1452:
1451:
1444:
1431:
1430:
1426:
1413:
1412:
1408:
1396:
1387:
1375:
1366:
1362:
1248:
1131:
1035:
992:View/Edit Mouse
987:View/Edit Human
950:
943:
940:Location (UCSC)
926:
922:
901:
897:
893:
889:
885:
859:
855:
834:
830:
826:
822:
818:
731:ENSG00000116690
624:
610:immune response
588:
562:
513:
482:
473:
468:
464:
462:muscle of thigh
460:
456:
452:
448:
444:
440:
436:
422:
411:
408:tibial arteries
406:
402:
398:
394:
390:
388:parietal pleura
386:
382:
378:
376:Achilles tendon
374:
360:
304:
291:
283:
273:
272:
271:
264:
244:
221:Gene location (
203:
190:
182:
172:
171:
170:
163:
141:
118:Gene location (
69:
56:
49:
28:
23:
22:
15:
12:
11:
5:
6831:
6829:
6821:
6820:
6815:
6810:
6800:
6799:
6793:
6792:
6790:
6789:
6779:
6778:
6773:
6766:Thrombopoietin
6763:
6758:
6753:
6748:
6743:
6738:
6733:
6728:
6723:
6709:
6704:
6699:
6694:
6687:Erythropoietin
6684:
6646:
6641:
6631:
6629:Adrenomedullin
6622:
6620:
6616:
6615:
6613:
6612:
6603:
6602:
6597:
6592:
6587:
6582:
6573:
6572:
6567:
6562:
6557:
6552:
6547:
6542:
6537:
6532:
6527:
6522:
6517:
6512:
6507:
6502:
6497:
6492:
6487:
6482:
6477:
6472:
6463:
6462:
6453:
6452:
6430:
6425:
6420:
6411:
6409:
6403:
6402:
6399:
6398:
6396:
6395:
6390:
6385:
6380:
6375:
6370:
6365:
6360:
6355:
6350:
6345:
6340:
6335:
6326:
6325:
6320:
6315:
6306:
6304:
6298:
6297:
6295:
6294:
6289:
6284:
6279:
6274:
6269:
6264:
6259:
6254:
6249:
6244:
6239:
6234:
6225:
6224:
6215:
6214:
6209:
6204:
6195:
6194:
6189:
6184:
6179:
6174:
6169:
6164:
6159:
6154:
6149:
6144:
6139:
6134:
6129:
6124:
6119:
6114:
6109:
6104:
6099:
6094:
6092:4'-DMA-7,8-DHF
6089:
6084:
6075:
6073:
6067:
6066:
6064:
6063:
6054:
6053:
6041:
6040:
6035:
6030:
6025:
6020:
6015:
6010:
6005:
5986:
5985:
5979:
5974:
5969:
5964:
5959:
5954:
5949:
5944:
5939:
5934:
5929:
5924:
5919:
5914:
5909:
5900:
5899:
5890:
5889:
5884:
5879:
5874:
5865:
5864:
5859:
5854:
5852:Gambogic amide
5849:
5844:
5839:
5834:
5829:
5824:
5815:
5813:
5804:
5798:
5797:
5795:
5794:
5786:
5784:
5778:
5777:
5775:
5774:
5769:
5764:
5759:
5754:
5749:
5744:
5739:
5734:
5729:
5724:
5715:
5714:
5709:
5700:
5698:
5692:
5691:
5688:
5687:
5685:
5684:
5675:
5673:
5669:
5668:
5666:
5665:
5656:
5655:
5646:
5644:
5638:
5637:
5635:
5634:
5625:
5624:
5622:Artemin (ARTN)
5615:
5613:
5607:
5606:
5604:
5603:
5594:
5593:
5584:
5582:
5576:
5575:
5573:
5572:
5563:
5562:
5557:
5548:
5546:
5537:
5531:
5530:
5528:
5527:
5522:
5517:
5508:
5507:
5502:
5497:
5492:
5487:
5482:
5477:
5472:
5467:
5462:
5457:
5452:
5447:
5442:
5437:
5432:
5423:
5422:
5400:
5391:
5389:
5383:
5382:
5380:
5379:
5370:
5369:
5357:
5356:
5351:
5346:
5341:
5336:
5331:
5326:
5321:
5309:
5308:
5303:
5298:
5293:
5284:
5283:
5278:
5273:
5268:
5263:
5258:
5253:
5248:
5243:
5234:
5232:
5226:
5225:
5222:
5221:
5219:
5218:
5213:
5204:
5203:
5165:
5163:
5159:
5158:
5156:
5155:
5149:
5140:
5139:
5129:
5127:
5121:
5120:
5118:
5117:
5111:
5106:
5101:
5096:
5091:
5086:
5081:
5076:
5067:
5066:
5061:
5056:
5051:
5046:
5037:
5036:
5031:
5026:
5021:
5016:
5011:
5006:
4996:
4994:
4985:
4979:
4978:
4976:
4975:
4970:
4965:
4960:
4955:
4950:
4945:
4936:
4935:
4930:
4925:
4920:
4915:
4910:
4905:
4900:
4895:
4890:
4885:
4880:
4875:
4870:
4865:
4860:
4855:
4850:
4845:
4840:
4831:
4830:
4821:
4820:
4815:
4805:
4803:
4797:
4796:
4793:
4792:
4790:
4789:
4780:
4778:
4774:
4773:
4771:
4770:
4765:
4731:
4722:
4720:
4714:
4713:
4711:
4710:
4700:
4699:
4694:
4689:
4684:
4650:
4641:
4639:
4633:
4632:
4630:
4629:
4620:
4619:
4614:
4605:
4604:
4599:
4594:
4589:
4584:
4579:
4517:
4508:
4506:
4500:
4499:
4497:
4496:
4491:
4486:
4481:
4476:
4434:
4425:
4423:
4414:
4408:
4407:
4404:
4403:
4401:
4400:
4374:
4369:
4364:
4355:
4353:
4347:
4346:
4344:
4343:
4338:
4333:
4324:
4323:
4301:
4299:
4293:
4292:
4290:
4289:
4284:
4279:
4274:
4269:
4260:
4259:
4254:
4249:
4244:
4239:
4234:
4225:
4224:
4214:
4212:
4206:
4205:
4203:
4202:
4197:
4192:
4187:
4182:
4177:
4172:
4167:
4162:
4157:
4148:
4147:
4142:
4137:
4132:
4127:
4122:
4117:
4112:
4107:
4102:
4097:
4092:
4087:
4082:
4073:
4072:
4067:
4062:
4057:
4052:
4047:
4042:
4037:
4032:
4022:
4020:
4007:
4001:
4000:
3998:
3997:
3992:
3987:
3978:
3976:
3970:
3969:
3967:
3966:
3960:
3950:
3949:
3944:
3939:
3930:
3929:
3927:Angiopoietin 3
3924:
3922:Angiopoietin 2
3915:
3914:
3912:Angiopoietin 4
3909:
3907:Angiopoietin 1
3900:
3898:
3892:
3891:
3883:
3881:
3880:
3873:
3866:
3858:
3852:
3851:
3839:
3825:
3824:External links
3822:
3820:
3819:
3781:(15): 6194–9.
3766:
3723:
3689:Human Mutation
3680:
3652:(6): 2070–80.
3637:
3602:
3581:
3528:
3491:
3453:
3417:
3415:
3412:
3410:
3409:
3373:
3324:
3291:
3262:(6): 1707–15.
3242:
3206:
3141:
3082:
3039:
3004:
2995:
2954:
2919:
2868:
2817:
2760:
2725:
2700:Macromolecules
2690:
2647:
2632:
2581:
2540:
2502:
2475:(10): 807–15.
2459:
2448:(5): 355–359.
2432:
2383:
2339:
2284:
2227:
2206:(11): 5921–5.
2183:
2127:
2091:
2064:Matrix Biology
2050:
2015:
1953:
1904:
1850:
1806:
1779:(3–4): 291–7.
1763:
1719:
1700:(7): 593–602.
1694:Matrix Biology
1684:
1641:
1626:
1608:
1597:(3): 594–600.
1581:
1546:
1525:
1489:
1442:
1424:
1406:
1385:
1363:
1361:
1358:
1326:osteoarthritis
1302:tendon gliding
1247:
1244:
1201:synovial fluid
1130:
1127:
1039:synovial fluid
1034:
1031:
1004:Proteoglycan 4
999:
998:
995:
994:
989:
979:
978:
972:
971:
968:
967:
965:
963:
956:
955:
948:
941:
937:
936:
933:
932:
918:
917:
911:
908:
907:
881:
880:
874:
870:
869:
866:
865:
851:
850:
844:
841:
840:
814:
813:
807:
803:
802:
799:
798:
790:
789:
783:
780:
779:
771:
770:
764:
758:
757:
754:
753:
745:
744:
738:
735:
734:
726:
725:
719:
713:
712:
709:
708:
700:
699:
693:
690:
689:
681:
680:
674:
668:
667:
662:
657:
653:
652:
642:
641:
638:
637:
626:
625:
623:
622:
617:
612:
607:
602:
596:
594:
590:
589:
587:
586:
581:
576:
570:
568:
564:
563:
561:
560:
555:
550:
544:
542:
538:
537:
527:
526:
523:
522:
519:
518:
510:
509:
498:
492:
491:
488:
487:
479:
478:
475:
474:
472:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
428:
427:
416:
413:
412:
410:
409:
405:
401:
397:
393:
389:
385:
381:
377:
373:
372:synovial joint
369:
366:
365:
353:
352:
344:
333:
327:
326:
323:RNA expression
315:
314:
311:
310:
302:
298:
297:
289:
286:
281:
275:
274:
265:
258:
252:
248:
247:
242:
236:
235:
227:
226:
214:
213:
210:
209:
201:
197:
196:
188:
185:
180:
174:
173:
164:
157:
151:
147:
146:
139:
133:
132:
124:
123:
111:
110:
67:
63:
62:
54:
46:
45:
41:
40:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6830:
6819:
6816:
6814:
6813:Proteoglycans
6811:
6809:
6806:
6805:
6803:
6787:
6784:
6781:
6780:
6777:
6774:
6771:
6767:
6764:
6762:
6759:
6757:
6754:
6752:
6749:
6747:
6744:
6742:
6739:
6737:
6734:
6732:
6729:
6727:
6724:
6721:
6717:
6713:
6710:
6708:
6705:
6703:
6700:
6698:
6695:
6692:
6688:
6685:
6682:
6678:
6674:
6670:
6666:
6662:
6658:
6654:
6650:
6647:
6645:
6642:
6639:
6635:
6632:
6630:
6627:
6624:
6623:
6621:
6617:
6611:
6608:
6605:
6604:
6601:
6598:
6596:
6593:
6591:
6588:
6586:
6583:
6581:
6578:
6575:
6574:
6571:
6568:
6566:
6563:
6561:
6558:
6556:
6553:
6551:
6548:
6546:
6543:
6541:
6538:
6536:
6533:
6531:
6528:
6526:
6523:
6521:
6518:
6516:
6513:
6511:
6508:
6506:
6503:
6501:
6498:
6496:
6493:
6491:
6488:
6486:
6483:
6481:
6478:
6476:
6473:
6471:
6468:
6465:
6464:
6461:
6460:Cyclotraxin B
6458:
6455:
6454:
6450:
6446:
6442:
6438:
6434:
6431:
6429:
6426:
6424:
6421:
6419:
6416:
6413:
6412:
6410:
6408:
6404:
6394:
6391:
6389:
6386:
6384:
6381:
6379:
6376:
6374:
6373:Larotrectinib
6371:
6369:
6366:
6364:
6361:
6359:
6356:
6354:
6351:
6349:
6346:
6344:
6341:
6339:
6336:
6334:
6331:
6328:
6327:
6324:
6321:
6319:
6316:
6314:
6311:
6308:
6307:
6305:
6303:
6299:
6293:
6290:
6288:
6285:
6283:
6280:
6278:
6275:
6273:
6272:Larotrectinib
6270:
6268:
6265:
6263:
6260:
6258:
6255:
6253:
6250:
6248:
6245:
6243:
6240:
6238:
6235:
6233:
6230:
6227:
6226:
6223:
6220:
6217:
6216:
6213:
6210:
6208:
6207:Cyclotraxin B
6205:
6203:
6200:
6197:
6196:
6193:
6190:
6188:
6185:
6183:
6180:
6178:
6175:
6173:
6170:
6168:
6165:
6163:
6160:
6158:
6155:
6153:
6150:
6148:
6145:
6143:
6140:
6138:
6135:
6133:
6130:
6128:
6125:
6123:
6120:
6118:
6117:Amitriptyline
6115:
6113:
6110:
6108:
6105:
6103:
6100:
6098:
6095:
6093:
6090:
6088:
6085:
6083:
6080:
6077:
6076:
6074:
6072:
6068:
6062:
6059:
6056:
6055:
6052:
6049:
6046:
6043:
6042:
6039:
6036:
6034:
6031:
6029:
6026:
6024:
6021:
6019:
6016:
6014:
6011:
6009:
6006:
6004:
6001:
5997:
5994:
5993:Against TrkA:
5991:
5988:
5987:
5983:
5980:
5978:
5975:
5973:
5970:
5968:
5965:
5963:
5960:
5958:
5955:
5953:
5950:
5948:
5947:Larotrectinib
5945:
5943:
5940:
5938:
5935:
5933:
5930:
5928:
5925:
5923:
5920:
5918:
5915:
5913:
5910:
5908:
5905:
5902:
5901:
5898:
5895:
5892:
5891:
5888:
5885:
5883:
5880:
5878:
5877:Dexamethasone
5875:
5873:
5870:
5867:
5866:
5863:
5860:
5858:
5855:
5853:
5850:
5848:
5845:
5843:
5840:
5838:
5835:
5833:
5830:
5828:
5825:
5823:
5822:Amitriptyline
5820:
5817:
5816:
5814:
5812:
5808:
5805:
5803:
5799:
5792:
5788:
5787:
5785:
5783:
5779:
5773:
5770:
5768:
5765:
5763:
5760:
5758:
5755:
5753:
5750:
5748:
5745:
5743:
5740:
5738:
5735:
5733:
5730:
5728:
5725:
5723:
5720:
5717:
5716:
5713:
5710:
5708:
5705:
5702:
5701:
5699:
5697:
5693:
5683:
5680:
5677:
5676:
5674:
5670:
5664:
5661:
5658:
5657:
5654:
5651:
5648:
5647:
5645:
5643:
5639:
5633:
5630:
5627:
5626:
5623:
5620:
5617:
5616:
5614:
5612:
5608:
5602:
5599:
5596:
5595:
5592:
5589:
5586:
5585:
5583:
5581:
5577:
5571:
5568:
5565:
5564:
5561:
5558:
5556:
5553:
5550:
5549:
5547:
5545:
5541:
5538:
5536:
5532:
5526:
5523:
5521:
5518:
5516:
5513:
5510:
5509:
5506:
5503:
5501:
5498:
5496:
5493:
5491:
5488:
5486:
5483:
5481:
5478:
5476:
5473:
5471:
5468:
5466:
5463:
5461:
5458:
5456:
5453:
5451:
5448:
5446:
5443:
5441:
5438:
5436:
5433:
5431:
5428:
5425:
5424:
5420:
5416:
5412:
5408:
5404:
5401:
5399:
5396:
5393:
5392:
5390:
5388:
5384:
5378:
5375:
5372:
5371:
5368:
5365:
5362:
5359:
5358:
5355:
5352:
5350:
5347:
5345:
5342:
5340:
5337:
5335:
5332:
5330:
5327:
5325:
5322:
5320:
5317:
5314:
5311:
5310:
5307:
5304:
5302:
5299:
5297:
5296:Dexamethasone
5294:
5292:
5289:
5286:
5285:
5282:
5279:
5277:
5274:
5272:
5269:
5267:
5264:
5262:
5259:
5257:
5254:
5252:
5249:
5247:
5244:
5242:
5239:
5236:
5235:
5233:
5231:
5227:
5217:
5214:
5212:
5209:
5206:
5205:
5201:
5197:
5193:
5189:
5185:
5181:
5177:
5173:
5170:
5167:
5166:
5164:
5160:
5153:
5150:
5148:
5145:
5142:
5141:
5138:
5134:
5131:
5130:
5128:
5126:
5122:
5115:
5112:
5110:
5107:
5105:
5102:
5100:
5097:
5095:
5092:
5090:
5087:
5085:
5082:
5080:
5077:
5075:
5072:
5069:
5068:
5065:
5062:
5060:
5057:
5055:
5052:
5050:
5047:
5045:
5042:
5039:
5038:
5035:
5032:
5030:
5027:
5025:
5022:
5020:
5017:
5015:
5012:
5010:
5007:
5005:
5004:des(1-3)IGF-1
5001:
4998:
4997:
4995:
4993:
4989:
4986:
4984:
4980:
4974:
4971:
4969:
4968:Telisotuzumab
4966:
4964:
4961:
4959:
4956:
4954:
4951:
4949:
4946:
4944:
4941:
4938:
4937:
4934:
4931:
4929:
4926:
4924:
4921:
4919:
4916:
4914:
4911:
4909:
4906:
4904:
4901:
4899:
4896:
4894:
4891:
4889:
4886:
4884:
4881:
4879:
4876:
4874:
4871:
4869:
4866:
4864:
4861:
4859:
4856:
4854:
4851:
4849:
4846:
4844:
4841:
4839:
4836:
4833:
4832:
4829:
4826:
4825:Potentiators:
4823:
4822:
4819:
4816:
4814:
4810:
4807:
4806:
4804:
4802:
4798:
4788:
4785:
4782:
4781:
4779:
4775:
4769:
4766:
4763:
4759:
4755:
4751:
4747:
4743:
4739:
4735:
4732:
4730:
4727:
4724:
4723:
4721:
4719:
4715:
4708:
4705:
4702:
4701:
4698:
4695:
4693:
4690:
4688:
4687:Selpercatinib
4685:
4682:
4678:
4674:
4670:
4666:
4662:
4658:
4654:
4651:
4649:
4646:
4643:
4642:
4640:
4638:
4634:
4628:
4625:
4622:
4621:
4618:
4615:
4613:
4610:
4607:
4606:
4603:
4600:
4598:
4595:
4593:
4592:Selpercatinib
4590:
4588:
4585:
4583:
4580:
4577:
4573:
4569:
4565:
4561:
4557:
4553:
4549:
4545:
4541:
4537:
4533:
4529:
4525:
4521:
4518:
4516:
4513:
4510:
4509:
4507:
4505:
4501:
4495:
4492:
4490:
4487:
4485:
4484:Selpercatinib
4482:
4480:
4477:
4474:
4470:
4466:
4462:
4458:
4454:
4450:
4446:
4442:
4438:
4435:
4433:
4430:
4427:
4426:
4424:
4422:
4418:
4415:
4413:
4409:
4398:
4394:
4390:
4386:
4382:
4378:
4375:
4373:
4370:
4368:
4365:
4363:
4360:
4357:
4356:
4354:
4352:
4348:
4342:
4339:
4337:
4334:
4332:
4329:
4326:
4325:
4321:
4317:
4313:
4309:
4306:
4303:
4302:
4300:
4298:
4294:
4288:
4285:
4283:
4280:
4278:
4275:
4273:
4270:
4268:
4265:
4262:
4261:
4258:
4255:
4253:
4250:
4248:
4245:
4243:
4240:
4238:
4235:
4233:
4230:
4227:
4226:
4223:
4219:
4216:
4215:
4213:
4211:
4207:
4201:
4198:
4196:
4193:
4191:
4188:
4186:
4183:
4181:
4178:
4176:
4173:
4171:
4168:
4166:
4163:
4161:
4160:Depatuxizumab
4158:
4156:
4153:
4150:
4149:
4146:
4143:
4141:
4138:
4136:
4133:
4131:
4128:
4126:
4123:
4121:
4118:
4116:
4113:
4111:
4108:
4106:
4103:
4101:
4098:
4096:
4093:
4091:
4088:
4086:
4083:
4081:
4078:
4075:
4074:
4071:
4068:
4066:
4063:
4061:
4058:
4056:
4053:
4051:
4048:
4046:
4043:
4041:
4038:
4036:
4033:
4031:
4027:
4024:
4023:
4021:
4019:
4011:
4008:
4006:
4002:
3996:
3993:
3991:
3988:
3986:
3983:
3980:
3979:
3977:
3975:
3971:
3964:
3961:
3958:
3955:
3952:
3951:
3948:
3945:
3943:
3940:
3938:
3935:
3932:
3931:
3928:
3925:
3923:
3920:
3917:
3916:
3913:
3910:
3908:
3905:
3902:
3901:
3899:
3897:
3893:
3889:
3886:
3879:
3874:
3872:
3867:
3865:
3860:
3859:
3856:
3849:
3845:
3844:
3840:
3837:
3833:
3832:
3828:
3827:
3823:
3816:
3812:
3807:
3802:
3797:
3792:
3788:
3784:
3780:
3776:
3772:
3767:
3763:
3759:
3755:
3751:
3746:
3741:
3738:(7): 873–83.
3737:
3733:
3729:
3724:
3720:
3716:
3712:
3708:
3703:
3698:
3694:
3690:
3686:
3681:
3677:
3673:
3668:
3663:
3659:
3655:
3651:
3647:
3643:
3638:
3634:
3630:
3625:
3620:
3616:
3612:
3608:
3603:
3599:
3595:
3591:
3587:
3586:Haematologica
3582:
3578:
3574:
3569:
3564:
3559:
3554:
3550:
3546:
3542:
3538:
3534:
3529:
3525:
3521:
3517:
3513:
3509:
3505:
3501:
3497:
3492:
3488:
3484:
3480:
3476:
3472:
3468:
3464:
3460:
3454:
3450:
3446:
3441:
3436:
3432:
3428:
3424:
3419:
3418:
3413:
3405:
3401:
3397:
3393:
3389:
3385:
3377:
3374:
3369:
3365:
3360:
3355:
3351:
3347:
3344:(6): 766–76.
3343:
3339:
3335:
3328:
3325:
3319:
3314:
3310:
3306:
3302:
3295:
3292:
3287:
3283:
3278:
3273:
3269:
3265:
3261:
3257:
3253:
3246:
3243:
3238:
3234:
3230:
3226:
3222:
3218:
3210:
3207:
3202:
3196:
3188:
3184:
3179:
3174:
3169:
3164:
3160:
3156:
3152:
3145:
3142:
3137:
3133:
3128:
3123:
3118:
3113:
3109:
3105:
3101:
3097:
3093:
3086:
3083:
3078:
3074:
3070:
3066:
3062:
3058:
3055:(2): 255–62.
3054:
3050:
3043:
3040:
3035:
3031:
3027:
3023:
3020:(1): 129–35.
3019:
3015:
3008:
3005:
2999:
2996:
2991:
2987:
2982:
2977:
2973:
2969:
2965:
2958:
2955:
2950:
2946:
2942:
2938:
2934:
2930:
2923:
2920:
2915:
2911:
2906:
2901:
2896:
2891:
2887:
2883:
2879:
2872:
2869:
2864:
2860:
2856:
2852:
2848:
2844:
2840:
2836:
2832:
2828:
2821:
2818:
2813:
2809:
2804:
2799:
2795:
2791:
2787:
2783:
2779:
2775:
2771:
2764:
2761:
2756:
2752:
2748:
2744:
2740:
2736:
2729:
2726:
2721:
2717:
2713:
2709:
2705:
2701:
2694:
2691:
2686:
2682:
2678:
2674:
2670:
2666:
2662:
2658:
2651:
2648:
2643:
2636:
2633:
2628:
2624:
2620:
2616:
2612:
2608:
2604:
2600:
2596:
2592:
2585:
2582:
2577:
2573:
2568:
2563:
2559:
2555:
2551:
2544:
2541:
2536:
2532:
2528:
2524:
2521:(5): 375–84.
2520:
2516:
2509:
2507:
2503:
2498:
2494:
2490:
2486:
2482:
2478:
2474:
2470:
2463:
2460:
2455:
2451:
2447:
2443:
2436:
2433:
2428:
2424:
2419:
2414:
2410:
2406:
2402:
2398:
2394:
2387:
2384:
2379:
2375:
2370:
2365:
2361:
2357:
2353:
2346:
2344:
2340:
2335:
2331:
2326:
2321:
2316:
2311:
2307:
2303:
2299:
2297:
2288:
2285:
2280:
2276:
2271:
2266:
2262:
2258:
2254:
2250:
2246:
2242:
2238:
2231:
2228:
2223:
2219:
2214:
2209:
2205:
2201:
2197:
2190:
2188:
2184:
2179:
2175:
2170:
2165:
2160:
2155:
2151:
2147:
2143:
2136:
2134:
2132:
2128:
2123:
2119:
2115:
2111:
2108:(3): 149–57.
2107:
2103:
2095:
2092:
2087:
2083:
2078:
2073:
2069:
2065:
2061:
2054:
2051:
2046:
2042:
2038:
2034:
2031:(4): 245–55.
2030:
2026:
2019:
2016:
2011:
2007:
2002:
1997:
1993:
1989:
1985:
1981:
1977:
1973:
1969:
1962:
1960:
1958:
1954:
1949:
1945:
1940:
1935:
1931:
1927:
1924:(3): 622–31.
1923:
1919:
1915:
1908:
1905:
1900:
1896:
1891:
1886:
1881:
1876:
1872:
1868:
1864:
1857:
1855:
1851:
1845:
1841:
1837:
1833:
1829:
1825:
1822:(4): 215–21.
1821:
1817:
1810:
1807:
1802:
1798:
1794:
1790:
1786:
1782:
1778:
1774:
1767:
1764:
1758:
1754:
1750:
1746:
1742:
1738:
1734:
1730:
1723:
1720:
1715:
1711:
1707:
1703:
1699:
1695:
1688:
1685:
1680:
1676:
1672:
1668:
1664:
1660:
1657:(2): 132–41.
1656:
1652:
1645:
1642:
1637:
1633:
1629:
1627:0-444-81680-1
1623:
1619:
1612:
1609:
1604:
1600:
1596:
1592:
1585:
1582:
1577:
1573:
1569:
1565:
1562:(1): 144–52.
1561:
1557:
1550:
1547:
1542:
1536:
1534:
1532:
1530:
1526:
1521:
1517:
1513:
1509:
1506:(3): 535–41.
1505:
1501:
1493:
1490:
1485:
1481:
1477:
1473:
1469:
1468:10.1038/15496
1465:
1462:(3): 319–22.
1461:
1457:
1449:
1447:
1443:
1438:
1434:
1428:
1425:
1420:
1416:
1410:
1407:
1403:
1399:
1394:
1392:
1390:
1386:
1382:
1378:
1373:
1371:
1369:
1365:
1359:
1357:
1355:
1351:
1347:
1343:
1338:
1336:
1332:
1327:
1323:
1318:
1315:
1311:
1310:tendon grafts
1307:
1303:
1298:
1295:
1290:
1288:
1285:
1281:
1277:
1273:
1269:
1265:
1261:
1260:camptodactyly
1257:
1253:
1245:
1243:
1239:
1235:
1227:
1223:
1219:
1217:
1212:
1210:
1206:
1202:
1198:
1193:
1189:
1185:
1183:
1178:
1174:
1169:
1167:
1165:
1160:
1156:
1152:
1148:
1144:
1143:somatomedin B
1140:
1136:
1128:
1126:
1122:
1120:
1119:cell adhesion
1116:
1106:
1102:
1100:
1096:
1092:
1088:
1084:
1080:
1076:
1072:
1068:
1064:
1059:
1058:megakaryocyte
1056:
1052:
1048:
1044:
1040:
1032:
1030:
1028:
1024:
1020:
1017:
1013:
1009:
1005:
993:
988:
984:
980:
977:
973:
966:
964:
961:
957:
953:
949:
946:
942:
938:
931:
929:
925:
919:
915:
912:
906:
904:
900:
896:
892:
888:
882:
878:
875:
871:
864:
862:
858:
852:
848:
845:
839:
837:
833:
829:
825:
821:
815:
811:
808:
806:RefSeq (mRNA)
804:
797:
796:
791:
787:
784:
778:
777:
772:
768:
765:
763:
759:
752:
751:
746:
742:
739:
733:
732:
727:
723:
720:
718:
714:
707:
706:
701:
697:
694:
688:
687:
682:
678:
675:
673:
669:
666:
663:
661:
658:
654:
651:
647:
643:
636:
632:
627:
621:
618:
616:
613:
611:
608:
606:
603:
601:
598:
597:
595:
592:
591:
585:
582:
580:
577:
575:
572:
571:
569:
566:
565:
559:
556:
554:
551:
549:
546:
545:
543:
540:
539:
536:
535:Gene ontology
532:
528:
516:
511:
507:
502:
499:
497:
493:
485:
480:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
432:
429:
425:
420:
417:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
370:
367:
363:
358:
355:
354:
351:
349:
345:
343:
342:
338:
337:
334:
332:
328:
324:
320:
316:
308:
303:
299:
295:
290:
280:
276:
269:
262:
256:
249:
241:
237:
233:
228:
224:
219:
215:
207:
202:
198:
194:
189:
179:
175:
168:
161:
155:
148:
144:
138:
134:
130:
125:
121:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
72:
64:
59:
52:
47:
42:
38:
33:
30:
19:
6786:Cerebrolysin
6782:
6756:Pleiotrophin
6712:Interleukins
6625:
6606:
6576:
6495:Fruquintinib
6485:Cabozantinib
6466:
6456:
6414:
6378:Lestaurtinib
6329:
6309:
6277:Lestaurtinib
6228:
6218:
6199:Antagonists:
6198:
6132:Deoxygedunin
6087:3,7,8,2'-THF
6078:
6057:
6048:Against NGF:
6047:
6044:
6000:Against NGF:
5999:
5992:
5989:
5952:Lestaurtinib
5903:
5893:
5887:Testosterone
5869:Antagonists:
5868:
5818:
5718:
5703:
5678:
5659:
5649:
5628:
5618:
5597:
5587:
5566:
5551:
5511:
5426:
5394:
5373:
5364:Against NGF:
5363:
5360:
5316:Against NGF:
5315:
5312:
5306:Testosterone
5288:Antagonists:
5287:
5237:
5207:
5168:
5143:
5132:
5109:Teprotumumab
5070:
5040:
4999:
4948:Ficlatuzumab
4943:Emibetuzumab
4939:
4893:JNJ-38877605
4863:Cabozantinib
4834:
4824:
4813:Fosgonimeton
4808:
4783:
4725:
4703:
4644:
4627:Infigratinib
4623:
4608:
4511:
4428:
4362:Betacellulin
4358:
4341:Seribantumab
4327:
4304:
4263:
4228:
4222:Unknown/none
4221:
4217:
4151:
4076:
4035:Betacellulin
4030:Amphiregulin
4025:
4017:(ErbB1/HER1)
3981:
3953:
3933:
3919:Antagonists:
3918:
3903:
3896:Angiopoietin
3842:
3830:
3778:
3774:
3735:
3731:
3692:
3688:
3649:
3645:
3614:
3610:
3589:
3585:
3540:
3536:
3499:
3495:
3465:(1): 57–66.
3462:
3458:
3433:(4): 730–5.
3430:
3426:
3390:(1): 77–87.
3387:
3383:
3376:
3341:
3337:
3327:
3308:
3304:
3294:
3259:
3255:
3245:
3220:
3216:
3209:
3195:cite journal
3158:
3154:
3144:
3099:
3095:
3085:
3052:
3048:
3042:
3017:
3013:
3007:
2998:
2971:
2967:
2957:
2932:
2928:
2922:
2885:
2881:
2871:
2830:
2826:
2820:
2780:(1): 13149.
2777:
2773:
2763:
2738:
2734:
2728:
2703:
2699:
2693:
2660:
2656:
2650:
2635:
2594:
2590:
2584:
2557:
2553:
2543:
2518:
2514:
2472:
2468:
2462:
2445:
2441:
2435:
2400:
2396:
2386:
2359:
2355:
2305:
2301:
2295:
2287:
2244:
2240:
2230:
2203:
2199:
2149:
2145:
2105:
2101:
2094:
2067:
2063:
2053:
2028:
2024:
2018:
1975:
1971:
1921:
1917:
1907:
1870:
1866:
1819:
1815:
1809:
1776:
1772:
1766:
1735:(3): 562–8.
1732:
1728:
1722:
1697:
1693:
1687:
1654:
1650:
1644:
1617:
1611:
1594:
1590:
1584:
1559:
1555:
1549:
1503:
1499:
1492:
1459:
1455:
1436:
1427:
1418:
1409:
1339:
1319:
1299:
1291:
1272:pericarditis
1249:
1240:
1236:
1232:
1220:
1213:
1197:mucin domain
1181:
1173:glycoprotein
1170:
1163:
1158:
1135:chondrocytes
1132:
1123:
1112:
1036:
1015:
1012:proteoglycan
1007:
1003:
1002:
924:NP_001103616
921:
899:NP_001290161
895:NP_001121182
891:NP_001121181
887:NP_001121180
884:
857:NM_001110146
854:
836:NM_001303232
832:NM_001127710
828:NM_001127709
824:NM_001127708
817:
793:
774:
748:
729:
703:
684:
664:
659:
458:aortic valve
346:
339:
305:150,466,165
292:150,449,412
204:186,314,567
191:186,296,279
66:External IDs
29:
6746:Oncomodulin
6610:Aflibercept
6600:Ranibizumab
6595:Ramucirumab
6585:Bevacizumab
6577:Antibodies:
6535:Regorafenib
6475:Altiratinib
6388:ONO-5390556
6358:Entrectinib
6333:Altiratinib
6287:ONO-5390556
6257:Entrectinib
6232:Altiratinib
6018:Frunevetmab
5990:Antibodies:
5967:ONO-5390556
5932:Entrectinib
5907:Altiratinib
5862:Tavilermide
5757:Quizartinib
5696:SCF (c-Kit)
5520:Ramucirumab
5512:Antibodies:
5485:Quizartinib
5435:Avapritinib
5398:Becaplermin
5334:Frunevetmab
5313:Antibodies:
5216:Trofinetide
5147:Dusigitumab
5144:Antibodies:
5099:Robatumumab
5089:Figitumumab
5084:Dalotuzumab
5079:Cixutumumab
5071:Antibodies:
4963:Rilotumumab
4958:Onartuzumab
4953:Flanvotumab
4940:Antibodies:
4908:PF-04217903
4838:Altiratinib
4801:HGF (c-Met)
4704:Antibodies:
4609:Antibodies:
4331:Duligotumab
4328:Antibodies:
4242:Trastuzumab
4232:Ertumaxomab
4229:Antibodies:
4200:Zalutumumab
4195:Panitumumab
4190:Nimotuzumab
4185:Necitumumab
4175:Imgatuzumab
4152:Antibodies:
4135:Osimertinib
4100:Dacomitinib
3995:Dapiclermin
3954:Antibodies:
3937:Altiratinib
2642:"Biorender"
2403:: 200–206.
1350:recombinant
1346:conjunctiva
1264:arthropathy
1216:vitronectin
1188:sialic acid
1051:homeostasis
1029:lubricant.
620:endocytosis
380:pericardium
284:1|1 G1
44:Identifiers
6802:Categories
6565:Vandetanib
6530:Rebastinib
6525:Pegaptanib
6515:Nintedanib
6505:Lenvatinib
6470:Agerafenib
6423:Ripretinib
6348:CH-7057288
6247:CH-7057288
6112:7,8,3'-THF
6107:7,8,2'-THF
6033:Ranevetmab
6023:Fulranumab
5977:Rebastinib
5922:CH-7057288
5837:Cenegermin
5722:Agerafenib
5682:Agerafenib
5663:Vandetanib
5632:Vandetanib
5601:Vandetanib
5570:Vandetanib
5515:Olaratumab
5490:Ripretinib
5470:Nintedanib
5455:Lenvatinib
5445:Crenolanib
5430:Agerafenib
5349:Ranevetmab
5339:Fulranumab
5256:Cenegermin
5230:LNGF (p75)
5152:Xentuzumab
5114:Xentuzumab
5059:NVP-AEW541
5054:NVP-ADW742
5049:Linsitinib
5044:BMS-754807
5029:Mecasermin
4928:Tivantinib
4918:PHA-665752
4913:PF-2341066
4883:Golvatinib
4873:Crizotinib
4868:Capmatinib
4858:BMS-777607
4853:Amuvatinib
4729:Ersofermin
4692:Sprifermin
4648:Ersofermin
4597:Sprifermin
4587:Repifermin
4582:Palifermin
4515:Ersofermin
4494:Velafermin
4479:Repifermin
4432:Ersofermin
4351:ErbB4/HER4
4336:Patritumab
4297:ErbB3/HER3
4277:Mubritinib
4237:Pertuzumab
4210:ErbB2/HER2
4140:Vandetanib
4095:Canertinib
4090:Brigatinib
4085:Agerafenib
4065:Nepidermin
4060:Murodermin
4050:Epiregulin
4005:EGF (ErbB)
3963:Nesvacumab
3957:Evinacumab
3947:Rebastinib
3888:modulators
3695:(2): 213.
3592:(2): 152.
3382:Disease".
3161:(1): 353.
1404:, May 2017
1383:, May 2017
1360:References
1306:cd-gelatin
1274:syndrome (
1205:Galectin-3
1099:L-selectin
350:(ortholog)
87:HomoloGene
6590:Icrucumab
6570:WHI-P 154
6560:Tivozanib
6555:Toceranib
6550:Sunitinib
6545:Sorafenib
6540:Semaxanib
6520:Pazopanib
6510:Motesanib
6500:Lapatinib
6490:Cediranib
6428:Telbermin
6415:Agonists:
6363:GZ-389988
6343:CE-245677
6310:Agonists:
6262:GZ-389988
6242:CE-245677
6142:Diosmetin
6079:Agonists:
6045:Aptamers:
6038:Tanezumab
6013:Fasinumab
5957:Milciclib
5937:GZ-389988
5917:CE-245677
5819:Agonists:
5772:Toceranib
5767:Sunitinib
5762:Sorafenib
5752:Pazopanib
5747:Nilotinib
5742:Masitinib
5732:Dasatinib
5704:Agonists:
5650:Agonists:
5619:Agonists:
5588:Agonists:
5560:Liatermin
5552:Agonists:
5535:RET (GFL)
5525:Tovetumab
5505:Toceranib
5500:Sorafenib
5495:Sunitinib
5480:Radotinib
5475:Pazopanib
5465:Motesanib
5460:Masitinib
5395:Agonists:
5361:Aptamers:
5354:Tanezumab
5329:Fasinumab
5238:Agonists:
5094:Ganitumab
5014:IGF-1 LR3
4933:Volitinib
4888:INCB28060
4878:Foretinib
4784:Agonists:
4768:Trafermin
4726:Agonists:
4707:Burosumab
4697:Trafermin
4645:Agonists:
4612:Aprutumab
4602:Trafermin
4564:10 (KGF2)
4512:Agonists:
4489:Trafermin
4469:10 (KGF2)
4429:Agonists:
4359:Agonists:
4305:Agonists:
4287:Tucatinib
4282:Neratinib
4272:Lapatinib
4180:Matuzumab
4170:Futuximab
4155:Cetuximab
4145:WHI-P 154
4130:Neratinib
4125:Lapatinib
4115:Grandinin
4110:Gefitinib
4105:Erlotinib
3982:Agonists:
3942:CE-245677
3904:Agonists:
2685:206510494
2247:: 25463.
2102:Hybridoma
2070:: 17–24.
1636:246493326
1335:synovitis
1284:autosomal
1280:arthritis
1268:coxa vara
1211:ability.
1155:hemopexin
1129:Structure
1043:cartilage
928:NP_067375
903:NP_005798
861:NM_021400
820:NM_005807
650:Orthologs
95:GeneCards
6772:instead)
6761:Renalase
6722:instead)
6693:instead)
6640:instead)
6480:Axitinib
6449:D (FIGF)
6393:PLX-7486
6383:ONO-4474
6338:AZD-6918
6292:PLX-7486
6282:ONO-4474
6237:AZD-6918
6219:Ligands:
6137:Deprenyl
6097:7,3'-DHF
6028:MEDI-578
6008:ASP-6294
5972:PLX-7486
5962:ONO-4474
5912:AZD-6918
5872:ALE-0540
5793:instead.
5737:Imatinib
5727:Axitinib
5707:Ancestim
5672:Unsorted
5450:Imatinib
5440:Axitinib
5344:MEDI-578
5324:ASP-6294
5291:ALE-0540
5133:Agonists
5074:AVE-1642
5000:Agonists
4923:SU-11274
4809:Agonists
4787:FGF15/19
4777:Unsorted
4742:2 (bFGF)
4661:2 (bFGF)
4528:2 (bFGF)
4445:2 (bFGF)
4267:Afatinib
4218:Agonists
4120:Icotinib
4080:Afatinib
4026:Agonists
3815:17404241
3754:17343281
3719:21403617
3711:16429407
3676:16335952
3633:16000300
3598:15710563
3577:15302935
3516:14976050
3487:22232515
3479:12783322
3404:27614318
3368:23599181
3286:18512776
3237:22933061
3187:26643105
3136:25933137
3096:PLOS ONE
3077:12089961
3069:22009294
3034:18171967
2990:23046176
2968:Langmuir
2949:24716507
2914:29568558
2855:17093447
2812:29030641
2755:18067335
2735:Langmuir
2677:18239111
2576:16000300
2535:19332105
2497:23192748
2489:12441670
2427:28208081
2378:28373131
2334:32928962
2279:27157803
2178:25187573
2122:11461663
2086:25172828
2010:17142292
1948:15719068
1899:22930755
1844:46582604
1836:16987753
1801:39376563
1793:11124536
1749:15885476
1714:12475643
1671:21966936
1603:10743795
1484:32556762
1476:10545950
1400:–
1379:–
1087:ligament
1067:meniscus
1055:in-vitro
1033:Function
1027:boundary
1008:lubricin
976:Wikidata
629:Sources:
6649:Ephrins
6353:DS-6051
6252:DS-6051
6157:LM22A-4
6147:DMAQ-B1
6102:7,8-DHF
6082:3,7-DHF
6051:RBM-004
5996:GBR-900
5927:DS-6051
5897:VM-902A
5367:RBM-004
5064:OSl-906
5024:Insulin
4903:MK-2461
4848:AMG-458
3985:Axokine
3806:1851076
3783:Bibcode
3762:6804891
3667:1850943
3545:Bibcode
3524:2103324
3449:9550484
3359:3887468
3311:: S32.
3277:2789974
3178:4672561
3127:4416892
3104:Bibcode
2905:5857089
2863:4325718
2835:Bibcode
2803:5640667
2782:Bibcode
2708:Bibcode
2657:Science
2627:1832467
2619:5473985
2599:Bibcode
2405:Bibcode
2325:7681006
2270:4860590
2249:Bibcode
2222:7240180
2169:4256492
2045:1304440
2001:1796837
1980:Bibcode
1890:3476260
1757:1011398
1679:7344867
1576:8185311
1520:9920774
1402:Ensembl
1381:Ensembl
1354:dry eye
1184:-linked
1177:protein
1147:heparin
762:UniProt
717:Ensembl
656:Species
635:QuickGO
442:trachea
325:pattern
83:1891344
51:Aliases
6619:Others
6313:BNN-20
6202:ANA-12
6127:BNN-20
5847:DHEA-S
5832:BNN-27
5827:BNN-20
5266:DHEA-S
5251:BNN-27
5246:BNN-20
5162:Others
4367:Epigen
4045:Epigen
3813:
3803:
3760:
3752:
3717:
3709:
3674:
3664:
3631:
3596:
3575:
3568:514446
3565:
3522:
3514:
3485:
3477:
3447:
3402:
3366:
3356:
3284:
3274:
3235:
3185:
3175:
3134:
3124:
3075:
3067:
3032:
2988:
2947:
2912:
2902:
2861:
2853:
2827:Nature
2810:
2800:
2753:
2683:
2675:
2625:
2617:
2591:Nature
2574:
2533:
2495:
2487:
2425:
2376:
2332:
2322:
2277:
2267:
2220:
2176:
2166:
2120:
2084:
2043:
2008:
1998:
1946:
1939:548698
1936:
1897:
1887:
1842:
1834:
1799:
1791:
1755:
1747:
1712:
1677:
1669:
1634:
1624:
1601:
1574:
1518:
1482:
1474:
1342:cornea
1282:-like
1278:), an
1093:, and
1091:muscle
1063:tendon
962:search
960:PubMed
795:Q9JM99
776:Q92954
672:Entrez
496:BioGPS
183:1q31.1
91:130465
75:604283
6768:(see
6718:(see
6689:(see
6636:(see
6368:K252a
6267:K252a
5942:K252a
5882:FX007
5642:GFRα4
5611:GFRα3
5580:GFRα2
5544:GFRα1
5172:IGFBP
5125:IGF-2
5104:R1507
4992:IGF-1
4898:K252a
4718:FGFR4
4637:FGFR3
4504:FGFR2
4421:FGFR1
3758:S2CID
3715:S2CID
3520:S2CID
3496:Blood
3483:S2CID
3073:S2CID
2888:: 9.
2859:S2CID
2681:S2CID
2623:S2CID
2493:S2CID
1840:S2CID
1797:S2CID
1753:S2CID
1675:S2CID
1480:S2CID
1294:locus
1151:mucin
1115:mucin
1079:heart
1075:liver
1047:joint
1023:joint
1010:is a
705:96875
686:10216
665:Mouse
660:Human
631:Amigo
434:ankle
348:Mouse
341:Human
288:Start
223:Mouse
187:Start
120:Human
6770:here
6720:here
6691:here
6638:here
6433:VEGF
6407:VEGF
6323:NT-3
6318:DHEA
6302:TrkC
6222:DHEA
6192:TDP6
6172:NT-4
6167:NT-3
6152:HIOC
6122:BDNF
6071:TrkB
5842:DHEA
5811:TrkA
5791:here
5789:See
5782:TGFβ
5387:PDGF
5281:NT-4
5276:NT-3
5261:DHEA
5241:BDNF
3990:CNTF
3974:CNTF
3843:PRG4
3831:PRG4
3811:PMID
3750:PMID
3707:PMID
3672:PMID
3629:PMID
3594:PMID
3573:PMID
3512:PMID
3475:PMID
3445:PMID
3400:PMID
3364:PMID
3282:PMID
3233:PMID
3201:link
3183:PMID
3132:PMID
3065:PMID
3030:PMID
2986:PMID
2945:PMID
2910:PMID
2851:PMID
2808:PMID
2751:PMID
2673:PMID
2615:PMID
2572:PMID
2531:PMID
2519:1790
2485:PMID
2423:PMID
2374:PMID
2330:PMID
2275:PMID
2218:PMID
2174:PMID
2118:PMID
2082:PMID
2041:PMID
2006:PMID
1944:PMID
1895:PMID
1832:PMID
1789:PMID
1745:PMID
1710:PMID
1667:PMID
1632:OCLC
1622:ISBN
1599:PMID
1572:PMID
1516:PMID
1472:PMID
1344:and
1324:and
1292:The
1276:CACP
1095:skin
1083:bone
1071:lung
1019:gene
1016:PRG4
331:Bgee
279:Band
240:Chr.
178:Band
137:Chr.
99:PRG4
71:OMIM
58:PRG4
35:PRG4
6187:R13
5857:NGF
5802:Trk
5271:NGF
4983:IGF
4843:AM7
4734:FGF
4653:FGF
4554:),
4552:KGF
4520:FGF
4437:FGF
4412:FGF
4014:EGF
3801:PMC
3791:doi
3779:104
3740:doi
3697:doi
3662:PMC
3654:doi
3619:doi
3615:280
3563:PMC
3553:doi
3541:101
3504:doi
3500:103
3467:doi
3463:443
3435:doi
3392:doi
3354:PMC
3346:doi
3342:131
3313:doi
3272:PMC
3264:doi
3225:doi
3173:PMC
3163:doi
3122:PMC
3112:doi
3057:doi
3053:346
3022:doi
2976:doi
2937:doi
2933:136
2900:PMC
2890:doi
2843:doi
2831:444
2798:PMC
2790:doi
2743:doi
2716:doi
2665:doi
2661:319
2607:doi
2595:228
2562:doi
2558:280
2523:doi
2477:doi
2450:doi
2413:doi
2401:495
2364:doi
2320:PMC
2310:doi
2306:295
2265:PMC
2257:doi
2208:doi
2204:256
2164:PMC
2154:doi
2110:doi
2072:doi
2033:doi
1996:PMC
1988:doi
1934:PMC
1926:doi
1922:115
1885:PMC
1875:doi
1871:287
1824:doi
1781:doi
1737:doi
1702:doi
1659:doi
1564:doi
1560:311
1508:doi
1504:254
1464:doi
1331:ACL
1006:or
301:End
200:End
103:OMA
79:MGI
6804::
6681:B3
6679:,
6677:B2
6675:,
6673:B1
6671:,
6669:A5
6667:,
6665:A4
6663:,
6661:A3
6659:,
6657:A2
6655:,
6653:A1
6447:,
6443:,
6439:,
6182:R7
5998:;
5417:,
5413:,
5409:,
5198:,
5194:,
5190:,
5186:,
5182:,
5178:,
5135::
5002::
4811::
4762:19
4760:,
4756:,
4752:,
4748:,
4744:,
4740:,
4681:23
4679:,
4677:18
4675:,
4671:,
4667:,
4663:,
4659:,
4576:22
4574:,
4572:18
4570:,
4568:17
4566:,
4562:,
4558:,
4546:,
4542:,
4538:,
4534:,
4530:,
4526:,
4473:20
4471:,
4467:,
4463:,
4459:,
4455:,
4451:,
4447:,
4443:,
4395:,
4391:,
4387:,
4383:,
4318:,
4314:,
4220::
4028::
3809:.
3799:.
3789:.
3777:.
3773:.
3756:.
3748:.
3736:25
3734:.
3730:.
3713:.
3705:.
3693:27
3691:.
3687:.
3670:.
3660:.
3648:.
3644:.
3627:.
3613:.
3609:.
3590:90
3588:.
3571:.
3561:.
3551:.
3539:.
3535:.
3518:.
3510:.
3498:.
3481:.
3473:.
3461:.
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