270:. The two distinct lineages of macrophages that Merad defined are represented in tumors, with the different developmental origins dictating their specific roles in shaping the tumor microenvironment. In human lung tumors, Merad's team found that tissue-resident macrophages gather near to tumour cells early in tumour formation and make the tumour cells more invasive, and they also activate a regulatory T cell response that protects the tumour cells from the immune system. During tumor growth, the tissue-resident macrophages move to the periphery and monocyte-derived macrophages dominate the tumor-microenvironment. Other recent key advances from the Merad team in this area include the identification of TREM2 tumor macrophages as immunosuppressive cells that limit natural killer cell recruitment and activity in a murine model of lung adenocarcinoma, the characterization of mature dendritic cells enriched in immunoregulatory molecules (mregDCs) that limit responses to immune checkpoint blockade, and the niches in tumors in which mregDCs operate.
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into new therapeutic approaches. Under Merad's leadership, PrIISM has launched and co-founded with other ISMMS institutes, many programs and centers that support highly productive collaborations between physicians and scientists and enhance synergy between fundamental, translational and clinical research initiatives. These centers and programs include the Human Immune
Monitoring Center, the Microbiome Translational Center, the Center for Inborn Errors of Immunity, the TARGET and INTERACT programs and the Center for Computational Immunology.
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Understanding how different myeloid cell subsets drive distinct inflammatory diseases is one focus of the Merad group's research. In 2021, they identified how mutations in mitogen-activated protein kinase pathway genes trigger sensescence in multipotent human hematopoietic progenitor cells that cause
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and investigates their distinct contributions to health and disease. These studies have revealed the critical contribution of tissue resident macrophages to organ physiology including synaptic pruning, gut peristaltism, fat metabolism and vascular integrity. The Merad laboratory identified a new
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In August 2023, Merad became the founding Chair of the
Department of Immunology and Immunotherapy (DII), a new research department launched at Icahn Mount Sinai that intends to foster a comprehensive understanding of the fundamental biology and profound impact of the immune system on human health and
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in 2007. The institute was renamed the
Precision Immunology Institute (PrIISM) to reflect Merad's vision of transforming the institute to encompass a new, dedicated focus on human immunology and accelerating the translation of research advances made in foundational immunology in preclinical models
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at
Stanford, who provided her with the tools to study the origin of macrophages and dendritic cells. Merad's collaboration with Weissman resulted in a series of ontogeny studies that led to the re-writing of textbook chapters describing the origin of macrophages and dendritic cells. She was first
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disease by skewing progenitor differentiation towards the mononuclear phagocyte lineage. In 2022, they reported that severe COVID19 disease was associated with a reduction in the tissue-resident lung alveolar macrophages that control tissue repair and an increase in inflammatory monocytes and
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in Paris shaped her initial interest in immunotherapy and inspired her move to
Stanford to study dendritic cell-based vaccines with Engleman. Realizing that very little was known about myeloid cell development, Merad collaborated with
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The Merad lab generates detailed transcriptional and epigenetic atlases of dendritic cells and macrophages that are available as resources to uncover new insights into the regulatory networks and molecular identity of these
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Ginhoux, Florent; Greter, Melanie; Leboeuf, Marylene; Nandi, Sayan; See, Peter; Gokhan, Solen; Mehler, Mark F.; Conway, Simon J.; Ng, Lai Guan; Stanley, E. Richard; Samokhvalov, Igor M.; Merad, Miriam (2010).
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recruited to the ISMMS in 2004 and promoted to the rank of associate professor with Tenure in 2007 and to Full
Professor in 2010. She obtained an Endowed Chair in Cancer Immunology in 2014.
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disease. The DII aims to empower researchers to explore groundbreaking scientific inquiries about the immune system and develop innovative types of immunotherapy.
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Miram Merad's early studies were among the first to identify the mechanisms that control the development and functional identity of tissue resident
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1526:"Three Scientists to Receive Top Honors from the Cancer Research Institute for Outstanding Contributions to Cancer Immunology and Immunotherapy"
760:"Three Scientists to Receive Top Honors from the Cancer Research Institute for Outstanding Contributions to Cancer Immunology and Immunotherapy"
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to perform a PhD in the laboratory of Edgar
Engleman. Merad’s clinical training in Hematology / Oncology and bone marrow transplantation in the
1338:"Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma"
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456:"The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting"
1056:"Icahn School of Medicine at Mount Sinai Names Miriam Merad, MD, PhD, as Dean for Translational Research and Therapeutic Innovation"
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can be classified, the importance of immigrants to science in the US and written about her experiences as a mother and a scientist.
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In addition to her research program, Merad has published articles on new approaches to cancer immunotherapy clinical trials, how
1080:"Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes"
499:"Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes"
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subset of dendritic cells, the tissue resident CD103+ DC lineage, that are specialized in anti-viral and anti-tumor immunity.
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1031:"The Tisch Cancer Institute and Precision Immunology Institute at Mount Sinai Launch Center for Computational Immunology"
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The Merad lab has made many discoveries demonstrating the roles that dendritic cells and macrophages play within the
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In April 2024, Merad was named as the new Dean for
Translational Research and Therapeutic Innovation for the
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In 2016, Merad was appointed
Director of the Immunology Institute at ISMMS, which had been founded by
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and the
Director of the Marc and Jennifer Lipschultz Precision Immunology Institute (PrIISM) at the
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241:. In particular, her laboratory established the embryonic origin of tissue resident
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544:"Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment"
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405:"Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages"
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1188:"BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology"
1263:"Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells"
634:"Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells"
362:"Langerhans cells renew in the skin throughout life under steady-state conditions"
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for Distinguished Research in Basic Immunology and a member of the United States
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Department of Immunology and Immunotherapy at the Icahn School of Medicine
1313:"A conserved dendritic-cell regulatory program limits antitumour immunity"
1006:"Finding Common Cause to Advance Immunotherapy Access with Novel Programs"
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Lipschultz Precision Immunology Institute at the Icahn School of Medicine
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1288:"TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer"
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Lavin, Y; Winter, D; Blecher-Gonen, R; David, E; Merad, M (2014).
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Merad, M; Manz, MG; Karsunky, H; Wagers, A; Engleman, EG (2002).
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Ginhoux, F; Greter, M; Leboeuf, M; Nandi, S; Merad, M (2010).
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Merad, M; Sather, P; Helft, J; Miller, J; Mortha, A (2013).
132:(ISMMS) in New York, NY. She is the corecipient of the 2018
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Hashimoto, D; Chow, A; Noizat, C; Teo, P; Merad, M (2013).
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Members of the United States National Academy of Sciences
811:"National Academy of Medicine Elects 100 New Members"
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677:Park, M; Aymeric, S; Ginhoux, F; Merad, M (2023).
1505:"The American Society for Clinical Investigation"
1484:"International Union of Immunological Societies"
1685:Icahn School of Medicine at Mount Sinai faculty
325:for Distinguished Research in Tumor Immunology
310:International Union of Immunological Societies
124:(born 1969) is a French-Algerian professor in
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1700:Members of the National Academy of Medicine
1413:""America First" Will Destroy U.S. Science"
317:American Society for Clinical Investigation
1388:"Pathological sequelae of long-haul COVID"
1238:"Cancer Vaxxer: A Profile of Miriam Merad"
735:"Cancer Vaxxer: A Profile of Miriam Merad"
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110:Icahn School of Medicine at Mount Sinai
1655:21st-century Algerian women scientists
1463:"About the Academy of Immuno-Oncology"
1084:www.sciencedirect.com/journal/immunity
981:"Center for Inborn Errors of Immunity"
223:Ican School of Medicine at Mount Sinai
1438:"Reflections from a mother scientist"
632:Casanova-Acebes, M; Merad, M (2021).
472:10.1146/annurev-immunol-020711-074950
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679:"Macrophages in health and disease"
335:Highly Cited Researcher since 2017
303:Society for Immunotherapy of Cancer
1417:www.sciencedirect.com/journal/cell
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956:"Microbiome Translational Center"
1660:21st-century Algerian scientists
1606:Carnegie Corporation of New York
931:"Human Immune Monitoring Center"
861:"Engleman Trainees 1983-present"
348:Carnegie Corporation of New York
156:from the medical school at the
263:monocyte-derived macrophages.
16:Algerian professor (born 1969)
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260:Langerhans Cell Histiocytosis
516:10.1016/j.immuni.2013.04.004
330:National Academy of Sciences
328:Member of the United States
296:National Academy of Medicine
294:Member of the United States
142:National Academy of Medicine
138:National Academy of Sciences
1532:. Cancer Research Institute
1217:www.science.org/journal/stm
766:. Cancer Research Institute
587:Lavin, Y; Merad, M (2019).
342:In 2020, an honoree of the
305:Academy of Immuno-Oncology.
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1680:Stanford University alumni
1577:"Highly Cited Researchers"
695:10.1016/j.cell.2022.10.007
651:10.1038/s41586-021-03651-8
606:10.1016/j.cell.2017.04.014
561:10.1016/j.cell.2014.11.018
152:Miriam Merad received her
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885:"Irving L. Weissman, MD"
182:Paris Diderot University
170:Paris Diderot University
54:Paris Diderot University
1131:10.1126/science.1194637
836:"miriam-merad, MD, PhD"
429:10.1126/science.1194637
344:Great Immigrants Awards
194:Institut Gustave Roussy
906:"miriam-merad, MD/PhD"
323:William B. Coley Award
268:tumor microenvironment
134:William B. Coley Award
158:University of Algiers
1690:French immunologists
354:Notable publications
172:. After obtaining a
148:Education and career
97:Cancer Immunotherapy
49:Algiers 1 University
1167:www.rupress.org/jem
1123:2010Sci...330..841G
1035:www.mountsinai.org/
1010:www.mountsinai.org/
985:www.mountsinai.org/
960:www.mountsinai.org/
935:www.mountsinai.org/
786:"2020 NAS Election"
421:2010Sci...330..841G
190:HĂ´pital Saint-Louis
186:Stanford University
59:Stanford University
1670:Algerian academics
1581:www.clarivate.com/
1556:www.nasonline.org/
1530:cancerresearch.org
1442:www.nature.com/nm/
1392:www.nature.com/ni/
1367:www.nature.com/nm/
1342:www.nature.com/nm/
1292:www.nature.com/ni/
1192:www.nature.com/nm/
764:cancerresearch.org
1242:the-scientist.com
1117:(6005): 841–845.
790:www.nasonline.org
739:the-scientist.com
689:(23): 4259–4279.
644:(7868): 578–584.
415:(6005): 841–845.
372:(12): 1135–1141.
308:President of the
126:Cancer immunology
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92:Cancer immunology
69:Scientific career
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