169:
129:
38:
320:
Danshiitsoodol N, de Pinho CA, Matoba Y, Kumagai T, Sugiyama M (July 2006). "The mitomycin C (MMC)-binding protein from MMC-producing microorganisms protects from the lethal effect of bleomycin: crystallographic analysis to elucidate the binding mode of the antibiotic to the protein".
123:
catalyzes a ring closure to give 4-amino3-dehydroquinate (aminoDHQ), which then undergoes a double oxidation via aminoDHQ dehydratase to give 4-amino-dehydroshikimate (aminoDHS). The key intermediate, 3-amino-5-hydroxybenzoic acid (AHBA), is made via aromatization by AHBA synthase.
144:, although no specific enzyme has been characterized that mediates this transformation. Once this condensation has occurred, the mitosane core is tailored by a variety of enzymes. Both the sequence and the identity of these steps are yet to be determined.
728:
Majmudar PA, Forstot SL, Dennis RF, Nirankari VS, Damiano RE, Brenart R, Epstein RJ (January 2000). "Topical mitomycin-C for subepithelial fibrosis after refractive corneal surgery".
839:
2599:
1539:
358:"Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564"
100:, to form the mitosane core, followed by specific tailoring steps. The key intermediate, AHBA, is a common precursor to other anticancer drugs, such as
481:
Bleuyard JY, Gallego ME, Savigny F, White CI (February 2005). "Differing requirements for the
Arabidopsis Rad51 paralogs in meiosis and DNA repair".
446:
Schewe MJ, Suzuki DT, Erasmus U (July 1971). "The genetic effects of mitomycin C in
Drosophila melanogaster. II. Induced meiotic recombination".
2515:
832:
213:, mutant strains defective in genes necessary for recombination during meiosis and mitosis are hypersensitive to killing by mitomycin C.
2564:
2122:
2569:
1274:
1230:
1108:
636:
Rustagi T, Aslanian HR, Laine L (2015). "Treatment of
Refractory Gastrointestinal Strictures With Mitomycin C: A Systematic Review".
1033:
296:
151:
Hydroxylation of C-5, C-7 (followed by transamination), and C-9a. – Likely via cytochrome P450 monooxygenase or benzoate hydroxylase
78:
518:"Identification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound collection"
825:
1755:
1549:
148:
Complete reduction of C-6 – Likely via F420-dependent tetrahydromethanopterin (H4MPT) reductase and H4MPT:CoM methyltransferase
2594:
2168:
1170:
1060:
163:
Carbamoylation at C-10 – Carbamoyl transferase, with carbamoyl phosphate (C4P) being derived from L-citrulline or L-arginine
2090:
2073:
1948:
1712:
1090:
201:
is a process of DNA transfer between cells, and is regarded as a form of bacterial sexual interaction. In the fruit fly
1822:
1418:
2532:
2024:
817:
2609:
1204:
222:
81:. Mitomycin C is used as a medicine for treating various disorders associated with the growth and spread of cells.
2390:
2270:
2260:
207:, exposure to mitomycin C increases recombination during meiosis, a key stage of the sexual cycle. In the plant
198:
194:
89:
In general, the biosynthesis of all mitomycins proceeds via combination of 3-amino-5-hydroxybenzoic acid (AHBA),
2442:
2375:
2345:
1963:
1213:
62:
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2427:
2245:
1960:
1446:
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1221:
203:
68:
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2315:
2048:
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181:
1597:
1414:
1384:
1244:
265:
112:
1995:
1872:
1393:
1309:
776:
399:"Antibiotics and UV radiation induce competence for natural transformation in Legionella pneumophila"
254:
230:
209:
57:
765:"Efficacy of mitomycin C in endoscopic dacryocystorhinostomy: a systematic review and meta-analysis"
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2559:
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2180:
2159:
1880:
1702:
1534:
1265:
1161:
225:
108:
97:
30:
This article is about mitomycins as a family of natural products. For its use as a medication, see
1338:
661:
190:
2487:
567:"Borrelia burgdorferi, the Causative Agent of Lyme Disease, Forms Drug-Tolerant Persister Cells"
1368:
1348:
1333:
2574:
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2036:
870:
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115:(E4P) with a yet undiscovered enzyme, which is then ammoniated to give 4-amino-3-deoxy-
741:
374:
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168:
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1603:
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31:
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1048:
1024:
976:
964:
916:
334:
77:. When the name mitomycin occurs alone, it usually refers to mitomycin C, its
306:
137:
The mitosane core is synthesized as shown below via condensation of AHBA and
2497:
2477:
2432:
2422:
2416:
2320:
2265:
2214:
2138:
2128:
2083:
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2011:
1973:
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17:
467:
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2370:
2310:
2078:
2016:
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1692:
1664:
1343:
1180:
681:"Mitomycin C versus 5-Fluorouracil for wound healing in glaucoma surgery"
582:
258:
533:
414:
1299:
1200:
1014:
875:
37:
939:
134:
Synthesis of the key intermediate, 3-amino-5-hydroxy-benzoic acid.
154:
O-Methylation at C-9a – Likely via SAM dependent methyltransferase
36:
679:
Cabourne E, Clarke JC, Schlottmann PG, Evans JR (November 2015).
821:
565:
Sharma B, Brown AV, Matluck NE, Hu LT, Lewis K (August 2015).
397:
Charpentier X, Kay E, Schneider D, Shuman HA (March 2011).
119:-arabino heptulosonic acid-7-phosphate (aminoDHAP). Next,
107:
Specifically, the biosynthesis begins with the addition of
221:
Mitomycin C has been shown to have activity against
160:
Intramolecular amination to form aziridine – Unknown
2207:
2158:
1938:
1931:
1867:
1821:
1754:
1711:
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1413:
1383:
1308:
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1023:
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995:
931:
884:
865:
763:Cheng SM, Feng YF, Xu L, Li Y, Huang JH (2013).
833:
516:Feng J, Shi W, Zhang S, Zhang Y (June 2015).
8:
685:The Cochrane Database of Systematic Reviews
356:Mao Y, Varoglu M, Sherman DH (April 1999).
289:Bacteriophages : methods and protocols
261:surgery, corneal excimer laser surgery and
73:They include mitomycin A, mitomycin B, and
1935:
1545:
1305:
1020:
1003:
881:
840:
826:
818:
798:
788:
704:
590:
541:
422:
373:
276:
571:Antimicrobial Agents and Chemotherapy
7:
638:Journal of Clinical Gastroenterology
2600:Heterocyclic compounds with 4 rings
1109:ribonucleotide reductase inhibitors
1275:Ribonucleotide reductase inhibitor
1231:Ribonucleotide reductase inhibitor
522:Emerging Microbes & Infections
25:
1034:Dihydrofolate reductase inhibitor
157:Oxidation at C-5 and C8 – Unknown
79:international nonproprietary name
495:10.1111/j.1365-313X.2004.02318.x
167:
127:
238:. Mitomycin C is used to treat
1171:Thymidylate synthase inhibitor
1061:Thymidylate synthase inhibitor
697:10.1002/14651858.CD006259.pub2
1:
1091:Adenosine deaminase inhibitor
932:Block microtubule disassembly
742:10.1016/s0161-6420(99)00019-6
375:10.1016/S1074-5521(99)80040-4
790:10.1371/journal.pone.0062737
650:10.1097/MCG.0000000000000295
460:10.1016/0027-5107(71)90015-7
323:Journal of Molecular Biology
250:for its potential to treat
217:Medicinal uses and research
2626:
2565:DNA replication inhibitors
29:
2570:IARC Group 2B carcinogens
2510:
2391:Omacetaxine mepesuccinate
2271:Ciltacabtagene autoleucel
2261:Brexucabtagene autoleucel
335:10.1016/j.jmb.2006.05.017
2443:Talimogene laherparepvec
2376:Nadofaragene firadenovec
2346:Lisocabtagene maraleucel
1295:Topoisomerase inhibitors
1214:DNA polymerase inhibitor
63:Streptomyces caespitosus
2246:Axicabtagene ciloleucel
850:chemotherapeutic agents
403:Journal of Bacteriology
362:Chemistry & Biology
287:, Kropinski AM (2009).
204:Drosophila melanogaster
69:Streptomyces lavendulae
2428:Sitimagene ceradenovec
2326:Idecabtagene vicleucel
1891:Methyl aminolevulinate
199:Natural transformation
182:Legionella pneumophila
45:
41:Chemical structure of
2595:Nitrogen heterocycles
1902:Porphyrin derivatives
1598:Melphalan flufenamide
1245:Hypomethylating agent
854:antineoplastic agents
266:dacryocystorhinostomy
257:, wound healing from
113:erythrose-4-phosphate
40:
2231:Asparagine depleters
2160:Receptor antagonists
2074:+abiraterone acetate
583:10.1128/AAC.00864-15
231:Borrelia burgdorferi
210:Arabidopsis thaliana
27:Group of antibiotics
2281:Denileukin diftitox
2181:Retinoid X receptor
1881:Aminolevulinic acid
1703:Triethylenemelamine
1535:Crosslinking of DNA
1266:Deoxyribonucleotide
1205:+gimeracil/oteracil
781:2013PLoSO...862737C
534:10.1038/emi.2015.31
415:10.1128/JB.01146-10
109:phosphoenolpyruvate
98:carbamoyl phosphate
2537:Never to phase III
1339:Etirinotecan pegol
175:Biological effects
46:
2610:Methoxy compounds
2547:
2546:
2506:
2505:
2463:Tigilanol tiglate
1940:Enzyme inhibitors
1863:
1862:
1859:
1858:
1559:Nitrogen mustards
1529:
1528:
1289:
1288:
991:
990:
617:. Drugs.com. 2017
483:The Plant Journal
448:Mutation Research
248:clinical research
179:In the bacterium
141:
118:
93:
16:(Redirected from
2617:
2468:Tisagenlecleucel
2225:Arsenic trioxide
1936:
1869:Photosensitizers
1660:Alkyl sulfonates
1574:Cyclophosphamide
1546:
1485:Anthracenediones
1306:
1280:Hydroxycarbamide
1021:
1004:
882:
842:
835:
828:
819:
813:
812:
802:
792:
760:
754:
753:
725:
719:
718:
708:
691:(11): CD006259.
676:
670:
669:
633:
627:
626:
624:
622:
611:
605:
604:
594:
577:(8): 4616–4624.
562:
556:
555:
545:
513:
507:
506:
478:
472:
471:
443:
437:
436:
426:
409:(5): 1114–1121.
394:
388:
387:
377:
353:
347:
346:
317:
311:
310:
291:. Humana Press.
281:
252:gastrointestinal
223:stationary phase
171:
139:
131:
116:
91:
58:natural products
52:are a family of
21:
2625:
2624:
2620:
2619:
2618:
2616:
2615:
2614:
2550:
2549:
2548:
2543:
2542:
2527:Clinical trials
2502:
2208:Other/ungrouped
2203:
2154:
1927:
1907:Porfimer sodium
1855:
1817:
1750:
1707:
1537:
1525:
1409:
1379:
1297:
1285:
1260:
1156:
1076:
1012:
1010:antimetabolites
1008:
1007:DNA precursors/
999:
997:DNA replication
987:
927:
897:Vinca alkaloids
873:
861:
846:
816:
762:
761:
757:
727:
726:
722:
678:
677:
673:
644:(10): 837–847.
635:
634:
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608:
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319:
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246:, and is under
219:
177:
104:and ansamycin.
87:
35:
28:
23:
22:
15:
12:
11:
5:
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2177:
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2156:
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2153:
2152:
2146:
2141:
2136:
2131:
2119:
2113:
2108:
2103:
2098:
2087:
2081:
2076:
2068:
2061:PARP inhibitor
2057:
2045:
2033:
2021:
2020:
2019:
2014:
2009:
2004:
1992:
1986:
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1752:
1751:
1749:
1748:
1743:
1738:
1733:
1728:
1723:
1717:
1715:
1713:Platinum-based
1709:
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1706:
1705:
1700:
1695:
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1678:
1677:
1671:
1655:
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1523:
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1513:
1508:
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1497:
1492:
1481:
1475:
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1465:
1460:
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1440:
1435:
1428:Anthracyclines
1423:
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1411:
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1401:
1389:
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1158:
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1155:
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1148:
1146:Mercaptopurine
1137:
1132:
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1116:
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919:
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904:
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890:
879:
863:
862:
848:Intracellular
847:
845:
844:
837:
830:
822:
815:
814:
755:
720:
671:
628:
606:
557:
508:
489:(4): 533–545.
473:
454:(3): 269–279.
438:
389:
368:(4): 251–263.
348:
329:(2): 398–408.
312:
297:
275:
273:
270:
244:stomach cancer
234:, a factor in
218:
215:
195:transformation
176:
173:
165:
164:
161:
158:
155:
152:
149:
86:
83:
60:isolated from
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
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2611:
2608:
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2514:
2513:
2509:
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2409:
2408:
2404:
2402:
2401:Tabelecleucel
2399:
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2387:
2384:
2382:
2379:
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2372:
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2361:Lurbinectedin
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2249:
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2241:
2237:
2233:
2232:
2228:
2226:
2223:
2221:
2218:
2216:
2213:
2212:
2210:
2206:
2199:
2195:
2194:
2190:
2187:
2183:
2182:
2178:
2175:
2171:
2170:
2166:
2165:
2163:
2161:
2157:
2150:
2147:
2145:
2142:
2140:
2137:
2135:
2132:
2130:
2126:
2124:
2120:
2117:
2114:
2112:
2109:
2107:
2104:
2102:
2099:
2097:
2093:
2092:
2088:
2085:
2082:
2080:
2077:
2075:
2072:
2069:
2067:
2063:
2062:
2058:
2055:
2051:
2050:
2046:
2043:
2039:
2038:
2034:
2031:
2027:
2026:
2022:
2018:
2015:
2013:
2010:
2008:
2005:
2003:
2000:
1999:
1998:
1997:
1993:
1990:
1987:
1985:
1982:
1980:
1977:
1975:
1972:
1970:
1966:
1965:
1962:
1958:
1955:
1951:
1950:
1946:
1945:
1943:
1941:
1937:
1934:
1930:
1923:
1920:
1918:
1915:
1913:
1910:
1908:
1904:
1903:
1899:
1897:
1894:
1892:
1889:
1887:
1884:
1882:
1879:
1878:
1876:
1874:
1870:
1866:
1851:
1848:
1846:
1843:
1841:
1838:
1836:
1832:
1829:
1828:
1826:
1824:
1823:Intercalation
1820:
1813:
1810:
1808:
1805:
1803:
1799:
1798:
1794:
1792:
1789:
1787:
1784:
1782:
1779:
1776:
1772:
1771:
1767:
1765:
1762:
1761:
1759:
1757:
1753:
1747:
1744:
1742:
1739:
1737:
1734:
1732:
1731:Dicycloplatin
1729:
1727:
1724:
1722:
1719:
1718:
1716:
1714:
1710:
1704:
1701:
1699:
1696:
1694:
1691:
1689:
1686:
1684:
1680:
1679:
1675:
1672:
1670:
1666:
1663:
1661:
1657:
1656:
1653:
1650:
1648:
1645:
1643:
1640:
1637:
1633:
1630:
1628:
1625:
1623:
1620:
1618:
1614:
1613:
1610:
1607:
1605:
1604:Prednimustine
1602:
1599:
1595:
1592:
1590:
1587:
1584:
1581:
1579:
1575:
1572:
1570:
1567:
1565:
1562:
1560:
1556:
1555:
1553:
1551:
1547:
1544:
1541:
1536:
1532:
1522:
1519:
1517:
1514:
1512:
1509:
1507:
1504:
1501:
1498:
1496:
1493:
1491:
1487:
1486:
1482:
1479:
1476:
1474:
1471:
1469:
1466:
1464:
1461:
1459:
1456:
1454:
1451:
1448:
1444:
1441:
1439:
1436:
1434:
1430:
1429:
1425:
1424:
1422:
1420:
1419:Intercalation
1416:
1412:
1405:
1402:
1400:
1396:
1395:
1391:
1390:
1388:
1386:
1382:
1375:
1372:
1370:
1367:
1365:
1362:
1360:
1357:
1355:
1352:
1350:
1347:
1345:
1342:
1340:
1337:
1335:
1332:
1330:
1327:
1325:
1321:
1320:
1316:
1315:
1313:
1311:
1307:
1304:
1301:
1296:
1292:
1281:
1277:
1276:
1272:
1271:
1269:
1267:
1263:
1256:
1253:
1251:
1247:
1246:
1242:
1241:
1237:
1233:
1232:
1228:
1227:
1223:
1222:+daunorubicin
1220:
1216:
1215:
1211:
1210:
1206:
1202:
1199:
1197:
1194:
1192:
1189:
1187:
1186:Doxifluridine
1184:
1182:
1179:
1177:
1173:
1172:
1168:
1167:
1165:
1163:
1159:
1152:
1149:
1147:
1143:
1142:
1138:
1136:
1135:Rabacfosadine
1133:
1131:
1128:
1125:
1122:
1120:
1117:
1115:
1111:
1110:
1106:
1102:
1101:
1097:
1093:
1092:
1088:
1087:
1085:
1083:
1079:
1072:
1069:
1067:
1063:
1062:
1058:
1055:
1052:
1050:
1047:
1045:
1042:
1040:
1036:
1035:
1031:
1030:
1028:
1026:
1022:
1019:
1016:
1011:
1005:
1002:
998:
994:
983:
979:
978:
974:
971:
968:
966:
963:
961:
958:
956:
953:
951:
948:
946:
942:
941:
937:
936:
934:
930:
923:
920:
918:
915:
913:
910:
908:
905:
903:
899:
898:
894:
893:
891:
888:
883:
880:
877:
872:
868:
864:
859:
855:
851:
843:
838:
836:
831:
829:
824:
823:
820:
810:
806:
801:
796:
791:
786:
782:
778:
775:(5): e62737.
774:
770:
766:
759:
756:
751:
747:
743:
739:
735:
731:
730:Ophthalmology
724:
721:
716:
712:
707:
702:
698:
694:
690:
686:
682:
675:
672:
667:
663:
659:
655:
651:
647:
643:
639:
632:
629:
616:
610:
607:
602:
598:
593:
588:
584:
580:
576:
572:
568:
561:
558:
553:
549:
544:
539:
535:
531:
527:
523:
519:
512:
509:
504:
500:
496:
492:
488:
484:
477:
474:
469:
465:
461:
457:
453:
449:
442:
439:
434:
430:
425:
420:
416:
412:
408:
404:
400:
393:
390:
385:
381:
376:
371:
367:
363:
359:
352:
349:
344:
340:
336:
332:
328:
324:
316:
313:
308:
304:
300:
298:9781603271646
294:
290:
286:
280:
277:
271:
269:
267:
264:
260:
256:
253:
249:
245:
241:
237:
233:
232:
227:
224:
216:
214:
212:
211:
206:
205:
200:
196:
192:
188:
184:
183:
174:
172:
170:
162:
159:
156:
153:
150:
147:
146:
145:
143:
135:
132:
130:
125:
122:
114:
110:
105:
103:
99:
95:
84:
82:
80:
76:
72:
70:
65:
64:
59:
55:
51:
44:
39:
33:
19:
2448:Tazemetostat
2412:Alitretinoin
2405:
2316:Estramustine
2296:Elsamitrucin
2286:Eflornithine
2240:Pegaspargase
2236:Asparaginase
2229:
2198:Testolactone
2191:
2179:
2167:
2121:
2106:Panobinostat
2089:
2059:
2047:
2035:
2023:
1994:
1959:
1947:
1900:
1896:Padeliporfin
1844:
1835:Dactinomycin
1831:Streptomyces
1812:Temozolomide
1807:Mitozolomide
1795:
1786:Mitobronitol
1775:Procarbazine
1768:
1756:Nonclassical
1681:
1658:
1652:Streptozocin
1617:Nitrosoureas
1615:
1589:Chlorambucil
1583:Trofosfamide
1569:Chlormethine
1564:Bendamustine
1557:
1495:Mitoxantrone
1490:Losoxantrone
1483:
1443:Daunorubicin
1426:
1392:
1329:Camptothecin
1317:
1273:
1243:
1229:
1212:
1196:Fluorouracil
1176:Capecitabine
1169:
1139:
1103:
1089:
1059:
1054:Pralatrexate
1044:Methotrexate
1032:
975:
938:
895:
772:
768:
758:
736:(1): 89–94.
733:
729:
723:
688:
684:
674:
641:
637:
631:
619:. Retrieved
609:
574:
570:
560:
525:
521:
511:
486:
482:
476:
451:
447:
441:
406:
402:
392:
365:
361:
351:
326:
322:
315:
288:
279:
236:lyme disease
229:
220:
208:
202:
180:
178:
166:
142:-glucosamine
136:
133:
126:
121:DHQ synthase
106:
94:-glucosamine
88:
85:Biosynthesis
67:
61:
56:-containing
49:
47:
2523:from market
2493:Vorasidenib
2473:Trabectedin
2458:Tiazofurine
2453:Tebentafusp
2438:Tagraxofusp
2396:Plitidepsin
2366:Mitoguazone
2306:Epacadostat
2276:Demecolcine
2220:Aflibercept
2193:Sex steroid
2066:Fuzuloparib
2007:Carfilzomib
1979:Palbociclib
1969:Abemaciclib
1922:Verteporfin
1886:Efaproxiral
1802:Dacarbazine
1764:Altretamine
1746:Satraplatin
1741:Oxaliplatin
1721:Carboplatin
1698:Triaziquone
1669:Mannosulfan
1647:Ranimustine
1627:Fotemustine
1468:Pirarubicin
1453:Doxorubicin
1447:+cytarabine
1433:Aclarubicin
1394:Podophyllum
1319:Camptotheca
1250:Azacitidine
1236:Gemcitabine
1191:Floxuridine
1124:Fludarabine
1119:Clofarabine
1105:Halogenated
1096:Pentostatin
1071:Raltitrexed
1039:Aminopterin
982:Ixabepilone
977:Epothilones
945:Cabazitaxel
922:Vinorelbine
907:Vincristine
902:Vinblastine
887:microtubule
621:11 November
615:"Mitomycin"
187:mitomycin C
75:mitomycin C
43:mitomycin C
32:Mitomycin C
18:Mitomycin-C
2590:Aziridines
2580:Carbamates
2560:Mitomycins
2554:Categories
2488:Verdinexor
2483:Venetoclax
2386:Oblimersen
2381:Navitoclax
2356:Lucanthone
2351:Lonidamine
2341:Lifileucel
2336:Ivosidenib
2331:Imetelstat
2301:Enasidenib
2291:Elesclomol
2256:Bexarotene
2251:Belzutifan
2186:Bexarotene
2174:Atrasentan
2149:Umbralisib
2144:Idelalisib
2134:Copanlisib
2116:Vorinostat
2111:Romidepsin
2101:Entinostat
2096:Belinostat
2054:Masoprocol
2042:Tiazofurin
2030:Anagrelide
2002:Bortezomib
1989:Seliciclib
1984:Ribociclib
1964:inhibitors
1954:Tipifarnib
1917:Temoporfin
1912:Talaporfin
1850:Plicamycin
1845:Mitomycins
1791:Pipobroman
1770:Hydrazines
1736:Nedaplatin
1688:Carboquone
1683:Aziridines
1674:Treosulfan
1622:Carmustine
1609:Uramustine
1578:Ifosfamide
1550:Alkylating
1511:Bisantrene
1500:Pixantrone
1473:Valrubicin
1463:Idarubicin
1458:Epirubicin
1404:Teniposide
1359:Lurtotecan
1354:Irinotecan
1255:Decitabine
1219:Cytarabine
1162:Pyrimidine
1151:Tioguanine
1141:Thiopurine
1130:Nelarabine
1114:Cladribine
1066:Pemetrexed
1049:Pemetrexed
1025:Folic acid
965:Paclitaxel
917:Vinflunine
528:(6): e31.
272:References
263:endoscopic
255:strictures
240:pancreatic
228:caused by
226:persisters
191:competence
50:mitomycins
2533:Phase III
2521:Withdrawn
2498:Vosaroxin
2478:Veliparib
2433:Sotorasib
2423:Selinexor
2417:Tretinoin
2407:Retinoids
2321:Glasdegib
2266:Celecoxib
2215:Adagrasib
2139:Duvelisib
2129:Alpelisib
2084:Rucaparib
2071:Niraparib
2012:Oprozomib
1974:Alvocidib
1840:Bleomycin
1797:Triazenes
1781:Etoglucid
1726:Cisplatin
1642:Nimustine
1636:Semustine
1632:Lomustine
1594:Melphalan
1521:Menogaril
1516:Crisnatol
1506:Amsacrine
1478:Zorubicin
1438:Amrubicin
1399:Etoposide
1374:Topotecan
1369:Silatecan
1364:Rubitecan
1349:Gimatecan
1334:Cositecan
1324:Belotecan
1000:inhibitor
970:Tesetaxel
960:Ortataxel
955:Larotaxel
950:Docetaxel
912:Vindesine
307:297169927
285:Clokie MR
111:(PEP) to
102:rifamycin
54:aziridine
2575:Quinones
2371:Mitotane
2311:Eribulin
2079:Olaparib
2017:Ixazomib
1693:Thiotepa
1665:Busulfan
1344:Exatecan
1181:Carmofur
889:assembly
852: /
809:23675423
769:PLOS ONE
750:10647725
715:26545176
658:25626632
601:26014929
552:26954881
503:15686518
433:21169481
384:10099135
343:16756991
259:glaucoma
189:induces
1300:S phase
1201:Tegafur
1015:S phase
940:Taxanes
876:M phase
800:3652813
777:Bibcode
706:8763343
666:5867992
592:4505243
543:5176177
468:5563942
424:3067580
2605:Enones
2585:Ethers
2516:WHO-EM
2125:(Pi3K)
1082:Purine
885:Block
807:
797:
748:
713:
703:
664:
656:
599:
589:
550:
540:
501:
466:
431:
421:
382:
341:
305:
295:
96:, and
2037:IMPDI
1932:Other
662:S2CID
2123:PIKI
2091:HDAC
1540:CCNS
805:PMID
746:PMID
711:PMID
689:2015
654:PMID
623:2017
597:PMID
548:PMID
499:PMID
464:PMID
429:PMID
380:PMID
339:PMID
303:OCLC
293:ISBN
242:and
193:for
48:The
2169:ERA
2025:PhI
1996:PrI
1961:CDK
1873:PDT
871:MIs
867:SPs
858:L01
795:PMC
785:doi
738:doi
734:107
701:PMC
693:doi
646:doi
587:PMC
579:doi
538:PMC
530:doi
491:doi
456:doi
419:PMC
411:doi
407:193
370:doi
331:doi
327:360
197:.
66:or
2556::
2529::
2049:LI
1949:FI
1415:II
1385:II
1207:))
803:.
793:.
783:.
771:.
767:.
744:.
732:.
709:.
699:.
687:.
683:.
660:.
652:.
642:49
640:.
595:.
585:.
575:59
573:.
569:.
546:.
536:.
524:.
520:.
497:.
487:41
485:.
462:.
452:12
450:.
427:.
417:.
405:.
401:.
378:.
364:.
360:.
337:.
325:.
301:.
268:.
185:,
2419:)
2410:(
2242:)
2238:/
2234:(
2200:)
2196:(
2188:)
2184:(
2176:)
2172:(
2151:)
2127:(
2118:)
2094:(
2086:)
2064:(
2056:)
2052:(
2044:)
2040:(
2032:)
2028:(
1991:)
1967:(
1956:)
1952:(
1924:)
1905:(
1871:/
1852:)
1833:(
1814:)
1800:(
1777:)
1773:(
1685::
1676:)
1667:(
1662::
1638:)
1634:(
1619::
1600:)
1596:(
1585:)
1576:(
1561::
1542:)
1538:(
1502:)
1488:(
1480:)
1449:)
1445:(
1431:(
1417:+
1406:)
1397:(
1376:)
1322:(
1310:I
1302:)
1298:(
1282:)
1278:(
1257:)
1248:(
1238:)
1234:(
1224:)
1217:(
1203:(
1174:(
1153:)
1144:(
1126:)
1112:(
1107:/
1098:)
1094:(
1073:)
1064:(
1056:)
1037:(
1017:)
1013:(
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980:(
972:)
943:(
924:)
900:(
878:)
874:(
869:/
860:)
856:(
841:e
834:t
827:v
811:.
787::
779::
773:8
752:.
740::
717:.
695::
668:.
648::
625:.
603:.
581::
554:.
532::
526:4
505:.
493::
470:.
458::
435:.
413::
386:.
372::
366:6
345:.
333::
309:.
140:D
117:D
92:D
71:.
34:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
