1387:. Some research suggests that certain phenotypes of depression, such as those with anxiety, and "atypical" symptoms involving psychomotor retardation, weight gain and interpersonal sensitivity respond better to MAO inhibitors than other classes of anti-depressant. However the findings related to this have not been consistent. MAOIs may be effective in treatment resistant depression, especially when it does not respond to tricyclic antidepressants.
874:
377:
563:
7192:
2935:
Domschke K, Sheehan K, Lowe N, Kirley A, Mullins C, O'sullivan R, et al. (April 2005). "Association analysis of the monoamine oxidase A and B genes with attention deficit hyperactivity disorder (ADHD) in an Irish sample: preferential transmission of the MAO-A 941G allele to affected children".
864:
Other studies, in which the activities of MAO (not protein amounts) were examined in rat brain, revealed the highest MAO-B activity in the median eminence of hypothalamus. Dorsal raphe nucleus and medial preoptic area have relatively high MAO-B activity, but much lower than MAO-B activity in the
1537:
arousal and rage. This is argued to provide direct support for the idea that genetic susceptibility to disease is not determined at birth, but varies with exposure to environmental influences. However, most individuals with conduct disorder or convictions did not have low activity of MAO-A;
844:
MAO-A appears at roughly 80% of adulthood levels at birth, increasing very slightly after the first 4 years of life, while MAO-B is almost non-detectable in the infant brain. Regional distribution of the monoamine oxidases is characterized by extremely high levels of both MAOs in the
865:
median eminence. Among cerebral endocrine glands, pineal gland has high MAO-B activity (its median value is lower than that for median eminence and higher than that for medial preoptic area). Pituitary has the lowest level of MAO-B activity when compared with brain areas studied.
955:) in the binding pocket that are commonly involved in inhibitor activity have been hypothesized to be relevant to orienting substrates, and mutations of these residues are relevant to mental health. Four main models have been proposed for the mechanism of
1527:
than maltreated children with the high-activity variant. Out of the 442 total males in the study (maltreated or not), 37% had the low activity variant. Of the 13 maltreated males with low MAO-A activity, 11 had been assessed as exhibiting
3022:
Bussone G, Boiardi A, Cerrati A, Girotti F, Merati B, Rivolta G (1 October 2016). "Monoamine oxidase activities in patients with migraine or with cluster headache during the acute phases and after treatment with L-5-hydroxytryptophan".
1572:. This supported earlier studies finding different proportions of variants in different ethnic groups. This is the case for many genetic variants, with 33% White/Non-Hispanic, 61% Asian/Pacific Islanders having the low-activity MAO-A
2499:
Kawamura M, Eisenhofer G, Kopin IJ, Kador PF, Lee YS, Fujisawa S, et al. (March 2002). "Aldose reductase: an aldehyde scavenging enzyme in the intraneuronal metabolism of norepinephrine in human sympathetic ganglia".
1541:
The claim that an interaction between low MAO-A activity and maltreatment would cause anti-social behavior has been criticized since the predisposition towards anti-social behavior could equally well have been caused by
1532:
and 4 were convicted for violent offenses. The suggested mechanism for this effect is the decreased ability of those with low MAO-A activity to quickly degrade norepinephrine, the synaptic neurotransmitter involved in
3849:
Shiraishi H, Suzuki A, Fukasawa T, Aoshima T, Ujiie Y, Ishii G, et al. (April 2006). "Monoamine oxidase A gene promoter polymorphism affects novelty seeking and reward dependence in healthy study participants".
861:, which contains a balance of both. Autopsied brains demonstrated the predicted increased concentration of MAO-A in regions dense in serotonergic neurotransmission, however MAO-B only correlated with norepinephrine.
2899:
Meyer JH, Ginovart N, Boovariwala A, Sagrati S, Hussey D, Garcia A, et al. (November 2006). "Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression".
1327:, MAO dysfunction (too much or too little MAO activity) is thought to contribute to a number of psychiatric and neurological disorders. Unusually high or low levels of MAOs in the body have been associated with
2154:
Kalgutkar AS, Dalvie DK, Castagnoli N, Taylor TJ (September 2001). "Interactions of nitrogen-containing xenobiotics with monoamine oxidase (MAO) isozymes A and B: SAR studies on MAO substrates and inhibitors".
1347:
are one of the major classes of drug prescribed for the treatment of depression, although they are often last-line treatment due to risk of the drug's interaction with diet or other drugs. Excessive levels of
4862:
2017:
Razygraev AV, Taborskaya KI, Volovik KY, Bunina AA, Petrosyan MA (2016-04-01). "Monoamine oxidase activity in the rat pineal gland: Comparison with brain areas and alteration during aging".
2736:
Pang X, Tang C, Guo R, Chen X (May 2022). "Non-cytochrome P450 enzymes involved in the oxidative metabolism of xenobiotics: Focus on the regulation of gene expression and enzyme activity".
5770:
3240:
Kristensson K, Nygård M, Bertini G, Bentivoglio M (June 2010). "African trypanosome infections of the nervous system: parasite entry and effects on sleep and synaptic functions".
2864:
Schildkraut JJ, Herzog JM, Orsulak PJ, Edelman SE, Shein HM, Frazier SH (April 1976). "Reduced platelet monoamine oxidase activity in a subgroup of schizophrenic patients".
1402:- gets its name from the sleep disruption it causes in mammals. That sleep disruption is caused, at least in part, by trypanosomes' tendency to disrupt MAO activity in the
4855:
3128:
1714:
1665:
5281:
4057:
333:
184:
3888:
3050:
Filic V, Vladic A, Stefulj J, Cicin-Sain L, Balija M, Sucic Z, et al. (February 2005). "Monoamine oxidases A and B gene polymorphisms in migraine patients".
277:
265:
5763:
598:
435:
203:
4848:
1584:
Unlike many other enzymes, MAO-B activity is increased during aging in the brain of humans and other mammals. Increased MAO-B activity was also found in the
959:(single electron transfer, hydrogen atom transfer, nucleophilic model, and hydride transfer) although there is insufficient evidence to support any of them.
3425:
dans les conditions normales et après intoxication par deux insecticides: le chlordiméform et la diéldrine" [Monoamine oxidase activity of the brain of
7222:
5318:
3675:
Sloley BD, Bailey BA, Downer RG (1985). "Effects of chlordimeform and lindane on monoamine levels in the central nervous system of the american cockroach,
3773:
Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, et al. (August 2002). "Role of genotype in the cycle of violence in maltreated children".
4538:
3523:
Lund AE, Hollingworth RM, Shankland DL (1979). "Chlordimeform: Plant protection by a sublethal, noncholinergic action on the central nervous system".
5756:
4533:
2371:
Matthes S, Mosienko V, Bashammakh S, Alenina N, Bader M (2010). "Tryptophan hydroxylase as novel target for the treatment of depressive disorders".
4624:
4206:
2698:
Ambroziak W, Maśliński C (April 1988). "Participation of aldehyde dehydrogenase in the oxidative deamination pathway of histamine and putrescine".
2535:
Bandala C, Cárdenas-Rodríguez N, Mendoza-Torreblanca JG, Contreras-García IJ, Martínez-López V, Cruz-Hernández TR, et al. (February 2023).
7161:
6599:
5000:
4292:
757:
3833:
3486:
2355:
2304:
2062:
4101:
1379:
In fact, MAO-A inhibitors act as antidepressant and anti-anxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat
7212:
5274:
4050:
7165:
6910:
5800:
5177:
5143:
5129:
4986:
3283:
Garrick NA, Murphy DL (1980). "Species differences in the deamination of dopamine and other substrates for monoamine oxidase in brain".
622:
459:
4392:
4327:
2774:
Strolin
Benedetti M, Dostert P, Tipton KF. "Contributions of monoamine oxidase to the metabolism of xenobiotics". In Gibson GG (ed.).
2537:"Therapeutic Potential of Dopamine and Related Drugs as Anti-Inflammatories and Antioxidants in Neuronal and Non-Neuronal Pathologies"
2406:
Slominski A, Tobin DJ, Zmijewski MA, Wortsman J, Paus R (January 2008). "Melatonin in the skin: synthesis, metabolism and functions".
5479:
5376:
5314:
4337:
4162:
767:. Because of the latter, they are involved in a number of psychiatric and neurological diseases, some of which can be treated with
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4461:
4096:
3738:
610:
447:
196:
5987:
5965:
5267:
4830:
4658:
4322:
4043:
1080:
939:. Monoamine oxidase A and B share roughly 70% of their structure and both have substrate binding sites that are predominantly
603:
440:
7169:
6880:
6701:
6000:
4653:
4439:
4397:
123:
5635:
353:
147:
3681:
3624:
3525:
1130:
7021:
6649:
5020:
4935:
3571:
Aziz SA, Knowles CO (April 1973). "Inhibition of monoamine oxidase by the pesticide chlordimeform and related compounds".
2829:
Domino EF, Khanna SS (March 1976). "Decreased blood platelet MAO activity in unmedicated chronic schizophrenic patients".
1538:
maltreatment was found to have caused stronger predisposition for antisocial behavior than differences in MAO-A activity.
7182:
5259:
3970:
Nicotra A, Pierucci F, Parvez H, Senatori O (January 2004). "Monoamine oxidase expression during development and aging".
3896:
7141:
5094:
4243:
4185:
4075:
1630:
Tipton KF, Boyce S, O'Sullivan J, Davey GP, Healy J (August 2004). "Monoamine oxidases: certainties and uncertainties".
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768:
397:
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1344:
1150:
1100:
1090:
1046:
976:
932:
917:
889:
389:
2979:
Oreland L (January 2004). "Platelet monoamine oxidase, personality and alcoholism: the rise, fall and resurrection".
6710:
6705:
6390:
6018:
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5956:
5779:
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5302:
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1534:
1336:
1206:
987:
764:
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5710:
5697:
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5671:
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5409:
5354:
5332:
5310:
5215:
4995:
4196:
1679:
Edmondson DE, Mattevi A, Binda C, Li M, Hubálek F (August 2004). "Structure and mechanism of monoamine oxidase".
1060:
814:
5630:
1034:; however, some evidence suggests MAO-B may not be responsible for a significant amount of dopamine degradation.
5584:
5527:
5298:
4387:
4265:
3949:
1308:
1183:
1179:
722:
141:
34:
3375:
Shih JC (January 2004). "Cloning, after cloning, knock-out mice, and physiological functions of MAO A and B".
341:
6953:
5532:
5422:
5327:
5074:
5055:
4915:
4434:
4221:
2621:
Holt A (November 2018). "On the practical aspects of characterising monoamine oxidase inhibition in vitro".
1484:
1414:
There are significant differences in MAO activity in different species. Dopamine is primarily deaminated by
1395:
929:
886:
128:
7111:
3144:"The clinical characterization of the adult patient with depression aimed at personalization of management"
1975:
Razygraev AV, Arutjunyan AV (2007-09-01). "Monoamine oxidase activity in several structures of rat brain".
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7149:
6996:
6830:
6809:
5933:
5124:
4429:
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1384:
1380:
1365:
1229:
1187:
1175:
803:
2078:
Vianello R, Repič M, Mavri J (2012-10-25). "How are
Biogenic Amines Metabolized by Monoamine Oxidases?".
1836:"Monoamine Oxidases (MAOs) as Privileged Molecular Targets in Neuroscience: Research Literature Analysis"
1167:
615:
452:
6714:
5991:
5969:
5553:
5472:
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5243:
5169:
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4543:
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4233:
3122:
1708:
1659:
1070:
882:
208:
7041:
5625:
337:
116:
7227:
7145:
6456:
6446:
5367:
5239:
4981:
4644:
4550:
4407:
4356:
4302:
3979:
3782:
3690:
3633:
3580:
3534:
3384:
2988:
1602:
668:
505:
51:
6584:
6308:
5589:
5446:
5035:
5030:
2663:
Benedetti MS, Dostert P (1994). "Contribution of amine oxidases to the metabolism of xenobiotics".
1925:"Distribution of monoamine oxidase proteins in human brain: implications for brain imaging studies"
1588:
of aging rats. This may contribute to lowered levels of monoamines in aged brain and pineal gland.
1419:
1415:
1332:
1052:
948:
784:
780:
591:
554:
289:
46:
6775:
6372:
6367:
3429:
in normal conditions and after intoxication by two insecticides: chlordimeform and dieldrin].
2192:"Redefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis"
763:
MAOs are important in the breakdown of monoamines ingested in food, and also serve to inactivate
144:
6760:
6741:
6737:
6723:
6719:
6489:
6290:
5942:
5522:
4574:
4342:
4216:
3941:
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3755:
3714:
3657:
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3500:
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3308:
3265:
3075:
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2775:
2034:
1992:
1802:
1573:
1520:
1460:
1373:
1236:
1140:
68:
6629:
3732:
P. Atkinson, K. Binnington, W. J. Roulston (1974). "High monoamine oxidase activity in the tick
2586:
Dalvie D, Di L (September 2019). "Aldehyde oxidase and its role as a drug metabolizing enzyme".
744:, employing oxygen to clip off their amine group. They are found bound to the outer membrane of
7066:
6634:
3421:
Gripois D, Moreteau B, Ramade F (March 1977). "Sur l'activité monoaminoxydasique du cerveau de
1268:
7217:
6926:
6900:
6870:
6678:
6669:
6639:
6230:
6009:
6005:
4564:
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4022:
3995:
3933:
3867:
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3004:
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2568:
2517:
2474:
2423:
2388:
2351:
2320:
2300:
2256:
2239:
Tipton KF (November 2018). "90 years of monoamine oxidase: some progress and some confusion".
2221:
2172:
2136:
2058:
1954:
1905:
1867:
1794:
1759:
1696:
1647:
1232:
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569:
406:
328:
135:
1272:
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6732:
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6494:
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Bortolato M, Godar SC, Alzghoul L, Zhang J, Darling RD, Simpson KL, et al. (May 2013).
3292:
3249:
3212:
3204:
3163:
3155:
3102:
3093:
Riederer P, Lachenmayer L, Laux G (August 2004). "Clinical applications of MAO-inhibitors".
3059:
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2909:
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2707:
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2595:
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2509:
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2454:
2415:
2380:
2343:
2310:
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2126:
2118:
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2026:
1984:
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1936:
1897:
1857:
1847:
1786:
1749:
1741:
1688:
1639:
1529:
1524:
1509:
1470:
1324:
858:
663:
500:
320:
7091:
7056:
6687:
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5983:
5615:
5599:
5512:
5385:
5181:
4940:
4282:
4175:
1430:
1340:
1209:
1106:
857:. The cortex has relatively high levels of only MAO-A, with the exception of areas of the
854:
692:
529:
376:
104:
1569:
1508:, and have about 70% sequence similarity. Rare mutations in the gene are associated with
672:
509:
4840:
3983:
3786:
3694:
3637:
3622:
Beeman RW, Matsumura F (1974). "Studies on the action of chlordimeform in cockroaches".
3584:
3538:
3388:
3142:
Maj M, Stein DJ, Parker G, Zimmerman M, Fava GA, De Hert M, et al. (October 2020).
2992:
2281:"Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence"
873:
849:
and hippocampal uncus, as well as a large amount of MAO-B with very little MAO-A in the
80:
7196:
6683:
6615:
6549:
6499:
6405:
6236:
5974:
5853:
5653:
5594:
5294:
5235:
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3751:
3352:
3327:
3217:
3192:
3168:
3143:
2563:
2536:
2469:
2442:
2315:
2296:
2280:
2216:
2191:
2131:
2106:
1949:
1924:
1923:
Tong J, Meyer JH, Furukawa Y, Boileau I, Chang LJ, Wilson AA, et al. (June 2013).
1885:
1862:
1835:
1754:
1729:
1516:
1434:
1357:
1136:
1086:
1012:
1002:
753:
381:
270:
179:
39:
3991:
3478:
3396:
3000:
2513:
2347:
1790:
562:
159:
7206:
6986:
6432:
6096:
6076:
6041:
5849:
5558:
5517:
5380:
5372:
5196:
5051:
4066:
3702:
3645:
3546:
3269:
3208:
2749:
2599:
1820:
1597:
1455:
1423:
1349:
1328:
1217:
1213:
749:
401:
154:
3945:
3879:
3759:
3718:
3661:
3504:
3450:
3312:
3253:
2965:
2038:
1806:
246:
7011:
6790:
6696:
6574:
6509:
6261:
6241:
6136:
6131:
6121:
6046:
5961:
5507:
5161:
4699:
4674:
4332:
4211:
4124:
3810:
3608:
1996:
1585:
1565:
1505:
1160:
1116:
972:
936:
846:
745:
316:
5748:
3079:
2553:
2338:
Bortolato M, Chen K, Shih JC (2010). "The
Degradation of Serotonin: Role of MAO".
282:
2807:
639:
476:
258:
7051:
6969:
6692:
6619:
6504:
6400:
6251:
6180:
6175:
6170:
6066:
6056:
5952:
5884:
5837:
5731:
5666:
5502:
4962:
2913:
1451:
1399:
1353:
1304:
1300:
1292:
1284:
1256:
1252:
1248:
1225:
1221:
1156:
1096:
1016:
1006:
986:
of monoamines ingested in food. Both MAOs are also vital to the inactivation of
940:
817:
748:
in most cell types of the body. The first such enzyme was discovered in 1928 by
702:
539:
163:
7191:
2207:
1307:
is another possible substrate of MAO, which may contribute to formation of its
7121:
7071:
7006:
7001:
6865:
6846:
6780:
6770:
6579:
6564:
6559:
6514:
6358:
6353:
6348:
6333:
6328:
6323:
6318:
6300:
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6266:
6256:
6200:
6190:
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6165:
6116:
6111:
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6071:
6061:
6051:
6036:
5904:
5874:
5870:
5858:
5782:
5108:
4451:
4113:
3343:
3063:
2676:
2634:
2419:
2252:
2030:
1988:
1296:
1288:
1276:
1264:
1260:
1194:
1066:
1031:
983:
646:
483:
393:
3710:
3653:
3554:
3496:
3106:
2815:
2794:
Zetin M (2013-08-31). "A Clinician's Guide to
Monoamine Oxidase Inhibitors".
1901:
1852:
1692:
1643:
294:
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7037:
6976:
6944:
6930:
6896:
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6815:
6795:
6785:
6589:
6343:
6246:
6226:
6218:
6141:
6106:
6101:
6086:
6081:
6014:
5899:
5889:
5844:
5832:
5705:
5679:
5413:
5116:
5112:
4896:
4892:
4382:
3794:
2459:
1550:
1369:
1244:
1240:
1198:
1171:
1056:
1042:
998:
877:
Norepinephrine degradation. Monoamine oxidase is shown left in the blue box.
796:
741:
737:
733:
4026:
3999:
3871:
3802:
3404:
3361:
3261:
3226:
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2324:
2260:
2225:
2176:
2140:
2091:
1958:
1909:
1871:
1798:
1777:
Slotkin TA (1999). "Mary
Bernheim and the discovery of monoamine oxidase".
1763:
1700:
1651:
1519:
concluded that maltreated children with a low-activity polymorphism in the
3937:
3929:
3600:
3328:"Monoamine oxidase A and A/B knockout mice display autistic-like features"
3304:
3193:"The role of monoamine oxidase inhibitors in current psychiatric practice"
2885:
2877:
2842:
2719:
2684:
1940:
1504:
encoding MAO-A and MAO-B are located side-by-side on the short arm of the
6860:
6665:
6569:
6545:
6519:
6472:
6436:
6396:
6338:
6205:
6031:
5996:
5865:
5823:
5157:
4958:
4954:
4528:
4402:
4035:
3442:
3036:
2949:
2850:
2122:
1888:, Chen K (August 2004). "Regulation of MAO-A and MAO-B gene expression".
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905:
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253:
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2938:
American
Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
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111:
92:
3159:
2384:
2168:
1745:
900:. The imine is then non-enzymatically hydrolyzed to the corresponding
573:
410:
6476:
5816:
5718:
5488:
5358:
4871:
4793:
4788:
4758:
4753:
4633:
4613:
4608:
4598:
4593:
4588:
4583:
3592:
2190:
Cho HU, Kim S, Sim J, Yang S, An H, Nam MH, et al. (July 2021).
1403:
991:
913:
901:
792:
729:
634:
471:
348:
191:
87:
75:
63:
3914:"A functional polymorphism in the monoamine oxidase A gene promoter"
3913:
2769:
2767:
1454:
work by inhibiting them. An MAOI effect is especially important for
752:
in the liver and was named tyramine oxidase. The MAOs belong to the
1312:
6850:
6674:
6195:
5828:
5692:
5337:
4813:
4808:
4798:
4783:
4778:
4773:
4768:
4763:
4748:
4743:
4738:
4733:
4728:
4723:
4718:
4713:
4708:
4504:
4491:
979:
952:
897:
893:
832:
810:
3467:
Evans PD (1980). "Biogenic Amines in the Insect
Nervous System".
5173:
1501:
1323:
Because of the vital role that MAOs play in the inactivation of
1280:
1202:
627:
464:
428:
368:
310:
241:
99:
5752:
5461:
5263:
4844:
4039:
6600:
2494:
2492:
2490:
2488:
921:
6911:
5801:
5457:
2107:"Structures and Mechanism of the Monoamine Oxidase Family"
975:, since they are the target for the action of a number of
3736:
and inhibition by chlordimeform and related pesticides".
1834:
Yeung AW, Georgieva MG, Atanasov AG, Tzvetkov NT (2019).
2658:
2656:
2654:
2652:
6881:
7180:
7022:
6650:
3416:
3414:
1523:
region of the MAO-A gene were more likely to develop
1429:
Mice unable to produce either MAO-A or MAO-B display
3566:
3564:
3332:
2274:
2272:
2270:
1821:"CDD Conserved Protein Domain Family: Amino_oxidase"
7090:
7020:
6952:
6943:
6909:
6879:
6829:
6808:
6648:
6598:
6530:
6528:
6455:
6415:
6389:
5913:
5799:
5792:
5644:
5608:
5577:
5546:
5495:
5431:
5408:
5353:
5309:
5224:
5204:
5191:
5156:
5107:
5083:
5063:
5050:
5009:
4970:
4953:
4924:
4904:
4891:
4882:
4697:
4672:
4642:
4622:
4572:
4563:
4517:
4480:
4448:
4416:
4364:
4355:
4311:
4279:
4252:
4230:
4193:
4184:
4161:
4133:
4110:
4083:
4074:
698:
688:
683:
662:
657:
645:
633:
621:
609:
597:
587:
582:
553:
535:
525:
520:
499:
494:
482:
470:
458:
446:
434:
424:
419:
367:
347:
327:
309:
304:
288:
276:
264:
252:
240:
232:
227:
222:
202:
190:
178:
173:
153:
134:
122:
110:
98:
86:
74:
62:
57:
45:
33:
28:
23:
3518:
3516:
3514:
3431:Comptes Rendus de l'Académie des Sciences, Série D
2731:
2729:
1458:(although one result shows little or no effect in
896:which converts the cofactor into its reduced form
892:oxidizes the substrate yielding the corresponding
885:of monoamines. In the first part of the reaction,
6417:
1730:"Tyramine oxidase: A new enzyme system in liver"
1568:" in the popular press, was over-represented in
6954:
6831:
6605:Tooltip Phenylethanolamine N-methyltransferase
5934:
4015:Advances in Gerontology = Uspekhi Gerontologii
2053:Flower R, Rang HP, Dale MM, Ritter JM (2007).
1343:, migraines, and irregular sexual maturation.
1123:(MHMAL; normetanephrine/metanephrine aldehyde)
1113:(MHMAL; normetanephrine/metanephrine aldehyde)
5764:
5473:
5275:
4856:
4051:
3828:. Cambridge, UK: Cambridge University Press.
3462:
3460:
3127:: CS1 maint: DOI inactive as of April 2024 (
1929:Journal of Cerebral Blood Flow and Metabolism
1713:: CS1 maint: DOI inactive as of April 2024 (
1664:: CS1 maint: DOI inactive as of April 2024 (
1205:are substrates of the MAOs. Examples include
1038:Specific reactions catalyzed by MAO include:
8:
6457:
2789:
2787:
2342:. Vol. 21. Elsevier. pp. 203–218.
1103:(DHMAL; norepinephrine/epinephrine aldehyde)
1093:(DHMAL; norepinephrine/epinephrine aldehyde)
6916:Tooltip Acetylserotonin O-methyltransferase
5806:Tooltip Aromatic L-amino acid decarboxylase
1166:Other endogenous substrates of MAO include
6949:
6826:
6412:
5943:
5924:
5796:
5771:
5757:
5749:
5480:
5466:
5458:
5282:
5268:
5260:
5201:
5060:
4967:
4901:
4888:
4863:
4849:
4841:
4569:
4539:Mitochondrial permeability transition pore
4521:
4361:
4190:
4080:
4058:
4044:
4036:
3912:Sabol SZ, Hu S, Hamer D (September 1998).
2105:Gaweska H, Fitzpatrick PF (October 2011).
1549:A possible link between predisposition to
982:. MAO-A is particularly important in the
680:
561:
517:
375:
301:
170:
5915:
3351:
3216:
3167:
2562:
2552:
2468:
2458:
2441:Meiser J, Weindl D, Hiller K (May 2013).
2314:
2215:
2130:
1948:
1861:
1851:
1753:
1437:display an increased response to stress.
4534:Mitochondrial membrane transport protein
4013:Razygraev AV, Arutiunian AV (2008). "".
3889:"The disorder of these times, neophilia"
2287:. International Review of Neurobiology.
872:
771:(MAOIs) which block the action of MAOs.
7187:
7092:
3191:Fiedorowicz JG, Swartz KL (July 2004).
1622:
758:flavin-containing amine oxidoreductases
6886:Tooltip Serotonin N-acetyl transferase
5001:Phenylethanolamine N-methyltransferase
4293:Cholesterol side-chain cleavage enzyme
3120:
3025:Rivista di Patologia Nervosa e Mentale
1706:
1657:
1546:genes inherited from abusive parents.
779:In humans there are two types of MAO:
550:
396:bound, oriented as if attached to the
364:
219:
20:
7027:Tooltip Histamine N-methyltransferase
6655:Tooltip Catechol-O-methyl transferase
3682:Pesticide Biochemistry and Physiology
3625:Pesticide Biochemistry and Physiology
3526:Pesticide Biochemistry and Physiology
2080:European Journal of Organic Chemistry
2012:
2010:
2008:
2006:
1450:Insect brains express MAOs, and some
1131:3-methoxy-4-hydroxyphenylacetaldehyde
1049:(5-HIAL; 5-HIAAL; serotonin aldehyde)
7:
3052:Journal of the Neurological Sciences
2057:. Edinburgh: Churchill Livingstone.
1970:
1968:
567:Ribbon diagram of human MAO-B. From
6535:Tooltip Dopamine beta-monooxygenase
5144:Acetylserotonin O-methyltransferase
4207:Coenzyme Q – cytochrome c reductase
2443:"Complexity of dopamine metabolism"
2340:Handbook of Behavioral Neuroscience
1840:Frontiers in Molecular Neuroscience
990:, for which they display different
7223:Single-pass transmembrane proteins
4393:Oxoglutarate dehydrogenase complex
4328:Glycerol-3-phosphate dehydrogenase
3864:10.1097/01.ypg.0000199447.62044.ef
3752:10.1111/j.1440-6055.1974.tb02174.x
3473:. Vol. 15. pp. 317–473.
2866:The American Journal of Psychiatry
2831:The American Journal of Psychiatry
2297:10.1016/B978-0-12-386467-3.00002-9
1557:of the MAO-A gene has been found.
1482:MAO activity has been detected in
967:Monoamine oxidases are well known
14:
6422:Tooltip Phenylalanine hydroxylase
4338:Carnitine palmitoyltransferase II
2780:. Vol. 11. pp. 149–174.
1121:3-methoxy-4-hydroxymandelaldehyde
1111:3-methoxy-4-hydroxymandelaldehyde
7190:
5139:Aralkylamine N-acetyltransferase
4462:Carbamoyl phosphate synthetase I
4102:Long-chain-fatty-acid—CoA ligase
4097:Carnitine palmitoyltransferase I
3739:Australian Journal of Entomology
3209:10.1097/00131746-200407000-00005
2750:10.1016/j.pharmthera.2021.108020
2600:10.1016/j.pharmthera.2019.05.011
1488:and chlordimeform is an MAOI in
1019:are mainly broken down by MAO-B.
1009:are mainly broken down by MAO-A.
881:Monoamine oxidases catalyze the
775:Subtypes and tissue distribution
6959:Tooltip Histidine decarboxylase
4323:Glutamate aspartate transporter
3952:from the original on 2021-04-04
3254:10.1016/j.pneurobio.2009.12.001
3197:Journal of Psychiatric Practice
2157:Chemical Research in Toxicology
1081:3,4-dihydroxyphenylacetaldehyde
916:is used to restore the reduced
6836:Tooltip Tryptophan hydroxylase
6616:Norepinephrine (noradrenaline)
6550:Norepinephrine (Noradrenaline)
5975:Norepinephrine (noradrenaline)
5939:Tooltip Aldehyde dehydrogenase
4440:Pyruvate dehydrogenase complex
4398:Succinyl coenzyme A synthetase
3887:Heidi Dawley (June 18, 2006).
2902:Archives of General Psychiatry
2055:Rang & Dale's pharmacology
1:
7162:Monoamine reuptake inhibitors
7142:Receptor/signaling modulators
5021:Catechol-O-methyl transferase
4936:Histamine N-methyltransferase
3992:10.1016/S0161-813X(03)00095-0
3479:10.1016/s0065-2806(08)60143-5
3470:Advances in Insect Physiology
3397:10.1016/s0161-813x(03)00112-8
3001:10.1016/S0161-813X(03)00115-3
2554:10.3390/pharmaceutics15020693
2514:10.1016/s1566-0702(01)00385-x
2348:10.1016/s1569-7339(10)70079-5
2279:Bortolato M, Shih JC (2011).
1791:10.1016/S0361-9230(99)00110-0
1468:may or may not be an MAOI in
935:and are, thus, classified as
928:contain the covalently bound
305:Available protein structures:
6462:Tooltip Tyrosine hydroxylase
5095:4-aminobutyrate transaminase
4244:Dihydroorotate dehydrogenase
3826:Making sense of heritability
3703:10.1016/0048-3575(85)90131-2
3646:10.1016/0048-3575(74)90115-1
3547:10.1016/0048-3575(79)90052-x
2808:10.2174/15734005113096660013
1525:antisocial conduct disorders
1345:Monoamine oxidase inhibitors
1186:(GABAL) and by extension of
963:Substrates and specificities
920:cofactor back to the active
769:monoamine oxidase inhibitors
7213:Genes on human chromosome X
7122:Pimagedine (aminoguanidine)
6992:Alpha-Fluoromethylhistidine
4298:Steroid 11-beta-hydroxylase
3095:Current Medicinal Chemistry
2914:10.1001/archpsyc.63.11.1209
2777:Progress in Drug Metabolism
1890:Current Medicinal Chemistry
1681:Current Medicinal Chemistry
1632:Current Medicinal Chemistry
1612:Monoamine oxidase inhibitor
1530:adolescent conduct disorder
1259:, and other compounds like
1151:4-hydroxyphenylacetaldehyde
1101:3,4-dihydroxymandelaldehyde
1091:3,4-dihydroxymandelaldehyde
1073:(IAAL; tryptamine aldehyde)
1061:5-methoxyindoleacetaldehyde
1047:5-hydroxyindoleacetaldehyde
988:monoamine neurotransmitters
977:monoamine oxidase inhibitor
809:MAO-A is also found in the
765:monoamine neurotransmitters
7244:
7166:Monoamine releasing agents
5932:Substrates→Products (with
5442:D-amino acid dehydrogenase
5345:Glutamate synthase (NADPH)
5303:amino acid oxidoreductases
4472:N-Acetylglutamate synthase
4467:Ornithine transcarbamylase
4271:Glycerol phosphate shuttle
4137:monoamine neurotransmitter
2796:Current Psychiatry Reviews
2208:10.1038/s12276-021-00646-3
1368:, and excessive levels of
1337:attention deficit disorder
1207:substituted phenethylamine
1184:γ-acetylaminobutyraldehyde
1083:(DOPAL; dopamine aldehyde)
947:residues (398, 435 within
7134:
6280:
6155:
5927:
5920:Tooltip Monoamine oxidase
5636:Michaelis–Menten kinetics
5216:Choline acetyltransferase
5134:-amino acid decarboxylase
4996:Dopamine beta-hydroxylase
4991:-amino acid decarboxylase
4826:
4524:
4500:
4197:oxidative phosphorylation
3344:10.1017/S1461145712000715
3064:10.1016/j.jns.2004.11.045
2677:10.3109/03602539408998316
2635:10.1007/s00702-018-1943-8
2420:10.1016/j.tem.2007.10.007
2253:10.1007/s00702-018-1881-5
2031:10.1134/S2079057016020120
1989:10.1134/S1819712407030051
1560:A particular variant (or
831:MAO-B is mostly found in
679:
560:
516:
374:
300:
169:
6620:Epinephrine (adrenaline)
5953:Epinephrine (adrenaline)
5528:Diffusion-limited enzyme
4388:Isocitrate dehydrogenase
4266:Malate-aspartate shuttle
3242:Progress in Neurobiology
3107:10.2174/0929867043364775
2623:J Neural Transm (Vienna)
2241:J Neural Transm (Vienna)
1902:10.2174/0929867043364757
1853:10.3389/fnmol.2019.00143
1693:10.2174/0929867043364784
1644:10.2174/0929867043364810
1197:compounds, a variety of
7097:Tooltip Diamine oxidase
5423:Glycine cleavage system
5328:Glutamate dehydrogenase
5075:Glutamate decarboxylase
4916:Histidine decarboxylase
4435:Glutamate dehydrogenase
4222:Succinate dehydrogenase
3795:10.1126/science.1072290
3109:(inactive 2024-04-05).
2460:10.1186/1478-811X-11-34
2408:Trends Endocrinol Metab
2019:Advances in Gerontology
1779:Brain Research Bulletin
1734:The Biochemical Journal
1695:(inactive 2024-04-05).
1646:(inactive 2024-04-05).
1485:Rhipicephalus microplus
6997:Histidine methyl ester
5125:Tryptophan hydroxylase
4831:mitochondrial diseases
4430:Aspartate transaminase
4087:fatty acid degradation
2092:10.1002/ejoc.201201122
1230:substituted tryptamine
1022:Both forms metabolize
951:, 407 and 444 within
878:
822:gastrointestinal tract
804:central nervous system
7170:Monoamine neurotoxins
7112:Imidazole acetic acid
5621:Eadie–Hofstee diagram
5554:Allosteric regulation
5244:Butyrylcholinesterase
5170:Nitric oxide synthase
4544:Mitochondrial carrier
4420:anaplerotic reactions
4256:mitochondrial shuttle
4234:pyrimidine metabolism
3930:10.1007/s004390050816
3677:Periplaneta americana
2878:10.1176/ajp.133.4.438
2843:10.1176/ajp.133.3.323
2111:Biomolecular Concepts
1977:Neurochemical Journal
1941:10.1038/jcbfm.2013.19
1515:A study based on the
1461:Periplaneta americana
1391:Parasite interactions
1319:Clinical significance
883:oxidative deamination
876:
388:of human MAO-A, with
7105:Substrates→Products:
7035:Substrates→Products:
6967:Substrates→Products:
6924:Substrates→Products:
6894:Substrates→Products:
6844:Substrates→Products:
6663:Substrates→Products:
6613:Substrates→Products:
6543:Substrates→Products:
6470:Substrates→Products:
6447:3,4-Dihydroxystyrene
6430:Substrates→Products:
5814:Substrates→Products:
5631:Lineweaver–Burk plot
5368:D-amino acid oxidase
5240:Acetylcholinesterase
4982:Tyrosine hydroxylase
4551:Translocator protein
4408:Malate dehydrogenase
4303:Aldosterone synthase
3852:Psychiatric Genetics
2950:10.1002/ajmg.b.30158
2123:10.1515/BMC.2011.030
1176:monoacetylputrescine
6585:Phenopicolinic acid
6309:Desmethylselegiline
5447:Amine dehydrogenase
4163:Intermembrane space
3984:2004NeuTx..25..155N
3824:Sesardic N (2005).
3787:2002Sci...297..851C
3734:Boophilus Microplus
3695:1985PBioP..24..213S
3638:1974PBioP...4..325B
3585:1973Natur.242..417A
3539:1979PBioP..11..117L
3389:2004NeuTx..25...21S
2993:2004NeuTx..25...79O
1385:Parkinson's disease
1381:Alzheimer's disease
1366:hypertensive crisis
1233:serotonergic agents
1188:γ-aminobutyric acid
1168:telemethylhistamine
1053:5-Methoxytryptamine
555:monoamine oxidase B
369:monoamine oxidase A
6761:2-Hydroxyestradiol
6742:4-Methoxyestradiol
6738:4-Hydroxyestradiol
6724:2-Methoxyestradiol
6720:2-Hydroxyestradiol
6490:2-Hydroxyestradiol
5590:Enzyme superfamily
5523:Enzyme promiscuity
4518:Other/to be sorted
4483:alcohol metabolism
4343:Uncoupling protein
4217:NADH dehydrogenase
3427:Locusta migratoria
3423:Locusta migratoria
3297:10.1007/bf00433804
3285:Psychopharmacology
2712:10.1007/BF02142573
2447:Cell Commun Signal
1471:Locusta migratoria
1374:serotonin syndrome
1237:dimethyltryptamine
1170:, a metabolite of
1141:phenylacetaldehyde
1071:indoleacetaldehyde
879:
815:pulmonary vascular
791:Both are found in
728:) are a family of
715:Monoamine oxidases
7178:
7177:
7173:
7130:
7129:
7042:N-Methylhistamine
6972:
6939:
6938:
6927:N-Acetylserotonin
6901:N-Acetylserotonin
6871:Telotristat ethyl
6866:Fenclonine (PCPA)
6823:
6804:
6803:
6679:Homovanillic acid
6670:3-Methoxytyramine
6479:
6409:
6385:
6384:
6381:
6380:
6362:
6303:
6231:tetrahydroharmine
6211:Harmala alkaloids
6006:3-Methoxytyramine
5861:
5840:
5819:
5746:
5745:
5455:
5454:
5435:: other acceptors
5395:Flavin-containing
5377:Copper-containing
5301:1.4) - primarily
5257:
5256:
5253:
5252:
5152:
5151:
5133:
5103:
5102:
5046:
5045:
5026:Monoamine oxidase
4990:
4949:
4948:
4876:neurotransmission
4838:
4837:
4822:
4821:
4565:Mitochondrial DNA
4559:
4558:
4513:
4512:
4368:citric acid cycle
4351:
4350:
4157:
4156:
4149:Monoamine oxidase
3835:978-0-521-82818-5
3488:978-0-12-024215-3
3160:10.1002/wps.20771
2629:(11): 1685–1705.
2385:10.1159/000279322
2357:978-0-12-374634-4
2306:978-0-12-386467-3
2285:Int Rev Neurobiol
2247:(11): 1519–1551.
2169:10.1021/tx010073b
2086:(36): 7057–7065.
2064:978-0-443-06911-6
1896:(15): 1995–2005.
1746:10.1042/bj0220968
1396:Sleeping sickness
1325:neurotransmitters
1127:3-Methoxytyramine
1063:(5-MIAL; 5-MIAAL)
957:electron transfer
712:
711:
708:
707:
549:
548:
545:
544:
363:
362:
359:
358:
354:structure summary
223:Monoamine oxidase
218:
217:
214:
213:
117:metabolic pathway
24:Monoamine oxidase
16:Family of enzymes
7235:
7195:
7194:
7186:
7136:
7098:
7094:
7028:
7024:
6970:
6960:
6956:
6950:
6917:
6913:
6887:
6883:
6837:
6833:
6827:
6813:
6766:2-Hydroxyestrone
6751:4-Methoxyestrone
6747:4-Hydroxyestrone
6733:2-Methoxyestrone
6729:2-Hydroxyestrone
6656:
6652:
6606:
6602:
6536:
6532:
6495:2-Hydroxyestrone
6480:-DOPA (levodopa)
6477:
6463:
6459:
6423:
6419:
6413:
6394:
6360:
6301:
6288:MAO-B selective:
6163:MAO-A-selective:
6127:Phenoxypropazine
5949:
5945:
5940:
5936:
5925:
5921:
5917:
5859:
5838:
5820:-DOPA (levodopa)
5817:
5807:
5803:
5797:
5773:
5766:
5759:
5750:
5626:Hanes–Woolf plot
5569:Enzyme activator
5564:Enzyme inhibitor
5538:Enzyme catalysis
5482:
5475:
5468:
5459:
5284:
5277:
5270:
5261:
5229:
5209:
5202:
5131:
5088:
5068:
5061:
5014:
4988:
4975:
4968:
4929:
4909:
4902:
4889:
4865:
4858:
4851:
4842:
4702:
4677:
4647:
4627:
4577:
4570:
4522:
4485:
4455:
4423:
4378:Citrate synthase
4371:
4362:
4316:
4286:
4259:
4237:
4200:
4191:
4171:Adenylate kinase
4142:
4118:
4090:
4081:
4060:
4053:
4046:
4037:
4031:
4030:
4010:
4004:
4003:
3967:
3961:
3960:
3958:
3957:
3909:
3903:
3900:
3895:. Archived from
3883:
3846:
3840:
3839:
3821:
3815:
3814:
3770:
3764:
3763:
3729:
3723:
3722:
3672:
3666:
3665:
3619:
3613:
3612:
3593:10.1038/242417a0
3568:
3559:
3558:
3533:(1–3): 117–128.
3520:
3509:
3508:
3464:
3455:
3454:
3418:
3409:
3408:
3372:
3366:
3365:
3355:
3323:
3317:
3316:
3280:
3274:
3273:
3237:
3231:
3230:
3220:
3188:
3182:
3181:
3171:
3148:World Psychiatry
3139:
3133:
3132:
3126:
3118:
3090:
3084:
3083:
3047:
3041:
3040:
3019:
3013:
3012:
2976:
2970:
2969:
2932:
2926:
2925:
2896:
2890:
2889:
2861:
2855:
2854:
2826:
2820:
2819:
2791:
2782:
2781:
2771:
2762:
2761:
2733:
2724:
2723:
2706:(3–4): 311–313.
2695:
2689:
2688:
2660:
2647:
2646:
2618:
2612:
2611:
2583:
2577:
2576:
2566:
2556:
2532:
2526:
2525:
2496:
2483:
2482:
2472:
2462:
2438:
2432:
2431:
2403:
2397:
2396:
2368:
2362:
2361:
2335:
2329:
2328:
2318:
2276:
2265:
2264:
2236:
2230:
2229:
2219:
2202:(7): 1148–1158.
2187:
2181:
2180:
2151:
2145:
2144:
2134:
2102:
2096:
2095:
2075:
2069:
2068:
2051:Figure 11-4 in:
2049:
2043:
2042:
2014:
2001:
2000:
1972:
1963:
1962:
1952:
1920:
1914:
1913:
1882:
1876:
1875:
1865:
1855:
1831:
1825:
1824:
1817:
1811:
1810:
1774:
1768:
1767:
1757:
1728:Hare ML (1928).
1725:
1719:
1718:
1712:
1704:
1676:
1670:
1669:
1663:
1655:
1627:
1510:Brunner syndrome
1418:in rats, but by
1364:) may lead to a
1303:, among others.
1210:sympathomimetics
924:form. Monoamine
859:cingulate cortex
681:
576:
565:
551:
518:
413:
379:
365:
302:
220:
171:
21:
7243:
7242:
7238:
7237:
7236:
7234:
7233:
7232:
7203:
7202:
7201:
7189:
7181:
7179:
7174:
7126:
7096:
7086:
7057:Diphenhydramine
7026:
7016:
6958:
6935:
6915:
6905:
6885:
6875:
6835:
6812:
6800:
6688:Normetanephrine
6654:
6644:
6604:
6594:
6534:
6524:
6461:
6451:
6421:
6404:
6393:
6391:Phenethylamines
6377:
6276:
6151:
6147:Tranylcypromine
5984:Normetanephrine
5947:
5938:
5919:
5909:
5805:
5788:
5777:
5747:
5742:
5654:Oxidoreductases
5640:
5616:Enzyme kinetics
5604:
5600:List of enzymes
5573:
5542:
5513:Catalytic triad
5491:
5486:
5456:
5451:
5427:
5404:
5349:
5305:
5295:oxidoreductases
5293:
5288:
5258:
5249:
5225:
5220:
5205:
5187:
5148:
5099:
5084:
5079:
5064:
5042:
5010:
5005:
4971:
4945:
4941:Diamine oxidase
4925:
4920:
4905:
4878:
4869:
4839:
4834:
4818:
4698:
4693:
4673:
4668:
4643:
4638:
4623:
4618:
4573:
4555:
4509:
4496:
4481:
4476:
4449:
4444:
4417:
4412:
4365:
4347:
4312:
4307:
4283:steroidogenesis
4280:
4275:
4253:
4248:
4231:
4226:
4194:
4180:
4176:Creatine kinase
4153:
4139:
4134:
4129:
4111:
4106:
4084:
4070:
4064:
4034:
4012:
4011:
4007:
3978:(1–2): 155–65.
3972:Neurotoxicology
3969:
3968:
3964:
3955:
3953:
3911:
3910:
3906:
3886:
3848:
3847:
3843:
3836:
3823:
3822:
3818:
3781:(5582): 851–4.
3772:
3771:
3767:
3731:
3730:
3726:
3674:
3673:
3669:
3621:
3620:
3616:
3579:(5397): 417–8.
3570:
3569:
3562:
3522:
3521:
3512:
3489:
3466:
3465:
3458:
3437:(12): 1079–82.
3420:
3419:
3412:
3377:Neurotoxicology
3374:
3373:
3369:
3325:
3324:
3320:
3282:
3281:
3277:
3239:
3238:
3234:
3190:
3189:
3185:
3141:
3140:
3136:
3119:
3101:(15): 2033–43.
3092:
3091:
3087:
3049:
3048:
3044:
3021:
3020:
3016:
2981:Neurotoxicology
2978:
2977:
2973:
2934:
2933:
2929:
2908:(11): 1209–16.
2898:
2897:
2893:
2863:
2862:
2858:
2828:
2827:
2823:
2793:
2792:
2785:
2773:
2772:
2765:
2735:
2734:
2727:
2697:
2696:
2692:
2662:
2661:
2650:
2620:
2619:
2615:
2585:
2584:
2580:
2534:
2533:
2529:
2498:
2497:
2486:
2440:
2439:
2435:
2405:
2404:
2400:
2370:
2369:
2365:
2358:
2337:
2336:
2332:
2307:
2278:
2277:
2268:
2238:
2237:
2233:
2189:
2188:
2184:
2153:
2152:
2148:
2104:
2103:
2099:
2077:
2076:
2072:
2065:
2052:
2050:
2046:
2016:
2015:
2004:
1974:
1973:
1966:
1922:
1921:
1917:
1884:
1883:
1879:
1833:
1832:
1828:
1819:
1818:
1814:
1776:
1775:
1771:
1727:
1726:
1722:
1705:
1687:(15): 1983–93.
1678:
1677:
1673:
1656:
1638:(15): 1965–82.
1629:
1628:
1624:
1620:
1606:
1594:
1582:
1551:novelty seeking
1498:
1480:
1448:
1443:
1412:
1393:
1341:substance abuse
1321:
1107:Normetanephrine
1059:metabolite) to
965:
871:
855:globus pallidus
777:
578:
568:
415:
405:
266:OPM superfamily
17:
12:
11:
5:
7241:
7239:
7231:
7230:
7225:
7220:
7215:
7205:
7204:
7200:
7199:
7176:
7175:
7135:
7132:
7131:
7128:
7127:
7125:
7124:
7115:
7114:
7101:
7099:
7088:
7087:
7085:
7084:
7079:
7074:
7069:
7064:
7059:
7054:
7045:
7044:
7031:
7029:
7018:
7017:
7015:
7014:
7009:
7004:
6999:
6994:
6989:
6980:
6979:
6963:
6961:
6947:
6941:
6940:
6937:
6936:
6934:
6933:
6920:
6918:
6907:
6906:
6904:
6903:
6890:
6888:
6877:
6876:
6874:
6873:
6868:
6863:
6854:
6853:
6840:
6838:
6824:
6806:
6805:
6802:
6801:
6799:
6798:
6793:
6788:
6783:
6778:
6773:
6768:
6763:
6754:
6753:
6744:
6735:
6726:
6717:
6708:
6699:
6690:
6684:Norepinephrine
6681:
6672:
6659:
6657:
6646:
6645:
6643:
6642:
6637:
6632:
6623:
6622:
6609:
6607:
6596:
6595:
6593:
6592:
6587:
6582:
6577:
6572:
6567:
6562:
6553:
6552:
6539:
6537:
6526:
6525:
6523:
6522:
6517:
6512:
6507:
6502:
6500:3-Iodotyrosine
6497:
6492:
6483:
6482:
6466:
6464:
6453:
6452:
6450:
6449:
6440:
6439:
6426:
6424:
6410:
6406:norepinephrine
6387:
6386:
6383:
6382:
6379:
6378:
6376:
6375:
6370:
6365:
6356:
6351:
6346:
6341:
6336:
6331:
6326:
6321:
6316:
6311:
6306:
6298:
6293:
6281:
6278:
6277:
6275:
6274:
6269:
6264:
6259:
6254:
6249:
6244:
6239:
6237:Methylene blue
6234:
6208:
6203:
6198:
6196:CX157 (Tyrima)
6193:
6188:
6183:
6178:
6173:
6168:
6156:
6153:
6152:
6150:
6149:
6144:
6139:
6134:
6129:
6124:
6119:
6114:
6109:
6104:
6099:
6094:
6089:
6084:
6079:
6074:
6069:
6064:
6059:
6054:
6049:
6044:
6039:
6034:
6029:Non-selective:
6022:
6021:
6012:
6003:
5994:
5981:
5972:
5959:
5928:
5922:
5911:
5910:
5908:
5907:
5902:
5897:
5892:
5887:
5878:
5877:
5868:
5856:
5854:Phenethylamine
5847:
5835:
5826:
5810:
5808:
5794:
5790:
5789:
5778:
5776:
5775:
5768:
5761:
5753:
5744:
5743:
5741:
5740:
5727:
5714:
5701:
5688:
5675:
5662:
5648:
5646:
5642:
5641:
5639:
5638:
5633:
5628:
5623:
5618:
5612:
5610:
5606:
5605:
5603:
5602:
5597:
5592:
5587:
5581:
5579:
5578:Classification
5575:
5574:
5572:
5571:
5566:
5561:
5556:
5550:
5548:
5544:
5543:
5541:
5540:
5535:
5530:
5525:
5520:
5515:
5510:
5505:
5499:
5497:
5493:
5492:
5487:
5485:
5484:
5477:
5470:
5462:
5453:
5452:
5450:
5449:
5444:
5438:
5436:
5429:
5428:
5426:
5425:
5419:
5417:
5406:
5405:
5403:
5402:
5388:
5383:
5370:
5364:
5362:
5351:
5350:
5348:
5347:
5342:
5341:
5340:
5335:
5324:
5322:
5307:
5306:
5291:
5289:
5287:
5286:
5279:
5272:
5264:
5255:
5254:
5251:
5250:
5248:
5247:
5236:Cholinesterase
5232:
5230:
5222:
5221:
5219:
5218:
5212:
5210:
5199:
5189:
5188:
5186:
5185:
5166:
5164:
5154:
5153:
5150:
5149:
5147:
5146:
5141:
5136:
5127:
5121:
5119:
5105:
5104:
5101:
5100:
5098:
5097:
5091:
5089:
5081:
5080:
5078:
5077:
5071:
5069:
5058:
5048:
5047:
5044:
5043:
5041:
5040:
5039:
5038:
5033:
5023:
5017:
5015:
5007:
5006:
5004:
5003:
4998:
4993:
4984:
4978:
4976:
4965:
4951:
4950:
4947:
4946:
4944:
4943:
4938:
4932:
4930:
4922:
4921:
4919:
4918:
4912:
4910:
4899:
4886:
4880:
4879:
4870:
4868:
4867:
4860:
4853:
4845:
4836:
4835:
4827:
4824:
4823:
4820:
4819:
4817:
4816:
4811:
4806:
4801:
4796:
4791:
4786:
4781:
4776:
4771:
4766:
4761:
4756:
4751:
4746:
4741:
4736:
4731:
4726:
4721:
4716:
4711:
4705:
4703:
4695:
4694:
4692:
4691:
4686:
4680:
4678:
4670:
4669:
4667:
4666:
4661:
4656:
4650:
4648:
4640:
4639:
4637:
4636:
4630:
4628:
4620:
4619:
4617:
4616:
4611:
4606:
4601:
4596:
4591:
4586:
4580:
4578:
4567:
4561:
4560:
4557:
4556:
4554:
4553:
4548:
4547:
4546:
4541:
4531:
4525:
4519:
4515:
4514:
4511:
4510:
4508:
4507:
4501:
4498:
4497:
4495:
4494:
4488:
4486:
4478:
4477:
4475:
4474:
4469:
4464:
4458:
4456:
4446:
4445:
4443:
4442:
4437:
4432:
4426:
4424:
4414:
4413:
4411:
4410:
4405:
4400:
4395:
4390:
4385:
4380:
4374:
4372:
4359:
4353:
4352:
4349:
4348:
4346:
4345:
4340:
4335:
4330:
4325:
4319:
4317:
4309:
4308:
4306:
4305:
4300:
4295:
4289:
4287:
4277:
4276:
4274:
4273:
4268:
4262:
4260:
4250:
4249:
4247:
4246:
4240:
4238:
4228:
4227:
4225:
4224:
4219:
4214:
4209:
4203:
4201:
4188:
4186:Inner membrane
4182:
4181:
4179:
4178:
4173:
4167:
4165:
4159:
4158:
4155:
4154:
4152:
4151:
4145:
4143:
4131:
4130:
4128:
4127:
4121:
4119:
4108:
4107:
4105:
4104:
4099:
4093:
4091:
4078:
4076:Outer membrane
4072:
4071:
4065:
4063:
4062:
4055:
4048:
4040:
4033:
4032:
4017:(in Russian).
4005:
3962:
3918:Human Genetics
3904:
3902:
3901:
3899:on 2007-09-30.
3841:
3834:
3816:
3765:
3746:(3): 207–210.
3724:
3689:(2): 213–219.
3667:
3632:(3): 325–336.
3614:
3560:
3510:
3487:
3456:
3410:
3383:(1–2): 21–30.
3367:
3318:
3275:
3232:
3183:
3154:(3): 269–293.
3134:
3085:
3042:
3014:
2987:(1–2): 79–89.
2971:
2927:
2891:
2856:
2821:
2802:(4): 353–364.
2783:
2763:
2738:Pharmacol Ther
2725:
2700:Agents Actions
2690:
2671:(3): 507–535.
2665:Drug Metab Rev
2648:
2613:
2588:Pharmacol Ther
2578:
2527:
2508:(2): 131–139.
2502:Auton Neurosci
2484:
2433:
2398:
2363:
2356:
2330:
2305:
2266:
2231:
2182:
2163:(9): 1139–62.
2146:
2117:(5): 365–377.
2097:
2070:
2063:
2044:
2025:(2): 111–116.
2002:
1983:(3): 204–207.
1964:
1915:
1877:
1826:
1812:
1769:
1720:
1671:
1621:
1619:
1616:
1615:
1614:
1609:
1604:
1600:
1593:
1590:
1581:
1578:
1517:Dunedin cohort
1497:
1494:
1479:
1476:
1447:
1444:
1442:
1439:
1433:traits. These
1424:vervet monkeys
1411:
1408:
1392:
1389:
1358:norepinephrine
1350:catecholamines
1320:
1317:
1214:sympatholytics
1201:compounds and
1164:
1163:
1154:
1144:
1137:Phenethylamine
1134:
1124:
1114:
1104:
1094:
1087:Norepinephrine
1084:
1074:
1064:
1050:
1036:
1035:
1020:
1013:Phenethylamine
1010:
1003:norepinephrine
964:
961:
870:
867:
842:
841:
840:
839:
829:
800:
776:
773:
754:protein family
710:
709:
706:
705:
700:
696:
695:
690:
686:
685:
677:
676:
666:
660:
659:
655:
654:
649:
643:
642:
637:
631:
630:
625:
619:
618:
613:
607:
606:
601:
595:
594:
589:
585:
584:
580:
579:
566:
558:
557:
547:
546:
543:
542:
537:
533:
532:
527:
523:
522:
514:
513:
503:
497:
496:
492:
491:
486:
480:
479:
474:
468:
467:
462:
456:
455:
450:
444:
443:
438:
432:
431:
426:
422:
421:
417:
416:
398:outer membrane
382:Ribbon diagram
380:
372:
371:
361:
360:
357:
356:
351:
345:
344:
331:
325:
324:
314:
307:
306:
298:
297:
292:
286:
285:
280:
274:
273:
268:
262:
261:
256:
250:
249:
244:
238:
237:
234:
230:
229:
225:
224:
216:
215:
212:
211:
206:
200:
199:
194:
188:
187:
182:
176:
175:
167:
166:
157:
151:
150:
139:
132:
131:
126:
120:
119:
114:
108:
107:
102:
96:
95:
90:
84:
83:
78:
72:
71:
66:
60:
59:
55:
54:
49:
43:
42:
37:
31:
30:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
7240:
7229:
7226:
7224:
7221:
7219:
7216:
7214:
7211:
7210:
7208:
7198:
7193:
7188:
7184:
7172:
7171:
7167:
7163:
7159:
7158:Serotonergics
7155:
7154:Melatonergics
7151:
7150:Dopaminergics
7147:
7143:
7140:
7133:
7123:
7120:
7117:
7116:
7113:
7109:
7106:
7103:
7102:
7100:
7095:
7089:
7083:
7080:
7078:
7075:
7073:
7070:
7068:
7065:
7063:
7060:
7058:
7055:
7053:
7050:
7047:
7046:
7043:
7039:
7036:
7033:
7032:
7030:
7025:
7019:
7013:
7010:
7008:
7005:
7003:
7000:
6998:
6995:
6993:
6990:
6988:
6985:
6982:
6981:
6978:
6974:
6968:
6965:
6964:
6962:
6957:
6951:
6948:
6946:
6942:
6932:
6928:
6925:
6922:
6921:
6919:
6914:
6908:
6902:
6898:
6895:
6892:
6891:
6889:
6884:
6878:
6872:
6869:
6867:
6864:
6862:
6859:
6856:
6855:
6852:
6848:
6845:
6842:
6841:
6839:
6834:
6828:
6825:
6821:
6817:
6811:
6807:
6797:
6794:
6792:
6789:
6787:
6784:
6782:
6779:
6777:
6774:
6772:
6769:
6767:
6764:
6762:
6759:
6756:
6755:
6752:
6748:
6745:
6743:
6739:
6736:
6734:
6730:
6727:
6725:
6721:
6718:
6716:
6712:
6709:
6707:
6703:
6700:
6698:
6694:
6691:
6689:
6685:
6682:
6680:
6676:
6673:
6671:
6667:
6664:
6661:
6660:
6658:
6653:
6647:
6641:
6638:
6636:
6633:
6631:
6628:
6625:
6624:
6621:
6617:
6614:
6611:
6610:
6608:
6603:
6597:
6591:
6588:
6586:
6583:
6581:
6578:
6576:
6573:
6571:
6568:
6566:
6563:
6561:
6558:
6555:
6554:
6551:
6547:
6544:
6541:
6540:
6538:
6533:
6527:
6521:
6518:
6516:
6513:
6511:
6508:
6506:
6503:
6501:
6498:
6496:
6493:
6491:
6488:
6485:
6484:
6481:
6474:
6471:
6468:
6467:
6465:
6460:
6454:
6448:
6445:
6442:
6441:
6438:
6434:
6433:Phenylalanine
6431:
6428:
6427:
6425:
6420:
6414:
6411:
6407:
6402:
6398:
6392:
6388:
6374:
6371:
6369:
6366:
6364:
6357:
6355:
6352:
6350:
6347:
6345:
6342:
6340:
6337:
6335:
6332:
6330:
6327:
6325:
6322:
6320:
6317:
6315:
6312:
6310:
6307:
6305:
6299:
6297:
6294:
6292:
6289:
6286:
6283:
6282:
6279:
6273:
6270:
6268:
6265:
6263:
6260:
6258:
6255:
6253:
6250:
6248:
6245:
6243:
6240:
6238:
6235:
6232:
6228:
6224:
6220:
6216:
6212:
6209:
6207:
6204:
6202:
6199:
6197:
6194:
6192:
6189:
6187:
6184:
6182:
6179:
6177:
6174:
6172:
6169:
6167:
6164:
6161:
6158:
6157:
6154:
6148:
6145:
6143:
6140:
6138:
6135:
6133:
6130:
6128:
6125:
6123:
6120:
6118:
6115:
6113:
6110:
6108:
6105:
6103:
6100:
6098:
6097:Metfendrazine
6095:
6093:
6090:
6088:
6085:
6083:
6080:
6078:
6077:Isocarboxazid
6075:
6073:
6070:
6068:
6065:
6063:
6060:
6058:
6055:
6053:
6050:
6048:
6045:
6043:
6042:Echinopsidine
6040:
6038:
6035:
6033:
6030:
6027:
6024:
6023:
6020:
6016:
6013:
6011:
6007:
6004:
6002:
5998:
5995:
5993:
5989:
5985:
5982:
5980:
5976:
5973:
5971:
5967:
5963:
5960:
5958:
5954:
5951:
5946:
5937:
5930:
5929:
5926:
5923:
5918:
5912:
5906:
5903:
5901:
5898:
5896:
5893:
5891:
5888:
5886:
5883:
5880:
5879:
5876:
5872:
5869:
5867:
5863:
5857:
5855:
5851:
5850:Phenylalanine
5848:
5846:
5842:
5836:
5834:
5830:
5827:
5825:
5821:
5815:
5812:
5811:
5809:
5804:
5798:
5795:
5791:
5787:
5784:
5781:
5774:
5769:
5767:
5762:
5760:
5755:
5754:
5751:
5738:
5734:
5733:
5728:
5725:
5721:
5720:
5715:
5712:
5708:
5707:
5702:
5699:
5695:
5694:
5689:
5686:
5682:
5681:
5676:
5673:
5669:
5668:
5663:
5660:
5656:
5655:
5650:
5649:
5647:
5643:
5637:
5634:
5632:
5629:
5627:
5624:
5622:
5619:
5617:
5614:
5613:
5611:
5607:
5601:
5598:
5596:
5595:Enzyme family
5593:
5591:
5588:
5586:
5583:
5582:
5580:
5576:
5570:
5567:
5565:
5562:
5560:
5559:Cooperativity
5557:
5555:
5552:
5551:
5549:
5545:
5539:
5536:
5534:
5531:
5529:
5526:
5524:
5521:
5519:
5518:Oxyanion hole
5516:
5514:
5511:
5509:
5506:
5504:
5501:
5500:
5498:
5494:
5490:
5483:
5478:
5476:
5471:
5469:
5464:
5463:
5460:
5448:
5445:
5443:
5440:
5439:
5437:
5434:
5430:
5424:
5421:
5420:
5418:
5415:
5411:
5407:
5400:
5396:
5392:
5391:Primary-amine
5389:
5387:
5384:
5382:
5378:
5374:
5373:Amine oxidase
5371:
5369:
5366:
5365:
5363:
5360:
5356:
5352:
5346:
5343:
5339:
5336:
5334:
5331:
5330:
5329:
5326:
5325:
5323:
5320:
5316:
5312:
5308:
5304:
5300:
5296:
5285:
5280:
5278:
5273:
5271:
5266:
5265:
5262:
5245:
5241:
5237:
5234:
5233:
5231:
5228:
5223:
5217:
5214:
5213:
5211:
5208:
5203:
5200:
5198:
5197:Acetylcholine
5194:
5190:
5183:
5179:
5175:
5171:
5168:
5167:
5165:
5163:
5159:
5155:
5145:
5142:
5140:
5137:
5135:
5128:
5126:
5123:
5122:
5120:
5118:
5114:
5110:
5106:
5096:
5093:
5092:
5090:
5087:
5082:
5076:
5073:
5072:
5070:
5067:
5062:
5059:
5057:
5053:
5049:
5037:
5034:
5032:
5029:
5028:
5027:
5024:
5022:
5019:
5018:
5016:
5013:
5008:
5002:
4999:
4997:
4994:
4992:
4985:
4983:
4980:
4979:
4977:
4974:
4969:
4966:
4964:
4960:
4956:
4952:
4942:
4939:
4937:
4934:
4933:
4931:
4928:
4923:
4917:
4914:
4913:
4911:
4908:
4903:
4900:
4898:
4894:
4890:
4887:
4885:
4881:
4877:
4873:
4866:
4861:
4859:
4854:
4852:
4847:
4846:
4843:
4833:
4832:
4825:
4815:
4812:
4810:
4807:
4805:
4802:
4800:
4797:
4795:
4792:
4790:
4787:
4785:
4782:
4780:
4777:
4775:
4772:
4770:
4767:
4765:
4762:
4760:
4757:
4755:
4752:
4750:
4747:
4745:
4742:
4740:
4737:
4735:
4732:
4730:
4727:
4725:
4722:
4720:
4717:
4715:
4712:
4710:
4707:
4706:
4704:
4701:
4696:
4690:
4687:
4685:
4682:
4681:
4679:
4676:
4671:
4665:
4662:
4660:
4657:
4655:
4652:
4651:
4649:
4646:
4641:
4635:
4632:
4631:
4629:
4626:
4621:
4615:
4612:
4610:
4607:
4605:
4602:
4600:
4597:
4595:
4592:
4590:
4587:
4585:
4582:
4581:
4579:
4576:
4571:
4568:
4566:
4562:
4552:
4549:
4545:
4542:
4540:
4537:
4536:
4535:
4532:
4530:
4527:
4526:
4523:
4520:
4516:
4506:
4503:
4502:
4499:
4493:
4490:
4489:
4487:
4484:
4479:
4473:
4470:
4468:
4465:
4463:
4460:
4459:
4457:
4454:
4453:
4447:
4441:
4438:
4436:
4433:
4431:
4428:
4427:
4425:
4422:
4421:
4415:
4409:
4406:
4404:
4401:
4399:
4396:
4394:
4391:
4389:
4386:
4384:
4381:
4379:
4376:
4375:
4373:
4370:
4369:
4363:
4360:
4358:
4354:
4344:
4341:
4339:
4336:
4334:
4331:
4329:
4326:
4324:
4321:
4320:
4318:
4315:
4310:
4304:
4301:
4299:
4296:
4294:
4291:
4290:
4288:
4285:
4284:
4278:
4272:
4269:
4267:
4264:
4263:
4261:
4258:
4257:
4251:
4245:
4242:
4241:
4239:
4236:
4235:
4229:
4223:
4220:
4218:
4215:
4213:
4210:
4208:
4205:
4204:
4202:
4199:
4198:
4192:
4189:
4187:
4183:
4177:
4174:
4172:
4169:
4168:
4166:
4164:
4160:
4150:
4147:
4146:
4144:
4141:
4138:
4132:
4126:
4123:
4122:
4120:
4117:
4115:
4109:
4103:
4100:
4098:
4095:
4094:
4092:
4089:
4088:
4082:
4079:
4077:
4073:
4068:
4067:Mitochondrial
4061:
4056:
4054:
4049:
4047:
4042:
4041:
4038:
4028:
4024:
4020:
4016:
4009:
4006:
4001:
3997:
3993:
3989:
3985:
3981:
3977:
3973:
3966:
3963:
3951:
3947:
3943:
3939:
3935:
3931:
3927:
3923:
3919:
3915:
3908:
3905:
3898:
3894:
3890:
3885:
3884:
3881:
3877:
3873:
3869:
3865:
3861:
3857:
3853:
3845:
3842:
3837:
3831:
3827:
3820:
3817:
3812:
3808:
3804:
3800:
3796:
3792:
3788:
3784:
3780:
3776:
3769:
3766:
3761:
3757:
3753:
3749:
3745:
3741:
3740:
3735:
3728:
3725:
3720:
3716:
3712:
3708:
3704:
3700:
3696:
3692:
3688:
3684:
3683:
3678:
3671:
3668:
3663:
3659:
3655:
3651:
3647:
3643:
3639:
3635:
3631:
3627:
3626:
3618:
3615:
3610:
3606:
3602:
3598:
3594:
3590:
3586:
3582:
3578:
3574:
3567:
3565:
3561:
3556:
3552:
3548:
3544:
3540:
3536:
3532:
3528:
3527:
3519:
3517:
3515:
3511:
3506:
3502:
3498:
3494:
3490:
3484:
3480:
3476:
3472:
3471:
3463:
3461:
3457:
3452:
3448:
3444:
3440:
3436:
3432:
3428:
3424:
3417:
3415:
3411:
3406:
3402:
3398:
3394:
3390:
3386:
3382:
3378:
3371:
3368:
3363:
3359:
3354:
3349:
3345:
3341:
3338:(4): 869–88.
3337:
3333:
3329:
3322:
3319:
3314:
3310:
3306:
3302:
3298:
3294:
3290:
3286:
3279:
3276:
3271:
3267:
3263:
3259:
3255:
3251:
3248:(2): 152–71.
3247:
3243:
3236:
3233:
3228:
3224:
3219:
3214:
3210:
3206:
3203:(4): 239–48.
3202:
3198:
3194:
3187:
3184:
3179:
3175:
3170:
3165:
3161:
3157:
3153:
3149:
3145:
3138:
3135:
3130:
3124:
3116:
3112:
3108:
3104:
3100:
3096:
3089:
3086:
3081:
3077:
3073:
3069:
3065:
3061:
3058:(2): 149–53.
3057:
3053:
3046:
3043:
3038:
3034:
3031:(5): 269–74.
3030:
3026:
3018:
3015:
3010:
3006:
3002:
2998:
2994:
2990:
2986:
2982:
2975:
2972:
2967:
2963:
2959:
2955:
2951:
2947:
2943:
2939:
2931:
2928:
2923:
2919:
2915:
2911:
2907:
2903:
2895:
2892:
2887:
2883:
2879:
2875:
2872:(4): 438–40.
2871:
2867:
2860:
2857:
2852:
2848:
2844:
2840:
2836:
2832:
2825:
2822:
2817:
2813:
2809:
2805:
2801:
2797:
2790:
2788:
2784:
2779:
2778:
2770:
2768:
2764:
2759:
2755:
2751:
2747:
2743:
2739:
2732:
2730:
2726:
2721:
2717:
2713:
2709:
2705:
2701:
2694:
2691:
2686:
2682:
2678:
2674:
2670:
2666:
2659:
2657:
2655:
2653:
2649:
2644:
2640:
2636:
2632:
2628:
2624:
2617:
2614:
2609:
2605:
2601:
2597:
2593:
2589:
2582:
2579:
2574:
2570:
2565:
2560:
2555:
2550:
2546:
2542:
2541:Pharmaceutics
2538:
2531:
2528:
2523:
2519:
2515:
2511:
2507:
2503:
2495:
2493:
2491:
2489:
2485:
2480:
2476:
2471:
2466:
2461:
2456:
2452:
2448:
2444:
2437:
2434:
2429:
2425:
2421:
2417:
2413:
2409:
2402:
2399:
2394:
2390:
2386:
2382:
2379:(2): 95–109.
2378:
2374:
2367:
2364:
2359:
2353:
2349:
2345:
2341:
2334:
2331:
2326:
2322:
2317:
2312:
2308:
2302:
2298:
2294:
2290:
2286:
2282:
2275:
2273:
2271:
2267:
2262:
2258:
2254:
2250:
2246:
2242:
2235:
2232:
2227:
2223:
2218:
2213:
2209:
2205:
2201:
2197:
2193:
2186:
2183:
2178:
2174:
2170:
2166:
2162:
2158:
2150:
2147:
2142:
2138:
2133:
2128:
2124:
2120:
2116:
2112:
2108:
2101:
2098:
2093:
2089:
2085:
2081:
2074:
2071:
2066:
2060:
2056:
2048:
2045:
2040:
2036:
2032:
2028:
2024:
2020:
2013:
2011:
2009:
2007:
2003:
1998:
1994:
1990:
1986:
1982:
1978:
1971:
1969:
1965:
1960:
1956:
1951:
1946:
1942:
1938:
1935:(6): 863–71.
1934:
1930:
1926:
1919:
1916:
1911:
1907:
1903:
1899:
1895:
1891:
1887:
1881:
1878:
1873:
1869:
1864:
1859:
1854:
1849:
1845:
1841:
1837:
1830:
1827:
1822:
1816:
1813:
1808:
1804:
1800:
1796:
1792:
1788:
1784:
1780:
1773:
1770:
1765:
1761:
1756:
1751:
1747:
1743:
1740:(4): 968–79.
1739:
1735:
1731:
1724:
1721:
1716:
1710:
1702:
1698:
1694:
1690:
1686:
1682:
1675:
1672:
1667:
1661:
1653:
1649:
1645:
1641:
1637:
1633:
1626:
1623:
1617:
1613:
1610:
1608:
1601:
1599:
1598:Cheese effect
1596:
1595:
1591:
1589:
1587:
1579:
1577:
1575:
1571:
1567:
1563:
1558:
1556:
1552:
1547:
1545:
1539:
1536:
1531:
1526:
1522:
1518:
1513:
1511:
1507:
1503:
1495:
1493:
1491:
1487:
1486:
1477:
1475:
1473:
1472:
1467:
1463:
1462:
1457:
1456:chlordimeform
1453:
1445:
1440:
1438:
1436:
1435:knockout mice
1432:
1431:autistic-like
1427:
1425:
1421:
1417:
1410:Animal models
1409:
1407:
1405:
1401:
1397:
1390:
1388:
1386:
1382:
1377:
1375:
1371:
1367:
1363:
1359:
1355:
1351:
1346:
1342:
1338:
1334:
1330:
1329:schizophrenia
1326:
1318:
1316:
1314:
1310:
1306:
1302:
1298:
1294:
1290:
1286:
1282:
1278:
1274:
1270:
1266:
1262:
1258:
1254:
1250:
1246:
1242:
1238:
1234:
1231:
1227:
1223:
1219:
1218:phenylephrine
1215:
1211:
1208:
1204:
1200:
1196:
1191:
1189:
1185:
1181:
1177:
1173:
1169:
1162:
1158:
1155:
1152:
1148:
1145:
1142:
1138:
1135:
1132:
1128:
1125:
1122:
1118:
1115:
1112:
1108:
1105:
1102:
1098:
1095:
1092:
1088:
1085:
1082:
1078:
1075:
1072:
1068:
1065:
1062:
1058:
1054:
1051:
1048:
1044:
1041:
1040:
1039:
1033:
1029:
1025:
1021:
1018:
1014:
1011:
1008:
1004:
1000:
997:
996:
995:
993:
992:specificities
989:
985:
981:
978:
974:
970:
962:
960:
958:
954:
950:
946:
942:
938:
937:flavoproteins
934:
931:
927:
923:
919:
915:
911:
907:
903:
899:
895:
891:
888:
884:
875:
868:
866:
862:
860:
856:
852:
848:
837:
834:
830:
827:
823:
819:
816:
812:
808:
807:
805:
801:
798:
794:
790:
789:
788:
786:
782:
774:
772:
770:
766:
761:
759:
755:
751:
750:Mary Bernheim
747:
743:
739:
735:
731:
727:
724:
720:
716:
704:
701:
697:
694:
691:
687:
682:
678:
675:
674:
670:
667:
665:
661:
656:
653:
650:
648:
644:
641:
638:
636:
632:
629:
626:
624:
620:
617:
614:
612:
608:
605:
602:
600:
596:
593:
590:
586:
581:
575:
571:
564:
559:
556:
552:
541:
538:
534:
531:
528:
524:
519:
515:
512:
511:
507:
504:
502:
498:
493:
490:
487:
485:
481:
478:
475:
473:
469:
466:
463:
461:
457:
454:
451:
449:
445:
442:
439:
437:
433:
430:
427:
423:
418:
412:
408:
403:
402:mitochondrion
399:
395:
391:
387:
383:
378:
373:
370:
366:
355:
352:
350:
346:
343:
339:
335:
332:
330:
326:
322:
318:
315:
312:
308:
303:
299:
296:
293:
291:
287:
284:
281:
279:
275:
272:
269:
267:
263:
260:
257:
255:
251:
248:
245:
243:
239:
235:
231:
226:
221:
210:
207:
205:
201:
198:
195:
193:
189:
186:
183:
181:
177:
172:
168:
165:
161:
158:
156:
155:Gene Ontology
152:
149:
146:
143:
140:
137:
133:
130:
127:
125:
121:
118:
115:
113:
109:
106:
103:
101:
97:
94:
93:NiceZyme view
91:
89:
85:
82:
79:
77:
73:
70:
67:
65:
61:
56:
53:
50:
48:
44:
41:
38:
36:
32:
27:
22:
19:
7138:
7137:
7118:
7104:
7048:
7034:
7012:Tritoqualine
6983:
6966:
6923:
6893:
6857:
6843:
6791:Quinalizarin
6776:Neluxicapone
6757:
6697:Metanephrine
6662:
6626:
6612:
6575:Fusaric acid
6556:
6542:
6510:Bulbocapnine
6486:
6469:
6443:
6429:
6373:Tisolagiline
6368:Sembragiline
6359:Selegiline (
6287:
6284:
6262:Sercloremine
6242:Metralindole
6162:
6159:
6137:Procarbazine
6132:Pivhydrazine
6122:Pheniprazine
6047:Furazolidone
6028:
6025:
5962:Metanephrine
5931:
5914:
5881:
5813:
5793:Non-specific
5732:Translocases
5729:
5716:
5703:
5690:
5677:
5667:Transferases
5664:
5651:
5508:Binding site
5398:
5394:
5226:
5206:
5085:
5065:
5025:
5011:
4972:
4926:
4906:
4874:involved in
4828:
4675:ATP synthase
4482:
4450:
4418:
4366:
4333:ATP synthase
4313:
4281:
4254:
4232:
4212:Cytochrome c
4195:
4148:
4135:
4125:Kynureninase
4112:
4085:
4021:(3): 402–5.
4018:
4014:
4008:
3975:
3971:
3965:
3954:. Retrieved
3924:(3): 273–9.
3921:
3917:
3907:
3897:the original
3892:
3855:
3851:
3844:
3825:
3819:
3778:
3774:
3768:
3743:
3737:
3733:
3727:
3686:
3680:
3676:
3670:
3629:
3623:
3617:
3576:
3572:
3530:
3524:
3468:
3434:
3430:
3426:
3422:
3380:
3376:
3370:
3335:
3331:
3321:
3291:(1): 27–33.
3288:
3284:
3278:
3245:
3241:
3235:
3200:
3196:
3186:
3151:
3147:
3137:
3123:cite journal
3098:
3094:
3088:
3055:
3051:
3045:
3028:
3024:
3017:
2984:
2980:
2974:
2944:(1): 110–4.
2941:
2937:
2930:
2905:
2901:
2894:
2869:
2865:
2859:
2837:(3): 323–6.
2834:
2830:
2824:
2799:
2795:
2776:
2741:
2737:
2703:
2699:
2693:
2668:
2664:
2626:
2622:
2616:
2591:
2587:
2581:
2544:
2540:
2530:
2505:
2501:
2450:
2446:
2436:
2414:(1): 17–24.
2411:
2407:
2401:
2376:
2373:Pharmacology
2372:
2366:
2339:
2333:
2288:
2284:
2244:
2240:
2234:
2199:
2195:
2185:
2160:
2156:
2149:
2114:
2110:
2100:
2083:
2079:
2073:
2054:
2047:
2022:
2018:
1980:
1976:
1932:
1928:
1918:
1893:
1889:
1880:
1843:
1839:
1829:
1815:
1785:(5–6): 373.
1782:
1778:
1772:
1737:
1733:
1723:
1709:cite journal
1684:
1680:
1674:
1660:cite journal
1635:
1631:
1625:
1586:pineal gland
1583:
1566:warrior gene
1559:
1548:
1543:
1540:
1514:
1506:X chromosome
1499:
1489:
1483:
1481:
1469:
1459:
1452:insecticides
1449:
1428:
1426:and humans.
1413:
1400:trypanosomes
1398:- caused by
1394:
1378:
1372:may lead to
1322:
1192:
1165:
1161:benzaldehyde
1117:Metanephrine
1037:
973:pharmacology
966:
880:
863:
847:hypothalamus
843:
802:Outside the
778:
762:
746:mitochondria
718:
714:
713:
671:
508:
81:BRENDA entry
18:
7228:Amphetamine
7146:Adrenergics
7119:Inhibitors:
7052:Amodiaquine
7049:Inhibitors:
6984:Inhibitors:
6858:Inhibitors:
6810:Tryptamines
6758:Inhibitors:
6693:Epinephrine
6627:Inhibitors:
6557:Inhibitors:
6505:Aquayamycin
6487:Inhibitors:
6444:Inhibitors:
6401:epinephrine
6291:Adarigiline
6285:Inhibitors:
6252:Moclobemide
6181:Brofaromine
6176:Befloxatone
6171:Bazinaprine
6160:Inhibitors:
6067:Iproclozide
6057:Hydralazine
6026:Inhibitors:
5948:Tooltip ALR
5885:Benserazide
5882:Inhibitors:
5503:Active site
5227:catabolism:
5086:catabolism:
5012:catabolism:
4963:epinephrine
4927:catabolism:
4625:Complex III
3858:(2): 55–8.
2594:: 137–180.
2196:Exp Mol Med
1564:), dubbed "
1535:sympathetic
1354:epinephrine
1311:metabolite
1305:Haloperidol
1301:ticlopidine
1293:rivaroxaban
1285:nomifensine
1257:sumatriptan
1253:rizatriptan
1249:almotriptan
1226:pronethalol
1222:propranolol
1157:Benzylamine
1097:Epinephrine
1017:benzylamine
1007:epinephrine
941:hydrophobic
818:endothelium
693:Swiss-model
673:p11.4-p11.3
583:Identifiers
530:Swiss-model
510:p11.4-p11.3
420:Identifiers
278:OPM protein
228:Identifiers
69:IntEnz view
29:Identifiers
7207:Categories
7072:Quinacrine
7007:Naringenin
7002:Meciadanol
6973:-Histidine
6847:Tryptophan
6781:Nitecapone
6771:Entacapone
6630:CGS-19281A
6580:Nepicastat
6565:Disulfiram
6560:Bupicomide
6515:Metirosine
6363:-Deprenyl)
6354:Safinamide
6349:Rasagiline
6334:Mofegiline
6329:Milacemide
6324:Lazabemide
6319:Ladostigil
6296:Almoxatone
6272:Toloxatone
6267:Tetrindole
6257:Pirlindole
6201:Eprobemide
6191:Clorgiline
6186:Cimoxatone
6166:Amiflamine
6117:Phenelzine
6112:Paraxazone
6092:Mebanazine
6072:Iproniazid
6062:Indantadol
6052:Guineesine
6037:Caroxazone
5905:Methyldopa
5875:Tryptamine
5871:Tryptophan
5841:-Histidine
5786:modulators
5783:metabolism
5706:Isomerases
5680:Hydrolases
5547:Regulation
5207:anabolism:
5109:tryptophan
5066:anabolism:
4973:anabolism:
4907:anabolism:
4645:Complex IV
4452:urea cycle
4140:metabolism
4116:metabolism
4114:tryptophan
3956:2021-03-30
3893:Media Life
2744:: 108020.
2547:(2): 693.
1618:References
1441:Arthropods
1333:depression
1309:neurotoxic
1297:sertraline
1289:primaquine
1277:milacemide
1265:citalopram
1261:bicifadine
1195:endogenous
1067:Tryptamine
1032:tryptamine
984:catabolism
742:monoamines
689:Structures
684:Search for
658:Other data
526:Structures
521:Search for
495:Other data
394:clorgiline
317:structures
290:Membranome
138:structures
105:KEGG entry
52:9001-66-5
7139:See also:
7108:Histamine
7077:SKF-91488
7067:Metoprine
7062:Harmaline
7038:Histamine
6977:Histamine
6945:Histamine
6931:Melatonin
6897:Serotonin
6820:melatonin
6816:serotonin
6796:Tolcapone
6786:Opicapone
6635:SKF-64139
6590:Tropolone
6344:Pargyline
6304:-Deprenyl
6247:Minaprine
6227:norharman
6219:harmaline
6142:Safrazine
6107:Octamoxin
6102:Nialamide
6087:Linezolid
6082:Isoniazid
6015:Serotonin
5900:Genistein
5890:Carbidopa
5862:-Tyrosine
5845:Histamine
5833:Serotonin
5780:Monoamine
5585:EC number
5414:disulfide
5399:Monoamine
5130:Aromatic
5117:melatonin
5113:serotonin
5052:glutamate
4987:Aromatic
4897:histamine
4893:histidine
4884:monoamine
4829:see also
4575:Complex I
4383:Aconitase
3711:0048-3575
3654:0048-3575
3555:0048-3575
3497:0065-2806
3270:207406469
2816:1573-4005
2453:(1): 34.
2291:: 13–42.
1576:variant.
1370:serotonin
1269:CP-409092
1245:bufotenin
1241:5-MeO-DMT
1199:exogenous
1180:precursor
1172:histamine
1057:melatonin
1043:Serotonin
999:Serotonin
836:platelets
797:astroglia
738:oxidation
640:NM_000898
599:NCBI gene
477:NM_000240
436:NCBI gene
259:IPR001613
58:Databases
7218:EC 1.4.3
6987:Catechin
6861:AGN-2979
6666:Dopamine
6640:SKF-7698
6570:Dopastin
6546:Dopamine
6520:Oudenone
6473:Tyrosine
6437:Tyrosine
6397:dopamine
6339:Nicotine
6206:Esuprone
6032:Benmoxin
5997:Dopamine
5866:Tyramine
5824:Dopamine
5609:Kinetics
5533:Cofactor
5496:Activity
5416:acceptor
5361:acceptor
5321:acceptor
5158:arginine
4959:dopamine
4955:tyrosine
4529:Frataxin
4403:Fumarase
4069:proteins
4027:19432173
4000:14697890
3950:Archived
3946:29954052
3880:25418973
3872:16538181
3803:12161658
3760:83731654
3719:84947221
3662:83944360
3505:83010475
3451:29861405
3405:14697877
3362:22850464
3313:30722852
3262:19995590
3227:15552546
3178:32931110
3115:15279566
3072:15694196
3009:14697883
2966:24453719
2958:15717295
2922:17088501
2758:34637840
2643:30374594
2608:31128989
2573:36840015
2522:11958479
2479:23683503
2428:18155917
2393:20130443
2325:21971001
2261:29637260
2226:34244591
2177:11559028
2141:22022344
2039:88975594
1959:23403377
1910:15279563
1872:31191248
1807:35565156
1799:10643441
1764:16744124
1701:15279562
1652:15279561
1607:receptor
1592:See also
1574:promoter
1562:genotype
1555:genotype
1521:promoter
1496:Genetics
1466:dieldrin
1406:system.
1362:dopamine
1193:Besides
1190:(GABA).
1147:Tyramine
1077:Dopamine
1028:tyramine
1024:dopamine
945:tyrosine
930:cofactor
926:oxidases
906:aldehyde
887:cofactor
869:Function
851:striatum
826:placenta
734:catalyze
703:InterPro
577:.
540:InterPro
414:.
334:RCSB PDB
254:InterPro
209:proteins
197:articles
185:articles
142:RCSB PDB
7197:Biology
7082:Tacrine
6314:Ethanol
6215:harmine
6213:(e.g.,
5719:Ligases
5489:Enzymes
5386:Diamine
5193:choline
4872:Enzymes
4689:MT-ATP8
4684:MT-ATP6
4604:MT-ND4L
3980:Bibcode
3938:9799080
3811:7882492
3783:Bibcode
3775:Science
3691:Bibcode
3634:Bibcode
3609:4162760
3601:4701207
3581:Bibcode
3535:Bibcode
3385:Bibcode
3353:3517692
3305:6781004
3218:2075358
3169:7491646
2989:Bibcode
2886:1267046
2720:3394581
2685:7924902
2564:9966027
2470:3693914
2316:3371272
2217:8333267
2132:3197729
1997:9550341
1950:3677103
1886:Shih JC
1863:6549493
1846:: 143.
1755:1252213
1464:); and
1446:Insects
1273:KW-2449
1239:(DMT),
1133:(HMPAL)
969:enzymes
910:ammonia
793:neurons
730:enzymes
726:1.4.3.4
699:Domains
647:UniProt
536:Domains
484:UniProt
404:. From
386:monomer
247:PF01593
164:QuickGO
129:profile
112:MetaCyc
47:CAS no.
40:1.4.3.4
7183:Portal
6223:harman
6019:5-HIAA
5693:Lyases
5433:1.4.99
5359:oxygen
4794:MT-TS2
4789:MT-TS1
4759:MT-TL2
4754:MT-TL1
4664:MT-CO3
4659:MT-CO2
4654:MT-CO1
4634:MT-CYB
4614:MT-ND6
4609:MT-ND5
4599:MT-ND4
4594:MT-ND3
4589:MT-ND2
4584:MT-ND1
4357:Matrix
4025:
3998:
3944:
3936:
3878:
3870:
3832:
3809:
3801:
3758:
3717:
3709:
3660:
3652:
3607:
3599:
3573:Nature
3553:
3503:
3495:
3485:
3449:
3443:406057
3441:
3403:
3360:
3350:
3311:
3303:
3268:
3260:
3225:
3215:
3176:
3166:
3113:
3080:572208
3078:
3070:
3037:318025
3035:
3007:
2964:
2956:
2920:
2884:
2851:943955
2849:
2814:
2756:
2718:
2683:
2641:
2606:
2571:
2561:
2520:
2477:
2467:
2426:
2391:
2354:
2323:
2313:
2303:
2259:
2224:
2214:
2175:
2139:
2129:
2061:
2037:
1995:
1957:
1947:
1908:
1870:
1860:
1805:
1797:
1762:
1752:
1699:
1650:
1553:and a
1404:orexin
1360:, and
1299:, and
1255:, and
1224:, and
1174:, and
1153:(HPAL)
1143:(PAAL)
1030:, and
1005:, and
943:. Two
914:Oxygen
908:) and
902:ketone
824:, and
669:Chr. X
652:P27338
635:RefSeq
628:309860
588:Symbol
506:Chr. X
489:P21397
472:RefSeq
465:309850
425:Symbol
349:PDBsum
323:
313:
233:Symbol
192:PubMed
174:Search
160:AmiGO
148:PDBsum
88:ExPASy
76:BRENDA
64:IntEnz
35:EC no.
6882:AANAT
6851:5-HTP
6706:MOPEG
6702:DOPEG
6675:DOPAC
6001:DOPAC
5829:5-HTP
5645:Types
5410:1.4.4
5381:Lysyl
5355:1.4.3
5338:GLUD2
5333:GLUD1
5311:1.4.1
5290:CH-NH
4814:MT-TY
4809:MT-TW
4804:MT-TV
4799:MT-TT
4784:MT-TR
4779:MT-TQ
4774:MT-TP
4769:MT-TN
4764:MT-TM
4749:MT-TK
4744:MT-TI
4739:MT-TH
4734:MT-TG
4729:MT-TF
4724:MT-TE
4719:MT-TD
4714:MT-TC
4709:MT-TA
4505:PMPCB
4492:ALDH2
4314:other
3942:S2CID
3876:S2CID
3807:S2CID
3756:S2CID
3715:S2CID
3679:L.".
3658:S2CID
3605:S2CID
3501:S2CID
3447:S2CID
3309:S2CID
3266:S2CID
3076:S2CID
2962:S2CID
2035:S2CID
1993:S2CID
1803:S2CID
1580:Aging
1570:Māori
1544:other
1502:genes
1490:R. m.
1478:Acari
1420:MAO-B
1416:MAO-A
1235:like
1216:like
1203:drugs
980:drugs
953:MAO-A
949:MAO-B
918:FADH2
898:FADH2
894:imine
833:blood
811:liver
785:MAO-B
781:MAO-A
732:that
664:Locus
501:Locus
400:of a
384:of a
124:PRIAM
7023:HNMT
6912:ASMT
6711:DOMA
6651:COMT
6601:PNMT
5988:MHPG
5979:DHMA
5966:MHPG
5957:DHMA
5935:ALDH
5895:DFMD
5802:AAAD
5737:list
5730:EC7
5724:list
5717:EC6
5711:list
5704:EC5
5698:list
5691:EC4
5685:list
5678:EC3
5672:list
5665:EC2
5659:list
5652:EC1
5393:)) (
5319:NADP
5182:NOS3
5178:NOS2
5174:NOS1
5056:GABA
4700:tRNA
4023:PMID
3996:PMID
3934:PMID
3868:PMID
3830:ISBN
3799:PMID
3707:ISSN
3650:ISSN
3597:PMID
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