343:(OH) end that acts as a signal for the host DNA polymerase to replicate the genome. Replication commences at the 3'-OH end and is performed by extending the 3'-end of the positive strand using the negative strand as a template for replication. {refer to DNA replication} Synthesis of the new positive strand uses the negative strand as a template, and so synthesizes a newly connected strand of DNA which displaces the nicked positive strand to reform double-stranded DNA. The 3'-OH end of the displaced positive strand disrupts the original phosphotyrosine bond which releases and circularizes the displaced positive strand as its own circular copy of viral DNA. After one cycle of replicating the genome, Rep is able to recognize the newly replicated recognition site {recognize the recognition site?} on the reformed double-stranded viral DNA and nick it, which starts the whole process again.
52:
473:. Genetic recombination, or mixture, of ssDNA genomes can occur between closely related viruses when a gene is replicated and transcribed at the same time, which may cause the host cell's DNA polymerases to switch DNA templates (negative strands) during the process, causing recombination. These recombinations usually occur in the negative strand and either outside of or at the peripheries of genes rather than toward the middle of genes.
31:
1325:
497:
origins. HUH endonucleases of CRESS-DNA viruses are most similar to those found in small, RCR bacterial and archael plasmids, extra-chromosomal DNA molecules inside bacteria and archaea, and appear to have evolved from them at least three times. HUH endonucleases of prokaryotic CRESS-DNA viruses seem
520:
appear to have evolved from parvoviruses through inactivation of the endonuclease's HUH domain. The HUH domain then became a DNA-binding domain, changing these viruses' manner of replication to theta bidirectional replication. The capsid proteins of these circular dsDNA viruses are highly divergent,
397:
that repeatedly unfold and refold during replication to change the direction of DNA synthesis to move back and forth along the genome, producing numerous copies of the genome in a continuous process. Individual genomes are then excised from this molecule by the HUH endonuclease. In place of the HUH
354:
of the 5'-end, creating a free circular ssDNA genome that usually is either converted into dsDNA for transcription or further replication or is packaged into newly constructed viral capsids. The replication process can be repeated numerous times on the same circular genome to produce many copies of
476:
The high substitution rate seen in ssDNA viruses is unusual since replication is performed primarily by the host cell's DNA polymerase, which contains proofreading mechanisms to prevent mutations. Substitutions in ssDNA viral genomes may occur because the viral DNA may become oxidatively damaged
1256:
between unrelated organisms that can be used to study evolutionary history. By comparing related organisms, it is possible to estimate the approximate age of ssDNA viruses. For example, comparison of animal genomes has shown that circoviruses and parvoviruses first integrated into their hosts'
1304:
In recent years, analyses of viral DNA in various contexts such as fecal matter and marine sediments have shown that ssDNA viruses are widespread throughout nature, and the increased knowledge of their diversity has helped to greater understand their evolutionary history. The relation between
421:. This begins by unwinding the dsDNA at a site called the origin to separate the two DNA strands from each other. Two replication forks are established that move in opposite directions around the circular genome until they meet at the side opposite of the origin and replication is terminated.
1239:
in cellular organisms, so it can be searched for within an organism's genome to identify if viral DNA has become endogenized as part of the organism's genome. Among eukaryotes, endogenization is most often observed in plants, but it is also observed in animals, fungi, and various protozoans.
505:. Because of this, eukaryotic CRESS-DNA viruses appear to have emerged multiple times from recombination events that merged DNA from bacterial and archaeal plasmids with complementary DNA (cDNA) copies of positive-sense RNA viruses. CRESS-DNA viruses therefore represent a notable instance of
129:
of the circular viral genome. Viruses descended from such viruses are also included in the realm, including certain linear single-stranded DNA (ssDNA) viruses and circular double-stranded DNA (dsDNA) viruses. These atypical members typically replicate through means other than rolling circle
1251:
Most endogenized ssDNA viruses are in non-coding regions of the organism's genome, but sometimes the viral genes are expressed, and the Rep protein may be used by the organism. Because viral DNA can become a part of an organism's genome, this represents an example of
206:
The prototypic members of the realm are often called CRESS-DNA viruses. CRESS-DNA viruses are associated with a wide range of diseases, including diseases in economically important crops and a variety of diseases in animals. The atypical members of the realm include
326:
to produce a double-stranded form of the viral genome. Rep then recognizes a short sequence on the 3'-end ("three prime end") at the origin of replication. Upstream {description needed} from the recognition site, Rep binds to the DNA and nicks the
437:
in shape and composed of either one type of protein or, in the case of parvoviruses, multiple types of proteins. All ssDNA viruses that have had the structure of their capsid proteins analyzed in high resolution have shown to contain a single
521:
so it is unclear if they evolved from parvovirus capsid proteins or through other means. Bidnaviruses, which are linear ssDNA viruses, appear to have been created as a result of a parvovirus genome becoming integrated into the genome of a
2025:
331:
strand, creating a nick {description needed} site. In doing so, Rep binds to the 5'-end (five prime end) via a tyrosine residue that covalently bonds {source for covalent bonds needed} to the phosphate backbone of DNA, creating a
398:
endonuclease, bidnaviruses encode their own protein-primed DNA polymerase that replicates the genome, which is bipartite and packaged into two separate virions, instead of using the host cell's DNA polymerase for replication.
1102:
system, which groups viruses together based on how they produce mRNA, often used alongside standard virus taxonomy, which is based on evolutionary history.. Of the 16 ssDNA virus families, three are not assigned to
1164:
since it appears to be morphologically similar to circoviruses. It has been suggested that anelloviruses are essentially CRESS-DNA viruses with negative sense genomes, unlike the typical positive sense genomes.
2018:
319:
residues. The HUH endonuclease of ssDNA viruses is often called the replication initiation protein, or simply Rep, because its cleavage of a specific site in the viral genome initiates replication.
1283:
infection that caused balding in birds was observed in
Australia in 1888, marking the first reference to ssDNA viruses in modern times. The first animal CRESS-DNA virus to be characterized was the
574:, which only infect bacteria, have filamentous or rod-shaped virions formed from an alpha-helical capsid protein, and encode a morphogenesis protein that is an ATPase of the FtsK-HerA superfamily
2011:
2653:
477:
while the genome is inside the capsid. The prevalence of recombinations and substitutions among ssDNA viruses means that eukaryotic ssDNA viruses can emerge as threatening pathogens.
516:
are likely to have evolved from CRESS-DNA viruses via loss of the joining activity used by CRSS-DNA viruses to create circular genomes. In turn, the circular dsDNA viruses in
501:
The capsid proteins of eukaryotic CRESS-DNA viruses are most closely related those of various animal and plant positive-sense RNA viruses, which belong to the realm
2646:
223:
are also known to frequently become integrated into the DNA of their hosts as well as experience a relatively high rate of genetic mutations and recombinations.
6509:
639:, which only infect bacteria, have a capsid protein that contains a single jelly roll fold, and have a pilot protein required for transferring DNA across the
2581:
1313:
origins, the similar genome structure, genome length, and gene compositions of CRESS-DNA viruses provided the justification to unite them under a realm.
1211:
The atypical members of the realm are also associated with many widely known diseases. Parvoviruses are most widely known for causing a lethal infection
498:
to have originated from plasmid endonucleases that lacked the S3H domain, whereas eukaryotic CRESS-DNA viruses evolved from ones that had S3H domains.
2639:
350:
may be produced in a single strand. After the positive strand is completely detached from the negative strand and nicked, the 3'-OH end bonds to the
1219:
in humans. Papillomaviruses and polyomaviruses are known to cause different types of cancers and other diseases. A polyomavirus is responsible for
451:, unassigned to a realm, which have a negative-sense genome. In any case, ssDNA viruses have their genomes converted to a dsDNA form prior to
367:
have circular ssDNA genomes and replicate via RCR, some have linear ssDNA genomes with different replication methods, including the families
1745:"Evolution of eukaryotic single-stranded DNA viruses of the Bidnaviridae family from genes of four other groups of widely different viruses"
2514:
1833:
Eukaryotic circular rep-encoding single-stranded DNA (CRESS DNA) viruses: ubiquitous viruses with small genomes and a diverse host range
2571:
1848:
1611:
2576:
2499:
2487:
525:, a type of self-replicating genomic DNA molecule, which replaced the HUH endonuclease with a polinton's DNA polymerase.
6547:
346:
Rep may nick the positive strand a second time, doing so with a second tyrosine residue, or a new Rep may nick the DNA.
187:
that encode the HUH endonuclease. Eukaryotic viruses in the realm appear to have come into existence multiple times via
51:
4439:
390:
433:
share a number of other common characteristics. The capsids of ssDNA viruses, which store the viral DNA, are usually
6514:
6183:
5688:
4762:
126:
445:
Nearly all families of ssDNA viruses have a positive-sense genome, the sole exception being viruses in the family
1636:"Multiple Origins of Prokaryotic and Eukaryotic Single-Stranded DNA Viruses From Bacterial and Archaeal Plasmids"
1338:
1196:
are associated with many diseases, including respiratory illness, intestinal illness, and reproductive problems.
328:
1190:
infect economically important crops, causing significant damage to agricultural productivity. Animal viruses in
1131:
are assigned to
Baltimore Group I: dsDNA viruses. Realms are the highest level of taxonomy used for viruses and
2662:
2504:
1253:
1099:
1289:
2593:
452:
6462:
1178:
The eukaryotic CRESS-DNA viruses are associated with a variety of diseases. Plant viruses in the families
1309:
in 2019 based on their shared relation, including viruses descended from them. Despite appearing to have
6542:
6537:
2148:
1220:
463:
192:
188:
4950:
5424:
965:
6001:
5523:
4718:
2997:
2666:
2603:
2003:
1756:
1647:
506:
46:
5820:
5488:
5431:
5403:
5375:
5045:
4729:
4660:
3920:
3913:
3004:
2962:
2955:
1406:
Koonin EV, Dolja VV, Krupovic M, Varsani A, Wolf YI, Yutin N, Zerbini M, Kuhn JH (18 October 2019).
619:
611:
6015:
5869:
5648:
5396:
5389:
4209:
3407:
3025:
3011:
2969:
2882:
2178:
929:
300:
6107:
6058:
6008:
5987:
5438:
2948:
1301:
becoming the first ssDNA family recognized with additional families being continually discovered.
991:
983:
973:
921:
885:
5827:
4900:
4893:
3966:
3601:
3587:
3179:
2472:
2394:
1862:
1284:
1098:
includes the vast majority of identified ssDNA viruses, which are Group II: ssDNA viruses in the
660:
494:
466:. CRESS-DNA viruses also have similar genome structures, genome lengths, and gene compositions.
6500:
6123:
5082:
4957:
4936:
4829:
4485:
4143:
3785:
3348:
2941:
2868:
2450:
2366:
2268:
2038:
1992:
1854:
1844:
1782:
1673:
1607:
1551:
1475:
1212:
859:
696:, which encode an endonuclease containing an endonuclease domain, or a derivative of one, at
5913:
5841:
5734:
5309:
5251:
5214:
4943:
4674:
4632:
4580:
4543:
4513:
4474:
4328:
4254:
4111:
3433:
3396:
3370:
3328:
3129:
3119:
2934:
2786:
2757:
1982:
1974:
1836:
1772:
1764:
1663:
1655:
1541:
1533:
1465:
1457:
1408:"Create a megataxonomic framework, filling all principal taxonomic ranks, for ssDNA viruses"
1064:
1003:
835:
793:
785:
714:
106:
401:
Additionally, some viruses in the realm are dsDNA viruses with circular genomes, including
6373:
6244:
6079:
6027:
5940:
5896:
5885:
5723:
5575:
5516:
5340:
5061:
4991:
4879:
4862:
4797:
4394:
4349:
4070:
3577:
3359:
3270:
3190:
3086:
2310:
1270:
1197:
1113:
1080:
805:
759:
439:
418:
414:
351:
333:
564:
are monotypic down to the rank of family. This taxonomy is described further as follows:
315:
residues separated by a bulky hydrophobic residue and a Y motif that contains one or two
1760:
1651:
485:
Comparison of genomes and phylogenetic analyses of the HUH endonucleases, superfamily 3
6416:
6394:
6362:
6327:
6233:
6198:
6134:
5977:
5966:
5929:
5771:
5655:
5545:
5474:
5464:
5225:
5017:
4980:
4886:
4681:
4265:
4238:
3885:
3874:
3778:
3743:
3736:
3722:
3715:
3664:
3636:
3566:
3555:
3520:
3304:
3107:
2976:
2913:
2847:
2825:
2747:
2359:
2324:
2317:
2296:
2275:
2252:
2132:
1987:
1962:
1777:
1744:
1668:
1635:
1546:
1521:
1470:
1445:
1330:
1048:
1011:
955:
775:
587:
579:
470:
323:
308:
304:
243:
208:
1978:
1444:
Chandler M, de la Cruz F, Dyda F, Hickman AB, Moncalian G, Ton-Hoang B (August 2013).
6531:
6384:
6279:
6265:
6093:
6086:
6065:
5906:
5855:
5848:
5712:
5608:
5586:
5559:
5535:
5495:
5452:
5417:
5410:
5382:
5368:
5361:
5262:
5198:
5169:
5148:
5127:
5116:
5096:
5028:
4850:
4819:
4808:
4786:
4653:
4520:
4506:
4496:
4463:
4387:
4339:
4282:
4275:
4122:
4022:
3896:
3810:
3792:
3771:
3757:
3657:
3594:
3544:
3466:
3444:
3417:
3380:
3282:
3249:
3097:
3075:
2875:
2858:
2836:
2814:
2736:
2725:
2598:
2558:
2526:
2419:
2387:
2373:
2352:
2338:
2289:
2282:
2201:
2074:
1216:
1180:
1137:
1072:
1027:
1019:
843:
767:
723:
640:
595:
509:, whereby organisms that are not directly related evolve the same or similar traits.
456:
447:
381:
322:
Once the viral ssDNA is inside of the host cell, it is replicated by the host cell's
1866:
712:, that are descended from CRESS-DNA viruses, assigned to the kingdom's other phylum
6406:
6351:
6286:
6255:
6222:
6072:
6044:
5862:
5834:
5813:
5799:
5792:
5782:
5618:
5552:
5481:
5329:
5299:
5288:
5235:
5191:
5181:
5162:
5138:
5089:
5001:
4914:
4872:
4711:
4643:
4621:
4601:
4591:
4401:
4317:
4228:
4199:
4187:
4177:
4165:
4155:
4133:
4091:
4081:
4054:
4033:
4011:
3987:
3977:
3955:
3803:
3764:
3750:
3729:
3498:
3476:
3454:
3321:
3223:
3211:
3168:
3157:
3064:
3018:
2924:
2776:
2631:
2615:
2548:
2412:
2380:
2345:
2331:
2303:
2229:
1407:
1192:
1149:
1123:
1056:
947:
913:
903:
895:
877:
869:
851:
821:
813:
747:
731:
692:
676:
668:
652:
375:
369:
292:
250:
from deoxyribonucleic acid (DNA), referencing single-stranded DNA, and the suffix -
212:
156:
118:
38:
30:
1305:
CRESS-DNA viruses was resolved from 2015 to 2017, leading to the establishment of
6485:
1840:
708:
notably includes linear ssDNA and circular dsDNA viruses, assigned to its phylum
6494:
6272:
6051:
6037:
5950:
5806:
5596:
5509:
5502:
5445:
5351:
5272:
5155:
5072:
5038:
4964:
4926:
4907:
4843:
4836:
4667:
4527:
4216:
4044:
3944:
3839:
3689:
3671:
3647:
3510:
3488:
3314:
3292:
3260:
3201:
2990:
2902:
2764:
2714:
2690:
2477:
2222:
1205:
1186:
937:
739:
635:
469:
Lastly, ssDNA viruses have a relatively high rate of genetic recombinations and
434:
235:
144:
1659:
1537:
6144:
6100:
5994:
5755:
4564:
4554:
4306:
3906:
3233:
2983:
2608:
2555:
2142:
2055:
1835:. Advances in virus research. Vol. 103. Academic Press. pp. 71–133.
1358:
1320:
1280:
1275:
1043:
701:
697:
603:
347:
176:
appear to have come into existence independently multiple times from circular
161:
150:
6340:
6211:
5745:
5701:
4775:
4452:
4424:
3863:
2703:
2675:
2215:
2194:
2096:
1446:"Breaking and Joining Single-Stranded DNA: The HUH Endonuclease Superfamily"
1310:
1245:
1241:
1143:
570:
460:
394:
312:
196:
169:
138:
114:
1858:
1786:
1677:
1555:
1479:
1293:, was detailed. Beginning in the 1970s, the families of related members in
1996:
1223:, and papillomaviruses cause various genital and other cancers as well as
6479:
2588:
2533:
2120:
2104:
2069:
522:
486:
340:
316:
177:
1461:
2620:
2538:
2519:
2079:
2064:
1236:
307:
chain. HUH, or HuH, endonucleases are endonucleases that contain a HUH
254:, which is the suffix used for virus realms. The prototypic members of
195:(DNA) from the aforementioned plasmids with capsid proteins of certain
184:
181:
122:
1768:
1324:
2566:
2509:
2494:
2444:
2174:
1201:
296:
258:
are often called CRESS-DNA, or CRESS DNA, viruses, which stands for "
216:
6456:
1691:
1576:
429:
Apart from the aforementioned replication methods, ssDNA viruses in
1906:
1880:
1717:
1279:
plants that was likely caused by a geminivirus. Centuries later, a
2543:
2170:
2114:
2109:
1248:
enzymes or by exploiting the host cell's recombination machinery.
647:
may also be a unifying trait since it appears to be monophyletic.
110:
63:
1932:
2482:
2086:
2034:
1224:
1160:
is currently unassigned to a realm, it is a potential member of
6460:
6324:
6195:
5685:
4759:
4436:
3836:
2687:
2635:
2007:
1805:
1634:
Kazlauskas D, Varsani A, Koonin EV, Krupovic M (31 July 2019).
1287:
in 1974, and in 1977, the first genome of an ssDNA virus, the
1240:
Endogenization can occur through several means such as the
172:
and include the atypical members of the realm. Viruses in
1831:
Zhao, L.; Rosario, K.; Breitbart, M.; Duffy, S. (2019).
1204:, are thought to have a significant role in controlling
1273:, describing a yellowing or vein clearing disease of
512:
Linear ssDNA viruses, specifically parvoviruses, in
413:. Instead of replicating via RCR, these viruses use
136:
was established in 2019 and contains four kingdoms:
6469:
6404:
6382:
6371:
6360:
6349:
6338:
6253:
6242:
6231:
6220:
6209:
6182:
6132:
6121:
6025:
5975:
5964:
5938:
5927:
5894:
5883:
5780:
5769:
5743:
5732:
5721:
5710:
5699:
5636:
5606:
5584:
5573:
5533:
5462:
5349:
5338:
5327:
5297:
5286:
5260:
5249:
5223:
5212:
5179:
5136:
5125:
5114:
5070:
5059:
5026:
5015:
4989:
4978:
4924:
4860:
4817:
4806:
4795:
4784:
4773:
4699:
4641:
4630:
4619:
4589:
4578:
4552:
4541:
4494:
4483:
4472:
4461:
4450:
4423:
4375:
4337:
4326:
4315:
4304:
4263:
4252:
4226:
4197:
4175:
4153:
4131:
4120:
4109:
4079:
4068:
4042:
4031:
4020:
4009:
3975:
3964:
3953:
3942:
3894:
3883:
3872:
3861:
3850:
3703:
3681:
3645:
3634:
3627:
3575:
3564:
3553:
3542:
3508:
3486:
3464:
3442:
3431:
3405:
3394:
3368:
3357:
3346:
3302:
3280:
3258:
3247:
3221:
3199:
3188:
3177:
3166:
3155:
3117:
3095:
3084:
3073:
3062:
3051:
2922:
2911:
2900:
2856:
2845:
2834:
2823:
2812:
2774:
2745:
2734:
2723:
2712:
2701:
2674:
2463:
2437:
2404:
2260:
2246:
2239:
2186:
2169:
2162:
2130:
2095:
2053:
2046:
339:The 3'-end of the nicked strand remains as a free
1812:. International Committee on Taxonomy of Viruses
1602:Kerr J, Cotmore S, Bloom ME (25 November 2005).
1963:"Progress towards a higher taxonomy of viruses"
291:encode an endonuclease of the HUH superfamily.
1415:International Committee on Taxonomy of Viruses
1269:was made in a poem written in 752 by Japanese
698:the start of the protein's amino acid sequence
2647:
2019:
1718:"Viral replication/transcription/translation"
1522:"ssDNA Viruses: Key Players in Global Virome"
1047:, which only infect archaea and which have a
459:(mRNA) needed to produce viral proteins from
336:molecule that connects Rep to the viral DNA.
160:. Viruses in the first three kingdoms infect
8:
1629:
1627:
1625:
1623:
702:the end of the protein's amino acid sequence
556:is monotypic down to the rank of order, and
2582:Reverse transcriptase-related cellular gene
1401:
1399:
1397:
1357:The only exception to this is that certain
6457:
6379:
6368:
6357:
6346:
6335:
6321:
6250:
6239:
6228:
6217:
6206:
6192:
6188:
6129:
5972:
5935:
5891:
5777:
5740:
5729:
5718:
5707:
5696:
5682:
5581:
5346:
5335:
5294:
5257:
5220:
5133:
5122:
5067:
5023:
4986:
4814:
4803:
4792:
4781:
4770:
4756:
4638:
4627:
4586:
4549:
4491:
4480:
4469:
4458:
4447:
4433:
4429:
4334:
4323:
4312:
4260:
4128:
4117:
4076:
4039:
4028:
4017:
3972:
3961:
3950:
3891:
3880:
3869:
3858:
3847:
3833:
3642:
3631:
3572:
3561:
3550:
3439:
3402:
3365:
3354:
3255:
3196:
3185:
3174:
3163:
3092:
3081:
3070:
3059:
2919:
2908:
2853:
2842:
2831:
2820:
2742:
2731:
2720:
2709:
2698:
2684:
2680:
2654:
2640:
2632:
2243:
2183:
2166:
2050:
2026:
2012:
2004:
1515:
1513:
1511:
1509:
1439:
1437:
1435:
1433:
1431:
1395:
1393:
1391:
1389:
1387:
1385:
1383:
1381:
1379:
1377:
1257:genomes at least 40–50 million years ago.
199:. Most identified ssDNA viruses belong to
29:
18:
1986:
1776:
1667:
1545:
1507:
1505:
1503:
1501:
1499:
1497:
1495:
1493:
1491:
1489:
1469:
1107:, all three being unassigned to a realm:
489:(S3H), and capsid proteins of viruses in
1520:Malathi VG, Renuka Devi P (March 2019).
1051:that contains a membrane fusion protein
2563:Retroelements not elsewhere classified
1800:
1798:
1796:
1571:
1569:
1567:
1565:
1373:
1350:
700:and a superfamily 3 helicase domain at
393:, in which the ends of the genome have
1743:Krupvoic M, Koonin EV (18 June 2014).
1135:is one of four, the other three being
1265:The earliest reference to a virus in
7:
493:have shown that they have multiple,
2515:Integrative and conjugative element
1939:. Swiss Institute of Bioinformatics
1913:. Swiss Institute of Bioinformatics
1887:. Swiss Institute of Bioinformatics
1724:. Swiss Institute of Bioinformatics
1698:. Swiss Institute of Bioinformatics
1583:. Swiss Institute of Bioinformatics
1361:do not encode the HUH endonuclease.
215:, which are known to cause various
123:endonuclease of the HUH superfamily
91:
363:While the prototypical viruses in
283:Endonuclease-initiated replication
14:
2572:Diversity-generating retroelement
1692:"dsDNA bidirectional replication"
1117:, a proposed member of the realm
2577:Telomerase reverse transcriptase
2149:Microbes with highly unusual DNA
1323:
50:
1606:. CRC Press. pp. 171–185.
2500:Defective interfering particle
1806:"Virus Taxonomy: 2019 Release"
409:, also assigned to the phylum
1:
2488:Clonally transmissible cancer
1979:10.1016/S0923-2516(06)80059-2
348:Multiple copies of the genome
1841:10.1016/bs.aivir.2018.10.001
287:All prototypical viruses in
2041:, and comparable structures
442:in their folded structure.
391:rolling hairpin replication
355:the original viral genome.
115:single-stranded DNA viruses
6564:
1660:10.1038/s41467-019-11433-0
1538:10.1007/s13337-019-00519-4
127:rolling circle replication
6334:
6320:
6205:
6191:
5695:
5681:
4769:
4755:
4446:
4432:
3846:
3832:
2697:
2683:
1339:List of higher virus taxa
1200:, which primarily infect
379:, assigned to the phylum
89:
84:
45:
37:
28:
21:
2505:Endogenous viral element
1290:Bean golden mosaic virus
1254:horizontal gene transfer
1100:Baltimore classification
246:μόνος , meaning single,
1297:began to be organized,
1169:Interactions with hosts
1127:. The dsDNA viruses in
1577:"ssDNA Rolling circle"
1235:The Rep protein lacks
643:. The endonuclease of
471:substitution mutations
1221:Merkel-cell carcinoma
425:Other characteristics
193:deoxyribonucleic acid
189:genetic recombination
2667:virus classification
2604:Transposable element
2594:Spiegelman's Monster
1967:Research in Virology
1961:Ward, C. W. (1993).
507:convergent evolution
455:, which creates the
301:phosphodiester bonds
47:Virus classification
6548:Polyphyletic groups
5649:Permutotetraviridae
3408:Orthopolintovirales
2883:Malacoherpesviridae
1810:talk.ictvonline.org
1761:2014NatSR...4E5347K
1652:2019NatCo..10.3425K
1462:10.1038/nrmicro3067
1215:as well as causing
536:has four kingdoms:
389:. Parvoviruses use
191:events that merged
3967:Malgrandaviricetes
3602:Sphaerolipoviridae
3588:Matshushitaviridae
3180:Nucleocytoviricota
2473:Bio-like structure
2395:Tolecusatellitidae
1933:"Papillomaviridae"
1285:porcine circovirus
661:Malgrandaviricetes
113:that includes all
6525:
6524:
6463:Taxon identifiers
6454:
6453:
6450:
6449:
6446:
6445:
6442:
6441:
6438:
6437:
6434:
6433:
6430:
6429:
6426:
6425:
6316:
6315:
6312:
6311:
6308:
6307:
6304:
6303:
6300:
6299:
6296:
6295:
6178:
6177:
6174:
6173:
6170:
6169:
6166:
6165:
6162:
6161:
6158:
6157:
6154:
6153:
6124:Yunchangviricetes
6117:
6116:
5960:
5959:
5923:
5922:
5879:
5878:
5765:
5764:
5677:
5676:
5673:
5672:
5669:
5668:
5665:
5664:
5632:
5631:
5628:
5627:
5569:
5568:
5323:
5322:
5319:
5318:
5282:
5281:
5245:
5244:
5208:
5207:
5110:
5109:
5106:
5105:
5083:Carmotetraviridae
5055:
5054:
5011:
5010:
4974:
4973:
4958:Gammaflexiviridae
4951:Deltaflexiviridae
4937:Alphaflexiviridae
4830:Alphatetraviridae
4751:
4750:
4747:
4746:
4743:
4742:
4739:
4738:
4695:
4694:
4691:
4690:
4615:
4614:
4611:
4610:
4574:
4573:
4537:
4536:
4486:Chrymotiviricetes
4419:
4418:
4415:
4414:
4411:
4410:
4371:
4370:
4367:
4366:
4363:
4362:
4359:
4358:
4300:
4299:
4296:
4295:
4292:
4291:
4248:
4247:
4144:Bacilladnaviridae
4105:
4104:
4101:
4100:
4064:
4063:
4005:
4004:
4001:
4000:
3997:
3996:
3938:
3937:
3934:
3933:
3930:
3929:
3828:
3827:
3824:
3823:
3820:
3819:
3786:Portogloboviridae
3699:
3698:
3623:
3622:
3619:
3618:
3615:
3614:
3611:
3610:
3538:
3537:
3534:
3533:
3530:
3529:
3427:
3426:
3390:
3389:
3349:Preplasmiviricota
3342:
3341:
3338:
3337:
3243:
3242:
3151:
3150:
3147:
3146:
3143:
3142:
3139:
3138:
3047:
3046:
3043:
3042:
3039:
3038:
3035:
3034:
2942:Autographiviridae
2896:
2895:
2892:
2891:
2869:Alloherpesviridae
2808:
2807:
2804:
2803:
2800:
2799:
2796:
2795:
2629:
2628:
2459:
2458:
2433:
2432:
2429:
2428:
2367:Portogloboviridae
2269:Alphasatellitidae
2163:Non-cellular life
2158:
2157:
2039:non-cellular life
1769:10.1038/srep05347
1450:Nat Rev Microbiol
1198:Bacilladnaviruses
860:Bacilladnaviridae
164:, and viruses in
98:
97:
6555:
6518:
6517:
6505:
6504:
6503:
6490:
6489:
6488:
6458:
6380:
6369:
6358:
6347:
6336:
6328:dsDNA-RT viruses
6322:
6251:
6240:
6229:
6218:
6207:
6199:ssRNA-RT viruses
6193:
6189:
6130:
5973:
5941:Serpentovirales
5936:
5914:Orthomyxoviridae
5892:
5842:Peribunyaviridae
5778:
5741:
5735:Chunqiuviricetes
5730:
5719:
5708:
5697:
5689:(–)ssRNA viruses
5683:
5582:
5425:Nanghoshaviridae
5347:
5336:
5310:Botourmiaviridae
5295:
5258:
5252:Howeltoviricetes
5221:
5215:Amabiliviricetes
5134:
5123:
5068:
5024:
4987:
4944:Betaflexiviridae
4815:
4804:
4793:
4782:
4771:
4763:(+)ssRNA viruses
4757:
4675:Picobirnaviridae
4639:
4633:Duplopiviricetes
4628:
4587:
4581:Vidaverviricetes
4550:
4544:Resentoviricetes
4514:Megabirnaviridae
4492:
4481:
4475:Duplornaviricota
4470:
4459:
4448:
4434:
4430:
4335:
4329:Huolimaviricetes
4324:
4313:
4261:
4255:Repensiviricetes
4129:
4118:
4112:Cressdnaviricota
4077:
4040:
4029:
4018:
3973:
3962:
3951:
3892:
3881:
3870:
3859:
3848:
3834:
3643:
3632:
3573:
3562:
3551:
3440:
3434:Tectiliviricetes
3403:
3397:Polintoviricetes
3371:Priklausovirales
3366:
3355:
3329:Marseilleviridae
3256:
3197:
3186:
3175:
3164:
3130:Papillomaviridae
3120:Zurhausenvirales
3093:
3082:
3071:
3060:
2935:Ackermannviridae
2920:
2909:
2854:
2843:
2832:
2821:
2787:Tristromaviridae
2758:Lipothrixviridae
2743:
2732:
2721:
2710:
2699:
2685:
2681:
2656:
2649:
2642:
2633:
2244:
2184:
2167:
2051:
2028:
2021:
2014:
2005:
2000:
1990:
1949:
1948:
1946:
1944:
1929:
1923:
1922:
1920:
1918:
1907:"Polyomaviridae"
1903:
1897:
1896:
1894:
1892:
1877:
1871:
1870:
1828:
1822:
1821:
1819:
1817:
1802:
1791:
1790:
1780:
1740:
1734:
1733:
1731:
1729:
1714:
1708:
1707:
1705:
1703:
1688:
1682:
1681:
1671:
1631:
1618:
1617:
1599:
1593:
1592:
1590:
1588:
1573:
1560:
1559:
1549:
1517:
1484:
1483:
1473:
1441:
1426:
1425:
1423:
1421:
1412:
1403:
1362:
1355:
1333:
1328:
1327:
1065:Huolimaviricetes
1004:Repensiviricetes
966:Rivendellvirales
836:Cressdnaviricota
794:Papillomaviridae
786:Zurhausenvirales
715:Cressdnaviricota
407:Papillomaviridae
359:Atypical members
299:that can cleave
209:papillomaviruses
55:
54:
33:
19:
16:Realm of viruses
6563:
6562:
6558:
6557:
6556:
6554:
6553:
6552:
6528:
6527:
6526:
6521:
6513:
6508:
6499:
6498:
6493:
6484:
6483:
6478:
6465:
6455:
6422:
6400:
6374:Revtraviricetes
6330:
6292:
6245:Revtraviricetes
6201:
6150:
6113:
6080:Paramyxoviridae
6028:Mononegavirales
6021:
6002:Crepuscuviridae
5956:
5919:
5897:Articulavirales
5886:Insthoviricetes
5875:
5761:
5724:Negarnaviricota
5691:
5661:
5624:
5602:
5576:Stelpaviricetes
5565:
5529:
5524:Polycipiviridae
5517:Dicistroviridae
5458:
5341:Pisoniviricetes
5315:
5278:
5241:
5204:
5175:
5102:
5062:Tolucaviricetes
5051:
5007:
4992:Amarillovirales
4970:
4920:
4880:Closteroviridae
4863:Martellivirales
4856:
4798:Kitrinoviricota
4765:
4735:
4719:Polymycoviridae
4687:
4607:
4570:
4533:
4442:
4407:
4395:Finnlakeviridae
4355:
4350:Pleolipoviridae
4288:
4244:
4222:
4193:
4171:
4149:
4097:
4071:Quintoviricetes
4060:
3993:
3926:
3842:
3816:
3695:
3677:
3607:
3578:Halopanivirales
3526:
3504:
3482:
3460:
3423:
3386:
3360:Maveriviricetes
3334:
3298:
3276:
3271:Phycodnaviridae
3239:
3217:
3191:Pokkesviricetes
3135:
3113:
3087:Papovaviricetes
3031:
2998:Rountreeviridae
2888:
2792:
2770:
2693:
2670:
2660:
2630:
2625:
2465:
2455:
2425:
2400:
2311:Finnlakeviridae
2256:
2235:
2177:
2173:
2154:
2126:
2091:
2042:
2032:
1960:
1957:
1955:Further reading
1952:
1942:
1940:
1931:
1930:
1926:
1916:
1914:
1905:
1904:
1900:
1890:
1888:
1879:
1878:
1874:
1851:
1830:
1829:
1825:
1815:
1813:
1804:
1803:
1794:
1742:
1741:
1737:
1727:
1725:
1716:
1715:
1711:
1701:
1699:
1690:
1689:
1685:
1633:
1632:
1621:
1614:
1601:
1600:
1596:
1586:
1584:
1575:
1574:
1563:
1519:
1518:
1487:
1443:
1442:
1429:
1419:
1417:
1410:
1405:
1404:
1375:
1371:
1366:
1365:
1356:
1352:
1347:
1329:
1322:
1319:
1271:Empress Shotoku
1263:
1233:
1176:
1171:
1114:Finnlakeviridae
1081:Pleolipoviridae
806:Quintoviricetes
760:Papovaviricetes
531:
483:
440:jelly roll fold
427:
419:DNA replication
385:of the kingdom
361:
352:phosphotyrosine
334:phosphotyrosine
285:
280:
278:Characteristics
229:
125:that initiates
49:
17:
12:
11:
5:
6561:
6559:
6551:
6550:
6545:
6540:
6530:
6529:
6523:
6522:
6520:
6519:
6506:
6491:
6475:
6473:
6467:
6466:
6461:
6452:
6451:
6448:
6447:
6444:
6443:
6440:
6439:
6436:
6435:
6432:
6431:
6428:
6427:
6424:
6423:
6421:
6420:
6417:Caulimoviridae
6412:
6410:
6402:
6401:
6399:
6398:
6395:Hepadnaviridae
6390:
6388:
6377:
6366:
6363:Artverviricota
6355:
6344:
6332:
6331:
6325:
6318:
6317:
6314:
6313:
6310:
6309:
6306:
6305:
6302:
6301:
6298:
6297:
6294:
6293:
6291:
6290:
6283:
6276:
6269:
6261:
6259:
6248:
6237:
6234:Artverviricota
6226:
6215:
6203:
6202:
6196:
6186:
6180:
6179:
6176:
6175:
6172:
6171:
6168:
6167:
6164:
6163:
6160:
6159:
6156:
6155:
6152:
6151:
6149:
6148:
6140:
6138:
6135:Goujianvirales
6127:
6119:
6118:
6115:
6114:
6112:
6111:
6104:
6097:
6090:
6083:
6076:
6069:
6062:
6055:
6048:
6041:
6033:
6031:
6023:
6022:
6020:
6019:
6012:
6005:
5998:
5991:
5983:
5981:
5978:Jingchuvirales
5970:
5967:Monjiviricetes
5962:
5961:
5958:
5957:
5955:
5954:
5946:
5944:
5933:
5930:Milneviricetes
5925:
5924:
5921:
5920:
5918:
5917:
5910:
5902:
5900:
5889:
5881:
5880:
5877:
5876:
5874:
5873:
5866:
5859:
5852:
5845:
5838:
5831:
5824:
5821:Leishbuviridae
5817:
5810:
5803:
5796:
5788:
5786:
5775:
5772:Ellioviricetes
5767:
5766:
5763:
5762:
5760:
5759:
5751:
5749:
5738:
5727:
5716:
5705:
5693:
5692:
5686:
5679:
5678:
5675:
5674:
5671:
5670:
5667:
5666:
5663:
5662:
5660:
5659:
5656:Sarthroviridae
5652:
5640:
5638:
5634:
5633:
5630:
5629:
5626:
5625:
5623:
5622:
5614:
5612:
5604:
5603:
5601:
5600:
5592:
5590:
5579:
5571:
5570:
5567:
5566:
5564:
5563:
5556:
5549:
5546:Alvernaviridae
5541:
5539:
5531:
5530:
5528:
5527:
5520:
5513:
5506:
5499:
5492:
5489:Solinviviridae
5485:
5478:
5475:Picornaviridae
5470:
5468:
5465:Picornavirales
5460:
5459:
5457:
5456:
5449:
5442:
5435:
5432:Nanhypoviridae
5428:
5421:
5414:
5407:
5404:Medioniviridae
5400:
5393:
5386:
5379:
5376:Cremegaviridae
5372:
5365:
5357:
5355:
5344:
5333:
5325:
5324:
5321:
5320:
5317:
5316:
5314:
5313:
5305:
5303:
5292:
5284:
5283:
5280:
5279:
5277:
5276:
5268:
5266:
5255:
5247:
5246:
5243:
5242:
5240:
5239:
5231:
5229:
5226:Wolframvirales
5218:
5210:
5209:
5206:
5205:
5203:
5202:
5195:
5187:
5185:
5177:
5176:
5174:
5173:
5166:
5159:
5152:
5144:
5142:
5131:
5120:
5112:
5111:
5108:
5107:
5104:
5103:
5101:
5100:
5093:
5086:
5078:
5076:
5065:
5057:
5056:
5053:
5052:
5050:
5049:
5046:Sinhaliviridae
5042:
5034:
5032:
5021:
5018:Magsaviricetes
5013:
5012:
5009:
5008:
5006:
5005:
4997:
4995:
4984:
4981:Flasuviricetes
4976:
4975:
4972:
4971:
4969:
4968:
4961:
4954:
4947:
4940:
4932:
4930:
4922:
4921:
4919:
4918:
4911:
4904:
4897:
4890:
4887:Endornaviridae
4883:
4876:
4868:
4866:
4858:
4857:
4855:
4854:
4847:
4840:
4833:
4825:
4823:
4812:
4801:
4790:
4779:
4767:
4766:
4760:
4753:
4752:
4749:
4748:
4745:
4744:
4741:
4740:
4737:
4736:
4734:
4733:
4730:Botybirnavirus
4722:
4715:
4703:
4701:
4697:
4696:
4693:
4692:
4689:
4688:
4686:
4685:
4682:Partitiviridae
4678:
4671:
4664:
4661:Curvulaviridae
4657:
4649:
4647:
4636:
4625:
4617:
4616:
4613:
4612:
4609:
4608:
4606:
4605:
4597:
4595:
4584:
4576:
4575:
4572:
4571:
4569:
4568:
4560:
4558:
4547:
4539:
4538:
4535:
4534:
4532:
4531:
4524:
4517:
4510:
4502:
4500:
4489:
4478:
4467:
4456:
4444:
4443:
4437:
4427:
4421:
4420:
4417:
4416:
4413:
4412:
4409:
4408:
4406:
4405:
4398:
4391:
4379:
4377:
4373:
4372:
4369:
4368:
4365:
4364:
4361:
4360:
4357:
4356:
4354:
4353:
4345:
4343:
4332:
4321:
4310:
4302:
4301:
4298:
4297:
4294:
4293:
4290:
4289:
4287:
4286:
4279:
4271:
4269:
4266:Geplafuvirales
4258:
4250:
4249:
4246:
4245:
4243:
4242:
4239:Redondoviridae
4234:
4232:
4224:
4223:
4221:
4220:
4213:
4205:
4203:
4195:
4194:
4192:
4191:
4183:
4181:
4173:
4172:
4170:
4169:
4161:
4159:
4151:
4150:
4148:
4147:
4139:
4137:
4126:
4115:
4107:
4106:
4103:
4102:
4099:
4098:
4096:
4095:
4087:
4085:
4074:
4066:
4065:
4062:
4061:
4059:
4058:
4050:
4048:
4037:
4026:
4015:
4007:
4006:
4003:
4002:
3999:
3998:
3995:
3994:
3992:
3991:
3983:
3981:
3970:
3959:
3948:
3940:
3939:
3936:
3935:
3932:
3931:
3928:
3927:
3925:
3924:
3921:Plectroviridae
3917:
3914:Paulinoviridae
3910:
3902:
3900:
3889:
3886:Faserviricetes
3878:
3875:Hofneiviricota
3867:
3856:
3844:
3843:
3837:
3830:
3829:
3826:
3825:
3822:
3821:
3818:
3817:
3815:
3814:
3807:
3796:
3789:
3782:
3779:Polydnaviridae
3775:
3768:
3761:
3754:
3747:
3744:Globuloviridae
3740:
3737:Fuselloviridae
3733:
3726:
3723:Bicaudaviridae
3719:
3716:Ampullaviridae
3707:
3705:
3701:
3700:
3697:
3696:
3694:
3693:
3685:
3683:
3679:
3678:
3676:
3675:
3668:
3665:Hytrosaviridae
3661:
3653:
3651:
3640:
3637:Naldaviricetes
3629:
3625:
3624:
3621:
3620:
3617:
3616:
3613:
3612:
3609:
3608:
3606:
3605:
3598:
3591:
3583:
3581:
3570:
3567:Laserviricetes
3559:
3556:Dividoviricota
3548:
3540:
3539:
3536:
3535:
3532:
3531:
3528:
3527:
3525:
3524:
3521:Corticoviridae
3516:
3514:
3506:
3505:
3503:
3502:
3494:
3492:
3484:
3483:
3481:
3480:
3472:
3470:
3462:
3461:
3459:
3458:
3450:
3448:
3437:
3429:
3428:
3425:
3424:
3422:
3421:
3413:
3411:
3400:
3392:
3391:
3388:
3387:
3385:
3384:
3376:
3374:
3363:
3352:
3344:
3343:
3340:
3339:
3336:
3335:
3333:
3332:
3325:
3318:
3310:
3308:
3305:Pimascovirales
3300:
3299:
3297:
3296:
3288:
3286:
3278:
3277:
3275:
3274:
3266:
3264:
3253:
3245:
3244:
3241:
3240:
3238:
3237:
3229:
3227:
3219:
3218:
3216:
3215:
3207:
3205:
3194:
3183:
3172:
3161:
3153:
3152:
3149:
3148:
3145:
3144:
3141:
3140:
3137:
3136:
3134:
3133:
3125:
3123:
3115:
3114:
3112:
3111:
3108:Polyomaviridae
3103:
3101:
3090:
3079:
3068:
3057:
3049:
3048:
3045:
3044:
3041:
3040:
3037:
3036:
3033:
3032:
3030:
3029:
3022:
3015:
3008:
3005:Salasmaviridae
3001:
2994:
2987:
2980:
2977:Herelleviridae
2973:
2966:
2963:Drexlerviridae
2959:
2956:Demerecviridae
2952:
2945:
2938:
2930:
2928:
2917:
2914:Caudoviricetes
2906:
2898:
2897:
2894:
2893:
2890:
2889:
2887:
2886:
2879:
2872:
2864:
2862:
2851:
2848:Herviviricetes
2840:
2829:
2826:Heunggongvirae
2818:
2810:
2809:
2806:
2805:
2802:
2801:
2798:
2797:
2794:
2793:
2791:
2790:
2782:
2780:
2772:
2771:
2769:
2768:
2761:
2753:
2751:
2748:Ligamenvirales
2740:
2729:
2718:
2707:
2695:
2694:
2688:
2678:
2672:
2671:
2661:
2659:
2658:
2651:
2644:
2636:
2627:
2626:
2624:
2623:
2618:
2613:
2612:
2611:
2601:
2596:
2591:
2586:
2585:
2584:
2579:
2574:
2569:
2561:
2553:
2552:
2551:
2541:
2536:
2531:
2522:
2517:
2512:
2507:
2502:
2497:
2492:
2491:
2490:
2485:
2475:
2469:
2467:
2461:
2460:
2457:
2456:
2454:
2453:
2448:
2441:
2439:
2435:
2434:
2431:
2430:
2427:
2426:
2424:
2423:
2416:
2408:
2406:
2402:
2401:
2399:
2398:
2391:
2384:
2377:
2370:
2363:
2360:Polydnaviridae
2356:
2349:
2342:
2335:
2328:
2325:Globuloviridae
2321:
2318:Fuselloviridae
2314:
2307:
2300:
2297:Bicaudaviridae
2293:
2286:
2279:
2276:Ampullaviridae
2272:
2264:
2262:
2258:
2257:
2253:Naldaviricetes
2250:
2248:
2241:
2237:
2236:
2234:
2233:
2226:
2219:
2212:
2205:
2198:
2190:
2188:
2181:
2164:
2160:
2159:
2156:
2155:
2153:
2152:
2146:
2138:
2136:
2133:Incertae sedis
2128:
2127:
2125:
2124:
2117:
2112:
2107:
2101:
2099:
2093:
2092:
2090:
2089:
2084:
2083:
2082:
2077:
2067:
2061:
2059:
2048:
2044:
2043:
2033:
2031:
2030:
2023:
2016:
2008:
2002:
2001:
1956:
1953:
1951:
1950:
1924:
1898:
1881:"Parvoviridae"
1872:
1849:
1823:
1792:
1735:
1709:
1683:
1619:
1612:
1594:
1561:
1485:
1456:(8): 525–538.
1427:
1372:
1370:
1367:
1364:
1363:
1349:
1348:
1346:
1343:
1342:
1341:
1335:
1334:
1331:Viruses portal
1318:
1315:
1262:
1259:
1232:
1231:Endogenization
1229:
1175:
1172:
1170:
1167:
1093:
1092:
1091:
1090:
1089:
1088:
1087:
1086:
1085:
1084:
1049:viral envelope
1039:
1038:
1037:
1036:
1035:
1034:
1033:
1032:
1031:
1023:
1012:Geplafuvirales
999:
998:
997:
996:
995:
979:
978:
977:
961:
960:
959:
956:Redondoviridae
943:
942:
941:
933:
925:
909:
908:
907:
891:
890:
889:
881:
865:
864:
863:
831:
830:
829:
828:
827:
826:
825:
801:
800:
799:
798:
797:
781:
780:
779:
776:Polyomaviridae
755:
754:
753:
752:
751:
688:
687:
686:
685:
684:
683:
682:
681:
680:
631:
630:
629:
628:
627:
626:
625:
624:
623:
620:Plectroviridae
615:
612:Paulinoviridae
607:
588:Faserviricetes
580:Hofneiviricota
530:
529:Classification
527:
482:
479:
426:
423:
417:bidirectional
403:Polyomaviridae
360:
357:
329:positive-sense
324:DNA polymerase
305:polynucleotide
284:
281:
279:
276:
228:
225:
213:polyomaviruses
96:
95:
87:
86:
82:
81:
74:
67:
66:
61:
57:
56:
43:
42:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
6560:
6549:
6546:
6544:
6541:
6539:
6536:
6535:
6533:
6516:
6511:
6507:
6502:
6496:
6492:
6487:
6481:
6477:
6476:
6474:
6472:
6468:
6464:
6459:
6419:
6418:
6414:
6413:
6411:
6409:
6408:
6403:
6397:
6396:
6392:
6391:
6389:
6387:
6386:
6385:Blubervirales
6381:
6378:
6376:
6375:
6370:
6367:
6365:
6364:
6359:
6356:
6354:
6353:
6348:
6345:
6343:
6342:
6337:
6333:
6329:
6323:
6319:
6289:
6288:
6284:
6282:
6281:
6280:Pseudoviridae
6277:
6275:
6274:
6270:
6268:
6267:
6266:Belpaoviridae
6263:
6262:
6260:
6258:
6257:
6252:
6249:
6247:
6246:
6241:
6238:
6236:
6235:
6230:
6227:
6225:
6224:
6219:
6216:
6214:
6213:
6208:
6204:
6200:
6194:
6190:
6187:
6185:
6181:
6147:
6146:
6142:
6141:
6139:
6137:
6136:
6131:
6128:
6126:
6125:
6120:
6110:
6109:
6105:
6103:
6102:
6098:
6096:
6095:
6094:Rhabdoviridae
6091:
6089:
6088:
6087:Pneumoviridae
6084:
6082:
6081:
6077:
6075:
6074:
6070:
6068:
6067:
6066:Mymonaviridae
6063:
6061:
6060:
6056:
6054:
6053:
6049:
6047:
6046:
6042:
6040:
6039:
6035:
6034:
6032:
6030:
6029:
6024:
6018:
6017:
6016:Natareviridae
6013:
6011:
6010:
6006:
6004:
6003:
5999:
5997:
5996:
5992:
5990:
5989:
5985:
5984:
5982:
5980:
5979:
5974:
5971:
5969:
5968:
5963:
5953:
5952:
5948:
5947:
5945:
5943:
5942:
5937:
5934:
5932:
5931:
5926:
5916:
5915:
5911:
5909:
5908:
5907:Amnoonviridae
5904:
5903:
5901:
5899:
5898:
5893:
5890:
5888:
5887:
5882:
5872:
5871:
5870:Wupedeviridae
5867:
5865:
5864:
5860:
5858:
5857:
5856:Phenuiviridae
5853:
5851:
5850:
5849:Phasmaviridae
5846:
5844:
5843:
5839:
5837:
5836:
5832:
5830:
5829:
5825:
5823:
5822:
5818:
5816:
5815:
5811:
5809:
5808:
5804:
5802:
5801:
5797:
5795:
5794:
5790:
5789:
5787:
5785:
5784:
5779:
5776:
5774:
5773:
5768:
5758:
5757:
5753:
5752:
5750:
5748:
5747:
5742:
5739:
5737:
5736:
5731:
5728:
5726:
5725:
5720:
5717:
5715:
5714:
5713:Orthornavirae
5709:
5706:
5704:
5703:
5698:
5694:
5690:
5684:
5680:
5658:
5657:
5653:
5651:
5650:
5645:
5642:
5641:
5639:
5635:
5621:
5620:
5616:
5615:
5613:
5611:
5610:
5609:Stellavirales
5605:
5599:
5598:
5594:
5593:
5591:
5589:
5588:
5587:Patatavirales
5583:
5580:
5578:
5577:
5572:
5562:
5561:
5560:Solemoviridae
5557:
5555:
5554:
5550:
5548:
5547:
5543:
5542:
5540:
5538:
5537:
5536:Sobelivirales
5532:
5526:
5525:
5521:
5519:
5518:
5514:
5512:
5511:
5507:
5505:
5504:
5500:
5498:
5497:
5496:Caliciviridae
5493:
5491:
5490:
5486:
5484:
5483:
5479:
5477:
5476:
5472:
5471:
5469:
5467:
5466:
5461:
5455:
5454:
5453:Tobaniviridae
5450:
5448:
5447:
5443:
5441:
5440:
5436:
5434:
5433:
5429:
5427:
5426:
5422:
5420:
5419:
5418:Mononiviridae
5415:
5413:
5412:
5411:Mesoniviridae
5408:
5406:
5405:
5401:
5399:
5398:
5397:Gresnaviridae
5394:
5392:
5391:
5390:Euroniviridae
5387:
5385:
5384:
5383:Coronaviridae
5380:
5378:
5377:
5373:
5371:
5370:
5369:Arteriviridae
5366:
5364:
5363:
5362:Abyssoviridae
5359:
5358:
5356:
5354:
5353:
5348:
5345:
5343:
5342:
5337:
5334:
5332:
5331:
5326:
5312:
5311:
5307:
5306:
5304:
5302:
5301:
5296:
5293:
5291:
5290:
5285:
5275:
5274:
5270:
5269:
5267:
5265:
5264:
5263:Cryppavirales
5259:
5256:
5254:
5253:
5248:
5238:
5237:
5233:
5232:
5230:
5228:
5227:
5222:
5219:
5217:
5216:
5211:
5201:
5200:
5199:Steitzviridae
5196:
5194:
5193:
5189:
5188:
5186:
5184:
5183:
5178:
5172:
5171:
5170:Solspiviridae
5167:
5165:
5164:
5160:
5158:
5157:
5153:
5151:
5150:
5149:Atkinsviridae
5146:
5145:
5143:
5141:
5140:
5135:
5132:
5130:
5129:
5128:Leviviricetes
5124:
5121:
5119:
5118:
5117:Lenarviricota
5113:
5099:
5098:
5097:Tombusviridae
5094:
5092:
5091:
5087:
5085:
5084:
5080:
5079:
5077:
5075:
5074:
5069:
5066:
5064:
5063:
5058:
5048:
5047:
5043:
5041:
5040:
5036:
5035:
5033:
5031:
5030:
5029:Nodamuvirales
5025:
5022:
5020:
5019:
5014:
5004:
5003:
4999:
4998:
4996:
4994:
4993:
4988:
4985:
4983:
4982:
4977:
4967:
4966:
4962:
4960:
4959:
4955:
4953:
4952:
4948:
4946:
4945:
4941:
4939:
4938:
4934:
4933:
4931:
4929:
4928:
4923:
4917:
4916:
4912:
4910:
4909:
4905:
4903:
4902:
4898:
4896:
4895:
4891:
4889:
4888:
4884:
4882:
4881:
4877:
4875:
4874:
4870:
4869:
4867:
4865:
4864:
4859:
4853:
4852:
4851:Matonaviridae
4848:
4846:
4845:
4841:
4839:
4838:
4834:
4832:
4831:
4827:
4826:
4824:
4822:
4821:
4820:Hepelivirales
4816:
4813:
4811:
4810:
4809:Alsuviricetes
4805:
4802:
4800:
4799:
4794:
4791:
4789:
4788:
4787:Orthornavirae
4783:
4780:
4778:
4777:
4772:
4768:
4764:
4758:
4754:
4732:
4731:
4726:
4723:
4721:
4720:
4716:
4714:
4713:
4708:
4705:
4704:
4702:
4698:
4684:
4683:
4679:
4677:
4676:
4672:
4670:
4669:
4665:
4663:
4662:
4658:
4656:
4655:
4654:Amalgaviridae
4651:
4650:
4648:
4646:
4645:
4640:
4637:
4635:
4634:
4629:
4626:
4624:
4623:
4618:
4604:
4603:
4599:
4598:
4596:
4594:
4593:
4588:
4585:
4583:
4582:
4577:
4567:
4566:
4562:
4561:
4559:
4557:
4556:
4551:
4548:
4546:
4545:
4540:
4530:
4529:
4525:
4523:
4522:
4521:Quadriviridae
4518:
4516:
4515:
4511:
4509:
4508:
4507:Chrysoviridae
4504:
4503:
4501:
4499:
4498:
4497:Ghabrivirales
4493:
4490:
4488:
4487:
4482:
4479:
4477:
4476:
4471:
4468:
4466:
4465:
4464:Orthornavirae
4460:
4457:
4455:
4454:
4449:
4445:
4441:
4440:dsRNA viruses
4435:
4431:
4428:
4426:
4422:
4404:
4403:
4399:
4397:
4396:
4392:
4390:
4389:
4388:Anelloviridae
4384:
4381:
4380:
4378:
4374:
4352:
4351:
4347:
4346:
4344:
4342:
4341:
4340:Haloruvirales
4336:
4333:
4331:
4330:
4325:
4322:
4320:
4319:
4314:
4311:
4309:
4308:
4303:
4285:
4284:
4283:Genomoviridae
4280:
4278:
4277:
4276:Geminiviridae
4273:
4272:
4270:
4268:
4267:
4262:
4259:
4257:
4256:
4251:
4241:
4240:
4236:
4235:
4233:
4231:
4230:
4225:
4219:
4218:
4214:
4212:
4211:
4210:Metaxyviridae
4207:
4206:
4204:
4202:
4201:
4196:
4190:
4189:
4185:
4184:
4182:
4180:
4179:
4174:
4168:
4167:
4163:
4162:
4160:
4158:
4157:
4152:
4146:
4145:
4141:
4140:
4138:
4136:
4135:
4130:
4127:
4125:
4124:
4123:Arfiviricetes
4119:
4116:
4114:
4113:
4108:
4094:
4093:
4089:
4088:
4086:
4084:
4083:
4078:
4075:
4073:
4072:
4067:
4057:
4056:
4052:
4051:
4049:
4047:
4046:
4041:
4038:
4036:
4035:
4030:
4027:
4025:
4024:
4023:Cossaviricota
4019:
4016:
4014:
4013:
4008:
3990:
3989:
3985:
3984:
3982:
3980:
3979:
3974:
3971:
3969:
3968:
3963:
3960:
3958:
3957:
3952:
3949:
3947:
3946:
3941:
3923:
3922:
3918:
3916:
3915:
3911:
3909:
3908:
3904:
3903:
3901:
3899:
3898:
3897:Tubulavirales
3893:
3890:
3888:
3887:
3882:
3879:
3877:
3876:
3871:
3868:
3866:
3865:
3860:
3857:
3855:
3854:
3849:
3845:
3841:
3840:ssDNA viruses
3835:
3831:
3813:
3812:
3811:Rhizidiovirus
3808:
3806:
3805:
3800:
3797:
3795:
3794:
3793:Thaspiviridae
3790:
3788:
3787:
3783:
3781:
3780:
3776:
3774:
3773:
3772:Plasmaviridae
3769:
3767:
3766:
3762:
3760:
3759:
3758:Halspiviridae
3755:
3753:
3752:
3748:
3746:
3745:
3741:
3739:
3738:
3734:
3732:
3731:
3727:
3725:
3724:
3720:
3718:
3717:
3712:
3709:
3708:
3706:
3702:
3692:
3691:
3687:
3686:
3684:
3680:
3674:
3673:
3669:
3667:
3666:
3662:
3660:
3659:
3658:Baculoviridae
3655:
3654:
3652:
3650:
3649:
3644:
3641:
3639:
3638:
3633:
3630:
3626:
3604:
3603:
3599:
3597:
3596:
3595:Simuloviridae
3592:
3590:
3589:
3585:
3584:
3582:
3580:
3579:
3574:
3571:
3569:
3568:
3563:
3560:
3558:
3557:
3552:
3549:
3547:
3546:
3545:Helvetiavirae
3541:
3523:
3522:
3518:
3517:
3515:
3513:
3512:
3507:
3501:
3500:
3496:
3495:
3493:
3491:
3490:
3485:
3479:
3478:
3474:
3473:
3471:
3469:
3468:
3467:Kalamavirales
3463:
3457:
3456:
3452:
3451:
3449:
3447:
3446:
3445:Belfryvirales
3441:
3438:
3436:
3435:
3430:
3420:
3419:
3418:Adintoviridae
3415:
3414:
3412:
3410:
3409:
3404:
3401:
3399:
3398:
3393:
3383:
3382:
3381:Lavidaviridae
3378:
3377:
3375:
3373:
3372:
3367:
3364:
3362:
3361:
3356:
3353:
3351:
3350:
3345:
3331:
3330:
3326:
3324:
3323:
3319:
3317:
3316:
3312:
3311:
3309:
3307:
3306:
3301:
3295:
3294:
3290:
3289:
3287:
3285:
3284:
3283:Imitervirales
3279:
3273:
3272:
3268:
3267:
3265:
3263:
3262:
3257:
3254:
3252:
3251:
3250:Megaviricetes
3246:
3236:
3235:
3231:
3230:
3228:
3226:
3225:
3220:
3214:
3213:
3209:
3208:
3206:
3204:
3203:
3198:
3195:
3193:
3192:
3187:
3184:
3182:
3181:
3176:
3173:
3171:
3170:
3165:
3162:
3160:
3159:
3154:
3132:
3131:
3127:
3126:
3124:
3122:
3121:
3116:
3110:
3109:
3105:
3104:
3102:
3100:
3099:
3098:Sepolyvirales
3094:
3091:
3089:
3088:
3083:
3080:
3078:
3077:
3076:Cossaviricota
3072:
3069:
3067:
3066:
3061:
3058:
3056:
3055:
3050:
3028:
3027:
3026:Zobellviridae
3023:
3021:
3020:
3016:
3014:
3013:
3012:Schitoviridae
3009:
3007:
3006:
3002:
3000:
2999:
2995:
2993:
2992:
2988:
2986:
2985:
2981:
2979:
2978:
2974:
2972:
2971:
2970:Guelinviridae
2967:
2965:
2964:
2960:
2958:
2957:
2953:
2951:
2950:
2946:
2944:
2943:
2939:
2937:
2936:
2932:
2931:
2929:
2927:
2926:
2921:
2918:
2916:
2915:
2910:
2907:
2905:
2904:
2899:
2885:
2884:
2880:
2878:
2877:
2876:Herpesviridae
2873:
2871:
2870:
2866:
2865:
2863:
2861:
2860:
2859:Herpesvirales
2855:
2852:
2850:
2849:
2844:
2841:
2839:
2838:
2837:Peploviricota
2833:
2830:
2828:
2827:
2822:
2819:
2817:
2816:
2815:Duplodnaviria
2811:
2789:
2788:
2784:
2783:
2781:
2779:
2778:
2773:
2767:
2766:
2762:
2760:
2759:
2755:
2754:
2752:
2750:
2749:
2744:
2741:
2739:
2738:
2737:Tokiviricetes
2733:
2730:
2728:
2727:
2726:Taleaviricota
2722:
2719:
2717:
2716:
2711:
2708:
2706:
2705:
2700:
2696:
2692:
2691:dsDNA viruses
2686:
2682:
2679:
2677:
2673:
2668:
2664:
2657:
2652:
2650:
2645:
2643:
2638:
2637:
2634:
2622:
2619:
2617:
2614:
2610:
2607:
2606:
2605:
2602:
2600:
2599:Tandem repeat
2597:
2595:
2592:
2590:
2587:
2583:
2580:
2578:
2575:
2573:
2570:
2568:
2565:
2564:
2562:
2560:
2557:
2554:
2550:
2547:
2546:
2545:
2542:
2540:
2537:
2535:
2532:
2529:
2528:
2527:Nanobacterium
2523:
2521:
2518:
2516:
2513:
2511:
2508:
2506:
2503:
2501:
2498:
2496:
2493:
2489:
2486:
2484:
2481:
2480:
2479:
2476:
2474:
2471:
2470:
2468:
2462:
2452:
2449:
2446:
2443:
2442:
2440:
2436:
2422:
2421:
2420:Rhizidiovirus
2417:
2415:
2414:
2410:
2409:
2407:
2403:
2397:
2396:
2392:
2390:
2389:
2388:Thaspiviridae
2385:
2383:
2382:
2378:
2376:
2375:
2374:Pospiviroidae
2371:
2369:
2368:
2364:
2362:
2361:
2357:
2355:
2354:
2353:Plasmaviridae
2350:
2348:
2347:
2343:
2341:
2340:
2339:Halspiviridae
2336:
2334:
2333:
2329:
2327:
2326:
2322:
2320:
2319:
2315:
2313:
2312:
2308:
2306:
2305:
2301:
2299:
2298:
2294:
2292:
2291:
2290:Avsunviroidae
2287:
2285:
2284:
2283:Anelloviridae
2280:
2278:
2277:
2273:
2271:
2270:
2266:
2265:
2263:
2259:
2255:
2254:
2249:
2245:
2242:
2238:
2232:
2231:
2227:
2225:
2224:
2220:
2218:
2217:
2213:
2211:
2210:
2206:
2204:
2203:
2202:Duplodnaviria
2199:
2197:
2196:
2192:
2191:
2189:
2185:
2182:
2180:
2176:
2172:
2168:
2165:
2161:
2150:
2147:
2145:
2144:
2140:
2139:
2137:
2135:
2134:
2129:
2122:
2118:
2116:
2113:
2111:
2108:
2106:
2103:
2102:
2100:
2098:
2094:
2088:
2085:
2081:
2078:
2076:
2075:Mitochondrion
2073:
2072:
2071:
2068:
2066:
2063:
2062:
2060:
2057:
2052:
2049:
2047:Cellular life
2045:
2040:
2036:
2029:
2024:
2022:
2017:
2015:
2010:
2009:
2006:
1998:
1994:
1989:
1984:
1980:
1976:
1973:(6): 419–53.
1972:
1968:
1964:
1959:
1958:
1954:
1938:
1934:
1928:
1925:
1912:
1908:
1902:
1899:
1886:
1882:
1876:
1873:
1868:
1864:
1860:
1856:
1852:
1850:9780128177228
1846:
1842:
1838:
1834:
1827:
1824:
1811:
1807:
1801:
1799:
1797:
1793:
1788:
1784:
1779:
1774:
1770:
1766:
1762:
1758:
1754:
1750:
1746:
1739:
1736:
1723:
1719:
1713:
1710:
1697:
1693:
1687:
1684:
1679:
1675:
1670:
1665:
1661:
1657:
1653:
1649:
1645:
1641:
1637:
1630:
1628:
1626:
1624:
1620:
1615:
1613:9781444114782
1609:
1605:
1598:
1595:
1582:
1578:
1572:
1570:
1568:
1566:
1562:
1557:
1553:
1548:
1543:
1539:
1535:
1531:
1527:
1523:
1516:
1514:
1512:
1510:
1508:
1506:
1504:
1502:
1500:
1498:
1496:
1494:
1492:
1490:
1486:
1481:
1477:
1472:
1467:
1463:
1459:
1455:
1451:
1447:
1440:
1438:
1436:
1434:
1432:
1428:
1416:
1409:
1402:
1400:
1398:
1396:
1394:
1392:
1390:
1388:
1386:
1384:
1382:
1380:
1378:
1374:
1368:
1360:
1354:
1351:
1344:
1340:
1337:
1336:
1332:
1326:
1321:
1316:
1314:
1312:
1308:
1302:
1300:
1296:
1292:
1291:
1286:
1282:
1278:
1277:
1272:
1268:
1260:
1258:
1255:
1249:
1247:
1243:
1238:
1230:
1228:
1226:
1222:
1218:
1217:fifth disease
1214:
1209:
1207:
1203:
1199:
1195:
1194:
1189:
1188:
1183:
1182:
1181:Geminiviridae
1173:
1168:
1166:
1163:
1159:
1158:Anelloviridae
1154:
1152:
1151:
1146:
1145:
1140:
1139:
1138:Duplodnaviria
1134:
1130:
1126:
1125:
1120:
1116:
1115:
1110:
1109:Anelloviridae
1106:
1101:
1097:
1083:
1082:
1077:
1076:
1075:
1074:
1073:Haloruvirales
1069:
1068:
1067:
1066:
1061:
1060:
1059:
1058:
1053:
1052:
1050:
1046:
1045:
1040:
1030:
1029:
1028:Genomoviridae
1024:
1022:
1021:
1020:Geminiviridae
1016:
1015:
1014:
1013:
1008:
1007:
1006:
1005:
1000:
994:
993:
988:
987:
986:
985:
980:
976:
975:
970:
969:
968:
967:
962:
958:
957:
952:
951:
950:
949:
944:
940:
939:
934:
932:
931:
930:Metaxyviridae
926:
924:
923:
918:
917:
916:
915:
910:
906:
905:
900:
899:
898:
897:
892:
888:
887:
882:
880:
879:
874:
873:
872:
871:
866:
862:
861:
856:
855:
854:
853:
848:
847:
846:
845:
844:Arfiviricetes
840:
839:
838:
837:
832:
824:
823:
818:
817:
816:
815:
810:
809:
808:
807:
802:
796:
795:
790:
789:
788:
787:
782:
778:
777:
772:
771:
770:
769:
768:Sepolyvirales
764:
763:
762:
761:
756:
750:
749:
744:
743:
742:
741:
736:
735:
734:
733:
728:
727:
726:
725:
724:Cossaviricota
720:
719:
717:
716:
711:
710:Cossaviricota
707:
703:
699:
695:
694:
689:
679:
678:
673:
672:
671:
670:
665:
664:
663:
662:
657:
656:
655:
654:
649:
648:
646:
642:
641:cell envelope
638:
637:
632:
622:
621:
616:
614:
613:
608:
606:
605:
600:
599:
598:
597:
596:Tubulavirales
592:
591:
590:
589:
584:
583:
582:
581:
576:
575:
573:
572:
567:
566:
565:
563:
559:
555:
551:
547:
543:
539:
535:
528:
526:
524:
519:
515:
510:
508:
504:
499:
496:
492:
488:
481:Phylogenetics
480:
478:
474:
472:
467:
465:
462:
458:
457:messenger RNA
454:
453:transcription
450:
449:
448:Anelloviridae
443:
441:
436:
432:
424:
422:
420:
416:
412:
411:Cossaviricota
408:
404:
399:
396:
395:hairpin loops
392:
388:
384:
383:
382:Cossaviricota
378:
377:
372:
371:
366:
358:
356:
353:
349:
344:
342:
337:
335:
330:
325:
320:
318:
314:
310:
306:
302:
298:
294:
293:Endonucleases
290:
282:
277:
275:
273:
269:
265:
261:
257:
253:
249:
245:
241:
237:
233:
226:
224:
222:
219:. Members of
218:
214:
210:
204:
202:
198:
194:
190:
186:
183:
179:
175:
171:
167:
163:
159:
158:
153:
152:
147:
146:
141:
140:
135:
131:
130:replication.
128:
124:
120:
116:
112:
108:
104:
103:
94:
93:
88:
83:
80:
79:
75:
72:
69:
68:
65:
62:
59:
58:
53:
48:
44:
40:
36:
32:
27:
24:
20:
6543:Virus realms
6538:Monodnaviria
6501:Monodnaviria
6471:Monodnaviria
6470:
6415:
6407:Ortervirales
6405:
6393:
6383:
6372:
6361:
6352:Pararnavirae
6350:
6339:
6287:Retroviridae
6285:
6278:
6271:
6264:
6256:Ortervirales
6254:
6243:
6232:
6223:Pararnavirae
6221:
6210:
6143:
6133:
6122:
6108:Xinmoviridae
6106:
6099:
6092:
6085:
6078:
6073:Nyamiviridae
6071:
6064:
6059:Lispiviridae
6057:
6050:
6045:Bornaviridae
6043:
6036:
6026:
6014:
6009:Myriaviridae
6007:
6000:
5993:
5988:Aliusviridae
5986:
5976:
5965:
5949:
5939:
5928:
5912:
5905:
5895:
5884:
5868:
5863:Tospoviridae
5861:
5854:
5847:
5840:
5835:Nairoviridae
5833:
5826:
5819:
5814:Hantaviridae
5812:
5805:
5800:Arenaviridae
5798:
5793:Cruliviridae
5791:
5783:Bunyavirales
5781:
5770:
5754:
5744:
5733:
5722:
5711:
5700:
5654:
5647:
5643:
5619:Astroviridae
5617:
5607:
5595:
5585:
5574:
5558:
5553:Barnaviridae
5551:
5544:
5534:
5522:
5515:
5508:
5501:
5494:
5487:
5482:Marnaviridae
5480:
5473:
5463:
5451:
5444:
5439:Olifoviridae
5437:
5430:
5423:
5416:
5409:
5402:
5395:
5388:
5381:
5374:
5367:
5360:
5350:
5339:
5330:Pisuviricota
5328:
5308:
5300:Ourlivirales
5298:
5289:Miaviricetes
5287:
5271:
5261:
5250:
5236:Narnaviridae
5234:
5224:
5213:
5197:
5192:Blumeviridae
5190:
5182:Timlovirales
5180:
5168:
5163:Fiersviridae
5161:
5154:
5147:
5139:Norzivirales
5137:
5126:
5115:
5095:
5090:Luteoviridae
5088:
5081:
5071:
5060:
5044:
5037:
5027:
5016:
5002:Flaviviridae
5000:
4990:
4979:
4963:
4956:
4949:
4942:
4935:
4925:
4915:Virgaviridae
4913:
4906:
4899:
4892:
4885:
4878:
4873:Bromoviridae
4871:
4861:
4849:
4842:
4835:
4828:
4818:
4807:
4796:
4785:
4774:
4728:
4724:
4717:
4712:Birnaviridae
4710:
4706:
4680:
4673:
4666:
4659:
4652:
4644:Durnavirales
4642:
4631:
4622:Pisuviricota
4620:
4602:Cystoviridae
4600:
4592:Mindivirales
4590:
4579:
4563:
4553:
4542:
4526:
4519:
4512:
4505:
4495:
4484:
4473:
4462:
4451:
4402:Spiraviridae
4400:
4393:
4386:
4382:
4348:
4338:
4327:
4318:Saleviricota
4316:
4305:
4281:
4274:
4264:
4253:
4237:
4229:Recrevirales
4227:
4215:
4208:
4200:Mulpavirales
4198:
4188:Smacoviridae
4186:
4178:Cremevirales
4176:
4166:Circoviridae
4164:
4156:Cirlivirales
4154:
4142:
4134:Baphyvirales
4132:
4121:
4110:
4092:Parvoviridae
4090:
4082:Piccovirales
4080:
4069:
4055:Bidnaviridae
4053:
4043:
4034:Mouviricetes
4032:
4021:
4012:Shotokuvirae
4010:
3988:Microviridae
3986:
3978:Petitvirales
3976:
3965:
3956:Phixviricota
3954:
3943:
3919:
3912:
3905:
3895:
3884:
3873:
3862:
3853:Monodnaviria
3852:
3851:
3809:
3804:Dinodnavirus
3802:
3798:
3791:
3784:
3777:
3770:
3765:Ovaliviridae
3763:
3756:
3751:Guttaviridae
3749:
3742:
3735:
3730:Clavaviridae
3728:
3721:
3714:
3710:
3688:
3670:
3663:
3656:
3646:
3635:
3600:
3593:
3586:
3576:
3565:
3554:
3543:
3519:
3509:
3499:Adenoviridae
3497:
3487:
3477:Tectiviridae
3475:
3465:
3455:Turriviridae
3453:
3443:
3432:
3416:
3406:
3395:
3379:
3369:
3358:
3347:
3327:
3322:Iridoviridae
3320:
3313:
3303:
3291:
3281:
3269:
3259:
3248:
3232:
3224:Chitovirales
3222:
3212:Asfarviridae
3210:
3200:
3189:
3178:
3169:Bamfordvirae
3167:
3158:Varidnaviria
3156:
3128:
3118:
3106:
3096:
3085:
3074:
3065:Shotokuvirae
3063:
3054:Monodnaviria
3053:
3052:
3024:
3019:Siphoviridae
3017:
3010:
3003:
2996:
2989:
2982:
2975:
2968:
2961:
2954:
2949:Chaseviridae
2947:
2940:
2933:
2925:Caudovirales
2923:
2912:
2901:
2881:
2874:
2867:
2857:
2846:
2835:
2824:
2813:
2785:
2777:Primavirales
2775:
2763:
2756:
2746:
2735:
2724:
2713:
2702:
2616:Transpoviron
2549:Fungal prion
2525:
2418:
2413:Dinodnavirus
2411:
2393:
2386:
2381:Spiraviridae
2379:
2372:
2365:
2358:
2351:
2346:Ovaliviridae
2344:
2337:
2332:Guttaviridae
2330:
2323:
2316:
2309:
2304:Clavaviridae
2302:
2295:
2288:
2281:
2274:
2267:
2251:
2230:Varidnaviria
2228:
2221:
2214:
2209:Monodnaviria
2208:
2207:
2200:
2193:
2141:
2131:
1970:
1966:
1941:. Retrieved
1936:
1927:
1915:. Retrieved
1910:
1901:
1889:. Retrieved
1884:
1875:
1832:
1826:
1814:. Retrieved
1809:
1752:
1748:
1738:
1726:. Retrieved
1721:
1712:
1700:. Retrieved
1695:
1686:
1643:
1639:
1604:Parvoviruses
1603:
1597:
1585:. Retrieved
1580:
1529:
1526:Virusdisease
1525:
1453:
1449:
1418:. Retrieved
1414:
1353:
1311:polyphyletic
1307:Monodnaviria
1306:
1303:
1299:Parvoviridae
1298:
1295:Monodnaviria
1294:
1288:
1274:
1267:Monodnaviria
1266:
1264:
1250:
1234:
1210:
1206:algal blooms
1193:Circoviridae
1191:
1185:
1179:
1177:
1162:Monodnaviria
1161:
1157:
1155:
1150:Varidnaviria
1148:
1142:
1136:
1133:Monodnaviria
1132:
1129:Monodnaviria
1128:
1124:Spiraviridae
1122:
1119:Varidnaviria
1118:
1112:
1108:
1105:Monodnaviria
1104:
1096:Monodnaviria
1095:
1094:
1079:
1071:
1063:
1057:Saleviricota
1055:
1042:
1026:
1018:
1010:
1002:
992:Nenyaviridae
990:
984:Rohanvirales
982:
974:Naryaviridae
972:
964:
954:
948:Recrevirales
946:
936:
928:
922:Amesuviridae
920:
914:Mulpavirales
912:
904:Smacoviridae
902:
896:Cremevirales
894:
886:Vilyaviridae
884:
878:Circoviridae
876:
870:Cirlivirales
868:
858:
852:Baphyvirales
850:
842:
834:
822:Parvoviridae
820:
814:Piccovirales
812:
804:
792:
784:
774:
766:
758:
748:Bidnaviridae
746:
738:
732:Mouviricetes
730:
722:
713:
709:
706:Shotokuvirae
705:
693:Shotokuvirae
691:
677:Microviridae
675:
669:Petitvirales
667:
659:
653:Phixviricota
651:
644:
634:
618:
610:
602:
594:
586:
578:
569:
561:
557:
553:
549:
546:Shotokuvirae
545:
541:
537:
534:Monodnaviria
533:
532:
518:Monodnaviria
517:
514:Monodnaviria
513:
511:
502:
500:
491:Monodnaviria
490:
484:
475:
468:
446:
444:
431:Monodnaviria
430:
428:
410:
406:
402:
400:
387:Shotokuvirae
386:
380:
376:Bidnaviridae
374:
370:Parvoviridae
368:
365:Monodnaviria
364:
362:
345:
338:
321:
311:made of two
289:Monodnaviria
288:
286:
271:
267:
263:
259:
256:Monodnaviria
255:
251:
247:
239:
232:Monodnaviria
231:
230:
221:Monodnaviria
220:
205:
201:Monodnaviria
200:
174:Monodnaviria
173:
166:Shotokuvirae
165:
157:Shotokuvirae
155:
149:
143:
137:
134:Monodnaviria
133:
132:
102:Monodnaviria
101:
100:
99:
90:
78:Monodnaviria
77:
76:
70:
60:(unranked):
39:Parvoviruses
23:Monodnaviria
22:
6495:Wikispecies
6273:Metaviridae
6052:Filoviridae
6038:Artoviridae
5951:Aspiviridae
5828:Mypoviridae
5807:Fimoviridae
5597:Potyviridae
5510:Secoviridae
5503:Iflaviridae
5446:Roniviridae
5352:Nidovirales
5273:Mitoviridae
5156:Duinviridae
5073:Tolivirales
5039:Nodaviridae
4965:Tymoviridae
4927:Tymovirales
4908:Togaviridae
4901:Mayoviridae
4894:Kitaviridae
4844:Hepeviridae
4837:Benyviridae
4668:Hypoviridae
4528:Totiviridae
4217:Nanoviridae
4045:Polivirales
3945:Sangervirae
3690:Nimaviridae
3672:Nudiviridae
3648:Lefavirales
3511:Vinavirales
3489:Rowavirales
3315:Ascoviridae
3293:Mimiviridae
3261:Algavirales
3202:Asfuvirales
2991:Podoviridae
2903:Uroviricota
2765:Rudiviridae
2715:Zilligvirae
2559:microsphere
2478:Cancer cell
2223:Ribozyviria
1646:(1): 3425.
1532:(1): 3–12.
1187:Nanoviridae
938:Nanoviridae
740:Polivirales
645:Sangervirae
636:Sangervirae
558:Sangervirae
542:Sangervirae
464:translation
435:icosahedral
274:" viruses.
236:portmanteau
197:RNA viruses
162:prokaryotes
145:Sangervirae
6532:Categories
6145:Yueviridae
6101:Sunviridae
5995:Chuviridae
5756:Qinviridae
5637:Unassigned
4700:Unassigned
4565:Reoviridae
4555:Reovirales
4376:Unassigned
4307:Trapavirae
3907:Inoviridae
3704:Unassigned
3682:Unassigned
3628:Unassigned
3234:Poxviridae
2984:Myoviridae
2609:Retroposon
2556:Proteinoid
2466:structures
2464:Comparable
2240:Unassigned
2143:Parakaryon
2056:Prokaryota
1640:Nat Commun
1369:References
1359:inoviruses
1281:circovirus
1276:Eupatorium
1237:homologues
1044:Trapavirae
604:Inoviridae
562:Trapavirae
550:Trapavirae
170:eukaryotes
151:Trapavirae
6486:Q91894429
6341:Riboviria
6212:Riboviria
5746:Muvirales
5702:Riboviria
4776:Riboviria
4453:Riboviria
3864:Loebvirae
2704:Adnaviria
2663:Baltimore
2216:Riboviria
2195:Adnaviria
2179:Satellite
2097:Eukaryota
1937:ViralZone
1911:ViralZone
1885:ViralZone
1722:ViralZone
1696:ViralZone
1581:ViralZone
1246:transpose
1242:integrase
1213:in canids
1156:Although
1144:Riboviria
1041:Kingdom:
690:Kingdom:
633:Kingdom:
571:Loebvirae
568:Kingdom:
554:Loebvirae
538:Loebvirae
503:Riboviria
487:helicases
461:ribosomal
313:histidine
303:within a
227:Etymology
178:bacterial
139:Loebvirae
41:in blood
6480:Wikidata
5644:Families
4707:Families
4383:Families
3711:Families
2589:Ribozyme
2534:Phagemid
2261:Families
2121:Protista
2105:Animalia
2070:Bacteria
1867:58636379
1859:30635078
1816:25 April
1787:24939392
1755:: 5347.
1678:31366885
1556:31143827
1480:23832240
1317:See also
1078:Family:
1054:Phylum:
1025:Family:
1017:Family:
989:Family:
971:Family:
953:Family:
935:Family:
927:Family:
919:Family:
901:Family:
883:Family:
875:Family:
857:Family:
833:Phylum:
819:Family:
791:Family:
773:Family:
745:Family:
721:Phylum:
674:Family:
650:Phylum:
617:Family:
609:Family:
601:Family:
577:Phylum:
523:polinton
495:chimeric
341:hydroxyl
317:tyrosine
270:ncoding
262:ircular
185:plasmids
182:archaeal
92:See text
85:Subtaxa
6515:2731342
2621:Xenobot
2539:Plasmid
2520:Jeewanu
2451:Obelisk
2247:Classes
2115:Plantae
2080:Plastid
2065:Archaea
1997:8140287
1988:7135741
1778:4061559
1757:Bibcode
1749:Sci Rep
1728:15 June
1669:6668415
1648:Bibcode
1547:6517461
1471:6493337
1261:History
1202:diatoms
1174:Disease
1070:Order:
1062:Class:
1009:Order:
1001:Class:
981:Order:
963:Order:
945:Order:
911:Order:
893:Order:
867:Order:
849:Order:
841:Class:
811:Order:
803:Class:
783:Order:
765:Order:
757:Class:
737:Order:
729:Class:
666:Order:
658:Class:
593:Order:
585:Class:
297:enzymes
242:, from
217:cancers
168:infect
111:viruses
4725:Genera
3799:Genera
2567:Retron
2510:Fosmid
2495:Cosmid
2445:Nanobe
2405:Genera
2187:Realms
2175:Viroid
1995:
1985:
1943:27 May
1917:27 May
1891:27 May
1865:
1857:
1847:
1785:
1775:
1702:27 May
1676:
1666:
1610:
1587:27 May
1554:
1544:
1478:
1468:
1420:27 May
1411:(docx)
1147:, and
1121:, and
548:, and
154:, and
119:encode
6326:VII:
4438:III:
2544:Prion
2438:Other
2171:Virus
2110:Fungi
1863:S2CID
1345:Notes
1225:warts
415:theta
309:motif
272:ssDNA
252:viria
244:Greek
234:is a
117:that
107:realm
105:is a
71:Realm
64:Virus
6510:NCBI
6197:VI:
4761:IV:
3838:II:
2483:HeLa
2087:LUCA
2035:Life
1993:PMID
1945:2020
1919:2020
1893:2020
1855:PMID
1845:ISBN
1818:2020
1783:PMID
1730:2020
1704:2020
1674:PMID
1608:ISBN
1589:2020
1552:PMID
1476:PMID
1422:2020
1184:and
560:and
405:and
373:and
295:are
240:mono
211:and
180:and
5687:V:
4425:RNA
2689:I:
2676:DNA
2447:(?)
2151:(?)
1983:PMC
1975:doi
1971:144
1837:doi
1773:PMC
1765:doi
1664:PMC
1656:doi
1542:PMC
1534:doi
1466:PMC
1458:doi
1244:or
266:ep-
248:DNA
238:of
121:an
109:of
6534::
6512::
6497::
6482::
6184:RT
5646::
4727::
4709::
4385::
3801::
3713::
2037:,
1991:.
1981:.
1969:.
1965:.
1935:.
1909:.
1883:.
1861:.
1853:.
1843:.
1808:.
1795:^
1781:.
1771:.
1763:.
1751:.
1747:.
1720:.
1694:.
1672:.
1662:.
1654:.
1644:10
1642:.
1638:.
1622:^
1579:.
1564:^
1550:.
1540:.
1530:30
1528:.
1524:.
1488:^
1474:.
1464:.
1454:11
1452:.
1448:.
1430:^
1413:.
1376:^
1227:.
1208:.
1153:.
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1111:,
718:.
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2027:e
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2013:v
1999:.
1977::
1947:.
1921:.
1895:.
1869:.
1839::
1820:.
1789:.
1767::
1759::
1753:4
1732:.
1706:.
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1658::
1650::
1616:.
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1558:.
1536::
1482:.
1460::
1424:.
268:e
264:R
260:c
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