Knowledge (XXG)

NFKBIZ

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has been implicated as an oncogene in diffuse large B-cell lymphoma (DLBCL). Specifically, genomic locus containing this gene is recurrently amplified in copy number in the activated B-cell (ABC) subgroup of DLBCL. More recently, a recurrence of somatic mutations affecting the 3-prime untranslated
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Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, Saitoh T, Yamaoka S, Yamamoto N, Yamamoto S, Muta T, Takeda K, Akira S (July 2004). "Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta".
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Shiina T, Morimatsu M, Kitamura H, Ito T, Kidou S, Matsubara K, Matsuda Y, Saito M, Syuto B (October 2001). "Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene".
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Yamaji D, Kitamura H, Kimura K, Matsushita Y, Okada H, Shiina T, Morimatsu M, Saito M (April 2004). "Cloning of bovine MAIL and its mRNA expression in white blood cells of Holstein cows".
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Eto A, Muta T, Yamazaki S, Takeshige K (February 2003). "Essential roles for NF-kappa B and a Toll/IL-1 receptor domain-specific signal(s) in the induction of I kappa B-zeta".
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Ito T, Morimatsu M, Oonuma T, Shiina T, Kitamura H, Syuto B (November 2004). "Transcriptional regulation of the MAIL gene in LPS-stimulated RAW264 mouse macrophages".
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Kitamura H, Kanehira K, Okita K, Morimatsu M, Saito M (November 2000). "MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production".
1813:"Stimulus-specific induction of a novel nuclear factor-kappaB regulator, IkappaB-zeta, via Toll/Interleukin-1 receptor is mediated by mRNA stabilization" 689: 670: 79: 1042: 2070: 2046: 1143: 1125: 2065: 243: 913: 1569:"A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei" 920: 220: 1283: 1848:"Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein" 1112: 1091: 1108: 142: 117: 1087: 59: 1002:
repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in
256: 155: 1242:"IκBζ is a regulator of the senescence-associated secretory phenotype in DNA damage- and oncogene-induced senescence" 249: 148: 2039: 1014:. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of 1198:"A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding" 734: 67: 1639:"Bacterial lipopolysaccharide-induced expression of the IkappaB protein MAIL in B-lymphocytes and macrophages" 1953:"Crucial roles of binding sites for NF-kappaB and C/EBPs in IkappaB-zeta-mediated transcriptional activation" 1883:"IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta" 1246: 715: 1674:"Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease" 1637:
Kitamura H, Matsushita Y, Iwanaga T, Mori K, Kanehira K, Fujikura D, Morimatsu M, Saito M (March 2003).
1284:"Entrez Gene: NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta" 1672:
Shiina T, Konno A, Oonuma T, Kitamura H, Imaoka K, Takeda N, Todokoro K, Morimatsu M (December 2004).
1604:"Bacterial lipopolysaccharide induces mRNA expression of an IkappaB MAIL through toll-like receptor 4" 2032: 1746: 1359: 131: 46: 892: 888: 863: 833: 829: 808: 1770: 1520: 1482: 1328: 991: 91: 896: 867: 837: 804: 1982: 1939: 1904: 1869: 1834: 1799: 1762: 1724: 1695: 1660: 1625: 1590: 1555: 1512: 1474: 1434: 1385: 1346:
Arthur SE, Jiang A, Grande BM, Alcaide M, Cojocaru R, Rushton CK, et al. (October 2018).
1320: 1265: 1219: 1178: 39: 2016: 1972: 1964: 1929: 1894: 1859: 1824: 1791: 1754: 1716: 1685: 1650: 1615: 1580: 1545: 1534:"Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs" 1504: 1466: 1424: 1416: 1375: 1367: 1310: 1297:
Nogai H, Wenzel SS, Hailfinger S, Grau M, Kaergel E, Seitz V, et al. (September 2013).
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Totzke G, Essmann F, Pohlmann S, Lindenblatt C, Jänicke RU, Schulze-Osthoff K (May 2006).
1063: 311: 1750: 1363: 1977: 1952: 1429: 1380: 1348:"Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma" 1347: 1011: 1602:
Kitamura H, Kanehira K, Shiina T, Morimatsu M, Jung BD, Akashi S, Saito M (May 2002).
1470: 1404: 1241: 1174: 604: 599: 594: 589: 584: 579: 574: 558: 553: 548: 532: 527: 2059: 1299:"IκB-ζ controls the constitutive NF-κB target gene network and survival of ABC DLBCL" 1015: 514: 1524: 1486: 1332: 71: 2012: 1774: 1003: 329: 108: 1918:"Role of NF-kappaB in constitutive expression of MAIL in epidermal keratinocytes" 1795: 1315: 1298: 95: 1899: 1882: 1420: 1148:
National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
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Motoyama M, Yamazaki S, Eto-Kimura A, Takeshige K, Muta T (March 2005).
1758: 1620: 1603: 990:. This gene is a member of the ankyrin-repeat family and is induced by 1968: 1655: 1638: 1260: 999: 980: 746: 701: 1916:
Oonuma T, Morimatsu M, Ochiai K, Iwanaga T, Hashizume K (March 2007).
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Alexander E, Hildebrand DG, Schulze-Osthoff K, Essmann F (2013).
619: 615: 2008: 1045: 987: 63: 1405:"Flavonoids: Broad Spectrum Agents on Chronic Inflammation" 1811:
Yamazaki S, Muta T, Matsuo S, Takeshige K (January 2005).
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Matsuo S, Yamazaki S, Takeshige K, Muta T (August 2007).
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production. Two transcript variants encoding different
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positive regulation of T-helper 17 cell differentiation
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were found to promote NFKBIZ expression in ABC DLBCL.
1052:, which recruits macrophages to remove cancer cells. 484: 1163:
Biochemical and Biophysical Research Communications
881: 856: 822: 797: 1104: 1102: 1100: 1083: 1081: 1079: 998:portion of the encoded product which contains the 266: 165: 575:regulation of transcription by RNA polymerase II 16:Protein-coding gene in the species Homo sapiens 1235: 1233: 1109:GRCm38: Ensembl release 89: ENSMUSG00000035356 2040: 1881:Cowland JB, Muta T, Borregaard N (May 2006). 1567:Yamazaki S, Muta T, Takeshige K (July 2001). 8: 605:positive regulation of inflammatory response 1532:Haruta H, Kato A, Todokoro K (April 2001). 1088:GRCh38: Ensembl release 89: ENSG00000144802 1006:responses to LPS by their interaction with 2047: 2033: 630: 585:regulation of transcription, DNA-templated 510: 307: 206: 103: 1976: 1933: 1922:The Journal of Veterinary Medical Science 1898: 1863: 1828: 1784:Veterinary Immunology and Immunopathology 1689: 1654: 1619: 1608:The Journal of Veterinary Medical Science 1584: 1549: 1428: 1379: 1314: 1259: 1213: 1041:IκBζ is required for expression of the 1075: 50:, IKBZ, INAP, MAIL, NFKB inhibitor zeta 20: 559:cytoplasmic ribonucleoprotein granule 271: 232: 227: 170: 129: 124: 7: 1997: 1995: 1852:The Journal of Biological Chemistry 1817:The Journal of Biological Chemistry 1678:The Journal of Biological Chemistry 1573:The Journal of Biological Chemistry 1538:The Journal of Biological Chemistry 1202:The Journal of Biological Chemistry 2019:. You can help Knowledge (XXG) by 1643:Archives of Histology and Cytology 878: 853: 819: 794: 770: 751: 725: 706: 680: 661: 533:transcription coregulator activity 489: 407: 345: 324: 14: 983:that in humans is encoded by the 595:T cell receptor signaling pathway 1999: 255: 248: 242: 219: 154: 147: 141: 116: 1409:Biomolecules & Therapeutics 1022:have been found for this gene. 1403:Lim H, Heo MY, Kim HP (2019). 473:More reference expression data 1: 2071:Human chromosome 3 gene stubs 1471:10.1016/S0014-5793(00)02185-2 1175:10.1016/S0006-291X(02)03082-6 240: 139: 1796:10.1016/j.vetimm.2003.12.004 1316:10.1182/blood-2013-06-508028 590:transcription, DNA-templated 2066:Genes on human chromosome 3 1900:10.4049/jimmunol.176.9.5559 1421:10.4062/biomolther.2019.034 2087: 1994: 1721:10.1016/j.gene.2004.07.032 1372:10.1038/s41467-018-06354-3 361:pancreatic epithelial cell 1509:10.1007/s00251-001-0376-x 1144:"Mouse PubMed Reference:" 1126:"Human PubMed Reference:" 1062:has been shown to reduce 973:NF-kappa-B inhibitor zeta 959: 954: 950: 943: 927: 914:Chr 3: 101.83 – 101.86 Mb 908: 885: 860: 849: 826: 801: 790: 777: 773: 758: 754: 745: 732: 728: 713: 709: 700: 687: 683: 668: 664: 655: 640: 633: 629: 613: 513: 509: 497: 492: 483: 470: 419: 410: 357: 348: 318: 310: 306: 289: 276: 239: 218: 209: 205: 188: 175: 138: 115: 106: 102: 57: 54: 44: 37: 32: 28: 23: 921:Chr 16: 55.63 – 55.66 Mb 1957:The Biochemical Journal 1247:Journal of Cell Science 1865:10.1074/jbc.M412738200 1830:10.1074/jbc.M409983200 1691:10.1074/jbc.M409770200 1586:10.1074/jbc.M103426200 1551:10.1074/jbc.C100075200 1215:10.1074/jbc.M511956200 1012:ankyrin-repeat domains 439:mucous cell of stomach 365:pancreatic ductal cell 1887:Journal of Immunology 1352:Nature Communications 580:inflammatory response 443:stroma of bone marrow 369:palpebral conjunctiva 234:Chromosome 16 (mouse) 1254:(Pt 16): 3738–3745. 132:Chromosome 3 (human) 1935:10.1292/jvms.69.279 1759:10.1038/nature02738 1751:2004Natur.430..218Y 1621:10.1292/jvms.64.419 1364:2018NatCo...9.4001A 435:conjunctival fornix 431:islet of Langerhans 2007:This article on a 1969:10.1042/BJ20061797 1656:10.1679/aohc.66.53 1261:10.1242/jcs.128835 1026:Clinical relevance 992:lipopolysaccharide 735:ENSMUSG00000035356 568:Biological process 542:Cellular component 521:Molecular function 96:NFKBIZ - orthologs 2028: 2027: 1010:proteins through 970: 969: 966: 965: 939: 938: 904: 903: 875: 874: 845: 844: 816: 815: 786: 785: 767: 766: 741: 740: 722: 721: 696: 695: 677: 676: 625: 624: 505: 504: 501: 500: 479: 478: 466: 465: 404: 403: 389:bone marrow cells 302: 301: 201: 200: 2078: 2049: 2042: 2035: 2003: 1996: 1990: 1980: 1947: 1937: 1912: 1902: 1877: 1867: 1842: 1832: 1807: 1778: 1745:(6996): 218–22. 1732: 1703: 1693: 1668: 1658: 1633: 1623: 1598: 1588: 1579:(29): 27657–62. 1563: 1553: 1528: 1490: 1443: 1442: 1432: 1400: 1394: 1393: 1383: 1343: 1337: 1336: 1318: 1294: 1288: 1287: 1280: 1274: 1273: 1263: 1237: 1228: 1227: 1217: 1208:(18): 12645–54. 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887: 866: 862: 836: 832: 828: 807: 803: 716:ENSG00000144802 609: 563: 537: 528:protein binding 471: 462: 457: 453: 449: 445: 441: 437: 433: 429: 425: 411: 400: 395: 391: 387: 385:visceral pleura 383: 379: 377:parietal pleura 375: 371: 367: 363: 349: 293: 280: 273:16|16 C1.1 272: 262: 261: 260: 253: 233: 210:Gene location ( 192: 179: 171: 161: 160: 159: 152: 130: 107:Gene location ( 58: 45: 38: 17: 12: 11: 5: 2084: 2082: 2074: 2073: 2068: 2058: 2057: 2052: 2051: 2044: 2037: 2029: 2026: 2025: 2004: 1992: 1991: 1948: 1913: 1893:(9): 5559–66. 1878: 1858:(9): 7444–51. 1843: 1823:(2): 1678–87. 1808: 1779: 1733: 1704: 1669: 1634: 1599: 1564: 1529: 1497:Immunogenetics 1491: 1453: 1451: 1448: 1445: 1444: 1415:(3): 241–253. 1395: 1338: 1289: 1275: 1229: 1188: 1169:(2): 495–501. 1153: 1135: 1117: 1096: 1074: 1073: 1071: 1068: 1027: 1024: 968: 967: 964: 963: 958: 948: 947: 941: 940: 937: 936: 934: 932: 925: 924: 917: 910: 906: 905: 902: 901: 883: 882: 876: 873: 872: 858: 857: 851: 847: 846: 843: 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750: 748: 744: 737: 736: 731: 727: 724: 718: 717: 712: 708: 705: 703: 699: 692: 691: 686: 682: 679: 673: 672: 667: 663: 660: 658: 654: 651: 648: 646: 643: 639: 636: 632: 628: 621: 617: 612: 606: 603: 601: 598: 596: 593: 591: 588: 586: 583: 581: 578: 576: 573: 572: 570: 567: 566: 560: 557: 555: 554:nuclear speck 552: 550: 547: 546: 544: 541: 540: 534: 531: 529: 526: 525: 523: 520: 519: 516: 515:Gene ontology 512: 508: 496: 491: 488: 486: 482: 474: 469: 458: 454: 450: 446: 442: 438: 434: 430: 426: 422: 421: 418: 414: 409: 406: 396: 392: 388: 384: 380: 376: 373:skin of thigh 372: 368: 364: 360: 359: 356: 352: 347: 344: 343: 340: 338: 334: 332: 331: 327: 326: 323: 321: 317: 313: 309: 305: 297: 292: 288: 284: 279: 269: 265: 258: 251: 245: 238: 230: 226: 222: 217: 213: 208: 204: 196: 191: 187: 183: 178: 168: 164: 157: 150: 144: 137: 133: 127: 123: 119: 114: 110: 105: 101: 97: 93: 89: 85: 81: 77: 73: 69: 65: 61: 53: 48: 41: 36: 31: 27: 22: 19: 2021:expanding it 2013:chromosome 3 2006: 1960: 1956: 1925: 1921: 1890: 1886: 1855: 1851: 1820: 1816: 1787: 1783: 1742: 1738: 1712: 1708: 1681: 1677: 1649:(1): 53–62. 1646: 1642: 1611: 1607: 1576: 1572: 1541: 1537: 1500: 1496: 1462: 1459:FEBS Letters 1458: 1412: 1408: 1398: 1355: 1351: 1341: 1306: 1302: 1292: 1278: 1251: 1245: 1205: 1201: 1191: 1166: 1162: 1156: 1147: 1138: 1129: 1120: 1054: 1040: 1035: 1030: 1029: 1004:inflammatory 984: 976: 972: 971: 893:NP_001152867 889:NP_001152866 886: 864:NP_001005474 861: 834:NM_001159395 830:NM_001159394 827: 809:NM_001005474 802: 778: 759: 733: 714: 688: 669: 649: 644: 335: 328: 193:101,861,022 180:101,827,991 55:External IDs 18: 1465:(1): 53–6. 1358:(1): 4001. 994:(LPS). The 427:Paneth cell 423:granulocyte 294:55,659,262 281:55,631,738 33:Identifiers 2060:Categories 1115:, May 2017 1094:, May 2017 1070:References 1034:region of 996:C-terminal 339:(ortholog) 76:HomoloGene 2011:on human 1066:of IκBζ. 1057:flavonoid 897:NP_085115 868:NP_113607 838:NM_030612 805:NM_031419 635:Orthologs 84:GeneCards 1987:17447895 1944:17409644 1909:16622025 1874:15618216 1839:15522867 1804:15010226 1767:15241416 1729:15527973 1700:15491998 1665:12703554 1630:12069074 1595:11356851 1560:11278262 1525:12387932 1517:11797098 1487:85416608 1479:11086164 1439:31006180 1390:30275490 1333:18427175 1325:23869088 1270:23781024 1224:16513645 1183:12565889 1111:– 1090:– 1060:apigenin 1050:cytokine 1020:isoforms 945:Wikidata 614:Sources: 455:duodenum 1978:2267307 1775:4384768 1747:Bibcode 1430:6513185 1381:6167379 1360:Bibcode 1113:Ensembl 1092:Ensembl 1048:(MCP1) 1000:ankyrin 981:protein 979:) is a 747:UniProt 702:Ensembl 641:Species 620:QuickGO 549:nucleus 451:jejunum 381:trachea 314:pattern 72:1931595 40:Aliases 1985:  1975:  1942:  1907:  1872:  1837:  1802:  1773:  1765:  1739:Nature 1727:  1698:  1663:  1628:  1593:  1558:  1523:  1515:  1485:  1477:  1437:  1427:  1388:  1378:  1331:  1323:  1268:  1222:  1181:  1036:NFKBIZ 1031:NFKBIZ 985:NFKBIZ 931:search 929:PubMed 780:Q9EST8 761:Q9BYH8 657:Entrez 485:BioGPS 172:3q12.3 88:NFKBIZ 64:608004 47:NFKBIZ 24:NFKBIZ 2015:is a 1771:S2CID 1521:S2CID 1483:S2CID 1329:S2CID 1303:Blood 1008:NF-κB 690:80859 671:64332 650:Mouse 645:Human 616:Amigo 337:Mouse 330:Human 277:Start 212:Mouse 176:Start 109:Human 80:12734 2017:stub 2009:gene 1983:PMID 1940:PMID 1905:PMID 1870:PMID 1835:PMID 1800:PMID 1763:PMID 1725:PMID 1709:Gene 1696:PMID 1661:PMID 1626:PMID 1591:PMID 1556:PMID 1513:PMID 1475:PMID 1435:PMID 1386:PMID 1321:PMID 1266:PMID 1220:PMID 1179:PMID 1055:The 1046:CCL2 1043:SASP 1016:IL-6 988:gene 977:IκBζ 320:Bgee 268:Band 229:Chr. 167:Band 126:Chr. 60:OMIM 1973:PMC 1965:doi 1961:405 1930:doi 1895:doi 1891:176 1860:doi 1856:280 1825:doi 1821:280 1792:doi 1755:doi 1743:430 1717:doi 1713:342 1686:doi 1682:279 1651:doi 1616:doi 1581:doi 1577:276 1546:doi 1542:276 1505:doi 1467:doi 1463:485 1425:PMC 1417:doi 1376:PMC 1368:doi 1311:doi 1307:122 1256:doi 1252:126 1210:doi 1206:281 1171:doi 1167:301 493:n/a 290:End 189:End 92:OMA 68:MGI 2062:: 1981:. 1971:. 1959:. 1955:. 1938:. 1926:69 1924:. 1920:. 1903:. 1889:. 1885:. 1868:. 1854:. 1850:. 1833:. 1819:. 1815:. 1798:. 1788:98 1786:. 1769:. 1761:. 1753:. 1741:. 1723:. 1711:. 1694:. 1680:. 1676:. 1659:. 1647:66 1645:. 1641:. 1624:. 1612:64 1610:. 1606:. 1589:. 1575:. 1571:. 1554:. 1540:. 1536:. 1519:. 1511:. 1501:53 1499:. 1481:. 1473:. 1461:. 1433:. 1423:. 1413:27 1411:. 1407:. 1384:. 1374:. 1366:. 1354:. 1350:. 1327:. 1319:. 1305:. 1301:. 1264:. 1250:. 1244:. 1232:^ 1218:. 1204:. 1200:. 1177:. 1165:. 1146:. 1128:. 1099:^ 1078:^ 618:/ 296:bp 283:bp 195:bp 182:bp 90:; 86:: 82:; 78:: 74:; 70:: 66:; 62:: 2048:e 2041:t 2034:v 2023:. 1989:. 1967:: 1946:. 1932:: 1911:. 1897:: 1876:. 1862:: 1841:. 1827:: 1806:. 1794:: 1777:. 1757:: 1749:: 1731:. 1719:: 1702:. 1688:: 1667:. 1653:: 1632:. 1618:: 1597:. 1583:: 1562:. 1548:: 1527:. 1507:: 1489:. 1469:: 1441:. 1419:: 1392:. 1370:: 1362:: 1356:9 1335:. 1313:: 1286:. 1272:. 1258:: 1226:. 1212:: 1185:. 1173:: 1150:. 1132:. 975:( 214:) 111:) 94::

Index

Aliases
NFKBIZ
OMIM
608004
MGI
1931595
HomoloGene
12734
GeneCards
NFKBIZ
OMA
NFKBIZ - orthologs
Human
Chromosome 3 (human)
Chr.
Chromosome 3 (human)
Chromosome 3 (human)
Genomic location for NFKBIZ
Genomic location for NFKBIZ
Band
bp
bp
Mouse
Chromosome 16 (mouse)
Chr.
Chromosome 16 (mouse)
Genomic location for NFKBIZ
Genomic location for NFKBIZ
Band
bp

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