581:
536:
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not known to the authors in time to be included in the article published in the
Journal on November 23, 2000. It now appears, however, from a memorandum dated July 5, 2000, that was obtained by subpoena in the Vioxx litigation and made available to the Journal, that at least two of the authors knew about the three additional myocardial infarctions at least two weeks before the authors submitted the first of two revisions and 4 1/2 months before publication of the article." During the five-year period between publication and Expression of Concern, it has been estimated that Merck paid
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3204:
781:—10 showed improvement by clinical and hematologic parameters after three months. In his article, Farber advised receiving the results cautiously: "It is again emphasized that these remissions are temporary in character and that the substance is toxic and may be productive of even greater disturbances than have been encountered so far in our studies," he wrote. "No evidence has been mentioned in this report that would justify the suggestion of the term 'cure' of acute leukemia in children."
237:
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1184:, the policy is intended to protect newsworthiness, and to subject research to peer review "before it is touted to the public or the profession". By 1991, four types of exceptions were recognized, including when "prepublication release of research conclusions is warranted because of immediate implications for the public health".
1295:
For research articles submitted before
February 1, 2024, NEJM makes the full-text Version of Record available at NEJM.org six months after publication. For research articles submitted on or after February 1, 2024, NEJM will provide authors with a PDF file of the Author Accepted Manuscript that may be
1291:
NEJM does not charge authors any submission or publication fees. NEJM also works with authors whose articles report research supported by funding bodies with open access mandates, including (but not limited to) Plan S funders and the U.S. government, including NIH, to ensure that authors are able to
1263:
published an expression of concern about the original study following discovery that the authors knew more about certain adverse events than they disclosed at the time of publication. From the
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1306:
features, one with interviews of doctors and researchers that are publishing in the journal, and another summarizing the content of each issue. Other offerings include
Continuing Medical Education, Videos in Clinical Medicine (showing videos of medical procedures), and the weekly Image Challenge.
919:
The site was launched several months earlier in 1996, but the editors wanted proof that weekly electronic publication would work. Only then was an announcement approved for publication on the editorial page. In 1997, the website included prepublication releases of certain articles prior to their
788:
published an early report on resuscitation of the heart. "The purpose of this report is to describe the successful use in 2 patients of a quick, simple, effective and safe method of arousing the heart from ventricular standstill by an artificial, external, electric pacemaker", he wrote. "For the
1287:
NEJM makes articles that meet the criteria for global and public health importance freely available to all readers upon publication at NEJM.org. NEJM also partners with
Research4Life in their Access to Research in Health (Hinari) program to grant to low-income countries immediate free access to
3253:
974:
had a 2017 impact factor of 79.258, ranking it first of 153 journals in the category "General & Internal
Medicine". It was the only journal in the category with an impact factor of more than 70. By comparison, the second and third ranked journals in the category
580:
724:. "A patient has been rendered completely insensible during an amputation of the thigh, regain consciousness after a short interval," Bigelow wrote. "Other severe operations have been performed without the knowledge of the patients."
850:, causes CML, the authors tested with success an inhibitor of this tyrosine kinase in patients who had failed first-line therapy. The finding helped begin the era of designing cancer drugs to target specific molecular abnormalities.
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Medical Cases, which mimic a clinical encounter by presenting the patient's history with results of the physical examination and laboratory and radiographic tests. Multiple-choice questions throughout test the taker's
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Farber, Sidney; Diamond, Louis K.; Mercer, Robert D.; Sylvester, Robert F.; et al. (1948). "Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-Aminopteroyl-Glutamic Acid (Aminopterin)".
1653:
In 1921, the journal merged with the Boston
Medical Intelligencer to become the Boston Medical and Surgical Journal; it also began weekly publication that year and was purchased by the Massachusetts Medical Society for $
894:
after six weeks. Significant doses of psilocybin were only administered twice in the six-week period, while escitalopram was taken daily. This was the first time psychedelics and SSRIs were compared in the treatment of
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as much as US$ 836,000 for article reprints that Merck used for promotional purposes. The journal was publicly rebuked for its response to the research issues in editorials appearing in publications including the
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in 1980 was later described by the journal as having been "heavily and uncritically cited" to claim that addiction due to use of opioids was rare, and its publication in such an authoritative journal was used by
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In
December 1981, two landmark articles described the clinical course of four patients—first reported in the CDC's June 1981 Morbidity and Mortality Weekly Report—with the disease that would come to be known as
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published over the course of a year. He found that many arrived at conclusions which were not supported by the evidence presented, or ignored easily available evidence that contradicted their conclusions.
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2184:
Carhart-Harris, Robin; Giribaldi, Bruna; Watts, Rosalind; Baker-Jones, Michelle; Murphy-Beiner, Ashleigh; Murphy, Roberta; Martell, Jonny; Blemings, Allan; Erritzoe, David; Nutt, David J. (2021-04-14).
2293:
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on the first public demonstration of a generalized anesthetic. The agent was inhaled ether, the first modern anesthetic. This allowed patients to remain sedated during operations ranging from
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2989:"Expression of Concern: Bombardier et al., "Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis," N Engl J Med 2000;343:1520-8"
535:
1010:
In 2022, NEJM set up a new sub-journal, NEJM Evidence. NEJM Evidence is a monthly digital journal featuring original research. It focuses on clinical trials and decision making.
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and introduced a procedure during screening to reduce cancer risk. The authors reported on 218 patients, from whom they removed 303 polyps (at one or more procedures per patient).
311:
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Lemmens, Trudo; Bouchard, Ron A. (2007). "Regulation of
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955:: "...provided the first significant mainstream visibility for a publication that would achieve enormous attention and prestige in the ensuing decades."
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Videos in Clinical Medicine, peer-reviewed educational videos to teach procedures requiring skilled techniques and specialized physical examination.
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has ever supported or condemned a political candidate and only three other times in history has an editorial been signed by all the editors.
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medical journals. Its 2023 impact factor was 96.2, ranking it 2nd out of 168 journals in the category "Medicine, General & Internal".
861:
saying that "they are dangerously incompetent" and that "they have taken a crisis and turned it into a tragedy." This is the first time
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Masur, Henry; Michelis, Mary Ann; Greene, Jeffrey B.; Onorato, Ida; et al. (1981). "An outbreak of community-acquired
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print publication. In 1998, online publication extended to include the full text of all its articles from 1993 forward.
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2548:"A history of journalistic integrity, superb reporting and protecting the public: The George Polk Awards in Journalism"
680:
1892:
Zoll, PM (November 1952). "Resuscitation of the heart in ventricular standstill by external electric stimulation".
1476:
676:
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2896:"Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis"
1377:
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1682:
Renamed to the New England Journal of Medicine in 1928, the journal is known for many firsts in medicine, ....
2294:"Could Psilocybin Treat Depression? New Head-To-Head Trial Shows It's At Least As Effective As Leading SSRI"
816:
3203:
2647:
False Positive: A Year of Error, Omission, and Political Correctness in the New England Journal of Medicine
2243:
2159:
1829:
Brown-Sequard, C.E.; Webber, S.G. (1872). "The origin and signification of the symptoms of brain disease".
995:
False Positive: A Year of Error, Omission, and Political Correctness in the New England Journal of Medicine
853:
In October 2020, the journal published an editorial, signed by all 34 editors, in which they condemned the
1316:
1230:
1127:
2111:"Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia"
1226:
1093:
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can influence both sides of the body. The neurologist would go on to describe what is now known as the
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1122:
211:
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790:
1557:
Garland, Joseph (1952). "The New England Journal of Medicineand the Massachusetts Medical Society".
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Gottlieb, Michael S.; Schroff, Robert; Schanker, Howard M.; Weisman, Joel D.; et al. (1981). "
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1081:
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Bigelow, Henry Jacob (1846). "Insensibility during surgical operations produced by inhalation".
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Campion, Edward W.; Miller, Pamela W.; Costello, Jean; Duff, Ellen; Drazen, Jeffrey M. (2010).
3192:
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lasting for hours to days. This procedure may prove valuable in many clinical situations."
773:, he worked on blocking folic acid metabolism. His team gave 16 infants and children with
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482:
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81:
1927:
Wolff, William I.; Shinya, Hiromi (1973). "Polypectomy via the fiberoptic colonoscope".
3094:
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Academic journals published by learned and professional societies of the United States
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1239:, concerns about the correctness of that study were raised with the journal's editor,
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2144:
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1225:. A study was published in the journal in November 2000 which noted an increase in
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2940:"NEJM "failed its readers" by delay in publishing its concerns about VIGOR trial"
2109:
Druker, Brian J.; Talpaz, Moshe; Resta, Debra J.; Peng, Bin; et al. (2001).
1135:
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New England Journal of Medicine and Surgery and Collateral Branches of Science
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as a medical and philosophical journal. Subsequently, the first issue of the
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1546:. Vol. 48. New England Historic Genealogical Society. pp. 148–149.
1462:
1222:
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785:
740:
712:
In November 1846, the New England Journal of Medicine published a report by
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1623:
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476:, along with James Jackson, submitted a formal prospectus to establish the
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2782:
2742:
2701:
2448:"The New England Journal of Medicine Celebrates 200th Anniversary in 2012"
2430:
2385:
2244:"Scientist compared psilocybin against antidepressants for the first time"
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2186:
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pneumonia and mucosal candidiasis in previously healthy homosexual men".
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1292:
meet their funders’ requirements for public access to research results.
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was involved in a controversy around problems with research on the drug
938:
NEJM Archive, the entire collection of the journal's published material.
2847:"Covid-19's impact on US medical research—shifting money, easing rules"
1303:
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pen. The dates on the logo represent the founding of the components of
517:
for US$ 1 (equivalent to $ 17 in 2023) and, in 1928, renamed it to
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2472:
McMahon, Graham T.; Ingelfinger, Julie R.; Campion, Edward W. (2006).
997:, he examines various articles on medical and social issues that the
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2987:
Curfman, Gregory D.; Morrissey, Stephen; Drazen, Jeffrey M. (2005).
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683:. Statements consisting only of original research should be removed.
484:
was published in January 1812. The journal was published quarterly.
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1259:
withdrew the drug from market in September 2004. In December 2005,
2160:"In a First, New England Journal of Medicine Joins Never-Trumpers"
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1143:
846:. Based on the knowledge that BCR-ABL, a constitutively activated
608:
260:
2798:"The Ingelfinger rule, embargoes, and journal peer review-part 1"
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750:
was published that proposed the then-revolutionary idea that one
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2618:"Journals Ranked by Impact: Medicine, General & Internal".
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3169:
MĂĽller, Daniel C.; Duff, Ellen M.C.; Stern, Kathy L. (2012).
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et al. demonstrated that in the pharmacological treatment of
456:. Founded in 1812, the journal is among the most prestigious
3171:"Timeline: 200 years of the New England Journal of Medicine"
506:
for $ 600 in 1828, merging the two publications to form the
1426:"Web of Science Master Journal List - WoS MJL by Clarivate"
1296:
deposited in a noncommercial repository after publication.
765:
reported promising results in treatment of early childhood
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first time it was possible to keep a patient alive during
3040:(3rd ed.). Toronto: LexisNexis Canada. p. 336.
513:
In 1921, the Massachusetts Medical Society purchased the
2187:"Trial of Psilocybin versus Escitalopram for Depression"
987:) had impact factors of 53.254 and 47.661 respectively.
916:
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2595:"Rank in Category: New England Journal of Medicine".
510:, and shifting from quarterly to weekly publication.
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The New England Historical and Genealogical Register
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published the first report of polyp removal using a
1964:"Addiction Rate in Patients Treated with Narcotics"
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2450:(Press release). Business Wire. January 12, 2012.
1450:
1243:, as early as August 2001. That year, both the US
236:
1399:"A journal stands out in prestige and longevity"
2004:"Opioid crisis: The letter that started it all"
111:The New England Journal of Medicine and Surgery
2669:
2667:
1453:Joseph Warren: Physician, Politician, Patriot
993:feels that this influence is unwarranted. In
603:The journal's logo depicts the snake-wrapped
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2715:Angell, Marcia; Kassirer, Jerome P. (1991).
2354:Kassirer, Jerome P.; Angell, Marcia (1997).
1491:"January 1, 1812, table of contents for the
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1800:"The origin and nature of the blood plates"
1249:Journal of the American Medical Association
735:with descriptions of what are now known as
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116:The New England Medical Review and Journal
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1229:amongst those taking Vioxx. According to
876:, there was no significant difference in
699:Learn how and when to remove this message
3249:1812 establishments in the United States
3074:Journal of the Royal Society of Medicine
1457:. Urbana: University of Illinois Press.
1276:Journal of the Royal Society of Medicine
1191:, "Definition of Sole Contribution", by
1831:The Boston Medical and Surgical Journal
1804:The Boston Medical and Surgical Journal
1765:The Boston Medical and Surgical Journal
1389:
1187:The rule was first described in a 1969
842:et al. reported a targeted therapy for
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121:The Boston Medical and Surgical Journal
2933:
2931:
1213:VIGOR study and publishing controversy
2474:"Videos in clinical medicine – A new
1744:Wood Library-Museum of Anesthesiology
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958:The journal usually has the highest
639:Notable articles from the course of
3224:The New England Journal of Medicine
3175:The New England Journal of Medicine
3065:The New England Journal of Medicine
2511:"Interactive medical cases – A new
1542:Fitz-Gilbert Waters, Henry (1894).
1219:The New England Journal of Medicine
1178:The New England Journal of Medicine
953:The New England Journal of Medicine
641:The New England Journal of Medicine
625:Boston Medical and Surgical Journal
613:The New England Journal of Medicine
588:The New England Journal of Medicine
573:Boston Medical and Surgical Journal
519:The New England Journal of Medicine
508:Boston Medical and Surgical Journal
491:, appeared under the editorship of
439:The New England Journal of Medicine
45:The New England Journal of Medicine
3154:Conaboy, Chelsea (June 17, 2012).
951:site noted that its 1977 award to
487:In 1823, another publication, the
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2757:"Definition of Sole Contribution"
1673:. New England Journal of Medicine
1644:. New England Journal of Medicine
1521:. New England Journal of Medicine
1397:Zuger, Abigail (March 19, 2012).
3274:Publications established in 1812
3217:
3202:
2717:"The Ingelfinger Rule Revisited"
2323:'s new presence on the internet"
1026:
653:
579:
564:
549:
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3131:. Massachusetts Medical Society
2993:New England Journal of Medicine
2938:Dobson, Roger (July 15, 2006).
2900:New England Journal of Medicine
2761:New England Journal of Medicine
2721:New England Journal of Medicine
2680:New England Journal of Medicine
2576:. Massachusetts Medical Society
2519:New England Journal of Medicine
2482:New England Journal of Medicine
2454:from the original on 2021-09-28
2409:New England Journal of Medicine
2364:New England Journal of Medicine
2327:New England Journal of Medicine
2191:New England Journal of Medicine
2158:Kolata, Gina (7 October 2020).
2115:New England Journal of Medicine
2076:New England Journal of Medicine
2037:New England Journal of Medicine
1968:New England Journal of Medicine
1929:New England Journal of Medicine
1894:New England Journal of Medicine
1859:New England Journal of Medicine
1704:New England Journal of Medicine
1602:New England Journal of Medicine
1559:New England Journal of Medicine
1087:NEJM Group (United States)
825:an addiction crisis in the U.S.
784:In November 1952, cardiologist
629:New England Journal of Medicine
3061:Smith, Richard (August 2006).
3038:Canadian Health Law and Policy
2405:'s Site on the World Wide Web"
2242:Sloat, Sarah (18 April 2021).
1667:"About NEJM: Past and Present"
1638:"About NEJM: Past and Present"
1598:from 1812 to 1989 at NEJM.org"
1515:"About NEJM: Past and Present"
746:In October 1872, a lecture by
1:
3156:"You've come a long way, doc"
2815:10.1016/s0140-6736(96)91016-8
2620:2014 Journal Citation Reports
2597:2017 Journal Citation Reports
1962:Porter, J.; Jick, H. (1980).
1203:have similar rules in place.
748:Charles-Édouard Brown-Séquard
454:Massachusetts Medical Society
146:Massachusetts Medical Society
36:Peer-reviewed medical journal
3259:Delayed open access journals
2845:Kardas-Nelson, Mara (2020).
1798:Wright, James Homer (1906).
1694:Kassirer, Jerome P. (1996).
1245:Food and Drug Administration
1207:Vioxx correction controversy
844:chronic myelogenous leukemia
775:acute lymphoblastic leukemia
621:Boston Medical Intelligencer
590:. First use of present name.
586:February 23, 1928, cover of
558:Boston Medical Intelligencer
541:January 1814 edition of the
489:Boston Medical Intelligencer
2913:10.1056/NEJM200011233432103
2774:10.1056/NEJM196909182811208
2734:10.1056/NEJM199111073251910
2693:10.1056/NEJM198110013051408
2422:10.1056/NEJM199808273390912
2399:Campion, Edward W. (1998).
2377:10.1056/NEJM199712113372409
2356:"Prepublication Release of
2340:10.1056/NEJM199604253341712
2317:Campion, Edward W. (1996).
2128:10.1056/NEJM200104053441401
2088:10.1056/NEJM198112103052402
2049:10.1056/NEJM198112103052401
1981:10.1056/NEJM198001103020221
1941:10.1056/NEJM197302152880701
1906:10.1056/NEJM195211132472005
1871:10.1056/NEJM194806032382301
1843:10.1056/NEJM187210170871601
1816:10.1056/NEJM190606071542301
1777:10.1056/NEJM184611180351601
1717:10.1056/NEJM199607043350110
1571:10.1056/NEJM195205222462101
1233:, the former editor of the
679:the claims made and adding
3290:
3086:10.1177/014107680609900802
2956:10.1136/bmj.333.7559.116-f
2674:Relman, Arnold S. (1981).
2650:. Encounter. p. 272.
2570:"Media Center: Fact Sheet"
1210:
1199:at that time. A number of
819:to push widespread use of
26:
3264:English-language journals
3164:(milestones of the NEJM).
3161:The Boston Globe Magazine
1159:
1025:
874:major depressive disorder
414:
51:
3269:General medical journals
1378:List of medical journals
968:Journal Citation Reports
817:pharmaceutical companies
777:a folic acid inhibitor,
526:Evolution of the Journal
27:Not to be confused with
1740:"History of Anesthesia"
1271:British Medical Journal
1236:British Medical Journal
927:has added to its site:
904:On April 25, 1996, the
3222:Quotations related to
2676:"The Ingelfinger Rule"
1317:Walter Prentice Bowers
1103:Standard abbreviations
756:Brown-SĂ©quard syndrome
192:Standard abbreviations
2796:Altman, L.K. (1996).
2767:(12): 676–677. 1969.
2401:"Improvements to the
2204:10.1056/NEJMoa2032994
1227:myocardial infarction
502:purchased the weekly
148: (United States)
3188:10.1056/NEJMp1114819
3125:"Editorial Policies"
2626:(Science ed.).
2603:(Science ed.).
2532:10.1056/NEJMe0809756
2072:Pneumocystis carinii
2033:Pneumocystis carinii
1615:10.1056/NEJMe1009367
1480:. September 28, 1811
1335:Franz J. Ingelfinger
1217:In the early 2000s,
880:effects between the
870:Robin Carhart-Harris
855:Trump administration
827:and other countries.
791:ventricular asystole
3006:10.1056/NEJMe058314
2808:(9012): 1382–1386.
2642:Dalrymple, Theodore
2495:10.1056/NEJMe068044
1449:Cary, John (1961).
1068:Publication details
1022:
966:. According to the
962:of the journals of
857:'s handling of the
752:cerebral hemisphere
714:Henry Jacob Bigelow
627:, and 1928 for the
498:The editors of the
474:John Collins Warren
468:In September 1811,
94:Publication details
48:
30:Journal of Medicine
2558:on March 28, 2010.
2164:The New York Times
1404:The New York Times
1347:Jerome P. Kassirer
1283:Open access policy
1006:Specialty journals
991:Theodore Dalrymple
949:George Polk Awards
923:Since its launch,
823:drugs, leading to
796:In February 1973,
729:James Homer Wright
664:possibly contains
493:Jerome V. C. Smith
173:Delayed (6 months)
2999:(26): 2813–2814.
2906:(21): 1520–1528.
2864:10.1136/bmj.m1744
2727:(19): 1371–1373.
2546:Hershey, Edward.
2370:(24): 1762–1763.
2292:Siebert, Amanda.
2197:(15): 1402–1411.
2121:(14): 1031–1037.
2082:(24): 1431–1438.
2043:(24): 1425–1431.
1608:(12): 1175–1176.
1430:mjl.clarivate.com
1359:Jeffrey M. Drazen
1193:Franz Ingelfinger
1170:
1169:
1062:Jeffrey M. Drazen
964:internal medicine
859:COVID-19 pandemic
810:published in the
718:dental extraction
709:
708:
701:
666:original research
452:published by the
435:
434:
16:(Redirected from
3281:
3235:
3234:
3232:Official website
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2559:
2554:. Archived from
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2500:
2499:
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2469:
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2149:
2148:
2130:
2106:
2100:
2099:
2067:
2061:
2060:
2028:
2022:
2021:
2019:
2017:
2000:
1994:
1993:
1983:
1959:
1953:
1952:
1924:
1918:
1917:
1889:
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1882:
1853:
1847:
1846:
1826:
1820:
1819:
1795:
1789:
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1754:
1753:
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1736:
1730:
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1650:
1649:
1634:
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1437:
1436:
1422:
1416:
1415:
1413:
1411:
1394:
1341:Arnold S. Relman
1323:Robert Nason Nye
1201:medical journals
1182:Ingelfinger rule
1173:Ingelfinger rule
1163:Journal homepage
1138:
1030:
1023:
1020:
1013:Academic journal
915:
882:psychedelic drug
704:
697:
693:
690:
684:
681:inline citations
657:
656:
649:
646:history include:
645:
635:Notable articles
605:Rod of Asclepius
583:
568:
553:
538:
418:Journal homepage
400:
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369:
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266:N. Engl. J. Med.
254:
253:New Eng. J. Med.
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183:
169:
102:
56:
49:
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39:Academic journal
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2755:
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2750:
2714:
2713:
2709:
2686:(14): 824–826.
2673:
2672:
2665:
2658:
2640:
2639:
2635:
2628:Thomson Reuters
2617:
2616:
2612:
2605:Thomson Reuters
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2274:. 14 April 2021
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2025:
2015:
2013:
2002:
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1997:
1961:
1960:
1956:
1926:
1925:
1921:
1900:(20): 768–771.
1891:
1890:
1886:
1865:(23): 787–793.
1855:
1854:
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1837:(16): 261–263.
1828:
1827:
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1797:
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1771:(16): 309–317.
1762:
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1197:editor-in-chief
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945:
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902:
868:In April 2021,
848:tyrosine kinase
838:In April 2001,
705:
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654:
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623:, 1828 for the
619:, 1823 for the
615:: 1812 for the
607:crossed over a
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2012:. June 3, 2017
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878:antidepressant
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761:In June 1948,
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737:megakaryocytes
727:In June 1906,
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1011:
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662:This article
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