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Guo J, Cagatay T, Zhou G, Chan CC, Blythe S, Suyama K, Zheng L, Pan K, Qian C, Hamelin R, Thibodeau SN, Klein PS, Wharton KA, Liu W. Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. PLoS One. 2009 Nov
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Yan D, Wallingford JB, Sun TQ, Nelson AM, Sakanaka C, Reinhard C, Harland RM, Fantl WJ, Williams LT. Cell autonomous regulation of multiple
Dishevelled-dependent pathways by mammalian Nkd. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):3802-7.
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Schneider I, Schneider PN, Derry SW, Lin S, Barton LJ, Westfall T, Slusarski DC. Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning. Dev Biol. 2010 Dec 1;348(1):22-33. Epub 2010 Sep 19.
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that disrupt Nkd1/Dvl binding implicate these mutations as a cause of increased Wnt signaling in a subset of human colon cancers, the majority of which have increased Wnt signaling due to mutations the
90:
Wharton KA Jr, Zimmermann G, Rousset R, Scott MP. Vertebrate proteins related to
Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. Dev Biol. 2001 Jun 1;234(1):93-106.
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Van Raay TJ, Coffey RJ, Solnica-Krezel L. Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling. Dev Biol. 2007 Sep 15;309(2):151-68. Epub 2007 Apr 21.
38:, in most vertebrates studied to date (zebrafish appear to have additional homologous genes such as Nkd3). Nkd1 binds to the
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Katoh M. Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2. Int J Oncol. 2001 Nov;19(5):963-9.
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31:
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27:
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34:. Insects typically have a single Nkd gene, whereas there are two Nkd genes, Nkd1 and
189:
72:
59:
39:
178:
161:
144:
128:
112:
95:
68:
26:) is a human gene that encodes the protein Nkd1, a member of the
51:
47:
43:
35:
54:). Specific truncating NKD1 mutations identified in
16:Protein-coding gene in the species Homo sapiens
8:
83:
30:family of proteins that regulate the
7:
14:
1:
212:
65:adenomatous polyposis coli
42:(Dvl) family of proteins (
32:Wnt signaling pathway
56:DNA mismatch repair
28:Naked cuticle (Nkd)
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71:, or rarely the
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173:24;4(11):e7982.
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20:Naked cuticle 1
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11:
5:
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196:Human proteins
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73:beta-catenin
60:colon cancer
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40:Dishevelled
58:deficient
190:Category
179:19956716
162:20858476
145:17689523
129:11604995
113:11274398
96:11356022
79:Sources
75:genes.
67:(APC),
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69:AXIN2
175:PMID
158:PMID
141:PMID
125:PMID
109:PMID
92:PMID
52:DVL3
48:DVL2
44:DVL1
36:Nkd2
24:NKD1
192::
50:,
46:,
22:(
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