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Neopterin concentrations usually correlate with the extent and activity of the disease, and are also useful to monitor during therapy in these patients. Elevated neopterin concentrations are among the best predictors of adverse outcome in patients with HIV infection, in cardiovascular disease and in
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Seizer L, Cornélissen-Guillaume G, Schiepek GK, Chamson E, Bliem HR and
Schubert C (2022) About-Weekly Pattern in the Dynamic Complexity of a Healthy Subject’s Cellular Immune Activity: A Biopsychosocial Analysis. Front. Psychiatry 13:799214. doi:
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Widner, Bernhard; Laich, Andreas; Sperner-Unterweger, Barbara; Ledochowski, Maximilian; Fuchs, Dietmar (2002). "Neopterin production, tryptophan degradation, and mental depression—What is the link?".
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Cavaleri et al. Blood concentrations of neopterin and biopterin in subjects with depression: A systematic review and meta-analysis. Progr
Neuropsychopharmacol Biol Psychiatry 2023;120:110633.
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Determination of neopterin and biopterin by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) in rat and human plasma, cell extracts and tissue homogenates (a protocol)
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Zeng B, et al. Serum neopterin for early assessment of severity of severe acute respiratory syndrome. Clin
Immunol 2005;116(1):18-26.
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Cavaleri et al. Blood concentrations of neopterin and biopterin in subjects with depression: A systematic review and meta-analysis
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Cavaleri et al. Blood concentrations of neopterin and biopterin in subjects with depression: A systematic review and meta-analysis
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Cavaleri et al. Blood concentrations of neopterin and biopterin in subjects with depression: A systematic review and meta-analysis
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Cavaleri et al. Blood concentrations of neopterin and biopterin in subjects with depression: A systematic review and meta-analysis
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Fuchs D, et al. The role of neopterin in atherogenesis and cardiovascular risk stratification. Curr Med Chem 2009;16:4644-4653.
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InChI=1S/C9H11N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h1,4,6,15-17H,2H2,(H3,10,11,13,14,18)/t4-,6+/m1/s1
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Adam, M. P.; Mirzaa, G. M.; Pagon, R. A.; Wallace, S. E.; Bean LJH; Gripp, K. W.; Amemiya, A.; Crow, Y. J. (1993).
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Roberston J, et al. Serum neopterin levels in relation to mild and severe COVID-19. BMC Infect Dis 2020;20(1):942.
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457:, which opens the ribose group. Phosphatases next catalyze the hydrolysis of the phosphate ester group.
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Murr C, et al. Neopterin as a marker for immune system activation. Curr Drug
Metabol 2002;3:175-187.
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of wavelength excitation at 353 nm and emission at 438 nm, rendering it readily detected.
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provides information about activation of cellular immune activation in humans under the control of
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Sucher R, et al. Neopterin, a prognostic marker in human malignancies. Cancer Lett 2010;287:13-22.
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Increased neopterin production is found in, but not limited to, the following diseases:
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and is indicative of a pro-inflammatory immune status. Neopterin serves as a marker of
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type 1. High neopterin production is associated with increased production of
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activation. In humans neopterin follows a circadian and circaseptan rhythm.
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Except where otherwise noted, data are given for materials in their
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Progress in Neuro-Psychopharmacology and
Biological Psychiatry
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Progress in Neuro-Psychopharmacology and
Biological Psychiatry
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Progress in Neuro-Psychopharmacology and
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Progress in Neuro-Psychopharmacology and
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Measurement of neopterin concentrations in body fluids like
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The biosynthesis of neopterin occurs in two steps from
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422:Neopterin belongs to the chemical group known as
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41:2-Amino-6-(1,2,3-trihydroxypropyl)pteridin-4(1
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763:. University of Washington, Seattle.
303:C1=C(N=C2C(=N1)NC(=NC2=O)N)C(C(CO)O)O
277:Key: BMQYVXCPAOLZOK-XINAWCOVSA-N
7:
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621:In the laboratory it is measured by
453:(GTP). The first being catalyzed by
415:belonging to the pteridine class of
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851:. You can help Knowledge (XXG) by
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298:O=C2\N=C(/Nc1ncc(nc12)(O)(O)CO)N
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370:(at 25 °C , 100 kPa).
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710:10.1016/s0889-1591(02)00006-5
698:Brain, Behavior, and Immunity
426:. It is synthesised by human
757:"Aicardi-Goutières Syndrome"
583:systemic lupus erythematosus
505:human immunodeficiency virus
461:Neopterin as disease marker
350:253.215 g/mol
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606:Aicardi-Goutieres syndrome
546:Mycobacterium tuberculosis
430:upon stimulation with the
686:10.3389/fpsyt.2022.799214
618:various types of cancer.
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529:by intracellular living
483:reactive oxygen species
451:guanosine triphosphate
439:cellular immune system
417:heterocyclic compounds
579:rheumatoid arthritis
527:Bacterial infections
37:Preferred IUPAC name
597:rejection episodes.
575:Autoimmune diseases
552:Helicobacter pylori
471:cerebrospinal fluid
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918:Biochemistry stubs
801:2023. 120:110633.
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455:GTP cyclohydrolase
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52:Identifiers
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761:GeneReviews
513:hepatitis C
509:hepatitis B
467:blood serum
428:macrophages
312:Properties
158:100.016.296
908:Pteridines
903:Immunology
898:Metabolism
892:Categories
637:References
611:Depression
564:Plasmodium
521:SARS-CoV-2
517:SARS-CoV-1
503:including
424:pteridines
360:2.02 g/cm
346:Molar mass
218:9PLD60N7SO
111:ChemSpider
80:3D model (
59:CAS Number
17:Neopterin
595:Allograft
581:(RA) and
559:parasites
409:Neopterin
176:Neopterin
69:2009-64-5
769:20301648
726:35800171
718:12401473
591:diseases
577:such as
561:such as
536:Borrelia
533:such as
531:bacteria
432:cytokine
131:DrugBank
625:(RIA),
604:called
569:malaria
507:(HIV),
390:what is
388: (
356:Density
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185:PubChem
140:DB02385
913:Triols
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549:, and
411:is an
385:verify
382:
291:SMILES
198:448839
120:395518
31:Names
843:This
722:S2CID
627:ELISA
585:(SLE)
475:urine
266:InChI
82:JSmol
45:)-one
849:stub
765:PMID
714:PMID
511:and
209:UNII
170:MeSH
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473:or
235:EPA
188:CID
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332:N
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