113:
The primary
Schwann cell differentiation and neoplastic proliferations are characteristics of peripheral nerve sheath tumors. For instance, the Schwann cell, which is the major neoplastic cell component of neurofibroma, is cytologically distinguished by the expression of S-100 protein and wavy
114:
nuclear outlines. A variety of peripheral nerve cells, including axons, perineurial cells, fibroblasts, and varying inflammatory components such as mast cells and lymphocytes, are also present in neurofibromas. A population of CD34-positive cells with an unknown histogenesis is also found.
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Slomiany MG, Dai L, Bomar PA, Knackstedt TJ, Kranc DA, Tolliver L, Maria BL, Toole BP. Abrogating drug resistance in malignant peripheral nerve sheath tumors by disrupting hyaluronan-CD44 interactions with small hyaluronan oligosaccharides. Cancer Res. 2009; 69:4992–4998.
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Perry A, Roth KA, Banerjee R, Fuller CE, Gutmann DH. NF1 deletions in S-100 protein-positive and negative cells of sporadic and neurofibromatosis 1 (NF1)-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors. Am J Pathol. 2001; 159:57–61.
64:. From benign tumors like schwannoma to high grade malignant neoplasms known as malignant peripheral nerve sheath tumors, peripheral nerve sheath tumors include a range of clearly characterized clinicopathologic entities. A
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Weiss SW, Langloss JM, Enzinger FM. Value of S-100 protein in the diagnosis of soft tissue tumors with particular reference to benign and malignant
Schwann cell tumors. Lab Invest. 1983; 49:299–308.
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Weiss SW, Nickoloff BJ. CD-34 is expressed by a distinctive cell population in peripheral nerve, nerve sheath tumors, and related lesions. Am J Surg Pathol. 1993; 17:1039–1045. [PubMed: 7690524]
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Louis, DN.; Ohgaki, H.; Wiestler, OD.; Cavenee, WK., editors. WHO Classification of
Tumours of the Central Nervous System. International Agency for Research on Cancer; Lyon: 2007.
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93:
438:
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803:
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Chaubal A, Paetau A, Zoltick P, Miettinen M. CD34 immunoreactivity in nervous system tumors. Acta
Neuropathol. 1994; 88:454–458.
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605:
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73:
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Carroll S. Molecular mechanisms promoting the pathogenesis of
Schwann cell neoplasms. Acta Neuropathol. 2012
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Note: Not all brain tumors are of nervous tissue, and not all nervous tissue tumors are in the brain (see
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443:
377:
745:
704:
428:
709:
519:
552:
658:
140:
729:
473:
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27:
781:
547:
621:
465:
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peripheral nerve sheath tumor, which are frequently resistant to conventional treatments.
590:
581:
511:
49:
32:
797:
699:
585:
501:
736:
724:
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85:
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595:
557:
423:
391:
343:
277:
145:
740:
653:
496:
81:
415:
363:
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141:"Spinal Cord Tumors -- Nerve Sheath Tumors (Schwannomas and Neurofibromas)"
233:
645:
488:
573:
406:
102:
77:
57:
265:
61:
45:
281:
769:
WHO classification of the tumors of the central nervous system
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761:
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510:
487:
464:
414:
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385:
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315:
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26:
21:
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8:
632:Embryonal tumour with multilayered rosettes
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402:
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321:
300:
286:
278:
224:
18:
109:Origin of peripheral nerve sheath tumors
753:Malignant peripheral nerve sheath tumor
677:Primary central nervous system lymphoma
601:Dysembryoplastic neuroepithelial tumour
123:
94:malignant peripheral nerve sheath tumor
80:peripheral nerve sheath tumors include
7:
56:) which is made up primarily of the
439:Subependymal giant cell astrocytoma
14:
72:) is a nerve sheath tumor in the
627:Atypical teratoid rhabdoid tumor
721:Cranial and paraspinal nerves
1:
434:Pleomorphic xanthoastrocytoma
309:Tumours of the nervous system
66:peripheral nerve sheath tumor
479:Anaplastic oligodendroglioma
820:
777:
74:peripheral nervous system
804:Nervous system neoplasia
606:Lhermitte–Duclos disease
530:Choroid plexus carcinoma
525:Choroid plexus papilloma
54:nervous system neoplasm
449:Anaplastic astrocytoma
444:Fibrillary astrocytoma
705:Esthesioneuroblastoma
429:Pilocytic astrocytoma
710:Ganglioneuroblastoma
615:CNS embryonal tumors
520:Choroid plexus tumor
553:Gliomatosis cerebri
717:Nerve sheath tumor
659:Hemangiopericytoma
42:nerve sheath tumor
22:Nerve sheath tumor
791:
790:
730:Neurofibromatosis
685:
684:
640:
639:
566:
565:
474:Oligodendroglioma
372:
371:
339:Craniopharyngioma
275:
274:
38:
37:
16:Medical condition
811:
782:brain metastasis
746:Acoustic neuroma
548:Oligoastrocytoma
541:Multiple/unknown
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663:
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622:Medulloblastoma
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466:Oligodendrocyte
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387:Neuroepithelial
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591:Retinoblastoma
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582:Ganglioneuroma
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512:Choroid plexus
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228:Classification
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220:External links
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50:nervous system
36:
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33:Neuro-oncology
30:
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2:
816:
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700:Neuroblastoma
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688:
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669:Hematopoietic
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586:Ganglioglioma
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575:
569:
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531:
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502:Subependymoma
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397:spinal tumors
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86:neurofibromas
83:
79:
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63:
59:
55:
51:
47:
44:is a type of
43:
34:
31:
29:
25:
20:
779:
737:Neurilemmoma
725:Neurofibroma
716:
454:Glioblastoma
392:brain tumors
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150:. Retrieved
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92:
90:
69:
65:
60:surrounding
41:
39:
596:Neurocytoma
558:Gliosarcoma
424:Astrocytoma
344:Pituicytoma
245:: 9540-9570
146:Mayo Clinic
82:schwannomas
741:Schwannoma
654:Meningioma
497:Ependymoma
152:2007-08-06
118:References
416:Astrocyte
364:Pinealoma
317:Endocrine
266:115242003
261:SNOMED CT
103:cancerous
28:Specialty
798:Category
646:Meninges
489:Ependyma
255:D018317
101:) is a
48:of the
574:neuron
571:Mature
407:Glioma
355:Other:
328:Sellar
78:Benign
62:nerves
58:myelin
762:Other
242:ICD-O
99:MPNST
46:tumor
250:MeSH
84:and
70:PNST
691:PNS
378:CNS
800::
784:).
584::
264::
253::
143:.
91:A
88:.
76:.
40:A
739:/
693::
399:)
394:,
390:(
330::
301:e
294:t
287:v
234:D
155:.
97:(
68:(
52:(
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