201:
190:
180:
The sequence of the C-terminal decapeptide is highly conserved across mammalian species: GNLWATGHFM-(NH2); this decapeptide is sometimes noted as neuromedin B, but it is more accurately described as neuromedin B 23-32. The sequence of neuromedin B (in rat) is: TPFSWDLPEPRSRASKIRVHPRGNLWATGHFM-(NH2).
262:
that is attached to the receptor is activated. The G-protein is called heterotrimeric because it consists of 3 polypeptides: α subunit, β subunit, and γ subunit. In the activated NMBR/G-protein complex, there occurs an exchange of
251:
with seven transmembrane spanning regions, hence the receptor is also denoted as a 7-transmembrane receptor (7-TMR). Upon binding several intracellular signaling pathways are triggered (see
295:. CRE is the control that activates number of growth factors, and thus cell proliferation and some anti-apoptotic genes. In the brain, CREB plays a role in long-term memory and learning.
405:"Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin"
356:"International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states"
1040:
37:
960:
586:
1075:
61:
49:
950:
42:
965:
579:
248:
985:
558:
259:
271:
bound to G-α subunit. The G-α subunit, in turn, dissociated form the G-βγ subunits. The free G-α inactivates
446:"Neuromedin B and gastrin-releasing peptide mRNAs are differentially distributed in the rat nervous system"
1080:
1035:
572:
264:
169:
165:
54:
268:
244:
107:
181:
The (NH2) here indicates a post-translational modification -- alpha amidation of the carboxy terminus.
1010:
1005:
995:
980:
288:
275:(AC), which, in turn, catalyzes the conversion of ATP to cAMP, the latter of which functioning as a
164:
in mammals. It was originally purified from pig spinal cord, and later shown to be present in human
837:
644:
669:
534:
336:
674:
613:
526:
475:
426:
385:
328:
291:, co-activator to the CRE region of the DNA in the nucleus. CREB and CBP are held together by
272:
516:
506:
465:
457:
416:
375:
367:
320:
280:
276:
219:
102:
1000:
725:
715:
131:
111:
554:
1020:
1015:
748:
743:
720:
622:
521:
494:
470:
461:
445:
380:
355:
292:
215:
421:
404:
324:
1069:
697:
692:
659:
538:
340:
1025:
901:
896:
891:
853:
848:
599:
78:
1030:
940:
868:
843:
779:
764:
684:
654:
639:
141:
511:
1045:
832:
796:
786:
769:
735:
707:
664:
85:
495:"Sneezing reflex is mediated by a peptidergic pathway from nose to brainstem"
970:
955:
801:
791:
774:
631:
530:
389:
332:
564:
479:
430:
403:
Krane IM, Naylor SL, Helin-Davis D, Chin WW, Spindel ER (September 1988).
200:
945:
924:
919:
863:
371:
157:
90:
990:
975:
595:
493:
Li F, Jiang H, Shen X, Yang W, Guo C, Wang Z, et al. (June 2021).
161:
911:
73:
824:
199:
188:
444:
Wada E, Way J, Lebacq-Verheyden AM, Battey JF (September 1990).
284:
243:
NMB acts by binding to its high affinity cell surface receptor,
189:
66:
568:
1050:
354:
Jensen RT, Battey JF, Spindel ER, Benya RV (March 2008).
933:
910:
879:
823:
814:
757:
734:
706:
683:
630:
621:
606:
137:
127:
122:
101:
96:
84:
72:
60:
48:
36:
28:
23:
18:
311:Ohki-Hamazaki H (October 2000). "Neuromedin B".
283:(PKA). PKA enters the nucleus and activates the
1041:Pituitary adenylate cyclase-activating peptide
211:Neuromedin regulates the following functions:
961:Cocaine- and amphetamine-regulated transcript
580:
287:protein. The activated CREB binds along with
8:
820:
627:
587:
573:
565:
119:
557:at the U.S. National Library of Medicine
520:
510:
469:
420:
379:
207: : Signal Cascade after NMB binding
303:
15:
7:
409:The Journal of Biological Chemistry
196:: NMB, 7-TMR receptor and G-protein
462:10.1523/JNEUROSCI.10-09-02917.1990
14:
258:When NMB binds to its 7-TMR, the
231:blood pressure and glucose level
951:Calcitonin gene-related peptide
279:. cAMP activates of the enzyme
1:
422:10.1016/S0021-9258(18)37707-X
325:10.1016/S0301-0082(00)00004-6
285:cAMP response element-binding
1076:Genes on human chromosome 15
966:Delta-sleep-inducing peptide
239:Neuromedin signaling pathway
450:The Journal of Neuroscience
247:(NMBR). This receptor is a
1097:
512:10.1016/j.cell.2021.05.017
249:G protein-coupled receptor
986:Gastrin-releasing peptide
118:
559:Medical Subject Headings
313:Progress in Neurobiology
260:heterotrimeric G protein
360:Pharmacological Reviews
1036:Pancreatic polypeptide
208:
197:
170:gastrointestinal tract
166:central nervous system
505:(14): 3762–3773.e10.
245:neuromedin B receptor
203:
192:
981:Galanin-like peptide
372:10.1124/pr.107.07108
289:CREB binding protein
209:
198:
1063:
1062:
1059:
1058:
810:
809:
273:adenylate cyclase
151:
150:
147:
146:
1088:
821:
628:
589:
582:
575:
566:
543:
542:
524:
514:
490:
484:
483:
473:
441:
435:
434:
424:
415:(26): 13317–23.
400:
394:
393:
383:
351:
345:
344:
308:
281:Protein Kinase A
277:second messenger
228:body temperature
120:
16:
1096:
1095:
1091:
1090:
1089:
1087:
1086:
1085:
1066:
1065:
1064:
1055:
1011:Neuropeptide VF
1006:Neuropeptide SF
1001:Neuropeptide FF
996:Neuropeptide AF
929:
906:
875:
816:
806:
753:
730:
702:
679:
648:
623:Opioid peptides
617:
602:
593:
551:
546:
492:
491:
487:
443:
442:
438:
402:
401:
397:
353:
352:
348:
310:
309:
305:
301:
293:leucine zippers
241:
187:
178:
12:
11:
5:
1094:
1092:
1084:
1083:
1078:
1068:
1067:
1061:
1060:
1057:
1056:
1054:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1021:Neuropeptide Y
1018:
1016:Neuropeptide S
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
937:
935:
931:
930:
928:
927:
922:
916:
914:
908:
907:
905:
904:
899:
894:
889:
883:
881:
877:
876:
874:
873:
872:
871:
866:
858:
857:
856:
851:
846:
835:
829:
827:
818:
812:
811:
808:
807:
805:
804:
799:
794:
789:
784:
783:
782:
772:
767:
761:
759:
755:
754:
752:
751:
749:Leu-enkephalin
746:
744:Met-enkephalin
740:
738:
732:
731:
729:
728:
723:
718:
712:
710:
704:
703:
701:
700:
695:
689:
687:
681:
680:
678:
677:
675:β-Neoendorphin
672:
670:α-Neoendorphin
667:
662:
657:
652:
651:
650:
646:
636:
634:
625:
619:
618:
610:
608:
604:
603:
594:
592:
591:
584:
577:
569:
563:
562:
550:
549:External links
547:
545:
544:
485:
456:(9): 2917–30.
436:
395:
346:
319:(3): 297–312.
302:
300:
297:
240:
237:
236:
235:
232:
229:
226:
223:
186:
183:
177:
174:
149:
148:
145:
144:
139:
135:
134:
129:
125:
124:
116:
115:
105:
99:
98:
94:
93:
88:
82:
81:
76:
70:
69:
64:
58:
57:
52:
46:
45:
40:
34:
33:
30:
26:
25:
21:
20:
13:
10:
9:
6:
4:
3:
2:
1093:
1082:
1081:Neuropeptides
1079:
1077:
1074:
1073:
1071:
1052:
1049:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1024:
1022:
1019:
1017:
1014:
1012:
1009:
1007:
1004:
1002:
999:
997:
994:
992:
989:
987:
984:
982:
979:
977:
974:
972:
969:
967:
964:
962:
959:
957:
954:
952:
949:
947:
944:
942:
939:
938:
936:
932:
926:
923:
921:
918:
917:
915:
913:
909:
903:
900:
898:
895:
893:
890:
888:
885:
884:
882:
878:
870:
867:
865:
862:
861:
859:
855:
852:
850:
847:
845:
842:
841:
839:
836:
834:
831:
830:
828:
826:
822:
819:
817:neuropeptides
813:
803:
800:
798:
795:
793:
790:
788:
785:
781:
778:
777:
776:
773:
771:
768:
766:
763:
762:
760:
756:
750:
747:
745:
742:
741:
739:
737:
733:
727:
724:
722:
719:
717:
714:
713:
711:
709:
705:
699:
698:Endomorphin-2
696:
694:
693:Endomorphin-1
691:
690:
688:
686:
682:
676:
673:
671:
668:
666:
663:
661:
660:Big dynorphin
658:
656:
653:
649:
643:
642:
641:
638:
637:
635:
633:
629:
626:
624:
620:
616:
615:
609:
605:
601:
600:neuropeptides
597:
590:
585:
583:
578:
576:
571:
570:
567:
560:
556:
553:
552:
548:
540:
536:
532:
528:
523:
518:
513:
508:
504:
500:
496:
489:
486:
481:
477:
472:
467:
463:
459:
455:
451:
447:
440:
437:
432:
428:
423:
418:
414:
410:
406:
399:
396:
391:
387:
382:
377:
373:
369:
365:
361:
357:
350:
347:
342:
338:
334:
330:
326:
322:
318:
314:
307:
304:
298:
296:
294:
290:
286:
282:
278:
274:
270:
266:
261:
256:
254:
250:
246:
238:
233:
230:
227:
224:
221:
217:
214:
213:
212:
206:
202:
195:
191:
184:
182:
175:
173:
171:
167:
163:
159:
155:
143:
140:
136:
133:
130:
126:
121:
117:
114:
113:
109:
106:
104:
100:
95:
92:
89:
87:
83:
80:
77:
75:
71:
68:
65:
63:
59:
56:
53:
51:
47:
44:
41:
39:
35:
31:
27:
22:
17:
1026:Neurophysins
886:
854:Neurokinin B
849:Neurokinin A
685:Endomorphins
611:
555:Neuromedin+B
502:
498:
488:
453:
449:
439:
412:
408:
398:
363:
359:
349:
316:
312:
306:
257:
252:
242:
210:
204:
193:
179:
154:Neuromedin B
153:
152:
110:
19:neuromedin B
1031:Neurotensin
941:Angiotensin
880:Neuromedins
869:Physalaemin
844:Substance P
838:Tachykinins
833:Bradykinins
780:Hemorphin-4
765:Adrenorphin
736:Enkephalins
726:γ-Endorphin
721:β-Endorphin
716:α-Endorphin
655:Dynorphin B
645:Dynorphin A
640:Dynorphin A
366:(1): 1–42.
225:cell growth
156:(NMB) is a
132:Swiss-model
24:Identifiers
1070:Categories
860:amphibian
797:Spinorphin
787:Nociceptin
770:Amidorphin
708:Endorphins
665:Leumorphin
632:Dynorphins
299:References
222:secretions
128:Structures
123:Search for
97:Other data
971:FMRFamide
956:Carnosine
840:: mammal
802:Valorphin
792:Opiorphin
775:Hemorphin
539:235430434
220:endocrine
160:-related
79:NM_021077
38:NCBI gene
946:Bombesin
864:Kassinin
614:hormones
607:Hormones
596:Peptides
531:34133943
390:18055507
341:23673653
333:10840151
253:Figure 2
234:sneezing
216:exocrine
205:Figure 2
194:Figure 1
185:Function
176:Sequence
158:bombesin
142:InterPro
112:q11-qter
1046:RVD-Hpα
991:Ghrelin
976:Galanin
912:Orexins
522:8396370
480:2398368
471:6570249
431:2458345
381:2517428
162:peptide
138:Domains
108:Chr. 15
86:UniProt
825:Kinins
758:Others
561:(MeSH)
537:
529:
519:
478:
468:
429:
388:
378:
339:
331:
91:P08949
74:RefSeq
67:162340
29:Symbol
934:Other
815:Other
535:S2CID
337:S2CID
103:Locus
612:see
527:PMID
499:Cell
476:PMID
427:PMID
386:PMID
329:PMID
267:for
218:and
168:and
62:OMIM
55:7842
50:HGNC
43:4828
1051:VGF
647:1–8
517:PMC
507:doi
503:184
466:PMC
458:doi
417:doi
413:263
376:PMC
368:doi
321:doi
269:GDP
265:GTP
255:).
32:NMB
1072::
598::
533:.
525:.
515:.
501:.
497:.
474:.
464:.
454:10
452:.
448:.
425:.
411:.
407:.
384:.
374:.
364:60
362:.
358:.
335:.
327:.
317:62
315:.
172:.
925:B
920:A
902:U
897:S
892:N
887:B
588:e
581:t
574:v
541:.
509::
482:.
460::
433:.
419::
392:.
370::
343:.
323::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
