156:
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Ripamonti, U; Duneas, N; Van Den Heever, B; Bosch, C; Crooks, J (1997). "Recombinant transforming growth factor-beta1 induces endochondral bone in the baboon and synergizes with recombinant osteogenic protein-1 (bone morphogenetic protein-7) to initiate rapid bone formation".
224:
The research for this method began in 1994 and included pre-clinical and clinical studies (in collaboration with universities) that finally culminated in a product that was patented in 2006. In 2012 the method was approved by the largest South
African medical aid
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Duneas, N; Crooks, J; Ripamonti, U (1998). "Transforming growth factor-beta 1: induction of bone morphogenetic protein genes expression during endochondral bone formation in the baboon, and synergistic interaction with osteogenic protein-1 (BMP-7)".
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and severe infections during surgery. Altis
Biologics developed a method to use pig bone which had been altered to make it human compatible and also make it injectable, removing the need for surgery. The method is particularly suitable for use in
212:. Traditionally, when repairing a severe bone break involving a void, new bone is taken from the hip and donated to the required site. This results in permanent disfigurement of the hip and complications such as hip displacement, buttock
229:) and since then more than 1000 patients have been implanted with the bone graft. The tissue used in the bone grafts is manufactured in South Africa, removing the previous need to import bone graft material from the USA and Europe.
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Ripamonti, U; Bosch, C; van den Heever, B; Duneas, N; Melsen, B; Ebner, R (1996). "Limited chondro-osteogenesis by recombinant human transforming growth factor-beta 1 in calvarial defects of adult baboons (Papio ursinus)".
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Recombinant transforming growth factor-beta1 induces endochondral bone in the baboon and synergizes with recombinant osteogenic protein-1 (bone morphogenetic protein-7) to initiate rapid bone formation. (October
287:
Transforming growth factor-beta 1: induction of bone morphogenetic protein genes expression during endochondral bone formation in the baboon, and synergistic interaction with osteogenic protein-1 (BMP-7).
814:
Mohangi, GU; Rothman, B; van Zyl, AW; Duneas, N (2012). "Enhanced activity of demineralised bone matrix augmented with xenogeneic bone morphogenetic protein complex in rats".
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Physicochemical modification of kafirin microparticles and their ability to bind bone morphogenetic protein-2 (BMP-2), for application as a biomaterial. (August 29, 2012)
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843:"Physicochemical modification of kafirin microparticles and their ability to bind bone morphogenetic protein-2 (BMP-2), for application as a biomaterial"
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Limited chondro-osteogenesis by recombinant human transforming growth factor-beta 1 in calvarial defects of adult baboons (Papio ursinus). (July 1996)
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Sibiya, SJ; Olivier, EI; Duneas, N (2013). "High yield isolation of BMP-2 from bone and in vivo activity of a combination of BMP-2/TGF-β1".
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Enhanced activity of demineralised bone matrix augmented with xenogeneic bone morphogenetic protein complex in rats. (2012 August)
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Synergistic
Interactions of Bone Morphogenetic Protein and Transforming Growth Factor-β in Bone Induction and Regeneration
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for the Altis
Osteogenic Bone Matrix. This was the first injectable treatment for injuries requiring bone grafts using a
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From 2008 until 2010, Duneas also served as managing director of Altis
Biologics. He has remained CEO since 2002.
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Ripamonti, U; Duneas, N (1998). "Tissue morphogenesis and regeneration by bone morphogenetic proteins".
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of Altis
Biologics. The company developed the first injectable treatment for bone injuries that require
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High yield isolation of BMP-2 from bone and in vivo activity of a combination of BMP-2/TGF-β1.(2012)
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537:"Dr Nic Duneas Discusses Bone Regeneration Technologies From Africa - YouTube"
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Dr Nic Duneas
Discusses Bone Regeneration Technologies From Africa
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Tissue
Engineering of Bne, From Concept To Market (April 2, 2008)
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478:"BioScience Bounty: Africa's Emerging Geography of Ideas"
202:. Duneas was appointed CEO of Altis Biologics in 2002.
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Anyango, JO; Duneas, N; Taylor, JR; Taylor, J (2012).
752:"Altis Biologics (Pty) Ltd TISSUE ENGINEERING OF BONE"
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324:"Innovation Prize for Africa (IPA) 2015 now open"
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235:In 2014, Duneas was interviewed by Alec Hogg for
447:Gaylard, Alison; Urban, Boris (6 March 2016).
271:. Duneas and Pires received US$ 100 000.
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385:"Altis Biologics | The Innovation Hub"
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16:South African biochemist (born 1972)
543:. IT News Africa. 19 September 2017
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730:10.1097/00006534-199801000-00040
569:. 1 August 2014. Archived from
173:University of the Witwatersrand
43:University of the Witwatersrand
476:Looney, William (March 2015).
383:Mpondo, Pulane (3 July 2017).
1:
906:Google Scholar (South Africa)
420:"Nicolaas Duneas - AngelList"
131:. He is the co-founder (with
961:South African businesspeople
816:South African Dental Journal
651:10.1359/jbmr.1997.12.10.1584
350:"Altis Biologics (PTY) Ltd"
257:Innovation Prize for Africa
179:from WITS. He also holds a
34:1972 (age 51–52)
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695:10.3109/08977199809017482
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966:South African scientists
515:The Rational Perspective
485:Pharmaceutical Executive
237:The Rational Perspective
205:The company focusses on
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239:(hosted on BizNews) on
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159:X-ray of spinal fusion
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781:J Biomed Mater Res A
251:In 2014, Duneas and
151:Education and career
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185:faculty of medicine
120:is a South African
389:The innovation hub
163:Duneas received a
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567:CNBC Africa
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267:biological
214:anaesthesia
143:by using a
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871:2263/19896
308:References
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200:Nuno Pires
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126:osteogenic
122:biochemist
263:-derived
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