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of the proteins in myelin, the protein MAL, during her doctoral studies at ETH Zurich. Later work in her own research group at the
Department of Biomedicine of the University of Basel, Schaeren-Wiemers showed that MAL is responsible for the apical transport in the myelin sheath. Later studies showed that the function of MAL is crucial for the association of the paranodal loops of the myelin sheaths at the axon with the membrane proteins myelin-associated glycoprotein, peripheral myelin protein 22kD, and nectin like 4. As an example, without MAL the paranodel loops lose contact with the axon. Nicole Schaeren-Wiemers research group characterized that these proteins are altered in humans with CMT1A and in the corresponding animal model. Nicole Schaeren-Wiemers also investigates the molecular changes in the normal appearing white matter (the myelinated axons) of deceased people with multiple sclerosis. Nicole Schaeren-Wiemers discovered that in normal appearing white matter many neuroprotective proteins are highly regulated. The research group of Schaeren-Wiemers was able to develop a suitable animal model.
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over 500 habilitated and adjunct professors. In 2013, the members of Group II founded the
Association of Lecturers at the University of Basel (DOZUBA), of which Schaeren-Wiemers was the first president. This was a result of the evaluation and performance assessment obligation at all university levels. In the following years, Schaeren-Wiemers managed that a member Group II was given a seat on every Regenz Commission. From 2009 to 2021, Schaeren-Wiemers also organized the elections for a member of Group II for various university committees and was in direct contact with the Rectorate (DOZUBA website). The major goal of DOZUBA is being included in the university statutes; that was achieved by Schaeren-Wiemers at the end of 2020. From 2015 to 2021, she was an elected member of Grouping II of the Faculty of Medicine in the Regenz and was also elected to the Regenz Committee as a representative of all members of Grouping II of the university.
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Network of Basel (NNB). This consists of the three faculties (Medicine, Natural
Sciences and Psychology), the University Hospital and the UPK, the FMI, the IOB and Neurex as well as the pharmaceutical industry are associated with the NNB. NNB is a scientific network, which enhance the neuroscience in Basel and is involved in the education of master as well as PhD students. The University of Basel contributed substantially in this network, which allows to organize each year the Brain Awareness Week (BAW) Brainweek, a public event.
407:. Switzerland. After completing her doctorate In 1995, she joined the Friedrich Miescher Institute (FMI) in Basel, Switzerland as a postdoctoral fellow. Schaeren-Wiemers was Research Group Leader at the Department of Biomedicine at the University of Basel, where she has been researching and teaching as a neurobiologist. In 2004, Schaeren-Wiemers obtained her Habilitation at the Medical Faculty of the University of Basel and in 2007, she was appointed to adjunct professor of neurobiology.
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Schaeren-Wiemers was member of the council of the Swiss
Society of Neuroscience (SSN) from 2009 to 2010, vice president from 2007 to 2009 and president from 2009 to 2010. Schaeren-Wiemers professionalized the neuroscience community of Switzerland. From 2013 to 2021, she was Chair of the Neuroscience
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Schaeren-Wiemers investigates the development of the myelin sheath and its preservation and compares it with that in mice, rats and humans. Myelin appears in evolution only in quadrupeds and is conserved structurally as well as at the molecular level including humans. Schaeren-Wiemers identified one
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From 2020 to 2021, Schaeren-Wiemers became Vice Dean for the promotion of young scientists at the
Faculty of Medicine. On 1 August 2021 Schaeren-Wiemers became Head of the newly created Vice-Rectorate People & Culture. Due to health reason, Schaeren-Wiemers had to step down in 2022, but proceed
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From 2013 to 2021, Schaeren-Wiemers was a member of the
Science Award Commission of the City of Basel. This commission consist of two members of each faculty and awards every year the “price of science of the city of Basel”. In 2022 Schaeren-Wiemers became member of the evaluation committee of the
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From 2011 to 2021, Schaeren-Wiemers was a member of the Equal
Opportunities Commission and was involved in improving the advancement of women in their scientific career. Schaeren-Wiemers was able to contribute to the university's strategy report (2022-2030) in this regard and bring about a binding
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From 2009 to 2021, Schaeren-Wiemers coordinated the Group II (habilitated and adjunct professors) of the
Faculty of Medicine and was elected as member of the Faculty Committee from 2009 to 2021. She played a key role in drawing up and updating the list of members of Group II, which now consists of
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The DBM's
Scientific Advisory Board had taken Schaeren-Wiemers as the coordinator of doctoral students at the DBM, which is enrolled at the Faculty of Natural Sciences. She established the "International PhD Program in Biomedicine", which is affiliated with the Faculty of Natural Sciences.
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Frank, Marcus; Schaeren-Wiemers, Nicole; Schneider, Regula; Schwab, Martin E. (1999). "Developmental
Expression Pattern of the Myelin ProteolipiMAL Indicates Different Functions of MAL for Immature Schwann Cells and in a Late Step of CNS Myelinogenesis".
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Zeis, T.; Allaman, I.; Gentner, M.; Schroder, K.; Tschopp, J.; Magistretti, P.J.; Schaeren-Wiemers, N. (2015). "Metabolic gene expression changes in astrocytes in Multiple Sclerosis cerebral cortex are indicative of immune-mediated signaling".
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Schaeren-Wiemers, Nicole; Gerfin-Moser, Andrea (1993). "A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: In situ hybridization using digoxigenin-labelled cRNA probes".
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Enz, Lukas Simon; Zeis, Thomas; Schmid, Daniela; Geier, Florian; Van Der Meer, Franziska; Steiner, Guido; Certa, Ulrich; Binder, Thomas Martin Christian; Stadelmann, Christine; Martin, Roland; Schaeren-Wiemers, Nicole (2020).
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Erne, B.; Sansano, S.; Frank, M.; Schaeren-Wiemers, N. (2002). "Rafts in adult peripheral nerve myelin contain major structural myelin proteins and myelin and lymphocyte protein (MAL) and CD59 as specific markers".
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Buser, A. M.; Schmid, D.; Kern, F.; Erne, B.; Lazzati, T.; Schaeren-Wiemers, N. (2009). "The myelin protein MAL affects peripheral nerve myelination: A new player influencing p75 neurotrophin receptor expression".
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Zeis, T.; Howell, O.W.; Reynolds, R.; Schaeren-Wiemers, N. (2018). "Molecular pathology of Multiple Sclerosis lesions reveals a heterogeneous expression pattern of genes involved in oligodendrogliogenesis".
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Schaeren-Wiemers, N.; Schaefer, C.; Valenzuela, D. M.; Yancopoulos, G. D.; Schwab, M. E. (1995). "Identification of New Oligodendrocyte- and Myelin-Specific Genes by a Differential Screening Approach".
395:(born 23 June 1962 in Basel) is a Swiss neurobiologist with a focus on myelin. She is research group leader at the Department of Research (DBM) and lecturer for neurobiology at the University of Basel.
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Kinter, Jochen; Lazzati, Thomas; Schmid, Daniela; Zeis, Thomas; Erne, Beat; LĂĽtzelschab, Roland; Steck, Andreas J; Pereyson, Davide; Peles, Elior; Schaeren-Wiemers, Nicole (2013-01-01).
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Zeis, T.; Graumann, U.; Reynolds, R.; Schaeren-Wiemers, N. (2007). "Normal-appearing white matter in multiple sclerosis is in a subtle balance between inflammation and neuroprotection".
219:
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Schaeren-Wiemers, Nicole; Bonnet, Annick; Erb, Michael; Erne, Beat; Bartsch, Udo; Kern, Frances; Mantei, Ned; Sherman, Diane; Suter, Ueli (2004-08-30).
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1230:"Molecular changes in normal appearing white matter in multiple sclerosis are characteristic of neuroprotective mechanisms against hypoxic insult"
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Caduff, J.; Sansano, S.; Bonnet, A.; Suter, U.; Schaeren-Wiemers, N. (2001). "Characterization of GFP-MAL expression and incorporation in rafts".
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Enz, Lukas Simon; Winkler, Anne; Wrzos, Claudia; Dasen, Boris; Nessler, Stefan; Stadelmann, Christine; Schaeren-Wiemers, Nicole (2023-09-09).
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507:"MAL Overexpression Leads to Disturbed Expression of Genes That Influence Cytoskeletal Organization and Differentiation of Schwann Cells"
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Enz, Lukas Simon; Winkler, Anne; Wrzos, Claudia; Dasen, Boris; Nessler, Stefan; Stadelmann, Christine; Schaeren-Wiemers, Nicole (2023).
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Zeis, Thomas; Probst, Alfonse; Steck, Andreas Johann; Stadelmann, Christine; BrĂĽck, Wolfgang; Schaeren-Wiemers, Nicole (2009).
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1132:"The raft-associated protein MAL is required for maintenance of proper axon--glia interactions in the central nervous system"
712:"Characterization of a rat gene, rMAL, encoding a protein with four hydrophobic domains in central and peripheral myelin"
669:"RMAL is a Glycosphingolipid-Associated Protein of Myelin and Apical Membranes of Epithelial Cells in Kidney and Stomach"
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1279:"An Animal Model for Chronic Meningeal Inflammation and Inflammatory Demyelination of the Cerebral Cortex"
971:"Molecular Changes in White Matter Adjacent to an Active Demyelinating Lesion in Early Multiple Sclerosis"
822:"An Animal Model for Chronic Meningeal Inflammation and Inflammatory Demyelination of the Cerebral Cortex"
462:"Theophylline Induces Remyelination and Functional Recovery in a Mouse Model of Peripheral Neuropathy"
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Duman, Mert; Jaggi, Stephanie; Enz, Lukas Simon; Jacob, Claire; Schaeren-Wiemers, Nicole (2022).
1181:"An essential role of MAG in mediating axon-myelin attachment in Charcot-Marie-Tooth 1A disease"
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Nicole Schaeren-Wiemers research group at the Department of Research at the University of Basel
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Graumann, Ursula; Reynolds, Richard; Steck, Andreas J; Schaeren-Wiemers, Nicole (2003-10-01).
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Frank, Marcus; Van Der Haar, Marjan E.; Schaeren-Wiemers, Nicole; Schwab, Martin E. (1998).
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city of Basel for financial support for young scientist from developed country.
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Schmid, Daniela; Zeis, Thomas; Sobrio, Monia; Schaeren-Wiemers, Nicole (2014).
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Schaeren-Wiemers, N.; Valenzuela, DM; Frank, M.; Schwab, ME (1995).
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1088:"ResearchGate Profile, Nicole Schaeren-Wiemers"
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1283:International Journal of Molecular Sciences
826:International Journal of Molecular Sciences
53:Learn how and when to remove these messages
1330:swissneuroscience.ch, Retrieved 2024-01-30
1067:"Curriculum vitae Nicole Schaeren-Wiemers"
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214:by replacing them with more appropriate
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768:10.1046/j.1471-4159.1995.65010010.x
1246:10.1111/j.1750-3639.2003.tb00485.x
728:10.1523/JNEUROSCI.15-08-05753.1995
685:10.1523/JNEUROSCI.18-13-04901.1998
652:10.1046/j.1471-4159.1999.0730587.x
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1341:"Nicole Schaeren-Wiemers resigns"
610:Microscopy Research and Technique
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987:10.1111/j.1750-3639.2008.00231.x
593:10.1046/j.1471-4159.2002.00987.x
563:10.1111/j.1460-9568.2009.06785.x
551:European Journal of Neuroscience
195:may rely excessively on sources
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420:Professional career and mission
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814:Research on multiple sclerosis
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382:H. Eppendorf and M. Schwab
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756:Journal of Neurochemistry
640:Journal of Neurochemistry
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341:Research in Neurobiology
284:Schaeren-Wiemers in 2013
1185:Neurobiology of Disease
1108:"PhD thesis ETH ZĂĽrich"
393:Nicole Schaeren-Wiemers
272:Nicole Schaeren-Wiemers
1069:. biomedizin.unibas.ch
912:Experimental Neurology
89:Please help by adding
1296:10.3390/ijms241813893
1148:10.1083/jcb.200406092
839:10.3390/ijms241813893
449:Selected publications
1026:10.1093/brain/awm291
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16:Swiss neurobiologist
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1361:Categories
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1093:2023-11-30
1073:2023-11-30
1054:References
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367:ETH ZĂĽrich
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228:March 2024
212:improve it
202:verifiable
158:March 2024
128:newspapers
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216:citations
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