642:
619:
994:
31:
3497:
1465:
1425:
1382:
1342:
1302:
871:
In
October 2019, the indication for niraparib was expanded to include people with advanced ovarian, fallopian tube, or primary peritoneal cancer treated with three or more prior chemotherapy regimens and whose cancer is associated with homologous recombination deficiency (HRD)-positive status. HRD is
879:
In the
European Union, niraparib is indicated: as monotherapy for the maintenance treatment of adults with advanced epithelial (FIGO Stages III and IV) high-grade ovarian, fallopian tube or primary peritoneal cancer who are in response (complete or partial) following completion of first-line
880:
platinum-based chemotherapy; and as monotherapy for the maintenance treatment of adults with platinum sensitive relapsed high grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in response (complete or partial) to platinum based chemotherapy.
875:
In April 2020, the indication for niraparib was expanded to include the maintenance treatment of adults with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to first-line platinum-based chemotherapy.
1060:
found that PARP inhibitors exhibit cytotoxic effects not based solely on their enzymatic inhibition of PARP, but by their trapping of PARP on damaged DNA, and the strength of this trapping activity was ordered niraparib >>
1677:
1659:
872:
defined by either a deleterious or suspected deleterious BRCA mutation, or genomic instability in patients with disease progression greater than six months after response to the last platinum-based chemotherapy.
266:
1319:
221:
1775:
1685:
119:
1442:
1032:
is 36 hours. 47.5% of the substance are found in the urine and 38.8% in the feces. Unmetabolised niraparib accounts for 11% in the urine and 19% in the feces.
2475:
1402:
732:
708:
1660:"Niraparib Receives FDA Fast Track Designation for the Treatment of Recurrent Platinum-Sensitive Ovarian, Fallopian Tube, or Primary Peritoneal Cancer"
760:
InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1
954:, but does not significantly inhibit them. Neither niraparib nor M1 significantly interact with any of the other important transporter proteins.
1272:
Text was copied from this source which is copyright
European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
3451:
1768:
1708:
3522:
3058:
1148:
2210:
2166:
2044:
932:
No clinical interaction studies have been performed. The potential for interactions with other drugs is low as niraparib and its main
1969:
752:
87:
1730:
1761:
1216:
2691:
2485:
408:
251:
151:
3104:
2106:
1996:
1009:
concentrations after about three hours, independently of food intake. In the circulation, 83% of the substance are bound to
3517:
3026:
3009:
2884:
2648:
2026:
3487:
2758:
2354:
1448:
1408:
1365:
1325:
1295:
1112:
1082:
510:
3468:
2960:
1753:
1359:
865:
598:
170:
1514:"14C-niraparib, a novel poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor, in patients with advanced cancer"
2140:
1742:
1320:"FDA approves maintenance treatment for recurrent epithelial ovarian, fallopian tube or primary peritoneal cancers"
1291:
3326:
3206:
3196:
1257:
1093:
861:
853:
3532:
3378:
3311:
3281:
2899:
2149:
837:(high blood pressure), back pain, dizziness, cough, joint pain, hot flushes and decrease in white blood cells.
1108:. Patients without such a mutation had a PFS of 9.3 months under niraparib versus 3.9 months under placebo.
3456:
3363:
3181:
2896:
2382:
2230:
2157:
207:
637:
3261:
3251:
2984:
2826:
1078:
783:
587:
341:
1089:
in 2016. It was approved on 27 March 2017 in the US, and approved in
European Union on 16 November 2017.
3527:
2533:
2350:
2320:
2180:
857:
849:
786:
used for the treatment of epithelial ovarian, fallopian tube, or primary peritoneal cancer. It is taken
3537:
2931:
2808:
2329:
2245:
1124:
1086:
1029:
377:
614:
3216:
3116:
3095:
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2638:
2470:
2201:
2097:
787:
425:
214:
2274:
181:
3423:
2304:
2284:
2269:
840:
Niraparib was approved for medical use in the United States and in the
European Union in 2017.
567:
3398:
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1806:
1641:
1592:
1543:
913:
499:
304:
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101:
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897:
802:
719:
654:
356:
323:
48:
1561:
van Andel L, Rosing H, Zhang Z, Hughes L, Kansra V, Sanghvi M, et al. (January 2018).
1252:
519:
3501:
2842:
2804:
2595:
2017:
1932:
1120:
1018:
998:
937:
641:
618:
369:
351:
331:
1610:
Murai J, Huang SY, Das BB, Renaud A, Zhang Y, Doroshow JH, et al. (November 2012).
1512:
van Andel L, Zhang Z, Lu S, Kansra V, Agarwal S, Hughes L, et al. (December 2017).
3462:
2996:
2587:
2081:
1945:
1832:
1802:
1789:
1636:
1611:
1587:
1562:
1538:
1513:
1022:
1010:
968:
947:
791:
3511:
3336:
3296:
2666:
2539:
2420:
2363:
2121:
2070:
1469:
1429:
1386:
1346:
1306:
1153:
1097:
630:
459:
143:
993:
924:), 15% of patients had to permanently discontinue niraparib due to adverse effects.
3383:
3347:
3231:
3221:
3175:
3171:
3133:
3041:
2831:
2770:
2766:
2747:
2742:
2721:
2710:
2524:
2518:
2504:
2499:
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2425:
2378:
2264:
2131:
2111:
2040:
1989:
1979:
1793:
1785:
1006:
917:
834:
810:
234:
229:
1627:
1485:
129:
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3408:
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3301:
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3211:
3155:
3128:
3001:
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2552:
2403:
2388:
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2185:
2171:
2126:
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2054:
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2006:
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1917:
1880:
1857:
1842:
1837:
1822:
1176:
1128:
1045:
905:
818:
137:
3418:
3321:
3316:
3291:
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3166:
3121:
3109:
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3079:
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2785:
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2446:
2435:
2408:
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2154:
2086:
2076:
2065:
2049:
2001:
1984:
1960:
1912:
1900:
1852:
1578:
1529:
933:
908:(in 30%, severe in 20%). Other, mostly mild to moderate side effects included
684:
490:
363:
3433:
3413:
3368:
3358:
3352:
3256:
3201:
3150:
3074:
3064:
3019:
2947:
2909:
2837:
2775:
2716:
2705:
2661:
2618:
2577:
2571:
2567:
2529:
2456:
2451:
2441:
2413:
2373:
2334:
2309:
2299:
2259:
1905:
1895:
1890:
1885:
1847:
1066:
1057:
390:
123:
1645:
1596:
1547:
896:
The most common side effects in studies were low blood cell counts, namely
22:
3342:
3306:
3246:
3014:
2952:
2732:
2628:
2600:
2279:
2116:
1177:"Zejula 100 mg hard capsules - Summary of Product Characteristics (SmPC)"
1104:
was 21.0 months under niraparib therapy, as compared to 5.5 months under
1101:
1062:
1041:
1005:
73% of ingested niraparib is absorbed in the gut, and it reaches highest
942:
826:
822:
814:
470:
165:
479:
2235:
2136:
1950:
1811:
1443:"FDA approves niraparib for first-line maintenance of advanced ovarian"
1105:
830:
445:
30:
1875:
1709:"Tesaro's PARP ovarian cancer drug hits PhIII goal; prepares to file"
921:
909:
901:
806:
798:
578:
547:
539:
1488:. American Society of Health-System Pharmacists. 22 September 2020
992:
982:
978:
707:
698:
558:
1468:
This article incorporates text from this source, which is in the
1428:
This article incorporates text from this source, which is in the
1403:"FDA approves niraparib for HRD-positive advanced ovarian cancer"
1385:
This article incorporates text from this source, which is in the
1345:
This article incorporates text from this source, which is in the
1305:
This article incorporates text from this source, which is in the
951:
888:
No contraindications are listed in the prescribing information.
530:
310:
285:
1757:
1096:(PFS) for patients with a deleterious or suspected deleterious
298:
160:
603:
936:
M1 do not significantly interact with any of the important
260:
192:
69:
1612:"Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors"
1563:"14C-microtracer and therapeutic dose in cancer patients"
821:(low levels of neutrophils, a type of white blood cell),
75:
63:
54:
273:
852:
for the maintenance treatment of adults with recurrent
3485:
805:(low blood platelet counts), tiredness and weakness,
88:
51:
78:
72:
66:
60:
3143:
3094:
2874:
2867:
2803:
2757:
2690:
2647:
2484:
2469:
2349:
2319:
2244:
2229:
2200:
2096:
2016:
1959:
1942:
1931:
1867:
1820:
1801:
825:(difficulty sleeping), headache, lack of appetite,
718:
696:
683:
653:
648:
629:
597:
577:
557:
529:
509:
489:
469:
444:
424:
399:
389:
376:
362:
350:
340:
330:
322:
250:
245:
220:
206:
180:
150:
136:
118:
110:
100:
57:
42:
37:
1211:
1209:
1207:
1205:
1203:
1201:
1199:
1197:
1664:The European Society for Medical Oncology (ESMO)
458:
1040:The drug is used in form of the salt niraparib
433:
1397:
1395:
1044:monohydrate, which is white to off-white, non-
1769:
1247:
1245:
1243:
1241:
1239:
1237:
8:
1149:"Summary Basis of Decision (SBD) for Zejula"
1115:(FDA) granted the application for niraparib
169:
21:
946:. Niraparib, but not M1, is transported by
864:who are in complete or partial response to
2871:
2481:
2241:
1956:
1939:
1817:
1776:
1762:
1754:
640:
617:
498:
29:
1635:
1586:
1537:
969:PARP inhibitor § Mechanism of action
518:
1507:
1505:
1503:
740:c1cc2cn(nc2c(c1)C(=O)N)c3ccc(cc3)4CCCNC4
3492:
1486:"Niraparib Monograph for Professionals"
1480:
1478:
1140:
997:The inactive main metabolite M1 is the
757:
737:
613:
478:
413:
142:
631:
20:
1286:
1284:
1282:
1280:
1278:
900:(in 61% of patients, severe in 29%),
797:The most common side effects include
586:
566:
128:
7:
1567:Cancer Chemotherapy and Pharmacology
920:. In a study running over 250 days (
233:
2045:ribonucleotide reductase inhibitors
1684:. 17 September 2018. Archived from
546:
538:
449:
2211:Ribonucleotide reductase inhibitor
2167:Ribonucleotide reductase inhibitor
1021:derivative, which is subsequently
14:
1970:Dihydrofolate reductase inhibitor
3495:
1743:"Niraparib tosylate monohydrate"
1731:"Niraparib tosylate monohydrate"
1463:
1423:
1380:
1340:
1300:
671:
665:
47:
1360:"Drug Trials Snapshots: Zejula"
1017:to the main metabolite M1, the
765:Key:PCHKPVIQAHNQLW-CQSZACIVSA-N
416:2-phenyl]indazole-7-carboxamide
2107:Thymidylate synthase inhibitor
1997:Thymidylate synthase inhibitor
1330:(Press release). 27 March 2017
1092:In a study with 553 patients,
1085:(FDA), and Tesaro submitted a
677:
659:
1:
2027:Adenosine deaminase inhibitor
1868:Block microtubule disassembly
1628:10.1158/0008-5472.CAN-12-2753
809:(low red blood cell counts),
1737:. National Cancer Institute.
1449:Food and Drug Administration
1409:Food and Drug Administration
1366:Food and Drug Administration
1326:Food and Drug Administration
1296:Food and Drug Administration
1113:Food and Drug Administration
1083:Food and Drug Administration
904:(in 50%, severe in 25%) and
778:, sold under the brand name
1217:"Zejula- niraparib capsule"
866:platinum-based chemotherapy
3554:
3523:Drugs developed by GSK plc
966:
817:, abdominal (belly) pain,
649:Chemical and physical data
3446:
3327:Omacetaxine mepesuccinate
3207:Ciltacabtagene autoleucel
3197:Brexucabtagene autoleucel
1747:National Cancer Institute
1682:European Medicines Agency
1579:10.1007/s00280-017-3455-x
1530:10.1007/s10637-017-0451-2
1518:Investigational New Drugs
1258:European Medicines Agency
1094:progression-free survival
862:primary peritoneal cancer
748:
728:
404:
28:
3379:Talimogene laherparepvec
3312:Nadofaragene firadenovec
3282:Lisocabtagene maraleucel
2231:Topoisomerase inhibitors
2150:DNA polymerase inhibitor
1707:Adams B (29 June 2016).
1001:derivative of niraparib.
833:(difficulty breathing),
3182:Axicabtagene ciloleucel
1786:chemotherapeutic agents
1013:. It is inactivated by
281: / Schedule D
3364:Sitimagene ceradenovec
3262:Idecabtagene vicleucel
2827:Methyl aminolevulinate
1079:fast track designation
1077:Niraparib was granted
1002:
784:anti-cancer medication
16:Anti-cancer medication
2838:Porphyrin derivatives
2534:Melphalan flufenamide
2181:Hypomethylating agent
1790:antineoplastic agents
1298:(FDA). 30 March 2017.
996:
967:Further information:
3518:Indazolecarboxamides
3167:Asparagine depleters
3096:Receptor antagonists
3010:+abiraterone acetate
1292:"Niraparib (Zejula)"
1125:breakthrough therapy
1087:new drug application
1030:biological half-life
395:48% urine, 29% feces
3217:Denileukin diftitox
3117:Retinoid X receptor
2817:Aminolevulinic acid
2639:Triethylenemelamine
2471:Crosslinking of DNA
2202:Deoxyribonucleotide
2141:+gimeracil/oteracil
1735:NCI Drug Dictionary
1666:. 5 September 2016.
1262:. 17 September 2018
963:Mechanism of action
720:Solubility in water
294:(Prescription only)
269:(Prescription only)
25:
3473:Never to phase III
2275:Etirinotecan pegol
1056:A 2012 study in a
1003:
854:epithelial ovarian
3483:
3482:
3442:
3441:
3399:Tigilanol tiglate
2876:Enzyme inhibitors
2799:
2798:
2795:
2794:
2495:Nitrogen mustards
2465:
2464:
2225:
2224:
1927:
1926:
1413:. 23 October 2019
1157:. 23 October 2014
1015:carboxylesterases
884:Contraindications
773:
772:
709:Interactive image
599:CompTox Dashboard
357:Carboxylesterases
314:
302:
289:
276:
264:
196:
163:
3545:
3500:
3499:
3498:
3491:
3404:Tisagenlecleucel
3161:Arsenic trioxide
2872:
2805:Photosensitizers
2596:Alkyl sulfonates
2510:Cyclophosphamide
2482:
2421:Anthracenediones
2242:
2216:Hydroxycarbamide
1957:
1940:
1818:
1778:
1771:
1764:
1755:
1750:
1749:. 14 April 2017.
1738:
1717:
1716:
1704:
1698:
1697:
1695:
1693:
1688:on 9 August 2018
1674:
1668:
1667:
1656:
1650:
1649:
1639:
1607:
1601:
1600:
1590:
1558:
1552:
1551:
1541:
1509:
1498:
1497:
1495:
1493:
1482:
1473:
1467:
1466:
1462:
1460:
1458:
1439:
1433:
1427:
1426:
1422:
1420:
1418:
1399:
1390:
1384:
1383:
1379:
1377:
1375:
1356:
1350:
1344:
1343:
1339:
1337:
1335:
1316:
1310:
1304:
1303:
1299:
1288:
1273:
1271:
1269:
1267:
1249:
1232:
1231:
1229:
1227:
1213:
1192:
1191:
1189:
1187:
1173:
1167:
1166:
1164:
1162:
1145:
989:Pharmacokinetics
973:Niraparib is an
898:thrombocytopenia
803:thrombocytopenia
801:(feeling sick),
711:
691:
679:
673:
667:
661:
644:
633:
622:
621:
607:
605:
590:
570:
550:
542:
522:
502:
482:
462:
452:
451:
437:
381:
312:
309:
300:
297:
287:
284:
275:
272:
262:
259:
237:
194:
191:
173:
162:
159:
146:
132:
92:
85:
84:
81:
80:
77:
74:
71:
68:
65:
62:
59:
56:
53:
33:
26:
24:
3553:
3552:
3548:
3547:
3546:
3544:
3543:
3542:
3533:PARP inhibitors
3508:
3507:
3506:
3496:
3494:
3486:
3484:
3479:
3478:
3463:Clinical trials
3438:
3144:Other/ungrouped
3139:
3090:
2863:
2843:Porfimer sodium
2791:
2753:
2686:
2643:
2473:
2461:
2345:
2315:
2233:
2221:
2196:
2092:
2012:
1948:
1946:antimetabolites
1944:
1943:DNA precursors/
1935:
1933:DNA replication
1923:
1863:
1833:Vinca alkaloids
1809:
1797:
1782:
1741:
1729:
1726:
1721:
1720:
1706:
1705:
1701:
1691:
1689:
1676:
1675:
1671:
1658:
1657:
1653:
1622:(21): 5588–99.
1616:Cancer Research
1609:
1608:
1604:
1560:
1559:
1555:
1511:
1510:
1501:
1491:
1489:
1484:
1483:
1476:
1464:
1456:
1454:
1453:. 29 April 2020
1441:
1440:
1436:
1424:
1416:
1414:
1401:
1400:
1393:
1381:
1373:
1371:
1370:. 27 March 2017
1358:
1357:
1353:
1341:
1333:
1331:
1318:
1317:
1313:
1301:
1290:
1289:
1276:
1265:
1263:
1251:
1250:
1235:
1225:
1223:
1215:
1214:
1195:
1185:
1183:
1175:
1174:
1170:
1160:
1158:
1147:
1146:
1142:
1137:
1121:priority review
1075:
1054:
1038:
1019:carboxylic acid
1011:plasma proteins
999:carboxylic acid
991:
977:of the enzymes
971:
965:
960:
938:cytochrome P450
930:
894:
886:
846:
769:
766:
761:
756:
755:
744:
741:
736:
735:
714:
689:
676:
670:
664:
625:
601:
593:
573:
553:
525:
505:
485:
465:
448:
440:
420:
417:
412:
411:
379:
370:carboxylic acid
342:Protein binding
332:Bioavailability
324:Pharmacokinetic
318:
241:
209:
202:
183:
176:
90:
86:
50:
46:
17:
12:
11:
5:
3551:
3549:
3541:
3540:
3535:
3530:
3525:
3520:
3510:
3509:
3505:
3504:
3481:
3480:
3477:
3476:
3475:
3474:
3471:
3460:
3454:
3448:
3447:
3444:
3443:
3440:
3439:
3437:
3436:
3431:
3426:
3421:
3416:
3411:
3406:
3401:
3396:
3391:
3386:
3381:
3376:
3371:
3366:
3361:
3356:
3350:
3339:
3334:
3329:
3324:
3319:
3314:
3309:
3304:
3299:
3294:
3289:
3284:
3279:
3274:
3269:
3264:
3259:
3254:
3249:
3244:
3239:
3234:
3229:
3224:
3219:
3214:
3209:
3204:
3199:
3194:
3189:
3184:
3179:
3163:
3158:
3153:
3147:
3145:
3141:
3140:
3138:
3137:
3125:
3113:
3100:
3098:
3092:
3091:
3089:
3088:
3082:
3077:
3072:
3067:
3055:
3049:
3044:
3039:
3034:
3023:
3017:
3012:
3004:
2997:PARP inhibitor
2993:
2981:
2969:
2957:
2956:
2955:
2950:
2945:
2940:
2928:
2922:
2917:
2912:
2907:
2893:
2880:
2878:
2869:
2865:
2864:
2862:
2861:
2855:
2850:
2845:
2834:
2829:
2824:
2819:
2813:
2811:
2801:
2800:
2797:
2796:
2793:
2792:
2790:
2789:
2783:
2778:
2773:
2763:
2761:
2755:
2754:
2752:
2751:
2745:
2740:
2729:
2724:
2719:
2714:
2702:
2696:
2694:
2688:
2687:
2685:
2684:
2679:
2674:
2669:
2664:
2659:
2653:
2651:
2649:Platinum-based
2645:
2644:
2642:
2641:
2636:
2631:
2626:
2614:
2613:
2607:
2591:
2590:
2585:
2580:
2575:
2565:
2560:
2548:
2547:
2542:
2537:
2527:
2522:
2516:
2507:
2502:
2490:
2488:
2479:
2467:
2466:
2463:
2462:
2460:
2459:
2454:
2449:
2444:
2439:
2433:
2428:
2417:
2411:
2406:
2401:
2396:
2391:
2386:
2376:
2371:
2364:Anthracyclines
2359:
2357:
2347:
2346:
2344:
2343:
2337:
2325:
2323:
2317:
2316:
2314:
2313:
2307:
2302:
2297:
2292:
2287:
2282:
2277:
2272:
2267:
2262:
2250:
2248:
2239:
2227:
2226:
2223:
2222:
2220:
2219:
2206:
2204:
2198:
2197:
2195:
2194:
2188:
2176:
2175:
2162:
2161:
2145:
2144:
2134:
2129:
2124:
2119:
2114:
2102:
2100:
2094:
2093:
2091:
2090:
2084:
2082:Mercaptopurine
2073:
2068:
2063:
2057:
2052:
2036:
2035:
2022:
2020:
2014:
2013:
2011:
2010:
2004:
1993:
1987:
1982:
1977:
1965:
1963:
1954:
1937:
1929:
1928:
1925:
1924:
1922:
1921:
1909:
1903:
1898:
1893:
1888:
1883:
1871:
1869:
1865:
1864:
1862:
1861:
1855:
1850:
1845:
1840:
1828:
1826:
1815:
1799:
1798:
1784:Intracellular
1783:
1781:
1780:
1773:
1766:
1758:
1752:
1751:
1739:
1725:
1724:External links
1722:
1719:
1718:
1713:Fierce Biotech
1699:
1669:
1651:
1602:
1553:
1524:(6): 751–765.
1499:
1474:
1434:
1391:
1351:
1311:
1274:
1233:
1193:
1168:
1139:
1138:
1136:
1133:
1131:designations.
1074:
1071:
1053:
1050:
1037:
1034:
1023:glucuronidated
990:
987:
964:
961:
959:
956:
948:P-glycoprotein
940:liver enzymes
929:
926:
893:
890:
885:
882:
858:fallopian tube
845:
842:
792:PARP inhibitor
771:
770:
768:
767:
764:
762:
759:
751:
750:
749:
746:
745:
743:
742:
739:
731:
730:
729:
726:
725:
722:
716:
715:
713:
712:
704:
702:
694:
693:
687:
681:
680:
674:
668:
662:
657:
651:
650:
646:
645:
635:
627:
626:
624:
623:
615:DTXSID50146129
610:
608:
595:
594:
592:
591:
583:
581:
575:
574:
572:
571:
563:
561:
555:
554:
552:
551:
545:as salt:
543:
535:
533:
527:
526:
524:
523:
515:
513:
507:
506:
504:
503:
495:
493:
487:
486:
484:
483:
475:
473:
467:
466:
464:
463:
455:
453:
442:
441:
439:
438:
430:
428:
422:
421:
419:
418:
415:
407:
406:
405:
402:
401:
397:
396:
393:
387:
386:
383:
374:
373:
366:
360:
359:
354:
348:
347:
344:
338:
337:
334:
328:
327:
320:
319:
317:
316:
307:
295:
282:
270:
256:
254:
248:
247:
243:
242:
240:
239:
226:
224:
218:
217:
212:
210:administration
204:
203:
201:
200:
198:
188:
186:
178:
177:
175:
174:
156:
154:
148:
147:
140:
134:
133:
126:
116:
115:
112:
108:
107:
104:
98:
97:
44:
40:
39:
35:
34:
15:
13:
10:
9:
6:
4:
3:
2:
3550:
3539:
3536:
3534:
3531:
3529:
3526:
3524:
3521:
3519:
3516:
3515:
3513:
3503:
3493:
3489:
3472:
3470:
3467:
3466:
3464:
3461:
3458:
3455:
3453:
3450:
3449:
3445:
3435:
3432:
3430:
3427:
3425:
3422:
3420:
3417:
3415:
3412:
3410:
3407:
3405:
3402:
3400:
3397:
3395:
3392:
3390:
3387:
3385:
3382:
3380:
3377:
3375:
3372:
3370:
3367:
3365:
3362:
3360:
3357:
3354:
3351:
3349:
3345:
3344:
3340:
3338:
3337:Tabelecleucel
3335:
3333:
3330:
3328:
3325:
3323:
3320:
3318:
3315:
3313:
3310:
3308:
3305:
3303:
3300:
3298:
3297:Lurbinectedin
3295:
3293:
3290:
3288:
3285:
3283:
3280:
3278:
3275:
3273:
3270:
3268:
3265:
3263:
3260:
3258:
3255:
3253:
3250:
3248:
3245:
3243:
3240:
3238:
3235:
3233:
3230:
3228:
3225:
3223:
3220:
3218:
3215:
3213:
3210:
3208:
3205:
3203:
3200:
3198:
3195:
3193:
3190:
3188:
3185:
3183:
3180:
3177:
3173:
3169:
3168:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3148:
3146:
3142:
3135:
3131:
3130:
3126:
3123:
3119:
3118:
3114:
3111:
3107:
3106:
3102:
3101:
3099:
3097:
3093:
3086:
3083:
3081:
3078:
3076:
3073:
3071:
3068:
3066:
3062:
3060:
3056:
3053:
3050:
3048:
3045:
3043:
3040:
3038:
3035:
3033:
3029:
3028:
3024:
3021:
3018:
3016:
3013:
3011:
3008:
3005:
3003:
2999:
2998:
2994:
2991:
2987:
2986:
2982:
2979:
2975:
2974:
2970:
2967:
2963:
2962:
2958:
2954:
2951:
2949:
2946:
2944:
2941:
2939:
2936:
2935:
2934:
2933:
2929:
2926:
2923:
2921:
2918:
2916:
2913:
2911:
2908:
2906:
2902:
2901:
2898:
2894:
2891:
2887:
2886:
2882:
2881:
2879:
2877:
2873:
2870:
2866:
2859:
2856:
2854:
2851:
2849:
2846:
2844:
2840:
2839:
2835:
2833:
2830:
2828:
2825:
2823:
2820:
2818:
2815:
2814:
2812:
2810:
2806:
2802:
2787:
2784:
2782:
2779:
2777:
2774:
2772:
2768:
2765:
2764:
2762:
2760:
2759:Intercalation
2756:
2749:
2746:
2744:
2741:
2739:
2735:
2734:
2730:
2728:
2725:
2723:
2720:
2718:
2715:
2712:
2708:
2707:
2703:
2701:
2698:
2697:
2695:
2693:
2689:
2683:
2680:
2678:
2675:
2673:
2670:
2668:
2667:Dicycloplatin
2665:
2663:
2660:
2658:
2655:
2654:
2652:
2650:
2646:
2640:
2637:
2635:
2632:
2630:
2627:
2625:
2622:
2620:
2616:
2615:
2611:
2608:
2606:
2602:
2599:
2597:
2593:
2592:
2589:
2586:
2584:
2581:
2579:
2576:
2573:
2569:
2566:
2564:
2561:
2559:
2556:
2554:
2550:
2549:
2546:
2543:
2541:
2540:Prednimustine
2538:
2535:
2531:
2528:
2526:
2523:
2520:
2517:
2515:
2511:
2508:
2506:
2503:
2501:
2498:
2496:
2492:
2491:
2489:
2487:
2483:
2480:
2477:
2472:
2468:
2458:
2455:
2453:
2450:
2448:
2445:
2443:
2440:
2437:
2434:
2432:
2429:
2427:
2423:
2422:
2418:
2415:
2412:
2410:
2407:
2405:
2402:
2400:
2397:
2395:
2392:
2390:
2387:
2384:
2380:
2377:
2375:
2372:
2370:
2366:
2365:
2361:
2360:
2358:
2356:
2355:Intercalation
2352:
2348:
2341:
2338:
2336:
2332:
2331:
2327:
2326:
2324:
2322:
2318:
2311:
2308:
2306:
2303:
2301:
2298:
2296:
2293:
2291:
2288:
2286:
2283:
2281:
2278:
2276:
2273:
2271:
2268:
2266:
2263:
2261:
2257:
2256:
2252:
2251:
2249:
2247:
2243:
2240:
2237:
2232:
2228:
2217:
2213:
2212:
2208:
2207:
2205:
2203:
2199:
2192:
2189:
2187:
2183:
2182:
2178:
2177:
2173:
2169:
2168:
2164:
2163:
2159:
2158:+daunorubicin
2156:
2152:
2151:
2147:
2146:
2142:
2138:
2135:
2133:
2130:
2128:
2125:
2123:
2122:Doxifluridine
2120:
2118:
2115:
2113:
2109:
2108:
2104:
2103:
2101:
2099:
2095:
2088:
2085:
2083:
2079:
2078:
2074:
2072:
2071:Rabacfosadine
2069:
2067:
2064:
2061:
2058:
2056:
2053:
2051:
2047:
2046:
2042:
2038:
2037:
2033:
2029:
2028:
2024:
2023:
2021:
2019:
2015:
2008:
2005:
2003:
1999:
1998:
1994:
1991:
1988:
1986:
1983:
1981:
1978:
1976:
1972:
1971:
1967:
1966:
1964:
1962:
1958:
1955:
1952:
1947:
1941:
1938:
1934:
1930:
1919:
1915:
1914:
1910:
1907:
1904:
1902:
1899:
1897:
1894:
1892:
1889:
1887:
1884:
1882:
1878:
1877:
1873:
1872:
1870:
1866:
1859:
1856:
1854:
1851:
1849:
1846:
1844:
1841:
1839:
1835:
1834:
1830:
1829:
1827:
1824:
1819:
1816:
1813:
1808:
1804:
1800:
1795:
1791:
1787:
1779:
1774:
1772:
1767:
1765:
1760:
1759:
1756:
1748:
1744:
1740:
1736:
1732:
1728:
1727:
1723:
1714:
1710:
1703:
1700:
1687:
1683:
1679:
1673:
1670:
1665:
1661:
1655:
1652:
1647:
1643:
1638:
1633:
1629:
1625:
1621:
1617:
1613:
1606:
1603:
1598:
1594:
1589:
1584:
1580:
1576:
1572:
1568:
1564:
1557:
1554:
1549:
1545:
1540:
1535:
1531:
1527:
1523:
1519:
1515:
1508:
1506:
1504:
1500:
1487:
1481:
1479:
1475:
1471:
1470:public domain
1452:
1450:
1444:
1438:
1435:
1431:
1430:public domain
1412:
1410:
1404:
1398:
1396:
1392:
1388:
1387:public domain
1369:
1367:
1361:
1355:
1352:
1348:
1347:public domain
1329:
1327:
1321:
1315:
1312:
1308:
1307:public domain
1297:
1293:
1287:
1285:
1283:
1281:
1279:
1275:
1261:
1259:
1254:
1253:"Zejula EPAR"
1248:
1246:
1244:
1242:
1240:
1238:
1234:
1222:
1218:
1212:
1210:
1208:
1206:
1204:
1202:
1200:
1198:
1194:
1182:
1178:
1172:
1169:
1156:
1155:
1154:Health Canada
1150:
1144:
1141:
1134:
1132:
1130:
1126:
1122:
1118:
1114:
1109:
1107:
1103:
1099:
1098:BRCA mutation
1095:
1090:
1088:
1084:
1080:
1072:
1070:
1068:
1064:
1059:
1051:
1049:
1047:
1043:
1035:
1033:
1031:
1026:
1024:
1020:
1016:
1012:
1008:
1000:
995:
988:
986:
984:
980:
976:
970:
962:
957:
955:
953:
949:
945:
944:
939:
935:
927:
925:
923:
919:
915:
911:
907:
903:
899:
891:
889:
883:
881:
877:
873:
869:
867:
863:
859:
855:
851:
848:Niraparib is
843:
841:
838:
836:
832:
828:
824:
820:
816:
812:
808:
804:
800:
795:
793:
789:
785:
781:
777:
763:
758:
754:
747:
738:
734:
727:
723:
721:
717:
710:
706:
705:
703:
700:
695:
688:
686:
682:
658:
656:
652:
647:
643:
639:
636:
634:
632:ECHA InfoCard
628:
620:
616:
612:
611:
609:
600:
596:
589:
588:ChEMBL1094636
585:
584:
582:
580:
576:
569:
565:
564:
562:
560:
556:
549:
544:
541:
537:
536:
534:
532:
528:
521:
517:
516:
514:
512:
508:
501:
497:
496:
494:
492:
488:
481:
477:
476:
474:
472:
468:
461:
457:
456:
454:
447:
443:
436:
432:
431:
429:
427:
423:
414:
410:
403:
398:
394:
392:
388:
384:
382:
375:
371:
367:
365:
361:
358:
355:
353:
349:
345:
343:
339:
335:
333:
329:
325:
321:
315: Rx-only
308:
306:
296:
293:
283:
280:
271:
268:
258:
257:
255:
253:
249:
244:
236:
231:
228:
227:
225:
223:
219:
216:
213:
211:
205:
199:
190:
189:
187:
185:
179:
172:
167:
158:
157:
155:
153:
149:
145:
141:
139:
135:
131:
127:
125:
121:
117:
113:
109:
105:
103:
99:
95:
94:
83:
45:
43:Pronunciation
41:
38:Clinical data
36:
32:
27:
19:
3528:Orphan drugs
3384:Tazemetostat
3348:Alitretinoin
3341:
3252:Estramustine
3232:Elsamitrucin
3222:Eflornithine
3176:Pegaspargase
3172:Asparaginase
3165:
3134:Testolactone
3127:
3115:
3103:
3057:
3042:Panobinostat
3025:
3006:
2995:
2983:
2971:
2959:
2930:
2895:
2883:
2836:
2832:Padeliporfin
2771:Dactinomycin
2767:Streptomyces
2748:Temozolomide
2743:Mitozolomide
2731:
2722:Mitobronitol
2711:Procarbazine
2704:
2692:Nonclassical
2617:
2594:
2588:Streptozocin
2553:Nitrosoureas
2551:
2525:Chlorambucil
2519:Trofosfamide
2505:Chlormethine
2500:Bendamustine
2493:
2431:Mitoxantrone
2426:Losoxantrone
2419:
2379:Daunorubicin
2362:
2328:
2265:Camptothecin
2253:
2209:
2179:
2165:
2148:
2132:Fluorouracil
2112:Capecitabine
2105:
2075:
2039:
2025:
1995:
1990:Pralatrexate
1980:Methotrexate
1968:
1911:
1874:
1831:
1746:
1734:
1712:
1702:
1690:. Retrieved
1686:the original
1681:
1672:
1663:
1654:
1619:
1615:
1605:
1573:(1): 39–46.
1570:
1566:
1556:
1521:
1517:
1490:. Retrieved
1455:. Retrieved
1446:
1437:
1415:. Retrieved
1406:
1372:. Retrieved
1363:
1354:
1332:. Retrieved
1323:
1314:
1264:. Retrieved
1256:
1224:. Retrieved
1220:
1184:. Retrieved
1180:
1171:
1159:. Retrieved
1152:
1143:
1110:
1091:
1076:
1055:
1039:
1027:
1007:blood plasma
1004:
972:
958:Pharmacology
941:
931:
928:Interactions
918:constipation
895:
892:Side effects
887:
878:
874:
870:
847:
844:Medical uses
839:
835:hypertension
811:constipation
796:
779:
775:
774:
568:CHEBI:176844
435:1038915-60-4
378:Elimination
252:Legal status
246:Legal status
152:License data
18:
3538:Piperidines
3459:from market
3429:Vorasidenib
3409:Trabectedin
3394:Tiazofurine
3389:Tebentafusp
3374:Tagraxofusp
3332:Plitidepsin
3302:Mitoguazone
3242:Epacadostat
3212:Demecolcine
3156:Aflibercept
3129:Sex steroid
3002:Fuzuloparib
2943:Carfilzomib
2915:Palbociclib
2905:Abemaciclib
2858:Verteporfin
2822:Efaproxiral
2738:Dacarbazine
2700:Altretamine
2682:Satraplatin
2677:Oxaliplatin
2657:Carboplatin
2634:Triaziquone
2605:Mannosulfan
2583:Ranimustine
2563:Fotemustine
2404:Pirarubicin
2389:Doxorubicin
2383:+cytarabine
2369:Aclarubicin
2330:Podophyllum
2255:Camptotheca
2186:Azacitidine
2172:Gemcitabine
2127:Floxuridine
2060:Fludarabine
2055:Clofarabine
2041:Halogenated
2032:Pentostatin
2007:Raltitrexed
1975:Aminopterin
1918:Ixabepilone
1913:Epothilones
1881:Cabazitaxel
1858:Vinorelbine
1843:Vincristine
1838:Vinblastine
1823:microtubule
1129:orphan drug
1046:hygroscopic
906:neutropenia
819:neutropenia
692: g·mol
638:100.210.548
400:Identifiers
364:Metabolites
138:MedlinePlus
111:Other names
102:Trade names
3512:Categories
3424:Verdinexor
3419:Venetoclax
3322:Oblimersen
3317:Navitoclax
3292:Lucanthone
3287:Lonidamine
3277:Lifileucel
3272:Ivosidenib
3267:Imetelstat
3237:Enasidenib
3227:Elesclomol
3192:Bexarotene
3187:Belzutifan
3122:Bexarotene
3110:Atrasentan
3085:Umbralisib
3080:Idelalisib
3070:Copanlisib
3052:Vorinostat
3047:Romidepsin
3037:Entinostat
3032:Belinostat
2990:Masoprocol
2978:Tiazofurin
2966:Anagrelide
2938:Bortezomib
2925:Seliciclib
2920:Ribociclib
2900:inhibitors
2890:Tipifarnib
2853:Temoporfin
2848:Talaporfin
2786:Plicamycin
2781:Mitomycins
2727:Pipobroman
2706:Hydrazines
2672:Nedaplatin
2624:Carboquone
2619:Aziridines
2610:Treosulfan
2558:Carmustine
2545:Uramustine
2514:Ifosfamide
2486:Alkylating
2447:Bisantrene
2436:Pixantrone
2409:Valrubicin
2399:Idarubicin
2394:Epirubicin
2340:Teniposide
2295:Lurtotecan
2290:Irinotecan
2191:Decitabine
2155:Cytarabine
2098:Pyrimidine
2087:Tioguanine
2077:Thiopurine
2066:Nelarabine
2050:Cladribine
2002:Pemetrexed
1985:Pemetrexed
1961:Folic acid
1901:Paclitaxel
1853:Vinflunine
1492:17 January
1457:17 January
1417:17 January
1374:17 January
1334:17 January
1266:17 January
1226:17 January
1186:17 January
1135:References
1117:fast track
1081:by the US
1048:crystals.
934:metabolite
790:. It is a
697:3D model (
685:Molar mass
520:HMC2H89N35
491:ChemSpider
426:CAS Number
409:IUPAC name
352:Metabolism
3469:Phase III
3457:Withdrawn
3434:Vosaroxin
3414:Veliparib
3369:Sotorasib
3359:Selinexor
3353:Tretinoin
3343:Retinoids
3257:Glasdegib
3202:Celecoxib
3151:Adagrasib
3075:Duvelisib
3065:Alpelisib
3020:Rucaparib
3007:Niraparib
2948:Oprozomib
2910:Alvocidib
2776:Bleomycin
2733:Triazenes
2717:Etoglucid
2662:Cisplatin
2578:Nimustine
2572:Semustine
2568:Lomustine
2530:Melphalan
2457:Menogaril
2452:Crisnatol
2442:Amsacrine
2414:Zorubicin
2374:Amrubicin
2335:Etoposide
2310:Topotecan
2305:Silatecan
2300:Rubitecan
2285:Gimatecan
2270:Cositecan
2260:Belotecan
1936:inhibitor
1906:Tesetaxel
1896:Ortataxel
1891:Larotaxel
1886:Docetaxel
1848:Vindesine
1067:veliparib
1065:>>
1058:cell line
1036:Chemistry
1028:The mean
975:inhibitor
850:indicated
776:Niraparib
391:Excretion
380:half-life
208:Routes of
182:Pregnancy
171:Niraparib
130:Monograph
124:Drugs.com
23:Niraparib
3502:Medicine
3307:Mitotane
3247:Eribulin
3015:Olaparib
2953:Ixazomib
2629:Thiotepa
2601:Busulfan
2280:Exatecan
2117:Carmofur
1825:assembly
1788: /
1678:"Zejula"
1646:23118055
1597:29043410
1548:28303528
1221:DailyMed
1102:germline
1063:olaparib
1042:tosylate
943:in vitro
827:diarrhea
823:insomnia
815:vomiting
788:by mouth
782:, is an
500:24531930
471:DrugBank
460:24958200
385:36 hours
222:ATC code
215:By mouth
184:category
166:DailyMed
2236:S phase
2137:Tegafur
1951:S phase
1876:Taxanes
1812:M phase
1637:3528345
1588:5754411
1539:5694528
1294:. U.S.
1111:The US
1106:placebo
1100:in the
1073:History
1052:Studies
914:fatigue
831:dyspnea
724:0.7–1.1
690:320.396
655:Formula
480:DB11793
446:PubChem
277::
238:)
232: (
230:L01XK02
197: D
168::
144:a617007
114:MK-4827
93:-uh-rib
3488:Portal
3452:WHO-EM
3061:(Pi3K)
2018:Purine
1821:Block
1692:29 May
1644:
1634:
1595:
1585:
1546:
1536:
1161:29 May
1127:, and
922:median
916:, and
910:nausea
902:anemia
807:anemia
799:nausea
780:Zejula
733:SMILES
579:ChEMBL
548:D11895
540:D10140
305:℞-only
303:
290:
279:℞-only
265:
164:
106:Zejula
96:
2973:IMPDI
2868:Other
1451:(FDA)
1447:U.S.
1411:(FDA)
1407:U.S.
1368:(FDA)
1364:U.S.
1328:(FDA)
1324:U.S.
1260:(EMA)
1181:(emc)
983:PARP2
979:PARP1
860:, or
753:InChI
699:JSmol
559:ChEBI
3059:PIKI
3027:HDAC
2476:CCNS
1694:2018
1642:PMID
1593:PMID
1544:PMID
1494:2021
1459:2021
1419:2021
1376:2021
1336:2021
1268:2021
1228:2021
1188:2021
1163:2022
981:and
952:BCRP
950:and
531:KEGG
511:UNII
368:M1 (
326:data
120:AHFS
89:nih-
3105:ERA
2961:PhI
2932:PrI
2897:CDK
2809:PDT
1807:MIs
1803:SPs
1794:L01
1632:PMC
1624:doi
1583:PMC
1575:doi
1534:PMC
1526:doi
604:EPA
450:CID
346:83%
336:73%
292:POM
235:WHO
91:RAP
3514::
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2985:LI
2885:FI
2351:II
2321:II
2143:))
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1516:.
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274:CA
267:S4
261:AU
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