Knowledge (XXG)

Carboxylesterase

Source đź“ť

2012: 580:
Holmes RS, Wright MW, Laulederkind SJ, Cox LA, Hosokawa M, Imai T, Ishibashi S, Lehner R, Miyazaki M, Perkins EJ, Potter PM, Redinbo MR, Robert J, Satoh T, Yamashita T, Yan B, Yokoi T, Zechner R, Maltais LJ (2010).
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Mentlein R, Schumann M, Heymann E (1984). "Comparative chemical and immunological characterization of five lipolytic enzymes (carboxylesterases) from rat liver microsomes".
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Aranda, Juan; Cerqueira, N. M. F. S. A.; Fernandes, P.A.; Roca, M.; Tuñon, I.; Ramos, M. J. (2014). "The Catalytic Mechanism of Carboxylesterases. A Computational Study".
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Horgan DJ, Stoops JK, Webb EC, Zerner B (1969). "Carboxylesterases (EC 3.1.1). A large-scale purification of pig liver carboxylesterase".
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Runnegar MT, Scott K, Webb EC, Zerner B (1969). "Carboxylesterases (EC 3.1.1). Purification and titration of ox liver carboxylesterase".
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Augusteyn RC, de Jersey J, Webb EC, Zerner B (1969). "On the homology of the active-site peptides of liver carboxylesterases".
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Carboxylesterases are widely distributed in nature, and are common in mammalian liver. Many participate in
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by other enzymes to increase solubility and eventually excreted. The essential polyunsaturated fatty acid
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An approved nomenclature has been established for the five mammalian carboxylesterase gene families.
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to each other) includes a number of proteins with different substrate specificities, such as
1820: 1815: 1789: 1717: 1555: 1135: 1040: 1035: 991: 851: 822: 780: 749: 741: 706: 673: 644: 602: 594: 529: 449: 316: 275: 1867: 1851: 1764: 1657: 1471: 1387: 1382: 1377: 1290: 1285: 1045: 923: 300: 99: 75: 2016: 1905: 1846: 1630: 1625: 1620: 1006: 981: 977: 950: 933: 754: 729: 711: 695:"Hydrolysis of vitamin A acetate by unspecific carboxylesterases from liver and kidney" 694: 607: 582: 283: 174: 34: 154: 2026: 1810: 1769: 1371: 1280: 1030: 826: 648: 347: 149: 1759: 1498: 1429: 1152: 1073: 556: 1983: 1918: 1754: 1673: 1444: 1338: 1201: 1167: 1105: 871: 339: 308: 304: 268: 158: 2011: 1650: 598: 1957: 1931: 1563: 1362: 1275: 902: 228: 763: 616: 541: 863: 834: 792: 720: 685: 656: 1608: 1603: 1598: 1419: 1054: 906: 800:
Malhotra OP, Philip G (1966). "Specificity of goat intestinal esterase".
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Barker DL, Jencks WP (1969). "Pig liver esterase. Physical properties".
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18:2, n-6), has a role as a human carboxylesterase inhibitor.
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Humans genes that encode carboxylesterase enzymes include:
1709: 730:"The purification and properties of horse liver esterase" 250: 2000: 369:
of evolutionarily related proteins (those with clear
249: 1896: 1860: 1829: 1798: 1747: 1666: 1554: 1506: 1492: 1470: 1452: 1438: 1418: 1357: 1261: 1100: 1068: 918: 197: 185: 173: 168: 148: 129: 117: 105: 93: 81: 69: 57: 52: 40: 28: 23: 18: 255: 1197:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase 278:belonging to the superfamily of proteins with 1725: 887: 8: 282:. Some exceptions include an esterase with 1732: 1718: 1710: 1503: 1449: 1435: 894: 880: 872: 165: 753: 710: 606: 248: 346:), formed by the synthesis from dietary 2007: 1087:Ubiquitin carboxy-terminal hydrolase L1 512: 307:such as toxins or drugs; the resulting 15: 1667:either deoxy- or ribo-     456:The last enzyme also participates in 7: 1248:Protein serine/threonine phosphatase 1349:Cyclic nucleotide phosphodiesterase 1343:Clostridium perfringens alpha toxin 1144:Tartrate-resistant acid phosphatase 256:{\displaystyle \rightleftharpoons } 1192:Pyruvate dehydrogenase phosphatase 712:10.1111/j.1432-1033.1969.tb00748.x 14: 1092:4-hydroxybenzoyl-CoA thioesterase 274:Most enzymes from this group are 231:reactions of the following form: 2010: 1410:N-acetylglucosamine-6-sulfatase 1298:Sphingomyelin phosphodiesterase 1219:Inositol-phosphate phosphatase 1082:Palmitoyl protein thioesterase 223:, EC 3.1.1.1; systematic name 1: 1582:RNA-induced silencing complex 1686:Serratia marcescens nuclease 1253:Dual-specificity phosphatase 1243:Protein tyrosine phosphatase 827:10.1016/0003-9861(84)90311-4 693:Bertram J, Krisch K (1969). 649:10.1016/0005-2744(69)90112-0 1163:Fructose 1,6-bisphosphatase 2049: 225:carboxylic-ester hydrolase 221:carboxylic-ester hydrolase 1888:Michaelis–Menten kinetics 1400:Galactosamine-6 sulfatase 956:6-phosphogluconolactonase 599:10.1007/s00335-010-9284-4 164: 1780:Diffusion-limited enzyme 1148:Purple acid phosphatases 561:pubchem.ncbi.nlm.nih.gov 431:methylbutyrate esterase, 446:vitamin A esterase, and 367:carboxylesterase family 1573:Microprocessor complex 1212:Beta-propeller phytase 815:Arch. Biochem. Biophys 637:Biochim. Biophys. Acta 257: 1873:Eadie–Hofstee diagram 1806:Allosteric regulation 1508:Endodeoxyribonuclease 1405:Iduronate-2-sulfatase 1158:Glucose 6-phosphatase 944:Butyrylcholinesterase 375:acetylcholinesterases 258: 1883:Lineweaver–Burk plot 1691:Micrococcal nuclease 1526:Deoxyribonuclease IV 1521:Deoxyribonuclease II 1454:Exodeoxyribonuclease 1114:Alkaline phosphatase 939:Acetylcholinesterase 388:acetylcholinesterase 247: 1546:UvrABC endonuclease 1516:Deoxyribonuclease I 1239:Protein phosphatase 1175:Protein phosphatase 973:Bile salt-dependent 961:PAF acetylhydrolase 856:10.1021/bi00833a035 785:10.1021/bi00833a033 678:10.1021/bi00838a001 443:triacetin esterase, 440:propionyl esterase, 1842:Enzyme superfamily 1775:Enzyme promiscuity 1679:Mung bean nuclease 1538:Restriction enzyme 1531:Restriction enzyme 557:"Arachidonic acid" 437:procaine esterase, 415:carboxylesterase 3 410:carboxylesterase 2 405:carboxylesterase 1 398:butyrate esterase, 301:phase I metabolism 280:α/β hydrolase fold 253: 1998: 1997: 1707: 1706: 1703: 1702: 1699: 1698: 1488: 1487: 1480:Oligonucleotidase 1425:deoxyribonuclease 1393:Steroid sulfatase 1268:Phosphodiesterase 997:Hormone-sensitive 746:10.1042/bj0580415 534:10.1021/bi500934j 528:(36): 5820–5829. 401:butyryl esterase, 371:sequence homology 286:-like structure ( 276:serine hydrolases 213: 212: 209: 208: 112:metabolic pathway 2040: 2015: 2014: 2006: 1878:Hanes–Woolf plot 1821:Enzyme activator 1816:Enzyme inhibitor 1790:Enzyme catalysis 1734: 1727: 1720: 1711: 1556:Endoribonuclease 1542: 1536: 1504: 1450: 1436: 1136:Acid phosphatase 1017:Monoacylglycerol 927:ester hydrolases 896: 889: 882: 873: 867: 838: 809: 796: 767: 757: 728:BURCH J (1954). 724: 714: 689: 660: 621: 620: 610: 593:(9–10): 427–41. 577: 571: 570: 568: 567: 552: 546: 545: 517: 450:cocaine esterase 317:arachidonic acid 295: 262: 260: 259: 254: 237:carboxylic ester 217:carboxylesterase 166: 19:carboxylesterase 16: 2048: 2047: 2043: 2042: 2041: 2039: 2038: 2037: 2023: 2022: 2021: 2009: 2001: 1999: 1994: 1906:Oxidoreductases 1892: 1868:Enzyme kinetics 1856: 1852:List of enzymes 1825: 1794: 1765:Catalytic triad 1743: 1738: 1708: 1695: 1662: 1550: 1540: 1534: 1497: 1484: 1472:Exoribonuclease 1466: 1443: 1427: 1423: 1414: 1388:Arylsulfatase L 1383:Arylsulfatase B 1378:Arylsulfatase A 1353: 1266: 1257: 1096: 1064: 926: 914: 900: 870: 841: 812: 799: 770: 727: 699:Eur. J. Biochem 692: 672:(10): 3879–89. 663: 634: 630: 628:Further reading 625: 624: 579: 578: 574: 565: 563: 554: 553: 549: 519: 518: 514: 509: 466: 454: 428:methylbutyrase, 383: 361: 357: 353: 337: 331: 325: 287: 245: 244: 242: 12: 11: 5: 2046: 2044: 2036: 2035: 2025: 2024: 2020: 2019: 1996: 1995: 1993: 1992: 1979: 1966: 1953: 1940: 1927: 1914: 1900: 1898: 1894: 1893: 1891: 1890: 1885: 1880: 1875: 1870: 1864: 1862: 1858: 1857: 1855: 1854: 1849: 1844: 1839: 1833: 1831: 1830:Classification 1827: 1826: 1824: 1823: 1818: 1813: 1808: 1802: 1800: 1796: 1795: 1793: 1792: 1787: 1782: 1777: 1772: 1767: 1762: 1757: 1751: 1749: 1745: 1744: 1739: 1737: 1736: 1729: 1722: 1714: 1705: 1704: 1701: 1700: 1697: 1696: 1694: 1693: 1688: 1683: 1682: 1681: 1670: 1668: 1664: 1663: 1661: 1660: 1655: 1654: 1653: 1648: 1643: 1638: 1628: 1623: 1618: 1613: 1612: 1611: 1606: 1601: 1596: 1586: 1585: 1584: 1575: 1560: 1558: 1552: 1551: 1549: 1548: 1543: 1528: 1523: 1518: 1512: 1510: 1501: 1490: 1489: 1486: 1485: 1483: 1482: 1476: 1474: 1468: 1467: 1465: 1464: 1458: 1456: 1447: 1433: 1416: 1415: 1413: 1412: 1407: 1402: 1397: 1396: 1395: 1390: 1385: 1380: 1367: 1365: 1355: 1354: 1352: 1351: 1346: 1336: 1331: 1322: 1317: 1312: 1307: 1306: 1305: 1295: 1294: 1293: 1288: 1278: 1272: 1270: 1259: 1258: 1256: 1255: 1250: 1245: 1236: 1235: 1234: 1216: 1215: 1214: 1204: 1199: 1194: 1189: 1184: 1183: 1182: 1172: 1171: 1170: 1160: 1155: 1150: 1133: 1132: 1131: 1126: 1121: 1110: 1108: 1098: 1097: 1095: 1094: 1089: 1084: 1078: 1076: 1066: 1065: 1063: 1062: 1057: 1051: 1050: 1049: 1048: 1043: 1038: 1027: 1026: 1025: 1024: 1022:Diacylglycerol 1019: 1014: 1009: 1004: 999: 994: 989: 984: 975: 964: 963: 958: 953: 951:Pectinesterase 948: 947: 946: 941: 934:Cholinesterase 930: 928: 916: 915: 901: 899: 898: 891: 884: 876: 869: 868: 839: 810: 797: 768: 725: 690: 661: 631: 629: 626: 623: 622: 572: 547: 511: 510: 508: 505: 501: 500: 495: 490: 485: 480: 475: 465: 462: 460:biosynthesis. 453: 452: 447: 444: 441: 438: 435: 432: 429: 426: 423: 420: 417: 412: 407: 402: 399: 396: 393: 390: 384: 382: 379: 359: 355: 351: 335: 329: 323: 272: 271: 252: 240: 211: 210: 207: 206: 201: 195: 194: 189: 183: 182: 177: 171: 170: 162: 161: 152: 146: 145: 134: 127: 126: 121: 115: 114: 109: 103: 102: 97: 91: 90: 85: 79: 78: 73: 67: 66: 61: 55: 54: 50: 49: 44: 38: 37: 32: 26: 25: 21: 20: 13: 10: 9: 6: 4: 3: 2: 2045: 2034: 2031: 2030: 2028: 2018: 2013: 2008: 2004: 1990: 1986: 1985: 1980: 1977: 1973: 1972: 1967: 1964: 1960: 1959: 1954: 1951: 1947: 1946: 1941: 1938: 1934: 1933: 1928: 1925: 1921: 1920: 1915: 1912: 1908: 1907: 1902: 1901: 1899: 1895: 1889: 1886: 1884: 1881: 1879: 1876: 1874: 1871: 1869: 1866: 1865: 1863: 1859: 1853: 1850: 1848: 1847:Enzyme family 1845: 1843: 1840: 1838: 1835: 1834: 1832: 1828: 1822: 1819: 1817: 1814: 1812: 1811:Cooperativity 1809: 1807: 1804: 1803: 1801: 1797: 1791: 1788: 1786: 1783: 1781: 1778: 1776: 1773: 1771: 1770:Oxyanion hole 1768: 1766: 1763: 1761: 1758: 1756: 1753: 1752: 1750: 1746: 1742: 1735: 1730: 1728: 1723: 1721: 1716: 1715: 1712: 1692: 1689: 1687: 1684: 1680: 1677: 1676: 1675: 1672: 1671: 1669: 1665: 1659: 1656: 1652: 1649: 1647: 1644: 1642: 1639: 1637: 1634: 1633: 1632: 1629: 1627: 1624: 1622: 1619: 1617: 1614: 1610: 1607: 1605: 1602: 1600: 1597: 1595: 1592: 1591: 1590: 1587: 1583: 1579: 1576: 1574: 1570: 1567: 1566: 1565: 1562: 1561: 1559: 1557: 1553: 1547: 1544: 1539: 1532: 1529: 1527: 1524: 1522: 1519: 1517: 1514: 1513: 1511: 1509: 1505: 1502: 1500: 1495: 1491: 1481: 1478: 1477: 1475: 1473: 1469: 1463: 1460: 1459: 1457: 1455: 1451: 1448: 1446: 1441: 1437: 1434: 1431: 1426: 1421: 1417: 1411: 1408: 1406: 1403: 1401: 1398: 1394: 1391: 1389: 1386: 1384: 1381: 1379: 1376: 1375: 1374: 1373: 1372:arylsulfatase 1369: 1368: 1366: 1364: 1360: 1356: 1350: 1347: 1344: 1340: 1337: 1335: 1332: 1330: 1326: 1323: 1321: 1318: 1316: 1313: 1311: 1308: 1304: 1301: 1300: 1299: 1296: 1292: 1289: 1287: 1284: 1283: 1282: 1281:Phospholipase 1279: 1277: 1274: 1273: 1271: 1269: 1264: 1260: 1254: 1251: 1249: 1246: 1244: 1240: 1237: 1233: 1229: 1225: 1222: 1221: 1220: 1217: 1213: 1210: 1209: 1208: 1205: 1203: 1200: 1198: 1195: 1193: 1190: 1188: 1185: 1181: 1178: 1177: 1176: 1173: 1169: 1166: 1165: 1164: 1161: 1159: 1156: 1154: 1151: 1149: 1145: 1141: 1137: 1134: 1130: 1127: 1125: 1122: 1120: 1117: 1116: 1115: 1112: 1111: 1109: 1107: 1103: 1099: 1093: 1090: 1088: 1085: 1083: 1080: 1079: 1077: 1075: 1071: 1067: 1061: 1058: 1056: 1053: 1052: 1047: 1044: 1042: 1039: 1037: 1034: 1033: 1032: 1031:Phospholipase 1029: 1028: 1023: 1020: 1018: 1015: 1013: 1010: 1008: 1005: 1003: 1000: 998: 995: 993: 990: 988: 985: 983: 979: 976: 974: 971: 970: 969: 966: 965: 962: 959: 957: 954: 952: 949: 945: 942: 940: 937: 936: 935: 932: 931: 929: 925: 921: 917: 912: 908: 904: 897: 892: 890: 885: 883: 878: 877: 874: 865: 861: 857: 853: 850:(5): 2013–8. 849: 845: 840: 836: 832: 828: 824: 821:(2): 612–21. 820: 816: 811: 807: 803: 798: 794: 790: 786: 782: 779:(5): 2000–6. 778: 774: 769: 765: 761: 756: 751: 747: 743: 740:(3): 415–26. 739: 735: 731: 726: 722: 718: 713: 708: 704: 700: 696: 691: 687: 683: 679: 675: 671: 667: 662: 658: 654: 650: 646: 643:(1): 128–37. 642: 638: 633: 632: 627: 618: 614: 609: 604: 600: 596: 592: 588: 584: 576: 573: 562: 558: 551: 548: 543: 539: 535: 531: 527: 523: 516: 513: 506: 504: 499: 496: 494: 491: 489: 486: 484: 481: 479: 476: 474: 471: 470: 469: 463: 461: 459: 451: 448: 445: 442: 439: 436: 434:monobutyrase, 433: 430: 427: 424: 421: 418: 416: 413: 411: 408: 406: 403: 400: 397: 394: 392:ali-esterase, 391: 389: 386: 385: 380: 378: 376: 372: 368: 363: 349: 348:linoleic acid 345: 341: 334: 328: 322: 318: 314: 310: 306: 302: 297: 294: 290: 285: 281: 277: 270: 266: 238: 234: 233: 232: 230: 226: 222: 218: 205: 202: 200: 196: 193: 190: 188: 184: 181: 178: 176: 172: 167: 163: 160: 156: 153: 151: 150:Gene Ontology 147: 144: 141: 138: 135: 132: 128: 125: 122: 120: 116: 113: 110: 108: 104: 101: 98: 96: 92: 89: 88:NiceZyme view 86: 84: 80: 77: 74: 72: 68: 65: 62: 60: 56: 51: 48: 45: 43: 39: 36: 33: 31: 27: 22: 17: 1984:Translocases 1981: 1968: 1955: 1942: 1929: 1919:Transferases 1916: 1903: 1760:Binding site 1541:}} 1535:{{ 1499:Endonuclease 1430:ribonuclease 1370: 1153:Nucleotidase 1074:Thioesterase 847: 844:Biochemistry 843: 818: 814: 805: 801: 776: 773:Biochemistry 772: 737: 733: 705:(1): 122–6. 702: 698: 669: 666:Biochemistry 665: 640: 636: 590: 587:Mamm. Genome 586: 575: 564:. Retrieved 560: 550: 525: 522:Biochemistry 521: 515: 502: 467: 455: 364: 309:carboxylates 298: 273: 224: 220: 216: 214: 76:BRENDA entry 1755:Active site 1674:Nuclease S1 1445:Exonuclease 1339:Lecithinase 1168:Calcineurin 1106:Phosphatase 1012:Lipoprotein 1002:Endothelial 425:esterase D, 422:esterase B, 419:esterase A, 395:B-esterase, 305:xenobiotics 284:β-lactamase 269:carboxylate 215:The enzyme 64:IntEnz view 24:Identifiers 1958:Isomerases 1932:Hydrolases 1799:Regulation 987:Pancreatic 924:Carboxylic 808:: 386–402. 802:Biochem. Z 734:Biochem. J 566:2022-11-24 507:References 313:conjugated 296:​). 133:structures 100:KEGG entry 47:9016-18-6 1837:EC number 1564:RNase III 1422:(includes 1363:Sulfatase 1276:Autotaxin 1140:Prostatic 992:Lysosomal 907:esterases 903:Hydrolase 555:PubChem. 311:are then 251:⇌ 229:catalyzes 53:Databases 2033:EC 3.1.1 2027:Category 1861:Kinetics 1785:Cofactor 1748:Activity 1658:RNase T1 1420:Nuclease 1055:Cutinase 764:13208632 617:20931200 542:25101647 458:alkaloid 381:Examples 204:proteins 192:articles 180:articles 137:RCSB PDB 2017:Biology 1971:Ligases 1741:Enzymes 1631:RNase E 1626:RNase Z 1621:RNase A 1616:RNase P 1589:RNase H 1207:Phytase 1007:Hepatic 982:Lingual 978:Gastric 864:5785222 835:6208846 793:5785220 755:1269916 721:5353595 686:4981346 657:4884138 608:3127206 265:alcohol 159:QuickGO 124:profile 107:MetaCyc 42:CAS no. 35:3.1.1.1 2003:Portal 1945:Lyases 1569:Drosha 1494:3.1.21 1462:RecBCD 1440:3.1.11 1060:PETase 968:Lipase 862:  833:  791:  762:  752:  719:  684:  655:  615:  605:  540:  350:(LA: C 187:PubMed 169:Search 155:AmiGO 143:PDBsum 83:ExPASy 71:BRENDA 59:IntEnz 30:EC no. 1897:Types 1578:Dicer 1533:;see 1359:3.1.6 1329:PDE4B 1325:PDE4A 1263:3.1.4 1232:IMPA3 1228:IMPA2 1224:IMPA1 1102:3.1.3 1070:3.1.2 920:3.1.1 464:Genes 338:; 20: 119:PRIAM 1989:list 1982:EC7 1976:list 1969:EC6 1963:list 1956:EC5 1950:list 1943:EC4 1937:list 1930:EC3 1924:list 1917:EC2 1911:list 1904:EC1 1496:-31: 1442:-16: 1428:and 1334:PDE5 1320:PDE3 1315:PDE2 1310:PDE1 1202:PTEN 1187:OCRL 1180:PP2A 1129:ALPP 1124:ALPL 1119:ALPI 913:3.1) 860:PMID 831:PMID 789:PMID 760:PMID 717:PMID 682:PMID 653:PMID 613:PMID 538:PMID 498:CES8 493:CES7 488:CES4 483:CES3 478:CES2 473:CES1 365:The 319:(AA 293:1ci8 267:+ a 219:(or 199:NCBI 140:PDBe 95:KEGG 1651:4/5 852:doi 823:doi 819:234 806:346 781:doi 750:PMC 742:doi 707:doi 674:doi 645:doi 641:171 603:PMC 595:doi 530:doi 344:n-6 303:of 289:PDB 263:an 239:+ H 175:PMC 131:PDB 2029:: 1609:2C 1604:2B 1599:2A 1580:: 1571:: 1361:: 1241:: 1230:, 1226:, 1142:)/ 1104:: 1072:: 1041:A2 1036:A1 922:: 911:EC 905:: 858:. 846:. 829:. 817:. 804:. 787:. 775:. 758:. 748:. 738:58 736:. 732:. 715:. 703:11 701:. 697:. 680:. 668:. 651:. 639:. 611:. 601:. 591:21 589:. 585:. 559:. 536:. 526:53 524:. 377:. 356:32 352:18 342:, 330:32 324:20 291:: 243:O 235:a 227:) 157:/ 2005:: 1991:) 1987:( 1978:) 1974:( 1965:) 1961:( 1952:) 1948:( 1939:) 1935:( 1926:) 1922:( 1913:) 1909:( 1733:e 1726:t 1719:v 1646:3 1641:2 1636:1 1594:1 1432:) 1345:) 1341:( 1327:/ 1303:1 1291:D 1286:C 1265:: 1146:/ 1138:( 1046:B 980:/ 909:( 895:e 888:t 881:v 866:. 854:: 848:8 837:. 825:: 795:. 783:: 777:8 766:. 744:: 723:. 709:: 688:. 676:: 670:8 659:. 647:: 619:. 597:: 569:. 544:. 532:: 360:2 358:O 354:H 340:4 336:2 333:O 327:H 321:C 241:2

Index

EC no.
3.1.1.1
CAS no.
9016-18-6
IntEnz
IntEnz view
BRENDA
BRENDA entry
ExPASy
NiceZyme view
KEGG
KEGG entry
MetaCyc
metabolic pathway
PRIAM
profile
PDB
RCSB PDB
PDBe
PDBsum
Gene Ontology
AmiGO
QuickGO
PMC
articles
PubMed
articles
NCBI
proteins
catalyzes

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