39:
152:. Biologic drugs, i.e. anti-TNFα or anti-CD20 monoclonal antibodies, have been recently introduced as alternative treatments in refractory cases. There are some concerns with the use of anti-TNF agents in patients with systemic autoimmune diseases due to the risk of triggering disease exacerbations.
598:
221:
causes a reduction in the peak sodium current leading to the typical ECG features of
Brugada syndrome, but which simultaneously increases the sustained late sodium current leading to the ECG features of
641:
52:
is a medical condition which shares features of at least two more widely recognised disorders. Examples of overlap syndromes can be found in many medical specialties such as overlapping
634:
627:
127:
331:
Iaccarino L, Gatto M, Bettio S, Caso F, Rampudda M, Zen M, Ghirardello A, Punzi L, Doria A (January 2013). "Overlap connective tissue disease syndromes".
857:
183:
In gastroenterology, the term overlap syndrome may be used to describe autoimmune liver diseases that combine characteristic features of
138:
837:
570:
674:
168:
774:
268:
77:
163:
that shares features with two or more distinct vasculitis syndromes. The most common type of polyangiitis overlap syndrome is
750:
192:
679:
880:
666:
95:
366:
Leavitt RY, Fauci AS (July 1986). "Polyangiitis overlap syndrome. Classification and prospective clinical experience".
842:
651:
188:
53:
485:"Desmosomes and the sodium channel complex: implications for arrhythmogenic cardiomyopathy and Brugada syndrome"
716:
164:
122:
725:
832:
827:
133:
822:
885:
694:
817:
745:
184:
116:
38:
801:
707:
243:
172:
890:
793:
313:
149:
101:
549:
514:
465:
444:"Clinical Spectrum of SCN5A Mutations: Long QT Syndrome, Brugada Syndrome, and Cardiomyopathy"
424:
383:
348:
305:
27:
789:
541:
504:
496:
455:
414:
375:
340:
297:
223:
204:
61:
532:
Postma, Dirkje S.; Rabe, Klaus F. (24 September 2015). "The Asthma–COPD Overlap
Syndrome".
852:
712:
684:
111:
91:
In overlap syndrome, features of the following diseases are found (most common listed):
755:
619:
509:
484:
227:
218:
145:
144:
The treatment of overlapping connective tissue disorders is mainly based on the use of
81:
288:
Maddison PJ (December 1991). "Overlap syndromes and mixed connective tissue disease".
874:
379:
301:
317:
721:
106:
57:
32:
84:. Diagnosis depends on which diseases the patient shows symptoms and has positive
419:
402:
344:
737:
460:
443:
231:
607:
500:
263:
160:
85:
65:
847:
553:
518:
469:
428:
352:
545:
387:
309:
207:
can share features with related disorders caused by mutations in the same
702:
590:
175:. Sometimes polyangiitis overlap syndrome is used as a synonym for MPA.
571:
The
Myositis Association Overlap Syndrome 2011 Conference Presentation
602:
247:
403:"Overlap syndromes of autoimmune hepatitis: diagnosis and treatment"
213:
251:
208:
623:
246:
is a condition in which clinical features and symptoms of both
211:. An overlap syndrome can be seen whereby a mutation in the
76:
Examples of overlap syndromes in rheumatology include
401:
Aguilar-Nájera O, Velasco-Zamora JA, Torre A (2015).
580:
810:
787:
736:
693:
665:
658:
584:
254:are present in a person and overlap significantly.
26:
21:
635:
128:Eosinophilic granulomatosis with polyangiitis
8:
662:
642:
628:
620:
581:
203:In cardiology, genetic conditions such as
37:
18:
508:
459:
418:
226:. Brugada syndrome can also overlap with
167:(MPA), which shares features with EGPA,
280:
858:Congenital contractural arachnodactyly
407:Revista de Gastroenterologia de Mexico
7:
244:asthma-COPD Overlap Syndrome (ACOS)
139:Antiphospholipid antibody syndrome
14:
489:Trends in Cardiovascular Medicine
483:Cerrone M, Delmar M (July 2014).
448:JACC: Clinical Electrophysiology
368:The American Journal of Medicine
302:10.1097/00002281-199112000-00016
230:due to certain mutations in the
169:granulomatosis with polyangiitis
775:Mixed connective tissue disease
534:New England Journal of Medicine
290:Current Opinion in Rheumatology
269:Mixed connective tissue disease
78:mixed connective tissue disease
751:Progressive systemic sclerosis
442:Wilde AA, Amin AS (May 2018).
193:primary sclerosing cholangitis
1:
838:Eosinophilia–myalgia syndrome
228:arrhythmogenic cardiomyopathy
157:polyangiitis overlap syndrome
667:Systemic lupus erythematosus
420:10.1016/j.rgmxen.2015.07.001
380:10.1016/0002-9343(86)90186-5
345:10.1016/j.autrev.2012.06.004
96:Systemic lupus erythematosus
652:connective tissue disorders
461:10.1016/j.jacep.2018.03.006
88:for in their lab serology.
54:connective tissue disorders
907:
217:gene encoding the cardiac
766:
680:Libman–Sacks endocarditis
501:10.1016/j.tcm.2014.02.001
189:primary biliary cirrhosis
717:Juvenile dermatomyositis
165:microscopic polyangiitis
726:Inclusion body myositis
224:Long QT syndrome type 3
843:Ehlers–Danlos syndrome
833:Eosinophilic fasciitis
828:Polymyalgia rheumatica
134:Autoimmune thyroiditis
695:Inflammatory myopathy
546:10.1056/NEJMra1411863
159:refers to a systemic
818:IgG4-related disease
746:Systemic scleroderma
333:Autoimmunity Reviews
185:autoimmune hepatitis
117:Rheumatoid arthritis
881:Autoimmune diseases
708:Dermatopolymyositis
173:panarteritis nodosa
150:immunosuppressants
123:Sjögren's syndrome
102:Systemic sclerosis
60:, and overlapping
868:
867:
783:
782:
617:
616:
540:(13): 1241–1249.
62:genetic disorders
46:
45:
16:Medical condition
898:
823:Behçet's disease
802:Sjögren syndrome
790:hypersensitivity
771:Overlap syndrome
675:Drug-induced SLE
663:
644:
637:
630:
621:
582:
558:
557:
529:
523:
522:
512:
480:
474:
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463:
439:
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432:
422:
398:
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363:
357:
356:
328:
322:
321:
285:
242:In pulmonology,
205:Brugada syndrome
179:Gastroenterology
50:overlap syndrome
42:
41:
22:Overlap syndrome
19:
906:
905:
901:
900:
899:
897:
896:
895:
871:
870:
869:
864:
853:Marfan syndrome
806:
779:
762:
732:
713:Dermatomyositis
689:
685:Lupus nephritis
654:
648:
618:
613:
612:
593:
579:
567:
565:Further reading
562:
561:
531:
530:
526:
482:
481:
477:
441:
440:
436:
400:
399:
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365:
364:
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330:
329:
325:
296:(6): 995–1000.
287:
286:
282:
277:
260:
240:
201:
181:
146:corticosteroids
112:Dermatomyositis
74:
36:
17:
12:
11:
5:
904:
902:
894:
893:
888:
883:
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872:
866:
865:
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861:
860:
855:
845:
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835:
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804:
798:
796:
785:
784:
781:
780:
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777:
767:
764:
763:
761:
760:
759:
758:
756:CREST syndrome
753:
742:
740:
734:
733:
731:
730:
729:
728:
719:
705:
699:
697:
691:
690:
688:
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682:
677:
671:
669:
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655:
649:
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632:
624:
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611:
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594:
589:
588:
586:
585:Classification
578:
577:External links
575:
574:
573:
566:
563:
560:
559:
524:
475:
454:(5): 569–579.
434:
393:
358:
323:
279:
278:
276:
273:
272:
271:
266:
259:
256:
239:
236:
219:sodium channel
200:
197:
180:
177:
142:
141:
136:
131:
125:
120:
114:
109:
104:
99:
82:scleromyositis
73:
70:
44:
43:
30:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
903:
892:
889:
887:
884:
882:
879:
878:
876:
859:
856:
854:
851:
850:
849:
846:
844:
841:
839:
836:
834:
831:
829:
826:
824:
821:
819:
816:
815:
813:
809:
803:
800:
799:
797:
795:
791:
786:
776:
772:
769:
768:
765:
757:
754:
752:
749:
748:
747:
744:
743:
741:
739:
735:
727:
723:
720:
718:
714:
711:
710:
709:
706:
704:
701:
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698:
696:
692:
686:
683:
681:
678:
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668:
664:
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657:
653:
645:
640:
638:
633:
631:
626:
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622:
609:
605:
604:
600:
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595:
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587:
583:
576:
572:
569:
568:
564:
555:
551:
547:
543:
539:
535:
528:
525:
520:
516:
511:
506:
502:
498:
495:(5): 184–90.
494:
490:
486:
479:
476:
471:
467:
462:
457:
453:
449:
445:
438:
435:
430:
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408:
404:
397:
394:
389:
385:
381:
377:
373:
369:
362:
359:
354:
350:
346:
342:
339:(3): 363–73.
338:
334:
327:
324:
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311:
307:
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299:
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291:
284:
281:
274:
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79:
71:
69:
67:
63:
59:
55:
51:
40:
34:
31:
29:
25:
20:
886:Rheumatology
770:
722:Polymyositis
597:
537:
533:
527:
492:
488:
478:
451:
447:
437:
413:(2): 150–9.
410:
406:
396:
374:(1): 79–85.
371:
367:
361:
336:
332:
326:
293:
289:
283:
241:
212:
202:
182:
156:
154:
143:
107:Polymyositis
90:
75:
72:Rheumatology
58:rheumatology
49:
47:
33:Rheumatology
738:Scleroderma
238:Pulmonology
232:plakophilin
875:Categories
794:autoimmune
275:References
264:Autoimmune
199:Cardiology
161:vasculitis
86:antibodies
66:cardiology
891:Syndromes
848:fibrillin
650:Systemic
155:The term
28:Specialty
703:Myositis
554:26398072
519:24656989
470:29798782
429:26091564
353:22743033
318:43146562
258:See also
659:General
510:4099253
388:2873744
310:1772755
788:Other
552:
517:
507:
468:
427:
386:
351:
316:
308:
248:asthma
234:gene.
130:(EGPA)
35:
811:Other
608:M35.1
314:S2CID
214:SCN5A
98:(SLE)
550:PMID
515:PMID
466:PMID
425:PMID
384:PMID
349:PMID
306:PMID
252:COPD
250:and
209:gene
191:and
171:and
148:and
119:(RA)
80:and
599:ICD
542:doi
538:373
505:PMC
497:doi
456:doi
415:doi
376:doi
341:doi
298:doi
64:in
56:in
48:An
877::
773:/
724:*
606::
603:10
548:.
536:.
513:.
503:.
493:24
491:.
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446:.
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411:80
409:.
405:.
382:.
372:81
370:.
347:.
337:12
335:.
312:.
304:.
292:.
195:.
187:,
68:.
792:/
715:/
643:e
636:t
629:v
601:-
591:D
556:.
544::
521:.
499::
472:.
458::
452:4
431:.
417::
390:.
378::
355:.
343::
320:.
300::
294:3
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