115:
domains. OBPs are divergent across and within species. The percentage of conserved residues between species has been shown to be as low as 8%. OBPs' have a characteristic signature that is recognized by a conserved pattern of six cysteines that are connected in the protein by three disulfide bridges.
124:
The functions of odorant binding proteins as a whole is not well understood. They are generally believed to increase the solubility of hydrophobic odorants by binding them and transporting them across the aqueous sensillum lymph to receptors in the dendrites, and several studies support a role for
148:
does not reduce the magnitude of their olfactory responses, suggesting that Obp28a is not required for odorant transport and that ab8 sensilla do not require an abundant OBP. Their results further suggest Obp28a may be buffering changes in the odor environment, possibly as molecular gain control,
227:
OBP gene family has been classified into several subfamilies based on structural features, functional information, and phylogenetic relationships: the
Classic, Minus-C, Plus-C, Dimer, PBP/GOBP, ABPI and ABPII, CRLBP, and D7 subfamilies. These subfamilies are unequally distributed across
668:
da Costa, Kauȇ Santana; Galúcio, João Marcos; da Costa, Clauber
Henrique Souza; Santana, Amanda Ruslana; dos Santos Carvalho, Vitor; do Nascimento, Lidiane Diniz; Lima e Lima, Anderson Henrique; Neves Cruz, Jorddy; Alves, Claudio Nahum; Lameira, Jerônimo (2019-12-31).
129:. Some odorant binding proteins are hypothesized to hasten odor response termination by extracting odorant molecules from the sensillar lymph or from receptors themselves. Presently, just one OBP, Obp76a, has been thoroughly investigated in the olfactory system of
2412:
Park, S.-K.; Shanbhag, S. R.; Wang, Q.; Hasan, G.; Steinbrecht, R. A.; Pikielny, C. W. (2000-03-30). "Expression patterns of two putative odorant-binding proteins in the olfactory organs of
Drosophila melanogaster have different implications for their functions".
726:
Thireou, Trias; Kythreoti, Georgia; Tsitsanou, Katerina E.; Koussis, Konstantinos; Drakou, Christina E.; Kinnersley, Julie; Kröber, Thomas; Guerin, Patrick M.; Zhou, Jing-Jiang; Iatrou, Kostas; Eliopoulos, Elias (July 2018).
1692:
Bucci, Brigid K.; Kruse, Schoen W.; Thode, Anna B.; Alvarado, Sylvia M.; Jones, David N. M. (February 2006). "Effect ofn-Alcohols on the
Structure and Stability of theDrosophilaOdorant Binding Protein LUSH†".
2360:
S., Shanbhag; S.-K., Park; C., Pikielny; R., Steinbrecht (2001-05-28). "Gustatory organs of
Drosophila melanogaster : fine structure and expression of the putative odorant-binding protein PBPRP2".
671:"Exploring the Potentiality of Natural Products from Essential Oils as Inhibitors of Odorant-Binding Proteins: A Structure- and Ligand-Based Virtual Screening Approach To Find Novel Mosquito Repellents"
77:. The aqueous solubility of hydrophobic odorants is greatly enhanced via odorant-binding proteins, which exist in the extracellular fluid surrounding the odorant receptors. This family is composed of
168:
of the antennae. Within and between species, OBPs are expressed in several different tissues, including the antennal sensilla, the taste system, and chemosensory organs. They are also known to be
2527:
Forêt, Sylvain; Wanner, Kevin W.; Maleszka, Ryszard (January 2007). "Chemosensory proteins in the honey bee: Insights from the annotated genome, comparative analyses and expressional profiling".
2128:
Pikielny, C.W.; Hasan, G.; Rouyer, F.; Rosbash, M. (January 1994). "Members of a family of drosophila putative odorant-binding proteins are expressed in different subsets of olfactory hairs".
1060:
Biessmann, Harald; Andronopoulou, Evi; Biessmann, Max R.; Douris, Vassilis; Dimitratos, Spiros D.; Eliopoulos, Elias; Guerin, Patrick M.; Iatrou, Kostas; Justice, Robin W. (2010-03-01).
116:
Their structures have been investigated to explore new bio-inspired repellents against mosquitoes, with potentially improved OBP binding affinity, selectivity, and reduced volatility.
133:
and has a known physiological role. Obp76a, better known as LUSH, is located trichoid sensilla and is necessary for normal response of the odor receptor Or67d to its pheromone ligand
92:
OBPs are small proteins on the order of 14 kDa in size. All odorant binding proteins are believed to have a common structure despite their genetic diversity and highly variable
283:
Vogt, R. G.; Prestwich, G. D.; Lerner, M. R. (January 1991). "Odorant-binding-protein subfamilies associate with distinct classes of olfactory receptor neurons in insects".
2181:"The Co-Expression Pattern of Odorant Binding Proteins and Olfactory Receptors Identify Distinct Trichoid Sensilla on the Antenna of the Malaria Mosquito Anopheles gambiae"
2456:
50:
bonds. Although the function of the OBPs as a whole is not well established, it is believed that they act as odorant transporters, delivering the odorant molecules to
1013:"Comparative Genomics of the Odorant-Binding and Chemosensory Protein Gene Families across the Arthropoda: Origin and Evolutionary History of the Chemosensory System"
383:
Shi, W.; Ostrov, D.A.; Gerchman, S.E.; Graziano, V.; Kycia, H.; Studier, B.; Almo, S.C.; Burley, S.K. (1999-08-25). "PNP Oxidase from
Saccharomyces Cerevisiae".
1403:
Benton, Richard; Vannice, Kirsten S.; Vosshall, Leslie B. (2007-10-17). "An essential role for a CD36-related receptor in pheromone detection in
Drosophila".
576:
Tegoni, Mariella; Campanacci, Valérie; Cambillau, Christian (May 2004). "Structural aspects of sexual attraction and chemical communication in insects".
164:, they are encoded by 52 genes of the same family yet only share 20% amino acid similarity between themselves. Some are encoded by the most abundant
2577:"Comparative genomic analysis of the odorant-binding protein family in 12 Drosophila genomes: purifying selection and birth-and-death evolution"
729:"Identification of novel bioinspired synthetic mosquito repellents by combined ligand-based screening and OBP-structure-based molecular docking"
524:
Lartigue, Audrey; Campanacci, Valérie; Roussel, Alain; Larsson, Anna M.; Jones, T. Alwyn; Tegoni, Mariella; Cambillau, Christian (2002-08-30).
2179:
Schultze, Anna; Pregitzer, Pablo; Walter, Marika F.; Woods, Daniel F.; Marinotti, Osvaldo; Breer, Heinz; Krieger, Jürgen (2013-07-05).
1738:"The Role of Multiple Hydrogen-Bonding Groups in Specific Alcohol Binding Sites in Proteins: Insights from Structural Studies of LUSH"
84:
These proteins were initially identified on the basis of their ability to bind with moderate-affinity radioactively labeled odorants.
2472:"Function and evolution of a gene family encoding odorant binding-like proteins in a social insect, the honey bee (Apis mellifera)"
1793:
Zhou, Jing-Jiang; Zhang, Guo-An; Huang, Wensheng; Birkett, Michael A; Field, Linda M; Pickett, John A; Pelosi, Paolo (2004-01-07).
245:
152:
OBPs are thought to have multiple roles besides olfaction, including reproduction, egg laying and antiinflammatory responses.
1062:"The Anopheles gambiae Odorant Binding Protein 1 (AgamOBP1) Mediates Indole Recognition in the Antennae of Female Mosquitoes"
1300:
Ziegelberger, Gunde (September 1995). "Redox-Shift of the
Pheromone-Binding Protein in the Silkmoth Antheraea Polyphemus".
425:"The odorant-binding proteins of Drosophila melanogaster : annotation and characterization of a divergent gene family"
137:(cVA), although responses of Or67d to cVA have been detected in the absence of Obp76a LUSH has also been found to bind cVA
81:(PBP), which are male-specific and associate with pheromone-sensitive neurons and general-odorant-binding proteins (GOBP).
1795:"Revisiting the odorant-binding protein LUSH ofDrosophila melanogaster: evidence for odour recognition and discrimination"
2303:
Jeong, Yong Taek; Shim, Jaewon; Oh, So Ra; Yoon, Hong In; Kim, Chul Hoon; Moon, Seok Jun; Montell, Craig (August 2013).
907:"Conformational Change in the Pheromone-binding Protein fromBombyx mori Induced by pH and by Interaction with Membranes"
1580:"Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster"
105:
2640:
1348:"Activation of Pheromone-Sensitive Neurons Is Mediated by Conformational Activation of Pheromone-Binding Protein"
260:
93:
78:
27:
1129:"Knockdown of a Mosquito Odorant-binding Protein Involved in the Sensitive Detection of Oviposition Attractants"
2248:"A large family of divergent Drosophila odorant-binding proteins expressed in gustatory and olfactory sensilla"
1241:
Vogt, Richard G.; Riddiford, Lynn M. (September 1981). "Pheromone binding and inactivation by moth antennae".
1127:
Pelletier, Julien; Guidolin, Aline; Syed, Zainulabeuddin; Cornel, Anthony J.; Leal, Walter S. (2010-02-27).
203:) has revealed that the OBP genes significantly differ between species. The OBP family contains 21 (in A.
111:. Insect OBPs share very little amino acid sequence similarity to vertebrate OBPs as they mainly contain
2450:
840:"Kinetic properties of a sex pheromone-degrading enzyme: the sensillar esterase of Antheraea polyphemus"
396:
2019:"An RNA-Seq Screen of the Drosophila Antenna Identifies a Transporter Necessary for Ammonia Detection"
2192:
1464:"Requirement for Drosophila SNMP1 for Rapid Activation and Termination of Pheromone-Induced Activity"
1412:
1250:
1073:
851:
477:"Sexual attraction in the silkworm moth: structure of the pheromone-binding-protein–bombykol complex"
144:
In 2016, Larter et al. found that the deletion of the sole abundant OBP, Obp28a, in ab8 sensilla of
2645:
781:"Ligands for Pheromone-Sensing Neurons Are Not Conformationally Activated Odorant Binding Proteins"
219:. Generally these genes are irregularly scattered across the genome. Most (69% of the OBP genes in
62:
2394:
2161:
2078:"Putative Drosophila pheromone-binding proteins expressed in a subregion of the olfactory system"
1444:
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Hekmat-Scafe, Daria S.; Scafe, Charles R.; McKinney, Aimee J.; Tanouye, Mark A. (2002-09-01).
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1962:"Genome-Wide Analysis of the Odorant-Binding Protein Gene Family in Drosophila melanogaster"
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Pelosi, Paolo; Iovinella, Immacolata; Zhu, Jiao; Wang, Guirong; Dani, Francesca R. (2018).
779:
Gomez-Diaz, Carolina; Reina, Jaime H.; Cambillau, Christian; Benton, Richard (2013-04-30).
409:
2305:"An Odorant-Binding Protein Required for Suppression of Sweet Taste by Bitter Chemicals"
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Sandler, Benjamin H; Nikonova, Larisa; Leal, Walter S; Clardy, Jon (February 2000).
141:
and is known to bind other insect pheromones, short-chain alcohols, and phthalates.
1448:
1286:
1186:"Functional dissection of Odorant binding protein genes in Drosophila melanogaster"
16:
Soluble proteins secreted by auxiliary cells surrounding olfactory receptor neurons
2263:
328:"Identification of a specific olfactory receptor for 2-isobutyl-3-methoxypyrazine"
2320:
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2035:
1480:
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797:
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Xu, PingXi; Atkinson, Rachel; Jones, David N.M.; Smith, Dean P. (January 2005).
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101:
74:
43:
2540:
1903:"Beyond chemoreception: diverse tasks of soluble olfactory proteins in insects"
1736:
Thode, Anna B.; Kruse, Schoen W.; Nix, Jay C.; Jones, David N.M. (March 2008).
1363:
1346:
Laughlin, John D.; Ha, Tal Soo; Jones, David N.M.; Smith, Dean P. (June 2008).
744:
589:
2593:
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McKenna, M. P.; Hekmat-Scafe, D. S.; Gaines, P.; Carlson, J. R. (1994-06-10).
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Katti, S.; Lokhande, N.; González, D.; Cassill, A.; Renthal, R. (2012-11-01).
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959:"Drosophila OBP LUSH Is Required for Activity of Pheromone-Sensitive Neurons"
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2017:
Menuz, Karen; Larter, Nikki K.; Park, Joori; Carlson, John R. (2014-11-20).
864:
637:
621:"Diversity of Odorant-binding Proteins and Chemosensory Proteins in Insects"
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Kruse, Schoen W; Zhao, Rui; Smith, Dean P; Jones, David N M (2003-07-27).
1329:
891:
388:
369:
312:
296:
1028:
526:"X-ray Structure and Ligand Binding Study of a Moth Chemosensory Protein"
70:
42:. OBPs are characterized by a specific protein domain that comprises six
35:
1929:
1860:
1462:
Li, Zhengzheng; Ni, Jinfei D.; Huang, Jia; Montell, Craig (2014-09-25).
1424:
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39:
23:
1977:
1919:
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34:
of many vertebrate species and in the sensillar lymph of chemosensory
1262:
2575:
Vieira, Filipe G.; Sánchez-Gracia, Alejandro; Rozas, Julio (2007).
1595:
1844:"Organization and function of Drosophila odorant binding proteins"
66:
31:
1842:
Larter, Nikki K; Sun, Jennifer S; Carlson, John R (2016-11-15).
1637:"Quantitative analysis of pheromone-binding protein specificity"
1521:
van der Goes van Naters, Wynand; Carlson, John R. (April 2007).
838:
Vogt, R. G.; Riddiford, L. M.; Prestwich, G. D. (1985-12-01).
326:
Pelosi, P.; Baldaccini, N. E.; Pisanelli, A. M. (1982-01-01).
233:
1184:
Swarup, S.; Williams, T. I.; Anholt, R. R. H. (2011-06-14).
223:) are arranged in small clusters from 2 to 6 OBP genes. The
2470:Forêt, Sylvain; Maleszka, Ryszard (November 2006).
1523:"Receptors and Neurons for Fly Odors in Drosophila"
2123:
2121:
470:
468:
149:which has not been previously reported for OBPs.
100:family. They are structurally characterized by a
905:Wojtasek, Hubert; Leal, Walter S. (1999-10-22).
844:Proceedings of the National Academy of Sciences
423:Graham, Laurie A; Davies, Peter L (June 2002).
1011:Vieira, Filipe G.; Rozas, Julio (2011-01-01).
2455:: CS1 maint: DOI inactive as of April 2024 (
8:
2246:Galindo, K.; Smith, D. P. (November 2001).
2610:
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2529:Insect Biochemistry and Molecular Biology
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733:Insect Biochemistry and Molecular Biology
702:
636:
541:
492:
440:
359:
96:. In vertebrates, OBPs are a part of the
236:and are totally absent in some species.
211:), whereas it ranges from 52 members in
26:secreted by auxiliary cells surrounding
22:(OBPs) are small (10 to 30 kDa) soluble
272:
2448:
405:
394:
2570:
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1002:
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278:
276:
2082:The Journal of Biological Chemistry
65:of terrestrial animals exist in an
1314:10.1111/j.1432-1033.1995.tb20864.x
160:OBPs are numerous and diverse. In
14:
1653:10.1111/j.1365-2583.2012.01167.x
1302:European Journal of Biochemistry
1202:10.1111/j.1601-183x.2011.00704.x
246:Insect pheromone-binding protein
911:Journal of Biological Chemistry
530:Journal of Biological Chemistry
578:Trends in Biochemical Sciences
1:
2095:10.1016/S0021-9258(17)34013-9
1812:10.1016/s0014-5793(03)01521-7
494:10.1016/s1074-5521(00)00078-8
442:10.1016/s0378-1119(02)00672-8
125:OBPs in olfactory perception
2321:10.1016/j.neuron.2013.06.025
2206:10.1371/journal.pone.0069412
2142:10.1016/0896-6273(94)90150-3
2036:10.1371/journal.pgen.1004810
1742:Journal of Molecular Biology
1481:10.1371/journal.pgen.1004600
1087:10.1371/journal.pone.0009471
1017:Genome Biology and Evolution
976:10.1016/j.neuron.2004.12.031
798:10.1371/journal.pbio.1001546
172:in tissues such as the gut.
2264:10.1093/genetics/159.3.1059
1133:Journal of Chemical Ecology
631:(Supplement 1): i291–i292.
2662:
2541:10.1016/j.ibmb.2006.09.009
1364:10.1016/j.cell.2008.04.046
745:10.1016/j.ibmb.2018.05.001
590:10.1016/j.tibs.2004.03.003
179:and other insect species (
79:pheromone binding proteins
28:olfactory receptor neurons
2594:10.1186/gb-2007-8-11-r235
1754:10.1016/j.jmb.2007.12.063
1539:10.1016/j.cub.2007.02.043
1190:Genes, Brain and Behavior
1145:10.1007/s10886-010-9762-x
619:Pelosi, P. (2005-01-01).
261:Olfactory receptor neuron
2415:Cell and Tissue Research
2363:Cell and Tissue Research
1641:Insect Molecular Biology
924:10.1074/jbc.274.43.30950
687:10.1021/acsomega.9b03157
20:Odorant-binding proteins
2429:(inactive 2024-04-27).
865:10.1073/pnas.82.24.8827
481:Chemistry & Biology
332:The Biochemical Journal
285:Journal of Neurobiology
543:10.1074/jbc.M204371200
404:Cite journal requires
30:, including the nasal
2427:10.1007/s004410050059
2375:10.1007/s004410100388
638:10.1093/chemse/bjh229
297:10.1002/neu.480220108
170:ectopically expressed
175:Genomic analysis of
135:cis-vaccenyl acetate
58:of sensory neurons.
2197:2013PLoSO...869412S
2088:(23): 16340–16347.
1861:10.7554/elife.20242
1425:10.1038/nature06328
1417:2007Natur.450..289B
1255:1981Natur.293..161V
1078:2010PLoSO...5.9471B
917:(43): 30950–30956.
856:1985PNAS...82.8827V
681:(27): 22475–22486.
536:(35): 32094–32098.
389:10.2210/pdb1ci0/pdb
73:that are primarily
67:aqueous environment
63:olfactory receptors
52:olfactory receptors
2488:10.1101/gr.5075706
1907:Biological Reviews
1029:10.1093/gbe/evr033
256:Olfactory receptor
207:) to 66 genes (in
200:Triboliumcastaneum
104:motif composed of
94:primary structures
2482:(11): 1404–1413.
1978:10.1101/gr.239402
1920:10.1111/brv.12339
1707:10.1021/bi0516576
1411:(7167): 289–293.
1249:(5828): 161–163.
850:(24): 8827–8831.
344:10.1042/bj2010245
232:, even among the
182:Anopheles gambiae
2653:
2641:Olfactory system
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2258:(3): 1059–1072.
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902:
896:
895:
885:
867:
835:
829:
828:
818:
800:
776:
765:
764:
723:
717:
716:
706:
665:
659:
658:
640:
616:
610:
609:
573:
564:
563:
545:
521:
515:
514:
496:
472:
463:
462:
444:
420:
414:
413:
407:
402:
400:
392:
380:
374:
373:
363:
323:
317:
316:
280:
46:joined by three
2661:
2660:
2656:
2655:
2654:
2652:
2651:
2650:
2631:
2630:
2629:
2628:
2574:
2573:
2564:
2526:
2525:
2521:
2476:Genome Research
2469:
2468:
2464:
2447:
2411:
2410:
2406:
2359:
2358:
2354:
2302:
2301:
2297:
2245:
2244:
2240:
2178:
2177:
2173:
2127:
2126:
2119:
2075:
2074:
2070:
2016:
2015:
2011:
1966:Genome Research
1959:
1958:
1954:
1900:
1899:
1895:
1841:
1840:
1836:
1792:
1791:
1787:
1735:
1734:
1730:
1691:
1690:
1686:
1634:
1633:
1629:
1577:
1576:
1572:
1527:Current Biology
1520:
1519:
1515:
1474:(9): e1004600.
1461:
1460:
1456:
1402:
1401:
1397:
1345:
1344:
1337:
1299:
1298:
1294:
1240:
1239:
1235:
1183:
1182:
1178:
1126:
1125:
1121:
1059:
1058:
1054:
1010:
1009:
1000:
956:
955:
948:
904:
903:
899:
837:
836:
832:
791:(4): e1001546.
778:
777:
768:
725:
724:
720:
667:
666:
662:
625:Chemical Senses
618:
617:
613:
575:
574:
567:
523:
522:
518:
474:
473:
466:
422:
421:
417:
403:
393:
382:
381:
377:
325:
324:
320:
282:
281:
274:
269:
242:
158:
122:
90:
17:
12:
11:
5:
2659:
2657:
2649:
2648:
2643:
2633:
2632:
2627:
2626:
2581:Genome Biology
2562:
2519:
2462:
2421:(1): 181–192.
2404:
2369:(3): 423–437.
2352:
2315:(4): 725–737.
2295:
2238:
2171:
2117:
2068:
2009:
1952:
1913:(1): 184–200.
1893:
1834:
1805:(1–3): 23–26.
1785:
1728:
1684:
1627:
1596:10.1038/nsb960
1590:(9): 694–700.
1570:
1533:(7): 606–612.
1513:
1454:
1395:
1335:
1308:(3): 706–711.
1292:
1233:
1196:(6): 648–657.
1176:
1139:(3): 245–248.
1119:
1052:
998:
969:(2): 193–200.
946:
897:
830:
766:
718:
660:
611:
584:(5): 257–264.
565:
516:
487:(2): 143–151.
464:
435:(1–2): 43–55.
415:
406:|journal=
375:
338:(1): 245–248.
318:
271:
270:
268:
265:
264:
263:
258:
253:
248:
241:
238:
188:Apis mellifera
157:
154:
121:
118:
89:
86:
15:
13:
10:
9:
6:
4:
3:
2:
2658:
2647:
2644:
2642:
2639:
2638:
2636:
2622:
2618:
2613:
2608:
2604:
2600:
2595:
2590:
2586:
2582:
2578:
2571:
2569:
2567:
2563:
2558:
2554:
2550:
2546:
2542:
2538:
2534:
2530:
2523:
2520:
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2501:
2497:
2493:
2489:
2485:
2481:
2477:
2473:
2466:
2463:
2458:
2452:
2444:
2440:
2436:
2432:
2428:
2424:
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2416:
2408:
2405:
2400:
2396:
2392:
2388:
2384:
2380:
2376:
2372:
2368:
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2348:
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2339:
2334:
2330:
2326:
2322:
2318:
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2310:
2306:
2299:
2296:
2291:
2287:
2282:
2277:
2273:
2269:
2265:
2261:
2257:
2253:
2249:
2242:
2239:
2234:
2230:
2225:
2220:
2216:
2212:
2207:
2202:
2198:
2194:
2191:(7): e69412.
2190:
2186:
2182:
2175:
2172:
2167:
2163:
2159:
2155:
2151:
2147:
2143:
2139:
2135:
2131:
2124:
2122:
2118:
2113:
2109:
2105:
2101:
2096:
2091:
2087:
2083:
2079:
2072:
2069:
2064:
2060:
2055:
2050:
2046:
2042:
2037:
2032:
2028:
2024:
2023:PLOS Genetics
2020:
2013:
2010:
2005:
2001:
1996:
1991:
1987:
1983:
1979:
1975:
1971:
1967:
1963:
1956:
1953:
1948:
1944:
1940:
1936:
1931:
1926:
1921:
1916:
1912:
1908:
1904:
1897:
1894:
1889:
1885:
1880:
1875:
1871:
1867:
1862:
1857:
1853:
1849:
1845:
1838:
1835:
1830:
1826:
1822:
1818:
1813:
1808:
1804:
1800:
1796:
1789:
1786:
1781:
1777:
1772:
1767:
1763:
1759:
1755:
1751:
1747:
1743:
1739:
1732:
1729:
1724:
1720:
1716:
1712:
1708:
1704:
1700:
1696:
1688:
1685:
1680:
1676:
1671:
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1658:
1654:
1650:
1646:
1642:
1638:
1631:
1628:
1623:
1619:
1614:
1609:
1605:
1601:
1597:
1593:
1589:
1585:
1581:
1574:
1571:
1566:
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1557:
1552:
1548:
1544:
1540:
1536:
1532:
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1514:
1509:
1505:
1500:
1495:
1491:
1487:
1482:
1477:
1473:
1469:
1468:PLOS Genetics
1465:
1458:
1455:
1450:
1446:
1442:
1438:
1434:
1430:
1426:
1422:
1418:
1414:
1410:
1406:
1399:
1396:
1391:
1387:
1382:
1377:
1373:
1369:
1365:
1361:
1357:
1353:
1349:
1342:
1340:
1336:
1331:
1327:
1323:
1319:
1315:
1311:
1307:
1303:
1296:
1293:
1288:
1284:
1280:
1276:
1272:
1268:
1264:
1260:
1256:
1252:
1248:
1244:
1237:
1234:
1229:
1225:
1220:
1215:
1211:
1207:
1203:
1199:
1195:
1191:
1187:
1180:
1177:
1172:
1168:
1163:
1158:
1154:
1150:
1146:
1142:
1138:
1134:
1130:
1123:
1120:
1115:
1111:
1106:
1101:
1097:
1093:
1088:
1083:
1079:
1075:
1071:
1067:
1063:
1056:
1053:
1048:
1044:
1039:
1034:
1030:
1026:
1022:
1018:
1014:
1007:
1005:
1003:
999:
994:
990:
986:
982:
977:
972:
968:
964:
960:
953:
951:
947:
942:
938:
934:
930:
925:
920:
916:
912:
908:
901:
898:
893:
889:
884:
879:
875:
871:
866:
861:
857:
853:
849:
845:
841:
834:
831:
826:
822:
817:
812:
808:
804:
799:
794:
790:
786:
782:
775:
773:
771:
767:
762:
758:
754:
750:
746:
742:
738:
734:
730:
722:
719:
714:
710:
705:
700:
696:
692:
688:
684:
680:
676:
672:
664:
661:
656:
652:
648:
644:
639:
634:
630:
626:
622:
615:
612:
607:
603:
599:
595:
591:
587:
583:
579:
572:
570:
566:
561:
557:
553:
549:
544:
539:
535:
531:
527:
520:
517:
512:
508:
504:
500:
495:
490:
486:
482:
478:
471:
469:
465:
460:
456:
452:
448:
443:
438:
434:
430:
426:
419:
416:
411:
398:
390:
386:
379:
376:
371:
367:
362:
357:
353:
349:
345:
341:
337:
333:
329:
322:
319:
314:
310:
306:
302:
298:
294:
290:
286:
279:
277:
273:
266:
262:
259:
257:
254:
252:
249:
247:
244:
243:
239:
237:
235:
231:
226:
222:
218:
214:
210:
206:
202:
201:
196:
195:
191:
189:
184:
183:
178:
173:
171:
167:
163:
155:
153:
150:
147:
142:
140:
136:
132:
128:
119:
117:
114:
110:
107:
103:
99:
95:
87:
85:
82:
80:
76:
72:
69:, yet detect
68:
64:
59:
57:
56:cell membrane
53:
49:
45:
41:
37:
33:
29:
25:
21:
2587:(11): R235.
2584:
2580:
2535:(1): 19–28.
2532:
2528:
2522:
2479:
2475:
2465:
2451:cite journal
2418:
2414:
2407:
2366:
2362:
2355:
2312:
2308:
2298:
2255:
2251:
2241:
2188:
2184:
2174:
2136:(1): 35–49.
2133:
2129:
2085:
2081:
2071:
2026:
2022:
2012:
1969:
1965:
1955:
1930:2158/1089933
1910:
1906:
1896:
1851:
1847:
1837:
1802:
1799:FEBS Letters
1798:
1788:
1745:
1741:
1731:
1698:
1695:Biochemistry
1694:
1687:
1647:(1): 31–40.
1644:
1640:
1630:
1587:
1583:
1573:
1530:
1526:
1516:
1471:
1467:
1457:
1408:
1404:
1398:
1355:
1351:
1305:
1301:
1295:
1246:
1242:
1236:
1193:
1189:
1179:
1136:
1132:
1122:
1072:(3): e9471.
1069:
1065:
1055:
1020:
1016:
966:
962:
914:
910:
900:
847:
843:
833:
788:
785:PLOS Biology
784:
736:
732:
721:
678:
674:
663:
628:
624:
614:
581:
577:
533:
529:
519:
484:
480:
432:
428:
418:
397:cite journal
378:
335:
331:
321:
291:(1): 74–84.
288:
284:
224:
220:
217:T. castaneum
216:
212:
208:
204:
198:
192:
186:
180:
176:
174:
161:
159:
151:
145:
143:
138:
130:
126:
123:
106:antiparallel
91:
83:
60:
19:
18:
1023:: 476–490.
194:Bombyx mori
75:hydrophobic
2646:Lipocalins
2635:Categories
267:References
230:arthropods
225:Drosophila
221:Drosophila
213:Drosophila
209:A. gambiae
177:Drosophila
162:Drosophila
156:Expression
146:Drosophila
131:Drosophila
2603:1474-760X
2549:0965-1748
2496:1088-9051
2435:0302-766X
2383:0302-766X
2329:0896-6273
2272:0016-6731
2215:1932-6203
2150:0896-6273
2104:0021-9258
2045:1553-7404
1986:1088-9051
1939:1469-185X
1870:2050-084X
1821:0014-5793
1762:0022-2836
1715:0006-2960
1661:0962-1075
1604:1545-9993
1547:0960-9822
1490:1553-7404
1433:0028-0836
1372:0092-8674
1322:0014-2956
1271:0028-0836
1210:1601-1848
1153:0098-0331
1096:1932-6203
985:0896-6273
933:0021-9258
874:0027-8424
807:1545-7885
739:: 48–61.
695:2470-1343
675:ACS Omega
647:0379-864X
598:0968-0004
552:0021-9258
503:1074-5521
451:0378-1119
352:0264-6021
305:0022-3034
234:dipterans
215:to 20 in
205:mellifera
113:α-helical
98:lipocalin
88:Structure
48:disulfide
44:α-helices
2621:18039354
2557:17175443
2514:17065610
2443:10805087
2399:23354983
2391:11456419
2347:23972598
2290:11729153
2252:Genetics
2233:23861970
2185:PLOS ONE
2166:15776205
2063:25412082
2004:12213773
1947:28480618
1888:27845621
1829:14759510
1780:18234222
1723:16460016
1679:23121132
1622:12881720
1565:17363256
1508:25255106
1441:17943085
1390:18585358
1279:18074618
1228:21605338
1171:20191395
1114:20208991
1066:PLOS ONE
1047:21527792
993:15664171
941:10521490
825:23637570
761:21670580
753:29751047
713:31909330
655:15738163
606:15130562
560:12068017
511:10662696
459:12119098
240:See also
139:in vitro
120:Function
109:β-sheets
102:β-barrel
71:odorants
36:sensilla
24:proteins
2612:2258175
2505:1626642
2338:3753695
2281:1461854
2224:3702612
2193:Bibcode
2158:7545907
2112:8206941
2054:4238959
1879:5127637
1771:2293277
1670:3552018
1613:4397894
1556:1876700
1499:4177743
1449:4402715
1413:Bibcode
1381:4397981
1330:7588707
1287:4361816
1251:Bibcode
1219:3150612
1162:2837830
1105:2830424
1074:Bibcode
1038:3134979
892:3001718
852:Bibcode
816:3640100
704:6941369
370:7082286
361:1163633
313:2010751
251:Odorant
127:in vivo
54:in the
40:insects
2619:
2609:
2601:
2555:
2547:
2512:
2502:
2494:
2441:
2433:
2397:
2389:
2381:
2345:
2335:
2327:
2309:Neuron
2288:
2278:
2270:
2231:
2221:
2213:
2164:
2156:
2148:
2130:Neuron
2110:
2102:
2061:
2051:
2043:
2002:
1995:186648
1992:
1984:
1945:
1937:
1886:
1876:
1868:
1827:
1819:
1778:
1768:
1760:
1721:
1713:
1677:
1667:
1659:
1620:
1610:
1602:
1563:
1553:
1545:
1506:
1496:
1488:
1447:
1439:
1431:
1405:Nature
1388:
1378:
1370:
1328:
1320:
1285:
1277:
1269:
1243:Nature
1226:
1216:
1208:
1169:
1159:
1151:
1112:
1102:
1094:
1045:
1035:
991:
983:
963:Neuron
939:
931:
890:
883:391531
880:
872:
823:
813:
805:
759:
751:
711:
701:
693:
653:
645:
604:
596:
558:
550:
509:
501:
457:
449:
368:
358:
350:
311:
303:
197:, and
2395:S2CID
2162:S2CID
1848:eLife
1445:S2CID
1283:S2CID
757:S2CID
166:mRNAs
32:mucus
2617:PMID
2599:ISSN
2553:PMID
2545:ISSN
2510:PMID
2492:ISSN
2457:link
2439:PMID
2431:ISSN
2387:PMID
2379:ISSN
2343:PMID
2325:ISSN
2286:PMID
2268:ISSN
2229:PMID
2211:ISSN
2154:PMID
2146:ISSN
2108:PMID
2100:ISSN
2059:PMID
2041:ISSN
2000:PMID
1982:ISSN
1943:PMID
1935:ISSN
1884:PMID
1866:ISSN
1825:PMID
1817:ISSN
1776:PMID
1758:ISSN
1719:PMID
1711:ISSN
1675:PMID
1657:ISSN
1618:PMID
1600:ISSN
1561:PMID
1543:ISSN
1504:PMID
1486:ISSN
1437:PMID
1429:ISSN
1386:PMID
1368:ISSN
1352:Cell
1326:PMID
1318:ISSN
1275:PMID
1267:ISSN
1224:PMID
1206:ISSN
1167:PMID
1149:ISSN
1110:PMID
1092:ISSN
1043:PMID
989:PMID
981:ISSN
937:PMID
929:ISSN
888:PMID
870:ISSN
821:PMID
803:ISSN
749:PMID
709:PMID
691:ISSN
651:PMID
643:ISSN
602:PMID
594:ISSN
556:PMID
548:ISSN
507:PMID
499:ISSN
455:PMID
447:ISSN
429:Gene
410:help
366:PMID
348:ISSN
309:PMID
301:ISSN
61:The
2607:PMC
2589:doi
2537:doi
2500:PMC
2484:doi
2423:doi
2419:300
2371:doi
2367:304
2333:PMC
2317:doi
2276:PMC
2260:doi
2256:159
2219:PMC
2201:doi
2138:doi
2090:doi
2086:269
2049:PMC
2031:doi
1990:PMC
1974:doi
1925:hdl
1915:doi
1874:PMC
1856:doi
1807:doi
1803:558
1766:PMC
1750:doi
1746:376
1703:doi
1665:PMC
1649:doi
1608:PMC
1592:doi
1551:PMC
1535:doi
1494:PMC
1476:doi
1421:doi
1409:450
1376:PMC
1360:doi
1356:133
1310:doi
1306:232
1259:doi
1247:293
1214:PMC
1198:doi
1157:PMC
1141:doi
1100:PMC
1082:doi
1033:PMC
1025:doi
971:doi
919:doi
915:274
878:PMC
860:doi
811:PMC
793:doi
741:doi
699:PMC
683:doi
633:doi
586:doi
538:doi
534:277
489:doi
437:doi
433:292
385:doi
356:PMC
340:doi
336:201
293:doi
38:of
2637::
2615:.
2605:.
2597:.
2583:.
2579:.
2565:^
2551:.
2543:.
2533:37
2531:.
2508:.
2498:.
2490:.
2480:16
2478:.
2474:.
2453:}}
2449:{{
2437:.
2417:.
2393:.
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