2053:
450:
All three marketed orexin antagonists do not need to be dose adjusted in patients with reduced renal function, as the pharmacokinetic profiles of these medications are not significantly affected. In patients with moderate to severe hepatic impairment, dose adjustments of these medications may be
446:
The pharmacokinetics of suvorexant are significantly affected by age, sex, and other factors, leading to increased blood concentrations in female, obese, and older patients. These factors do not significantly affect the pharmacokinetics of lemborexant or daridorexant.
1656:
Preskorn SH (January 2023). "Comparative
Pharmacology of the 3 Marketed Dual Orexin Antagonists-Daridorexant, Lemborexant, and Suvorexant-Part 2. Principal Drug Metabolizing Enzyme, Drug-Drug Interactions, and Effects of Liver and Renal Impairment on Metabolism".
654:
Preskorn SH (January 2023). "Comparative
Pharmacology of the 3 Marketed Dual Orexin Antagonists-Daridorexant, Lemborexant, and Suvorexant-Part 2. Principal Drug Metabolizing Enzyme, Drug-Drug Interactions, and Effects of Liver and Renal Impairment on Metabolism".
1086:
Rodgers RJ, Halford JC, Nunes de Souza RL, Canto de Souza AL, Piper DC, Arch JR, et al. (April 2001). "SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats".
111:
antagonist – approved for insomnia in
December 2019 and released June 1 2020, under development for circadian rhythm sleep disorders, chronic obstructive pulmonary disease, and sleep apnea – half-life 17–55
1133:
Xue T, Wu X, Chen S, Yang Y, Yan Z, Song Z, et al. (February 2022). "The efficacy and safety of dual orexin receptor antagonists in primary insomnia: A systematic review and network meta-analysis".
1751:
Muehlan C, Vaillant C, Zenklusen I, Kraehenbuehl S, Dingemanse J (November 2020). "Clinical pharmacology, efficacy, and safety of orexin receptor antagonists for the treatment of insomnia disorders".
822:
Muehlan C, Vaillant C, Zenklusen I, Kraehenbuehl S, Dingemanse J (November 2020). "Clinical pharmacology, efficacy, and safety of orexin receptor antagonists for the treatment of insomnia disorders".
1987:
Shariq AS, Rosenblat JD, Alageel A, Mansur RB, Rong C, Ho RC, et al. (June 2019). "Evaluating the role of orexins in the pathophysiology and treatment of depression: A comprehensive review".
1280:
Kishi T, Nomura I, Matsuda Y, Sakuma K, Okuya M, Ikuta T, et al. (September 2020). "Lemborexant vs suvorexant for insomnia: A systematic review and network meta-analysis".
2085:
2035:
for "A Six Week, Randomized, Double-Blind
Placebo-Controlled, Suvorexant Augmentation Study of Antidepressant Treatment of Major Depressive Disorder With Residual Insomnia" at
2449:
519:
4066:
3471:
4083:
2078:
774:
Keks NA, Hope J (August 2022). "Lemborexant, an orexin receptor antagonist sedative-hypnotic: Is it useful for insomnia in psychiatric disorders?".
1845:"Orexin/hypocretin receptor modulation of anxiolytic and antidepressive responses during social stress and decision-making: Potential for therapy"
435:, and 6 to 10 hours for daridorexant. The elimination half-lives of investigational orexin receptor antagonists are 2 to 3 hours for
4802:
2442:
2057:
520:"Targeting Orexin Receptors for the Treatment of Insomnia: From Physiological Mechanisms to Current Clinical Evidence and Recommendations"
2071:
383:
Rates of somnolence or fatigue with orexin receptor antagonists in clinical trials were 7% (vs. 3% with placebo) for suvorexant 15 to 20
4059:
920:
Tian Y, Qin Z, Han Y (March 2022). "Suvorexant with or without ramelteon to prevent delirium: a systematic review and meta-analysis".
3176:
2435:
1452:
1426:
1180:
Kuriyama A, Tabata H (October 2017). "Suvorexant for the treatment of primary insomnia: A systematic review and meta-analysis".
2258:
2105:
1555:"0146 Efficacy and Safety of Single Dose of TS-142, a Novel and Potent Dual Orexin Receptor Antagonist, in Insomnia Patients"
143:
antagonist – under development for major depressive disorder, insomnia, and sleep apnea, up to phase 3 – half-life 2–3 hours
58:
51:
4052:
1607:"A Comprehensive Review of Daridorexant, a Dual-Orexin Receptor Antagonist as New Approach for the Treatment of Insomnia"
718:"A Comprehensive Review of Daridorexant, a Dual-Orexin Receptor Antagonist as New Approach for the Treatment of Insomnia"
1487:
361:
4846:
4819:
3947:
3597:
606:
Cao M, Guilleminault C (April 2011). "Hypocretin and its emerging role as a target for treatment of sleep disorders".
524:
303:
4778:
4540:
4502:
4482:
3702:
3516:
97:
antagonist – approved for insomnia in
January 2022, formerly under development for sleep apnea – half-life 8 hours
4318:
3353:
471:
1944:
Jacobson LH, Hoyer D, de Lecea L (May 2022). "Hypocretins (orexins): The ultimate translational neuropeptides".
1220:"Suvorexant for Primary Insomnia: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials"
4760:
4464:
3679:
3493:
1478:
46:
of one (selective orexin receptor antagonist or SORA) or both (dual orexin receptor antagonis or DORA) of the
571:
Roecker AJ, Coleman PJ (2008). "Orexin receptor antagonists: medicinal chemistry and therapeutic potential".
4807:
1379:"A network meta-analysis of the long- and short-term efficacy of sleep medicines in adults and older adults"
3925:
4548:
3812:
3751:
3565:
2525:
431:, about 17 to 19 hours ("effective" half-life) or 55 hours (terminal elimination half-life) for
424:
307:
3733:
3547:
126:
antagonist – approved for insomnia in August 2014, under development for delirium – half-life 12 hours
3882:
3400:
1231:
326:
3259:
4712:
4666:
4235:
3368:
3363:
2930:
2487:
463:
43:
2356:
2193:
157:
antagonist – under development for insomnia and sleep apnea, up to phase 2 – half-life 1.5–3 hours
4596:
3799:
3229:
3145:
2510:
2311:
2097:
2036:
2012:
1969:
1796:"An Update on Dual Orexin Receptor Antagonists and Their Potential Role in Insomnia Therapeutics"
1776:
1682:
1576:
1535:
1408:
1305:
1159:
1112:
945:
847:
799:
680:
631:
2920:
2316:
2277:
1510:
Earl DC, Van Tyle KM (November 2020). "New pharmacologic agents for insomnia and hypersomnia".
1479:"Quviviq (daridorexant) tablets, for oral use, [controlled substance schedule pending]"
4279:
4243:
4201:
3192:
3150:
2983:
2910:
2658:
2653:
2406:
2238:
2173:
2168:
2004:
1961:
1923:
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1400:
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373:
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2183:
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4439:
3333:
2943:
2287:
2272:
2129:
2124:
1996:
1953:
1913:
1905:
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1815:
1807:
1760:
1723:
1713:
1666:
1628:
1618:
1566:
1519:
1390:
1349:
1339:
1328:"Comparative efficacy of lemborexant and other insomnia treatments: a network meta-analysis"
1289:
1249:
1239:
1189:
1143:
1096:
986:
976:
929:
889:
881:
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783:
739:
729:
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407:
330:
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311:
2119:
4610:
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3918:
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3418:
3296:
3214:
3209:
3187:
3069:
2578:
2243:
2094:
494:
486:
369:
299:
47:
17:
1553:
Uchiyama M, Kambe D, Imadera Y, Sunaga H, Hasegawa S, Nogi T, et al. (April 2020).
1354:
1327:
1235:
4813:
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4590:
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4283:
4098:
3738:
3666:
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1254:
1219:
991:
964:
894:
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717:
548:
498:
490:
478:
65:
518:
Mogavero MP, Silvani A, Lanza G, DelRosso LM, Ferini-Strambi L, Ferri R (2023-01-22).
4840:
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4732:
4638:
4574:
4468:
4429:
4368:
4353:
4343:
4304:
4265:
4261:
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3991:
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3102:
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2515:
2321:
1973:
1780:
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1539:
1412:
1309:
1293:
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1100:
949:
851:
803:
684:
319:
2016:
1395:
1378:
1116:
635:
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4772:
4601:
4510:
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2188:
1860:
1068:
1050:
1032:
1014:
698:
229:
86:
2031:
1764:
1326:
McElroy H, O'Leary B, Adena M, Campbell R, Monfared AA, Meier G (September 2021).
835:
485:
is under development for treatment of major depressive disorder however and is in
1670:
1523:
1244:
668:
4782:
4699:
4680:
4633:
4606:
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4558:
4530:
4520:
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2613:
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2500:
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2000:
1571:
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885:
482:
440:
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432:
353:
191:
146:
136:
100:
1909:
1193:
1147:
584:
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4708:
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4614:
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4113:
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4013:
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2401:
2366:
2361:
2341:
2336:
2331:
2233:
2213:
2203:
2198:
2163:
2158:
2153:
1894:"Orexin Receptor Antagonists as Emerging Treatments for Psychiatric Disorders"
1623:
787:
734:
619:
459:
428:
403:
357:
277:
215:
201:
177:
167:
115:
2427:
2063:
1588:
1580:
1344:
4755:
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4684:
4661:
4628:
4553:
4424:
4289:
4225:
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4168:
4128:
4023:
3817:
3707:
3674:
3609:
3521:
3486:
3438:
3281:
3234:
3041:
3026:
3016:
3006:
2915:
2877:
2867:
2859:
2844:
2801:
2791:
2786:
2756:
2711:
2648:
2583:
2228:
2223:
2218:
475:
377:
267:
261:
249:
239:
2008:
1965:
1927:
1878:
1829:
1772:
1737:
1678:
1642:
1531:
1404:
1363:
1301:
1263:
1201:
1155:
1108:
1000:
941:
903:
843:
795:
753:
676:
627:
592:
557:
2052:
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4744:
4688:
4650:
4622:
4220:
4215:
4183:
4133:
4075:
4007:
3998:
3892:
3644:
3373:
3343:
3269:
3204:
3059:
3036:
3031:
2996:
2849:
2781:
2643:
2558:
2462:
2458:
2305:
2301:
2142:
2138:
501:
therapy in people with major depressive disorder and residual insomnia.
467:
365:
342:
257:
69:
1718:
1015:"Seltorexant - Janssen Research & Development/Minerva Neurosciences"
981:
538:
4768:
4472:
4275:
4247:
4044:
3952:
3689:
3503:
3378:
3274:
3181:
2900:
2633:
1957:
1377:
Wang L, Pan Y, Ye C, Guo L, Luo S, Dai S, et al. (December 2021).
933:
1843:
Summers CH, Yaeger JD, Staton CD, Arendt DH, Summers TR (March 2020).
1811:
462:
was studied for but was not found to be effective in the treatment of
4676:
4205:
4003:
3155:
3051:
2297:
2134:
427:
of clinically used orexin receptor antagonists are 12 hours for
39:
226:
antagonist – was in development for potential use in sleep disorders
188:
antagonist – development of the drug was abandoned in
January 2011
4028:
3348:
4656:
4309:
2495:
1989:
Progress in Neuro-Psychopharmacology & Biological
Psychiatry
1605:
Ziemichód W, Grabowska K, Kurowska A, Biała G (September 2022).
716:
Ziemichód W, Grabowska K, Kurowska A, Biała G (September 2022).
4048:
2431:
2067:
391:
mg, and 5 to 6% (vs. 4% with placebo) for daridorexant 25 to 50
870:"Suvorexant for the prevention of delirium: A meta-analysis"
406:, a neurological disorder caused by orexin deficiency, is a
387:
mg, 7 to 10% (vs. 1.3% for placebo) for lemborexant 5 to 10
1794:
Janto K, Prichard JR, Pusalavidyasagar S (August 2018).
341:
Suvorexant appears to be effective in the prevention of
325:
Orexin receptor antagonists are not currently used as
3868:
1702:"Profile of suvorexant in the management of insomnia"
965:"Profile of suvorexant in the management of insomnia"
489:
trials for this indication. Also, suvorexant is in a
329:
for insomnia due to cost and concerns about possible
4567:
4539:
4501:
4367:
4082:
3906:
3859:
3831:
3798:
3778:
3724:
3665:
3653:
3596:
3538:
3462:
3399:
3387:
3316:
3164:
3101:
3068:
3050:
2982:
2929:
2886:
2858:
2800:
2677:
2534:
2486:
2474:
2257:
2104:
1753:Expert Opinion on Drug Metabolism & Toxicology
824:Expert Opinion on Drug Metabolism & Toxicology
212:antagonist – development was discontinued in 2015
1600:
1598:
1332:Journal of Managed Care & Specialty Pharmacy
1939:
1937:
1321:
1319:
1275:
1273:
1213:
1211:
1175:
1173:
1128:
1126:
915:
913:
649:
647:
645:
139:(MIN-202, JNJ-42847922, JNJ-922) – selective OX
863:
861:
817:
815:
813:
4060:
3472:Serotonin antagonists and reuptake inhibitors
2443:
2079:
8:
4616:
64:. Medical applications include treatment of
4725:
4713:
3861:
1892:Han Y, Yuan K, Zheng Y, Lu L (April 2020).
769:
767:
765:
763:
4067:
4053:
4045:
3662:
3396:
2483:
2450:
2436:
2428:
2086:
2072:
2064:
1453:"Dayvigo- lemborexant tablet, film coated"
1427:"Belsomra- suvorexant tablet, film coated"
608:Current Neurology and Neuroscience Reports
1917:
1868:
1819:
1727:
1717:
1632:
1622:
1570:
1394:
1353:
1343:
1253:
1243:
990:
980:
893:
868:Xu S, Cui Y, Shen J, Wang P (July 2020).
743:
733:
547:
537:
699:"Daridorexant - Idorsia Pharmaceuticals"
38:, is a drug that inhibits the effect of
510:
356:of orexin receptor antagonists include
256:antagonist – has been shown to produce
1383:Neuroscience and Biobehavioral Reviews
1218:Kishi T, Matsunaga S, Iwata N (2015).
1512:Current Opinion in Pulmonary Medicine
1033:"Vornorexant - Taisho Pharmaceutical"
573:Current Topics in Medicinal Chemistry
7:
1706:Drug Design, Development and Therapy
1089:The European Journal of Neuroscience
969:Drug Design, Development and Therapy
1459:. U.S. National Library of Medicine
1433:. U.S. National Library of Medicine
302:improve sleep parameters including
1800:Journal of Clinical Sleep Medicine
439:and about 1.5 to 3 hours for
410:to the use of orexin antagonists.
25:
3177:Acetylglycinamide chloral hydrate
1075:. Springer Nature Switzerland AG.
1057:. Springer Nature Switzerland AG.
1039:. Springer Nature Switzerland AG.
1021:. Springer Nature Switzerland AG.
705:. Springer Nature Switzerland AG.
2051:
1294:10.1016/j.jpsychires.2020.05.025
1101:10.1046/j.0953-816x.2001.01518.x
280:– first non-peptide selective OX
252:– first non-peptide selective OX
1659:Journal of Psychiatric Practice
1396:10.1016/j.neubiorev.2021.09.035
1282:Journal of Psychiatric Research
657:Journal of Psychiatric Practice
362:daytime sleepiness and sedation
89:(nemorexant; Quviviq) – dual OX
2417:Vornorexant (ORN-0829, TS-142)
2249:Vornorexant (ORN-0829, TS-142)
2244:Tebideutorexant (JNJ-61393215)
1861:10.1016/j.brainres.2018.12.036
1:
1765:10.1080/17425255.2020.1817380
836:10.1080/17425255.2020.1817380
1946:Journal of Internal Medicine
1671:10.1097/PRA.0000000000000690
1524:10.1097/MCP.0000000000000722
1488:Food and Drug Administration
1245:10.1371/journal.pone.0136910
669:10.1097/PRA.0000000000000690
298:Orexin receptor antagonists
149:(ORN-0829, TS-142) – dual OX
4779:Tetracyclic antidepressants
4718:Tooltip 5-hydroxytryptophan
4541:Melatonin receptor agonists
4503:Orexin receptor antagonists
4483:Tetracyclic antidepressants
3703:Tetracyclic antidepressants
3517:Tetracyclic antidepressants
2058:Orexin receptor antagonists
2001:10.1016/j.pnpbp.2018.12.008
886:10.1097/MD.0000000000021043
525:Nature and Science of Sleep
304:latency to persistent sleep
4863:
1910:10.1007/s12264-019-00447-9
1194:10.1016/j.smrv.2016.09.004
1148:10.1016/j.smrv.2021.101573
585:10.2174/156802608784936746
32:orexin receptor antagonist
18:Orexin receptor antagonist
4797:
4761:Tricyclic antidepressants
4465:Tricyclic antidepressants
3680:Tricyclic antidepressants
3494:Tricyclic antidepressants
2214:Nivasorexant (ACT-539313)
1624:10.3390/molecules27186041
1572:10.1093/sleep/zsaa056.144
788:10.1177/10398562221092310
735:10.3390/molecules27186041
620:10.1007/s11910-010-0172-9
472:major depressive disorder
3265:Sulfonmethane (sulfonal)
1700:Sutton EL (2015-11-11).
1345:10.18553/jmcp.2021.21011
963:Sutton EL (2015-11-11).
3752:Atypical antipsychotics
3566:Atypical antipsychotics
2357:Fazamorexant (YZJ-1139)
2322:Suntinorexton (TAK-861)
2194:Fazamorexant (YZJ-1139)
776:Australasian Psychiatry
3926:Chlorophenylalkyldiols
3734:Typical antipsychotics
3548:Typical antipsychotics
2367:GSK-649868 (SB-649868)
2293:Firazorexton (TAK-994)
2283:Danavorexton (TAK-925)
2204:GSK-649868 (SB-649868)
2029:Clinical trial number
1182:Sleep Medicine Reviews
1136:Sleep Medicine Reviews
425:elimination half-lives
308:wake after sleep onset
180:(ACT-078573) – dual OX
1898:Neuroscience Bulletin
1565:(Supplement 1): A58.
327:first-line treatments
218:(SB-649868) – dual OX
4705:Serotonin precursors
4076:Insomnia medications
3883:Gabapentin enacarbil
2931:Neuroactive steroids
2901:Apronal (apronalide)
2174:C4X-3256 (INDV-2000)
2060:at Wikimedia Commons
493:trial for use as an
118:(Belsomra) – dual OX
4667:Menthyl isovalerate
4090:positive modulators
1719:10.2147/DDDT.S73224
1236:2015PLoSO..1036910K
982:10.2147/DDDT.S73224
539:10.2147/NSS.S201994
464:diabetic neuropathy
204:(MK-6096) – dual OX
103:(Dayvigo) – dual OX
44:receptor antagonist
4847:Orexin antagonists
4824:Never to phase III
4202:Nonbenzodiazepines
3948:Diethylpropanediol
3230:Dichloralphenazone
3146:Methylmethaqualone
2984:Nonbenzodiazepines
2511:Diethylpropanediol
2037:ClinicalTrials.gov
1958:10.1111/joim.13406
934:10.1111/psyg.12792
264:effects in animals
4834:
4833:
4280:potassium bromide
4042:
4041:
3794:
3793:
3592:
3591:
3312:
3311:
3193:Potassium bromide
3151:Nitromethaqualone
2659:Thiotetrabarbital
2506:Ethanol (alcohol)
2425:
2424:
2056:Media related to
1812:10.5664/jcsm.7282
1759:(11): 1063–1078.
830:(11): 1063–1078.
399:Contraindications
131:Under development
36:orexin antagonist
16:(Redirected from
4854:
4727:
4724:Sodium oxybate (
4719:
4715:
4618:
4440:Phenyltoloxamine
4381:inverse agonists
4334:Piperidinediones
4069:
4062:
4055:
4046:
3967:muscle relaxants
3870:
3867:
3663:
3397:
3334:4-Fluorophenibut
3070:Piperidinediones
2944:Allopregnanolone
2526:Trichloroethanol
2484:
2452:
2445:
2438:
2429:
2088:
2081:
2074:
2065:
2055:
2039:
2027:
2021:
2020:
1984:
1978:
1977:
1941:
1932:
1931:
1921:
1889:
1883:
1882:
1872:
1840:
1834:
1833:
1823:
1806:(8): 1399–1408.
1791:
1785:
1784:
1748:
1742:
1741:
1731:
1721:
1697:
1691:
1690:
1653:
1647:
1646:
1636:
1626:
1602:
1593:
1592:
1574:
1550:
1544:
1543:
1507:
1501:
1500:
1498:
1496:
1483:
1475:
1469:
1468:
1466:
1464:
1449:
1443:
1442:
1440:
1438:
1423:
1417:
1416:
1398:
1374:
1368:
1367:
1357:
1347:
1338:(9): 1296–1308.
1323:
1314:
1313:
1277:
1268:
1267:
1257:
1247:
1215:
1206:
1205:
1177:
1168:
1167:
1130:
1121:
1120:
1095:(7): 1444–1452.
1083:
1077:
1076:
1065:
1059:
1058:
1047:
1041:
1040:
1029:
1023:
1022:
1011:
1005:
1004:
994:
984:
960:
954:
953:
922:Psychogeriatrics
917:
908:
907:
897:
865:
856:
855:
819:
808:
807:
771:
758:
757:
747:
737:
713:
707:
706:
695:
689:
688:
651:
640:
639:
603:
597:
596:
568:
562:
561:
551:
541:
515:
419:Pharmacokinetics
408:contraindication
394:
390:
386:
331:misuse liability
316:total sleep time
312:sleep efficiency
300:dose-dependently
48:orexin receptors
21:
4862:
4861:
4857:
4856:
4855:
4853:
4852:
4851:
4837:
4836:
4835:
4830:
4829:
4814:Clinical trials
4793:
4717:
4563:
4535:
4497:
4405:Diphenhydramine
4379:
4376:
4363:
4300:Chloral hydrate
4244:amylene hydrate
4099:Benzodiazepines
4089:
4087:
4078:
4073:
4043:
4038:
3902:
3865:
3855:
3827:
3790:
3774:
3720:
3667:Antidepressants
3658:
3649:
3620:Dexmedetomidine
3601:
3588:
3534:
3464:Antidepressants
3458:
3419:Diphenhydramine
3392:
3383:
3321:
3308:
3297:Isovaleric acid
3260:Sulfonylalkanes
3215:Chloral hydrate
3210:Chloral betaine
3188:Lithium bromide
3160:
3097:
3064:
3046:
2978:
2925:
2882:
2854:
2796:
2679:Benzodiazepines
2673:
2579:Ethallobarbital
2530:
2479:
2470:
2456:
2426:
2421:
2262:
2253:
2109:
2100:
2095:Orexin receptor
2092:
2048:
2043:
2042:
2028:
2024:
1986:
1985:
1981:
1943:
1942:
1935:
1891:
1890:
1886:
1842:
1841:
1837:
1793:
1792:
1788:
1750:
1749:
1745:
1699:
1698:
1694:
1655:
1654:
1650:
1604:
1603:
1596:
1552:
1551:
1547:
1509:
1508:
1504:
1494:
1492:
1481:
1477:
1476:
1472:
1462:
1460:
1451:
1450:
1446:
1436:
1434:
1425:
1424:
1420:
1376:
1375:
1371:
1325:
1324:
1317:
1279:
1278:
1271:
1230:(8): e0136910.
1217:
1216:
1209:
1179:
1178:
1171:
1132:
1131:
1124:
1085:
1084:
1080:
1067:
1066:
1062:
1049:
1048:
1044:
1031:
1030:
1026:
1013:
1012:
1008:
962:
961:
957:
919:
918:
911:
867:
866:
859:
821:
820:
811:
773:
772:
761:
715:
714:
710:
697:
696:
692:
653:
652:
643:
605:
604:
600:
579:(11): 977–987.
570:
569:
565:
517:
516:
512:
507:
479:clinical trials
457:
421:
416:
401:
392:
388:
384:
370:abnormal dreams
351:
339:
296:
291:
283:
273:
255:
245:
235:
225:
221:
211:
207:
197:
187:
183:
173:
164:
156:
152:
142:
133:
125:
121:
110:
106:
96:
92:
83:
78:
66:sleep disorders
62:
55:
42:by acting as a
28:
23:
22:
15:
12:
11:
5:
4860:
4858:
4850:
4849:
4839:
4838:
4832:
4831:
4828:
4827:
4826:
4825:
4822:
4811:
4805:
4799:
4798:
4795:
4794:
4792:
4791:
4786:
4776:
4758:
4753:
4748:
4733:Sympatholytics
4730:
4721:
4702:
4697:
4695:Passion flower
4692:
4674:
4669:
4664:
4659:
4654:
4639:Gabapentinoids
4636:
4631:
4626:
4604:
4599:
4594:
4591:chlorpromazine
4575:Antipsychotics
4571:
4569:
4565:
4564:
4562:
4561:
4556:
4551:
4545:
4543:
4537:
4536:
4534:
4533:
4528:
4523:
4518:
4513:
4507:
4505:
4499:
4498:
4496:
4495:
4490:
4480:
4462:
4457:
4452:
4447:
4442:
4437:
4432:
4427:
4422:
4417:
4412:
4407:
4402:
4400:Dimenhydrinate
4397:
4392:
4386:
4384:
4374:
4369:Antihistamines
4365:
4364:
4362:
4361:
4356:
4351:
4344:Quinazolinones
4341:
4331:
4326:
4312:
4307:
4302:
4297:
4287:
4284:sodium bromide
4273:
4251:
4229:
4228:
4223:
4218:
4213:
4197:
4196:
4191:
4186:
4181:
4176:
4171:
4166:
4161:
4156:
4151:
4146:
4141:
4136:
4131:
4126:
4121:
4116:
4111:
4106:
4094:
4092:
4085:
4080:
4079:
4074:
4072:
4071:
4064:
4057:
4049:
4040:
4039:
4037:
4036:
4031:
4026:
4021:
4016:
4014:Passion flower
4011:
4001:
3996:
3995:
3994:
3989:
3984:
3979:
3974:
3960:
3955:
3950:
3945:
3944:
3943:
3938:
3933:
3923:
3922:
3921:
3910:
3908:
3904:
3903:
3901:
3900:
3895:
3890:
3885:
3880:
3874:
3872:
3863:
3857:
3856:
3854:
3853:
3848:
3843:
3837:
3835:
3829:
3828:
3826:
3825:
3820:
3815:
3810:
3804:
3802:
3796:
3795:
3792:
3791:
3789:
3788:
3782:
3780:
3776:
3775:
3773:
3772:
3771:
3770:
3764:
3759:
3749:
3748:
3747:
3741:
3739:Chlorpromazine
3730:
3728:
3726:Antipsychotics
3722:
3721:
3719:
3718:
3717:
3716:
3710:
3700:
3699:
3698:
3692:
3687:
3677:
3671:
3669:
3660:
3656:
3651:
3650:
3648:
3647:
3642:
3637:
3632:
3627:
3622:
3617:
3612:
3606:
3604:
3599:
3594:
3593:
3590:
3589:
3587:
3586:
3585:
3584:
3578:
3573:
3563:
3562:
3561:
3555:
3553:Chlorpromazine
3544:
3542:
3540:Antipsychotics
3536:
3535:
3533:
3532:
3531:
3530:
3524:
3514:
3513:
3512:
3506:
3501:
3491:
3490:
3489:
3484:
3479:
3468:
3466:
3460:
3459:
3457:
3456:
3451:
3446:
3441:
3436:
3431:
3426:
3421:
3416:
3414:Cyproheptadine
3411:
3405:
3403:
3401:Antihistamines
3394:
3390:
3385:
3384:
3382:
3381:
3376:
3371:
3366:
3361:
3358:sodium oxybate
3351:
3346:
3341:
3336:
3331:
3329:1,4-Butanediol
3325:
3323:
3319:
3314:
3313:
3310:
3309:
3307:
3306:
3305:
3304:
3302:Valerenic acid
3299:
3294:
3284:
3279:
3278:
3277:
3272:
3267:
3257:
3252:
3247:
3242:
3237:
3232:
3227:
3222:
3217:
3212:
3207:
3202:
3201:
3200:
3198:Sodium bromide
3195:
3190:
3179:
3174:
3168:
3166:
3162:
3161:
3159:
3158:
3153:
3148:
3143:
3138:
3133:
3128:
3123:
3118:
3113:
3107:
3105:
3103:Quinazolinones
3099:
3098:
3096:
3095:
3090:
3085:
3080:
3074:
3072:
3066:
3065:
3063:
3062:
3056:
3054:
3048:
3047:
3045:
3044:
3039:
3034:
3029:
3024:
3019:
3014:
3009:
3004:
2999:
2994:
2988:
2986:
2980:
2979:
2977:
2976:
2971:
2966:
2961:
2956:
2951:
2946:
2941:
2935:
2933:
2927:
2926:
2924:
2923:
2918:
2913:
2908:
2903:
2898:
2892:
2890:
2884:
2883:
2881:
2880:
2875:
2870:
2864:
2862:
2856:
2855:
2853:
2852:
2847:
2842:
2837:
2832:
2827:
2822:
2817:
2812:
2806:
2804:
2798:
2797:
2795:
2794:
2789:
2784:
2779:
2774:
2769:
2764:
2759:
2754:
2749:
2744:
2739:
2734:
2729:
2724:
2719:
2714:
2709:
2704:
2699:
2694:
2689:
2683:
2681:
2675:
2674:
2672:
2671:
2666:
2661:
2656:
2651:
2646:
2641:
2636:
2631:
2626:
2624:Propylbarbital
2621:
2616:
2611:
2606:
2601:
2596:
2591:
2586:
2581:
2576:
2571:
2566:
2561:
2556:
2551:
2546:
2540:
2538:
2532:
2531:
2529:
2528:
2523:
2521:Methylpentynol
2518:
2513:
2508:
2503:
2498:
2492:
2490:
2481:
2477:
2472:
2471:
2457:
2455:
2454:
2447:
2440:
2432:
2423:
2422:
2420:
2419:
2414:
2409:
2404:
2399:
2394:
2389:
2384:
2379:
2374:
2369:
2364:
2359:
2354:
2349:
2344:
2339:
2334:
2325:
2324:
2319:
2314:
2309:
2295:
2290:
2285:
2280:
2275:
2266:
2264:
2260:
2255:
2254:
2252:
2251:
2246:
2241:
2236:
2231:
2226:
2221:
2216:
2211:
2206:
2201:
2196:
2191:
2186:
2181:
2176:
2171:
2166:
2161:
2156:
2147:
2146:
2132:
2127:
2122:
2113:
2111:
2107:
2102:
2101:
2093:
2091:
2090:
2083:
2076:
2068:
2062:
2061:
2047:
2046:External links
2044:
2041:
2040:
2022:
1979:
1952:(5): 533–556.
1933:
1904:(4): 432–448.
1884:
1849:Brain Research
1835:
1786:
1743:
1692:
1648:
1594:
1545:
1518:(6): 629–633.
1502:
1470:
1444:
1418:
1369:
1315:
1269:
1207:
1169:
1122:
1078:
1060:
1042:
1024:
1006:
955:
928:(2): 259–268.
909:
880:(30): e21043.
857:
809:
782:(4): 530–532.
759:
708:
690:
641:
614:(2): 227–234.
598:
563:
509:
508:
506:
503:
499:antidepressant
456:
453:
420:
417:
415:
412:
400:
397:
350:
347:
338:
335:
295:
292:
290:
287:
286:
285:
281:
275:
271:
270:– selective OX
265:
253:
247:
243:
242:– selective OX
237:
233:
232:– selective OX
227:
223:
219:
213:
209:
205:
199:
195:
194:– selective OX
189:
185:
181:
175:
171:
170:– selective OX
163:
160:
159:
158:
154:
150:
144:
140:
132:
129:
128:
127:
123:
119:
113:
108:
104:
98:
94:
90:
82:
79:
77:
74:
60:
53:
27:Class of drugs
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4859:
4848:
4845:
4844:
4842:
4823:
4821:
4818:
4817:
4815:
4812:
4809:
4806:
4804:
4801:
4800:
4796:
4790:
4787:
4784:
4780:
4777:
4774:
4770:
4766:
4765:amitriptyline
4762:
4759:
4757:
4754:
4752:
4749:
4746:
4742:
4738:
4734:
4731:
4729:
4722:
4716:
4710:
4706:
4703:
4701:
4698:
4696:
4693:
4690:
4686:
4682:
4678:
4675:
4673:
4670:
4668:
4665:
4663:
4660:
4658:
4655:
4652:
4648:
4644:
4640:
4637:
4635:
4632:
4630:
4627:
4624:
4620:
4612:
4608:
4605:
4603:
4600:
4598:
4595:
4592:
4588:
4584:
4580:
4576:
4573:
4572:
4570:
4568:Miscellaneous
4566:
4560:
4557:
4555:
4552:
4550:
4547:
4546:
4544:
4542:
4538:
4532:
4529:
4527:
4524:
4522:
4519:
4517:
4514:
4512:
4509:
4508:
4506:
4504:
4500:
4494:
4491:
4488:
4484:
4481:
4478:
4474:
4470:
4469:amitriptyline
4466:
4463:
4461:
4458:
4456:
4453:
4451:
4448:
4446:
4443:
4441:
4438:
4436:
4433:
4431:
4430:Methapyrilene
4428:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4388:
4387:
4385:
4382:
4378:
4370:
4366:
4360:
4357:
4355:
4354:Sulfonmethane
4352:
4349:
4345:
4342:
4339:
4335:
4332:
4330:
4327:
4324:
4320:
4316:
4315:Neurosteroids
4313:
4311:
4308:
4306:
4305:Clomethiazole
4303:
4301:
4298:
4295:
4291:
4288:
4285:
4281:
4277:
4274:
4271:
4267:
4266:phenobarbital
4263:
4262:pentobarbital
4259:
4255:
4252:
4249:
4245:
4241:
4240:ethchlorvynol
4237:
4234:
4231:
4230:
4227:
4224:
4222:
4219:
4217:
4214:
4212:
4209:
4207:
4203:
4199:
4198:
4195:
4192:
4190:
4187:
4185:
4182:
4180:
4177:
4175:
4172:
4170:
4167:
4165:
4162:
4160:
4157:
4155:
4152:
4150:
4149:Flutoprazepam
4147:
4145:
4142:
4140:
4139:Flunitrazepam
4137:
4135:
4132:
4130:
4127:
4125:
4122:
4120:
4117:
4115:
4112:
4110:
4107:
4105:
4102:
4100:
4096:
4095:
4093:
4091:
4081:
4077:
4070:
4065:
4063:
4058:
4056:
4051:
4050:
4047:
4035:
4032:
4030:
4027:
4025:
4022:
4020:
4017:
4015:
4012:
4009:
4005:
4002:
4000:
3997:
3993:
3992:Methocarbamol
3990:
3988:
3985:
3983:
3982:Mephenoxalone
3980:
3978:
3975:
3973:
3972:Chlorphenesin
3970:
3969:
3968:
3964:
3961:
3959:
3956:
3954:
3951:
3949:
3946:
3942:
3941:Phenaglycodol
3939:
3937:
3934:
3932:
3929:
3928:
3927:
3924:
3920:
3917:
3916:
3915:
3912:
3911:
3909:
3905:
3899:
3896:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3876:
3875:
3873:
3871:
3858:
3852:
3849:
3847:
3844:
3842:
3839:
3838:
3836:
3834:
3830:
3824:
3821:
3819:
3816:
3814:
3811:
3809:
3806:
3805:
3803:
3801:
3797:
3787:
3784:
3783:
3781:
3777:
3768:
3765:
3763:
3760:
3758:
3755:
3754:
3753:
3750:
3745:
3742:
3740:
3737:
3736:
3735:
3732:
3731:
3729:
3727:
3723:
3714:
3711:
3709:
3706:
3705:
3704:
3701:
3696:
3693:
3691:
3688:
3686:
3685:Amitriptyline
3683:
3682:
3681:
3678:
3676:
3673:
3672:
3670:
3668:
3664:
3661:
3659:
3652:
3646:
3643:
3641:
3638:
3636:
3633:
3631:
3628:
3626:
3623:
3621:
3618:
3616:
3613:
3611:
3608:
3607:
3605:
3603:
3595:
3582:
3579:
3577:
3574:
3572:
3569:
3568:
3567:
3564:
3559:
3556:
3554:
3551:
3550:
3549:
3546:
3545:
3543:
3541:
3537:
3528:
3525:
3523:
3520:
3519:
3518:
3515:
3510:
3507:
3505:
3502:
3500:
3499:Amitriptyline
3497:
3496:
3495:
3492:
3488:
3485:
3483:
3480:
3478:
3475:
3474:
3473:
3470:
3469:
3467:
3465:
3461:
3455:
3452:
3450:
3447:
3445:
3442:
3440:
3437:
3435:
3434:Methapyrilene
3432:
3430:
3427:
3425:
3422:
3420:
3417:
3415:
3412:
3410:
3407:
3406:
3404:
3402:
3398:
3395:
3393:
3386:
3380:
3377:
3375:
3372:
3370:
3367:
3365:
3362:
3359:
3355:
3352:
3350:
3347:
3345:
3342:
3340:
3339:Aceburic acid
3337:
3335:
3332:
3330:
3327:
3326:
3324:
3322:
3315:
3303:
3300:
3298:
3295:
3293:
3292:Isovaleramide
3290:
3289:
3288:
3287:Sesquiterpene
3285:
3283:
3280:
3276:
3273:
3271:
3268:
3266:
3263:
3262:
3261:
3258:
3256:
3253:
3251:
3248:
3246:
3243:
3241:
3238:
3236:
3233:
3231:
3228:
3226:
3225:Clomethiazole
3223:
3221:
3218:
3216:
3213:
3211:
3208:
3206:
3203:
3199:
3196:
3194:
3191:
3189:
3186:
3185:
3183:
3180:
3178:
3175:
3173:
3170:
3169:
3167:
3163:
3157:
3154:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3127:
3124:
3122:
3119:
3117:
3114:
3112:
3109:
3108:
3106:
3104:
3100:
3094:
3091:
3089:
3088:Pyrithyldione
3086:
3084:
3081:
3079:
3076:
3075:
3073:
3071:
3067:
3061:
3058:
3057:
3055:
3053:
3049:
3043:
3040:
3038:
3035:
3033:
3030:
3028:
3025:
3023:
3020:
3018:
3015:
3013:
3010:
3008:
3005:
3003:
3000:
2998:
2995:
2993:
2990:
2989:
2987:
2985:
2981:
2975:
2972:
2970:
2967:
2965:
2962:
2960:
2957:
2955:
2952:
2950:
2947:
2945:
2942:
2940:
2937:
2936:
2934:
2932:
2928:
2922:
2919:
2917:
2914:
2912:
2909:
2907:
2904:
2902:
2899:
2897:
2894:
2893:
2891:
2889:
2885:
2879:
2876:
2874:
2871:
2869:
2866:
2865:
2863:
2861:
2857:
2851:
2848:
2846:
2843:
2841:
2840:Phenprobamate
2838:
2836:
2835:Methocarbamol
2833:
2831:
2828:
2826:
2825:Hexapropymate
2823:
2821:
2818:
2816:
2813:
2811:
2808:
2807:
2805:
2803:
2799:
2793:
2790:
2788:
2785:
2783:
2780:
2778:
2775:
2773:
2770:
2768:
2765:
2763:
2760:
2758:
2755:
2753:
2750:
2748:
2745:
2743:
2742:Flutoprazepam
2740:
2738:
2735:
2733:
2730:
2728:
2727:Flunitrazepam
2725:
2723:
2722:Flunitrazolam
2720:
2718:
2717:Flubromazolam
2715:
2713:
2710:
2708:
2705:
2703:
2700:
2698:
2695:
2693:
2690:
2688:
2685:
2684:
2682:
2680:
2676:
2670:
2667:
2665:
2662:
2660:
2657:
2655:
2652:
2650:
2647:
2645:
2642:
2640:
2637:
2635:
2632:
2630:
2627:
2625:
2622:
2620:
2619:Phenobarbital
2617:
2615:
2612:
2610:
2609:Pentobarbital
2607:
2605:
2604:Narcobarbital
2602:
2600:
2597:
2595:
2594:Mephobarbital
2592:
2590:
2587:
2585:
2582:
2580:
2577:
2575:
2574:Cyclobarbital
2572:
2570:
2567:
2565:
2562:
2560:
2557:
2555:
2552:
2550:
2547:
2545:
2542:
2541:
2539:
2537:
2533:
2527:
2524:
2522:
2519:
2517:
2516:Ethchlorvynol
2514:
2512:
2509:
2507:
2504:
2502:
2499:
2497:
2494:
2493:
2491:
2489:
2485:
2482:
2480:
2473:
2468:
2464:
2460:
2453:
2448:
2446:
2441:
2439:
2434:
2433:
2430:
2418:
2415:
2413:
2410:
2408:
2405:
2403:
2400:
2398:
2395:
2393:
2390:
2388:
2385:
2383:
2380:
2378:
2375:
2373:
2370:
2368:
2365:
2363:
2360:
2358:
2355:
2353:
2350:
2348:
2345:
2343:
2340:
2338:
2335:
2333:
2330:
2327:
2326:
2323:
2320:
2318:
2315:
2313:
2310:
2307:
2303:
2299:
2296:
2294:
2291:
2289:
2286:
2284:
2281:
2279:
2276:
2274:
2271:
2268:
2267:
2265:
2263:
2256:
2250:
2247:
2245:
2242:
2240:
2237:
2235:
2232:
2230:
2227:
2225:
2222:
2220:
2217:
2215:
2212:
2210:
2207:
2205:
2202:
2200:
2197:
2195:
2192:
2190:
2187:
2185:
2182:
2180:
2177:
2175:
2172:
2170:
2167:
2165:
2162:
2160:
2157:
2155:
2152:
2149:
2148:
2144:
2140:
2136:
2133:
2131:
2128:
2126:
2123:
2121:
2118:
2115:
2114:
2112:
2110:
2103:
2099:
2096:
2089:
2084:
2082:
2077:
2075:
2070:
2069:
2066:
2059:
2054:
2050:
2049:
2045:
2038:
2034:
2033:
2026:
2023:
2018:
2014:
2010:
2006:
2002:
1998:
1994:
1990:
1983:
1980:
1975:
1971:
1967:
1963:
1959:
1955:
1951:
1947:
1940:
1938:
1934:
1929:
1925:
1920:
1915:
1911:
1907:
1903:
1899:
1895:
1888:
1885:
1880:
1876:
1871:
1866:
1862:
1858:
1854:
1850:
1846:
1839:
1836:
1831:
1827:
1822:
1817:
1813:
1809:
1805:
1801:
1797:
1790:
1787:
1782:
1778:
1774:
1770:
1766:
1762:
1758:
1754:
1747:
1744:
1739:
1735:
1730:
1725:
1720:
1715:
1712:: 6035–6042.
1711:
1707:
1703:
1696:
1693:
1688:
1684:
1680:
1676:
1672:
1668:
1664:
1660:
1652:
1649:
1644:
1640:
1635:
1630:
1625:
1620:
1616:
1612:
1608:
1601:
1599:
1595:
1590:
1586:
1582:
1578:
1573:
1568:
1564:
1560:
1556:
1549:
1546:
1541:
1537:
1533:
1529:
1525:
1521:
1517:
1513:
1506:
1503:
1491:
1489:
1480:
1474:
1471:
1458:
1454:
1448:
1445:
1432:
1428:
1422:
1419:
1414:
1410:
1406:
1402:
1397:
1392:
1388:
1384:
1380:
1373:
1370:
1365:
1361:
1356:
1351:
1346:
1341:
1337:
1333:
1329:
1322:
1320:
1316:
1311:
1307:
1303:
1299:
1295:
1291:
1287:
1283:
1276:
1274:
1270:
1265:
1261:
1256:
1251:
1246:
1241:
1237:
1233:
1229:
1225:
1221:
1214:
1212:
1208:
1203:
1199:
1195:
1191:
1187:
1183:
1176:
1174:
1170:
1165:
1161:
1157:
1153:
1149:
1145:
1141:
1137:
1129:
1127:
1123:
1118:
1114:
1110:
1106:
1102:
1098:
1094:
1090:
1082:
1079:
1074:
1070:
1064:
1061:
1056:
1052:
1046:
1043:
1038:
1034:
1028:
1025:
1020:
1016:
1010:
1007:
1002:
998:
993:
988:
983:
978:
975:: 6035–6042.
974:
970:
966:
959:
956:
951:
947:
943:
939:
935:
931:
927:
923:
916:
914:
910:
905:
901:
896:
891:
887:
883:
879:
875:
871:
864:
862:
858:
853:
849:
845:
841:
837:
833:
829:
825:
818:
816:
814:
810:
805:
801:
797:
793:
789:
785:
781:
777:
770:
768:
766:
764:
760:
755:
751:
746:
741:
736:
731:
727:
723:
719:
712:
709:
704:
700:
694:
691:
686:
682:
678:
674:
670:
666:
662:
658:
650:
648:
646:
642:
637:
633:
629:
625:
621:
617:
613:
609:
602:
599:
594:
590:
586:
582:
578:
574:
567:
564:
559:
555:
550:
545:
540:
535:
531:
527:
526:
521:
514:
511:
504:
502:
500:
496:
492:
488:
484:
480:
477:
473:
469:
465:
461:
454:
452:
448:
444:
442:
438:
434:
430:
426:
418:
413:
411:
409:
405:
398:
396:
381:
379:
375:
371:
367:
363:
359:
355:
348:
346:
344:
336:
334:
332:
328:
323:
321:
320:sleep quality
317:
313:
309:
305:
301:
293:
288:
279:
276:
269:
266:
263:
259:
251:
248:
241:
238:
231:
228:
217:
214:
203:
200:
193:
190:
179:
176:
169:
166:
165:
161:
148:
145:
138:
135:
134:
130:
117:
114:
102:
99:
88:
85:
84:
80:
75:
73:
71:
67:
63:
56:
49:
45:
41:
37:
33:
19:
4789:Valnoctamide
4773:trimipramine
4615:dronabinol (
4607:Cannabinoids
4602:Benzoctamine
4511:Daridorexant
4493:Triprolidine
4477:trimipramine
4455:Propiomazine
4450:Promethazine
4415:Etodroxizine
4348:methaqualone
4338:glutethimide
4319:progesterone
4270:secobarbital
4254:Barbiturates
4232:
4200:
4164:Lormetazepam
4097:
4034:Valnoctamide
3936:Metaglycodol
3931:Fenpentadiol
3841:Daridorexant
3744:Thioridazine
3695:Trimipramine
3630:Medetomidine
3558:Thioridazine
3509:Trimipramine
3454:Propiomazine
3449:Promethazine
3255:Petrichloral
3240:Kavalactones
3172:Acetophenone
3141:Methaqualone
3136:Mecloqualone
3131:Mebroqualone
3121:Diproqualone
3116:Cloroqualone
3078:Glutethimide
2974:Progesterone
2964:Hydroxydione
2896:Acecarbromal
2810:Carisoprodol
2752:Lormetazepam
2737:Flutemazepam
2639:Secobarbital
2599:Methohexital
2589:Hexobarbital
2569:Butobarbital
2564:Butabarbital
2554:Aprobarbital
2544:Allobarbital
2536:Barbiturates
2372:JNJ-10397049
2347:Daridorexant
2329:Antagonists:
2328:
2269:
2189:Daridorexant
2151:Antagonists:
2150:
2116:
2030:
2025:
1992:
1988:
1982:
1949:
1945:
1901:
1897:
1887:
1852:
1848:
1838:
1803:
1799:
1789:
1756:
1752:
1746:
1709:
1705:
1695:
1665:(1): 38–41.
1662:
1658:
1651:
1617:(18): 6041.
1614:
1610:
1562:
1558:
1548:
1515:
1511:
1505:
1493:. Retrieved
1485:
1473:
1461:. Retrieved
1456:
1447:
1435:. Retrieved
1430:
1421:
1386:
1382:
1372:
1335:
1331:
1285:
1281:
1227:
1223:
1185:
1181:
1139:
1135:
1092:
1088:
1081:
1072:
1069:"Filorexant"
1063:
1054:
1051:"Almorexant"
1045:
1036:
1027:
1018:
1009:
972:
968:
958:
925:
921:
877:
873:
827:
823:
779:
775:
728:(18): 6041.
725:
721:
711:
702:
693:
663:(1): 38–41.
660:
656:
611:
607:
601:
576:
572:
566:
529:
523:
513:
458:
449:
445:
422:
414:Pharmacology
402:
382:
354:Side effects
352:
349:Side effects
340:
324:
297:
289:Medical uses
230:JNJ-10397049
162:Not marketed
87:Daridorexant
35:
31:
29:
4810:from market
4783:mirtazapine
4700:Scopolamine
4681:hydrocodone
4634:Fenadiazole
4597:Ashwagandha
4587:risperidone
4559:Tasimelteon
4531:Vornorexant
4521:Seltorexant
4516:Lemborexant
4487:mirtazapine
4445:Pimethixene
4435:Pheniramine
4420:Hydroxyzine
4390:Alimemazine
4329:Paraldehyde
4294:meprobamate
4258:amobarbital
4211:Eszopiclone
4174:Nimetazepam
4154:Haloxazolam
4124:Doxefazepam
4119:Clorazepate
4109:Cinolazepam
4019:Scopolamine
3963:Guaifenesin
3958:Fenadiazole
3914:Cannabidiol
3888:Mirogabalin
3846:Lemborexant
3823:Tasimelteon
3808:Agomelatine
3767:Risperidone
3713:Mirtazapine
3602:-Adrenergic
3581:Risperidone
3527:Mirtazapine
3477:Etoperidone
3444:Pheniramine
3429:Hydroxyzine
3250:Paraldehyde
3245:Loreclezole
3111:Afloqualone
3093:Piperidione
3083:Methyprylon
3012:Pazinaclone
2992:Eszopiclone
2954:Alphaxolone
2949:Alphadolone
2888:Monoureides
2830:Meprobamate
2767:Nitemazepam
2762:Nimetazepam
2707:Doxefazepam
2692:Cinolazepam
2664:Vinbarbital
2629:Proxibarbal
2614:Phenallymal
2549:Amobarbital
2501:Chloralodol
2397:Seltorexant
2377:Lemborexant
2312:Oveporexton
2209:Lemborexant
2032:NCT02669030
1389:: 489–496.
1073:AdisInsight
1055:AdisInsight
1037:AdisInsight
1019:AdisInsight
703:AdisInsight
483:Seltorexant
451:necessary.
441:vornorexant
437:seltorexant
433:lemborexant
318:(TST), and
147:Vornorexant
137:Seltorexant
101:Lemborexant
4741:guanfacine
4709:tryptophan
4672:Niaprazine
4647:pregabalin
4643:gabapentin
4583:olanzapine
4579:quetiapine
4526:Suvorexant
4460:Pyrilamine
4410:Doxylamine
4395:Captodiame
4323:zuranolone
4290:Carbamates
4179:Nitrazepam
4159:Loprazolam
4144:Flurazepam
4114:Climazolam
4104:Brotizolam
3987:Metaxalone
3977:Mephenesin
3898:Pregabalin
3878:Gabapentin
3851:Suvorexant
3786:Niaprazine
3762:Quetiapine
3757:Olanzapine
3640:Tizanidine
3635:Romifidine
3625:Lofexidine
3615:Detomidine
3576:Quetiapine
3571:Olanzapine
3482:Nefazodone
3424:Doxylamine
3409:Captodiame
3220:Chloralose
3184:compounds
3126:Etaqualone
3022:Suproclone
3002:Lirequinil
2969:Minaxolone
2959:Eltanolone
2939:Acebrochol
2906:Bromisoval
2873:Metomidate
2860:Imidazoles
2820:Ethinamate
2815:Emylcamate
2802:Carbamates
2777:Nitrazolam
2772:Nitrazepam
2747:Loprazolam
2732:Flurazepam
2702:Clonazolam
2697:Climazolam
2687:Brotizolam
2669:Vinylbital
2654:Thiopental
2412:TCS-OX2-29
2402:Suvorexant
2362:Filorexant
2342:Almorexant
2337:ACT-462206
2332:ACT-335827
2234:Suvorexant
2199:Filorexant
2164:Almorexant
2159:ACT-462206
2154:ACT-335827
2098:modulators
1855:: 146085.
1437:30 January
1142:: 101573.
528:(Review).
505:References
460:Filorexant
429:suvorexant
404:Narcolepsy
358:somnolence
284:antagonist
278:TCS-OX2-29
274:antagonist
246:antagonist
236:antagonist
216:GSK-649868
202:Filorexant
198:antagonist
178:Almorexant
174:antagonist
168:ACT-335827
116:Suvorexant
4820:Phase III
4808:Withdrawn
4756:Trazodone
4737:clonidine
4685:oxycodone
4629:Chamomile
4554:Ramelteon
4549:Melatonin
4425:Meclizine
4226:Zopiclone
4194:Triazolam
4189:Temazepam
4169:Midazolam
4129:Estazolam
4024:Trazodone
3965:-related
3818:Ramelteon
3813:Melatonin
3800:Melatonin
3708:Mianserin
3675:Trazodone
3610:Clonidine
3522:Mianserin
3487:Trazodone
3439:Perlapine
3282:Triclofos
3235:Gaboxadol
3042:Zopiclone
3027:Suriclone
3017:Saripidem
3007:Necopidem
2921:Ectylurea
2916:Carbromal
2878:Propoxate
2868:Etomidate
2845:Procymate
2792:Triazolam
2787:Temazepam
2757:Midazolam
2712:Estazolam
2649:Thiamylal
2584:Heptabarb
2463:sedatives
2459:Hypnotics
2317:SB-668875
2278:ALKS-2680
2270:Agonists:
2229:SB-408124
2224:SB-334867
2219:RTIOX-276
2117:Agonists:
1974:248119793
1781:221572078
1687:255944492
1611:Molecules
1589:0161-8105
1581:1550-9109
1540:221511561
1413:237589779
1310:219620600
1288:: 68–74.
1164:244689706
950:245076331
852:221572078
804:248494625
722:Molecules
685:255944492
532:: 17–38.
378:dry mouth
268:SB-408124
262:anorectic
250:SB-334867
240:RTIOX-276
4841:Category
4751:Theanine
4745:prazosin
4689:morphine
4662:Lavender
4651:phenibut
4623:nabilone
4611:cannabis
4377:receptor
4359:Valerian
4276:Bromides
4236:Alcohols
4221:Zolpidem
4216:Zaleplon
4184:Quazepam
4134:Etizolam
4088:receptor
4008:morphine
3999:Midaflur
3919:Cannabis
3893:Phenibut
3645:Xylazine
3374:Phenibut
3344:Baclofen
3270:Tetronal
3205:Centalun
3060:Propofol
3037:Zolpidem
3032:Zaleplon
2997:Indiplon
2911:Capuride
2850:Tybamate
2782:Quazepam
2644:Talbutal
2559:Barbital
2488:Alcohols
2407:TCS-1102
2239:TCS-1102
2169:AZD-4041
2017:56482209
2009:30576764
1966:35043499
1928:31782044
1879:30590027
1830:30092886
1773:32901578
1738:26648692
1679:36649550
1643:36144776
1532:32890017
1457:DailyMed
1431:DailyMed
1405:34560134
1364:34121443
1355:10394202
1302:32531478
1264:26317363
1224:PLOS ONE
1202:28365447
1156:34902823
1117:24935644
1109:11298806
1001:26648692
942:34881812
904:32791676
874:Medicine
844:32901578
796:35491942
754:36144776
677:36649550
636:42562238
628:21170610
593:18673167
558:36713640
468:migraine
455:Research
366:headache
343:delirium
337:Delirium
310:(WASO),
294:Insomnia
258:sedative
81:Marketed
76:Examples
70:insomnia
68:such as
4781:(e.g.,
4769:doxepin
4763:(e.g.,
4735:(e.g.,
4679:(e.g.,
4677:Opioids
4641:(e.g.,
4609:(e.g.,
4577:(e.g.,
4485:(e.g.,
4473:doxepin
4467:(e.g.,
4346:(e.g.,
4336:(e.g.,
4317:(e.g.,
4292:(e.g.,
4278:(e.g.,
4256:(e.g.,
4248:ethanol
4238:(e.g.,
4233:Others:
4206:Z-drugs
4006:(e.g.,
4004:Opioids
3953:Evoxine
3690:Doxepin
3504:Doxepin
3379:Tolibut
3275:Trional
3182:Bromide
3052:Phenols
2634:Reposal
2392:MK-8133
2387:MK-3697
2382:MK-1064
2184:CVN-766
2179:CR-5542
1995:: 1–7.
1919:7142186
1870:6591110
1821:6086961
1729:4651361
1634:9502995
1495:3 March
1463:17 June
1255:4552781
1232:Bibcode
1188:: 1–7.
992:4651361
895:7386982
745:9502995
549:9879039
495:adjunct
491:phase 4
487:phase 3
476:phase 2
374:fatigue
306:(LPS),
4803:WHO-EM
3907:Others
3833:Orexin
3779:Others
3769:, etc.
3746:, etc.
3715:, etc.
3697:, etc.
3583:, etc.
3560:, etc.
3529:, etc.
3511:, etc.
3165:Others
3156:SL-164
2298:Orexin
2288:E-2086
2273:AEX-19
2135:Orexin
2130:AEX-24
2125:AEX-19
2015:
2007:
1972:
1964:
1926:
1916:
1877:
1867:
1828:
1818:
1779:
1771:
1736:
1726:
1685:
1677:
1641:
1631:
1587:
1579:
1538:
1530:
1411:
1403:
1362:
1352:
1308:
1300:
1262:
1252:
1200:
1162:
1154:
1115:
1107:
999:
989:
948:
940:
902:
892:
850:
842:
802:
794:
752:
742:
683:
675:
634:
626:
591:
556:
546:
470:, and
393:
389:
385:
376:, and
322:(SQ).
314:(SE),
222:and OX
208:and OX
184:and OX
153:and OX
122:and OX
107:and OX
93:and OX
40:orexin
4714:5-HTP
4029:UMB68
3349:GABOB
2120:AEX-5
2013:S2CID
1970:S2CID
1777:S2CID
1683:S2CID
1577:eISSN
1559:Sleep
1536:S2CID
1490:(FDA)
1486:U.S.
1482:(PDF)
1409:S2CID
1306:S2CID
1160:S2CID
1113:S2CID
946:S2CID
848:S2CID
800:S2CID
681:S2CID
632:S2CID
112:hours
34:, or
4657:Hops
4310:Kava
4084:GABA
3869:VDCC
3655:5-HT
3318:GABA
2496:2M2B
2476:GABA
2467:N05C
2352:EMPA
2005:PMID
1962:PMID
1924:PMID
1875:PMID
1853:1731
1826:PMID
1769:PMID
1734:PMID
1675:PMID
1639:PMID
1585:ISSN
1528:PMID
1497:2022
1465:2021
1439:2020
1401:PMID
1360:PMID
1298:PMID
1260:PMID
1198:PMID
1152:PMID
1105:PMID
997:PMID
938:PMID
900:PMID
840:PMID
792:PMID
750:PMID
673:PMID
624:PMID
589:PMID
554:PMID
423:The
395:mg.
260:and
192:EMPA
57:and
4726:GHB
4617:THC
3369:GVL
3364:GBL
3354:GHB
1997:doi
1954:doi
1950:291
1914:PMC
1906:doi
1865:PMC
1857:doi
1816:PMC
1808:doi
1761:doi
1724:PMC
1714:doi
1667:doi
1629:PMC
1619:doi
1567:doi
1520:doi
1391:doi
1387:131
1350:PMC
1340:doi
1290:doi
1286:128
1250:PMC
1240:doi
1190:doi
1144:doi
1097:doi
987:PMC
977:doi
930:doi
890:PMC
882:doi
832:doi
784:doi
740:PMC
730:doi
665:doi
616:doi
581:doi
544:PMC
534:doi
497:to
474:in
30:An
4843::
4816::
4771:,
4767:,
4743:,
4739:,
4711:,
4687:,
4683:,
4649:,
4645:,
4621:,
4613:,
4589:,
4585:,
4581:,
4475:,
4471:,
4321:,
4282:,
4268:,
4264:,
4260:,
4246:,
4242:,
3657:2A
2304:,
2259:OX
2141:,
2106:OX
2011:.
2003:.
1993:92
1991:.
1968:.
1960:.
1948:.
1936:^
1922:.
1912:.
1902:36
1900:.
1896:.
1873:.
1863:.
1851:.
1847:.
1824:.
1814:.
1804:14
1802:.
1798:.
1775:.
1767:.
1757:16
1755:.
1732:.
1722:.
1708:.
1704:.
1681:.
1673:.
1663:29
1661:.
1637:.
1627:.
1615:27
1613:.
1609:.
1597:^
1583:.
1575:.
1563:43
1561:.
1557:.
1534:.
1526:.
1516:26
1514:.
1484:.
1455:.
1429:.
1407:.
1399:.
1385:.
1381:.
1358:.
1348:.
1336:27
1334:.
1330:.
1318:^
1304:.
1296:.
1284:.
1272:^
1258:.
1248:.
1238:.
1228:10
1226:.
1222:.
1210:^
1196:.
1186:35
1184:.
1172:^
1158:.
1150:.
1140:61
1138:.
1125:^
1111:.
1103:.
1093:13
1091:.
1071:.
1053:.
1035:.
1017:.
995:.
985:.
971:.
967:.
944:.
936:.
926:22
924:.
912:^
898:.
888:.
878:99
876:.
872:.
860:^
846:.
838:.
828:16
826:.
812:^
798:.
790:.
780:30
778:.
762:^
748:.
738:.
726:27
724:.
720:.
701:.
679:.
671:.
661:29
659:.
644:^
630:.
622:.
612:11
610:.
587:.
575:.
552:.
542:.
530:15
522:.
481:.
466:,
443:.
380:.
372:,
368:,
364:,
360:,
345:.
333:.
72:.
59:OX
52:OX
50:,
4785:)
4775:)
4747:)
4728:)
4720:)
4707:(
4691:)
4653:)
4625:)
4619:)
4593:)
4489:)
4479:)
4383:)
4375:1
4373:H
4371:(
4350:)
4340:)
4325:)
4296:)
4286:)
4272:)
4250:)
4208::
4204:/
4101::
4086:A
4068:e
4061:t
4054:v
4010:)
3866:δ
3864:2
3862:α
3600:2
3598:α
3391:1
3389:H
3360:)
3356:(
3320:B
2478:A
2469:)
2465:(
2461:/
2451:e
2444:t
2437:v
2308:)
2306:B
2302:A
2300:(
2261:2
2145:)
2143:B
2139:A
2137:(
2108:1
2087:e
2080:t
2073:v
2019:.
1999::
1976:.
1956::
1930:.
1908::
1881:.
1859::
1832:.
1810::
1783:.
1763::
1740:.
1716::
1710:9
1689:.
1669::
1645:.
1621::
1591:.
1569::
1542:.
1522::
1499:.
1467:.
1441:.
1415:.
1393::
1366:.
1342::
1312:.
1292::
1266:.
1242::
1234::
1204:.
1192::
1166:.
1146::
1119:.
1099::
1003:.
979::
973:9
952:.
932::
906:.
884::
854:.
834::
806:.
786::
756:.
732::
687:.
667::
638:.
618::
595:.
583::
577:8
560:.
536::
282:2
272:1
254:1
244:1
234:2
224:2
220:1
210:2
206:1
196:2
186:2
182:1
172:1
155:2
151:1
141:2
124:2
120:1
109:2
105:1
95:2
91:1
61:2
54:1
20:)
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