255:
232:
129:
154:
506:
261:
160:
1324:. Homozygous and heterozygous c.144delC mutation in the AURKC gene was found with an allelic frequency of 2.14% in Moroccan men with unexplained spermatogenic failure. The heterozygous state had a frequency of 1% in normospermic fertile men. Although c.144delC represents 85.5% of mutant alleles, the
2005:
Ben
Khelifa M, Coutton C, Blum MG, Abada F, Harbuz R, Zouari R, Guichet A, May-Panloup P, Mitchell V, Rollet J, Triki C, Merdassi G, Vialard F, Koscinski I, Viville S, Keskes L, Soulie JP, Rives N, Dorphin B, Lestrade F, Hesters L, Poirot C, Benzacken B, Jouk PS, Satre V, Hennebicq S, Arnoult C,
2237:
Clark AG, Glanowski S, Nielsen R, Thomas PD, Kejariwal A, Todd MA, Tanenbaum DM, Civello D, Lu F, Murphy B, Ferriera S, Wang G, Zheng X, White TJ, Sninsky JJ, Adams MD, Cargill M (December 2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios".
2318:
Sasai K, Katayama H, Stenoien DL, Fujii S, Honda R, Kimura M, Okano Y, Tatsuka M, Suzuki F, Nigg EA, Earnshaw WC, Brinkley WR, Sen S (December 2004). "Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells".
1518:
Sasai K, Katayama H, Stenoien DL, Fujii S, Honda R, Kimura M, Okano Y, Tatsuka M, Suzuki F, Nigg EA, Earnshaw WC, Brinkley WR, Sen S (December 2004). "Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells".
1868:
Fujii S, Srivastava V, Hegde A, Kondo Y, Shen L, Hoshino K, Gonzalez Y, Wang J, Sasai K, Ma X, Katayama H, Estecio MR, Hamilton SR, Wistuba I, Issa JP, Sen S (September 2015). "Regulation of AURKC expression by CpG island methylation in human cancer cells".
2172:
Tseng TC, Chen SH, Hsu YP, Tang TK (October 1998). "Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators".
1264:
results from independent and simultaneous inhibition of Aurora B and Aurora C. Slattery et al. found that they have overlapping functions and that Aurora C was able to rescue Aurora B-deficient mitotic cells from aneuploidy.
1462:
Bernard M, Sanseau P, Henry C, Couturier A, Prigent C (November 1998). "Cloning of STK13, a third human protein kinase related to
Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter".
1285:
are the most studied modes of regulating AURKC regulation. Although all of the Aurora kinases are overexpressed in many cancer cell lines, only Aurora A and C possess oncogenic activity, producing
2443:
Dutertre S, Hamard-Péron E, Cremet JY, Thomas Y, Prigent C (December 2005). "The absence of p53 aggravates polyploidy and centrosome number abnormality induced by Aurora-C overexpression".
1229:
and protein concentrations peaking during the G2/M phase. Aurora C levels, however, peak after those of Aurora B later in the M phase. While Aurora A and B are expressed in mitotic
268:
167:
2406:
Yan X, Cao L, Li Q, Wu Y, Zhang H, Saiyin H, Liu X, Zhang X, Shi Q, Yu L (June 2005). "Aurora C is directly associated with
Survivin and required for cytokinesis".
2480:
Dieterich K, Soto Rifo R, Faure AK, Hennebicq S, Ben Amar B, Zahi M, Perrin J, Martinez D, Sèle B, Jouk PS, Ohlmann T, Rousseaux S, Lunardi J, Ray PF (May 2007).
2377:
Chen HL, Tang CJ, Chen CY, Tang TK (2005). "Overexpression of an Aurora-C kinase-deficient mutant disrupts the Aurora-B/INCENP complex and induces polyploidy".
1162:. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing
1833:
Pereira HS, Soares Lima SC, de Faria PS, Cardoso LC, Seuanez HN (January 2018). "AURKC promoter regions are differentially methylated in Wilms' tumor".
829:
90:
2006:
Lunardi J, Ray PF (November 2012). "Identification of a new recurrent aurora kinase C mutation in both
European and African men with macrozoospermia".
810:
1735:
Tsou JH, Chang KC, Chang-Liao PY, Yang ST, Lee CT, Chen YP, Lee YC, Lin BW, Lee JC, Shen MR, Chuang CK, Chang WC, Wang JM, Hung LY (October 2011).
2090:
Fernández-Miranda G, Trakala M, Martín J, Escobar B, González A, Ghyselinck NB, Ortega S, Cañamero M, Pérez de Castro I, Malumbres M (July 2011).
2557:
1444:
1426:
2348:
Yan X, Wu Y, Li Q, Cao L, Liu X, Saiyin H, Yu L (March 2005). "Cloning and characterization of a novel human Aurora C splicing variant".
254:
2529:
1061:
231:
1068:
1501:
1356:
to the conserved IN box domain, but Aurora B preferentially binds INCENP. The chromosomal passenger complex (CPC), essential for
1413:
1392:
1214:
contain only two, mammals have three Aurora kinases with 67-76% homology that are structurally similar and localize similarly.
1151:
153:
128:
1915:
Lin BW, Wang YC, Chang-Liao PY, Lin YJ, Yang ST, Tsou JH, Chang KC, Liu YW, Tseng JT, Lee CT, Lee JC, Hung LY (March 2014).
1409:
1368:(also known as dasra). Co-expression of Aurora B and C in vivo interferes with INCENP binding, localization, and stability.
2535:
1388:
70:
2285:"Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C"
2204:"Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3"
1178:. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction.
1282:
1253:
2135:
Katayama H, Brinkley WR, Sen S (December 2003). "The Aurora kinases: role in cell transformation and tumorigenesis".
1297:
to turn on the SAC, Aurora B protein stability and activity decreased. This then prevented activation of SAC protein
267:
166:
2283:
Li X, Sakashita G, Matsuzaki H, Sugimoto K, Kimura K, Hanaoka F, Taniguchi H, Furukawa K, Urano T (November 2004).
1333:
260:
159:
1191:
874:
78:
1328:
p.Y248* (13% of all mutant alleles) is present in both
European and African men and can lead to infertility.
1917:"Overexpression of Aurora-C interferes with the spindle checkpoint by promoting the degradation of Aurora-B"
855:
2092:"Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development"
1554:
Crosio C, Fimia GM, Loury R, Kimura M, Okano Y, Zhou H, Sen S, Allis CD, Sassone-Corsi P (February 2002).
1357:
142:
1273:
Expression is typically limited to meiotic cells, but overexpression occurs in some cancer cell lines.
2247:
1619:
1329:
1179:
57:
2482:"Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility"
2541:
1040:
1036:
1011:
1007:
977:
973:
948:
944:
1606:
Khan J, Ezan F, Crémet JY, Fautrel A, Gilot D, Lambert M, Benaud C, Troadec MB, Prigent C (2011).
2509:
2468:
2431:
2271:
2160:
1894:
1766:
102:
1737:"Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells"
1221:
to cytokinesis. It is expressed about an order of magnitude less than Aurora B in diploid human
1044:
1015:
981:
952:
1964:
Eloualid A, Rouba H, Rhaissi H, Barakat A, Louanjli N, Bashamboo A, McElreavey K (April 2014).
1784:
Nna E, Madukwe J, Egbujo E, Obiorah C, Okolie C, Echejoh G, Yahaya A, Adisa J, Uzoma I (2013).
1556:"Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases"
2501:
2460:
2423:
2394:
2365:
2336:
2306:
2263:
2225:
2190:
2152:
2113:
2072:
2023:
1987:
1946:
1886:
1850:
1815:
1758:
1688:
1647:
1608:"Overexpression of active Aurora-C kinase results in cell transformation and tumour formation"
1585:
1536:
1480:
1325:
1171:
505:
50:
2493:
2452:
2415:
2386:
2357:
2328:
2296:
2255:
2215:
2182:
2144:
2103:
2062:
2054:
2015:
1977:
1936:
1928:
1878:
1842:
1805:
1797:
1748:
1678:
1637:
1627:
1575:
1567:
1528:
1472:
1317:
347:
278:
222:
177:
98:
1302:
1257:
1234:
322:
2251:
1623:
2067:
2042:
1941:
1916:
1810:
1785:
1642:
1607:
2043:"The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis"
1786:"Gene expression of Aurora kinases in prostate cancer and nodular hyperplasia tissues"
1580:
1555:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
658:
653:
648:
643:
638:
633:
628:
623:
618:
613:
608:
603:
587:
582:
577:
572:
567:
562:
557:
552:
547:
2551:
2419:
1982:
1965:
1286:
1147:
534:
2513:
2472:
2435:
2164:
1770:
82:
2275:
1898:
1336:
analyses are the most common genetic tests offered to infertile men, but AURKC and
1230:
1217:
Aurora C localizes to the centrosome and then to the midzone of mitotic cells from
340:
119:
1571:
1632:
106:
1966:"Prevalence of the Aurora kinase C c.144delC mutation in infertile Moroccan men"
1449:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1431:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1321:
1249:
1245:
1199:
1163:
2361:
423:
17:
2390:
2148:
1882:
1353:
1306:
1294:
1261:
1222:
1211:
1207:
1167:
239:
136:
86:
2259:
2220:
2203:
2186:
2019:
1706:
1278:
1238:
774:
483:
361:
306:
293:
205:
192:
94:
2505:
2481:
2464:
2427:
2398:
2369:
2340:
2310:
2301:
2284:
2267:
2229:
2156:
2117:
2076:
2027:
1991:
1950:
1890:
1854:
1819:
1762:
1692:
1651:
1589:
1540:
1476:
61:, AIE2, AIK3, ARK3, AurC, SPGF5, STK13, aurora-C, HEL-S-90, aurora kinase C
2194:
1932:
1484:
1108:
1103:
2456:
1683:
1667:"Aurora-C kinase supports mitotic progression in the absence of Aurora-B"
1666:
1365:
1361:
1293:
when overexpressed. When cells overexpressing Aurora C were treated with
1218:
1195:
1159:
1155:
1092:
919:
900:
2108:
2091:
1337:
1290:
1175:
886:
841:
1801:
1753:
1736:
2332:
1532:
1349:
1128:
1076:
796:
2058:
2497:
1340:
defects are the leading cause of infertility in North
African men.
1310:
1298:
1203:
1202:
indicate association with mitotic and meiotic structure. Although
1846:
759:
755:
2041:
Carmena M, Wheelock M, Funabiki H, Earnshaw WC (December 2012).
1665:
Slattery SD, Mancini MA, Brinkley BR, Hall RM (September 2009).
1274:
1226:
1135:
74:
514:
1316:
Inactivating mutations of Aurora C have been shown to cause
1360:, contains the four subunits: the Aurora kinase, INCENP,
330:
2202:
Kimura M, Matsuda Y, Yoshioka T, Okano Y (March 1999).
495:
1320:
characterized by macrocephalic and multiflagellular
1248:
maturation, destabilization of improper kinetochore-
2350:
1233:, Aurora C is more often expressed during meiosis (
1146:This gene encodes a member of the highly conserved
1029:
1000:
966:
937:
1405:
1403:
1401:
1384:
1382:
1380:
730:attachment of spindle microtubules to kinetochore
578:protein serine/threonine/tyrosine kinase activity
277:
176:
29:Protein-coding gene in the species Homo sapiens
1410:GRCm38: Ensembl release 89: ENSMUSG00000070837
8:
1389:GRCh38: Ensembl release 89: ENSG00000105146
770:
530:
318:
217:
114:
2300:
2219:
2107:
2066:
1981:
1940:
1809:
1752:
1682:
1641:
1631:
1579:
1182:results in multiple transcript variants.
1496:
1494:
1194:of Aurora kinases in mitotic cells from
573:protein serine/threonine kinase activity
1513:
1511:
1376:
2047:Nature Reviews. Molecular Cell Biology
1910:
1908:
1601:
1599:
1348:Both Aurora B and C interact with the
31:
282:
243:
238:
181:
140:
135:
7:
1502:"Entrez Gene: AURKC aurora kinase C"
2289:The Journal of Biological Chemistry
2208:The Journal of Biological Chemistry
1206:contain only one Aurora kinase and
2321:Cell Motility and the Cytoskeleton
1521:Cell Motility and the Cytoskeleton
1125:Serine/threonine-protein kinase 13
1026:
997:
963:
934:
910:
891:
865:
846:
820:
801:
695:positive regulation of cytokinesis
500:
418:
356:
335:
25:
1716:. Cell Signaling Technology. 2008
1190:Temporal expression patterns and
1131:that in humans is encoded by the
2420:10.1111/j.1365-2443.2005.00863.x
1983:10.1016/j.fertnstert.2013.12.040
1152:serine/threonine protein kinases
680:mitotic spindle midzone assembly
504:
266:
259:
253:
230:
165:
158:
152:
127:
1790:Medical Principles and Practice
1260:organization, and cytokinesis.
1560:Molecular and Cellular Biology
644:chromosome, centromeric region
563:histone serine kinase activity
515:More reference expression data
484:More reference expression data
1:
2379:Journal of Biomedical Science
2137:Cancer and Metastasis Reviews
1572:10.1128/MCB.22.3.874-885.2002
251:
150:
2558:Genes on human chromosome 19
1633:10.1371/journal.pone.0026512
740:mitotic spindle organization
624:chromosome passenger complex
1254:spindle assembly checkpoint
400:stromal cell of endometrium
2574:
2540:gene details page in the
2362:10.1016/j.bbrc.2004.12.168
1334:Y chromosome microdeletion
1244:Aurora B kinase regulates
2391:10.1007/s11373-005-0980-0
1883:10.1007/s13277-015-3553-5
1445:"Mouse PubMed Reference:"
1427:"Human PubMed Reference:"
1107:
1102:
1098:
1091:
1075:
1056:
1033:
1004:
993:
970:
941:
930:
917:
913:
898:
894:
885:
872:
868:
853:
849:
840:
827:
823:
808:
804:
795:
780:
773:
769:
753:
745:regulation of cytokinesis
533:
529:
512:
503:
494:
481:
430:
421:
368:
359:
329:
321:
317:
300:
287:
250:
229:
220:
216:
199:
186:
149:
126:
117:
113:
68:
65:
55:
48:
43:
39:
34:
1921:Cell Death & Disease
1741:The Journal of Pathology
1350:inner centromere protein
1192:subcellular localization
1154:with two other members,
1062:Chr 19: 57.23 – 57.24 Mb
715:spindle midzone assembly
458:male reproductive system
2260:10.1126/science.1088821
2221:10.1074/jbc.274.11.7334
2187:10.1089/dna.1998.17.823
2149:10.1023/A:1023789416385
1970:Fertility and Sterility
1835:Frontiers in Bioscience
705:protein phosphorylation
614:spindle pole centrosome
553:protein kinase activity
2302:10.1074/jbc.M403029200
1477:10.1006/geno.1998.5522
1358:chromosome segregation
1283:CpG island methylation
2020:10.1093/humrep/des296
1933:10.1038/cddis.2014.37
1269:Clinical significance
143:Chromosome 19 (human)
2534:genome location and
2457:10.4161/cc.4.12.2172
2175:DNA and Cell Biology
1684:10.4161/cc.8.18.9591
1330:Klinefelter syndrome
1287:multinucleated cells
1180:Alternative splicing
685:histone modification
654:condensed chromosome
548:transferase activity
245:Chromosome 7 (mouse)
2542:UCSC Genome Browser
2252:2003Sci...302.1960C
1624:2011PLoSO...626512K
634:spindle microtubule
284:7 A1|7 4.06 cM
2109:10.1242/dev.066381
2008:Human Reproduction
1714:www.cellsignal.com
1352:(INCENP) from the
1318:infertility in men
1277:, a transcription
1069:Chr 7: 7 – 7.01 Mb
875:ENSMUSG00000070837
690:oocyte development
668:Biological process
597:Cellular component
558:nucleotide binding
541:Molecular function
1802:10.1159/000342679
1754:10.1002/path.2934
1707:"Aurora C Kinase"
1326:nonsense mutation
1252:attachments, and
1118:
1117:
1114:
1113:
1087:
1086:
1052:
1051:
1023:
1022:
989:
988:
960:
959:
926:
925:
907:
906:
881:
880:
862:
861:
836:
835:
817:
816:
765:
764:
525:
524:
521:
520:
490:
489:
477:
476:
415:
414:
313:
312:
212:
211:
107:AURKC - orthologs
16:(Redirected from
2565:
2517:
2476:
2439:
2402:
2373:
2344:
2333:10.1002/cm.20039
2314:
2304:
2295:(45): 47201–11.
2279:
2246:(5652): 1960–3.
2233:
2223:
2198:
2168:
2122:
2121:
2111:
2087:
2081:
2080:
2070:
2038:
2032:
2031:
2002:
1996:
1995:
1985:
1961:
1955:
1954:
1944:
1912:
1903:
1902:
1865:
1859:
1858:
1830:
1824:
1823:
1813:
1781:
1775:
1774:
1756:
1732:
1726:
1725:
1723:
1721:
1711:
1703:
1697:
1696:
1686:
1662:
1656:
1655:
1645:
1635:
1603:
1594:
1593:
1583:
1551:
1545:
1544:
1533:10.1002/cm.20039
1515:
1506:
1505:
1498:
1489:
1488:
1459:
1453:
1452:
1441:
1435:
1434:
1423:
1417:
1407:
1396:
1386:
1174:function during
1100:
1099:
1071:
1064:
1047:
1027:
1018:
998:
994:RefSeq (protein)
984:
964:
955:
935:
911:
892:
866:
847:
821:
802:
771:
531:
517:
508:
501:
486:
434:secondary oocyte
426:
424:Top expressed in
419:
376:secondary oocyte
364:
362:Top expressed in
357:
336:
319:
309:
296:
285:
270:
263:
257:
246:
234:
218:
208:
195:
184:
169:
162:
156:
145:
131:
115:
109:
60:
53:
32:
21:
2573:
2572:
2568:
2567:
2566:
2564:
2563:
2562:
2548:
2547:
2525:
2520:
2486:Nature Genetics
2479:
2442:
2405:
2376:
2347:
2317:
2282:
2236:
2214:(11): 7334–40.
2201:
2171:
2134:
2130:
2128:Further reading
2125:
2102:(13): 2661–72.
2089:
2088:
2084:
2059:10.1038/nrm3474
2053:(12): 789–803.
2040:
2039:
2035:
2014:(11): 3337–46.
2004:
2003:
1999:
1963:
1962:
1958:
1914:
1913:
1906:
1877:(10): 8147–58.
1867:
1866:
1862:
1832:
1831:
1827:
1783:
1782:
1778:
1734:
1733:
1729:
1719:
1717:
1709:
1705:
1704:
1700:
1677:(18): 2984–94.
1664:
1663:
1659:
1605:
1604:
1597:
1553:
1552:
1548:
1517:
1516:
1509:
1500:
1499:
1492:
1461:
1460:
1456:
1443:
1442:
1438:
1425:
1424:
1420:
1408:
1399:
1387:
1378:
1374:
1346:
1303:phosphorylation
1271:
1258:central spindle
1235:spermatogenesis
1188:
1166:in relation to
1144:
1121:Aurora kinase C
1109:View/Edit Mouse
1104:View/Edit Human
1067:
1060:
1057:Location (UCSC)
1043:
1039:
1035:
1014:
1010:
1006:
980:
976:
972:
951:
947:
943:
856:ENSG00000105146
749:
720:spermatogenesis
675:phosphorylation
663:
639:spindle midzone
592:
588:protein binding
568:kinase activity
513:
482:
473:
468:
464:
460:
456:
454:male human body
452:
448:
444:
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436:
422:
411:
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398:
394:
390:
386:
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291:
283:
273:
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271:
264:
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221:Gene location (
203:
190:
182:
172:
171:
170:
163:
141:
118:Gene location (
69:
56:
49:
30:
23:
22:
18:Aurora C kinase
15:
12:
11:
5:
2571:
2569:
2561:
2560:
2550:
2549:
2546:
2545:
2524:
2523:External links
2521:
2519:
2518:
2498:10.1038/ng2027
2477:
2451:(12): 1783–7.
2440:
2408:Genes to Cells
2403:
2385:(2): 297–310.
2374:
2345:
2315:
2280:
2234:
2199:
2181:(10): 823–33.
2169:
2131:
2129:
2126:
2124:
2123:
2082:
2033:
1997:
1976:(4): 1086–90.
1956:
1904:
1871:Tumour Biology
1860:
1841:(1): 143–154.
1825:
1776:
1727:
1698:
1657:
1618:(10): e26512.
1595:
1546:
1507:
1490:
1454:
1436:
1418:
1397:
1375:
1373:
1370:
1345:
1342:
1270:
1267:
1187:
1184:
1143:
1140:
1116:
1115:
1112:
1111:
1106:
1096:
1095:
1089:
1088:
1085:
1084:
1082:
1080:
1073:
1072:
1065:
1058:
1054:
1053:
1050:
1049:
1031:
1030:
1024:
1021:
1020:
1002:
1001:
995:
991:
990:
987:
986:
968:
967:
961:
958:
957:
939:
938:
932:
928:
927:
924:
923:
915:
914:
908:
905:
904:
896:
895:
889:
883:
882:
879:
878:
870:
869:
863:
860:
859:
851:
850:
844:
838:
837:
834:
833:
825:
824:
818:
815:
814:
806:
805:
799:
793:
792:
787:
782:
778:
777:
767:
766:
763:
762:
751:
750:
748:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
692:
687:
682:
677:
671:
669:
665:
664:
662:
661:
656:
651:
646:
641:
636:
631:
626:
621:
616:
611:
606:
600:
598:
594:
593:
591:
590:
585:
580:
575:
570:
565:
560:
555:
550:
544:
542:
538:
537:
527:
526:
523:
522:
519:
518:
510:
509:
498:
492:
491:
488:
487:
479:
478:
475:
474:
472:
471:
467:
463:
459:
455:
451:
447:
443:
442:primary oocyte
439:
435:
431:
428:
427:
416:
413:
412:
410:
409:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
366:
365:
353:
352:
344:
333:
327:
326:
323:RNA expression
315:
314:
311:
310:
302:
298:
297:
289:
286:
281:
275:
274:
265:
258:
252:
248:
247:
242:
236:
235:
227:
226:
214:
213:
210:
209:
201:
197:
196:
188:
185:
180:
174:
173:
164:
157:
151:
147:
146:
139:
133:
132:
124:
123:
111:
110:
67:
63:
62:
54:
46:
45:
41:
40:
37:
36:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2570:
2559:
2556:
2555:
2553:
2543:
2539:
2538:
2533:
2532:
2527:
2526:
2522:
2515:
2511:
2507:
2503:
2499:
2495:
2491:
2487:
2483:
2478:
2474:
2470:
2466:
2462:
2458:
2454:
2450:
2446:
2441:
2437:
2433:
2429:
2425:
2421:
2417:
2414:(6): 617–26.
2413:
2409:
2404:
2400:
2396:
2392:
2388:
2384:
2380:
2375:
2371:
2367:
2363:
2359:
2356:(1): 353–61.
2355:
2351:
2346:
2342:
2338:
2334:
2330:
2327:(4): 249–63.
2326:
2322:
2316:
2312:
2308:
2303:
2298:
2294:
2290:
2286:
2281:
2277:
2273:
2269:
2265:
2261:
2257:
2253:
2249:
2245:
2241:
2235:
2231:
2227:
2222:
2217:
2213:
2209:
2205:
2200:
2196:
2192:
2188:
2184:
2180:
2176:
2170:
2166:
2162:
2158:
2154:
2150:
2146:
2143:(4): 451–64.
2142:
2138:
2133:
2132:
2127:
2119:
2115:
2110:
2105:
2101:
2097:
2093:
2086:
2083:
2078:
2074:
2069:
2064:
2060:
2056:
2052:
2048:
2044:
2037:
2034:
2029:
2025:
2021:
2017:
2013:
2009:
2001:
1998:
1993:
1989:
1984:
1979:
1975:
1971:
1967:
1960:
1957:
1952:
1948:
1943:
1938:
1934:
1930:
1926:
1922:
1918:
1911:
1909:
1905:
1900:
1896:
1892:
1888:
1884:
1880:
1876:
1872:
1864:
1861:
1856:
1852:
1848:
1844:
1840:
1836:
1829:
1826:
1821:
1817:
1812:
1807:
1803:
1799:
1796:(2): 138–43.
1795:
1791:
1787:
1780:
1777:
1772:
1768:
1764:
1760:
1755:
1750:
1747:(2): 243–54.
1746:
1742:
1738:
1731:
1728:
1715:
1708:
1702:
1699:
1694:
1690:
1685:
1680:
1676:
1672:
1668:
1661:
1658:
1653:
1649:
1644:
1639:
1634:
1629:
1625:
1621:
1617:
1613:
1609:
1602:
1600:
1596:
1591:
1587:
1582:
1577:
1573:
1569:
1566:(3): 874–85.
1565:
1561:
1557:
1550:
1547:
1542:
1538:
1534:
1530:
1527:(4): 249–63.
1526:
1522:
1514:
1512:
1508:
1503:
1497:
1495:
1491:
1486:
1482:
1478:
1474:
1470:
1466:
1458:
1455:
1450:
1446:
1440:
1437:
1432:
1428:
1422:
1419:
1415:
1411:
1406:
1404:
1402:
1398:
1394:
1390:
1385:
1383:
1381:
1377:
1371:
1369:
1367:
1363:
1359:
1355:
1351:
1343:
1341:
1339:
1335:
1331:
1327:
1323:
1319:
1314:
1312:
1308:
1304:
1300:
1296:
1292:
1288:
1284:
1280:
1276:
1268:
1266:
1263:
1259:
1255:
1251:
1247:
1242:
1240:
1236:
1232:
1231:somatic cells
1228:
1224:
1220:
1215:
1213:
1209:
1205:
1201:
1197:
1193:
1185:
1183:
1181:
1177:
1173:
1169:
1165:
1161:
1157:
1153:
1150:subfamily of
1149:
1141:
1139:
1137:
1134:
1130:
1126:
1122:
1110:
1105:
1101:
1097:
1094:
1090:
1083:
1081:
1078:
1074:
1070:
1066:
1063:
1059:
1055:
1048:
1046:
1042:
1038:
1032:
1028:
1025:
1019:
1017:
1013:
1009:
1003:
999:
996:
992:
985:
983:
979:
975:
969:
965:
962:
956:
954:
950:
946:
940:
936:
933:
931:RefSeq (mRNA)
929:
922:
921:
916:
912:
909:
903:
902:
897:
893:
890:
888:
884:
877:
876:
871:
867:
864:
858:
857:
852:
848:
845:
843:
839:
832:
831:
826:
822:
819:
813:
812:
807:
803:
800:
798:
794:
791:
788:
786:
783:
779:
776:
772:
768:
761:
757:
752:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
700:cell division
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
672:
670:
667:
666:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
620:
617:
615:
612:
610:
607:
605:
602:
601:
599:
596:
595:
589:
586:
584:
581:
579:
576:
574:
571:
569:
566:
564:
561:
559:
556:
554:
551:
549:
546:
545:
543:
540:
539:
536:
535:Gene ontology
532:
528:
516:
511:
507:
502:
499:
497:
493:
485:
480:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
432:
429:
425:
420:
417:
408:apex of heart
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
370:
367:
363:
358:
355:
354:
351:
349:
345:
343:
342:
338:
337:
334:
332:
328:
324:
320:
316:
308:
303:
299:
295:
290:
280:
276:
269:
262:
256:
249:
241:
237:
233:
228:
224:
219:
215:
207:
202:
198:
194:
189:
179:
175:
168:
161:
155:
148:
144:
138:
134:
130:
125:
121:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
72:
64:
59:
52:
47:
42:
38:
33:
27:
19:
2536:
2530:
2492:(5): 661–5.
2489:
2485:
2448:
2444:
2411:
2407:
2382:
2378:
2353:
2349:
2324:
2320:
2292:
2288:
2243:
2239:
2211:
2207:
2178:
2174:
2140:
2136:
2099:
2095:
2085:
2050:
2046:
2036:
2011:
2007:
2000:
1973:
1969:
1959:
1927:(3): e1106.
1924:
1920:
1874:
1870:
1863:
1847:10.2741/e814
1838:
1834:
1828:
1793:
1789:
1779:
1744:
1740:
1730:
1718:. Retrieved
1713:
1701:
1674:
1670:
1660:
1615:
1611:
1563:
1559:
1549:
1524:
1520:
1471:(3): 406–9.
1468:
1464:
1457:
1448:
1439:
1430:
1421:
1347:
1344:Interactions
1315:
1272:
1243:
1216:
1189:
1164:microtubules
1145:
1132:
1124:
1120:
1119:
1041:NP_001074435
1037:NP_001074434
1034:
1012:NP_001015879
1008:NP_001015878
1005:
978:NM_001080966
974:NM_001080965
971:
949:NM_001015879
945:NM_001015878
942:
918:
899:
873:
854:
828:
809:
789:
784:
649:cytoskeleton
470:spermatocyte
384:right testis
346:
339:
66:External IDs
26:
2096:Development
1322:spermatozoa
1289:and tumors
1250:microtubule
1246:kinetochore
1223:fibroblasts
1200:cytokinesis
735:cytokinesis
583:ATP binding
380:left testis
204:57,235,548
191:57,231,009
44:Identifiers
2445:Cell Cycle
1671:Cell Cycle
1416:, May 2017
1395:, May 2017
1372:References
1354:C-terminal
1307:histone H3
1295:nocodazole
1281:, and its
1262:Aneuploidy
1212:Drosophila
1208:C. elegans
1168:centrosome
725:cell cycle
619:chromosome
450:blastocyst
350:(ortholog)
305:7,006,090
292:6,998,299
87:HomoloGene
1279:repressor
1239:oogenesis
1045:NP_065597
1016:NP_003151
982:NM_020572
953:NM_003160
775:Orthologs
604:cytoplasm
95:GeneCards
2552:Category
2514:22001399
2506:17435757
2473:19776435
2465:16258285
2436:30043722
2428:15938719
2399:15917996
2370:15670791
2341:15499654
2311:15316025
2268:14671302
2230:10066797
2165:25350728
2157:12884918
2118:21613325
2077:23175282
2028:22888167
1992:24484996
1951:24603334
1891:25990457
1855:28930610
1820:23075505
1771:22742575
1763:21710690
1693:19713763
1652:22046298
1612:PLOS ONE
1590:11784863
1541:15499654
1465:Genomics
1412:–
1391:–
1366:borealin
1362:survivin
1219:anaphase
1186:Function
1160:Aurora B
1156:Aurora A
1142:Function
1093:Wikidata
754:Sources:
462:testicle
392:testicle
183:19q13.43
2276:6682593
2248:Bibcode
2240:Science
2195:9809744
2068:3729939
1942:3973241
1899:9094864
1811:5586725
1643:3203144
1620:Bibcode
1485:9799611
1414:Ensembl
1393:Ensembl
1338:DPY19L2
1291:in vivo
1256:(SAC),
1225:, with
1176:mitosis
1172:spindle
1123:, also
887:UniProt
842:Ensembl
781:Species
760:QuickGO
710:meiosis
659:nucleus
629:midbody
609:spindle
325:pattern
83:1321119
51:Aliases
2528:Human
2512:
2504:
2471:
2463:
2434:
2426:
2397:
2368:
2339:
2309:
2274:
2266:
2228:
2193:
2163:
2155:
2116:
2075:
2065:
2026:
1990:
1949:
1939:
1897:
1889:
1853:
1818:
1808:
1769:
1761:
1720:30 Jun
1691:
1650:
1640:
1588:
1581:133550
1578:
1539:
1483:
1364:, and
1148:Aurora
1129:enzyme
1127:is an
1079:search
1077:PubMed
920:O88445
901:Q9UQB9
797:Entrez
496:BioGPS
466:embryo
446:morula
438:zygote
404:spleen
372:oocyte
75:603495
2537:AURKC
2531:AURKC
2510:S2CID
2469:S2CID
2432:S2CID
2272:S2CID
2161:S2CID
1895:S2CID
1767:S2CID
1710:(PDF)
1299:BubR1
1204:yeast
1133:AURKC
830:20871
790:Mouse
785:Human
756:Amigo
396:sperm
388:gonad
348:Mouse
341:Human
288:Start
223:Mouse
187:Start
120:Human
99:AURKC
91:68302
58:AURKC
35:AURKC
2502:PMID
2461:PMID
2424:PMID
2395:PMID
2366:PMID
2337:PMID
2307:PMID
2264:PMID
2226:PMID
2191:PMID
2153:PMID
2114:PMID
2073:PMID
2024:PMID
1988:PMID
1947:PMID
1887:PMID
1851:PMID
1816:PMID
1759:PMID
1722:2018
1689:PMID
1648:PMID
1586:PMID
1537:PMID
1481:PMID
1332:and
1311:MCAK
1309:and
1301:and
1275:PLZF
1237:and
1227:mRNA
1210:and
1158:and
1136:gene
811:6795
331:Bgee
279:Band
240:Chr.
178:Band
137:Chr.
71:OMIM
2494:doi
2453:doi
2416:doi
2387:doi
2358:doi
2354:328
2329:doi
2297:doi
2293:279
2256:doi
2244:302
2216:doi
2212:274
2183:doi
2145:doi
2104:doi
2100:138
2063:PMC
2055:doi
2016:doi
1978:doi
1974:101
1937:PMC
1929:doi
1879:doi
1843:doi
1806:PMC
1798:doi
1749:doi
1745:225
1679:doi
1638:PMC
1628:doi
1576:PMC
1568:doi
1529:doi
1473:doi
1305:of
1241:).
1198:to
301:End
200:End
103:OMA
79:MGI
2554::
2508:.
2500:.
2490:39
2488:.
2484:.
2467:.
2459:.
2447:.
2430:.
2422:.
2412:10
2410:.
2393:.
2383:12
2381:.
2364:.
2352:.
2335:.
2325:59
2323:.
2305:.
2291:.
2287:.
2270:.
2262:.
2254:.
2242:.
2224:.
2210:.
2206:.
2189:.
2179:17
2177:.
2159:.
2151:.
2141:22
2139:.
2112:.
2098:.
2094:.
2071:.
2061:.
2051:13
2049:.
2045:.
2022:.
2012:27
2010:.
1986:.
1972:.
1968:.
1945:.
1935:.
1923:.
1919:.
1907:^
1893:.
1885:.
1875:36
1873:.
1849:.
1839:10
1837:.
1814:.
1804:.
1794:22
1792:.
1788:.
1765:.
1757:.
1743:.
1739:.
1712:.
1687:.
1673:.
1669:.
1646:.
1636:.
1626:.
1614:.
1610:.
1598:^
1584:.
1574:.
1564:22
1562:.
1558:.
1535:.
1525:59
1523:.
1510:^
1493:^
1479:.
1469:53
1467:.
1447:.
1429:.
1400:^
1379:^
1313:.
1196:G2
1138:.
758:/
307:bp
294:bp
206:bp
193:bp
101:;
97::
93:;
89::
85:;
81::
77:;
73::
2544:.
2516:.
2496::
2475:.
2455::
2449:4
2438:.
2418::
2401:.
2389::
2372:.
2360::
2343:.
2331::
2313:.
2299::
2278:.
2258::
2250::
2232:.
2218::
2197:.
2185::
2167:.
2147::
2120:.
2106::
2079:.
2057::
2030:.
2018::
1994:.
1980::
1953:.
1931::
1925:5
1901:.
1881::
1857:.
1845::
1822:.
1800::
1773:.
1751::
1724:.
1695:.
1681::
1675:8
1654:.
1630::
1622::
1616:6
1592:.
1570::
1543:.
1531::
1504:.
1487:.
1475::
1451:.
1433:.
1170:/
225:)
122:)
105::
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
