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Sunitinib inhibits cellular signaling by targeting multiple receptor tyrosine kinases (RTKs). These include all receptors for platelet-derived growth factor (PDGFR) and vascular endothelial growth factor receptors (VEGFR), which play a role in both tumor angiogenesis and tumor cell proliferation. The
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and clarification of the multi-specific mechanism of action is partly based on discoveries of Axel
Ullrich and his team at the Max Planck Institute of Biochemistry in the 1980s in Munich. The discovery, medical and pharmaceutical development as well as clinical testing of the drug was carried out by
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at the
Institute of Medical Biology aimed at identifying all oncogenic alterations in all protein tyrosine kinase (PTK) gene transcripts of a large number of tumor cell lines and primary tumors. The laboratory also focuses on functional characterization and, in cooperation with clinical oncologists,
404:
or VEGFR) suppresses the generation of blood vessels in tumors and slows down cancer cell growth. Years later, a small molecule inhibitor of the VEGFR2 kinase function was developed, from which a derivative was approved in 2006 for the treatment of kidney carcinoma and gastro-intestinal stromal
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tissue sample from a surgeon in Munich. The tumor had just been extracted from a woman. Ullrich purified the insulin mRNA from this sample and cloned it into a vector that he inserted into E coli. Thus, he produced a strain of E coli that would manufacture human insulin.
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of living biologists. Among many other achievements, he and his team have co-discovered two groups of receptor tyrosine kinases. In some tumours, (the cancerous state), some receptor tyrosine kinases tend to be over-active, due to genetic changes.
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Ullrich was the first person to clone a human gene, insulin, into E coli. He was one of the first employees of
Genentech. While working for Genentech in 1979, he obtained a human
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investigation of the clinical relevance of the newly discovered PTK oncogenes which serves as basis for the development of novel multi-targeted drugs.
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simultaneous inhibition of these targets therefore leads to both reduced tumor vascularization and cancer cell death, and ultimately tumor shrinkage.
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282:. Ullrich has received Hamdan Award for Medical Research Excellence, awarded by Sheikh Hamdan bin Rashid Al Maktoum Award for Medical Sciences,
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in San
Francisco from 1978 to 1988. From 1988, he has been at the Max Planck Institute of Biochemistry.
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In the early 1990s, Ullrich and his team identified the signaling system involved in regulating tumor
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2008 Pezcoller
Foundation-AACR International Award for Extraordinary Achievement in Cancer Research
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He was one of several scientific leaders of 200+ scientists in developing the anti-cancer drug
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586:"Winners of the Emanuel Merck Lectureship and the Heinrich Emanuel Merck Award".
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692:"Elected Member of the Hungarian Academy of Sciences Professor Dr. Axel Ullrich"
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research on human proto-oncogenes and development of novel cancer therapies.
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278:, Germany since 1988. This department's research has primarily focused on
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Officers
Crosses of the Order of Merit of the Federal Republic of Germany
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2008 Hamdan Award for
Medical Research Excellence - Therapy in Malignancy
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678:"Honorary Doctor of Semmelweis University Professor Dr. Axel Ullrich"
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345:) at Genentech, and has co-founded five biotech companies, Axxima,
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630:"Wolf-Preis für Rastatter Ehrenbürger Professor Dr. Axel Ullrich"
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in molecular genetics in 1975. He did post-doctoral work at the
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65:
from the article and its talk page, especially if potentially
20:
505:"Genentech and Axel Ulrich clone the human insulin gene"
322:, from 1975 to 1977 and worked as a senior scientist at
480:"King-Faisal-Forschungspreis geht 2003 an Axel Ullrich"
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652:"2010 THE 2010 WOLF FOUNDATION PRIZE IN MEDICINE"
750:CV at the Max-Planck Institute for Biochemistry
1226:University of California, San Francisco alumni
459:Lasker-DeBakey Clinical Medical Research Award
290:in 2008 and Ullrich and his team received the
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8:
266:researcher and has been the director of the
402:vascular endothelial growth factor receptor
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763:
755:
372:Ullrich is also Principal Investigator of
140:
58:about living persons that is unsourced or
385:about 100+ scientists and physicians, at
129:Learn how and when to remove this message
563:. University of Debrecen. Archived from
310:, Germany, he received a Ph.D. from the
588:Angewandte Chemie International Edition
561:"Debrecen Award for Molecular Medicine"
471:
302:Ullrich received his primary degree in
196:University of California, San Francisco
428:Debrecen Award for Molecular Medicine
7:
358:Institute for Scientific Information
272:Max Planck Institute of Biochemistry
240:Max Planck Institute of Biochemistry
262:(born 19 October 1943) is a German
14:
654:. Wolf foundation. Archived from
594:(16). Wiley: 4124. 6 April 2018.
364:and he is also in the top ten of
1231:Wolf Prize in Medicine laureates
25:
1246:Max Planck Institute directors
1:
453:Hungarian Academy of Sciences
349:, Kinaxo, SUGEN (acquired by
745:Singapore Oncogenome Project
374:Singapore Oncogenome Project
36:biography of a living person
1241:Fellows of the AACR Academy
1216:German molecular biologists
451:2013 Elected Member of the
63:must be removed immediately
1262:
632:. ka-news. 4 February 2010
380:The discovery of the drug
434:Emanuel Merck Lectureship
253:
225:
445:2012 Honorary Doctor of
360:(ISI) as a highly cited
316:University of California
312:University of Heidelberg
191:University of Heidelberg
16:German cancer researcher
1164:Lynne Elizabeth Maquat
1150:Emmanuelle Charpentier
787:Wolf Prize in Medicine
600:10.1002/anie.201802009
308:University of Tübingen
219:Wolf Prize in Medicine
186:University of Tübingen
50:Please help by adding
537:. GBM. Archived from
447:Semmelweis University
1002:Alexander Varshavsky
904:Elizabeth F. Neufeld
864:Jean-Pierre Changeux
858:Stanley Norman Cohen
705:Hofschneider, Mark.
535:"Otto-Warburg-Medal"
485:. Max Planck Society
356:He is listed by the
288:United Arab Emirates
56:Contentious material
1133:Jeffrey M. Friedman
959:Stanley B. Prusiner
740:ISI page on Ullrich
658:on 26 February 2009
567:on 27 December 2014
515:on 16 December 2018
280:signal transduction
1221:German oncologists
1111:Jeffrey V. Ravetch
1032:Alexander Levitzki
953:Yasutomi Nishizuka
854:Barbara McClintock
541:on 4 November 2016
416:Otto Warburg Medal
353:) and Blackfield.
270:department at the
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1174:Daniel J. Drucker
1036:Anthony R. Hunter
1008:Ralph L. Brinster
890:Pedro Cuatrecasas
878:Donald F. Steiner
868:Solomon H. Snyder
823:Oleh Hornykiewicz
785:Laureates of the
735:Ullrich biography
711:Lasker Foundation
409:Honors and awards
268:molecular biology
257:
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227:Scientific career
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39:needs additional
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1127:James P. Allison
1117:Lewis C. Cantley
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1016:Oliver Smithies
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298:Life and work
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1180:Botond Roska
1103:John Kappler
1067:Axel Ullrich
1066:
1050:Aharon Razin
1046:Howard Cedar
971:Michael Sela
965:Mary F. Lyon
894:Meir Wilchek
815:Roger Sperry
805:Jean Dausset
801:George Snell
714:. Retrieved
710:
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660:. Retrieved
656:the original
646:
634:. Retrieved
624:
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569:. Retrieved
565:the original
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543:. Retrieved
539:the original
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517:. Retrieved
513:the original
508:
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487:. Retrieved
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398:angiogenesis
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304:biochemistry
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260:Axel Ullrich
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233:Institutions
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145:Axel Ullrich
125:
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85:
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62:
45:verification
38:
18:
1206:1943 births
1160:Joan Steitz
1093:Gary Ruvkun
1040:Tony Pawson
981:Eric Kandel
910:John Gurdon
716:13 December
509:Tacomed.com
339:Trastuzumab
276:Martinsried
1200:Categories
975:Ruth Arnon
545:12 January
466:References
440:Wolf Prize
331:insulinoma
292:Wolf Prize
157:1943-10-19
119:March 2010
89:newspapers
844:Leo Sachs
608:1433-7851
571:7 January
382:Sunitinib
362:biologist
347:U3 Pharma
343:Herceptin
324:Genentech
294:in 2010.
245:Genentech
209:Sunitinib
41:citations
1018:(2002/3)
967:(1996/7)
961:(1995/6)
955:(1994/5)
880:(1984/5)
616:29631331
405:tumors.
67:libelous
662:2 April
636:2 April
519:13 June
489:2 April
366:H-index
306:at the
172:Silesia
103:scholar
1186:(2024)
1176:(2023)
1170:(2021)
1156:(2020)
1135:(2019)
1129:(2017)
1123:(2016)
1113:(2015)
1099:(2014)
1085:(2012)
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933:(1990)
916:(1989)
906:(1988)
896:(1987)
886:(1986)
874:(1982)
860:(1981)
850:(1980)
825:(1979)
811:(1978)
707:"HOME"
614:
606:
351:Pfizer
264:cancer
221:(2010)
215:Awards
168:Lauban
105:
98:
91:
84:
76:
1143:2020s
1060:2010s
991:2000s
924:1990s
833:1980s
794:1970s
483:(PDF)
457:2019
438:2010
432:2009
426:2009
414:2005
387:SUGEN
284:Dubai
110:JSTOR
96:books
34:This
718:2021
664:2010
638:2010
612:PMID
604:ISSN
573:2015
547:2014
521:2017
491:2010
151:Born
82:news
43:for
596:doi
274:in
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