Knowledge

Azemiglitazone

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Harrison, Stephen A.; Alkhouri, Naim; Davison, Beth A.; Sanyal, Arun; Edwards, Christopher; Colca, Jerry R.; Lee, Bo Hyun; Loomba, Rohit; Cusi, Kenneth; Kolterman, Orville; Cotter, Gad; Dittrich, Howard C. (April 2020). "Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized,
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Colca, Jerry R.; Lee, Bo Hyun; Iwashita, Julie S.; Dittrich, Howard C.; Harrison, Stephen A. (1 June 2020). "1090-P: MSDC-0602k, a New Oral Insulin Sensitizer in Insulin Resistant NASH Patients with and without Type 2 Diabetes (T2D)".
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InChI=1S/C19H17NO5S/c1-24-15-4-2-3-13(10-15)16(21)11-25-14-7-5-12(6-8-14)9-17-18(22)20-19(23)26-17/h2-8,10,17H,9,11H2,1H3,(H,20,22,23)
468:"Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide" 367: 316: 362:
binding. It is hoped to have fewer adverse effects than the thiazolidinediones and is being developed by Cirius Therapeutics for
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Kamm, Dakota R.; Pyles, Kelly D.; Sharpe, Martin C.; Healy, Laura N.; Colca, Jerry R.; McCommis, Kyle S. (January 2021).
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Experimental drugs developed for non-alcoholic fatty liver disease
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COC1=CC=CC(=C1)C(=O)COC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
270: 257: 224: 219: 199: 179: 159: 139: 114: 94: 69: 53: 48: 40: 35: 128: 103: 44:Azemiglitazone potassium; MSDC-0602; MSDC-0602K 558: 8: 19: 86:5-phenyl]methyl]-1,3-thiazolidine-2,4-dione 565: 551: 168: 27: 493: 483: 377:, azemiglitazone potassium (MSDC-0602K). 188: 386: 321: 301: 148: 83: 18: 208: 7: 519: 517: 119: 14: 368:non-alcoholic fatty liver disease 350:designed to retain the effect of 521: 242: 236: 472:Journal of Biological Chemistry 356:mitochondrial pyruvate carriers 329:Key:YAUMOGALQJYOJQ-UHFFFAOYSA-N 251: 245: 230: 1: 537:. You can help Knowledge by 584:Experimental diabetes drugs 370:. It is formulated as its 630: 516: 445:10.1016/j.jhep.2019.10.023 220:Chemical and physical data 599:3-Methoxyphenyl compounds 485:10.1016/j.jbc.2021.100807 312: 292: 74: 26: 533:-related article is a 433:Journal of Hepatology 409:10.2337/db20-1090-P 23: 614:Pharmacology stubs 594:Thiazolidinediones 352:thiazolidinediones 348:insulin sensitizer 546: 545: 337: 336: 283:Interactive image 16:Chemical compound 621: 567: 560: 553: 525: 518: 508: 507: 497: 487: 463: 457: 456: 427: 421: 420: 403:(Supplement_1). 391: 285: 265: 253: 247: 244: 238: 232: 212: 192: 172: 152: 132: 122: 121: 107: 31: 24: 22: 629: 628: 624: 623: 622: 620: 619: 618: 609:Aromatic ethers 574: 573: 572: 571: 514: 512: 511: 465: 464: 460: 429: 428: 424: 393: 392: 388: 383: 364:type 2 diabetes 333: 330: 325: 320: 319: 308: 305: 300: 299: 288: 263: 250: 241: 235: 215: 195: 175: 155: 135: 118: 110: 90: 87: 82: 81: 65: 62:Investigational 17: 12: 11: 5: 627: 625: 617: 616: 611: 606: 601: 596: 591: 586: 576: 575: 570: 569: 562: 555: 547: 544: 543: 526: 510: 509: 458: 439:(4): 613–626. 422: 385: 384: 382: 379: 340:Azemiglitazone 335: 334: 332: 331: 328: 326: 323: 315: 314: 313: 310: 309: 307: 306: 303: 295: 294: 293: 290: 289: 287: 286: 278: 276: 268: 267: 261: 255: 254: 248: 239: 233: 228: 222: 221: 217: 216: 214: 213: 205: 203: 197: 196: 194: 193: 185: 183: 177: 176: 174: 173: 165: 163: 157: 156: 154: 153: 145: 143: 137: 136: 134: 133: 125: 123: 112: 111: 109: 108: 100: 98: 92: 91: 89: 88: 85: 77: 76: 75: 72: 71: 67: 66: 64: 63: 59: 57: 51: 50: 46: 45: 42: 38: 37: 33: 32: 21:Azemiglitazone 15: 13: 10: 9: 6: 4: 3: 2: 626: 615: 612: 610: 607: 605: 602: 600: 597: 595: 592: 590: 587: 585: 582: 581: 579: 568: 563: 561: 556: 554: 549: 548: 542: 540: 536: 532: 527: 524: 520: 515: 505: 501: 496: 491: 486: 481: 477: 473: 469: 462: 459: 454: 450: 446: 442: 438: 434: 426: 423: 418: 414: 410: 406: 402: 398: 390: 387: 380: 378: 376: 373: 369: 365: 361: 358:with limited 357: 353: 349: 346:) is a novel 345: 341: 327: 322: 318: 311: 302: 298: 291: 284: 280: 279: 277: 274: 269: 262: 260: 256: 229: 227: 223: 218: 211: 210:ChEMBL4291468 207: 206: 204: 202: 198: 191: 187: 186: 184: 182: 178: 171: 167: 166: 164: 162: 158: 151: 147: 146: 144: 142: 138: 131: 127: 126: 124: 117: 113: 106: 102: 101: 99: 97: 93: 84: 80: 73: 68: 61: 60: 58: 56: 52: 47: 43: 39: 36:Clinical data 34: 30: 25: 539:expanding it 531:pharmacology 528: 513: 475: 471: 461: 436: 432: 425: 400: 396: 389: 343: 339: 338: 105:1133819-87-0 55:Legal status 49:Legal status 266: g·mol 70:Identifiers 41:Other names 578:Categories 478:: 100807. 381:References 360:PPAR-gamma 271:3D model ( 259:Molar mass 190:81MXZ6QOBM 161:ChemSpider 96:CAS Number 79:IUPAC name 417:225824217 372:potassium 344:MSDC-0602 504:34022222 453:31697972 397:Diabetes 170:32698412 141:DrugBank 130:25230266 604:Ketones 495:8192871 226:Formula 150:DB16028 116:PubChem 502:  492:  451:  415:  297:SMILES 264:371.41 201:ChEMBL 529:This 413:S2CID 317:InChI 273:JSmol 535:stub 500:PMID 449:PMID 375:salt 366:and 181:UNII 490:PMC 480:doi 476:296 441:doi 405:doi 354:on 120:CID 580:: 498:. 488:. 474:. 470:. 447:. 437:72 435:. 411:. 401:69 399:. 240:17 234:19 566:e 559:t 552:v 541:. 506:. 482:: 455:. 443:: 419:. 407:: 342:( 275:) 252:S 249:5 246:O 243:N 237:H 231:C

Index


Legal status
IUPAC name
CAS Number
1133819-87-0
PubChem
25230266
DrugBank
DB16028
ChemSpider
32698412
UNII
81MXZ6QOBM
ChEMBL
ChEMBL4291468
Formula
Molar mass
JSmol
Interactive image
SMILES
InChI
insulin sensitizer
thiazolidinediones
mitochondrial pyruvate carriers
PPAR-gamma
type 2 diabetes
non-alcoholic fatty liver disease
potassium
salt
doi

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