242:
219:
1193:(ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, CFTR/MRP, ALD (adrenoleukodystrophy), OABP, GCN20, and White. This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral
116:
141:
493:
248:
147:
1285:
1253:
More rapid endocytosis of amyloid precursor protein was observed in primary microglia from ABCA7 deficient mice. Roles of ABCA7 are also implicated for microglial phagocytotic function and immune responses. Although the direct target of ABCA7 function is unclear, the findings are so far mechanistically consistent with the increased AΞ² production.
1231:
ABCA7 was shown associated with cellular phagocytotic activity. The promoter of ABCA7 contains sterol regulatory element (SRE) so that ABCA7 is down-regulated by cell cholesterol through sterol regulatory element binding protein (SREBP) 2. Therefore, ABCA7 expression and phagocytosis are up-regulated
1252:
By using the knock-out mice, ABCA7 was indicated involved in generation and processing of amyloid Ξ² (AΞ²) peptides. In the brain of the amyloid precursor protein transgenic mice, deletion of ABCA7 resulted in accumulation of AΞ²40 and AΞ²42 in the early stage apparently by accelerating AΞ² production.
1244:
In 2011, two genome-wide association studies (GWAS) identified ABCA7 as a new susceptibility locus for late-onset
Alzheimer's disease. The finding was also confirmed by other meta-analysis investigations later. Such association of ABCA7 variants was reported on more specific findings of the disease
1227:
On the other hand, transfected and expressed ABCA7, but not endogenous ABCA7, mediates release of cell phospholipid and cholesterol to generate HDL-like particles but contain less cholesterol than those generated by ABCA1. ABCA7-generated HDL is smaller and appears as a single peak in a molecular
1235:
In summary, ABCA7 is a substantially related protein to ABCA1 but it does not mediate cell cholesterol release by generation of HDL unless it is externally transfected and expressed in vitro. ABCA7 is shown associated with cellular phagocytotic function in vivo and in vitro, and expression of the
1223:
Lack of ABCA7 gene exhibits phenotypes in mice, such as moderate decrease in plasma HDL and adipose tissues only in female, while release of cellular cholesterol and phospholipid is not impaired. Accordingly, decrease in plasma lectin level was also reported. Reduction of CD3 or CD1d may lead to
1256:
The data can be summarized as 1) loss of function of ABCA7 is associated with a risk for late onset
Alzheimer's disease, 2) one of its molecular backgrounds can be enhanced production/decreased processing of AΞ² peptides, and 3) ABCA7 is at least shown to increase phagocytosis including that of
1228:
sieve HPLC analysis in comparison to HDL generated by ABCA1 that shows twin peaks of small and poor in cholesterol and large and rich in cholesterol. ABCA7 mRNA generates full length cDNA and a spliced form of cDNA, and only the former is capable of generating HDL when transfected.
1248:
Protein-disrupting variants in ABCA7 have been shown to predispose to
Alzheimer's disease. The Icelandic database of Decode Genetics has shown a doubled probability of developing Alzheimer's disease when inactive variants of the ABCA7 gene are present.
3802:
1257:
microglia. Since ABCA7 gene is down-regulated by cell cholesterol via the SRE/SREBP system, the data accumulated are consistent with clinical implication that use of statins, HMG-CoA reductase inhibitors, reduces risk for
Alzheimer's disease.
1236:
ABCA7 gene is regulated by cell cholesterol mainly through the SRE/SREBP system in a negative feed-back fashion in contrast to positive feedback by the LXR/RXR system for ABCA1. ABCA7 thus links cholesterol metabolism to host defense system.
3056:
Broccardo C, Osorio J, Luciani MF, Schriml LM, Prades C, Shulenin S, et al. (2001). "Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter".
3807:
3096:"Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8"
3026:
Tanaka AR, Ikeda Y, Abe-Dohmae S, Arakawa R, Sadanami K, Kidera A, et al. (May 2001). "Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of SjΓΆgren's
Syndrome".
2997:
Kaminski WE, Piehler A, Schmitz G (November 2000). "Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene".
3234:
Ikeda Y, Abe-Dohmae S, Munehira Y, Aoki R, Kawamoto S, Furuya A, et al. (November 2003). "Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release".
1851:
Ikeda Y, Abe-Dohmae S, Munehira Y, Aoki R, Kawamoto S, Furuya A, et al. (November 2003). "Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release".
1232:
by use of HMG-reductase inhibitors (statins). In addition, ABCA7 is stabilized like ABCA1 by helical apolipoproteins such as apoA-I, and phagocytosis is accordingly increased in such a condition.
3166:"Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: a potential role for ABCA7 in epidermal lipid reorganization"
2476:
Ramirez LM, Goukasian N, Porat S, Hwang KS, Eastman JA, Hurtz S, et al. (March 2016). "Common variants in ABCA7 and MS4A6A are associated with cortical and hippocampal atrophy".
2617:
Steinberg S, Stefansson H, Jonsson T, Johannsdottir H, Ingason A, Helgason H, et al. (May 2015). "Loss-of-function variants in ABCA7 confer risk of
Alzheimer's disease".
3627:
2939:
Kaminski WE, OrsΓ³ E, Diederich W, Klucken J, Drobnik W, Schmitz G (July 2000). "Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7)".
255:
154:
3541:
1685:"Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels"
1476:"Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels"
3263:
Fu GK, Wang JT, Yang J, Au-Young J, Stuve LL (July 2004). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes".
3812:
3446:
3414:
896:
877:
77:
3602:
2331:"Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E Ο΅4,and the risk of late-onset Alzheimer disease in African Americans"
3797:
1439:
1421:
3424:
2968:
Niwa M, Maruyama H, Fujimoto T, Dohi K, Maruyama IN (October 2000). "Affinity selection of cDNA libraries by lambda phage surface display".
1307:"ABCA7 links sterol metabolism to the host defense system: Molecular background for potential management measure of Alzheimer's disease"
1796:"ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content"
1628:"ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content"
1734:"Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1"
1569:"Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1"
241:
3470:
2089:"ApoA-I facilitates ABCA1 recycle/accumulation to cell surface by inhibiting its intracellular degradation and increases HDL generation"
3777:
3387:
2666:
1115:
218:
3201:"Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein"
3131:"ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux"
1108:
2791:
Fu Y, Hsiao JH, Paxinos G, Halliday GM, Kim WS (September 2016). "ABCA7 Mediates
Phagocytic Clearance of Amyloid-Ξ² in the Brain".
2570:"A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy"
1460:
2040:"Helical apolipoproteins stabilize ATP-binding cassette transporter A1 by protecting it from thiol protease-mediated degradation"
1266:
1190:
1408:
1387:
3439:
2141:"Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7"
140:
115:
1404:
3399:
3329:"ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages"
1942:"ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages"
1383:
57:
2429:"Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease"
1292:
The 2020 version of this article was updated by an external expert under a dual publication model. The corresponding
254:
153:
3463:
1893:"ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis"
247:
146:
3432:
3381:
941:
65:
922:
2282:"Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease"
1520:"Deletion of Alzheimer's Disease Risk Gene ABCA7 Alters White Adipose Tissue Development and Leptin Levels"
3632:
2233:"Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease"
1293:
129:
2887:"Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease"
1991:"HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7"
2839:
2519:
Schott JM, Crutch SJ, Carrasquillo MM, Uphill J, Shakespeare TJ, Ryan NS, et al. (August 2016).
2378:
Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, et al. (December 2013).
1807:
1745:
1639:
1580:
1245:
such as memory decline and incident mild cognitive impairment or cortical and hippocampal atrophy.
1209:. The function of this protein is not yet known; however, the expression pattern suggests a role in
3405:
3393:
3129:
Wang N, Lan D, Gerbod-Giannone M, Linsel-Nitschke P, Jehle AW, Chen W, et al. (October 2003).
2427:
Carrasquillo MM, Crook JE, Pedraza O, Thomas CS, Pankratz VS, Allen M, et al. (January 2015).
2380:"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease"
2192:"Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor"
1087:
1040:
3377:
2693:"ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing"
2231:
Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, et al. (May 2011).
44:
3327:
Jehle AW, Gardai SJ, Li S, Linsel-Nitschke P, Morimoto K, Janssen WJ, et al. (August 2006).
3082:
2652:
2501:
2118:
2069:
1940:
Jehle AW, Gardai SJ, Li S, Linsel-Nitschke P, Morimoto K, Janssen WJ, et al. (August 2006).
1922:
1714:
89:
3164:
Kielar D, Kaminski WE, Liebisch G, Piehler A, Wenzel JJ, MΓΆhle C, et al. (September 2003).
2826:
Aikawa T, Ren Y, Yamazaki Y, Tachibana M, Johnson MR, Anderson CT, et al. (November 2019).
1794:
Nowyhed HN, Chandra S, Kiosses W, Marcovecchio P, Andary F, Zhao M, et al. (January 2017).
1626:
Nowyhed HN, Chandra S, Kiosses W, Marcovecchio P, Andary F, Zhao M, et al. (January 2017).
1091:
1066:
1036:
1015:
1011:
3358:
3315:
3280:
3251:
3222:
3187:
3152:
3117:
3074:
3044:
3014:
2985:
2956:
2916:
2867:
2808:
2773:
2724:
2644:
2599:
2550:
2493:
2458:
2409:
2360:
2311:
2262:
2213:
2172:
2110:
2061:
2020:
1971:
1914:
1868:
1833:
1773:
1706:
1665:
1608:
1549:
1497:
1342:
1324:
492:
37:
3455:
3348:
3340:
3305:
3272:
3243:
3212:
3177:
3142:
3107:
3066:
3036:
3006:
2977:
2948:
2906:
2898:
2857:
2847:
2800:
2763:
2755:
2742:
Sakae N, Liu CC, Shinohara M, Frisch-Daiello J, Ma L, Yamazaki Y, et al. (March 2016).
2714:
2704:
2634:
2626:
2589:
2581:
2540:
2532:
2485:
2448:
2440:
2399:
2391:
2350:
2342:
2301:
2293:
2252:
2244:
2203:
2162:
2152:
2100:
2051:
2010:
2002:
1961:
1953:
1904:
1860:
1823:
1815:
1763:
1753:
1696:
1683:
Kim WS, Fitzgerald ML, Kang K, Okuhira K, Bell SA, Manning JJ, et al. (February 2005).
1655:
1647:
1598:
1588:
1539:
1531:
1487:
1474:
Kim WS, Fitzgerald ML, Kang K, Okuhira K, Bell SA, Manning JJ, et al. (February 2005).
1350:
1332:
1316:
334:
265:
209:
164:
1732:
Meurs I, Calpe-Berdiel L, Habets KL, Zhao Y, Korporaal SJ, Mommaas AM, et al. (2012).
1567:
Meurs I, Calpe-Berdiel L, Habets KL, Zhao Y, Korporaal SJ, Mommaas AM, et al. (2012).
85:
3466:
3459:
3199:
Abe-Dohmae S, Ikeda Y, Matsuo M, Hayashi M, Okuhira K, Ueda K, Yokoyama S (January 2004).
2006:
309:
2489:
2444:
2843:
2521:"Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease"
2329:
Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BN, Wang LS, et al. (April 2013).
1811:
1749:
1643:
1584:
3536:
3353:
3328:
2911:
2886:
2862:
2827:
2768:
2743:
2719:
2692:
2594:
2569:
2545:
2520:
2453:
2428:
2404:
2379:
2355:
2330:
2306:
2281:
2257:
2232:
2167:
2140:
2015:
1990:
1966:
1941:
1828:
1795:
1768:
1733:
1660:
1627:
1603:
1568:
1544:
1519:
1337:
1311:
1306:
2981:
2744:"ABCA7 Deficiency Accelerates Amyloid-Ξ² Generation and Alzheimer's Neuronal Pathology"
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
675:
670:
665:
660:
655:
650:
645:
640:
635:
630:
625:
620:
615:
610:
605:
600:
595:
579:
574:
569:
564:
559:
554:
549:
544:
539:
534:
3791:
3418:
3182:
3165:
2656:
2505:
1217:
521:
3086:
2568:
Chen JA, Wang Q, Davis-Turak J, Li Y, Karydas AM, Hsu SC, et al. (April 2015).
2280:
Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, et al. (May 2011).
2122:
2073:
1926:
1718:
69:
2759:
327:
106:
2902:
2691:
Satoh K, Abe-Dohmae S, Yokoyama S, St George-Hyslop P, Fraser PE (October 2015).
2585:
1758:
1593:
93:
3276:
1444:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1426:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1213:
1206:
3310:
3293:
3247:
3094:
Iida A, Saito S, Sekine A, Mishima C, Kitamura Y, Kondo K, et al. (2002).
2832:
Proceedings of the
National Academy of Sciences of the United States of America
2828:"ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain"
2536:
2139:
Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S (September 2010).
2105:
2088:
1909:
1892:
1864:
1320:
410:
226:
123:
73:
1328:
2852:
2709:
1989:
Tanaka N, Abe-Dohmae S, Iwamoto N, Fitzgerald ML, Yokoyama S (August 2011).
1354:
1194:
841:
470:
348:
293:
280:
192:
179:
81:
3803:
Knowledge (XXG) articles with corresponding academic peer reviewed articles
3362:
3319:
3284:
3255:
3226:
3217:
3200:
3191:
3156:
3147:
3130:
3121:
3078:
3048:
3040:
3018:
3010:
2989:
2960:
2952:
2920:
2871:
2812:
2777:
2728:
2648:
2603:
2554:
2497:
2462:
2413:
2364:
2346:
2315:
2266:
2217:
2208:
2191:
2176:
2114:
2065:
2056:
2039:
2024:
1975:
1918:
1872:
1837:
1777:
1710:
1701:
1684:
1669:
1612:
1553:
1501:
1492:
1475:
1346:
3344:
3112:
3095:
1957:
1155:
1150:
3755:
1284:
1139:
986:
967:
3294:"Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7"
2639:
2157:
1461:"Entrez Gene: ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7"
1220:. Alternative splicing of this gene results in two transcript variants.
2804:
1535:
1171:
953:
908:
3808:
Knowledge (XXG) articles with corresponding articles published in Gene
3292:
Hayashi M, Abe-Dohmae S, Okazaki M, Ueda K, Yokoyama S (August 2005).
3070:
1819:
1651:
3656:
3651:
3646:
3581:
3520:
3515:
1202:
1198:
1123:
863:
742:
negative regulation of amyloid precursor protein biosynthetic process
2630:
2395:
2087:
Lu R, Arakawa R, Ito-Osumi C, Iwamoto N, Yokoyama S (October 2008).
2885:
Zissimopoulos JM, Barthold D, Brinton RD, Joyce G (February 2017).
2297:
2248:
1189:
The protein encoded by this gene is a member of the superfamily of
3763:
3759:
3750:
3745:
3740:
3724:
3719:
3703:
3687:
3682:
3677:
3672:
3640:
3636:
3622:
3617:
3612:
3607:
3597:
3576:
3571:
3566:
3561:
3556:
3510:
3500:
3495:
3490:
3485:
1210:
826:
822:
3550:
3545:
1178:
501:
61:
48:, ABCA-SSN, ABCX, AD9, ATP binding cassette subfamily A member 7
3428:
1518:
Bhatia S, Fu Y, Hsiao JT, Halliday GM, Kim WS (December 2017).
1891:
Iwamoto N, Abe-Dohmae S, Sato R, Yokoyama S (September 2006).
1278:
812:
positive regulation of protein localization to cell surface
802:
regulation of amyloid precursor protein catabolic process
317:
1305:
Sumiko Abe-Dohmae; Shinji Yokoyama (19 November 2020).
482:
797:
amyloid-beta clearance by cellular catabolic process
3733:
3712:
3696:
3665:
3590:
3529:
3478:
3236:
Biochemical and Biophysical Research Communications
3029:
Biochemical and Biophysical Research Communications
2999:
Biochemical and Biophysical Research Communications
2941:
Biochemical and Biophysical Research Communications
2190:Costet P, Luo Y, Wang N, Tall AR (September 2000).
1853:
Biochemical and Biophysical Research Communications
1080:
1059:
1029:
1004:
762:
positive regulation of engulfment of apoptotic cell
2093:Arteriosclerosis, Thrombosis, and Vascular Biology
1400:
1398:
1396:
1379:
1377:
1375:
570:ATPase-coupled transmembrane transporter activity
264:
163:
1789:
1787:
16:Protein-coding gene in the species Homo sapiens
1513:
1511:
1405:GRCm38: Ensembl release 89: ENSMUSG00000035722
626:ATP-binding cassette (ABC) transporter complex
3440:
1224:dysfunction of T cells by deletion of ABCA7.
767:negative regulation of amyloid-beta formation
757:positive regulation of amyloid-beta clearance
737:apolipoprotein A-I-mediated signaling pathway
8:
752:positive regulation of ERK1 and ERK2 cascade
1384:GRCh38: Ensembl release 89: ENSG00000064687
3447:
3433:
3425:
3415:United States National Library of Medicine
1168:ATP-binding cassette sub-family A member 7
837:
772:positive regulation of phospholipid efflux
692:high-density lipoprotein particle assembly
517:
305:
204:
101:
3380:at the U.S. National Library of Medicine
3352:
3309:
3216:
3181:
3146:
3111:
2910:
2861:
2851:
2767:
2718:
2708:
2638:
2593:
2544:
2452:
2403:
2354:
2305:
2256:
2207:
2166:
2156:
2104:
2055:
2014:
1965:
1908:
1827:
1767:
1757:
1700:
1659:
1602:
1592:
1543:
1491:
1336:
717:positive regulation of cholesterol efflux
445:fetal liver hematopoietic progenitor cell
3413:This article incorporates text from the
3170:The Journal of Investigative Dermatology
1455:
1453:
616:intracellular membrane-bounded organelle
1371:
1524:Journal of Alzheimer's Disease Reports
18:
2686:
2684:
2682:
2134:
2132:
2007:10.1016/j.atherosclerosis.2011.06.031
1886:
1884:
1882:
555:phosphatidylcholine floppase activity
269:
230:
225:
168:
127:
122:
7:
2490:10.1016/j.neurobiolaging.2015.10.037
2445:10.1016/j.neurobiolaging.2014.07.042
560:apolipoprotein A-I receptor activity
550:phosphatidylserine floppase activity
3205:The Journal of Biological Chemistry
3135:The Journal of Biological Chemistry
2697:The Journal of Biological Chemistry
2196:The Journal of Biological Chemistry
2044:The Journal of Biological Chemistry
2038:Arakawa R, Yokoyama S (June 2002).
1689:The Journal of Biological Chemistry
1480:The Journal of Biological Chemistry
1315:. Gene Wiki Review Series: 145316.
747:positive regulation of phagocytosis
1077:
1056:
1026:
1001:
977:
958:
932:
913:
887:
868:
792:negative regulation of endocytosis
487:
405:
343:
322:
14:
3813:ATP-binding cassette transporters
1174:that in humans is encoded by the
807:plasma membrane raft organization
3183:10.1046/j.1523-1747.2003.12404.x
1283:
1267:ATP-binding cassette transporter
491:
253:
246:
240:
217:
152:
145:
139:
114:
2667:"Iceland lays bare its genomes"
732:protein localization to nucleus
3059:Cytogenetics and Cell Genetics
2793:Journal of Alzheimer's Disease
2760:10.1523/JNEUROSCI.3757-15.2016
596:integral component of membrane
502:More reference expression data
471:More reference expression data
379:olfactory zone of nasal mucosa
375:right hemisphere of cerebellum
1:
2982:10.1016/S0378-1119(00)00348-6
238:
137:
3798:Genes on human chromosome 19
2903:10.1001/jamaneurol.2016.3783
2665:Ashley Yeager (2015-03-15).
2586:10.1001/jamaneurol.2014.4040
1759:10.1371/journal.pone.0030984
1594:10.1371/journal.pone.0030984
3464:membrane transport proteins
3392:human gene location in the
3333:The Journal of Cell Biology
3277:10.1016/j.ygeno.2004.01.011
2748:The Journal of Neuroscience
1946:The Journal of Cell Biology
3829:
3404:human gene details in the
3311:10.1194/jlr.M500092-JLR200
3248:10.1016/j.bbrc.2003.10.002
2537:10.1016/j.jalz.2016.01.010
2525:Alzheimer's & Dementia
2106:10.1161/ATVBAHA.108.169482
1910:10.1194/jlr.M600127-JLR200
1865:10.1016/j.bbrc.2003.10.002
1321:10.1016/J.GENE.2020.145316
707:phospholipid translocation
575:lipid transporter activity
437:superior cervical ganglion
383:mucosa of transverse colon
3778:ABC transporter disorders
3773:
3298:Journal of Lipid Research
3100:Journal of Human Genetics
2145:Journal of Lipid Research
1897:Journal of Lipid Research
1440:"Mouse PubMed Reference:"
1422:"Human PubMed Reference:"
1296:article was published in
1154:
1149:
1145:
1138:
1122:
1103:
1084:
1063:
1052:
1033:
1008:
997:
984:
980:
965:
961:
952:
939:
935:
920:
916:
907:
894:
890:
875:
871:
862:
847:
840:
836:
820:
520:
516:
499:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
3382:Medical Subject Headings
1116:Chr 10: 79.83 β 79.85 Mb
2853:10.1073/pnas.1908529116
2710:10.1074/jbc.M115.655076
777:transmembrane transport
611:early endosome membrane
433:interventricular septum
3218:10.1074/jbc.M309888200
3148:10.1074/jbc.M307831200
3041:10.1006/bbrc.2001.4891
3011:10.1006/bbrc.2000.3880
2953:10.1006/bbrc.2000.2954
2347:10.1001/jama.2013.2973
2209:10.1074/jbc.M003337200
2057:10.1074/jbc.M202996200
1702:10.1074/jbc.M412602200
1493:10.1074/jbc.M412602200
1294:academic peer reviewed
1109:Chr 19: 1.04 β 1.07 Mb
787:amyloid-beta formation
453:mesenteric lymph nodes
425:lumbar spinal ganglion
271:10 C1|10 39.72 cM
3345:10.1083/jcb.200601030
3113:10.1007/s100380200041
2478:Neurobiology of Aging
2433:Neurobiology of Aging
1958:10.1083/jcb.200601030
1240:Clinical significance
722:peptide cross-linking
671:endoplasmic reticulum
661:glial cell projection
387:minor salivary glands
232:Chromosome 10 (mouse)
130:Chromosome 19 (human)
3378:ABCA7+protein,+human
1302:and can be cited as:
1191:ATP-binding cassette
565:transporter activity
3406:UCSC Genome Browser
3394:UCSC Genome Browser
3141:(44): 42906β42912.
2844:2019PNAS..11623790A
2838:(47): 23790β23796.
2703:(40): 24152β24165.
2202:(36): 28240β28245.
2158:10.1194/jlr.M006049
2050:(25): 22426β22429.
1812:2017NatSR...740273N
1750:2012PLoSO...730984M
1644:2017NatSR...740273N
1585:2012PLoSO...730984M
727:phospholipid efflux
449:islet of Langerhans
3417:, which is in the
2805:10.3233/JAD-160456
1800:Scientific Reports
1632:Scientific Reports
1536:10.3233/ADR-170029
942:ENSMUSG00000035722
697:cholesterol efflux
685:Biological process
589:Cellular component
535:nucleotide binding
528:Molecular function
429:tibiofemoral joint
363:anterior pituitary
3785:
3784:
3456:Membrane proteins
3071:10.1159/000056914
2754:(13): 3848β3859.
2390:(12): 1452β1458.
2341:(14): 1483β1492.
2099:(10): 1820β1824.
1820:10.1038/srep40273
1652:10.1038/srep40273
1363:
1362:
1165:
1164:
1161:
1160:
1134:
1133:
1099:
1098:
1074:
1073:
1048:
1047:
1023:
1022:
993:
992:
974:
973:
948:
947:
929:
928:
903:
902:
884:
883:
832:
831:
512:
511:
508:
507:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
94:ABCA7 - orthologs
3820:
3460:carrier proteins
3449:
3442:
3435:
3426:
3366:
3356:
3323:
3313:
3304:(8): 1703β1711.
3288:
3259:
3230:
3220:
3195:
3185:
3160:
3150:
3125:
3115:
3090:
3065:(3β4): 264β270.
3052:
3035:(5): 1019β1025.
3022:
2993:
2976:(1β2): 229β236.
2964:
2925:
2924:
2914:
2882:
2876:
2875:
2865:
2855:
2823:
2817:
2816:
2788:
2782:
2781:
2771:
2739:
2733:
2732:
2722:
2712:
2688:
2677:
2674:
2663:Lay summary in:
2660:
2642:
2614:
2608:
2607:
2597:
2565:
2559:
2558:
2548:
2516:
2510:
2509:
2473:
2467:
2466:
2456:
2424:
2418:
2417:
2407:
2375:
2369:
2368:
2358:
2326:
2320:
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2309:
2277:
2271:
2270:
2260:
2228:
2222:
2221:
2211:
2187:
2181:
2180:
2170:
2160:
2151:(9): 2591β2599.
2136:
2127:
2126:
2108:
2084:
2078:
2077:
2059:
2035:
2029:
2028:
2018:
1986:
1980:
1979:
1969:
1937:
1931:
1930:
1912:
1903:(9): 1915β1927.
1888:
1877:
1876:
1848:
1842:
1841:
1831:
1791:
1782:
1781:
1771:
1761:
1729:
1723:
1722:
1704:
1695:(5): 3989β3995.
1680:
1674:
1673:
1663:
1623:
1617:
1616:
1606:
1596:
1564:
1558:
1557:
1547:
1515:
1506:
1505:
1495:
1486:(5): 3989β3995.
1471:
1465:
1464:
1457:
1448:
1447:
1436:
1430:
1429:
1418:
1412:
1402:
1391:
1381:
1358:
1340:
1287:
1279:
1216:in cells of the
1147:
1146:
1118:
1111:
1094:
1078:
1069:
1057:
1053:RefSeq (protein)
1043:
1027:
1018:
1002:
978:
959:
933:
914:
888:
869:
838:
518:
504:
495:
488:
473:
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
3828:
3827:
3823:
3822:
3821:
3819:
3818:
3817:
3788:
3787:
3786:
3781:
3769:
3729:
3708:
3692:
3661:
3586:
3525:
3474:
3467:ABC transporter
3453:
3374:
3369:
3326:
3291:
3262:
3233:
3198:
3163:
3128:
3093:
3055:
3025:
2996:
2967:
2938:
2934:
2932:Further reading
2929:
2928:
2884:
2883:
2879:
2825:
2824:
2820:
2790:
2789:
2785:
2741:
2740:
2736:
2690:
2689:
2680:
2664:
2631:10.1038/ng.3246
2619:Nature Genetics
2616:
2615:
2611:
2567:
2566:
2562:
2518:
2517:
2513:
2475:
2474:
2470:
2426:
2425:
2421:
2396:10.1038/ng.2802
2384:Nature Genetics
2377:
2376:
2372:
2328:
2327:
2323:
2286:Nature Genetics
2279:
2278:
2274:
2237:Nature Genetics
2230:
2229:
2225:
2189:
2188:
2184:
2138:
2137:
2130:
2086:
2085:
2081:
2037:
2036:
2032:
1995:Atherosclerosis
1988:
1987:
1983:
1939:
1938:
1934:
1890:
1889:
1880:
1850:
1849:
1845:
1793:
1792:
1785:
1731:
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1682:
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1677:
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1566:
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1509:
1473:
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1459:
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1438:
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1415:
1403:
1394:
1382:
1373:
1368:
1359:
1304:
1303:
1288:
1275:
1263:
1242:
1187:
1156:View/Edit Mouse
1151:View/Edit Human
1114:
1107:
1104:Location (UCSC)
1090:
1086:
1065:
1039:
1035:
1014:
1010:
923:ENSG00000064687
816:
782:lipid transport
680:
676:cell projection
656:ruffle membrane
636:plasma membrane
606:Golgi apparatus
584:
580:protein binding
540:ATPase activity
500:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
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377:
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231:
208:Gene location (
190:
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169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
3826:
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3698:
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3690:
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3675:
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3594:
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3498:
3493:
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3437:
3429:
3410:
3409:
3397:
3385:
3373:
3372:External links
3370:
3368:
3367:
3339:(4): 547β556.
3324:
3289:
3271:(1): 205β210.
3260:
3242:(2): 313β318.
3231:
3211:(1): 604β611.
3196:
3176:(3): 465β474.
3161:
3126:
3106:(6): 285β310.
3091:
3053:
3023:
3005:(3): 782β789.
2994:
2965:
2947:(2): 532β538.
2935:
2933:
2930:
2927:
2926:
2897:(2): 225β232.
2891:JAMA Neurology
2877:
2818:
2799:(2): 569β584.
2783:
2734:
2678:
2676:
2675:
2625:(5): 445β447.
2609:
2580:(4): 414β422.
2574:JAMA Neurology
2560:
2531:(8): 862β871.
2511:
2468:
2419:
2370:
2321:
2298:10.1038/ng.801
2292:(5): 436β441.
2272:
2249:10.1038/ng.803
2243:(5): 429β435.
2223:
2182:
2128:
2079:
2030:
2001:(2): 407β414.
1981:
1952:(4): 547β556.
1932:
1878:
1859:(2): 313β318.
1843:
1783:
1724:
1675:
1618:
1559:
1530:(1): 237β247.
1507:
1466:
1449:
1431:
1413:
1392:
1370:
1369:
1367:
1364:
1361:
1360:
1291:
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673:
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646:phagocytic cup
643:
638:
633:
631:Golgi membrane
628:
623:
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310:RNA expression
302:
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2:
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3419:public domain
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2640:11250/296499
2622:
2618:
2612:
2577:
2573:
2563:
2528:
2524:
2514:
2481:
2477:
2471:
2439:(1): 60β67.
2436:
2432:
2422:
2387:
2383:
2373:
2338:
2334:
2324:
2289:
2285:
2275:
2240:
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2199:
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1226:
1222:
1188:
1175:
1167:
1166:
1088:NP_001334010
1085:
1064:
1041:NM_001347081
1034:
1009:
985:
966:
940:
921:
895:
876:
856:
851:
702:phagocytosis
651:cell surface
333:
326:
53:External IDs
2671:ScienceNews
1214:homeostasis
1207:bone marrow
545:ATP binding
457:bone marrow
421:granulocyte
359:granulocyte
292:79,851,406
279:79,832,328
31:Identifiers
3792:Categories
1411:, May 2017
1390:, May 2017
1366:References
1355:Q102319919
1195:leukocytes
395:lymph node
337:(ortholog)
191:1,065,572
178:1,040,101
74:HomoloGene
3776:see also
2657:205349727
2506:195675085
2484:: 82β89.
1806:: 40273.
1638:: 40273.
1329:0378-1119
1092:NP_038878
1067:NP_061985
1037:NM_013850
1016:NM_033308
1012:NM_019112
842:Orthologs
666:cytoplasm
82:GeneCards
3756:Sterolin
3363:16908670
3320:15930518
3285:15203218
3265:Genomics
3256:14592415
3227:14570867
3192:12925201
3157:12917409
3122:12111378
3087:29664964
3079:11435699
3049:11355874
3019:11095984
2990:11054552
2961:10873640
2921:27942728
2872:31690660
2813:27472885
2778:27030769
2729:26260791
2649:25807283
2604:25706306
2555:26993346
2498:26923404
2463:25189118
2414:24162737
2365:23571587
2316:21460841
2267:21460840
2218:10858438
2177:20495215
2123:13492156
2115:18617649
2074:27052533
2066:11950847
2025:21762915
1976:16908670
1927:23145752
1919:16788211
1873:14592415
1838:28091533
1778:22403608
1738:PLOS ONE
1719:24263492
1711:15550377
1670:28091533
1613:22403608
1573:PLOS ONE
1554:30480241
1502:15550377
1407:–
1386:–
1351:Wikidata
1347:33221536
1261:See also
1185:Function
1140:Wikidata
821:Sources:
621:membrane
601:endosome
391:monocyte
3354:2064260
2912:5646357
2863:6876254
2840:Bibcode
2769:4812140
2720:4591804
2595:4397175
2546:4982482
2454:4268433
2405:3896259
2356:3667653
2307:3090745
2258:3084173
2168:2918442
2016:3150192
1967:2064260
1829:5238393
1808:Bibcode
1769:3293875
1746:Bibcode
1661:5238393
1640:Bibcode
1604:3293875
1581:Bibcode
1545:6159609
1409:Ensembl
1388:Ensembl
1338:7959064
1172:protein
954:UniProt
909:Ensembl
848:Species
827:QuickGO
312:pattern
170:19p13.3
70:1351646
38:Aliases
3471:TC 3A1
3384:(MeSH)
3361:
3351:
3318:
3283:
3254:
3225:
3190:
3155:
3120:
3085:
3077:
3047:
3017:
2988:
2959:
2919:
2909:
2870:
2860:
2811:
2776:
2766:
2727:
2717:
2655:
2647:
2602:
2592:
2553:
2543:
2504:
2496:
2461:
2451:
2412:
2402:
2363:
2353:
2314:
2304:
2265:
2255:
2216:
2175:
2165:
2121:
2113:
2072:
2064:
2023:
2013:
1974:
1964:
1925:
1917:
1871:
1836:
1826:
1776:
1766:
1717:
1709:
1668:
1658:
1611:
1601:
1552:
1542:
1500:
1353:
1345:
1335:
1327:
1205:, and
1203:spleen
1199:thymus
1126:search
1124:PubMed
987:Q91V24
968:Q8IZY2
864:Entrez
712:memory
483:BioGPS
371:spleen
62:605414
3401:ABCA7
3389:ABCA7
3083:S2CID
2653:S2CID
2502:S2CID
2119:S2CID
2070:S2CID
1923:S2CID
1715:S2CID
1299:Gene
1273:Notes
1211:lipid
1176:ABCA7
1170:is a
897:27403
878:10347
857:Mouse
852:Human
823:Amigo
441:blood
367:blood
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
86:ABCA7
78:22783
45:ABCA7
22:ABCA7
3633:C8-9
3542:B2-3
3359:PMID
3316:PMID
3281:PMID
3252:PMID
3223:PMID
3188:PMID
3153:PMID
3118:PMID
3075:PMID
3045:PMID
3015:PMID
2986:PMID
2970:Gene
2957:PMID
2917:PMID
2868:PMID
2809:PMID
2774:PMID
2725:PMID
2645:PMID
2600:PMID
2551:PMID
2494:PMID
2459:PMID
2410:PMID
2361:PMID
2335:JAMA
2312:PMID
2263:PMID
2214:PMID
2173:PMID
2111:PMID
2062:PMID
2021:PMID
1972:PMID
1915:PMID
1869:PMID
1834:PMID
1774:PMID
1707:PMID
1666:PMID
1609:PMID
1550:PMID
1498:PMID
1343:PMID
1325:ISSN
1312:Gene
1179:gene
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
3657:C13
3652:C11
3647:C10
3582:B11
3521:A13
3516:A12
3349:PMC
3341:doi
3337:174
3306:doi
3273:doi
3244:doi
3240:311
3213:doi
3209:279
3178:doi
3174:121
3143:doi
3139:278
3108:doi
3067:doi
3037:doi
3033:283
3007:doi
3003:278
2978:doi
2974:256
2949:doi
2945:273
2907:PMC
2899:doi
2858:PMC
2848:doi
2836:116
2801:doi
2764:PMC
2756:doi
2715:PMC
2705:doi
2701:290
2635:hdl
2627:doi
2590:PMC
2582:doi
2541:PMC
2533:doi
2486:doi
2449:PMC
2441:doi
2400:PMC
2392:doi
2351:PMC
2343:doi
2339:309
2302:PMC
2294:doi
2253:PMC
2245:doi
2204:doi
2200:275
2163:PMC
2153:doi
2101:doi
2052:doi
2048:277
2011:PMC
2003:doi
1999:217
1962:PMC
1954:doi
1950:174
1905:doi
1861:doi
1857:311
1824:PMC
1816:doi
1764:PMC
1754:doi
1697:doi
1693:280
1656:PMC
1648:doi
1599:PMC
1589:doi
1540:PMC
1532:doi
1488:doi
1484:280
1333:PMC
1317:doi
288:End
187:End
90:OMA
66:MGI
3794::
3764:G8
3762:,
3760:G5
3751:G4
3746:G2
3741:G1
3725:F2
3720:F1
3704:E1
3688:D4
3683:D3
3678:D2
3673:D1
3641:C9
3639:,
3637:C8
3628:C7
3623:C6
3618:C5
3613:C4
3608:C3
3603:C2
3598:C1
3577:B9
3572:B7
3567:B6
3562:B5
3557:B4
3551:B3
3546:B2
3537:B1
3511:A8
3506:A7
3501:A4
3496:A3
3491:A2
3486:A1
3462::
3458:,
3357:.
3347:.
3335:.
3331:.
3314:.
3302:46
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3296:.
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212:)
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92::
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