2936:
297:
1116:. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member
274:
171:
196:
2394:
548:
303:
202:
50:
2095:
Remaley AT, Bark S, Walts AD, Freeman L, Shulenin S, Annilo T, Elgin E, Rhodes HE, Joyce C, Dean M, Santamarina-Fojo S, Brewer HB (Jul 2002). "Comparative genome analysis of potential regulatory elements in the ABCG5-ABCG8 gene cluster".
1667:
Berge KE, Tian H, Graf GA, Yu L, Grishin NV, Schultz J, Kwiterovich P, Shan B, Barnes R, Hobbs HH (Dec 2000). "Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters".
1461:
1149:
2058:
Heimerl S, Langmann T, Moehle C, Mauerer R, Dean M, Beil FU, von
Bergmann K, Schmitz G (Aug 2002). "Mutations in the human ATP-binding cassette transporters ABCG5 and ABCG8 in sitosterolemia".
1711:
Lu K, Lee MH, Hazard S, Brooks-Wilson A, Hidaka H, Kojima H, Ose L, Stalenhoef AF, Mietinnen T, Bjorkhem I, Bruckert E, Pandya A, Brewer HB, Salen G, Dean M, Srivastava A, Patel SB (Aug 2001).
1713:"Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively"
2660:
3158:
3138:
310:
209:
2842:
3186:
2435:
2935:
2574:
3250:
2479:
2447:
1816:
Patel SB, Salen G, Hidaka H, Kwiterovich PO, Stalenhoef AF, Miettinen TA, Grundy SM, Lee MH, Rubenstein JS, Polymeropoulos MH, Brownstein MJ (Sep 1998).
831:
812:
132:
2635:
1859:
Lee MH, Lu K, Hazard S, Yu H, Shulenin S, Hidaka H, Kojima H, Allikmets R, Sakuma N, Pegoraro R, Srivastava AK, Salen G, Dean M, Patel SB (Jan 2001).
3048:
3081:
1904:"An ATP-binding cassette gene (ABCG5) from the ABCG (White) gene subfamily maps to human chromosome 2p21 in the region of the Sitosterolemia locus"
1501:
1189:
1504:
1192:
1474:
1162:
1649:
1631:
2457:
3240:
3113:
2835:
1473:
1161:
1492:
1180:
296:
2503:
2428:
2810:
2369:
1508:
1196:
1038:
1031:
273:
3076:
2170:"Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol"
1763:
1494:
1182:
3196:
2899:
2248:"ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin"
1113:
1505:
1193:
3245:
2828:
1618:
1597:
2472:
2421:
2017:"Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8"
1818:"Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21"
1614:
1471:
1159:
1120:. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with
2375:
1507:
1487:
1481:
1476:
1195:
1175:
1169:
1164:
195:
170:
47:
3086:
3068:
1499:
1479:
1187:
1167:
1593:
2885:
1531:
1472:
1160:
112:
1490:
1489:
1468:
1178:
1177:
1156:
1509:
1498:
1485:
1484:
1483:
1197:
1186:
1173:
1172:
1171:
309:
208:
1502:
1488:
1190:
1176:
2496:
1986:
Lam CW, Cheng AW, Tong SF, Chan YW (Feb 2002). "Novel donor splice site mutation of ABCG5 gene in sitosterolemia".
1506:
1503:
1194:
1191:
302:
201:
2465:
1486:
1174:
1512:
1511:
1469:
1465:
1200:
1199:
1157:
1153:
2920:
2362:
1510:
1500:
1497:
1496:
1495:
1480:
1478:
1477:
1475:
1467:
1466:
1464:
1198:
1188:
1185:
1184:
1183:
1168:
1166:
1165:
1163:
1155:
1154:
1152:
876:
120:
1493:
1482:
1470:
1181:
1170:
1158:
2127:"Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface"
1491:
1179:
2904:
857:
3096:
2665:
1570:
2316:
Yu L, Gupta S, Xu F, Liverman AD, Moschetta A, Mangelsdorf DJ, Repa JJ, Hobbs HH, Cohen JC (Mar 2005).
2213:"ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion"
1677:
184:
99:
2925:
2381:
2358:
3058:
2083:
1974:
1931:
144:
1861:"Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption"
1014:
993:
967:
946:
3000:
2995:
2990:
2985:
2955:
2895:
2339:
2304:
2269:
2234:
2199:
2156:
2113:
2075:
2046:
2003:
1966:
1923:
1890:
1847:
1804:
1742:
1693:
92:
40:
2405:
1945:"Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia"
3027:
3017:
3012:
3007:
2977:
2488:
2401:
2393:
2329:
2294:
2259:
2224:
2189:
2181:
2146:
2138:
2105:
2067:
2036:
2028:
1995:
1956:
1915:
1880:
1872:
1837:
1829:
1794:
1732:
1724:
1685:
389:
320:
264:
219:
3173:
3148:
2318:"Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion"
2281:
Freeman LA, Kennedy A, Wu J, Bark S, Remaley AT, Santamarina-Fojo S, Brewer HB (Jul 2004).
547:
140:
3022:
2820:
2499:
2492:
364:
1681:
3053:
2944:
2915:
2569:
2041:
2016:
1885:
1860:
1737:
1712:
1121:
2194:
2169:
2151:
2126:
2109:
2032:
1842:
1817:
1799:
1782:
1764:"Entrez Gene: ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1)"
1552:
1535:
1522:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
680:
675:
670:
665:
660:
655:
650:
645:
629:
624:
619:
614:
609:
604:
599:
594:
589:
3234:
2451:
576:
2087:
1978:
1935:
1460:
1148:
124:
3181:
2876:
2168:
Yu L, Li-Hawkins J, Hammer RE, Berge KE, Horton JD, Cohen JC, Hobbs HH (Sep 2002).
382:
161:
1902:
Shulenin S, Schriml LM, Remaley AT, Fojo S, Brewer B, Allikmets R, Dean M (2001).
1689:
2283:"The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter"
148:
2891:
2880:
2864:
2855:
1654:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1636:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2299:
2282:
2264:
2247:
2125:
Graf GA, Li WP, Gerard RD, Gelissen I, White A, Cohen JC, Hobbs HH (Sep 2002).
465:
1133:
Click on genes, proteins and metabolites below to link to respective articles.
281:
178:
128:
776:
525:
403:
348:
335:
247:
234:
136:
2343:
2334:
2317:
2308:
2273:
2246:
Kajinami K, Brousseau ME, Nartsupha C, Ordovas JM, Schaefer EJ (Apr 2004).
2238:
2229:
2212:
2203:
2160:
2117:
2079:
2050:
2007:
1999:
1970:
1927:
1894:
1808:
1746:
1697:
1851:
1078:
1073:
2788:
1062:
921:
902:
2211:
Graf GA, Yu L, Li WP, Gerard R, Tuma PL, Cohen JC, Hobbs HH (Nov 2003).
1094:
888:
843:
2071:
2015:
Lu K, Lee MH, Yu H, Zhou Y, Sandell SA, Salen G, Patel SB (Apr 2002).
1961:
1944:
1919:
69:
3105:
3040:
2689:
2684:
2679:
2614:
2553:
2548:
2185:
2142:
1046:
798:
1903:
1833:
1728:
1112:
The protein encoded by this gene is a member of the superfamily of
3216:
3206:
3168:
3163:
3123:
2970:
2965:
2960:
2851:
2796:
2783:
2778:
2773:
2757:
2752:
2736:
2720:
2715:
2710:
2705:
2673:
2669:
2655:
2650:
2645:
2640:
2630:
2609:
2604:
2599:
2594:
2589:
2543:
2538:
2533:
2528:
2523:
2518:
1876:
1117:
1783:"Role of ABCG1 and other ABCG family members in lipid metabolism"
761:
757:
3153:
3143:
3133:
3128:
3118:
2583:
2578:
1101:
556:
116:
2824:
2461:
1459:
1147:
1550:
The interactive pathway map can be edited at WikiPathways:
722:
negative regulation of intestinal cholesterol absorption
712:
negative regulation of intestinal phytosterol absorption
372:
103:, STSL, ATP binding cassette subfamily G member 5, STSL2
2409:
1943:
Hubacek JA, Berge KE, Cohen JC, Hobbs HH (Oct 2001).
537:
3195:
3095:
3067:
3038:
2943:
2863:
2766:
2745:
2729:
2698:
2623:
2562:
2511:
2098:
1007:
986:
960:
939:
1610:
1608:
1606:
1589:
1587:
1585:
620:ATPase-coupled transmembrane transporter activity
319:
218:
1463:
1151:
16:Protein-coding gene in the species Homo sapiens
1615:GRCm38: Ensembl release 89: ENSMUSG00000040505
656:ATP-binding cassette (ABC) transporter complex
2836:
2473:
2429:
1781:Schmitz G, Langmann T, Heimerl S (Oct 2001).
630:xenobiotic transmembrane transporter activity
8:
1594:GRCh38: Ensembl release 89: ENSG00000138075
2843:
2829:
2821:
2480:
2466:
2458:
2448:United States National Library of Medicine
2436:
2422:
1091:ATP-binding cassette sub-family G member 5
772:
572:
360:
259:
156:
58:
2361:at the U.S. National Library of Medicine
2333:
2298:
2263:
2228:
2193:
2150:
2040:
1960:
1884:
1841:
1798:
1736:
2446:This article incorporates text from the
1758:
1756:
1581:
1543:
1114:ATP-binding cassette (ABC) transporters
496:crypt of lieberkuhn of small intestine
18:
2174:The Journal of Clinical Investigation
2131:The Journal of Clinical Investigation
1822:The Journal of Clinical Investigation
676:integral component of plasma membrane
324:
285:
280:
223:
182:
177:
7:
2390:
2388:
2322:The Journal of Biological Chemistry
2217:The Journal of Biological Chemistry
615:protein heterodimerization activity
2408:. You can help Knowledge (XXG) by
1717:American Journal of Human Genetics
1004:
983:
957:
936:
912:
893:
867:
848:
822:
803:
732:xenobiotic transmembrane transport
542:
460:
398:
377:
14:
3251:ATP-binding cassette transporters
1988:Molecular Genetics and Metabolism
1097:that in humans is encoded by the
717:intestinal cholesterol absorption
2934:
2392:
546:
308:
301:
295:
272:
207:
200:
194:
169:
1908:Cytogenetics and Cell Genetics
697:response to ionizing radiation
646:integral component of membrane
557:More reference expression data
526:More reference expression data
1:
2110:10.1016/S0006-291X(02)00652-6
2033:10.1016/S0022-2275(20)31486-3
1800:10.1016/S0022-2275(20)32205-7
1690:10.1126/science.290.5497.1771
610:cholesterol transfer activity
492:epithelium of small intestine
293:
192:
3241:Genes on human chromosome 2
2497:membrane transport proteins
3267:
2387:
2380:gene details page in the
2300:10.1194/jlr.C400002-JLR200
2265:10.1194/jlr.M300278-JLR200
2932:
2811:ABC transporter disorders
2806:
2287:Journal of Lipid Research
2252:Journal of Lipid Research
2021:Journal of Lipid Research
1787:Journal of Lipid Research
1650:"Mouse PubMed Reference:"
1632:"Human PubMed Reference:"
1077:
1072:
1068:
1061:
1045:
1026:
1011:
990:
979:
964:
943:
932:
919:
915:
900:
896:
887:
874:
870:
855:
851:
842:
829:
825:
810:
806:
797:
782:
775:
771:
755:
575:
571:
554:
545:
536:
523:
472:
463:
410:
401:
371:
363:
359:
342:
329:
292:
271:
262:
258:
241:
228:
191:
168:
159:
155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
2363:Medical Subject Headings
1039:Chr 17: 84.97 – 84.99 Mb
3069:Lipid transfer proteins
1128:Interactive pathway map
1032:Chr 2: 43.81 – 43.84 Mb
747:transmembrane transport
727:cholesterol homeostasis
3246:Membrane protein stubs
3097:Cell surface receptors
2404:–related article is a
2335:10.1074/jbc.M411080200
2230:10.1074/jbc.M310223200
2000:10.1006/mgme.2001.3285
1553:"Statin_Pathway_WP430"
1515:
1203:
681:apical plasma membrane
326:17 E4|17 55.02 cM
1571:ABCG5 and ABCG8 Genes
1514:
1202:
287:Chromosome 17 (mouse)
3199:cassette transporter
2374:genome location and
2359:ABCG5+protein,+human
1521:|alt=Statin pathway
707:response to nutrient
185:Chromosome 2 (human)
62:List of PDB id codes
35:Available structures
2926:Remnant cholesterol
2858:particle metabolism
2382:UCSC Genome Browser
1682:2000Sci...290.1771B
666:apical part of cell
446:islet of Langerhans
418:right lobe of liver
2450:, which is in the
1516:
1204:
877:ENSMUSG00000040505
742:cholesterol efflux
690:Biological process
639:Cellular component
590:nucleotide binding
583:Molecular function
500:left lobe of liver
3225:
3224:
2818:
2817:
2489:Membrane proteins
2417:
2416:
2072:10.1002/humu.9047
1962:10.1002/humu.1206
1920:10.1159/000056903
1088:
1087:
1084:
1083:
1057:
1056:
1022:
1021:
1001:
1000:
975:
974:
954:
953:
928:
927:
909:
908:
883:
882:
864:
863:
838:
837:
819:
818:
767:
766:
625:metal ion binding
567:
566:
563:
562:
532:
531:
519:
518:
504:choroidal fissure
476:intestinal villus
457:
456:
438:prefrontal cortex
355:
354:
254:
253:
149:ABCG5 - orthologs
81:
80:
77:
76:
45:Ortholog search:
3258:
2938:
2867:particle classes
2845:
2838:
2831:
2822:
2493:carrier proteins
2482:
2475:
2468:
2459:
2438:
2431:
2424:
2402:membrane protein
2396:
2389:
2347:
2337:
2312:
2302:
2277:
2267:
2242:
2232:
2223:(48): 48275–82.
2207:
2197:
2186:10.1172/JCI16001
2164:
2154:
2143:10.1172/JCI16000
2121:
2091:
2054:
2044:
2011:
1982:
1964:
1939:
1898:
1888:
1855:
1845:
1812:
1802:
1768:
1767:
1760:
1751:
1750:
1740:
1708:
1702:
1701:
1676:(5497): 1771–5.
1664:
1658:
1657:
1646:
1640:
1639:
1628:
1622:
1612:
1601:
1591:
1557:
1556:
1548:
1455:
1450:
1445:
1440:
1435:
1430:
1425:
1420:
1415:
1410:
1405:
1400:
1395:
1390:
1385:
1380:
1375:
1370:
1365:
1360:
1355:
1350:
1345:
1340:
1335:
1330:
1325:
1320:
1315:
1310:
1305:
1300:
1295:
1290:
1285:
1280:
1275:
1270:
1265:
1260:
1255:
1250:
1245:
1240:
1235:
1230:
1225:
1220:
1215:
1210:
1070:
1069:
1041:
1034:
1017:
1005:
996:
984:
980:RefSeq (protein)
970:
958:
949:
937:
913:
894:
868:
849:
823:
804:
773:
661:receptor complex
573:
559:
550:
543:
528:
468:
466:Top expressed in
461:
406:
404:Top expressed in
399:
378:
361:
351:
338:
327:
312:
305:
299:
288:
276:
260:
250:
237:
226:
211:
204:
198:
187:
173:
157:
151:
102:
95:
72:
59:
53:
32:
31:
19:
3266:
3265:
3261:
3260:
3259:
3257:
3256:
3255:
3231:
3230:
3228:
3226:
3221:
3198:
3191:
3091:
3063:
3034:
2945:Apolipoproteins
2939:
2930:
2868:
2859:
2849:
2819:
2814:
2802:
2762:
2741:
2725:
2694:
2619:
2558:
2507:
2500:ABC transporter
2486:
2443:
2442:
2355:
2350:
2315:
2293:(7): 1197–206.
2280:
2245:
2210:
2167:
2124:
2094:
2057:
2014:
1985:
1942:
1901:
1865:Nature Genetics
1858:
1834:10.1172/JCI3963
1815:
1793:(10): 1513–20.
1780:
1776:
1774:Further reading
1771:
1762:
1761:
1754:
1710:
1709:
1705:
1666:
1665:
1661:
1648:
1647:
1643:
1630:
1629:
1625:
1613:
1604:
1592:
1583:
1579:
1567:
1562:
1561:
1560:
1551:
1549:
1545:
1540:
1539:
1538:
1534:Statin pathway
1533:
1528:
1527:
1526:
1520:
1519:
1518:
1517:
1513:
1457:
1456:
1453:
1451:
1448:
1446:
1443:
1441:
1438:
1436:
1433:
1431:
1428:
1426:
1423:
1421:
1418:
1416:
1413:
1411:
1408:
1406:
1403:
1401:
1398:
1396:
1393:
1391:
1388:
1386:
1383:
1381:
1378:
1376:
1373:
1371:
1368:
1366:
1363:
1361:
1358:
1356:
1353:
1351:
1348:
1346:
1343:
1341:
1338:
1336:
1333:
1331:
1328:
1326:
1323:
1321:
1318:
1316:
1313:
1311:
1308:
1306:
1303:
1301:
1298:
1296:
1293:
1291:
1288:
1286:
1283:
1281:
1278:
1276:
1273:
1271:
1268:
1266:
1263:
1261:
1258:
1256:
1253:
1251:
1248:
1246:
1243:
1241:
1238:
1236:
1233:
1231:
1228:
1226:
1223:
1221:
1218:
1216:
1213:
1211:
1208:
1205:
1201:
1130:
1110:
1079:View/Edit Mouse
1074:View/Edit Human
1037:
1030:
1027:Location (UCSC)
1013:
992:
966:
945:
858:ENSG00000138075
751:
737:lipid transport
685:
671:plasma membrane
634:
600:protein binding
595:ATPase activity
555:
524:
515:
510:
506:
502:
498:
494:
490:
486:
482:
478:
464:
453:
448:
444:
442:Brodmann area 9
440:
436:
432:
428:
426:mucosa of ileum
424:
420:
416:
402:
346:
333:
325:
315:
314:
313:
306:
286:
263:Gene location (
245:
232:
224:
214:
213:
212:
205:
183:
160:Gene location (
111:
98:
91:
68:
46:
17:
12:
11:
5:
3264:
3262:
3254:
3253:
3248:
3243:
3233:
3232:
3223:
3222:
3220:
3219:
3214:
3209:
3203:
3201:
3193:
3192:
3190:
3189:
3184:
3178:
3177:
3176:
3171:
3166:
3161:
3156:
3151:
3146:
3141:
3136:
3131:
3126:
3121:
3109:
3108:
3101:
3099:
3093:
3092:
3090:
3089:
3084:
3079:
3073:
3071:
3065:
3064:
3062:
3061:
3056:
3051:
3045:
3043:
3039:Extracellular
3036:
3035:
3033:
3032:
3031:
3030:
3020:
3015:
3010:
3005:
3004:
3003:
2998:
2993:
2988:
2980:
2975:
2974:
2973:
2968:
2963:
2958:
2949:
2947:
2941:
2940:
2933:
2931:
2929:
2928:
2923:
2918:
2913:
2910:
2907:
2902:
2888:
2883:
2872:
2870:
2869:and subclasses
2861:
2860:
2850:
2848:
2847:
2840:
2833:
2825:
2816:
2815:
2807:
2804:
2803:
2801:
2800:
2786:
2781:
2776:
2770:
2768:
2764:
2763:
2761:
2760:
2755:
2749:
2747:
2743:
2742:
2740:
2739:
2733:
2731:
2727:
2726:
2724:
2723:
2718:
2713:
2708:
2702:
2700:
2696:
2695:
2693:
2692:
2687:
2682:
2677:
2663:
2658:
2653:
2648:
2643:
2638:
2633:
2627:
2625:
2621:
2620:
2618:
2617:
2612:
2607:
2602:
2597:
2592:
2587:
2581:
2572:
2566:
2564:
2560:
2559:
2557:
2556:
2551:
2546:
2541:
2536:
2531:
2526:
2521:
2515:
2513:
2509:
2508:
2487:
2485:
2484:
2477:
2470:
2462:
2441:
2440:
2433:
2426:
2418:
2415:
2414:
2397:
2386:
2385:
2366:
2354:
2353:External links
2351:
2349:
2348:
2328:(10): 8742–7.
2313:
2278:
2243:
2208:
2165:
2122:
2092:
2060:Human Mutation
2055:
2012:
1983:
1949:Human Mutation
1940:
1914:(3–4): 204–8.
1899:
1856:
1813:
1777:
1775:
1772:
1770:
1769:
1752:
1729:10.1086/321294
1703:
1659:
1641:
1623:
1602:
1580:
1578:
1575:
1574:
1573:
1566:
1563:
1559:
1558:
1542:
1541:
1530:
1529:
1458:
1452:
1447:
1442:
1437:
1432:
1427:
1422:
1417:
1412:
1407:
1402:
1397:
1392:
1387:
1382:
1377:
1372:
1367:
1362:
1357:
1352:
1347:
1342:
1337:
1332:
1327:
1322:
1317:
1312:
1307:
1302:
1297:
1292:
1287:
1282:
1277:
1272:
1267:
1262:
1257:
1252:
1247:
1242:
1237:
1232:
1227:
1222:
1217:
1212:
1207:
1206:
1146:
1145:
1144:
1143:
1141:
1140:
1139:
1138:
1137:
1136:
1129:
1126:
1122:sitosterolemia
1109:
1106:
1086:
1085:
1082:
1081:
1076:
1066:
1065:
1059:
1058:
1055:
1054:
1052:
1050:
1043:
1042:
1035:
1028:
1024:
1023:
1020:
1019:
1009:
1008:
1002:
999:
998:
988:
987:
981:
977:
976:
973:
972:
962:
961:
955:
952:
951:
941:
940:
934:
930:
929:
926:
925:
917:
916:
910:
907:
906:
898:
897:
891:
885:
884:
881:
880:
872:
871:
865:
862:
861:
853:
852:
846:
840:
839:
836:
835:
827:
826:
820:
817:
816:
808:
807:
801:
795:
794:
789:
784:
780:
779:
769:
768:
765:
764:
753:
752:
750:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
693:
691:
687:
686:
684:
683:
678:
673:
668:
663:
658:
653:
648:
642:
640:
636:
635:
633:
632:
627:
622:
617:
612:
607:
602:
597:
592:
586:
584:
580:
579:
569:
568:
565:
564:
561:
560:
552:
551:
540:
534:
533:
530:
529:
521:
520:
517:
516:
514:
513:
509:
505:
501:
497:
493:
489:
485:
481:
477:
473:
470:
469:
458:
455:
454:
452:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
414:jejunal mucosa
411:
408:
407:
395:
394:
386:
375:
369:
368:
365:RNA expression
357:
356:
353:
352:
344:
340:
339:
331:
328:
323:
317:
316:
307:
300:
294:
290:
289:
284:
278:
277:
269:
268:
256:
255:
252:
251:
243:
239:
238:
230:
227:
222:
216:
215:
206:
199:
193:
189:
188:
181:
175:
174:
166:
165:
153:
152:
109:
105:
104:
96:
88:
87:
83:
82:
79:
78:
75:
74:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3263:
3252:
3249:
3247:
3244:
3242:
3239:
3238:
3236:
3229:
3218:
3215:
3213:
3210:
3208:
3205:
3204:
3202:
3200:
3194:
3188:
3185:
3183:
3179:
3175:
3172:
3170:
3167:
3165:
3162:
3160:
3157:
3155:
3152:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3120:
3117:
3116:
3115:
3111:
3110:
3107:
3103:
3102:
3100:
3098:
3094:
3088:
3085:
3083:
3080:
3078:
3075:
3074:
3072:
3070:
3066:
3060:
3057:
3055:
3052:
3050:
3047:
3046:
3044:
3042:
3037:
3029:
3026:
3025:
3024:
3021:
3019:
3016:
3014:
3011:
3009:
3006:
3002:
2999:
2997:
2994:
2992:
2989:
2987:
2984:
2983:
2981:
2979:
2976:
2972:
2969:
2967:
2964:
2962:
2959:
2957:
2954:
2953:
2951:
2950:
2948:
2946:
2942:
2937:
2927:
2924:
2922:
2919:
2917:
2914:
2911:
2908:
2906:
2903:
2901:
2897:
2893:
2889:
2887:
2884:
2882:
2878:
2874:
2873:
2871:
2866:
2862:
2857:
2853:
2846:
2841:
2839:
2834:
2832:
2827:
2826:
2823:
2813:
2812:
2805:
2798:
2794:
2790:
2787:
2785:
2782:
2780:
2777:
2775:
2772:
2771:
2769:
2765:
2759:
2756:
2754:
2751:
2750:
2748:
2744:
2738:
2735:
2734:
2732:
2728:
2722:
2719:
2717:
2714:
2712:
2709:
2707:
2704:
2703:
2701:
2697:
2691:
2688:
2686:
2683:
2681:
2678:
2675:
2671:
2667:
2664:
2662:
2659:
2657:
2654:
2652:
2649:
2647:
2644:
2642:
2639:
2637:
2634:
2632:
2629:
2628:
2626:
2622:
2616:
2613:
2611:
2608:
2606:
2603:
2601:
2598:
2596:
2593:
2591:
2588:
2585:
2582:
2580:
2576:
2573:
2571:
2568:
2567:
2565:
2561:
2555:
2552:
2550:
2547:
2545:
2542:
2540:
2537:
2535:
2532:
2530:
2527:
2525:
2522:
2520:
2517:
2516:
2514:
2510:
2505:
2501:
2498:
2494:
2490:
2483:
2478:
2476:
2471:
2469:
2464:
2463:
2460:
2456:
2455:
2453:
2452:public domain
2449:
2439:
2434:
2432:
2427:
2425:
2420:
2419:
2413:
2411:
2407:
2403:
2398:
2395:
2391:
2383:
2379:
2378:
2373:
2372:
2367:
2364:
2360:
2357:
2356:
2352:
2345:
2341:
2336:
2331:
2327:
2323:
2319:
2314:
2310:
2306:
2301:
2296:
2292:
2288:
2284:
2279:
2275:
2271:
2266:
2261:
2257:
2253:
2249:
2244:
2240:
2236:
2231:
2226:
2222:
2218:
2214:
2209:
2205:
2201:
2196:
2191:
2187:
2183:
2180:(5): 671–80.
2179:
2175:
2171:
2166:
2162:
2158:
2153:
2148:
2144:
2140:
2137:(5): 659–69.
2136:
2132:
2128:
2123:
2119:
2115:
2111:
2107:
2104:(2): 276–82.
2103:
2099:
2093:
2089:
2085:
2081:
2077:
2073:
2069:
2065:
2061:
2056:
2052:
2048:
2043:
2038:
2034:
2030:
2027:(4): 565–78.
2026:
2022:
2018:
2013:
2009:
2005:
2001:
1997:
1994:(2): 178–80.
1993:
1989:
1984:
1980:
1976:
1972:
1968:
1963:
1958:
1955:(4): 359–60.
1954:
1950:
1946:
1941:
1937:
1933:
1929:
1925:
1921:
1917:
1913:
1909:
1905:
1900:
1896:
1892:
1887:
1882:
1878:
1877:10.1038/83799
1874:
1870:
1866:
1862:
1857:
1853:
1849:
1844:
1839:
1835:
1831:
1828:(5): 1041–4.
1827:
1823:
1819:
1814:
1810:
1806:
1801:
1796:
1792:
1788:
1784:
1779:
1778:
1773:
1765:
1759:
1757:
1753:
1748:
1744:
1739:
1734:
1730:
1726:
1723:(2): 278–90.
1722:
1718:
1714:
1707:
1704:
1699:
1695:
1691:
1687:
1683:
1679:
1675:
1671:
1663:
1660:
1655:
1651:
1645:
1642:
1637:
1633:
1627:
1624:
1620:
1616:
1611:
1609:
1607:
1603:
1599:
1595:
1590:
1588:
1586:
1582:
1576:
1572:
1569:
1568:
1564:
1554:
1547:
1544:
1537:
1532:
1524:
1462:
1150:
1135:
1134:
1127:
1125:
1123:
1119:
1115:
1107:
1105:
1103:
1100:
1096:
1092:
1080:
1075:
1071:
1067:
1064:
1060:
1053:
1051:
1048:
1044:
1040:
1036:
1033:
1029:
1025:
1018:
1016:
1010:
1006:
1003:
997:
995:
989:
985:
982:
978:
971:
969:
963:
959:
956:
950:
948:
942:
938:
935:
933:RefSeq (mRNA)
931:
924:
923:
918:
914:
911:
905:
904:
899:
895:
892:
890:
886:
879:
878:
873:
869:
866:
860:
859:
854:
850:
847:
845:
841:
834:
833:
828:
824:
821:
815:
814:
809:
805:
802:
800:
796:
793:
790:
788:
785:
781:
778:
774:
770:
763:
759:
754:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
713:
710:
708:
705:
703:
700:
698:
695:
694:
692:
689:
688:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
647:
644:
643:
641:
638:
637:
631:
628:
626:
623:
621:
618:
616:
613:
611:
608:
606:
603:
601:
598:
596:
593:
591:
588:
587:
585:
582:
581:
578:
577:Gene ontology
574:
570:
558:
553:
549:
544:
541:
539:
535:
527:
522:
511:
507:
503:
499:
495:
491:
487:
483:
479:
475:
474:
471:
467:
462:
459:
449:
445:
441:
437:
433:
429:
425:
421:
417:
413:
412:
409:
405:
400:
397:
396:
393:
391:
387:
385:
384:
380:
379:
376:
374:
370:
366:
362:
358:
350:
345:
341:
337:
332:
322:
318:
311:
304:
298:
291:
283:
279:
275:
270:
266:
261:
257:
249:
244:
240:
236:
231:
221:
217:
210:
203:
197:
190:
186:
180:
176:
172:
167:
163:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
106:
101:
94:
89:
84:
73:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
3227:
3211:
3197:ATP-binding
2890:delivery of
2875:delivery of
2808:
2792:
2445:
2444:
2410:expanding it
2399:
2376:
2370:
2325:
2321:
2290:
2286:
2258:(4): 653–6.
2255:
2251:
2220:
2216:
2177:
2173:
2134:
2130:
2101:
2097:
2063:
2059:
2024:
2020:
1991:
1987:
1952:
1948:
1911:
1907:
1871:(1): 79–83.
1868:
1864:
1825:
1821:
1790:
1786:
1720:
1716:
1706:
1673:
1669:
1662:
1653:
1644:
1635:
1626:
1546:
1132:
1131:
1111:
1098:
1090:
1089:
1012:
991:
965:
944:
920:
901:
875:
856:
830:
811:
791:
786:
388:
381:
108:External IDs
67:
2881:Chylomicron
2865:Lipoprotein
2856:lipoprotein
605:ATP binding
508:Paneth cell
430:gallbladder
347:84,990,439
334:84,965,662
246:43,838,865
233:43,812,472
86:Identifiers
3235:Categories
2066:(2): 151.
1621:, May 2017
1600:, May 2017
1577:References
512:left colon
392:(ortholog)
129:HomoloGene
2809:see also
1015:NP_114090
994:NP_071881
968:NM_031884
947:NM_022436
777:Orthologs
702:excretion
137:GeneCards
2789:Sterolin
2344:15611112
2309:15121760
2274:14703505
2239:14504269
2204:12208868
2161:12208867
2118:12150943
2088:23157539
2080:12124998
2051:11907139
2008:11855938
1979:10011192
1971:11668628
1936:23238025
1928:11435688
1895:11138003
1809:11590207
1747:11452359
1698:11099417
1617:–
1596:–
1565:See also
1108:Function
1063:Wikidata
756:Sources:
651:membrane
484:duodenum
422:duodenum
3041:enzymes
2042:1815568
1886:1350991
1852:9727073
1738:1201544
1678:Bibcode
1670:Science
1619:Ensembl
1598:Ensembl
1142:[[File:
1095:protein
889:UniProt
844:Ensembl
783:Species
762:QuickGO
480:jejunum
367:pattern
125:1351659
93:Aliases
3187:LRPAP1
3106:SCARB1
2912:sd LDL
2909:lb LDL
2852:Lipids
2504:TC 3A1
2368:Human
2365:(MeSH)
2342:
2307:
2272:
2237:
2202:
2195:151111
2192:
2159:
2152:151110
2149:
2116:
2086:
2078:
2049:
2039:
2006:
1977:
1969:
1934:
1926:
1893:
1883:
1850:
1843:508970
1840:
1807:
1745:
1735:
1696:
1049:search
1047:PubMed
922:Q99PE8
903:Q9H222
799:Entrez
538:BioGPS
450:kidney
117:605459
3217:ABCG8
3212:ABCG5
3207:ABCA1
3180:LDL:
3174:LRP12
3169:LRP11
3164:LRP10
3149:LRP5L
3124:LRP1B
3112:IDL:
3104:HDL:
2982:APOC
2952:APOA
2916:Lp(a)
2400:This
2377:ABCG5
2371:ABCG5
2084:S2CID
1975:S2CID
1932:S2CID
1454:]
1118:ABCG8
1099:ABCG5
1093:is a
832:27409
813:64240
792:Mouse
787:Human
758:Amigo
488:ileum
434:gonad
390:Mouse
383:Human
330:Start
265:Mouse
229:Start
162:Human
141:ABCG5
133:31909
100:ABCG5
22:ABCG5
3182:LDLR
3159:LRP8
3154:LRP6
3144:LRP5
3139:LRP4
3134:LRP3
3129:LRP2
3119:LRP1
3087:PLTP
3082:MTTP
3077:CETP
3054:LIPC
3049:LCAT
3028:SAA1
3018:APOH
3013:APOE
3008:APOD
2978:APOB
2894:and
2886:VLDL
2666:C8-9
2575:B2-3
2406:stub
2340:PMID
2305:PMID
2270:PMID
2235:PMID
2200:PMID
2157:PMID
2114:PMID
2076:PMID
2047:PMID
2004:PMID
1967:PMID
1924:PMID
1891:PMID
1848:PMID
1805:PMID
1743:PMID
1694:PMID
1536:edit
1523:edit
1102:gene
373:Bgee
321:Band
282:Chr.
225:2p21
220:Band
179:Chr.
113:OMIM
70:5DO7
51:RCSB
48:PDBe
3114:LRP
3059:LPL
3023:SAA
2921:HDL
2905:LDL
2900:IDL
2877:TGs
2690:C13
2685:C11
2680:C10
2615:B11
2554:A13
2549:A12
2330:doi
2326:280
2295:doi
2260:doi
2225:doi
2221:278
2190:PMC
2182:doi
2178:110
2147:PMC
2139:doi
2135:110
2106:doi
2102:295
2068:doi
2037:PMC
2029:doi
1996:doi
1957:doi
1916:doi
1881:PMC
1873:doi
1838:PMC
1830:doi
1826:102
1795:doi
1733:PMC
1725:doi
1686:doi
1674:290
343:End
242:End
145:OMA
121:MGI
41:PDB
3237::
2898::
2896:CE
2879::
2854::
2797:G8
2795:,
2793:G5
2784:G4
2779:G2
2774:G1
2758:F2
2753:F1
2737:E1
2721:D4
2716:D3
2711:D2
2706:D1
2674:C9
2672:,
2670:C8
2661:C7
2656:C6
2651:C5
2646:C4
2641:C3
2636:C2
2631:C1
2610:B9
2605:B7
2600:B6
2595:B5
2590:B4
2584:B3
2579:B2
2570:B1
2544:A8
2539:A7
2534:A4
2529:A3
2524:A2
2519:A1
2495::
2491:,
2338:.
2324:.
2320:.
2303:.
2291:45
2289:.
2285:.
2268:.
2256:45
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2250:.
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2198:.
2188:.
2176:.
2172:.
2155:.
2145:.
2133:.
2129:.
2112:.
2100:.
2082:.
2074:.
2064:20
2062:.
2045:.
2035:.
2025:43
2023:.
2019:.
2002:.
1992:75
1990:.
1973:.
1965:.
1953:18
1951:.
1947:.
1930:.
1922:.
1912:92
1910:.
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1879:.
1869:27
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1791:42
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1721:69
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1634:.
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1525:]]
1124:.
1104:.
760:/
349:bp
336:bp
248:bp
235:bp
143:;
139::
135:;
131::
127:;
123::
119:;
115::
3001:4
2996:3
2991:2
2986:1
2971:5
2966:4
2961:2
2956:1
2892:C
2844:e
2837:t
2830:v
2799:)
2791:(
2767:G
2746:F
2730:E
2699:D
2676:)
2668:(
2624:C
2586:)
2577:(
2563:B
2512:A
2506:)
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2481:e
2474:t
2467:v
2454:.
2437:e
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2423:v
2412:.
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2311:.
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2241:.
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2206:.
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2163:.
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2120:.
2108::
2090:.
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2053:.
2031::
2010:.
1998::
1981:.
1959::
1938:.
1918::
1897:.
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1854:.
1832::
1811:.
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1766:.
1749:.
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1700:.
1688::
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1656:.
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1434:]
1429:]
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1394:]
1389:]
1384:]
1379:]
1374:]
1369:]
1364:]
1359:]
1354:]
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1344:]
1339:]
1334:]
1329:]
1324:]
1319:]
1314:]
1309:]
1304:]
1299:]
1294:]
1289:]
1284:]
1279:]
1274:]
1269:]
1264:]
1259:]
1254:]
1249:]
1244:]
1239:]
1234:]
1229:]
1224:]
1219:]
1214:]
1209:]
267:)
164:)
147::
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