259:
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According to the FDA-approved prescribing information leaflet, "Common adverse events include inoculation site signs and symptoms, lymphadenitis, and constitutional symptoms, such as malaise, fatigue, fever, myalgia, and headache." These reactions are less frequent in people being revaccinated than
401:
stainless steel needle. The needle is dipped into the vaccine solution and used to prick the skin several times in the upper arm. The vaccinia virus will begin to grow at the injection site. It will cause a localized infection, with a red itchy sore produced at the vaccination site within three to
781:
418:
No known contraindications exist to receiving the vaccine in case of an outbreak emergency. Furthermore, it is recommended that the vaccine should be given to pregnant women who have been exposed to smallpox. "Because the risk of maternal serious illness or death, prematurity, miscarriage, or
410:
Administration of ACAM2000 poses risks and may cause side effects. Most people who have taken the vaccine only report mild reactions. Reactions may include a sore arm, fever, and body aches. Some people may have more serious side effects, including effects that may be life-threatening.
353:
According to the US FDA, "The approval and availability of this second-generation smallpox vaccine in the
Strategic National Stockpile (SNS) enhances the emergency preparedness of the United States against the use of smallpox as a dangerous
402:
four days. If the infection occurs, that is an indication that the vaccine was successful. Ultimately, the sore turns into a blister and then dries up. A scab forms and then falls off in the third week, leaving a small scar behind.
373:
virus, which is sufficiently closely related to smallpox to provide immunity, but the ACAM2000 vaccine cannot cause smallpox because it does not contain the smallpox virus. Other vaccines containing live viruses include
782:"Emergent Biosolutions' ACAM2000, (Smallpox and Mpox (Vaccinia) Vaccine, Live) Receives U.S. FDA Approval for Mpox Indication; Public Health Mpox Outbreak Continues Across Africa & Other Regions"
317:
were isolated from 3,000 doses of Dryvax and found to exhibit significant variation in virulence. The strain with the most similar virulence to the overall Dryvax mixture was selected and grown in
419:
stillbirth from a smallpox infection are greater than the risk of the vaccination, smallpox vaccine is recommended and should be offered to pregnant women in case of an outbreak emergency."
137:
313:
ACAM2000 is a vaccine developed by
Acambis, which was acquired by Sanofi Pasteur in 2008, before selling the smallpox vaccine to Emergent Biosolutions in 2017. Six strains of
1965:
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for active immunization against smallpox disease for individuals determined to be at high risk for smallpox infection. It is also indicated for the active prevention of
647:
1108:
997:
75:
1148:
1143:
839:
809:
333:
910:
549:"ACAM2000 clonal Vero cell culture vaccinia virus (New York City Board of Health strain)--a second-generation smallpox vaccine for biological defense"
329:. The United States ordered over 200 million doses of ACAM2000 in 1999–2001 for its stockpile, and production is ongoing to replace expired vaccine.
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1545:
1158:
2016:
1944:
1550:
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1113:
742:
1992:
1329:
1299:
932:
1404:
1971:
941:
1555:
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1384:
1334:
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2099:
1255:
658:
1448:
1153:
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901:
748:
523:
486:
347:
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cells to make the ACAM1000 vaccine. After a successful Phase I trial of ACAM1000, the virus was passaged three times in
217:
2033:
112:
2114:
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1007:
990:
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517:
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1703:
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343:(FDA) approved ACAM2000 in August 2007. By February 2008, it replaced Dryvax for all smallpox vaccinations.
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2002:
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for people determined to be at high risk for smallpox infection. ACAM2000 is a live replicating
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Monath TP, Caldwell JR, Mundt W, Fusco J, Johnson CS, Buller M, et al. (October 2004).
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448:"ACAM2000 (smallpox- vaccinia vaccine, live injection, powder, lyophilized, for solution"
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2027:
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688:"ACAM2000: the new smallpox vaccine for United States Strategic National Stockpile"
598:"ACAM2000: the new smallpox vaccine for United States Strategic National Stockpile"
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In August 2024, ACAM2000 was approved for mpox prevention in the United States.
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disease in individuals determined to be at high risk for mpox infection.
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As of 2010, there were over 200 million doses manufactured for the US
332:
Emergent
Biosolutions developed ACAM2000 under a contract with the US
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This article incorporates text from this source, which is in the
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302:
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43:
914:
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102:
893:"Medication Guide Smallpox (Vaccinia) Vaccine, Live ACAM2000"
784:(Press release). Emergent Biosolutions. 29 August 2024
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to develop ACAM2000, which entered mass production at
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442:
440:
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1980:
1919:
1851:
1742:
1714:
1681:
1350:
1181:
1174:
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1021:
973:
743:"ACAM2000 (Smallpox Vaccine) Questions and Answers"
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122:
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74:
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59:
49:
35:
28:
737:
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454:. U.S. National Library of Medicine. 21 March 2018
1966:Cedillo v. Secretary of Health and Human Services
512:
510:
508:
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415:those receiving the vaccine for the first time.
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473:
471:
469:
926:
8:
553:International Journal of Infectious Diseases
111:
21:
1178:
933:
919:
911:
840:Centers for Disease Control and Prevention
810:Centers for Disease Control and Prevention
369:The ACAM2000 vaccine is produced from the
334:Centers for Disease Control and Prevention
713:
703:
623:
613:
572:
225:
2057:
864:"Smallpox vaccine Use During Pregnancy"
681:
679:
428:
205:
20:
84:
7:
692:Drug Design, Development and Therapy
602:Drug Design, Development and Therapy
397:The vaccine is administered using a
149:
245:
1993:Eradication of infectious diseases
1750:Androvax (androstenedione albumin)
14:
1583:Respiratory syncytial virus (RSV)
281:. It provides protection against
2072:
2060:
1972:Alternative vaccination schedule
942:Artificial induction of immunity
762:
686:Nalca A, Zumbrun EE (May 2010).
596:Nalca A, Zumbrun EE (May 2010).
2095:Healthcare in the United States
528:(Press release). 30 August 2024
1804:Ovandrotone albumin (Fecundin)
518:"FDA Roundup: August 30, 2024"
1:
1335:Group B streptococcal disease
1154:Vaccines for Children Program
902:Food and Drug Administration
749:Food and Drug Administration
524:Food and Drug Administration
487:Food and Drug Administration
348:Strategic National Stockpile
341:Food and Drug Administration
2136:
792:– via GlobeNewswire.
565:10.1016/j.ijid.2004.09.002
365:Administration of ACAM2000
2011:
834:"Smallpox Vaccine Safety"
804:"Smallpox Vaccine Basics"
1330:Clostridioides difficile
1593:Tick-borne encephalitis
262:Smallpox vaccine needle
2003:List of vaccine topics
998:Mathematical modelling
263:
2100:History of immunology
1998:Vaccinate Your Family
1449:Japanese encephalitis
655:Emergent Biosolutions
279:Emergent Biosolutions
261:
1881:John Franklin Enders
559:(Suppl 2): S31–S44.
2105:Infectious diseases
1062:Virus-like particle
986:Vaccine ingredients
30:Vaccine description
25:
2038:Never to phase III
1837:Hexavalent vaccine
1651:Epstein–Barr virus
1546:Oxford–AstraZeneca
1234:NmVac4-A/C/Y/W-135
705:10.2147/dddt.s3687
615:10.2147/dddt.s3687
264:
2115:Smallpox vaccines
2048:
2047:
1960:Vaccines and SIDS
1847:
1846:
1621:Hepatitis A and B
1597:Varicella zoster
1054:Subunit/component
664:on 14 August 2018
356:biological weapon
256:
255:
180:
105:
2127:
2077:
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2065:
2064:
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1939:MMR autism fraud
1886:Maurice Hilleman
1871:Hilary Koprowski
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657:. Archived from
652:
648:"About ACAM2000"
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638:
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627:
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491:. 29 August 2024
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277:manufactured by
271:smallpox vaccine
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115:
104:
101:
88:
26:
24:
16:Smallpox vaccine
2135:
2134:
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2126:
2125:
2124:
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2071:
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2049:
2044:
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2028:Clinical trials
2007:
1976:
1915:
1891:Stanley Plotkin
1853:
1843:
1755:Cancer vaccines
1738:
1732:Schistosomiasis
1710:
1704:Trypanosomiasis
1677:
1641:Cytomegalovirus
1551:Pfizer–BioNTech
1346:
1170:
1119:Vaccine wastage
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1017:
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2019:
2013:
2012:
2009:
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2000:
1995:
1990:
1984:
1982:
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1969:
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1952:
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1906:Katalin KarikĂł
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1561:Sinopharm BIBP
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1511:Bharat Biotech
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1136:
1134:Vaccine injury
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1097:
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1094:Administration
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1031:
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1016:
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1005:
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993:
983:
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886:External links
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844:. 13 July 2017
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814:. 13 July 2017
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3:
2:
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1861:Edward Jenner
1859:
1858:
1856:
1850:
1838:
1835:
1833:
1832:DTwP-HepB-Hib
1830:
1828:
1827:DTaP-IPV-HepB
1825:
1823:
1820:
1819:
1818:combination:
1817:
1815:
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1807:
1805:
1802:
1800:
1797:
1793:
1790:
1786:
1783:
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1773:
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1716:Helminthiasis
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1617:combination:
1616:
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1611:
1607:
1604:
1602:
1599:
1598:
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1594:
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1589:
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1554:
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1547:
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1537:
1534:
1532:
1529:
1527:
1524:
1522:
1519:
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1514:
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1509:
1507:
1504:
1503:
1502:
1499:
1497:
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1492:
1489:
1487:
1484:
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1477:
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1472:
1471:
1470:
1467:
1465:
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1457:
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1349:
1341:
1338:
1336:
1333:
1331:
1328:
1327:
1325:
1321:
1318:
1316:
1315:DPT/DTwP/DTaP
1313:
1312:
1311:combination:
1310:
1308:
1305:
1301:
1298:
1296:
1293:
1292:
1291:
1288:
1284:
1281:
1280:
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1249:
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1235:
1232:
1230:
1227:
1226:
1225:
1224:Meningococcus
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1988:Epidemiology
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1822:DTaP-IPV/Hib
1613:Yellow fever
1526:EpiVacCorona
1278:Tuberculosis
1251:Pneumococcal
1219:Lyme disease
1047:Heterologous
946:Immunization
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275:mpox vaccine
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168:Legal status
162:Legal status
131:Percutaneous
94:License data
51:Vaccine type
18:
2024:from market
1920:Controversy
1854:researchers
1770:Hepatitis B
1656:Hepatitis C
1601:Chicken pox
1427:Hepatitis E
1422:Hepatitis B
1417:Hepatitis A
1363:Chikungunya
1340:Shigellosis
1194:Brucellosis
1080:Therapeutic
1034:Inactivated
974:Development
962:Inoculation
954:Vaccination
873:8 September
848:8 September
818:8 September
788:1 September
756:8 September
668:8 September
532:1 September
495:1 September
192:Identifiers
66:Trade names
2089:Categories
1955:Thiomersal
1901:Paul Offit
1876:Jonas Salk
1852:Inventors/
1723:research:
1700:research:
1637:research:
1566:Skycovione
1556:Sanofi–GSK
1501:SARS-CoV-2
1412:Hantavirus
1373:rVSV-ZEBOV
1358:Adenovirus
1326:research:
1204:Diphtheria
1042:Attenuated
481:"ACAM2000"
458:10 January
423:References
399:bifurcated
392:chickenpox
323:Vero cells
227:4SV59689SK
55:Live virus
2034:Phase III
2022:Withdrawn
1950:Pox party
1760:ALVAC-CEA
1682:Protozoan
1571:Sputnik V
1521:CoronaVac
1491:Rotavirus
1389:Pandemrix
1241:Pertussis
1182:Bacterial
1066:Synthetic
1029:Conjugate
981:Adjuvants
958:Infection
868:Drugs.com
698:: 71–79.
608:: 71–79.
299:indicated
289:vaccine.
124:Routes of
80:Drugs.com
2120:Vaccines
2110:Smallpox
2067:Medicine
1792:Prostvac
1785:Gardasil
1780:Cervarix
1727:Hookworm
1606:Shingles
1588:Smallpox
1506:Corbevax
1442:Gardasil
1437:Cervarix
1175:Vaccines
1129:Schedule
1100:Global:
1008:Timeline
950:Vaccines
724:20531961
634:20531961
583:15491873
452:DailyMed
371:vaccinia
315:vaccinia
283:smallpox
267:ACAM2000
198:DrugBank
138:ATC code
113:Acam2000
108:DailyMed
86:Acam2000
70:Acam2000
40:Smallpox
23:ACAM2000
2079:Viruses
2053:Portals
1981:Related
1927:General
1689:Malaria
1576:Valneva
1541:Novavax
1536:Moderna
1531:Janssen
1516:CanSino
1496:Rubella
1454:Measles
1320:Td/Tdap
1290:Typhoid
1273:Tetanus
1268:Q fever
1199:Cholera
1189:Anthrax
1058:Peptide
1022:Classes
1003:Storage
715:2880337
625:2880337
574:7110559
384:rubella
376:measles
339:The US
336:(CDC).
309:History
273:and an
207:DB15497
154:)
148: (
146:J07BX01
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2017:WHO-EM
1937:Lancet
1814:TA-NIC
1799:NicVAX
1646:Dengue
1486:Rabies
1307:Typhus
1246:Plague
1124:Policy
1085:Toxoid
1013:Trials
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327:Baxter
247:D05295
183:â„ž-only
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36:Target
1945:NCVIA
1809:TA-CD
1743:Other
1694:RTS,S
1474:Sabin
1469:Polio
1464:Mumps
1368:Ebola
1351:Viral
1300:ViCPS
1295:Ty21a
1229:MeNZB
1159:VAERS
1109:NITAG
1038:Live
904:(FDA)
900:U.S.
896:(PDF)
842:(CDC)
838:U.S.
812:(CDC)
808:U.S.
751:(FDA)
747:U.S.
662:(PDF)
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522:U.S.
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485:U.S.
406:Risks
388:polio
380:mumps
319:MRC-5
269:is a
1671:Zika
1631:MMRV
1479:Salk
1459:Mpox
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1075:mRNA
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820:2018
790:2024
758:2018
720:PMID
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630:PMID
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390:and
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238:KEGG
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1775:HPV
1765:BCG
1666:HIV
1626:MMR
1432:HPV
1380:Flu
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1071:DNA
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