60:
620:
597:
2696:
2648:
4910:
2734:
4895:
494:
519:
4880:
878:
871:
626:
525:
1688:
271:
1878:
1828:
cleft and binds to ACh receptors on the post-synaptic membrane, relaying the signal from the nerve. AChE is concentrated in the synaptic cleft, where it terminates the signal transmission by hydrolyzing ACh. The liberated choline is taken up again by the pre-synaptic neuron and ACh is synthesized by
2006:
In mammals, acetylcholinesterase is encoded by a single AChE gene while some invertebrates have multiple acetylcholinesterase genes. Note higher vertebrates also encode a closely related paralog BCHE (butyrylcholinesterase) with 50% amino acid identity to ACHE. Diversity in the transcribed products
1800:
In humans, AChE is a cholinergic enzyme involved in the hydrolysis of the neurotransmitter acetylcholine (ACh) into its constituents, choline, and acetate. Overall, in mammals, AChE is primarily involved in the termination of impulse transmission at cholinergic synapses by rapid hydrolysis of the
4177:
Ehrlich G, Viegas-Pequignot E, Ginzberg D, Sindel L, Soreq H, Zakut H (1992). "Mapping the human acetylcholinesterase gene to chromosome 7q22 by fluorescent in situ hybridization coupled with selective PCR amplification from a somatic hybrid cell panel and chromosome-sorted DNA libraries".
297:
1801:
neurotransmitter acetylcholine. In non-vertebrates, AChE plays a similar role in nerve conduction processes at the neuromuscular junction. It is usually located in the membranes of these animals and controls ionic currents in excitable membranes.
1979:
AChE is found in many types of conducting tissue: nerve and muscle, central and peripheral tissues, motor and sensory fibers, and cholinergic and noncholinergic fibers. The activity of AChE is higher in motor neurons than in sensory neurons.
1811:
Some marine fungi have been found to produce compounds that inhibit AChE. However, the specific role and mechanisms of AChE in fungi are not as well-studied as in mammals. The presence and role of AChE in bacteria is not well-documented.
6498:
4909:
1901:(OP), esters of phosphoric acid, are a class of irreversible AChE inhibitors. Cleavage of OP by AChE leaves a phosphoryl group in the esteratic site, which is slow to be hydrolyzed (on the order of days) and can become
3786:
Millard CB, Kryger G, Ordentlich A, Greenblatt HM, Harel M, Raves ML, et al. (June 1999). "Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level".
4894:
2528:
Radić Z, Gibney G, Kawamoto S, MacPhee-Quigley K, Bongiorno C, Taylor P (October 1992). "Expression of recombinant acetylcholinesterase in a baculovirus system: kinetic properties of glutamate 199 mutants".
6491:
2434:
Sussman JL, Harel M, Frolow F, Oefner C, Goldman A, Toker L, et al. (August 1991). "Atomic structure of acetylcholinesterase from
Torpedo californica: a prototypic acetylcholine-binding protein".
1933:). Reversible inhibitors occupy the esteratic site for short periods of time (seconds to minutes) and are used to treat of a range of central nervous system diseases. Tetrahydroaminoacridine (THA) and
4349:"The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant"
2663:"Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket"
4950:
6932:
4000:
Sussman JL, Harel M, Frolow F, Oefner C, Goldman A, Toker L, et al. (1991). "Atomic structure of acetylcholinesterase from
Torpedo californica: a prototypic acetylcholine-binding protein".
6978:
6484:
1723:
of AChE comprises two subsites—the anionic site and the esteratic subsite. The structure and mechanism of action of AChE have been elucidated from the crystal structure of the enzyme.
8166:
8171:
1808:(tomato) identified 87 SlAChE genes containing GDSL lipase/acylhydrolase domain. The study also showed up-and down-regulation of SlAChE genes under salinity stress condition.
1738:
residues that line a gorge leading to the active site. All 14 amino acids in the aromatic gorge are highly conserved across different species. Among the aromatic amino acids,
2042:
which stands for
Proline Rich Membrane anchor to form symmetric form. In either case, the ColQ or PRiMA anchor serves to maintain the enzyme in the intercellular junction,
1777:. Moreover, the triad is of opposite chirality to that of other proteases. The hydrolysis reaction of the carboxyl ester leads to the formation of an acyl-enzyme and free
4943:
633:
532:
4879:
4601:"Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase"
2566:"Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase"
225:
4482:"Coamplification of human acetylcholinesterase and butyrylcholinesterase genes in blood cells: correlation with various leukemias and abnormal megakaryocytopoiesis"
2026:
The major form of acetylcholinesterase found in brain, muscle, and other tissues, known as is the hydrophilic species, which forms disulfide-linked oligomers with
2150:
Exposure to acetylcholinesterase inhibitors is one of several studied explanations for the chronic cognitive symptoms veterans displayed after returning from the
1804:
In plants, the biological functions of AChE are less clear, and its existence has been recognized by indirect evidence of its activity. For instance, a study on
426:, AChE, acetylhydrolase, acetylcholinesterase (Yt blood group), ACEE, ARN-YT, acetylcholinesterase (Cartwright blood group), true cholinesterase (dated synonym)
244:
4435:
Chhajlani V, Derr D, Earles B, Schmell E, August T (1989). "Purification and partial amino acid sequence analysis of human erythrocyte acetylcholinesterase".
3751:
Dori A, Ifergane G, Saar-Levy T, Bersudsky M, Mor I, Soreq H, et al. (2007). "Readthrough acetylcholinesterase in inflammation-associated neuropathies".
4936:
2162:-ECD, researchers at the University of South Carolina School of Medicine determined PB, when combined with a stress element can lead to cognitive responses.
2131:
are those that do not irreversibly bond to and deactivate AChE. Drugs that reversibly inhibit acetylcholine esterase are being explored as treatments for
2607:"The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors"
1261:
2974:"Acetylcholinesterase activities in marine snail (Cronia contracta) as a biomarker of neurotoxic contaminants along the Goa coast, West coast of India"
3036:"Acetylcholinesterase inhibitors and antioxidants mining from marine fungi: Bioassays, bioactivity coupled LC–MS/MS analyses and molecular networking"
455:
2485:
Sussman JL, Harel M, Silman I (June 1993). "Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs".
1242:
7123:
5562:
4740:
3863:"Pyridostigmine bromide and stress interact to impact immune function, cholinergic neurochemistry and behavior in a rat model of Gulf War Illness"
1964:, which may limit inflammation in the brain by silencing the expression of this protein and allowing ACh to act in an anti-inflammatory capacity.
6593:
3651:
Johnson G, Moore SW (2012). "Why has butyrylcholinesterase been retained? Structural and functional diversification in a duplicated gene. 2012".
3270:
5809:
5088:
3231:
4859:
3845:
3377:
3352:
3319:
3282:
3241:
3169:
3136:
2356:
2345:
Purves D, Augustine GJ, Fitzpatrick D, Katz LC, LaMantia AS, McNamara JO, et al. (2001). "Chapter 6. Neurotransmitters: Acetylcholine".
2326:
2299:
2099:
sp. and mice although it is hypothesized in other species. It is thought to be involved in the stress response and, possibly, inflammation.
4918:: STRUCTURE OF THE TETRAMERIZATION DOMAIN OF ACETYLCHOLINESTERASE: FOUR-FOLD INTERACTION OF A WWW MOTIF WITH A LEFT-HANDED POLYPROLINE HELIX
8192:
5723:
4634:
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
2281:
8045:
7958:
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5818:
5619:
5369:
5265:
5231:
5217:
5074:
1529:
619:
8014:
6818:
5667:
3310:
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5567:
2876:
4533:
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4384:"Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure"
1844:
drug disrupts this process by acting as a cholinergic neurotransmitter that is impervious to acetylcholinesterase's lysing action.
596:
6603:
7098:
5226:
4737:
ATSDR Case
Studies in Environmental Medicine: Cholinesterase Inhibitors, Including Insecticides and Chemical Warfare Nerve Agents
4244:"Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding"
2015:
associations of catalytic and structural subunits. There are three known forms: T (tail), R (read through), and H (hydrophobic).
1592:
237:
5885:
5773:
3737:
2268:
2247:
1925:, esters of N-methyl carbamic acid, are AChE inhibitors that hydrolyze in hours and have been used for medical purposes (e.g.,
1862:
AChE lead to persistence of high concentrations of ACh within synapses, leading to increased cholinergic signaling within the
6637:
5694:
5604:
5557:
2122:
1853:
164:
6363:
3076:
2264:
188:
6563:
1994:. Acetylcholinesterase exists in multiple molecular forms, which possess similar catalytic properties, but differ in their
518:
493:
294:
7313:
6116:
6057:
5108:
5023:
4804:
3528:"Histochemical localization of cholinesterase in the amphibian spinal cord and alterations following ventral root section"
3483:
Massoulié J, Pezzementi L, Bon S, Krejci E, Vallette FM (July 1993). "Molecular and cellular biology of cholinesterases".
2901:"Identification of Acetylcholinesterase Like Gene Family and Its Expression Under Salinity Stress in Solanum lycopersicum"
6613:
2243:
1734:. The cationic substrates are not bound by a negatively charged amino acid in the anionic site, but by interaction of 14
8161:
7900:
6514:
6161:
5728:
5718:
5182:
4903:: CRYSTAL STRUCTURE OF MUTANT E202Q OF HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH GREEN MAMBA VENOM PEPTIDE FASCICULIN-II
4785:
2034:-containing structural subunits. In the neuromuscular junctions AChE expresses in asymmetric form which associates with
435:
6598:
59:
7108:
6121:
6013:
5638:
2939:
4692:
Massoulié J, Pezzementi L, Bon S, Krejci E, Vallette FM (1993). "Molecular and
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7771:
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4971:
1716:
6348:
6573:
6558:
6542:
6464:
6451:
6438:
6425:
6412:
6399:
6386:
5969:
5915:
5875:
5834:
5738:
5577:
5545:
5431:
5395:
5303:
5083:
4852:
2073:
1834:
1668:
625:
524:
42:
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3567:
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7538:
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6255:
5623:
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5386:
4209:"Evidence that the antigens of the Yt blood group system are located on human erythrocyte acetylcholinesterase"
1306:
443:
182:
75:
3612:"Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism"
4562:
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2372:
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bromide (PB) as protection from nerve agent weapons. Studying acetylcholine levels using microdialysis and
1797:
AChE is found in many biological species, including humans and other mammals, non-vertebrates, and plants.
8197:
6048:
5687:
5212:
2733:
2132:
1938:
1871:
1863:
1648:
3233:
Anticholinesterase Drugs and
Cholinergic Agonists", in Pharmacology and Physiology in Anesthetic Practice
7906:
7827:
6281:
6200:
5983:
5880:
5672:
5633:
5497:
5419:
5331:
5257:
4314:"Gene structure of mammalian acetylcholinesterase. Alternative exons dictate tissue-specific expression"
3912:"Inhibitory Effects of Cannabinoids on Acetylcholinesterase and Butyrylcholinesterase Enzyme Activities"
249:
31:
8071:
8067:
8063:
8059:
8036:
8032:
6353:
157:
4759:
3288:
7756:
7103:
6583:
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6001:
5996:
5929:
5589:
5069:
4845:
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4444:
4395:
4009:
3703:
3047:
2985:
2760:
2494:
2443:
2008:
1968:
1805:
507:
92:
6476:
3395:"MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase"
3247:
7917:
7883:
7817:
7746:
7563:
7513:
7038:
6838:
6696:
6317:
6021:
5991:
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87:
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185:
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2920:
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2012:
1946:
1867:
467:
109:
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8086:
8028:
8005:
7994:
7548:
7533:
7408:
7358:
7308:
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6988:
5955:
5900:
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5743:
5462:
5113:
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4709:
4680:
4651:
4622:
4579:
4550:
4521:
4460:
4423:
4370:
4335:
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3584:
3549:
3500:
3465:
3436:"A molecular link between the active component of marijuana and Alzheimer's disease pathology"
3416:
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3335:
Drachman DB, Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS, et al. (1998).
3315:
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3109:
3001:
2973:
2872:
2788:
2749:"Gorge Motions of Acetylcholinesterase Revealed by Microsecond Molecular Dynamics Simulations"
2684:
2661:
Ordentlich A, Barak D, Kronman C, Flashner Y, Leitner M, Segall Y, et al. (August 1993).
2636:
2587:
2546:
2510:
2459:
2416:
2352:
2322:
2136:
1954:
1821:
1753:
The esteratic subsite, where acetylcholine is hydrolyzed to acetate and choline, contains the
1660:
415:
287:
176:
7293:
6781:
3861:
Macht VA, Woodruff JL, Maissy ES, Grillo CA, Wilson MA, Fadel JR, et al. (August 2019).
8120:
8101:
7797:
7598:
7593:
7588:
7583:
7578:
7573:
7568:
7488:
7373:
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6031:
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5511:
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3711:
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3623:
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2815:
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2502:
2451:
2408:
2381:
2081:
1961:
1918:
1898:
1859:
1770:
1743:
1731:
1652:
1632:
877:
870:
712:
643:
587:
542:
7248:
3185:
2564:
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8055:
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7938:
7933:
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7028:
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6998:
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6240:
6133:
5947:
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5761:
5521:
5399:
5269:
5028:
3104:
2201:
1754:
1687:
687:
463:
145:
4279:"The human gene encoding acetylcholinesterase is located on the long arm of chromosome 7"
3434:
Eubanks LM, Rogers CJ, Beuscher AE, Koob GF, Olson AJ, Dickerson TJ, et al. (2006).
64:
Acetylcholinesterase catalyzes the hydrolysis of acetylcholine to acetate ion and choline
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5453:
5426:
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3983:
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3938:
3911:
3887:
3862:
3628:
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3435:
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3209:
3161:
2783:
2748:
2631:
2606:
2220:
2196:
2155:
2109:
2107:
The nomenclatural variations of ACHE and of cholinesterases generally are discussed at
2058:
1988:
1984:
1950:
1841:
1612:
270:
220:
80:
38:
4676:
4516:
4481:
4365:
4348:
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4243:
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919:
200:
8186:
7726:
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7298:
7173:
6828:
6507:
6286:
6245:
5847:
5756:
5506:
5284:
5139:
4826:
4705:
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3095:
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2710:
2506:
2191:
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1708:
1624:
906:
195:
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3512:
3013:
2834:
2471:
8082:
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6711:
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5905:
5628:
5549:
5249:
4074:
2181:
1942:
1906:
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6882:
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4888:: HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH FASCICULIN-II, GLYCOSYLATED PROTEIN
4575:
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3035:
2972:
Gaitonde D, Sarkar A, Kaisary S, Silva CD, Dias C, Rao DP, et al. (2006).
2916:
2853:
2773:
2346:
788:
8135:
8131:
7863:
7853:
7848:
7761:
7736:
7696:
7691:
7681:
7666:
7607:
7602:
7413:
7273:
7258:
7228:
7203:
7178:
7133:
7128:
7118:
7088:
7058:
6922:
6912:
6857:
6852:
6823:
6800:
6766:
6731:
6716:
6681:
6656:
6510:
6126:
5196:
3878:
3764:
3715:
2997:
2605:
Ariel N, Ordentlich A, Barak D, Bino T, Velan B, Shafferman A (October 1998).
2206:
2062:
1995:
1922:
1902:
1830:
1739:
1700:
604:
501:
451:
4124:
2726:
1746:
results in a 3000-fold decrease in reactivity. The gorge is approximately 20
7974:
7858:
7807:
7716:
7711:
7701:
7543:
7478:
7473:
7463:
7418:
7388:
7383:
7368:
7353:
7323:
7288:
7278:
7183:
7063:
7053:
7043:
7013:
7008:
7003:
6927:
6902:
6867:
6796:
6771:
6741:
6701:
6651:
6433:
6407:
6039:
5838:
5751:
5378:
5204:
5200:
4984:
4980:
4506:
4408:
4021:
3269:
Taylor P, Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG (1996).
2455:
2144:
1934:
1910:
1890:
1886:
1785:
attack by a water molecule, assisted by the histidine 440 group, liberating
1774:
1766:
1762:
1712:
1704:
1696:
1676:
1620:
1206:
848:
726:
671:
658:
570:
557:
459:
4617:
4600:
4480:
Lapidot-Lifson Y, Prody CA, Ginzberg D, Meytes D, Zakut H, Soreq H (1989).
4161:
4132:
4103:
4066:
3947:
3896:
3808:
3772:
3723:
3672:
3588:
3553:
3469:
3420:
3005:
2792:
2582:
2565:
4780:
AChE bivalent inhibitors AChE_bivalent_inhibitors AChE bivalent inhibitors
4713:
4684:
4655:
4626:
4583:
4554:
4525:
4464:
4427:
4374:
4339:
4304:
4269:
4234:
4199:
4029:
3992:
3637:
3580:
3504:
3370:
Autonomic and Somatic Nervous Systems in Netter's Illustrated Pharmacology
3152:
English BA, Webster AA (2012). "Acetylcholinesterase and its Inhibitors".
3113:
2688:
2640:
2591:
2550:
2514:
2463:
2420:
1576:
8141:
7843:
7776:
7731:
7661:
7629:
7528:
7508:
7498:
7363:
7283:
7213:
7198:
7083:
7078:
6983:
6917:
6862:
6786:
6736:
6666:
6646:
6084:
6079:
6074:
5895:
5530:
5382:
5245:
5046:
5042:
2399:
Taylor P, Radić Z (1994). "The cholinesterases: from genes to proteins".
2151:
2027:
1930:
1747:
1735:
1560:
1351:
1332:
4546:
2542:
2385:
7878:
7786:
7751:
7523:
7423:
7393:
7378:
7328:
7223:
7168:
7163:
7158:
7153:
7148:
7143:
7138:
7113:
7068:
6962:
6957:
6877:
6872:
6746:
6091:
6069:
6064:
5682:
5280:
4831:
4821:
2140:
2069:
1991:
1825:
1778:
1628:
1318:
1273:
152:
133:
4095:
3928:
3800:
3451:
2622:
1571:
974:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
352:
348:
344:
340:
336:
332:
328:
324:
320:
316:
7403:
7193:
6952:
6947:
6942:
6937:
6751:
6525:
6446:
6216:
6111:
6044:
5937:
5535:
5443:
4959:
4058:
3967:"Modes of attachment of acetylcholinesterase to the surface membrane"
3186:"National Pesticide Information Center-Diazinon Technical Fact Sheet"
3034:
Nie Y, Yang W, Liu Y, Yang J, Lei X, Gerwick WH, et al. (2020).
2039:
1758:
1616:
1544:
1228:
232:
128:
116:
104:
1967:
It has also been shown that the main active ingredient in cannabis,
17:
7781:
7503:
7493:
7343:
7238:
6588:
6420:
6053:
5804:
5800:
4791:
2031:
1914:
1876:
1727:
1686:
2057:
The other, alternatively spliced form expressed primarily in the
1707:
activity—each molecule of AChE degrades about 5,000 molecules of
1191:
1187:
5785:
5662:
5655:
5599:
5594:
5261:
3312:
Goodman & Gilman's The pharmacological basis of therapeutics
2159:
2043:
2038:
or subunit. In the central nervous system it is associated with
2035:
1769:
334. These three amino acids are similar to the triad in other
439:
140:
6480:
6189:
5351:
4932:
4841:
4837:
3210:"Clinical Application: Acetylcholine and Alzheimer's Disease"
2711:"Acetylcholinesterase: Mechanism of Catalysis and Inhibition"
2317:
Katzung BG (2001). "Introduction to Autonomic Pharmacology".
886:
6933:
Octamethylene-bis(5-dimethylcarbamoxyisoquinolinium bromide)
4816:
Overview of all the structural information available in the
2940:"Acetylcholinesterase :A Versatile Enzyme of Nervous System"
8046:
7959:
6979:
2-Ethoxycarbonyl-1-methylvinyl cyclohexyl methylphosphonate
2715:
Current Medicinal Chemistry - Central Nervous System Agents
8015:
6185:
4277:
Getman DK, Eubanks JH, Camp S, Evans GA, Taylor P (1992).
1773:
except that the glutamate is the third member rather than
1730:
of acetylcholine as well as other cationic substrates and
3738:"Entrez Gene: ACHE acetylcholinesterase (Yt blood group)"
1726:
The anionic subsite accommodates the positive quaternary
1092:
negative regulation of synaptic transmission, cholinergic
695:
4312:
Li Y, Camp S, Rachinsky TL, Getman D, Taylor P (1992).
2046:
for the neuromuscular junction and PRiMA for synapses.
1824:, ACh is released from the presynaptic neuron into the
3131:(4th ed.). Sinauer Associates. pp. 121–122.
1971:, is a competitive inhibitor of acetylcholinesterase.
1905:
bound. Irreversible AChE inhibitors have been used in
1667:
of enzymes. It is the primary target of inhibition by
3830:
Julien RM, Advokat CD, Comaty JE (October 12, 2007).
3029:
3027:
3025:
3023:
2351:(2nd ed.). Sunderland (MA): Sinauer Associates.
2007:
from the sole mammalian gene arises from alternative
1998:
assembly and mode of attachment to the cell surface.
1885:
Irreversible inhibitors of AChE may lead to muscular
860:
4113:
Current Drug Targets. CNS and Neurological Disorders
3910:
Puopolo T, Liu C, Ma H, Seeram NP (April 19, 2022).
2967:
2965:
8100:
8004:
7987:
7957:
7916:
7899:
7826:
6622:
6541:
6524:
6372:
6336:
6305:
6274:
6223:
6142:
6030:
5982:
5968:
5946:
5928:
5914:
5894:
5833:
5737:
5576:
5544:
5394:
5312:
5292:
5279:
5244:
5195:
5171:
5151:
5138:
5097:
5058:
5041:
5012:
4992:
4979:
4970:
3343:(14 ed.). The McCraw-Hill Companies. pp.
1711:(ACh) per second, approaching the limit allowed by
1501:
1452:
1422:
1369:
243:
231:
219:
214:
194:
175:
163:
151:
139:
127:
115:
103:
98:
86:
74:
69:
52:
3336:
2260:
2258:
2256:
2239:
2237:
2235:
1937:are FDA-approved to improve cognitive function in
6543:
5673:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
2835:"Molecular Architecture and Biological Reactions"
1177:positive regulation of cold-induced thermogenesis
1172:acetylcholine catabolic process in synaptic cleft
642:
541:
3836:(Eleventh ed.). Worth Publishers. pp.
3610:Bartels CF, Zelinski T, Lockridge O (May 1993).
1987:membranes, where different forms constitute the
3277:. THe McGraw-Hill Companies. pp. 161–174.
2095:The third type has, so far, only been found in
7888:Many of the other AChE inhibitors listed above
3271:"5: Autonomic Pharmacology: Cholinergic Drugs"
2265:GRCm38: Ensembl release 89: ENSMUSG00000023328
1960:An endogenous inhibitor of AChE in neurons is
1913:) and nerve gases for chemical warfare (e.g.,
7828:
6492:
6201:
5363:
4944:
4853:
2938:Tripathi A, Srivastava UC (January 2, 2010).
2321:(8th ed.). McGraw-Hill. pp. 75–91.
1659:type, where its activity serves to terminate
8:
8167:Muscarinic acetylcholine receptor modulators
6624:
2401:Annual Review of Pharmacology and Toxicology
8172:Nicotinic acetylcholine receptor modulators
8051:Tooltip Vesicle-associated membrane protein
7964:Tooltip Vesicular acetylcholine transporter
7918:
2871:. San Francisco: W.H. Freeman. p. 14.
2244:GRCh38: Ensembl release 89: ENSG00000087085
1097:amyloid precursor protein metabolic process
30:"ACHE" redirects here. For other uses, see
8020:Tooltip Synaptosomal-associated protein 25
8001:
7913:
6538:
6499:
6485:
6477:
6208:
6194:
6186:
5979:
5925:
5911:
5370:
5356:
5348:
5289:
5148:
5055:
4989:
4976:
4951:
4937:
4929:
4860:
4846:
4838:
3339:Harrison's Principles of Internal Medicine
2084:(PI) moieties added post-translationally.
1983:Acetylcholinesterase is also found on the
1449:
1366:
1202:
902:
761:Skeletal muscle tissue of rectus abdominis
683:
582:
479:
305:
211:
58:
4616:
4515:
4505:
4417:
4407:
4364:
4329:
4294:
4259:
4224:
3982:
3937:
3927:
3886:
3627:
3543:
3459:
3410:
3103:
3059:
2894:
2892:
2890:
2888:
2782:
2772:
2678:
2630:
2581:
4786:Acetylcholinesterase: A gorge-ous enzyme
4770:AChE_inhibitors_and_substrates_(Part_II)
4207:Spring FA, Gardner B, Anstee DJ (1992).
3275:The Pharmacologial Basis of Therapeutics
1157:phosphatidylcholine biosynthetic process
1142:positive regulation of protein secretion
7124:Dimethyl 4-(methylthio)phenyl phosphate
5563:Ubiquitin carboxy-terminal hydrolase L1
4875:
4741:Department of Health and Human Services
3372:. Elsevier Health Science. p. 43.
3314:. New York: McGraw-Hill. p. 1634.
2231:
2110:Cholinesterase § Types and nomenclature
5089:Phenylethanolamine N-methyltransferase
3154:Primer on the Autonomic Nervous System
2899:Sarangle Y, Bamel K, Purty RS (2023).
2747:Cheng S, Song W, Yuan X, Xu Y (2017).
1945:is also used to treat Alzheimer's and
260:
49:
7314:Methylfluorophosphonylcholine (MFPCh)
6564:2-(α-Naphthoyl)ethyltrimethylammonium
6143:either deoxy- or ribo-
1132:retina development in camera-type eye
1087:neurotransmitter biosynthetic process
647:
608:
603:
546:
505:
500:
7:
5724:Protein serine/threonine phosphatase
4830:(Human Acetylcholinesterase) at the
3040:Marine Life Science & Technology
2340:
2338:
8111:
6614:N,N-Dimethylaminoethylchloroacetate
5825:Cyclic nucleotide phosphodiesterase
5819:Clostridium perfringens alpha toxin
5620:Tartrate-resistant acid phosphatase
5232:Acetylserotonin O-methyltransferase
2413:10.1146/annurev.pa.34.040194.001433
2127:For acetylcholine esterase (AChE),
1703:choline esters. It has a very high
940:carboxylic ester hydrolase activity
5668:Pyruvate dehydrogenase phosphatase
3984:10.1111/j.1432-1033.1987.tb13662.x
3162:10.1016/b978-0-12-386525-0.00132-3
3084:Trends in Pharmacological Sciences
2905:Journal of Plant Growth Regulation
1789:and regenerating the free enzyme.
1781:. Then, the acyl-enzyme undergoes
1498:
1419:
1342:
1323:
1297:
1278:
1252:
1233:
1117:neurotransmitter catabolic process
865:
807:central gray substance of midbrain
783:
721:
700:
27:Primary cholinesterase in the body
25:
6548:Tooltip Choline acetyltransferase
5568:4-hydroxybenzoyl-CoA thioesterase
3916:Medical Cannabis and Cannabinoids
2956:10.5214/ans.0972.7531.2008.150403
2820:10.5214/ans.0972.7531.2008.150403
2154:. Soldiers were dosed with AChEI
2139:, among others. Examples include
920:protein homodimerization activity
7608:Fasciculins (green mamba toxins)
7099:Dicyclohexyl phosphorofluoridate
5227:Aralkylamine N-acetyltransferase
4908:
4893:
4878:
3569:Journal of Comparative Neurology
2732:
2694:
2646:
1162:regulation of receptor recycling
876:
869:
631:
624:
618:
595:
530:
523:
517:
492:
269:
7539:Tetraethyl pyrophosphate (TEPP)
7264:Hexaethyl tetraphosphate (HETP)
5886:N-acetylglucosamine-6-sulfatase
5774:Sphingomyelin phosphodiesterase
2842:Chemical & Engineering News
2319:Basic and Clinical Pharmacology
1881:Mechanism of Inhibitors of AChE
1107:acetylcholine catabolic process
1031:perinuclear region of cytoplasm
6609:N,N-Dimethylaminoethylacrylate
5695:Inositol-phosphate phosphatase
5558:Palmitoyl protein thioesterase
4760:AChE_inhibitors_and_substrates
3965:Silman I, Futerman AH (1988).
3156:. Elsevier. pp. 631–633.
3105:11858/00-001M-0000-0013-0E8C-5
2869:Enzyme structure and mechanism
2123:Acetylcholinesterase inhibitor
1854:Acetylcholinesterase inhibitor
1750:deep and five angstroms wide.
1683:Enzyme structure and mechanism
1599:; EC 3.1.1.7; systematic name
1036:anchored component of membrane
887:More reference expression data
849:More reference expression data
741:right hemisphere of cerebellum
1:
8162:Receptor/signaling modulators
7934:Hemicholinium-3 (hemicholine)
7833:Tooltip Butyrylcholinesterase
6058:RNA-induced silencing complex
5109:Catechol-O-methyl transferase
5024:Histamine N-methyltransferase
4677:10.1016/s0079-6123(08)62392-4
4366:10.1016/S0021-9258(18)54380-5
4331:10.1016/S0021-9258(18)54466-5
4261:10.1016/S0021-9258(19)37091-7
4226:10.1182/blood.V80.8.2136.2136
3867:Brain, Behavior, and Immunity
2680:10.1016/S0021-9258(19)85305-X
1601:acetylcholine acetylhydrolase
1167:cell population proliferation
980:acetylcholinesterase activity
616:
515:
6629:Tooltip Acetylcholinesterase
6162:Serratia marcescens nuclease
5729:Dual-specificity phosphatase
5719:Protein tyrosine phosphatase
5183:4-aminobutyrate transaminase
4706:10.1016/0301-0082(93)90040-Y
4648:10.1016/0378-1119(94)90802-8
4457:10.1016/0014-5793(89)81352-3
4192:10.1016/0888-7543(92)90037-S
3665:10.1016/j.neuint.2012.06.016
3497:10.1016/0301-0082(93)90040-Y
3412:10.1016/j.immuni.2009.09.019
3096:10.1016/0165-6147(90)90034-6
2507:10.1016/0009-2797(93)90042-W
8193:Genes on human chromosome 7
7923:Tooltip Choline transporter
7869:Profenamine (ethopropazine)
7109:Diisopropyl fluorophosphate
6574:4-(1-Naphthylvinyl)pyridine
6559:1-(-Benzoylethyl)pyridinium
5639:Fructose 1,6-bisphosphatase
4047:Nature Reviews Neuroscience
3526:Chacko LW, Cerf JA (1960).
2065:, and contains a cleavable
1893:constriction, and death by
831:nucleus of stria terminalis
8219:
7772:Dimethylcarbamoyl fluoride
6579:Acetylseco hemicholinium-3
4809:gene details page in the
4576:10.1002/jcb.1982.240180406
4154:10.1016/j.tins.2006.02.005
3061:10.1007/s42995-020-00065-9
2917:10.1007/s00344-023-11152-3
2854:10.1021/cen-v024n010.p1375
2774:10.1038/s41598-017-03088-y
2120:
1851:
1669:organophosphorus compounds
1112:nervous system development
36:
29:
8154:
6364:Michaelis–Menten kinetics
5876:Galactosamine-6 sulfatase
5432:6-phosphogluconolactonase
5304:Choline acetyltransferase
5222:-amino acid decarboxylase
5084:Dopamine beta-hydroxylase
5079:-amino acid decarboxylase
4873:
3879:10.1016/j.bbi.2019.04.015
3765:10.1016/j.lfs.2007.02.011
3716:10.1016/j.cbi.2008.04.039
2998:10.1007/s10646-006-0075-3
2300:"Mouse PubMed Reference:"
2282:"Human PubMed Reference:"
2076:site. It associates with
1953:bromide is used to treat
1835:choline acetyltransferase
1744:substitution with alanine
1575:
1570:
1566:
1559:
1543:
1537:Chr 5: 137.29 – 137.29 Mb
1524:
1505:
1476:
1445:
1426:
1393:
1362:
1349:
1345:
1330:
1326:
1317:
1304:
1300:
1285:
1281:
1272:
1259:
1255:
1240:
1236:
1227:
1212:
1205:
1201:
1185:
935:serine hydrolase activity
905:
901:
884:
868:
859:
846:
795:
786:
733:
724:
694:
686:
682:
665:
652:
615:
594:
585:
581:
564:
551:
514:
491:
482:
478:
433:
430:
420:
413:
408:
313:
308:
291:
286:
281:
277:
268:
263:
210:
57:
43:Choline acetyltransferase
7642:Methanesulfonyl fluoride
6256:Diffusion-limited enzyme
5624:Purple acid phosphatases
4125:10.2174/1568007033482869
3485:Progress in Neurobiology
2727:10.2174/1568015013358536
2061:tissues, differs at the
1691:AChe mechanism of action
1631:esters that function as
1530:Chr 7: 100.89 – 100.9 Mb
1082:receptor internalization
1077:muscle organ development
955:protein self-association
37:Not to be confused with
6819:+glycopyrronium bromide
5163:Glutamate decarboxylase
5004:Histidine decarboxylase
4507:10.1073/pnas.86.12.4715
4409:10.1073/pnas.87.24.9688
4022:10.1126/science.1678899
3833:A Primer of Drug Action
2944:Annals of Neurosciences
2808:Annals of Neurosciences
2456:10.1126/science.1678899
1872:neuromuscular junctions
1742:84 is critical and its
1665:carboxylesterase family
1649:neuromuscular junctions
1102:protein tetramerization
950:cholinesterase activity
6569:3-Chloro-4-stillbazole
6049:Microprocessor complex
5688:Beta-propeller phytase
5213:Tryptophan hydroxylase
4618:10.1074/jbc.270.5.2082
2583:10.1074/jbc.270.5.2082
2177:Δ-Tetrahydrocannabinol
1882:
1864:central nervous system
1833:through the action of
1757:of three amino acids:
1692:
1647:It is found at mainly
1615:in the body. It is an
1147:osteoblast development
1056:neuromuscular junction
757:triceps brachii muscle
6349:Eadie–Hofstee diagram
6282:Allosteric regulation
5984:Endodeoxyribonuclease
5881:Iduronate-2-sulfatase
5634:Glucose 6-phosphatase
5420:Butyrylcholinesterase
5332:Butyrylcholinesterase
5258:Nitric oxide synthase
3581:10.1002/cne.901000108
3230:Stoelting RK (1999).
3075:Whittaker VP (1990).
2129:reversible inhibitors
1929:for the treatment of
1880:
1858:Drugs or toxins that
1690:
1661:synaptic transmission
1643:O = choline + acetate
930:acetylcholine binding
8130:Atracotoxins (e.g.,
7757:Tetrahydrocannabinol
7104:Diisopropylphosphate
6359:Lineweaver–Burk plot
6167:Micrococcal nuclease
6002:Deoxyribonuclease IV
5997:Deoxyribonuclease II
5930:Exodeoxyribonuclease
5590:Alkaline phosphatase
5415:Acetylcholinesterase
5328:Acetylcholinesterase
5070:Tyrosine hydroxylase
4803:genome location and
4792:Acetylcholinesterase
4750:Acetylcholinesterase
3696:Chem. Biol. Interact
3236:. Lippincott-Raven.
2487:Chem. Biol. Interact
1969:tetrahydrocannabinol
1806:Solanum lycopersicum
1663:. It belongs to the
1589:Acetylcholinesterase
1137:response to wounding
1016:extracellular region
945:amyloid-beta binding
827:striatum of neuraxis
749:gastrocnemius muscle
649:5 G2|5 76.32 cM
610:Chromosome 5 (mouse)
508:Chromosome 7 (human)
309:List of PDB id codes
282:Available structures
53:acetylcholinesterase
8116:Tooltip Latrophilin
7818:Trimedoxime bromide
7747:Stercuronium iodide
7564:Tricresyl phosphate
7039:Chlorpyrifos-methyl
6022:UvrABC endonuclease
5992:Deoxyribonuclease I
5715:Protein phosphatase
5651:Protein phosphatase
5449:Bile salt-dependent
5437:PAF acetylhydrolase
4811:UCSC Genome Browser
4547:10.1021/bi00349a019
4498:1989PNAS...86.4715L
4449:1989FEBSL.247..279C
4400:1990PNAS...87.9688S
4014:1991Sci...253..872S
3708:2008CBI...175...30M
3052:2020MLST....2..386N
2990:2006Ecotx..15..353G
2765:2017NatSR...7.3219C
2543:10.1021/bi00155a032
2499:1993CBI....87..187S
2448:1991Sci...253..872S
2386:10.1021/cr00081a005
2187:Cannabigerolic acid
2133:Alzheimer's disease
1939:Alzheimer's disease
1816:Biological function
1051:extracellular space
835:inferior colliculus
815:superior colliculus
7635:Onchidella binneyi
6977:Organophosphates:
6318:Enzyme superfamily
6251:Enzyme promiscuity
6155:Mung bean nuclease
6014:Restriction enzyme
6007:Restriction enzyme
3759:(24–25): 2369–74.
3532:Journal of Anatomy
2833:Pauling L (1946).
2753:Scientific Reports
2013:post-translational
1947:Lewy body dementia
1883:
1693:
1307:ENSMUSG00000023328
1070:Biological process
989:Cellular component
970:hydrolase activity
913:Molecular function
765:right frontal lobe
8180:
8179:
8150:
8149:
7998:
7983:
7982:
7910:
7895:
7894:
7534:Tetrachlorvinphos
7409:Pirimiphos-methyl
7359:Oxydemeton-methyl
7309:Methyl phenkapton
6535:
6474:
6473:
6183:
6182:
6179:
6178:
6175:
6174:
5964:
5963:
5956:Oligonucleotidase
5901:deoxyribonuclease
5869:Steroid sulfatase
5744:Phosphodiesterase
5473:Hormone-sensitive
5345:
5344:
5341:
5340:
5240:
5239:
5221:
5191:
5190:
5134:
5133:
5114:Monoamine oxidase
5078:
5037:
5036:
4964:neurotransmission
4926:
4925:
4283:Am. J. Hum. Genet
4096:10.1021/ar010025i
3929:10.1159/000524086
3847:978-1-4292-0679-2
3801:10.1021/bi982678l
3616:Am. J. Hum. Genet
3452:10.1021/mp060066m
3379:978-1-929007-60-8
3368:Raffe RB (2004).
3354:978-0-07-020291-7
3321:978-0-07-146804-6
3284:978-0-07-146804-6
3243:978-0-7817-5469-9
3171:978-0-12-386525-0
3138:978-0-87893-697-7
2867:Fersht A (1985).
2848:(10): 1375–1377.
2623:10.1042/bj3350095
2358:978-0-87893-697-7
2328:978-0-07-160405-5
2167:Phytocannabinoids
2137:myasthenia gravis
1955:myasthenia gravis
1868:autonomic ganglia
1848:Disease relevance
1822:neurotransmission
1653:chemical synapses
1639:acetylcholine + H
1633:neurotransmitters
1623:the breakdown of
1611:, is the primary
1603:), also known as
1586:
1585:
1582:
1581:
1555:
1554:
1520:
1519:
1495:
1494:
1441:
1440:
1416:
1415:
1358:
1357:
1339:
1338:
1313:
1312:
1294:
1293:
1268:
1267:
1249:
1248:
1197:
1196:
1061:basement membrane
897:
896:
893:
892:
855:
854:
842:
841:
823:cerebellar cortex
799:medulla oblongata
780:
779:
753:nucleus accumbens
678:
677:
577:
576:
404:
403:
400:
399:
292:Ortholog search:
259:
258:
255:
254:
158:metabolic pathway
16:(Redirected from
8210:
8117:
8113:
8052:
8048:
8021:
8017:
8002:
7992:
7965:
7961:
7924:
7920:
7914:
7904:
7834:
7830:
7798:Asoxime chloride
7374:Parathion-methyl
7074:Demeton-S-methyl
6630:
6626:
6549:
6545:
6539:
6529:
6501:
6494:
6487:
6478:
6354:Hanes–Woolf plot
6297:Enzyme activator
6292:Enzyme inhibitor
6266:Enzyme catalysis
6210:
6203:
6196:
6187:
6032:Endoribonuclease
6018:
6012:
5980:
5926:
5912:
5612:Acid phosphatase
5493:Monoacylglycerol
5403:ester hydrolases
5372:
5365:
5358:
5349:
5317:
5297:
5290:
5219:
5176:
5156:
5149:
5102:
5076:
5063:
5056:
5017:
4997:
4990:
4977:
4953:
4946:
4939:
4930:
4912:
4897:
4882:
4862:
4855:
4848:
4839:
4725:
4688:
4659:
4630:
4620:
4595:
4564:J. Cell. Biochem
4558:
4529:
4519:
4509:
4476:
4431:
4421:
4411:
4378:
4368:
4359:(35): 23977–84.
4343:
4333:
4324:(34): 23083–90.
4308:
4298:
4273:
4263:
4238:
4228:
4203:
4173:
4136:
4107:
4078:
4059:10.1038/35067589
4041:
3996:
3986:
3952:
3951:
3941:
3931:
3907:
3901:
3900:
3890:
3858:
3852:
3851:
3827:
3821:
3820:
3783:
3777:
3776:
3748:
3742:
3741:
3734:
3728:
3727:
3691:
3685:
3684:
3648:
3642:
3641:
3631:
3607:
3601:
3600:
3564:
3558:
3557:
3547:
3523:
3517:
3516:
3480:
3474:
3473:
3463:
3431:
3425:
3424:
3414:
3390:
3384:
3383:
3365:
3359:
3358:
3342:
3332:
3326:
3325:
3307:
3301:
3300:
3298:
3296:
3291:on March 4, 2016
3287:. Archived from
3266:
3260:
3259:
3257:
3255:
3250:on March 3, 2016
3246:. Archived from
3227:
3221:
3220:
3218:
3216:
3206:
3200:
3199:
3197:
3195:
3190:
3182:
3176:
3175:
3149:
3143:
3142:
3124:
3118:
3117:
3107:
3081:
3072:
3066:
3065:
3063:
3031:
3018:
3017:
2969:
2960:
2959:
2935:
2929:
2928:
2896:
2883:
2882:
2864:
2858:
2857:
2839:
2830:
2824:
2823:
2803:
2797:
2796:
2786:
2776:
2744:
2738:
2737:
2736:
2730:
2709:Tougu V (2001).
2706:
2700:
2699:
2698:
2692:
2682:
2673:(23): 17083–95.
2658:
2652:
2651:
2650:
2644:
2634:
2602:
2596:
2595:
2585:
2561:
2555:
2554:
2525:
2519:
2518:
2482:
2476:
2475:
2431:
2425:
2424:
2396:
2390:
2389:
2374:Chemical Reviews
2369:
2363:
2362:
2342:
2333:
2332:
2314:
2308:
2307:
2296:
2290:
2289:
2278:
2272:
2262:
2251:
2241:
2082:phosphoinositide
1962:Mir-132 microRNA
1899:Organophosphates
1771:serine proteases
1568:
1567:
1539:
1532:
1515:
1499:
1490:
1450:
1446:RefSeq (protein)
1436:
1420:
1411:
1367:
1343:
1324:
1298:
1279:
1253:
1234:
1203:
1152:synapse assembly
925:collagen binding
903:
889:
880:
873:
866:
851:
791:
789:Top expressed in
784:
729:
727:Top expressed in
722:
701:
684:
674:
661:
650:
635:
628:
622:
611:
599:
583:
573:
560:
549:
534:
527:
521:
510:
496:
480:
474:
472:ACHE - orthologs
425:
418:
395:
306:
300:
279:
278:
273:
261:
212:
62:
50:
21:
8218:
8217:
8213:
8212:
8211:
8209:
8208:
8207:
8183:
8182:
8181:
8176:
8146:
8115:
8096:
8056:Botulinum toxin
8050:
8025:Botulinum toxin
8019:
7991:
7979:
7963:
7953:
7939:Triethylcholine
7922:
7903:
7891:
7832:
7822:
7742:Rosmarinic acid
7509:Sulfotep (TEDP)
7179:Ethylsarin (GE)
7059:Cyclosarin (GF)
7029:Chlorfenvinphos
7019:Carbophenothion
6999:Azinphos-methyl
6628:
6618:
6584:Acryloylcholine
6547:
6528:
6520:
6505:
6475:
6470:
6382:Oxidoreductases
6368:
6344:Enzyme kinetics
6332:
6328:List of enzymes
6301:
6270:
6241:Catalytic triad
6219:
6214:
6184:
6171:
6138:
6026:
6016:
6010:
5973:
5960:
5948:Exoribonuclease
5942:
5919:
5903:
5899:
5890:
5864:Arylsulfatase L
5859:Arylsulfatase B
5854:Arylsulfatase A
5829:
5742:
5733:
5572:
5540:
5402:
5390:
5376:
5346:
5337:
5313:
5308:
5293:
5275:
5236:
5187:
5172:
5167:
5152:
5130:
5098:
5093:
5059:
5033:
5029:Diamine oxidase
5013:
5008:
4993:
4966:
4957:
4927:
4922:
4919:
4913:
4904:
4898:
4889:
4883:
4869:
4866:
4733:
4728:
4694:Prog. Brain Res
4691:
4665:Prog. Brain Res
4662:
4633:
4598:
4561:
4532:
4479:
4434:
4394:(24): 9688–92.
4381:
4346:
4311:
4276:
4254:(25): 17640–8.
4241:
4206:
4176:
4142:Trends Neurosci
4139:
4110:
4081:
4044:
4008:(5022): 872–9.
3999:
3971:Eur. J. Biochem
3964:
3960:
3958:Further reading
3955:
3909:
3908:
3904:
3860:
3859:
3855:
3848:
3829:
3828:
3824:
3785:
3784:
3780:
3750:
3749:
3745:
3736:
3735:
3731:
3693:
3692:
3688:
3650:
3649:
3645:
3609:
3608:
3604:
3566:
3565:
3561:
3538:(Pt 1): 74–81.
3525:
3524:
3520:
3482:
3481:
3477:
3433:
3432:
3428:
3392:
3391:
3387:
3380:
3367:
3366:
3362:
3355:
3334:
3333:
3329:
3322:
3309:
3308:
3304:
3294:
3292:
3285:
3268:
3267:
3263:
3253:
3251:
3244:
3229:
3228:
3224:
3214:
3212:
3208:
3207:
3203:
3193:
3191:
3188:
3184:
3183:
3179:
3172:
3151:
3150:
3146:
3139:
3126:
3125:
3121:
3079:
3074:
3073:
3069:
3033:
3032:
3021:
2971:
2970:
2963:
2937:
2936:
2932:
2898:
2897:
2886:
2879:
2866:
2865:
2861:
2837:
2832:
2831:
2827:
2805:
2804:
2800:
2746:
2745:
2741:
2731:
2708:
2707:
2703:
2693:
2660:
2659:
2655:
2645:
2604:
2603:
2599:
2563:
2562:
2558:
2527:
2526:
2522:
2493:(1–3): 187–97.
2484:
2483:
2479:
2442:(5022): 872–9.
2433:
2432:
2428:
2398:
2397:
2393:
2371:
2370:
2366:
2359:
2344:
2343:
2336:
2329:
2316:
2315:
2311:
2298:
2297:
2293:
2280:
2279:
2275:
2263:
2254:
2242:
2233:
2229:
2221:Cholinesterases
2217:
2202:Cannabichromene
2125:
2119:
2105:
2093:
2091:
2055:
2053:
2024:
2022:
2004:
1977:
1889:, convulsions,
1856:
1850:
1829:combining with
1818:
1795:
1755:catalytic triad
1685:
1642:
1627:and some other
1609:acetylhydrolase
1577:View/Edit Mouse
1572:View/Edit Human
1535:
1528:
1525:Location (UCSC)
1511:
1507:
1486:
1482:
1478:
1472:
1468:
1464:
1460:
1456:
1432:
1428:
1407:
1403:
1399:
1395:
1389:
1385:
1381:
1377:
1373:
1288:ENSG00000087085
1181:
1122:DNA replication
1065:
1006:plasma membrane
996:Golgi apparatus
984:
965:laminin binding
960:protein binding
885:
875:
874:
847:
838:
833:
829:
825:
821:
817:
813:
809:
805:
801:
787:
776:
773:caudate nucleus
771:
767:
763:
759:
755:
751:
747:
743:
739:
737:muscle of thigh
725:
669:
656:
648:
638:
637:
636:
629:
609:
586:Gene location (
568:
555:
547:
537:
536:
535:
528:
506:
483:Gene location (
434:
421:
414:
315:
293:
65:
46:
35:
28:
23:
22:
15:
12:
11:
5:
8216:
8214:
8206:
8205:
8200:
8195:
8185:
8184:
8178:
8177:
8175:
8174:
8169:
8164:
8159:
8155:
8152:
8151:
8148:
8147:
8145:
8144:
8139:
8124:
8123:
8106:
8104:
8098:
8097:
8095:
8094:
8091:Îł-bungarotoxin
8087:β-bungarotoxin
8076:
8075:
8041:
8040:
8010:
8008:
7999:
7985:
7984:
7981:
7980:
7978:
7977:
7968:
7966:
7955:
7954:
7952:
7951:
7942:
7941:
7936:
7927:
7925:
7911:
7897:
7896:
7893:
7892:
7890:
7889:
7886:
7881:
7876:
7871:
7866:
7861:
7856:
7851:
7846:
7837:
7835:
7824:
7823:
7821:
7820:
7815:
7810:
7805:
7800:
7790:
7789:
7784:
7779:
7774:
7769:
7764:
7759:
7754:
7749:
7744:
7739:
7734:
7729:
7724:
7719:
7714:
7709:
7704:
7699:
7694:
7689:
7684:
7679:
7674:
7669:
7664:
7659:
7654:
7645:
7644:
7639:
7627:
7605:
7596:
7591:
7586:
7581:
7576:
7571:
7566:
7561:
7556:
7551:
7546:
7541:
7536:
7531:
7526:
7521:
7516:
7511:
7506:
7501:
7496:
7491:
7486:
7481:
7476:
7471:
7466:
7461:
7456:
7451:
7446:
7441:
7436:
7431:
7426:
7421:
7416:
7411:
7406:
7401:
7396:
7391:
7386:
7381:
7376:
7371:
7366:
7361:
7356:
7351:
7349:Novichok agent
7346:
7341:
7336:
7331:
7326:
7321:
7316:
7311:
7306:
7301:
7296:
7291:
7286:
7281:
7276:
7271:
7269:Isofluorophate
7266:
7261:
7256:
7251:
7246:
7241:
7236:
7231:
7226:
7221:
7216:
7211:
7206:
7201:
7196:
7191:
7186:
7181:
7176:
7171:
7166:
7161:
7156:
7151:
7146:
7141:
7136:
7131:
7126:
7121:
7116:
7111:
7106:
7101:
7096:
7091:
7086:
7081:
7076:
7071:
7066:
7061:
7056:
7051:
7046:
7041:
7036:
7031:
7026:
7024:Chlorethoxyfos
7021:
7016:
7011:
7006:
7001:
6996:
6994:Azinphos-ethyl
6991:
6986:
6981:
6971:
6970:
6965:
6960:
6955:
6950:
6945:
6940:
6935:
6930:
6925:
6920:
6915:
6910:
6905:
6900:
6895:
6890:
6885:
6880:
6875:
6870:
6865:
6860:
6855:
6846:
6841:
6836:
6834:Pyridostigmine
6831:
6826:
6821:
6813:
6808:
6803:
6794:
6789:
6784:
6779:
6774:
6769:
6764:
6759:
6754:
6749:
6744:
6739:
6734:
6729:
6724:
6719:
6714:
6709:
6704:
6699:
6694:
6689:
6684:
6679:
6674:
6669:
6664:
6659:
6654:
6649:
6633:
6631:
6620:
6619:
6617:
6616:
6611:
6606:
6601:
6596:
6591:
6586:
6581:
6576:
6571:
6566:
6561:
6552:
6550:
6536:
6522:
6521:
6506:
6504:
6503:
6496:
6489:
6481:
6472:
6471:
6469:
6468:
6455:
6442:
6429:
6416:
6403:
6390:
6376:
6374:
6370:
6369:
6367:
6366:
6361:
6356:
6351:
6346:
6340:
6338:
6334:
6333:
6331:
6330:
6325:
6320:
6315:
6309:
6307:
6306:Classification
6303:
6302:
6300:
6299:
6294:
6289:
6284:
6278:
6276:
6272:
6271:
6269:
6268:
6263:
6258:
6253:
6248:
6243:
6238:
6233:
6227:
6225:
6221:
6220:
6215:
6213:
6212:
6205:
6198:
6190:
6181:
6180:
6177:
6176:
6173:
6172:
6170:
6169:
6164:
6159:
6158:
6157:
6146:
6144:
6140:
6139:
6137:
6136:
6131:
6130:
6129:
6124:
6119:
6114:
6104:
6099:
6094:
6089:
6088:
6087:
6082:
6077:
6072:
6062:
6061:
6060:
6051:
6036:
6034:
6028:
6027:
6025:
6024:
6019:
6004:
5999:
5994:
5988:
5986:
5977:
5966:
5965:
5962:
5961:
5959:
5958:
5952:
5950:
5944:
5943:
5941:
5940:
5934:
5932:
5923:
5909:
5892:
5891:
5889:
5888:
5883:
5878:
5873:
5872:
5871:
5866:
5861:
5856:
5843:
5841:
5831:
5830:
5828:
5827:
5822:
5812:
5807:
5798:
5793:
5788:
5783:
5782:
5781:
5771:
5770:
5769:
5764:
5754:
5748:
5746:
5735:
5734:
5732:
5731:
5726:
5721:
5712:
5711:
5710:
5692:
5691:
5690:
5680:
5675:
5670:
5665:
5660:
5659:
5658:
5648:
5647:
5646:
5636:
5631:
5626:
5609:
5608:
5607:
5602:
5597:
5586:
5584:
5574:
5573:
5571:
5570:
5565:
5560:
5554:
5552:
5542:
5541:
5539:
5538:
5533:
5527:
5526:
5525:
5524:
5519:
5514:
5503:
5502:
5501:
5500:
5498:Diacylglycerol
5495:
5490:
5485:
5480:
5475:
5470:
5465:
5460:
5451:
5440:
5439:
5434:
5429:
5427:Pectinesterase
5424:
5423:
5422:
5417:
5410:Cholinesterase
5406:
5404:
5392:
5391:
5377:
5375:
5374:
5367:
5360:
5352:
5343:
5342:
5339:
5338:
5336:
5335:
5324:Cholinesterase
5320:
5318:
5310:
5309:
5307:
5306:
5300:
5298:
5287:
5277:
5276:
5274:
5273:
5254:
5252:
5242:
5241:
5238:
5237:
5235:
5234:
5229:
5224:
5215:
5209:
5207:
5193:
5192:
5189:
5188:
5186:
5185:
5179:
5177:
5169:
5168:
5166:
5165:
5159:
5157:
5146:
5136:
5135:
5132:
5131:
5129:
5128:
5127:
5126:
5121:
5111:
5105:
5103:
5095:
5094:
5092:
5091:
5086:
5081:
5072:
5066:
5064:
5053:
5039:
5038:
5035:
5034:
5032:
5031:
5026:
5020:
5018:
5010:
5009:
5007:
5006:
5000:
4998:
4987:
4974:
4968:
4967:
4958:
4956:
4955:
4948:
4941:
4933:
4924:
4923:
4921:
4920:
4914:
4907:
4905:
4899:
4892:
4890:
4884:
4877:
4874:
4871:
4870:
4867:
4865:
4864:
4857:
4850:
4842:
4836:
4835:
4814:
4795:
4789:
4783:
4773:
4763:
4753:
4743:
4732:
4731:External links
4729:
4727:
4726:
4689:
4660:
4642:(1–2): 171–4.
4631:
4611:(5): 2082–91.
4596:
4559:
4530:
4492:(12): 4715–9.
4477:
4432:
4379:
4344:
4309:
4274:
4239:
4219:(8): 2136–41.
4204:
4174:
4137:
4108:
4084:Acc. Chem. Res
4079:
4053:(4): 294–302.
4042:
3997:
3977:(1–2): 11–22.
3961:
3959:
3956:
3954:
3953:
3902:
3853:
3846:
3822:
3795:(22): 7032–9.
3778:
3743:
3729:
3702:(1–3): 30–44.
3686:
3659:(5): 783–797.
3653:Neurochem. Int
3643:
3602:
3559:
3518:
3475:
3426:
3385:
3378:
3360:
3353:
3327:
3320:
3302:
3283:
3261:
3242:
3222:
3201:
3177:
3170:
3144:
3137:
3119:
3067:
3046:(4): 386–397.
3019:
2984:(4): 353–358.
2961:
2950:(4): 106–111.
2930:
2911:(3): 940–960.
2884:
2877:
2859:
2825:
2814:(4): 106–111.
2798:
2739:
2721:(2): 155–170.
2701:
2653:
2597:
2576:(5): 2082–91.
2556:
2537:(40): 9760–7.
2520:
2477:
2426:
2391:
2364:
2357:
2334:
2327:
2309:
2291:
2273:
2252:
2230:
2228:
2225:
2224:
2223:
2216:
2213:
2212:
2211:
2210:
2209:
2204:
2199:
2197:Cannabidivarin
2194:
2189:
2184:
2179:
2174:
2156:pyridostigmine
2121:Main article:
2118:
2115:
2104:
2101:
2092:
2089:
2086:
2054:
2051:
2048:
2023:
2020:
2017:
2003:
2000:
1989:Yt blood group
1985:red blood cell
1976:
1973:
1951:pyridostigmine
1852:Main article:
1849:
1846:
1842:cholinomimetic
1817:
1814:
1794:
1791:
1684:
1681:
1645:
1644:
1640:
1613:cholinesterase
1584:
1583:
1580:
1579:
1574:
1564:
1563:
1557:
1556:
1553:
1552:
1550:
1548:
1541:
1540:
1533:
1526:
1522:
1521:
1518:
1517:
1503:
1502:
1496:
1493:
1492:
1474:
1473:
1447:
1443:
1442:
1439:
1438:
1424:
1423:
1417:
1414:
1413:
1391:
1390:
1364:
1360:
1359:
1356:
1355:
1347:
1346:
1340:
1337:
1336:
1328:
1327:
1321:
1315:
1314:
1311:
1310:
1302:
1301:
1295:
1292:
1291:
1283:
1282:
1276:
1270:
1269:
1266:
1265:
1257:
1256:
1250:
1247:
1246:
1238:
1237:
1231:
1225:
1224:
1219:
1214:
1210:
1209:
1199:
1198:
1195:
1194:
1183:
1182:
1180:
1179:
1174:
1169:
1164:
1159:
1154:
1149:
1144:
1139:
1134:
1129:
1124:
1119:
1114:
1109:
1104:
1099:
1094:
1089:
1084:
1079:
1073:
1071:
1067:
1066:
1064:
1063:
1058:
1053:
1048:
1046:synaptic cleft
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
992:
990:
986:
985:
983:
982:
977:
972:
967:
962:
957:
952:
947:
942:
937:
932:
927:
922:
916:
914:
910:
909:
899:
898:
895:
894:
891:
890:
882:
881:
863:
857:
856:
853:
852:
844:
843:
840:
839:
837:
836:
832:
828:
824:
820:
816:
812:
808:
804:
800:
796:
793:
792:
781:
778:
777:
775:
774:
770:
766:
762:
758:
754:
750:
746:
742:
738:
734:
731:
730:
718:
717:
709:
698:
692:
691:
688:RNA expression
680:
679:
676:
675:
667:
663:
662:
654:
651:
646:
640:
639:
630:
623:
617:
613:
612:
607:
601:
600:
592:
591:
579:
578:
575:
574:
566:
562:
561:
553:
550:
545:
539:
538:
529:
522:
516:
512:
511:
504:
498:
497:
489:
488:
476:
475:
432:
428:
427:
419:
411:
410:
406:
405:
402:
401:
398:
397:
311:
310:
302:
301:
290:
284:
283:
275:
274:
266:
265:
257:
256:
253:
252:
247:
241:
240:
235:
229:
228:
223:
217:
216:
208:
207:
198:
192:
191:
180:
173:
172:
167:
161:
160:
155:
149:
148:
143:
137:
136:
131:
125:
124:
119:
113:
112:
107:
101:
100:
96:
95:
90:
84:
83:
78:
72:
71:
67:
66:
63:
55:
54:
39:Cholinesterase
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
8215:
8204:
8201:
8199:
8198:Acetylcholine
8196:
8194:
8191:
8190:
8188:
8173:
8170:
8168:
8165:
8163:
8160:
8157:
8156:
8153:
8143:
8140:
8137:
8133:
8129:
8126:
8125:
8122:
8119:
8114:
8108:
8107:
8105:
8103:
8099:
8092:
8088:
8084:
8083:Bungarotoxins
8081:
8078:
8077:
8073:
8069:
8065:
8061:
8057:
8054:
8053:inactivators:
8049:
8043:
8042:
8038:
8034:
8030:
8026:
8023:
8022:inactivators:
8018:
8012:
8011:
8009:
8007:
8003:
8000:
7996:
7990:
7986:
7976:
7973:
7970:
7969:
7967:
7962:
7956:
7950:
7947:
7944:
7943:
7940:
7937:
7935:
7932:
7929:
7928:
7926:
7921:
7915:
7912:
7908:
7902:
7898:
7887:
7885:
7884:ZINC-12613047
7882:
7880:
7877:
7875:
7872:
7870:
7867:
7865:
7862:
7860:
7857:
7855:
7852:
7850:
7847:
7845:
7842:
7839:
7838:
7836:
7831:
7825:
7819:
7816:
7814:
7811:
7809:
7806:
7804:
7801:
7799:
7795:
7792:
7791:
7788:
7785:
7783:
7780:
7778:
7775:
7773:
7770:
7768:
7765:
7763:
7760:
7758:
7755:
7753:
7750:
7748:
7745:
7743:
7740:
7738:
7735:
7733:
7730:
7728:
7727:Lactucopicrin
7725:
7723:
7720:
7718:
7715:
7713:
7710:
7708:
7705:
7703:
7700:
7698:
7695:
7693:
7690:
7688:
7685:
7683:
7680:
7678:
7675:
7673:
7670:
7668:
7665:
7663:
7660:
7658:
7655:
7653:
7650:
7647:
7646:
7643:
7640:
7637:
7636:
7631:
7628:
7625:
7621:
7617:
7613:
7609:
7606:
7604:
7600:
7597:
7595:
7592:
7590:
7587:
7585:
7582:
7580:
7577:
7575:
7572:
7570:
7567:
7565:
7562:
7560:
7559:Trichloronate
7557:
7555:
7552:
7550:
7547:
7545:
7542:
7540:
7537:
7535:
7532:
7530:
7527:
7525:
7522:
7520:
7517:
7515:
7512:
7510:
7507:
7505:
7502:
7500:
7497:
7495:
7492:
7490:
7487:
7485:
7482:
7480:
7477:
7475:
7472:
7470:
7467:
7465:
7462:
7460:
7457:
7455:
7452:
7450:
7447:
7445:
7442:
7440:
7437:
7435:
7432:
7430:
7427:
7425:
7422:
7420:
7417:
7415:
7412:
7410:
7407:
7405:
7402:
7400:
7397:
7395:
7392:
7390:
7387:
7385:
7382:
7380:
7377:
7375:
7372:
7370:
7367:
7365:
7362:
7360:
7357:
7355:
7352:
7350:
7347:
7345:
7342:
7340:
7337:
7335:
7334:Monocrotophos
7332:
7330:
7327:
7325:
7322:
7320:
7317:
7315:
7312:
7310:
7307:
7305:
7302:
7300:
7299:Methamidophos
7297:
7295:
7292:
7290:
7287:
7285:
7282:
7280:
7277:
7275:
7272:
7270:
7267:
7265:
7262:
7260:
7257:
7255:
7252:
7250:
7247:
7245:
7242:
7240:
7237:
7235:
7232:
7230:
7227:
7225:
7222:
7220:
7217:
7215:
7212:
7210:
7207:
7205:
7202:
7200:
7197:
7195:
7192:
7190:
7187:
7185:
7182:
7180:
7177:
7175:
7174:Echothiophate
7172:
7170:
7167:
7165:
7162:
7160:
7157:
7155:
7152:
7150:
7147:
7145:
7142:
7140:
7137:
7135:
7132:
7130:
7127:
7125:
7122:
7120:
7117:
7115:
7112:
7110:
7107:
7105:
7102:
7100:
7097:
7095:
7092:
7090:
7087:
7085:
7082:
7080:
7077:
7075:
7072:
7070:
7067:
7065:
7062:
7060:
7057:
7055:
7052:
7050:
7047:
7045:
7042:
7040:
7037:
7035:
7032:
7030:
7027:
7025:
7022:
7020:
7017:
7015:
7012:
7010:
7007:
7005:
7002:
7000:
6997:
6995:
6992:
6990:
6987:
6985:
6982:
6980:
6976:
6975:Irreversible:
6973:
6972:
6969:
6966:
6964:
6961:
6959:
6956:
6954:
6951:
6949:
6946:
6944:
6941:
6939:
6936:
6934:
6931:
6929:
6926:
6924:
6921:
6919:
6916:
6914:
6911:
6909:
6906:
6904:
6901:
6899:
6896:
6894:
6891:
6889:
6886:
6884:
6881:
6879:
6876:
6874:
6871:
6869:
6866:
6864:
6861:
6859:
6856:
6854:
6850:
6847:
6845:
6842:
6840:
6839:Quilostigmine
6837:
6835:
6832:
6830:
6829:Physostigmine
6827:
6825:
6822:
6820:
6817:
6814:
6812:
6809:
6807:
6804:
6802:
6799:; Stigmines:
6798:
6795:
6793:
6790:
6788:
6785:
6783:
6780:
6778:
6775:
6773:
6770:
6768:
6765:
6763:
6760:
6758:
6755:
6753:
6750:
6748:
6745:
6743:
6740:
6738:
6735:
6733:
6730:
6728:
6725:
6723:
6720:
6718:
6715:
6713:
6710:
6708:
6705:
6703:
6700:
6698:
6697:Chloropropham
6695:
6693:
6690:
6688:
6685:
6683:
6680:
6678:
6675:
6673:
6670:
6668:
6665:
6663:
6660:
6658:
6655:
6653:
6650:
6648:
6644:
6641:
6639:
6635:
6634:
6632:
6627:
6621:
6615:
6612:
6610:
6607:
6605:
6602:
6600:
6597:
6595:
6592:
6590:
6587:
6585:
6582:
6580:
6577:
6575:
6572:
6570:
6567:
6565:
6562:
6560:
6557:
6554:
6553:
6551:
6546:
6540:
6537:
6533:
6527:
6523:
6519:
6516:
6512:
6509:
6508:Acetylcholine
6502:
6497:
6495:
6490:
6488:
6483:
6482:
6479:
6466:
6462:
6461:
6456:
6453:
6449:
6448:
6443:
6440:
6436:
6435:
6430:
6427:
6423:
6422:
6417:
6414:
6410:
6409:
6404:
6401:
6397:
6396:
6391:
6388:
6384:
6383:
6378:
6377:
6375:
6371:
6365:
6362:
6360:
6357:
6355:
6352:
6350:
6347:
6345:
6342:
6341:
6339:
6335:
6329:
6326:
6324:
6323:Enzyme family
6321:
6319:
6316:
6314:
6311:
6310:
6308:
6304:
6298:
6295:
6293:
6290:
6288:
6287:Cooperativity
6285:
6283:
6280:
6279:
6277:
6273:
6267:
6264:
6262:
6259:
6257:
6254:
6252:
6249:
6247:
6246:Oxyanion hole
6244:
6242:
6239:
6237:
6234:
6232:
6229:
6228:
6226:
6222:
6218:
6211:
6206:
6204:
6199:
6197:
6192:
6191:
6188:
6168:
6165:
6163:
6160:
6156:
6153:
6152:
6151:
6148:
6147:
6145:
6141:
6135:
6132:
6128:
6125:
6123:
6120:
6118:
6115:
6113:
6110:
6109:
6108:
6105:
6103:
6100:
6098:
6095:
6093:
6090:
6086:
6083:
6081:
6078:
6076:
6073:
6071:
6068:
6067:
6066:
6063:
6059:
6055:
6052:
6050:
6046:
6043:
6042:
6041:
6038:
6037:
6035:
6033:
6029:
6023:
6020:
6015:
6008:
6005:
6003:
6000:
5998:
5995:
5993:
5990:
5989:
5987:
5985:
5981:
5978:
5976:
5971:
5967:
5957:
5954:
5953:
5951:
5949:
5945:
5939:
5936:
5935:
5933:
5931:
5927:
5924:
5922:
5917:
5913:
5910:
5907:
5902:
5897:
5893:
5887:
5884:
5882:
5879:
5877:
5874:
5870:
5867:
5865:
5862:
5860:
5857:
5855:
5852:
5851:
5850:
5849:
5848:arylsulfatase
5845:
5844:
5842:
5840:
5836:
5832:
5826:
5823:
5820:
5816:
5813:
5811:
5808:
5806:
5802:
5799:
5797:
5794:
5792:
5789:
5787:
5784:
5780:
5777:
5776:
5775:
5772:
5768:
5765:
5763:
5760:
5759:
5758:
5757:Phospholipase
5755:
5753:
5750:
5749:
5747:
5745:
5740:
5736:
5730:
5727:
5725:
5722:
5720:
5716:
5713:
5709:
5705:
5701:
5698:
5697:
5696:
5693:
5689:
5686:
5685:
5684:
5681:
5679:
5676:
5674:
5671:
5669:
5666:
5664:
5661:
5657:
5654:
5653:
5652:
5649:
5645:
5642:
5641:
5640:
5637:
5635:
5632:
5630:
5627:
5625:
5621:
5617:
5613:
5610:
5606:
5603:
5601:
5598:
5596:
5593:
5592:
5591:
5588:
5587:
5585:
5583:
5579:
5575:
5569:
5566:
5564:
5561:
5559:
5556:
5555:
5553:
5551:
5547:
5543:
5537:
5534:
5532:
5529:
5528:
5523:
5520:
5518:
5515:
5513:
5510:
5509:
5508:
5507:Phospholipase
5505:
5504:
5499:
5496:
5494:
5491:
5489:
5486:
5484:
5481:
5479:
5476:
5474:
5471:
5469:
5466:
5464:
5461:
5459:
5455:
5452:
5450:
5447:
5446:
5445:
5442:
5441:
5438:
5435:
5433:
5430:
5428:
5425:
5421:
5418:
5416:
5413:
5412:
5411:
5408:
5407:
5405:
5401:
5397:
5393:
5388:
5384:
5380:
5373:
5368:
5366:
5361:
5359:
5354:
5353:
5350:
5333:
5329:
5325:
5322:
5321:
5319:
5316:
5311:
5305:
5302:
5301:
5299:
5296:
5291:
5288:
5286:
5285:Acetylcholine
5282:
5278:
5271:
5267:
5263:
5259:
5256:
5255:
5253:
5251:
5247:
5243:
5233:
5230:
5228:
5225:
5223:
5216:
5214:
5211:
5210:
5208:
5206:
5202:
5198:
5194:
5184:
5181:
5180:
5178:
5175:
5170:
5164:
5161:
5160:
5158:
5155:
5150:
5147:
5145:
5141:
5137:
5125:
5122:
5120:
5117:
5116:
5115:
5112:
5110:
5107:
5106:
5104:
5101:
5096:
5090:
5087:
5085:
5082:
5080:
5073:
5071:
5068:
5067:
5065:
5062:
5057:
5054:
5052:
5048:
5044:
5040:
5030:
5027:
5025:
5022:
5021:
5019:
5016:
5011:
5005:
5002:
5001:
4999:
4996:
4991:
4988:
4986:
4982:
4978:
4975:
4973:
4969:
4965:
4961:
4954:
4949:
4947:
4942:
4940:
4935:
4934:
4931:
4917:
4911:
4906:
4902:
4896:
4891:
4887:
4881:
4876:
4872:
4863:
4858:
4856:
4851:
4849:
4844:
4843:
4840:
4833:
4829:
4828:
4823:
4819:
4815:
4812:
4808:
4807:
4802:
4801:
4796:
4793:
4790:
4787:
4784:
4782:
4781:
4778:
4774:
4772:
4771:
4768:
4764:
4762:
4761:
4758:
4754:
4752:
4751:
4748:
4744:
4742:
4738:
4735:
4734:
4730:
4723:
4719:
4715:
4711:
4707:
4703:
4699:
4695:
4690:
4686:
4682:
4678:
4674:
4670:
4666:
4661:
4657:
4653:
4649:
4645:
4641:
4637:
4632:
4628:
4624:
4619:
4614:
4610:
4606:
4605:J. Biol. Chem
4602:
4597:
4593:
4589:
4585:
4581:
4577:
4573:
4570:(4): 447–59.
4569:
4565:
4560:
4556:
4552:
4548:
4544:
4541:(1): 125–30.
4540:
4536:
4531:
4527:
4523:
4518:
4513:
4508:
4503:
4499:
4495:
4491:
4487:
4483:
4478:
4474:
4470:
4466:
4462:
4458:
4454:
4450:
4446:
4443:(2): 279–82.
4442:
4438:
4433:
4429:
4425:
4420:
4415:
4410:
4405:
4401:
4397:
4393:
4389:
4385:
4380:
4376:
4372:
4367:
4362:
4358:
4354:
4353:J. Biol. Chem
4350:
4345:
4341:
4337:
4332:
4327:
4323:
4319:
4318:J. Biol. Chem
4315:
4310:
4306:
4302:
4297:
4292:
4288:
4284:
4280:
4275:
4271:
4267:
4262:
4257:
4253:
4249:
4248:J. Biol. Chem
4245:
4240:
4236:
4232:
4227:
4222:
4218:
4214:
4210:
4205:
4201:
4197:
4193:
4189:
4186:(4): 1192–7.
4185:
4181:
4175:
4171:
4167:
4163:
4159:
4155:
4151:
4148:(4): 216–24.
4147:
4143:
4138:
4134:
4130:
4126:
4122:
4119:(3): 163–71.
4118:
4114:
4109:
4105:
4101:
4097:
4093:
4090:(6): 332–40.
4089:
4085:
4080:
4076:
4072:
4068:
4064:
4060:
4056:
4052:
4048:
4043:
4039:
4035:
4031:
4027:
4023:
4019:
4015:
4011:
4007:
4003:
3998:
3994:
3990:
3985:
3980:
3976:
3972:
3968:
3963:
3962:
3957:
3949:
3945:
3940:
3935:
3930:
3925:
3921:
3917:
3913:
3906:
3903:
3898:
3894:
3889:
3884:
3880:
3876:
3872:
3868:
3864:
3857:
3854:
3849:
3843:
3839:
3835:
3834:
3826:
3823:
3818:
3814:
3810:
3806:
3802:
3798:
3794:
3790:
3782:
3779:
3774:
3770:
3766:
3762:
3758:
3754:
3747:
3744:
3739:
3733:
3730:
3725:
3721:
3717:
3713:
3709:
3705:
3701:
3697:
3690:
3687:
3682:
3678:
3674:
3670:
3666:
3662:
3658:
3654:
3647:
3644:
3639:
3635:
3630:
3625:
3622:(5): 928–36.
3621:
3617:
3613:
3606:
3603:
3598:
3594:
3590:
3586:
3582:
3578:
3575:(1): 211–35.
3574:
3570:
3563:
3560:
3555:
3551:
3546:
3541:
3537:
3533:
3529:
3522:
3519:
3514:
3510:
3506:
3502:
3498:
3494:
3490:
3486:
3479:
3476:
3471:
3467:
3462:
3457:
3453:
3449:
3445:
3441:
3437:
3430:
3427:
3422:
3418:
3413:
3408:
3405:(6): 965–73.
3404:
3400:
3396:
3389:
3386:
3381:
3375:
3371:
3364:
3361:
3356:
3350:
3346:
3341:
3340:
3331:
3328:
3323:
3317:
3313:
3306:
3303:
3290:
3286:
3280:
3276:
3272:
3265:
3262:
3249:
3245:
3239:
3235:
3234:
3226:
3223:
3211:
3205:
3202:
3187:
3181:
3178:
3173:
3167:
3163:
3159:
3155:
3148:
3145:
3140:
3134:
3130:
3123:
3120:
3115:
3111:
3106:
3101:
3097:
3093:
3089:
3085:
3078:
3071:
3068:
3062:
3057:
3053:
3049:
3045:
3041:
3037:
3030:
3028:
3026:
3024:
3020:
3015:
3011:
3007:
3003:
2999:
2995:
2991:
2987:
2983:
2979:
2978:Ecotoxicology
2975:
2968:
2966:
2962:
2957:
2953:
2949:
2945:
2941:
2934:
2931:
2926:
2922:
2918:
2914:
2910:
2906:
2902:
2895:
2893:
2891:
2889:
2885:
2880:
2878:0-7167-1614-3
2874:
2870:
2863:
2860:
2855:
2851:
2847:
2843:
2836:
2829:
2826:
2821:
2817:
2813:
2809:
2802:
2799:
2794:
2790:
2785:
2780:
2775:
2770:
2766:
2762:
2758:
2754:
2750:
2743:
2740:
2735:
2728:
2724:
2720:
2716:
2712:
2705:
2702:
2697:
2690:
2686:
2681:
2676:
2672:
2668:
2667:J. Biol. Chem
2664:
2657:
2654:
2649:
2642:
2638:
2633:
2628:
2624:
2620:
2617:(1): 95–102.
2616:
2612:
2608:
2601:
2598:
2593:
2589:
2584:
2579:
2575:
2571:
2570:J. Biol. Chem
2567:
2560:
2557:
2552:
2548:
2544:
2540:
2536:
2532:
2524:
2521:
2516:
2512:
2508:
2504:
2500:
2496:
2492:
2488:
2481:
2478:
2473:
2469:
2465:
2461:
2457:
2453:
2449:
2445:
2441:
2437:
2430:
2427:
2422:
2418:
2414:
2410:
2406:
2402:
2395:
2392:
2387:
2383:
2380:(5): 955–79.
2379:
2375:
2368:
2365:
2360:
2354:
2350:
2349:
2341:
2339:
2335:
2330:
2324:
2320:
2313:
2310:
2305:
2301:
2295:
2292:
2287:
2283:
2277:
2274:
2270:
2266:
2261:
2259:
2257:
2253:
2249:
2245:
2240:
2238:
2236:
2232:
2226:
2222:
2219:
2218:
2214:
2208:
2205:
2203:
2200:
2198:
2195:
2193:
2192:Cannabicitran
2190:
2188:
2185:
2183:
2180:
2178:
2175:
2173:
2170:
2169:
2168:
2165:
2164:
2163:
2161:
2157:
2153:
2148:
2146:
2142:
2138:
2134:
2130:
2124:
2116:
2114:
2112:
2111:
2102:
2100:
2098:
2087:
2085:
2083:
2079:
2075:
2071:
2068:
2064:
2060:
2049:
2047:
2045:
2041:
2037:
2033:
2029:
2018:
2016:
2014:
2010:
2009:mRNA splicing
2001:
1999:
1997:
1993:
1990:
1986:
1981:
1974:
1972:
1970:
1965:
1963:
1958:
1956:
1952:
1948:
1944:
1940:
1936:
1932:
1928:
1927:physostigmine
1924:
1920:
1916:
1912:
1908:
1904:
1900:
1896:
1892:
1888:
1879:
1875:
1873:
1869:
1865:
1861:
1855:
1847:
1845:
1843:
1838:
1836:
1832:
1827:
1823:
1815:
1813:
1809:
1807:
1802:
1798:
1792:
1790:
1788:
1784:
1780:
1776:
1772:
1768:
1764:
1760:
1756:
1751:
1749:
1745:
1741:
1737:
1733:
1729:
1724:
1722:
1718:
1714:
1710:
1709:acetylcholine
1706:
1702:
1698:
1689:
1682:
1680:
1678:
1674:
1670:
1666:
1662:
1658:
1654:
1650:
1638:
1637:
1636:
1634:
1630:
1626:
1625:acetylcholine
1622:
1618:
1614:
1610:
1606:
1602:
1598:
1594:
1590:
1578:
1573:
1569:
1565:
1562:
1558:
1551:
1549:
1546:
1542:
1538:
1534:
1531:
1527:
1523:
1516:
1514:
1510:
1504:
1500:
1497:
1491:
1489:
1485:
1481:
1475:
1471:
1467:
1463:
1459:
1455:
1451:
1448:
1444:
1437:
1435:
1431:
1425:
1421:
1418:
1412:
1410:
1406:
1402:
1398:
1392:
1388:
1384:
1380:
1376:
1372:
1368:
1365:
1363:RefSeq (mRNA)
1361:
1354:
1353:
1348:
1344:
1341:
1335:
1334:
1329:
1325:
1322:
1320:
1316:
1309:
1308:
1303:
1299:
1296:
1290:
1289:
1284:
1280:
1277:
1275:
1271:
1264:
1263:
1258:
1254:
1251:
1245:
1244:
1239:
1235:
1232:
1230:
1226:
1223:
1220:
1218:
1215:
1211:
1208:
1204:
1200:
1193:
1189:
1184:
1178:
1175:
1173:
1170:
1168:
1165:
1163:
1160:
1158:
1155:
1153:
1150:
1148:
1145:
1143:
1140:
1138:
1135:
1133:
1130:
1128:
1127:cell adhesion
1125:
1123:
1120:
1118:
1115:
1113:
1110:
1108:
1105:
1103:
1100:
1098:
1095:
1093:
1090:
1088:
1085:
1083:
1080:
1078:
1075:
1074:
1072:
1069:
1068:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1026:cell junction
1024:
1022:
1019:
1017:
1014:
1012:
1009:
1007:
1004:
1002:
999:
997:
994:
993:
991:
988:
987:
981:
978:
976:
973:
971:
968:
966:
963:
961:
958:
956:
953:
951:
948:
946:
943:
941:
938:
936:
933:
931:
928:
926:
923:
921:
918:
917:
915:
912:
911:
908:
907:Gene ontology
904:
900:
888:
883:
879:
872:
867:
864:
862:
858:
850:
845:
834:
830:
826:
822:
818:
814:
810:
806:
802:
798:
797:
794:
790:
785:
782:
772:
768:
764:
760:
756:
752:
748:
744:
740:
736:
735:
732:
728:
723:
720:
719:
716:
714:
710:
708:
707:
703:
702:
699:
697:
693:
689:
685:
681:
673:
668:
664:
660:
655:
645:
641:
634:
627:
621:
614:
606:
602:
598:
593:
589:
584:
580:
572:
567:
563:
559:
554:
544:
540:
533:
526:
520:
513:
509:
503:
499:
495:
490:
486:
481:
477:
473:
469:
465:
461:
457:
453:
449:
445:
441:
437:
429:
424:
417:
412:
407:
396:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
354:
350:
346:
342:
338:
334:
330:
326:
322:
318:
312:
307:
304:
303:
299:
296:
289:
285:
280:
276:
272:
267:
262:
251:
248:
246:
242:
239:
236:
234:
230:
227:
224:
222:
218:
213:
209:
206:
202:
199:
197:
196:Gene Ontology
193:
190:
187:
184:
181:
178:
174:
171:
168:
166:
162:
159:
156:
154:
150:
147:
144:
142:
138:
135:
134:NiceZyme view
132:
130:
126:
123:
120:
118:
114:
111:
108:
106:
102:
97:
94:
91:
89:
85:
82:
79:
77:
73:
68:
61:
56:
51:
48:
44:
40:
33:
19:
8127:
8121:α-Latrotoxin
8109:
8079:
8044:
8013:
7971:
7945:
7930:
7874:Rivastigmine
7840:
7794:Reactivators
7767:Ungiminorine
7722:Kobophenol A
7687:Coronaridine
7677:Bulbocapnine
7672:Arisugacin A
7648:
7633:
7519:Tebupirimfos
7399:Phosphamidon
7304:Methidathion
7209:Fenitrothion
7034:Chlorpyrifos
6974:
6849:Terestigmine
6844:Rivastigmine
6806:Eptastigmine
6757:Phenmedipham
6727:Formparanate
6712:Ethiofencarb
6645:Carbamates:
6642:
6636:
6623:
6555:
6460:Translocases
6457:
6444:
6431:
6418:
6405:
6395:Transferases
6392:
6379:
6236:Binding site
6017:}}
6011:{{
5975:Endonuclease
5906:ribonuclease
5846:
5629:Nucleotidase
5550:Thioesterase
5414:
5327:
5314:
5294:
5173:
5153:
5099:
5060:
5014:
4994:
4962:involved in
4915:
4900:
4885:
4825:
4805:
4799:
4775:
4765:
4755:
4745:
4700:(1): 31–91.
4697:
4693:
4668:
4664:
4639:
4635:
4608:
4604:
4567:
4563:
4538:
4535:Biochemistry
4534:
4489:
4485:
4440:
4436:
4391:
4387:
4356:
4352:
4321:
4317:
4289:(1): 170–7.
4286:
4282:
4251:
4247:
4216:
4212:
4183:
4179:
4145:
4141:
4116:
4112:
4087:
4083:
4050:
4046:
4005:
4001:
3974:
3970:
3922:(1): 85–94.
3919:
3915:
3905:
3870:
3866:
3856:
3832:
3825:
3792:
3789:Biochemistry
3788:
3781:
3756:
3752:
3746:
3732:
3699:
3695:
3689:
3656:
3652:
3646:
3619:
3615:
3605:
3572:
3568:
3562:
3535:
3531:
3521:
3491:(1): 31–91.
3488:
3484:
3478:
3446:(6): 773–7.
3443:
3439:
3429:
3402:
3398:
3388:
3369:
3363:
3338:
3330:
3311:
3305:
3295:February 26,
3293:. Retrieved
3289:the original
3274:
3264:
3254:February 26,
3252:. Retrieved
3248:the original
3232:
3225:
3215:February 24,
3213:. Retrieved
3204:
3194:February 24,
3192:. Retrieved
3180:
3153:
3147:
3129:Neuroscience
3128:
3122:
3087:
3083:
3070:
3043:
3039:
2981:
2977:
2947:
2943:
2933:
2908:
2904:
2868:
2862:
2845:
2841:
2828:
2811:
2807:
2801:
2756:
2752:
2742:
2718:
2714:
2704:
2670:
2666:
2656:
2614:
2610:
2600:
2573:
2569:
2559:
2534:
2531:Biochemistry
2530:
2523:
2490:
2486:
2480:
2439:
2435:
2429:
2404:
2400:
2394:
2377:
2373:
2367:
2348:Neuroscience
2347:
2318:
2312:
2303:
2294:
2285:
2276:
2182:Cannabigerol
2149:
2128:
2126:
2108:
2106:
2103:Nomenclature
2096:
2094:
2080:through the
2056:
2025:
2005:
1982:
1978:
1975:Distribution
1966:
1959:
1943:Rivastigmine
1907:insecticides
1895:asphyxiation
1884:
1857:
1839:
1819:
1810:
1803:
1799:
1796:
1783:nucleophilic
1752:
1725:
1694:
1673:nerve agents
1646:
1608:
1605:AChE, AChase
1604:
1600:
1596:
1588:
1587:
1509:NP_001276939
1506:
1488:NP_001354848
1484:NP_001354847
1480:NP_001354846
1477:
1470:NP_001354844
1466:NP_001289551
1462:NP_001289550
1458:NP_001269378
1430:NM_001290010
1427:
1409:NM_001367919
1405:NM_001367918
1401:NM_001367917
1397:NM_001367915
1394:
1383:NM_001302622
1379:NM_001302621
1375:NM_001282449
1350:
1331:
1305:
1286:
1260:
1241:
1221:
1216:
1021:cell surface
819:hypothalamus
745:hypothalamus
711:
704:
670:137,292,728
657:137,285,781
569:100,896,974
556:100,889,994
431:External IDs
314:
122:BRENDA entry
47:
7972:Inhibitors:
7949:Coluracetam
7931:Inhibitors:
7901:Transporter
7841:Inhibitors:
7813:Pralidoxime
7707:Cyclanoline
7657:α-Viniferin
7554:Trichlorfon
7319:Metrifonate
7234:Fosthiazate
7219:Fluorotabun
7094:Dicrotophos
7049:Crotylsarin
6893:Huperzine A
6888:Galantamine
6883:Edrophonium
6816:Neostigmine
6811:Ganstigmine
6777:Propamocarb
6722:Formetanate
6707:Ethienocarb
6687:Carbosulfan
6677:Carbetamide
6672:Carbendazim
6643:Reversible:
6556:Inhibitors:
6231:Active site
6150:Nuclease S1
5921:Exonuclease
5815:Lecithinase
5644:Calcineurin
5582:Phosphatase
5488:Lipoprotein
5478:Endothelial
5315:catabolism:
5174:catabolism:
5100:catabolism:
5051:epinephrine
5015:catabolism:
4868:PDB gallery
4777:Proteopedia
4767:Proteopedia
4757:Proteopedia
4747:Proteopedia
3873:: 384–393.
3090:(1): 8–13.
2759:(1): 3219.
2407:: 281–320.
2172:Cannabidiol
2067:hydrophobic
2028:collagenous
1787:acetic acid
1721:active site
1657:cholinergic
811:bone marrow
409:Identifiers
110:IntEnz view
70:Identifiers
8187:Categories
8136:versutoxin
8132:robustoxin
8006:Inhibitors
7995:modulators
7946:Enhancers:
7907:modulators
7864:Ladostigil
7854:Conodurine
7849:Affinisine
7762:Ungeremine
7737:Phosacetim
7697:Corynoline
7692:Corydaline
7682:Conodurine
7667:Affinisine
7603:Demecarium
7601:; Others:
7514:Tabun (GA)
7504:Soman (GD)
7494:Sarin (GB)
7414:Profenofos
7274:Isoxathion
7259:Guanitoxin
7229:Formothion
7204:Fenamiphos
7134:Disulfoton
7129:Dioxathion
7119:Dimethoate
7089:Dichlorvos
6923:Ladostigil
6913:Ipidacrine
6858:Ambenonium
6853:Acotiamide
6851:; Others:
6824:Phenserine
6801:Distigmine
6792:Thiodicarb
6767:Pirimicarb
6732:Methiocarb
6717:Fenobucarb
6692:Chlorbufam
6682:Carbofuran
6657:Bendiocarb
6638:Inhibitors
6532:modulators
6518:modulators
6511:metabolism
6434:Isomerases
6408:Hydrolases
6275:Regulation
5463:Pancreatic
5400:Carboxylic
5295:anabolism:
5197:tryptophan
5154:anabolism:
5061:anabolism:
4995:anabolism:
4671:: 147–53.
3440:Mol. Pharm
2611:Biochem. J
2271:, May 2017
2250:, May 2017
2227:References
2207:Cannabinol
2117:Inhibitors
2063:C-terminus
1996:oligomeric
1923:Carbamates
1903:covalently
1831:acetyl-CoA
1740:tryptophan
1732:inhibitors
1701:hydrolyzes
1695:AChE is a
1677:pesticides
715:(ortholog)
452:HomoloGene
179:structures
146:KEGG entry
93:9000-81-1
8118:agonists:
8102:Enhancers
7975:Vesamicol
7859:Cymserine
7808:Obidoxime
7803:Methoxime
7717:Harmaline
7712:Cymserine
7702:Crimidine
7649:Unsorted:
7544:Triazofos
7484:Ro 3-0433
7479:Ro 3-0422
7474:Ro 3-0419
7469:Ro 3-0417
7464:Ro 3-0412
7459:Ro 3-0411
7454:Ro 3-0397
7449:Ro 3-0352
7444:Ro 3-0351
7439:Ro 3-0347
7434:Ro 3-0346
7429:Ro 3-0340
7419:Prothoate
7389:Phosfolan
7384:Phosalone
7369:Parathion
7354:Omethoate
7324:Mevinphos
7289:Malathion
7279:Leptophos
7184:Endothion
7064:Demephion
7054:Cyanophos
7044:Coumaphos
7014:Cadusafos
7009:Bensulide
7004:BAY-29952
6968:Zanapezil
6928:Minaprine
6908:Huprine Y
6903:Huprine X
6898:Huprine W
6868:Donepezil
6797:Thiofanox
6772:Promecarb
6762:Pinmicarb
6742:Metolcarb
6702:Dimetilan
6662:Bufencarb
6652:Aminocarb
6604:CM-54,903
6515:transport
6313:EC number
6040:RNase III
5898:(includes
5839:Sulfatase
5752:Autotaxin
5616:Prostatic
5468:Lysosomal
5383:esterases
5379:Hydrolase
5218:Aromatic
5205:melatonin
5201:serotonin
5140:glutamate
5075:Aromatic
4985:histamine
4981:histidine
4972:monoamine
4794:—RCSB PDB
4437:FEBS Lett
2925:265016505
2145:donepezil
2078:membranes
2074:PI-anchor
2059:erythroid
2002:AChE gene
1935:donepezil
1911:malathion
1891:bronchial
1887:paralysis
1775:aspartate
1767:glutamate
1763:histidine
1748:angstroms
1717:substrate
1713:diffusion
1705:catalytic
1697:hydrolase
1621:catalyzes
1513:NP_033729
1454:NP_000656
1434:NM_009599
1387:NM_015831
1371:NM_000665
1207:Orthologs
460:GeneCards
99:Databases
8203:EC 3.1.1
8158:See also
8142:Crotoxin
7844:Affinine
7777:BW284C51
7732:Lycorine
7662:Affinine
7652:α-Pinene
7630:Onchidal
7549:Tribufos
7529:Terbufos
7499:Schradan
7364:Paraoxon
7284:Malaoxon
7214:Fenthion
7199:Ethoprop
7084:Diazinon
7079:Dialifor
6984:Acephate
6918:Itopride
6863:Caffeine
6787:Propoxur
6737:Methomyl
6667:Carbaryl
6647:Aldicarb
6337:Kinetics
6261:Cofactor
6224:Activity
6134:RNase T1
5896:Nuclease
5531:Cutinase
5246:arginine
5047:dopamine
5043:tyrosine
4722:21601586
4592:22975039
4473:41843002
4180:Genomics
4170:18983474
4162:16516310
4133:12769797
4104:12069617
4067:11283752
4038:28833513
3948:35702400
3897:30953774
3817:11744952
3809:10353814
3773:17379257
3753:Life Sci
3724:18541228
3681:39348660
3673:22750491
3597:23021010
3589:13130712
3554:13808985
3513:21601586
3470:17140265
3421:20005135
3399:Immunity
3014:25702252
3006:16676216
2793:28607438
2472:28833513
2267:–
2246:–
2215:See also
2152:Gulf War
1992:antigens
1931:glaucoma
1826:synaptic
1765:447 and
1736:aromatic
1671:such as
1561:Wikidata
1186:Sources:
1001:membrane
250:proteins
238:articles
226:articles
183:RCSB PDB
8128:Others:
8080:Others:
8016:SNAP-25
7989:Release
7879:Tacrine
7787:3152 CT
7752:Taspine
7524:Temefos
7424:R-16661
7394:Phosmet
7379:Phorate
7329:Mipafox
7294:Mazidox
7224:Fonofos
7169:EA-4352
7164:EA-3148
7159:EA-2613
7154:EA-2192
7149:EA-2098
7144:EA-2054
7139:EA-2012
7114:Dimefox
7069:Demeton
6963:Tacrine
6958:TL-1238
6878:EA-4056
6873:EA-3990
6782:Propham
6747:Miotine
6447:Ligases
6217:Enzymes
6107:RNase E
6102:RNase Z
6097:RNase A
6092:RNase P
6065:RNase H
5683:Phytase
5483:Hepatic
5458:Lingual
5454:Gastric
5281:choline
4960:Enzymes
4832:PDBe-KB
4822:UniProt
4714:8321908
4685:8248502
4656:8125298
4627:7836436
4584:7085778
4555:3954986
4526:2734315
4494:Bibcode
4465:2714437
4445:Bibcode
4428:2263619
4396:Bibcode
4375:1748670
4340:1744105
4305:1609795
4296:1682883
4270:1517212
4235:1391965
4200:1380483
4075:5947744
4030:1678899
4010:Bibcode
4002:Science
3993:3319614
3939:9149358
3888:6790976
3704:Bibcode
3638:8488842
3629:1682033
3545:1244416
3505:8321908
3461:2562334
3347:–2472.
3114:2408211
3048:Bibcode
2986:Bibcode
2784:5468367
2761:Bibcode
2689:8349597
2641:9742217
2632:1219756
2592:7836436
2551:1356436
2515:8343975
2495:Bibcode
2464:1678899
2444:Bibcode
2436:Science
2421:8042853
2269:Ensembl
2248:Ensembl
2141:tacrine
2097:Torpedo
2072:with a
2070:peptide
1909:(e.g.,
1860:inhibit
1820:During
1793:Species
1779:choline
1715:of the
1655:of the
1651:and in
1629:choline
1595:symbol
1319:UniProt
1274:Ensembl
1213:Species
1192:QuickGO
1041:nucleus
1011:synapse
769:putamen
690:pattern
416:Aliases
205:QuickGO
170:profile
153:MetaCyc
88:CAS no.
81:3.1.1.7
7489:Ronnel
7404:Phoxim
7194:Ethion
6989:Armine
6953:TL-599
6948:T-1194
6943:T-1152
6938:T-1123
6752:Oxamyl
6526:Enzyme
6421:Lyases
6045:Drosha
5970:3.1.21
5938:RecBCD
5916:3.1.11
5536:PETase
5444:Lipase
4827:P22303
4797:Human
4720:
4712:
4683:
4654:
4625:
4590:
4582:
4553:
4524:
4517:287342
4514:
4471:
4463:
4426:
4416:
4373:
4338:
4303:
4293:
4268:
4233:
4198:
4168:
4160:
4131:
4102:
4073:
4065:
4036:
4028:
3991:
3946:
3936:
3895:
3885:
3844:
3815:
3807:
3771:
3722:
3679:
3671:
3636:
3626:
3595:
3587:
3552:
3542:
3511:
3503:
3468:
3458:
3419:
3376:
3351:
3318:
3281:
3240:
3168:
3135:
3112:
3012:
3004:
2923:
2875:
2791:
2781:
2687:
2639:
2629:
2590:
2549:
2513:
2470:
2462:
2419:
2355:
2325:
1949:, and
1759:serine
1719:. The
1617:enzyme
1547:search
1545:PubMed
1352:P21836
1333:P22303
1229:Entrez
861:BioGPS
548:7q22.1
440:100740
233:PubMed
215:Search
201:AmiGO
189:PDBsum
129:ExPASy
117:BRENDA
105:IntEnz
76:EC no.
7960:VAChT
7782:TMTFA
7344:Naled
7249:GT-45
7239:GD-42
6589:AF64A
6373:Types
6054:Dicer
6009:;see
5835:3.1.6
5805:PDE4B
5801:PDE4A
5739:3.1.4
5708:IMPA3
5704:IMPA2
5700:IMPA1
5578:3.1.3
5546:3.1.2
5396:3.1.1
4788:—PDBe
4739:U.S.
4718:S2CID
4588:S2CID
4469:S2CID
4419:55238
4213:Blood
4166:S2CID
4071:S2CID
4034:S2CID
3813:S2CID
3677:S2CID
3593:S2CID
3509:S2CID
3189:(PDF)
3080:(PDF)
3010:S2CID
2921:S2CID
2838:(PDF)
2468:S2CID
2040:PRiMA
2032:lipid
2030:, or
1915:Sarin
1761:203,
1728:amine
1699:that
1619:that
1262:11423
1222:Mouse
1217:Human
1188:Amigo
713:Mouse
706:Human
653:Start
588:Mouse
552:Start
485:Human
448:87876
165:PRIAM
8112:LPHN
8047:VAMP
7829:BChE
7339:MSPI
6625:AChE
6599:BETA
6594:B115
6544:ChAT
6513:and
6465:list
6458:EC7
6452:list
6445:EC6
6439:list
6432:EC5
6426:list
6419:EC4
6413:list
6406:EC3
6400:list
6393:EC2
6387:list
6380:EC1
5972:-31:
5918:-16:
5904:and
5810:PDE5
5796:PDE3
5791:PDE2
5786:PDE1
5678:PTEN
5663:OCRL
5656:PP2A
5605:ALPP
5600:ALPL
5595:ALPI
5389:3.1)
5270:NOS3
5266:NOS2
5262:NOS1
5144:GABA
4916:1vzj
4901:1f8u
4886:1b41
4820:for
4806:ACHE
4800:ACHE
4710:PMID
4681:PMID
4652:PMID
4636:Gene
4623:PMID
4580:PMID
4551:PMID
4522:PMID
4461:PMID
4424:PMID
4371:PMID
4336:PMID
4301:PMID
4266:PMID
4231:PMID
4196:PMID
4158:PMID
4129:PMID
4100:PMID
4063:PMID
4026:PMID
3989:PMID
3944:PMID
3893:PMID
3842:ISBN
3805:PMID
3769:PMID
3720:PMID
3669:PMID
3634:PMID
3585:PMID
3550:PMID
3501:PMID
3466:PMID
3417:PMID
3374:ISBN
3349:ISBN
3345:2469
3316:ISBN
3297:2012
3279:ISBN
3256:2012
3238:ISBN
3217:2012
3196:2012
3166:ISBN
3133:ISBN
3110:PMID
3002:PMID
2873:ISBN
2789:PMID
2685:PMID
2637:PMID
2588:PMID
2547:PMID
2511:PMID
2460:PMID
2417:PMID
2353:ISBN
2323:ISBN
2160:HPLC
2143:and
2135:and
2088:AChE
2050:AChE
2044:ColQ
2036:ColQ
2019:AChE
2011:and
1917:and
1870:and
1675:and
1597:ACHE
1593:HGNC
975:ACHE
803:pons
696:Bgee
644:Band
605:Chr.
543:Band
502:Chr.
464:ACHE
436:OMIM
423:ACHE
393:5HFA
389:5HF8
385:5FPQ
381:5HF6
377:5HF9
373:5FOQ
369:4EY8
365:4EY6
361:4EY5
357:4EY4
353:1B41
349:2X8B
345:1VZJ
341:4M0F
337:4M0E
333:4BDT
329:3LII
325:1F8U
321:4PQE
317:4EY7
298:RCSB
295:PDBe
264:ACHE
245:NCBI
186:PDBe
141:KEGG
32:Ache
18:AChE
7919:CHT
7189:EPN
6127:4/5
4818:PDB
4702:doi
4673:doi
4644:doi
4640:138
4613:doi
4609:270
4572:doi
4543:doi
4512:PMC
4502:doi
4453:doi
4441:247
4414:PMC
4404:doi
4361:doi
4357:266
4326:doi
4322:266
4291:PMC
4256:doi
4252:267
4221:doi
4188:doi
4150:doi
4121:doi
4092:doi
4055:doi
4018:doi
4006:253
3979:doi
3975:170
3934:PMC
3924:doi
3883:PMC
3875:doi
3797:doi
3761:doi
3712:doi
3700:175
3661:doi
3624:PMC
3577:doi
3573:100
3540:PMC
3493:doi
3456:PMC
3448:doi
3407:doi
3158:doi
3100:hdl
3092:doi
3056:doi
2994:doi
2952:doi
2913:doi
2850:doi
2816:doi
2779:PMC
2769:doi
2723:doi
2675:doi
2671:268
2627:PMC
2619:doi
2615:335
2578:doi
2574:270
2539:doi
2503:doi
2452:doi
2440:253
2409:doi
2382:doi
1921:).
1897:.
1607:or
666:End
565:End
468:OMA
456:543
444:MGI
288:PDB
221:PMC
177:PDB
41:or
8189::
8134:,
8089:,
8070:,
8066:,
8062:,
8035:,
8031:,
7796::
7622:,
7618:,
7614:,
7599:VX
7594:VR
7589:VS
7584:VP
7579:VM
7574:VG
7569:VE
7254:GV
7244:GH
6085:2C
6080:2B
6075:2A
6056::
6047::
5837::
5717::
5706:,
5702:,
5618:)/
5580::
5548::
5517:A2
5512:A1
5398::
5387:EC
5381::
5330:,
5268:,
5264:,
5250:NO
4983:→
4824::
4716:.
4708:.
4698:41
4696:.
4679:.
4669:98
4667:.
4650:.
4638:.
4621:.
4607:.
4603:.
4586:.
4578:.
4568:18
4566:.
4549:.
4539:25
4537:.
4520:.
4510:.
4500:.
4490:86
4488:.
4484:.
4467:.
4459:.
4451:.
4439:.
4422:.
4412:.
4402:.
4392:87
4390:.
4386:.
4369:.
4355:.
4351:.
4334:.
4320:.
4316:.
4299:.
4287:51
4285:.
4281:.
4264:.
4250:.
4246:.
4229:.
4217:80
4215:.
4211:.
4194:.
4184:13
4182:.
4164:.
4156:.
4146:29
4144:.
4127:.
4115:.
4098:.
4088:35
4086:.
4069:.
4061:.
4049:.
4032:.
4024:.
4016:.
4004:.
3987:.
3973:.
3969:.
3942:.
3932:.
3918:.
3914:.
3891:.
3881:.
3871:80
3869:.
3865:.
3840:.
3838:50
3811:.
3803:.
3793:38
3791:.
3767:.
3757:80
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