242:
219:
116:
141:
500:
493:
248:
147:
2091:
1183:
West J, Tompkins CK, Balantac N, Nudelman E, Meengs B, White T, Bursten S, Coleman J, Kumar A, Singer JW, Leung DW (Jun 1997). "Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells".
1474:
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation".
1374:
Garg A, Wilson R, Barnes R, Arioglu E, Zaidi Z, Gurakan F, Kocak N, O'Rahilly S, Taylor SI, Patel SB, Bowcock AM (Sep 1999). "A gene for congenital generalized lipodystrophy maps to human chromosome 9q34".
1555:
Haque W, Garg A, Agarwal AK (Feb 2005). "Enzymatic activity of naturally occurring 1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated with congenital generalized lipodystrophy".
1047:, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
1670:
Lloyd EE, Gaubatz JW, Burns AR, Pownall HJ (May 2007). "Sustained elevations in NEFA induce cyclooxygenase-2 activity and potentiate THP-1 macrophage foam cell formation".
1341:"Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex"
255:
154:
1629:"Phenotypic heterogeneity in biochemical parameters correlates with mutations in AGPAT2 or Seipin genes among Berardinelli-Seip congenital lipodystrophy patients"
1514:"Mutations in Gng3lg and AGPAT2 in Berardinelli-Seip congenital lipodystrophy and Brunzell syndrome: phenotype variability suggests important modifier effects"
1920:
1915:
1441:"Phenotypic heterogeneity in body fat distribution in patients with congenital generalized lipodystrophy caused by mutations in the AGPAT2 or seipin genes"
1721:
738:
719:
77:
1903:
2160:
1910:
2136:
1124:
1106:
2155:
1898:
1586:"Expression of lysophosphatidic acid acyltransferase beta (LPAAT-beta) in ovarian carcinoma: correlation with tumour grading and prognosis"
1044:
2070:
1240:
946:
241:
2038:
1854:
1792:
953:
218:
1222:
1849:
1844:
1787:
1093:
1072:
1512:
Fu M, Kazlauskaite R, Baracho Mde F, Santos MG, BrandĂŁo-Neto J, Villares S, Celi FS, Wajchenberg BL, Shuldiner AR (Jun 2004).
1802:
1714:
1043:
to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with
1246:
1089:
140:
115:
1967:
1947:
1861:
1068:
1888:
1782:
1777:
57:
2050:
1824:
254:
153:
2060:
1893:
1767:
247:
146:
1223:"Entrez Gene: AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)"
2129:
2008:
1984:
1935:
1819:
1772:
1747:
1707:
2013:
1738:
783:
65:
1584:
Niesporek S, Denkert C, Weichert W, Köbel M, Noske A, Sehouli J, Singer JW, Dietel M, Hauptmann S (May 2005).
1144:"Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3"
2055:
1962:
764:
2023:
2018:
1883:
2003:
1998:
1040:
1036:
2122:
2065:
1952:
1939:
1839:
129:
1797:
1404:
Agarwal AK, Arioglu E, De
Almeida S, Akkoc N, Taylor SI, Bowcock AM, Barnes RI, Garg A (May 2002).
1252:
904:
857:
44:
1658:
1500:
89:
929:
908:
878:
853:
499:
2028:
1757:
1687:
1650:
1615:
1572:
1543:
1492:
1462:
1427:
1392:
1362:
1327:
1284:
1201:
1165:
37:
2106:
1298:"A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases"
1993:
1957:
1679:
1640:
1605:
1597:
1564:
1533:
1525:
1484:
1452:
1417:
1384:
1352:
1317:
1309:
1276:
1193:
1155:
334:
265:
209:
164:
85:
492:
2033:
1734:
1699:
1683:
309:
1610:
1585:
1538:
1513:
1322:
1297:
653:
648:
643:
638:
633:
628:
623:
618:
613:
608:
592:
587:
582:
577:
572:
567:
551:
546:
541:
2149:
1406:"AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34"
528:
1504:
69:
2102:
1662:
327:
106:
48:, 1-BSCL, BSCL1, LPAAB, LPAAT-beta, 1-acylglycerol-3-phosphate O-acyltransferase 2
93:
1972:
1730:
1129:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1111:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1568:
410:
1645:
1628:
226:
123:
73:
1160:
1143:
1197:
683:
470:
348:
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192:
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81:
1691:
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1619:
1601:
1576:
1547:
1529:
1496:
1466:
1457:
1440:
1431:
1396:
1388:
1357:
1340:
1288:
1366:
1331:
1205:
1169:
993:
988:
1762:
1280:
977:
828:
809:
1296:
Stamps AC, Elmore MA, Hill ME, Kelly K, Makda AA, Finnen MJ (Sep 1997).
795:
750:
1313:
2043:
1871:
1866:
1807:
1013:
961:
705:
2090:
1488:
1925:
1812:
1422:
1405:
668:
664:
2098:
1829:
1020:
508:
61:
1703:
1267:
Garg A (Mar 2004). "Acquired and inherited lipodystrophies".
1031:
This gene encodes a member of the 1-acylglycerol-3-phosphate
1035:-acyltransferase family. The protein is located within the
639:
positive regulation of cytokine-mediated signaling pathway
1627:
Gomes KB, Pardini VC, Ferreira AC, Fernandes AP (2006).
317:
2110:
552:
1-acylglycerol-3-phosphate O-acyltransferase activity
482:
1518:
The
Journal of Clinical Endocrinology and Metabolism
1445:
The
Journal of Clinical Endocrinology and Metabolism
1377:
The
Journal of Clinical Endocrinology and Metabolism
1983:
1934:
1746:
1557:
922:
897:
871:
846:
1085:
1083:
1081:
1064:
1062:
1060:
264:
163:
16:Protein-coding gene in the species Homo sapiens
1142:Eberhardt C, Gray PW, Tjoelker LW (Aug 1997).
1090:GRCm38: Ensembl release 89: ENSMUSG00000026922
2130:
1715:
8:
1921:2-acylglycerol-3-phosphate O-acyltransferase
1916:1-acylglycerol-3-phosphate O-acyltransferase
1069:GRCh38: Ensembl release 89: ENSG00000169692
2137:
2123:
1722:
1708:
1700:
1010:-glycerol-3-phosphate acyltransferase beta
679:
614:positive regulation of cytokine production
524:
305:
204:
101:
1644:
1609:
1537:
1456:
1421:
1356:
1321:
1159:
1217:
1215:
1056:
624:CDP-diacylglycerol biosynthetic process
1911:Glycerol-3-phosphate O-acyltransferase
1633:Journal of Inherited Metabolic Disease
644:phosphatidic acid biosynthetic process
18:
1904:Lecithin—cholesterol acyltransferase
1684:10.1016/j.atherosclerosis.2006.06.014
269:
230:
225:
168:
127:
122:
7:
2087:
2085:
1899:Glyceronephosphate O-acyltransferase
1045:congenital generalized lipodystrophy
2071:Sulfoacetaldehyde acetyltransferase
1763:Acetyl-Coenzyme A acetyltransferase
1345:The Journal of Biological Chemistry
1269:The New England Journal of Medicine
1148:The Journal of Biological Chemistry
2109:. You can help Knowledge (XXG) by
1987:: converted into alkyl on transfer
1339:Aguado B, Campbell RD (Feb 1998).
919:
894:
868:
843:
819:
800:
774:
755:
729:
710:
487:
405:
343:
322:
14:
1793:Chloramphenicol acetyltransferase
1016:that in humans is encoded by the
609:phospholipid biosynthetic process
2089:
1845:Carnitine O-palmitoyltransferase
498:
491:
253:
246:
240:
217:
152:
145:
139:
114:
1788:Beta-galactoside transacetylase
1803:Serotonin N-acetyl transferase
1750:: other than amino-acyl groups
649:phospholipid metabolic process
578:integral component of membrane
568:endoplasmic reticulum membrane
509:More reference expression data
471:More reference expression data
1:
2161:Human chromosome 9 gene stubs
1968:Keratinocyte transglutaminase
1948:Gamma-glutamyl transpeptidase
1862:Serine C-palmitoyltransferase
238:
137:
1889:Aminolevulinic acid synthase
1783:Acetyl-CoA C-acyltransferase
1778:Dihydrolipoyl transacetylase
1439:Simha V, Garg A (Nov 2003).
2156:Genes on human chromosome 9
2051:2-hydroxyglutarate synthase
425:subcutaneous adipose tissue
371:subcutaneous adipose tissue
2177:
2084:
2061:2-isopropylmalate synthase
1894:Beta-ketoacyl-ACP synthase
1768:N-Acetylglutamate synthase
1569:10.1016/j.bbrc.2004.12.024
1251:gene details page in the
359:mucosa of transverse colon
2009:Decylhomocitrate synthase
1820:Histone acetyltransferase
1773:Choline acetyltransferase
1646:10.1007/s10545-005-0038-5
1590:British Journal of Cancer
1125:"Mouse PubMed Reference:"
1107:"Human PubMed Reference:"
992:
987:
983:
976:
960:
947:Chr 9: 136.67 – 136.69 Mb
941:
926:
901:
890:
875:
850:
839:
826:
822:
807:
803:
794:
781:
777:
762:
758:
749:
736:
732:
717:
713:
704:
689:
682:
678:
662:
593:specific granule membrane
527:
523:
506:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
2014:2-methylcitrate synthase
1161:10.1074/jbc.272.32.20299
654:neutrophil degranulation
542:acyltransferase activity
2056:3-propylmalate synthase
1963:Tissue transglutaminase
1302:The Biochemical Journal
1198:10.1089/dna.1997.16.691
954:Chr 2: 26.48 – 26.49 Mb
441:interventricular septum
395:upper lobe of left lung
2024:3-ethylmalate synthase
2019:2-ethylmalate synthase
1884:Acyltransferase like 2
1602:10.1038/sj.bjc.6602528
1530:10.1210/jc.2003-030485
1458:10.1210/jc.2003-030835
1389:10.1210/jcem.84.9.6103
1358:10.1074/jbc.273.7.4096
1039:membrane and converts
2004:Citrate (Re)-synthase
1999:Decylcitrate synthase
1940:Aminoacyltransferases
1840:palmitoyltransferases
1041:lysophosphatidic acid
1037:endoplasmic reticulum
634:epidermis development
583:endoplasmic reticulum
2066:Homocitrate synthase
1953:Peptidyl transferase
1477:Nature Biotechnology
1281:10.1056/NEJMra025261
1245:genome location and
1186:DNA and Cell Biology
547:transferase activity
429:white adipose tissue
421:brown adipose tissue
232:Chromosome 2 (mouse)
130:Chromosome 9 (human)
1798:N-acetyltransferase
1253:UCSC Genome Browser
367:right lobe of liver
2097:This article on a
1758:acetyltransferases
784:ENSMUSG00000026922
602:Biological process
561:Cellular component
535:Molecular function
437:left lobe of liver
433:intercostal muscle
94:AGPAT2 - orthologs
2118:
2117:
2079:
2078:
2029:ATP citrate lyase
1314:10.1042/bj3260455
1154:(32): 20299–305.
1003:
1002:
999:
998:
972:
971:
937:
936:
916:
915:
886:
885:
865:
864:
835:
834:
816:
815:
790:
789:
771:
770:
745:
744:
726:
725:
674:
673:
519:
518:
515:
514:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
2168:
2139:
2132:
2125:
2093:
2086:
2039:HMG-CoA synthase
1994:Citrate synthase
1958:Transglutaminase
1735:acyltransferases
1724:
1717:
1710:
1701:
1695:
1666:
1648:
1623:
1613:
1580:
1551:
1541:
1508:
1470:
1460:
1435:
1425:
1400:
1370:
1360:
1335:
1325:
1292:
1227:
1226:
1219:
1210:
1209:
1180:
1174:
1173:
1163:
1139:
1133:
1132:
1121:
1115:
1114:
1103:
1097:
1087:
1076:
1066:
985:
984:
956:
949:
932:
920:
911:
895:
891:RefSeq (protein)
881:
869:
860:
844:
820:
801:
775:
756:
730:
711:
680:
629:lipid metabolism
525:
511:
502:
495:
488:
473:
413:
411:Top expressed in
406:
375:body of pancreas
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
2176:
2175:
2171:
2170:
2169:
2167:
2166:
2165:
2146:
2145:
2144:
2143:
2082:
2080:
2075:
2034:Malate synthase
1979:
1930:
1742:
1728:
1698:
1672:Atherosclerosis
1669:
1626:
1583:
1554:
1511:
1473:
1438:
1410:Nature Genetics
1403:
1373:
1351:(7): 4096–105.
1338:
1295:
1275:(12): 1220–34.
1266:
1262:
1260:Further reading
1236:
1231:
1230:
1221:
1220:
1213:
1182:
1181:
1177:
1141:
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1123:
1122:
1118:
1105:
1104:
1100:
1088:
1079:
1067:
1058:
1053:
1029:
994:View/Edit Mouse
989:View/Edit Human
952:
945:
942:Location (UCSC)
928:
907:
903:
877:
856:
852:
765:ENSG00000169692
658:
597:
588:plasma membrane
556:
507:
497:
496:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
363:mucosa of ileum
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
2174:
2172:
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2158:
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2147:
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2127:
2119:
2116:
2115:
2094:
2077:
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2068:
2063:
2058:
2053:
2048:
2047:
2046:
2036:
2031:
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2016:
2011:
2006:
2001:
1996:
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1744:
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1729:
1727:
1726:
1719:
1712:
1704:
1697:
1696:
1667:
1639:(6): 1123–31.
1624:
1596:(9): 1729–36.
1581:
1552:
1524:(6): 2916–22.
1509:
1489:10.1038/nbt971
1471:
1451:(11): 5433–7.
1436:
1401:
1371:
1336:
1293:
1263:
1261:
1258:
1257:
1256:
1235:
1234:External links
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1228:
1211:
1192:(6): 691–701.
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310:RNA expression
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33:
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10:
9:
6:
4:
3:
2:
2173:
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2159:
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2151:
2140:
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2128:
2126:
2121:
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1754:
1752:
1749:
1745:
1740:
1736:
1732:
1725:
1720:
1718:
1713:
1711:
1706:
1705:
1702:
1693:
1689:
1685:
1681:
1677:
1673:
1668:
1664:
1660:
1656:
1652:
1647:
1642:
1638:
1634:
1630:
1625:
1621:
1617:
1612:
1607:
1603:
1599:
1595:
1591:
1587:
1582:
1578:
1574:
1570:
1566:
1563:(2): 446–53.
1562:
1558:
1553:
1549:
1545:
1540:
1535:
1531:
1527:
1523:
1519:
1515:
1510:
1506:
1502:
1498:
1494:
1490:
1486:
1483:(6): 707–16.
1482:
1478:
1472:
1468:
1464:
1459:
1454:
1450:
1446:
1442:
1437:
1433:
1429:
1424:
1423:10.1038/ng880
1419:
1415:
1411:
1407:
1402:
1398:
1394:
1390:
1386:
1383:(9): 3390–4.
1382:
1378:
1372:
1368:
1364:
1359:
1354:
1350:
1346:
1342:
1337:
1333:
1329:
1324:
1319:
1315:
1311:
1308:(2): 455–61.
1307:
1303:
1299:
1294:
1290:
1286:
1282:
1278:
1274:
1270:
1265:
1264:
1259:
1254:
1250:
1249:
1244:
1243:
1238:
1237:
1233:
1224:
1218:
1216:
1212:
1207:
1203:
1199:
1195:
1191:
1187:
1179:
1176:
1171:
1167:
1162:
1157:
1153:
1149:
1145:
1138:
1135:
1130:
1126:
1120:
1117:
1112:
1108:
1102:
1099:
1095:
1091:
1086:
1084:
1082:
1078:
1074:
1070:
1065:
1063:
1061:
1057:
1050:
1048:
1046:
1042:
1038:
1034:
1026:
1024:
1022:
1019:
1015:
1011:
1009:
995:
990:
986:
982:
979:
975:
968:
966:
963:
959:
955:
951:
948:
944:
940:
933:
931:
925:
921:
918:
912:
910:
906:
900:
896:
893:
889:
882:
880:
874:
870:
867:
861:
859:
855:
849:
845:
842:
840:RefSeq (mRNA)
838:
831:
830:
825:
821:
818:
812:
811:
806:
802:
799:
797:
793:
786:
785:
780:
776:
773:
767:
766:
761:
757:
754:
752:
748:
741:
740:
735:
731:
728:
722:
721:
716:
712:
709:
707:
703:
700:
697:
695:
692:
688:
685:
681:
677:
670:
666:
661:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
620:
617:
615:
612:
610:
607:
606:
604:
601:
600:
594:
591:
589:
586:
584:
581:
579:
576:
574:
571:
569:
566:
565:
563:
560:
559:
553:
550:
548:
545:
543:
540:
539:
537:
534:
533:
530:
529:Gene ontology
526:
522:
510:
505:
501:
494:
489:
486:
484:
480:
472:
467:
456:
453:mammary gland
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
383:right auricle
382:
379:apex of heart
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
2111:expanding it
2103:chromosome 9
2096:
2081:
1880:
1838:
1756:
1731:Transferases
1678:(1): 49–55.
1675:
1671:
1636:
1632:
1593:
1589:
1560:
1556:
1521:
1517:
1480:
1476:
1448:
1444:
1413:
1409:
1380:
1376:
1348:
1344:
1305:
1301:
1272:
1268:
1247:
1241:
1189:
1185:
1178:
1151:
1147:
1137:
1128:
1119:
1110:
1101:
1032:
1030:
1017:
1007:
1005:
1004:
927:
905:NP_001012745
902:
876:
858:NM_001012727
851:
827:
808:
782:
763:
737:
718:
698:
693:
333:
326:
191:136,687,457
178:136,673,143
53:External IDs
1973:Factor XIII
1416:(1): 21–3.
445:granulocyte
292:26,494,429
279:26,483,069
271:2|2 A3
31:Identifiers
2150:Categories
1096:, May 2017
1075:, May 2017
1051:References
619:metabolism
391:right lung
337:(ortholog)
74:HomoloGene
2101:on human
930:NP_080488
909:NP_006403
879:NM_026212
854:NM_006412
684:Orthologs
82:GeneCards
1825:P300/CBP
1692:16870193
1655:16435205
1620:15841084
1577:15629135
1548:15181077
1505:27764390
1497:15146197
1467:14602785
1432:11967537
1397:10487716
1289:15028826
1092:–
1071:–
1027:Function
978:Wikidata
663:Sources:
573:membrane
457:duodenum
387:duodenum
1663:2333336
1611:2362024
1539:3390418
1367:9461603
1332:9291118
1323:1218691
1206:9212163
1170:9242711
1094:Ensembl
1073:Ensembl
1006:1-acyl-
796:UniProt
751:Ensembl
690:Species
669:QuickGO
449:jejunum
312:pattern
70:1914762
38:Aliases
2044:HMGCS2
1881:other:
1872:SPTLC2
1867:SPTLC1
1808:HGSNAT
1690:
1661:
1653:
1618:
1608:
1575:
1546:
1536:
1503:
1495:
1465:
1430:
1395:
1365:
1330:
1320:
1287:
1248:AGPAT2
1242:AGPAT2
1239:Human
1204:
1168:
1018:AGPAT2
1014:enzyme
1012:is an
964:search
962:PubMed
829:Q8K3K7
810:O15120
706:Entrez
483:BioGPS
170:9q34.3
86:AGPAT2
62:603100
45:AGPAT2
22:AGPAT2
2105:is a
1985:2.3.3
1936:2.3.2
1926:ABHD5
1813:ARD1A
1748:2.3.1
1659:S2CID
1501:S2CID
739:67512
720:10555
699:Mouse
694:Human
665:Amigo
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
2107:stub
2099:gene
1855:CPT2
1850:CPT1
1830:NAT2
1741:2.3)
1688:PMID
1651:PMID
1616:PMID
1573:PMID
1544:PMID
1493:PMID
1463:PMID
1428:PMID
1393:PMID
1363:PMID
1328:PMID
1285:PMID
1202:PMID
1166:PMID
1021:gene
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
78:4678
58:OMIM
1680:doi
1676:192
1641:doi
1606:PMC
1598:doi
1565:doi
1561:327
1534:PMC
1526:doi
1485:doi
1453:doi
1418:doi
1385:doi
1353:doi
1349:273
1318:PMC
1310:doi
1306:326
1277:doi
1273:350
1194:doi
1156:doi
1152:272
288:End
187:End
90:OMA
66:MGI
2152::
1938::
1739:EC
1733::
1686:.
1674:.
1657:.
1649:.
1637:28
1635:.
1631:.
1614:.
1604:.
1594:92
1592:.
1588:.
1571:.
1559:.
1542:.
1532:.
1522:89
1520:.
1516:.
1499:.
1491:.
1481:22
1479:.
1461:.
1449:88
1447:.
1443:.
1426:.
1414:31
1412:.
1408:.
1391:.
1381:84
1379:.
1361:.
1347:.
1343:.
1326:.
1316:.
1304:.
1300:.
1283:.
1271:.
1214:^
1200:.
1190:16
1188:.
1164:.
1150:.
1146:.
1127:.
1109:.
1080:^
1059:^
1023:.
1008:sn
667:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
2138:e
2131:t
2124:v
2113:.
1842::
1760::
1737:(
1723:e
1716:t
1709:v
1694:.
1682::
1665:.
1643::
1622:.
1600::
1579:.
1567::
1550:.
1528::
1507:.
1487::
1469:.
1455::
1434:.
1420::
1399:.
1387::
1369:.
1355::
1334:.
1312::
1291:.
1279::
1255:.
1225:.
1208:.
1196::
1172:.
1158::
1131:.
1113:.
1033:O
212:)
109:)
92::
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