310:
287:
184:
209:
568:
561:
316:
215:
29:
2167:
1298:
have been found for this gene, but only one of them has been fully characterized. It lacks an external amphipathic motif and is uniquely secreted to plasma without cleavage of its terminal signal peptide. The average molecular weight is 21253 Da, and the monoisotopic molecular weight is 21239 Da.
55:
1939:
Niu N, Zhu X, Liu Y, Du T, Wang X, Chen D, et al. (January 2007). "Single nucleotide polymorphisms in the proximal promoter region of apolipoprotein M gene (apoM) confer the susceptibility to development of type 2 diabetes in Han
Chinese".
1548:
Albertella MR, Jones H, Thomson W, Olavesen MG, Campbell RD (September 1996). "Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B)".
1321:
ENSG00000204444, ENSG00000206409, ENSG00000227567, ENSG00000235754, ENSG00000224290, ENSG00000226215 GRCh38: Ensembl release 89: ENSG00000231974, ENSG00000204444, ENSG00000206409, ENSG00000227567, ENSG00000235754, ENSG00000224290,
1578:
Xu N, Zhang XY, Dong X, Ekström U, Ye Q, Nilsson-Ehle P (April 2002). "Effects of platelet-activating factor, tumor necrosis factor, and interleukin-1alpha on the expression of apolipoprotein M in HepG2 cells".
1661:
Zhang XY, Dong X, Zheng L, Luo GH, Liu YH, Ekström U, et al. (2003). "Specific tissue expression and cellular localization of human apolipoprotein M as determined by in situ hybridization".
1797:
Kabbara A, Payet N, Cottel D, Frigard B, Amouyel P, Lambert JC (June 2004). "Exclusion of CYP46 and APOM as candidate genes for
Alzheimer's disease in a French population".
1692:"Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels"
323:
222:
1209:
2041:
Xu X, Ye Q, Xu N, He X, Luo G, Zhang X, et al. (November 2006). "Effects of ischemia-reperfusion injury on apolipoprotein M expression in the liver".
1768:
Zhang XY, Jiao GQ, Hurtig M, Dong X, Zheng L, Luo GH, et al. (2005). "Expression pattern of apolipoprotein M during mouse and human embryogenesis".
826:
807:
145:
2236:
2212:
1377:
1359:
2231:
2012:
Karlsson H, Lindqvist H, Tagesson C, Lindahl M (October 2006). "Characterization of apolipoprotein M isoforms in low-density lipoprotein".
1834:
Xu N, Nilsson-Ehle P, Ahrén B (October 2004). "Correlation of apolipoprotein M with leptin and cholesterol in normal and obese subjects".
309:
2118:
1067:
1060:
286:
1488:
1504:"The signal peptide anchors apolipoprotein M in plasma lipoproteins and prevents rapid clearance of apolipoprotein M from plasma"
1346:
1325:
1342:
1229:
208:
183:
52:
2124:
1320:
125:
322:
221:
2205:
1898:"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry"
315:
214:
1291:
1263:
897:
133:
1217:
2112:
1267:
878:
874:
864:
860:
856:
852:
848:
1727:"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse"
1865:"Leptin inhibits apolipoprotein M transcription and secretion in human hepatoma cell line, HepG2 cells"
1608:
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002).
1213:
2198:
1621:
1287:
197:
112:
1438:"Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis"
2130:
1018:
967:
1965:
1822:
1467:
157:
1690:
Richter S, Shih DQ, Pearson ER, Wolfrum C, Fajans SS, Hattersley AT, Stoffel M (December 2003).
1610:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
1043:
1022:
992:
971:
2137:
2093:
2058:
2029:
2000:
1957:
1927:
1884:
1851:
1814:
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1713:
1678:
1649:
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1525:
1459:
1418:
1204:
105:
45:
2182:
2083:
2050:
2021:
1990:
1949:
1917:
1909:
1876:
1843:
1806:
1777:
1746:
1738:
1703:
1670:
1639:
1629:
1588:
1558:
1515:
1449:
1408:
567:
560:
402:
333:
277:
232:
1502:
Christoffersen C, Ahnström J, Axler O, Christensen EI, Dahlbäck B, Nielsen LB (July 2008).
1196:
1977:
Christoffersen C, Nielsen LB, Axler O, Andersson A, Johnsen AH, Dahlbäck B (August 2006).
1283:
377:
153:
1625:
2054:
1922:
1897:
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1245:
1751:
1726:
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28:
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2146:
596:
1969:
1826:
1471:
1145:
137:
2178:
1271:
1192:
395:
174:
1979:"Isolation and characterization of human apolipoprotein M-containing lipoproteins"
1847:
1725:
Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, et al. (December 2003).
1158:
1880:
1810:
1781:
1170:
161:
1708:
1691:
1382:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1364:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1275:
2088:
2072:"Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M"
2071:
1995:
1978:
1614:
Proceedings of the
National Academy of Sciences of the United States of America
478:
294:
191:
141:
1896:
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006).
1413:
1396:
1674:
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771:
538:
416:
361:
348:
260:
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149:
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2004:
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1600:
1592:
1562:
1529:
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1503:
1463:
1422:
1869:
Biochimica et
Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
1570:
1107:
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838:
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1913:
1864:
82:
78:
74:
1953:
1224:
1075:
793:
2166:
756:
752:
2174:
1259:
1186:
1152:
1140:
576:
129:
2136:
Overview of all the structural information available in the
1863:
Luo G, Hurtig M, Zhang X, Nilsson-Ehle P, Xu N (May 2005).
2070:
Ahnström J, Faber K, Axler O, Dahlbäck B (August 2007).
385:
2186:
550:
1286:
but remains membrane-bound, where it is involved in
1581:
1223:
1203:
1185:
1180:
1164:
1151:
1139:
1131:
1126:
1121:
1036:
1011:
985:
960:
697:
negative regulation of plasma lipoprotein oxidation
1338:
1336:
1334:
1316:
1314:
1312:
332:
231:
1436:Duan J, Dahlbäck B, Villoutreix BO (June 2001).
16:Protein-coding gene in the species Homo sapiens
1343:GRCm38: Ensembl release 89: ENSMUSG00000024391
2206:
116:, G3a, HSPC336, NG20, apo-M, apolipoprotein M
8:
717:high-density lipoprotein particle remodeling
737:high-density lipoprotein particle clearance
651:spherical high-density lipoprotein particle
636:discoidal high-density lipoprotein particle
2213:
2199:
1177:
843:
767:
707:high-density lipoprotein particle assembly
592:
373:
272:
169:
63:
2087:
1994:
1921:
1750:
1707:
1643:
1633:
1519:
1453:
1412:
517:fetal liver hematopoietic progenitor cell
1942:Diabetes/Metabolism Research and Reviews
1483:
1481:
1836:The Journal of Nutritional Biochemistry
1308:
1118:
18:
1397:"A novel human apolipoprotein (apoM)"
646:very-low-density lipoprotein particle
641:integral component of plasma membrane
337:
298:
293:
236:
195:
190:
7:
2163:
2161:
1489:"Entrez Gene: APOM apolipoprotein M"
1508:The Journal of Biological Chemistry
1401:The Journal of Biological Chemistry
2185:. You can help Knowledge (XXG) by
2055:10.1016/j.transproceed.2006.08.133
1033:
1008:
982:
957:
933:
914:
888:
817:
798:
555:
473:
411:
390:
14:
1395:Xu N, Dahlbäck B (October 1999).
1255:that in humans is encoded by the
666:high-density lipoprotein particle
2165:
2150:(Human Apolipoprotein M) at the
1294:variants encoding two different
661:low-density lipoprotein particle
566:
559:
321:
314:
308:
285:
220:
213:
207:
182:
27:
742:cellular oxidant detoxification
1262:. It is found associated with
577:More reference expression data
539:More reference expression data
455:olfactory zone of nasal mucosa
1:
2237:Human chromosome 6 gene stubs
1848:10.1016/j.jnutbio.2004.03.001
1455:10.1016/S0014-5793(01)02544-3
1181:Available protein structures:
732:reverse cholesterol transport
687:lipoprotein metabolic process
306:
205:
2014:Journal of Proteome Research
1902:Journal of Proteome Research
1881:10.1016/j.bbalip.2005.02.005
1811:10.1016/j.neulet.2004.03.066
1782:10.1016/j.acthis.2003.11.004
1266:and to a lesser extent with
2232:Genes on human chromosome 6
2043:Transplantation Proceedings
1709:10.2337/diabetes.52.12.2989
2253:
2160:
2129:gene details page in the
2089:10.1194/jlr.M700103-JLR200
1996:10.1194/jlr.M600055-JLR200
712:retinoid metabolic process
610:lipid transporter activity
2076:Journal of Lipid Research
1983:Journal of Lipid Research
1378:"Mouse PubMed Reference:"
1360:"Human PubMed Reference:"
1278:. The encoded protein is
1264:high density lipoproteins
1176:
1106:
1101:
1097:
1090:
1074:
1055:
1040:
1015:
1004:
989:
964:
953:
940:
936:
921:
917:
908:
895:
891:
872:
846:
837:
824:
820:
805:
801:
792:
777:
770:
766:
750:
595:
591:
574:
558:
549:
536:
485:
476:
423:
414:
384:
376:
372:
355:
342:
305:
284:
275:
271:
254:
241:
204:
181:
172:
168:
123:
120:
110:
103:
98:
71:
66:
49:
44:
39:
35:
26:
21:
2113:Applied Research on apoM
1414:10.1074/jbc.274.44.31286
1268:low density lipoproteins
1068:Chr 17: 35.35 – 35.35 Mb
1675:10.1078/0065-1281-00687
1061:Chr 6: 31.65 – 31.66 Mb
727:cholesterol homeostasis
1635:10.1073/pnas.242603899
1593:10.1006/bbrc.2002.6755
1563:10.1006/geno.1996.0459
1521:10.1074/jbc.M800695200
300:Chromosome 17 (mouse)
2123:genome location and
1799:Neuroscience Letters
656:extracellular region
620:phospholipid binding
615:antioxidant activity
459:gastrocnemius muscle
198:Chromosome 6 (human)
67:List of PDB id codes
40:Available structures
2131:UCSC Genome Browser
1626:2002PNAS...9916899M
1620:(26): 16899–16903.
1514:(27): 18765–18772.
1407:(44): 31286–31290.
702:response to glucose
671:extracellular space
427:right lobe of liver
2173:This article on a
1743:10.1101/gr.1736803
1248:and member of the
898:ENSMUSG00000024391
722:cholesterol efflux
680:Biological process
629:Cellular component
603:Molecular function
493:left lobe of liver
2194:
2193:
2026:10.1021/pr060180x
2020:(10): 2685–2690.
1914:10.1021/pr0502065
1770:Acta Histochemica
1737:(12): 2621–2636.
1702:(12): 2989–2995.
1663:Acta Histochemica
1239:
1238:
1235:
1234:
1230:structure summary
1117:
1116:
1113:
1112:
1086:
1085:
1051:
1050:
1030:
1029:
1000:
999:
979:
978:
949:
948:
930:
929:
904:
903:
885:
884:
833:
832:
814:
813:
762:
761:
587:
586:
583:
582:
545:
544:
532:
531:
470:
469:
368:
367:
267:
266:
94:
93:
90:
89:
50:Ortholog search:
2244:
2215:
2208:
2201:
2169:
2162:
2101:
2091:
2082:(8): 1754–1762.
2066:
2049:(9): 2769–2773.
2037:
2008:
1998:
1989:(8): 1833–1843.
1973:
1954:10.1002/dmrr.641
1935:
1925:
1908:(6): 2070–2080.
1892:
1859:
1830:
1793:
1764:
1754:
1721:
1711:
1686:
1657:
1647:
1637:
1604:
1574:
1534:
1533:
1523:
1499:
1493:
1492:
1485:
1476:
1475:
1457:
1448:(1–2): 127–132.
1433:
1427:
1426:
1416:
1392:
1386:
1385:
1374:
1368:
1367:
1356:
1350:
1340:
1329:
1318:
1242:Apolipoprotein M
1178:
1119:
1099:
1098:
1070:
1063:
1046:
1034:
1025:
1009:
1005:RefSeq (protein)
995:
983:
974:
958:
934:
915:
889:
868:
844:
818:
799:
768:
593:
579:
570:
563:
556:
541:
513:primitive streak
481:
479:Top expressed in
474:
419:
417:Top expressed in
412:
391:
374:
364:
351:
340:
325:
318:
312:
301:
289:
273:
263:
250:
239:
224:
217:
211:
200:
186:
170:
164:
162:APOM - orthologs
115:
108:
85:
64:
58:
37:
36:
31:
19:
2252:
2251:
2247:
2246:
2245:
2243:
2242:
2241:
2222:
2221:
2220:
2219:
2158:
2109:
2104:
2069:
2040:
2011:
1976:
1938:
1895:
1862:
1842:(10): 579–582.
1833:
1796:
1767:
1731:Genome Research
1724:
1689:
1660:
1607:
1577:
1547:
1543:
1541:Further reading
1538:
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1394:
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1389:
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1371:
1358:
1357:
1353:
1341:
1332:
1322:ENSG00000226215
1319:
1310:
1305:
1288:lipid transport
1284:plasma membrane
1108:View/Edit Mouse
1103:View/Edit Human
1066:
1059:
1056:Location (UCSC)
1042:
1021:
1017:
991:
970:
966:
879:ENSG00000226215
877:
875:ENSG00000224290
867:
865:ENSG00000235754
863:
861:ENSG00000227567
859:
857:ENSG00000206409
855:
853:ENSG00000204444
851:
849:ENSG00000231974
847:
746:
692:lipid transport
675:
624:
575:
565:
564:
537:
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519:
515:
511:
509:proximal tubule
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276:Gene location (
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173:Gene location (
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2107:External links
2105:
2103:
2102:
2067:
2038:
2009:
1974:
1936:
1893:
1875:(2): 198–202.
1860:
1831:
1805:(2): 139–143.
1794:
1776:(2): 123–128.
1765:
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1587:(4): 944–950.
1575:
1557:(2): 240–251.
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1253:protein family
1246:apolipoprotein
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1882:
1878:
1874:
1870:
1866:
1861:
1857:
1853:
1849:
1845:
1841:
1837:
1832:
1828:
1824:
1820:
1816:
1812:
1808:
1804:
1800:
1795:
1791:
1787:
1783:
1779:
1775:
1771:
1766:
1762:
1758:
1753:
1748:
1744:
1740:
1736:
1732:
1728:
1723:
1719:
1715:
1710:
1705:
1701:
1697:
1693:
1688:
1684:
1680:
1676:
1672:
1668:
1664:
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1655:
1651:
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1641:
1636:
1631:
1627:
1623:
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1615:
1611:
1606:
1602:
1598:
1594:
1590:
1586:
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1576:
1572:
1568:
1564:
1560:
1556:
1552:
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1531:
1527:
1522:
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1509:
1505:
1498:
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1490:
1484:
1482:
1478:
1473:
1469:
1465:
1461:
1456:
1451:
1447:
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1439:
1432:
1429:
1424:
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1415:
1410:
1406:
1402:
1398:
1391:
1388:
1383:
1379:
1373:
1370:
1365:
1361:
1355:
1352:
1348:
1344:
1339:
1337:
1335:
1331:
1327:
1323:
1317:
1315:
1313:
1309:
1302:
1300:
1297:
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1289:
1285:
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1277:
1273:
1269:
1265:
1261:
1258:
1254:
1251:
1247:
1243:
1231:
1228:
1226:
1222:
1219:
1215:
1211:
1208:
1206:
1202:
1198:
1194:
1191:
1188:
1184:
1179:
1175:
1172:
1169:
1167:
1163:
1160:
1157:
1154:
1150:
1147:
1144:
1142:
1138:
1134:
1130:
1125:
1120:
1109:
1104:
1100:
1096:
1093:
1089:
1082:
1080:
1077:
1073:
1069:
1065:
1062:
1058:
1054:
1047:
1045:
1039:
1035:
1032:
1026:
1024:
1020:
1014:
1010:
1007:
1003:
996:
994:
988:
984:
981:
975:
973:
969:
963:
959:
956:
954:RefSeq (mRNA)
952:
945:
944:
939:
935:
932:
926:
925:
920:
916:
913:
911:
907:
900:
899:
894:
890:
887:
881:
880:
876:
871:
866:
862:
858:
854:
850:
845:
842:
840:
836:
829:
828:
823:
819:
816:
810:
809:
804:
800:
797:
795:
791:
788:
785:
783:
780:
776:
773:
769:
765:
758:
754:
749:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
713:
710:
708:
705:
703:
700:
698:
695:
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690:
688:
685:
684:
682:
679:
678:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
647:
644:
642:
639:
637:
634:
633:
631:
628:
627:
621:
618:
616:
613:
611:
608:
607:
605:
602:
601:
598:
597:Gene ontology
594:
590:
578:
573:
569:
562:
557:
554:
552:
548:
540:
535:
524:
520:
516:
512:
508:
504:
500:
496:
492:
488:
487:
484:
480:
475:
472:
462:
458:
454:
450:
446:
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438:
434:
430:
426:
425:
422:
418:
413:
410:
409:
406:
404:
400:
398:
397:
393:
392:
389:
387:
383:
379:
375:
371:
363:
358:
354:
350:
345:
339:17|17 B1
335:
331:
324:
317:
311:
304:
296:
292:
288:
283:
279:
274:
270:
262:
257:
253:
249:
244:
234:
230:
223:
216:
210:
203:
199:
193:
189:
185:
180:
176:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
119:
114:
107:
102:
97:
86:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
2187:expanding it
2179:chromosome 6
2172:
2157:
2145:
2125:
2119:
2079:
2075:
2046:
2042:
2017:
2013:
1986:
1982:
1948:(1): 21–25.
1945:
1941:
1905:
1901:
1872:
1868:
1839:
1835:
1802:
1798:
1773:
1769:
1734:
1730:
1699:
1695:
1669:(1): 67–72.
1666:
1662:
1617:
1613:
1584:
1580:
1554:
1550:
1511:
1507:
1497:
1445:
1442:FEBS Letters
1441:
1431:
1404:
1400:
1390:
1381:
1372:
1363:
1354:
1282:through the
1276:lipoproteins
1272:triglyceride
1256:
1241:
1240:
1041:
1019:NP_001243098
1016:
990:
968:NM_001256169
965:
941:
922:
896:
873:
825:
806:
786:
781:
505:human kidney
497:right kidney
451:right testis
439:renal cortex
431:human kidney
401:
394:
121:External IDs
72:
1127:Identifiers
501:human fetus
463:bone marrow
447:left testis
360:35,351,026
347:35,347,973
259:31,658,210
246:31,652,416
99:Identifiers
2226:Categories
1349:, May 2017
1328:, May 2017
1303:References
1292:transcript
1193:structures
525:blastocyst
405:(ortholog)
142:HomoloGene
2177:on human
1250:lipocalin
1171:IPR022734
1044:NP_061286
1023:NP_061974
993:NM_018816
972:NM_019101
772:Orthologs
150:GeneCards
2098:17525477
2063:17112825
2034:17022639
2005:16682745
1970:21156244
1962:16572495
1932:16335952
1889:15904876
1856:15542348
1827:27752858
1819:15172102
1790:15147633
1761:14656967
1718:14633861
1696:Diabetes
1683:12666989
1654:12477932
1601:11944906
1551:Genomics
1530:18460466
1472:28493816
1464:11418126
1423:10531326
1345:–
1324:–
1296:isoforms
1280:secreted
1210:RCSB PDB
1166:InterPro
1092:Wikidata
751:Sources:
489:yolk sac
443:testicle
2152:PDBe-KB
2142:UniProt
1923:1850943
1622:Bibcode
1571:8812450
1347:Ensembl
1326:Ensembl
1146:PF11032
910:UniProt
839:Ensembl
778:Species
757:QuickGO
380:pattern
238:6p21.33
138:1930124
106:Aliases
2147:O95445
2117:Human
2096:
2061:
2032:
2003:
1968:
1960:
1930:
1920:
1887:
1854:
1825:
1817:
1788:
1759:
1752:403804
1749:
1716:
1681:
1652:
1645:139241
1642:
1599:
1569:
1528:
1470:
1462:
1421:
1290:. Two
1274:-rich
1244:is an
1225:PDBsum
1199:
1189:
1159:CL0116
1132:Symbol
1078:search
1076:PubMed
943:Q9Z1R3
924:O95445
794:Entrez
551:BioGPS
130:606907
2181:is a
1966:S2CID
1823:S2CID
1468:S2CID
827:55938
808:55937
787:Mouse
782:Human
753:Amigo
435:gonad
403:Mouse
396:Human
343:Start
278:Mouse
242:Start
175:Human
146:10308
2183:stub
2175:gene
2140:for
2126:APOM
2120:APOM
2094:PMID
2059:PMID
2030:PMID
2001:PMID
1958:PMID
1928:PMID
1885:PMID
1873:1734
1852:PMID
1815:PMID
1786:PMID
1757:PMID
1714:PMID
1679:PMID
1650:PMID
1597:PMID
1567:PMID
1526:PMID
1460:PMID
1419:PMID
1270:and
1260:gene
1257:APOM
1218:PDBj
1214:PDBe
1197:ECOD
1187:Pfam
1155:clan
1153:Pfam
1141:Pfam
1135:ApoM
1122:ApoM
386:Bgee
334:Band
295:Chr.
233:Band
192:Chr.
154:APOM
126:OMIM
113:APOM
83:2YG2
79:2WEX
75:2WEW
56:RCSB
53:PDBe
22:APOM
2138:PDB
2084:doi
2051:doi
2022:doi
1991:doi
1950:doi
1918:PMC
1910:doi
1877:doi
1844:doi
1807:doi
1803:363
1778:doi
1774:106
1747:PMC
1739:doi
1704:doi
1671:doi
1667:105
1640:PMC
1630:doi
1589:doi
1585:292
1559:doi
1516:doi
1512:283
1450:doi
1446:499
1409:doi
1405:274
1205:PDB
356:End
255:End
158:OMA
134:MGI
46:PDB
2228::
2144::
2092:.
2080:48
2078:.
2074:.
2057:.
2047:38
2045:.
2028:.
2016:.
1999:.
1987:47
1985:.
1981:.
1964:.
1956:.
1946:23
1944:.
1926:.
1916:.
1904:.
1900:.
1883:.
1871:.
1867:.
1850:.
1840:15
1838:.
1821:.
1813:.
1801:.
1784:.
1772:.
1755:.
1745:.
1735:13
1733:.
1729:.
1712:.
1700:52
1698:.
1694:.
1677:.
1665:.
1648:.
1638:.
1628:.
1618:99
1616:.
1612:.
1595:.
1583:.
1565:.
1555:36
1553:.
1524:.
1510:.
1506:.
1480:^
1466:.
1458:.
1444:.
1440:.
1417:.
1403:.
1399:.
1380:.
1362:.
1333:^
1311:^
1216:;
1212:;
1195:/
755:/
362:bp
349:bp
261:bp
248:bp
156:;
152::
148:;
144::
140:;
136::
132:;
128::
81:,
77:,
2214:e
2207:t
2200:v
2189:.
2154:.
2133:.
2100:.
2086::
2065:.
2053::
2036:.
2024::
2018:5
2007:.
1993::
1972:.
1952::
1934:.
1912::
1906:4
1891:.
1879::
1858:.
1846::
1829:.
1809::
1792:.
1780::
1763:.
1741::
1720:.
1706::
1685:.
1673::
1656:.
1632::
1624::
1603:.
1591::
1573:.
1561::
1532:.
1518::
1491:.
1474:.
1452::
1425:.
1411::
1384:.
1366:.
280:)
177:)
160::
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