167:
192:
198:
3032:
2284:
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K,
1938:
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999).
50:
908:
A3C belong to the A3 family of cytidine deaminases that act as restriction factors against diverse retroviruses. A3C was reported to inhibit simian immunodeficiency deficiency virus potently rather than HIV-1, in absence of viral infectivity factor,
1572:
Ayyappan Jaguva
Vasudevan, Ananda; Balakrishnan, Kannan; G. W. Gertzen, Christoph; Borvető, Fanni; Zhang, Zeli; Sangwiman, Anucha; Held, Ulrike; Küstermann, Caroline; Banerjee, Sharmistha; Schumann, Gerald G.; Häussinger, Dieter (October 2020).
1620:
Kitamura S, Ode H, Nakashima M, Imahashi M, Naganawa Y, Kurosawa T, Yokomaku Y, Yamane T, Watanabe N, Suzuki A, Sugiura W, Iwatani Y (October 2012). "The APOBEC3C crystal structure and the interface for HIV-1 Vif binding".
2440:
948:. Conversely, A3 proteins enzymatically convert cytidine to uridine present in the single stranded DNA. Two residues in loop 1 of A3C were demonstrated to determine its antiviral activity against HIV-1.
1363:
Yu Q, König R, Pillai S, Chiles K, Kearney M, Palmer S, Richman D, Coffin JM, Landau NR (May 2004). "Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome".
1105:
Jaguva
Vasudevan AA, Hofmann H, Willbold D, Häussinger D, Koenig BW, Münk C (April 2017). "Enhancing the Catalytic Deamination Activity of APOBEC3C Is Insufficient to Inhibit Vif-Deficient HIV-1".
913:. Enhancing A3C's catalytic activity had only a marginal effect on HIV-1 replication (in absence of Vif), the counteractive viral mechanism is unclear. A3C was also shown to inhibit other viruses.
1314:
Ahasan MM, Wakae K, Wang Z, Kitamura K, Liu G, Koura M, Imayasu M, Sakamoto N, Hanaoka K, Nakamura M, Kyo S, Kondo S, Fujiwara H, Yoshizaki T, Mori S, Kukimoto I, Muramatsu M (February 2015).
1447:
Harris RS, Sheehy AM, Craig HM, Malim MH, Neuberger MS (July 2003). "DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses".
1713:
Horn AV, Klawitter S, Held U, Berger A, Vasudevan AA, Bock A, Hofmann H, Hanschmann KM, Trösemeier JH, Flory E, Jabulowsky RA, Han JS, Löwer J, Löwer R, Münk C, Schumann GG (January 2014).
2099:"Mutational comparison of the single-domained APOBEC3C and double-domained APOBEC3F/G anti-retroviral cytidine deaminases provides insight into their DNA target site specificities"
1015:
Jarmuz A, Chester A, Bayliss J, Gisbourne J, Dunham I, Scott J, Navaratnam N (March 2002). "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22".
2433:
1315:
205:
2426:
1766:
Wedekind JE, Dance GS, Sowden MP, Smith HC (April 2003). "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business".
1903:
Madsen P, Anant S, Rasmussen HH, Gromov P, Vorum H, Dumanski JP, Tommerup N, Collins JE, Wright CL, Dunham I, MacGinnitie AJ, Davidson NO, Celis JE (August 1999).
1664:
Zhang Z, Gu Q, Jaguva
Vasudevan AA, Jeyaraj M, Schmidt S, Zielonka J, Perković M, Heckel JO, Cichutek K, Häussinger D, Smits SH, Münk C (November 2016).
128:
625:
1715:"Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity"
2220:
Rose KM, Marin M, Kozak SL, Kabat D (July 2005). "Regulated production and anti-HIV type 1 activities of cytidine deaminases APOBEC3B, 3F, and 3G".
2017:
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005).
2140:
Pope SN, Lee IR (February 2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin".
3052:
2669:
1279:
Li D, Liu J, Kang F, Guan W, Gao X, Wang Y, Sun D (October 2011). "Core-APOBEC3C chimerical protein inhibits hepatitis B virus replication".
997:
1191:"Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo"
2379:
834:
944:. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase
2751:
957:
1666:"Vif Proteins from Diverse Human Immunodeficiency Virus/Simian Immunodeficiency Virus Lineages Have Distinct Binding Sites in A3C"
1050:
984:
2385:
2644:
1189:
Suspène R, Aynaud MM, Koch S, Pasdeloup D, Labetoulle M, Gaertner B, Vartanian JP, Meyerhans A, Wain-Hobson S (August 2011).
191:
166:
2907:
3022:
980:
1905:"Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1"
204:
116:
197:
1982:
Mariani R, Chen D, Schröfelbauer B, Navarro F, König R, Bollman B, Münk C, Nymark-McMahon H, Landau NR (July 2003).
2606:
2892:
2179:"Differential sensitivity of murine leukemia virus to APOBEC3-mediated inhibition is governed by virion exclusion"
3008:
2995:
2982:
2969:
2956:
2943:
2930:
2704:
2681:
2616:
2583:
2550:
2462:
1882:
Haché G, Mansky LM, Harris RS (2006). "Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance".
2902:
2856:
2799:
2453:
910:
2249:
Muckenfuss H, Hamdorf M, Held U, Perkovic M, Löwer J, Cichutek K, Flory E, Schumann GG, Münk C (August 2006).
107:, A3C, APOBEC1L, ARDC2, ARDC4, ARP5, PBI, bK150C2.3, apolipoprotein B mRNA editing enzyme catalytic subunit 3C
47:
2804:
2523:
668:
1490:
Harris RS, Bishop KN, Sheehy AM, Craig HM, Petersen-Mahrt SK, Watt IN, Neuberger MS, Malim MH (June 2003).
2825:
2744:
180:
2897:
2654:
1952:
103:
1839:
956:
The crystal structure of A3C suggests a putative HIV-1 vif binding region. A3C was found to inhibit
2861:
2634:
2533:
2418:
2391:
2794:
2659:
2165:
1870:
1646:
1602:
1574:
1472:
1388:
1171:
922:
555:
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
140:
798:
753:
3057:
2629:
2398:
2359:
2316:
2272:
2237:
2208:
2157:
2128:
2085:
2050:
2005:
1970:
1926:
1891:
1862:
1826:
1783:
1744:
1695:
1638:
1594:
1554:
1513:
1464:
1429:
1380:
1345:
1296:
1261:
1220:
1163:
1122:
1087:
1032:
136:
96:
40:
2285:
Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007).
2840:
2835:
2809:
2737:
2349:
2341:
2306:
2298:
2262:
2229:
2198:
2190:
2149:
2118:
2110:
2075:
2040:
2030:
1995:
1960:
1916:
1854:
1816:
1808:
1775:
1734:
1726:
1685:
1677:
1630:
1586:
1544:
1503:
1456:
1419:
1372:
1335:
1327:
1288:
1251:
1210:
1202:
1153:
1114:
1077:
1024:
937:
284:
215:
2328:
Kinomoto M, Kanno T, Shimura M, Ishizaka Y, Kojima A, Kurata T, Sata T, Tokunaga K (2007).
1051:"Entrez Gene: APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C"
2887:
2871:
2784:
2511:
2064:"APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication"
1533:"APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication"
1066:"APOBEC3B and APOBEC3C are potent inhibitors of simian immunodeficiency virus replication"
933:
259:
1797:"Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factors"
960:
elements by directly interacting with ORF1p proteins, in a deaminase-independent manner.
438:
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
1956:
3036:
2925:
2866:
2686:
2649:
2621:
2573:
2568:
2555:
2505:
2467:
2354:
2329:
2311:
2286:
2203:
2178:
2123:
2098:
1821:
1796:
1739:
1714:
1690:
1665:
1215:
1190:
1142:"Hepatitis B virus DNA is subject to extensive editing by the human deaminase APOBEC3C"
2045:
2018:
2000:
1983:
1779:
1508:
1491:
1424:
1407:
559:
554:
549:
544:
539:
534:
529:
524:
519:
514:
509:
493:
488:
483:
467:
462:
457:
452:
447:
437:
432:
3046:
2830:
2789:
2713:
2639:
2588:
2407:
2194:
1921:
1904:
1606:
941:
419:
1838:
Vasudevan AA, Smits SH, Höppner A, Häussinger D, Koenig BW, Münk C (November 2013).
1812:
1392:
2779:
2495:
2475:
2169:
1874:
1650:
1476:
1175:
277:
157:
144:
3003:
2938:
2774:
2563:
2490:
2480:
2287:"Large-scale mapping of human protein-protein interactions by mass spectrometry"
2153:
1002:
National Center for
Biotechnology Information, U.S. National Library of Medicine
925:
3031:
1331:
1240:"Hypermutation of hepatitis B virus genomes by APOBEC3G, APOBEC3C and APOBEC3H"
2718:
2601:
2518:
2330:"All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition"
1590:
1118:
929:
174:
124:
2035:
1408:"RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators"
2977:
2951:
2694:
2449:
2233:
589:
377:
298:
243:
230:
132:
2363:
2320:
2276:
2267:
2250:
2241:
2212:
2161:
2132:
2089:
2080:
2063:
2054:
2009:
1974:
1930:
1895:
1866:
1830:
1787:
1748:
1699:
1642:
1598:
1558:
1549:
1532:
1517:
1468:
1433:
1384:
1349:
1316:"APOBEC3A and 3C decrease human papillomavirus 16 pseudovirion infectivity"
1300:
1265:
1224:
1167:
1126:
1091:
1082:
1065:
1036:
1028:
1858:
1256:
1239:
877:
2596:
2345:
2114:
1730:
1681:
1206:
866:
711:
2062:
Yu Q, Chen D, König R, Mariani R, Unutmaz D, Landau NR (December 2004).
1531:
Yu Q, Chen D, König R, Mariani R, Unutmaz D, Landau NR (December 2004).
1292:
1064:
Yu Q, Chen D, König R, Mariani R, Unutmaz D, Landau NR (December 2004).
442:
2538:
2412:
2402:
2302:
1460:
945:
895:
697:
654:
1634:
1340:
1158:
1141:
73:
69:
2990:
2760:
2485:
847:
611:
2177:
Doehle BP, Schäfer A, Wiegand HL, Bogerd HP, Cullen BR (July 2005).
1376:
1965:
1940:
1575:"Loop 1 of APOBEC3C regulates its antiviral activity against HIV-1"
1140:
Baumert TF, Rösler C, Malim MH, von Weizsäcker F (September 2007).
2964:
2664:
2019:"A genome annotation-driven approach to cloning the human ORFeome"
1984:"Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif"
1492:"DNA deamination mediates innate immunity to retroviral infection"
574:
570:
2528:
2500:
902:
120:
2733:
2422:
2397:
Overview of all the structural information available in the
1406:
Harris RS, Petersen-Mahrt SK, Neuberger MS (November 2002).
2097:
Langlois MA, Beale RC, Conticello SG, Neuberger MS (2005).
2729:
2251:"APOBEC3 proteins inhibit human LINE-1 retrotransposition"
1840:"Structural features of antiviral DNA cytidine deaminases"
2142:
The
Journal of Steroid Biochemistry and Molecular Biology
267:
3020:
389:
2916:
2880:
2849:
2818:
2767:
2703:
2680:
2615:
2582:
2549:
2461:
1320:
812:
791:
767:
746:
976:
974:
972:
2411:( DNA dC->dU-editing enzyme APOBEC-3C) at the
214:
510:negative regulation of viral genome replication
2745:
2434:
8:
981:GRCh38: Ensembl release 89: ENSG00000244509
2752:
2738:
2730:
2441:
2427:
2419:
585:
415:
255:
152:
58:
2353:
2310:
2266:
2202:
2122:
2079:
2044:
2034:
1999:
1964:
1941:"The DNA sequence of human chromosome 22"
1920:
1820:
1738:
1689:
1623:Nature Structural & Molecular Biology
1548:
1507:
1423:
1365:Nature Structural & Molecular Biology
1339:
1255:
1214:
1157:
1081:
1909:The Journal of Investigative Dermatology
3027:
968:
928:. It is one of seven related genes or
892:DNA dC->dU-editing enzyme APOBEC-3C
18:
2670:Activation-induced cytidine deaminase
219:
178:
173:
7:
2222:AIDS Research and Human Retroviruses
540:negative regulation of transposition
2255:The Journal of Biological Chemistry
2068:The Journal of Biological Chemistry
1537:The Journal of Biological Chemistry
1070:The Journal of Biological Chemistry
809:
788:
764:
743:
721:
702:
678:
659:
635:
616:
394:
355:
293:
272:
14:
898:that in humans is encoded by the
3030:
2195:10.1128/JVI.79.13.8201-8207.2005
1922:10.1046/j.1523-1747.1999.00682.x
203:
196:
190:
165:
2452:: carbon-nitrogen non-peptide (
1813:10.1128/JVI.80.3.1067-1076.2006
1244:The Journal of General Virology
2645:Inosine monophosphate synthase
378:More reference expression data
1:
2001:10.1016/S0092-8674(03)00515-4
1780:10.1016/S0168-9525(03)00054-4
1509:10.1016/s0092-8674(03)00423-9
1425:10.1016/s1097-2765(02)00742-6
921:This gene is a member of the
188:
16:Protein-coding gene in humans
3053:Genes on human chromosome 22
1579:Journal of Molecular Biology
1238:Köck J, Blum HE (May 2008).
1107:Journal of Molecular Biology
2154:10.1016/j.jsbmb.2005.01.007
1795:Cullen BR (February 2006).
550:cytidine to uridine editing
468:cytidine deaminase activity
341:stromal cell of endometrium
3074:
2607:Protein-arginine deiminase
2529:Fatty acid amide hydrolase
2390:gene details page in the
1332:10.1016/j.bbrc.2014.12.103
2908:Michaelis–Menten kinetics
2291:Molecular Systems Biology
1591:10.1016/j.jmb.2020.10.014
1119:10.1016/j.jmb.2017.03.015
998:"Human PubMed Reference:"
881:
876:
872:
865:
846:
829:
816:
795:
784:
771:
750:
739:
728:
724:
709:
705:
696:
685:
681:
666:
662:
653:
642:
638:
623:
619:
610:
595:
588:
584:
568:
520:defense response to virus
418:
414:
402:
397:
388:
375:
362:
358:
305:
296:
266:
258:
254:
237:
224:
187:
164:
155:
151:
114:
111:
101:
94:
89:
66:
61:
44:
39:
34:
30:
26:
21:
2800:Diffusion-limited enzyme
2036:10.1186/gb-2004-5-10-r84
835:Chr 22: 39.01 – 39.02 Mb
560:DNA cytosine deamination
2524:Aspartylglucosaminidase
2234:10.1089/aid.2005.21.611
1281:Journal of Biochemistry
936:thought to result from
2334:Nucleic Acids Research
2268:10.1074/jbc.M601716200
2103:Nucleic Acids Research
2081:10.1074/jbc.M408802200
1719:Nucleic Acids Research
1550:10.1074/jbc.M408802200
1083:10.1074/jbc.M408802200
1029:10.1006/geno.2002.6718
530:innate immune response
45:Human UniProt search:
2893:Eadie–Hofstee diagram
2826:Allosteric regulation
1859:10.1515/hsz-2013-0165
1257:10.1099/vir.0.83507-0
515:immune system process
181:Chromosome 22 (human)
2903:Lineweaver–Burk plot
2655:GTP cyclohydrolase I
2384:genome location and
1847:Biological Chemistry
1682:10.1128/JVI.01497-16
1207:10.1128/JVI.00290-11
525:cytidine deamination
345:smooth muscle tissue
325:right adrenal cortex
145:APOBEC3C - orthologs
62:List of PDB id codes
35:Available structures
2635:Adenosine deaminase
2534:Histone deacetylase
2392:UCSC Genome Browser
2183:Journal of Virology
1957:1999Natur.402..489D
1801:Journal of Virology
1676:(22): 10193–10208.
1670:Journal of Virology
1195:Journal of Virology
333:left adrenal cortex
2862:Enzyme superfamily
2795:Enzyme promiscuity
2660:Cytidine deaminase
2619:: Cyclic amidines/
2586:: Linear amidines/
2346:10.1093/nar/gkm181
2303:10.1038/msb4100134
2115:10.1093/nar/gki343
1768:Trends in Genetics
1731:10.1093/nar/gkt898
1461:10.1038/ni0703-641
923:cytidine deaminase
503:Biological process
477:Cellular component
453:hydrolase activity
443:catalytic activity
426:Molecular function
329:left adrenal gland
3018:
3017:
2727:
2726:
2630:Guanine deaminase
2465:: Linear amides /
1635:10.1038/nsmb.2378
1585:(23): 6200–6227.
1449:Nature Immunology
1293:10.1093/jb/mvr086
1250:(Pt 5): 1184–91.
1159:10.1002/hep.21733
889:
888:
885:
884:
861:
860:
825:
824:
806:
805:
780:
779:
761:
760:
735:
734:
718:
717:
692:
691:
675:
674:
649:
648:
632:
631:
580:
579:
545:DNA demethylation
458:metal ion binding
410:
409:
406:
405:
384:
383:
371:
370:
352:
351:
250:
249:
85:
84:
81:
80:
3065:
3035:
3034:
3026:
2898:Hanes–Woolf plot
2841:Enzyme activator
2836:Enzyme inhibitor
2810:Enzyme catalysis
2754:
2747:
2740:
2731:
2553:: Cyclic amides/
2443:
2436:
2429:
2420:
2367:
2357:
2324:
2314:
2280:
2270:
2261:(31): 22161–72.
2245:
2216:
2206:
2173:
2136:
2126:
2093:
2083:
2074:(51): 53379–86.
2058:
2048:
2038:
2013:
2003:
1978:
1968:
1951:(6761): 489–95.
1934:
1924:
1899:
1878:
1844:
1834:
1824:
1791:
1753:
1752:
1742:
1710:
1704:
1703:
1693:
1661:
1655:
1654:
1617:
1611:
1610:
1569:
1563:
1562:
1552:
1543:(51): 53379–86.
1528:
1522:
1521:
1511:
1487:
1481:
1480:
1444:
1438:
1437:
1427:
1403:
1397:
1396:
1360:
1354:
1353:
1343:
1311:
1305:
1304:
1276:
1270:
1269:
1259:
1235:
1229:
1228:
1218:
1201:(15): 7594–602.
1186:
1180:
1179:
1161:
1137:
1131:
1130:
1113:(8): 1171–1191.
1102:
1096:
1095:
1085:
1076:(51): 53379–86.
1061:
1055:
1054:
1047:
1041:
1040:
1012:
1006:
1005:
994:
988:
978:
938:gene duplication
874:
873:
857:
842:
837:
820:
810:
801:
789:
785:RefSeq (protein)
775:
765:
756:
744:
722:
703:
679:
660:
636:
617:
586:
448:zinc ion binding
416:
395:
380:
356:
309:white blood cell
301:
299:Top expressed in
294:
273:
256:
246:
233:
222:
207:
200:
194:
183:
169:
153:
147:
106:
99:
76:
59:
53:
32:
31:
19:
3073:
3072:
3068:
3067:
3066:
3064:
3063:
3062:
3043:
3042:
3041:
3029:
3021:
3019:
3014:
2926:Oxidoreductases
2912:
2888:Enzyme kinetics
2876:
2872:List of enzymes
2845:
2814:
2785:Catalytic triad
2763:
2758:
2728:
2723:
2699:
2687:Aminohydrolases
2685:
2676:
2622:Aminohydrolases
2620:
2611:
2587:
2578:
2556:Amidohydrolases
2554:
2545:
2468:Amidohydrolases
2466:
2457:
2447:
2375:
2370:
2327:
2283:
2248:
2219:
2176:
2139:
2096:
2061:
2016:
1981:
1937:
1902:
1881:
1853:(11): 1357–70.
1842:
1837:
1794:
1765:
1761:
1759:Further reading
1756:
1712:
1711:
1707:
1663:
1662:
1658:
1629:(10): 1005–10.
1619:
1618:
1614:
1571:
1570:
1566:
1530:
1529:
1525:
1489:
1488:
1484:
1446:
1445:
1441:
1405:
1404:
1400:
1377:10.1038/nsmb758
1362:
1361:
1357:
1313:
1312:
1308:
1278:
1277:
1273:
1237:
1236:
1232:
1188:
1187:
1183:
1139:
1138:
1134:
1104:
1103:
1099:
1063:
1062:
1058:
1049:
1048:
1044:
1014:
1013:
1009:
996:
995:
991:
979:
970:
966:
954:
919:
878:View/Edit Human
855:
840:
833:
830:Location (UCSC)
818:
797:
773:
752:
669:ENSG00000244509
564:
498:
472:
433:protein binding
376:
367:
348:
343:
339:
335:
331:
327:
323:
319:
315:
311:
297:
241:
228:
220:
210:
209:
208:
201:
179:
156:Gene location (
115:
102:
95:
68:
46:
17:
12:
11:
5:
3071:
3069:
3061:
3060:
3055:
3045:
3044:
3040:
3039:
3016:
3015:
3013:
3012:
2999:
2986:
2973:
2960:
2947:
2934:
2920:
2918:
2914:
2913:
2911:
2910:
2905:
2900:
2895:
2890:
2884:
2882:
2878:
2877:
2875:
2874:
2869:
2864:
2859:
2853:
2851:
2850:Classification
2847:
2846:
2844:
2843:
2838:
2833:
2828:
2822:
2820:
2816:
2815:
2813:
2812:
2807:
2802:
2797:
2792:
2787:
2782:
2777:
2771:
2769:
2765:
2764:
2759:
2757:
2756:
2749:
2742:
2734:
2725:
2724:
2722:
2721:
2716:
2710:
2708:
2701:
2700:
2698:
2697:
2691:
2689:
2678:
2677:
2675:
2674:
2673:
2672:
2667:
2657:
2652:
2650:DCMP deaminase
2647:
2642:
2637:
2632:
2626:
2624:
2613:
2612:
2610:
2609:
2604:
2599:
2593:
2591:
2589:Ureohydrolases
2580:
2579:
2577:
2576:
2574:Dihydroorotase
2571:
2569:Beta-lactamase
2566:
2560:
2558:
2547:
2546:
2544:
2543:
2542:
2541:
2531:
2526:
2521:
2516:
2515:
2514:
2509:
2506:Aspartoacylase
2503:
2493:
2488:
2483:
2478:
2472:
2470:
2459:
2458:
2448:
2446:
2445:
2438:
2431:
2423:
2417:
2416:
2395:
2374:
2373:External links
2371:
2369:
2368:
2340:(9): 2955–64.
2325:
2281:
2246:
2217:
2189:(13): 8201–7.
2174:
2148:(1–3): 203–8.
2137:
2109:(6): 1913–23.
2094:
2059:
2023:Genome Biology
2014:
1979:
1966:10.1038/990031
1935:
1900:
1879:
1835:
1807:(3): 1067–76.
1792:
1762:
1760:
1757:
1755:
1754:
1725:(1): 396–416.
1705:
1656:
1612:
1564:
1523:
1482:
1439:
1418:(5): 1247–53.
1412:Molecular Cell
1398:
1355:
1306:
1271:
1230:
1181:
1132:
1097:
1056:
1042:
1007:
989:
967:
965:
962:
953:
950:
918:
915:
887:
886:
883:
882:
880:
870:
869:
863:
862:
859:
858:
853:
851:
844:
843:
838:
831:
827:
826:
823:
822:
814:
813:
807:
804:
803:
793:
792:
786:
782:
781:
778:
777:
769:
768:
762:
759:
758:
748:
747:
741:
737:
736:
733:
732:
726:
725:
719:
716:
715:
707:
706:
700:
694:
693:
690:
689:
683:
682:
676:
673:
672:
664:
663:
657:
651:
650:
647:
646:
640:
639:
633:
630:
629:
621:
620:
614:
608:
607:
602:
597:
593:
592:
582:
581:
578:
577:
566:
565:
563:
562:
557:
552:
547:
542:
537:
532:
527:
522:
517:
512:
506:
504:
500:
499:
497:
496:
491:
486:
480:
478:
474:
473:
471:
470:
465:
460:
455:
450:
445:
440:
435:
429:
427:
423:
422:
412:
411:
408:
407:
404:
403:
400:
399:
392:
386:
385:
382:
381:
373:
372:
369:
368:
366:
363:
360:
359:
353:
350:
349:
347:
346:
342:
338:
334:
330:
326:
322:
318:
314:
310:
306:
303:
302:
290:
289:
281:
270:
264:
263:
260:RNA expression
252:
251:
248:
247:
239:
235:
234:
226:
223:
218:
212:
211:
202:
195:
189:
185:
184:
177:
171:
170:
162:
161:
149:
148:
113:
109:
108:
100:
92:
91:
87:
86:
83:
82:
79:
78:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
3070:
3059:
3056:
3054:
3051:
3050:
3048:
3038:
3033:
3028:
3024:
3010:
3006:
3005:
3000:
2997:
2993:
2992:
2987:
2984:
2980:
2979:
2974:
2971:
2967:
2966:
2961:
2958:
2954:
2953:
2948:
2945:
2941:
2940:
2935:
2932:
2928:
2927:
2922:
2921:
2919:
2915:
2909:
2906:
2904:
2901:
2899:
2896:
2894:
2891:
2889:
2886:
2885:
2883:
2879:
2873:
2870:
2868:
2867:Enzyme family
2865:
2863:
2860:
2858:
2855:
2854:
2852:
2848:
2842:
2839:
2837:
2834:
2832:
2831:Cooperativity
2829:
2827:
2824:
2823:
2821:
2817:
2811:
2808:
2806:
2803:
2801:
2798:
2796:
2793:
2791:
2790:Oxyanion hole
2788:
2786:
2783:
2781:
2778:
2776:
2773:
2772:
2770:
2766:
2762:
2755:
2750:
2748:
2743:
2741:
2736:
2735:
2732:
2720:
2719:Thiaminase II
2717:
2715:
2714:Riboflavinase
2712:
2711:
2709:
2706:
2702:
2696:
2693:
2692:
2690:
2688:
2683:
2679:
2671:
2668:
2666:
2663:
2662:
2661:
2658:
2656:
2653:
2651:
2648:
2646:
2643:
2641:
2640:AMP deaminase
2638:
2636:
2633:
2631:
2628:
2627:
2625:
2623:
2618:
2614:
2608:
2605:
2603:
2600:
2598:
2595:
2594:
2592:
2590:
2585:
2581:
2575:
2572:
2570:
2567:
2565:
2562:
2561:
2559:
2557:
2552:
2548:
2540:
2537:
2536:
2535:
2532:
2530:
2527:
2525:
2522:
2520:
2517:
2513:
2510:
2507:
2504:
2502:
2499:
2498:
2497:
2494:
2492:
2489:
2487:
2484:
2482:
2479:
2477:
2474:
2473:
2471:
2469:
2464:
2460:
2455:
2451:
2444:
2439:
2437:
2432:
2430:
2425:
2424:
2421:
2414:
2410:
2409:
2404:
2400:
2396:
2393:
2389:
2388:
2383:
2382:
2377:
2376:
2372:
2365:
2361:
2356:
2351:
2347:
2343:
2339:
2335:
2331:
2326:
2322:
2318:
2313:
2308:
2304:
2300:
2296:
2292:
2288:
2282:
2278:
2274:
2269:
2264:
2260:
2256:
2252:
2247:
2243:
2239:
2235:
2231:
2227:
2223:
2218:
2214:
2210:
2205:
2200:
2196:
2192:
2188:
2184:
2180:
2175:
2171:
2167:
2163:
2159:
2155:
2151:
2147:
2143:
2138:
2134:
2130:
2125:
2120:
2116:
2112:
2108:
2104:
2100:
2095:
2091:
2087:
2082:
2077:
2073:
2069:
2065:
2060:
2056:
2052:
2047:
2042:
2037:
2032:
2028:
2024:
2020:
2015:
2011:
2007:
2002:
1997:
1993:
1989:
1985:
1980:
1976:
1972:
1967:
1962:
1958:
1954:
1950:
1946:
1942:
1936:
1932:
1928:
1923:
1918:
1914:
1910:
1906:
1901:
1897:
1893:
1890:(3): 148–57.
1889:
1885:
1880:
1876:
1872:
1868:
1864:
1860:
1856:
1852:
1848:
1841:
1836:
1832:
1828:
1823:
1818:
1814:
1810:
1806:
1802:
1798:
1793:
1789:
1785:
1781:
1777:
1774:(4): 207–16.
1773:
1769:
1764:
1763:
1758:
1750:
1746:
1741:
1736:
1732:
1728:
1724:
1720:
1716:
1709:
1706:
1701:
1697:
1692:
1687:
1683:
1679:
1675:
1671:
1667:
1660:
1657:
1652:
1648:
1644:
1640:
1636:
1632:
1628:
1624:
1616:
1613:
1608:
1604:
1600:
1596:
1592:
1588:
1584:
1580:
1576:
1568:
1565:
1560:
1556:
1551:
1546:
1542:
1538:
1534:
1527:
1524:
1519:
1515:
1510:
1505:
1501:
1497:
1493:
1486:
1483:
1478:
1474:
1470:
1466:
1462:
1458:
1454:
1450:
1443:
1440:
1435:
1431:
1426:
1421:
1417:
1413:
1409:
1402:
1399:
1394:
1390:
1386:
1382:
1378:
1374:
1371:(5): 435–42.
1370:
1366:
1359:
1356:
1351:
1347:
1342:
1337:
1333:
1329:
1325:
1321:
1317:
1310:
1307:
1302:
1298:
1294:
1290:
1286:
1282:
1275:
1272:
1267:
1263:
1258:
1253:
1249:
1245:
1241:
1234:
1231:
1226:
1222:
1217:
1212:
1208:
1204:
1200:
1196:
1192:
1185:
1182:
1177:
1173:
1169:
1165:
1160:
1155:
1151:
1147:
1143:
1136:
1133:
1128:
1124:
1120:
1116:
1112:
1108:
1101:
1098:
1093:
1089:
1084:
1079:
1075:
1071:
1067:
1060:
1057:
1052:
1046:
1043:
1038:
1034:
1030:
1026:
1023:(3): 285–96.
1022:
1018:
1011:
1008:
1003:
999:
993:
990:
986:
982:
977:
975:
973:
969:
963:
961:
959:
951:
949:
947:
943:
942:chromosome 22
939:
935:
931:
927:
924:
916:
914:
912:
906:
904:
901:
897:
893:
879:
875:
871:
868:
864:
854:
852:
849:
845:
839:
836:
832:
828:
821:
815:
811:
808:
802:
800:
794:
790:
787:
783:
776:
770:
766:
763:
757:
755:
749:
745:
742:
740:RefSeq (mRNA)
738:
731:
727:
723:
720:
714:
713:
708:
704:
701:
699:
695:
688:
684:
680:
677:
671:
670:
665:
661:
658:
656:
652:
645:
641:
637:
634:
628:
627:
622:
618:
615:
613:
609:
606:
603:
601:
598:
594:
591:
587:
583:
576:
572:
567:
561:
558:
556:
553:
551:
548:
546:
543:
541:
538:
536:
535:viral process
533:
531:
528:
526:
523:
521:
518:
516:
513:
511:
508:
507:
505:
502:
501:
495:
492:
490:
487:
485:
482:
481:
479:
476:
475:
469:
466:
464:
461:
459:
456:
454:
451:
449:
446:
444:
441:
439:
436:
434:
431:
430:
428:
425:
424:
421:
420:Gene ontology
417:
413:
401:
396:
393:
391:
387:
379:
374:
364:
361:
357:
354:
344:
340:
336:
332:
328:
324:
320:
316:
312:
308:
307:
304:
300:
295:
292:
291:
288:
286:
282:
280:
279:
275:
274:
271:
269:
265:
261:
257:
253:
245:
240:
236:
232:
227:
217:
213:
206:
199:
193:
186:
182:
176:
172:
168:
163:
159:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
110:
105:
98:
93:
88:
77:
75:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
3004:Translocases
3001:
2988:
2975:
2962:
2949:
2939:Transferases
2936:
2923:
2780:Binding site
2496:Aminoacylase
2476:Asparaginase
2406:
2386:
2380:
2337:
2333:
2294:
2290:
2258:
2254:
2228:(7): 611–9.
2225:
2221:
2186:
2182:
2145:
2141:
2106:
2102:
2071:
2067:
2026:
2022:
1994:(1): 21–31.
1991:
1987:
1948:
1944:
1915:(2): 162–9.
1912:
1908:
1887:
1884:AIDS Reviews
1883:
1850:
1846:
1804:
1800:
1771:
1767:
1722:
1718:
1708:
1673:
1669:
1659:
1626:
1622:
1615:
1582:
1578:
1567:
1540:
1536:
1526:
1502:(6): 803–9.
1499:
1495:
1485:
1455:(7): 641–3.
1452:
1448:
1442:
1415:
1411:
1401:
1368:
1364:
1358:
1326:(3): 295–9.
1323:
1319:
1309:
1287:(4): 371–4.
1284:
1280:
1274:
1247:
1243:
1233:
1198:
1194:
1184:
1152:(3): 682–9.
1149:
1145:
1135:
1110:
1106:
1100:
1073:
1069:
1059:
1045:
1020:
1016:
1010:
1001:
992:
955:
920:
907:
899:
891:
890:
817:
796:
772:
751:
729:
710:
686:
667:
643:
624:
604:
599:
283:
276:
112:External IDs
67:
2775:Active site
2684:: Nitriles/
2564:Barbiturase
2491:Biotinidase
2481:Glutaminase
2029:(10): R84.
932:found in a
930:pseudogenes
926:gene family
463:RNA binding
313:granulocyte
242:39,020,352
229:39,014,257
90:Identifiers
3047:Categories
2978:Isomerases
2952:Hydrolases
2819:Regulation
2602:Agmatinase
2519:Ceramidase
2450:Hydrolases
1341:2297/44628
1146:Hepatology
987:, May 2017
964:References
321:lymph node
287:(ortholog)
125:HomoloGene
2857:EC number
2695:Nitrilase
2297:(1): 89.
1607:224318971
952:Structure
799:NP_055323
754:NM_014508
590:Orthologs
489:cytoplasm
133:GeneCards
3058:EC 3.5.4
2881:Kinetics
2805:Cofactor
2768:Activity
2597:Arginase
2387:APOBEC3C
2381:APOBEC3C
2364:17439959
2321:17353931
2277:16735504
2242:16060832
2213:15956565
2162:15862967
2133:15809227
2090:15466872
2055:15461802
2010:12859895
1975:10591208
1931:10469298
1896:17078485
1867:23787464
1831:16414984
1788:12683974
1749:24101588
1700:27581978
1643:23001005
1599:33068636
1559:15466872
1518:12809610
1469:12830140
1434:12453430
1393:24306371
1385:15098018
1350:25576866
1301:21746770
1266:18420796
1225:21632763
1168:17625792
1127:28315663
1092:15466872
1037:11863358
1017:Genomics
983:–
917:Function
900:APOBEC3C
867:Wikidata
569:Sources:
317:monocyte
137:APOBEC3C
104:APOBEC3C
22:APOBEC3C
3037:Biology
2991:Ligases
2761:Enzymes
2707:: Other
2539:Sirtuin
2413:PDBe-KB
2403:UniProt
2355:1888823
2312:1847948
2204:1143768
2170:9746088
2124:1074398
1953:Bibcode
1875:4151961
1822:1346961
1740:3874205
1691:5105656
1651:7871310
1477:5549252
1216:3147940
1176:9029300
985:Ensembl
946:APOBEC1
934:cluster
896:protein
698:UniProt
655:Ensembl
596:Species
575:QuickGO
484:nucleus
262:pattern
221:22q13.1
97:Aliases
3023:Portal
2965:Lyases
2705:3.5.99
2508:(ACY2)
2486:Urease
2408:Q9NRW3
2378:Human
2362:
2352:
2319:
2309:
2275:
2240:
2211:
2201:
2168:
2160:
2131:
2121:
2088:
2053:
2046:545604
2043:
2008:
1973:
1945:Nature
1929:
1894:
1873:
1865:
1829:
1819:
1786:
1747:
1737:
1698:
1688:
1649:
1641:
1605:
1597:
1557:
1516:
1475:
1467:
1432:
1391:
1383:
1348:
1299:
1264:
1223:
1213:
1174:
1166:
1125:
1090:
1035:
958:LINE-1
850:search
848:PubMed
712:Q9NRW3
612:Entrez
494:P-body
390:BioGPS
337:rectum
129:129856
121:607750
2917:Types
2682:3.5.5
2665:AICDA
2617:3.5.4
2584:3.5.3
2551:3.5.2
2463:3.5.1
2166:S2CID
1871:S2CID
1843:(PDF)
1647:S2CID
1603:S2CID
1473:S2CID
1389:S2CID
1172:S2CID
940:, on
894:is a
626:27350
605:Mouse
600:Human
571:Amigo
285:Mouse
278:Human
225:Start
158:Human
3009:list
3002:EC7
2996:list
2989:EC6
2983:list
2976:EC5
2970:list
2963:EC4
2957:list
2950:EC3
2944:list
2937:EC2
2931:list
2924:EC1
2512:ACY3
2501:ACY1
2456:3.5)
2401:for
2360:PMID
2317:PMID
2273:PMID
2238:PMID
2209:PMID
2158:PMID
2129:PMID
2086:PMID
2051:PMID
2006:PMID
1988:Cell
1971:PMID
1927:PMID
1892:PMID
1863:PMID
1827:PMID
1784:PMID
1745:PMID
1696:PMID
1639:PMID
1595:PMID
1555:PMID
1514:PMID
1496:Cell
1465:PMID
1430:PMID
1381:PMID
1346:PMID
1297:PMID
1262:PMID
1221:PMID
1164:PMID
1123:PMID
1088:PMID
1033:PMID
903:gene
268:Bgee
216:Band
175:Chr.
117:OMIM
74:3VOW
70:3VM8
51:RCSB
48:PDBe
2399:PDB
2350:PMC
2342:doi
2307:PMC
2299:doi
2263:doi
2259:281
2230:doi
2199:PMC
2191:doi
2150:doi
2119:PMC
2111:doi
2076:doi
2072:279
2041:PMC
2031:doi
1996:doi
1992:114
1961:doi
1949:402
1917:doi
1913:113
1855:doi
1851:394
1817:PMC
1809:doi
1776:doi
1735:PMC
1727:doi
1686:PMC
1678:doi
1631:doi
1587:doi
1583:432
1545:doi
1541:279
1504:doi
1500:113
1457:doi
1420:doi
1373:doi
1336:hdl
1328:doi
1324:457
1289:doi
1285:150
1252:doi
1211:PMC
1203:doi
1154:doi
1115:doi
1111:429
1078:doi
1074:279
1025:doi
911:Vif
856:n/a
841:n/a
819:n/a
774:n/a
730:n/a
687:n/a
644:n/a
398:n/a
365:n/a
238:End
141:OMA
41:PDB
3049::
2454:EC
2405::
2358:.
2348:.
2338:35
2336:.
2332:.
2315:.
2305:.
2293:.
2289:.
2271:.
2257:.
2253:.
2236:.
2226:21
2224:.
2207:.
2197:.
2187:79
2185:.
2181:.
2164:.
2156:.
2146:94
2144:.
2127:.
2117:.
2107:33
2105:.
2101:.
2084:.
2070:.
2066:.
2049:.
2039:.
2025:.
2021:.
2004:.
1990:.
1986:.
1969:.
1959:.
1947:.
1943:.
1925:.
1911:.
1907:.
1886:.
1869:.
1861:.
1849:.
1845:.
1825:.
1815:.
1805:80
1803:.
1799:.
1782:.
1772:19
1770:.
1743:.
1733:.
1723:42
1721:.
1717:.
1694:.
1684:.
1674:90
1672:.
1668:.
1645:.
1637:.
1627:19
1625:.
1601:.
1593:.
1581:.
1577:.
1553:.
1539:.
1535:.
1512:.
1498:.
1494:.
1471:.
1463:.
1451:.
1428:.
1416:10
1414:.
1410:.
1387:.
1379:.
1369:11
1367:.
1344:.
1334:.
1322:.
1318:.
1295:.
1283:.
1260:.
1248:89
1246:.
1242:.
1219:.
1209:.
1199:85
1197:.
1193:.
1170:.
1162:.
1150:46
1148:.
1144:.
1121:.
1109:.
1086:.
1072:.
1068:.
1031:.
1021:79
1019:.
1000:.
971:^
905:.
573:/
244:bp
231:bp
139:;
135::
131:;
127::
123:;
119::
72:,
3025::
3011:)
3007:(
2998:)
2994:(
2985:)
2981:(
2972:)
2968:(
2959:)
2955:(
2946:)
2942:(
2933:)
2929:(
2753:e
2746:t
2739:v
2442:e
2435:t
2428:v
2415:.
2394:.
2366:.
2344::
2323:.
2301::
2295:3
2279:.
2265::
2244:.
2232::
2215:.
2193::
2172:.
2152::
2135:.
2113::
2092:.
2078::
2057:.
2033::
2027:5
2012:.
1998::
1977:.
1963::
1955::
1933:.
1919::
1898:.
1888:8
1877:.
1857::
1833:.
1811::
1790:.
1778::
1751:.
1729::
1702:.
1680::
1653:.
1633::
1609:.
1589::
1561:.
1547::
1520:.
1506::
1479:.
1459::
1453:4
1436:.
1422::
1395:.
1375::
1352:.
1338::
1330::
1303:.
1291::
1268:.
1254::
1227:.
1205::
1178:.
1156::
1129:.
1117::
1094:.
1080::
1053:.
1039:.
1027::
1004:.
160:)
143::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
