568:, it is still a very simple virus and is heavily reliant on the host cell for survival and replication. The genes of adenoviruses can generally be divided into well-conserved sets of transcription units with six early transcription units (E1A, E1B, E2A, E2B, E3 and E4) and one late transcription unit ranging from L1-L5. In addition, adenoviruses also contain two intermediate transcription units named XI and IVa2. To increase the viral gene economy, adenoviruses accommodate genes on both strands of its dsDNA meaning that most of its genome is utilized for coding proteins. An interesting feature of this viral genome is that it has a terminal 55
653:) is released from it. Protein VI contains an N-terminal amphiphatic alpha-helix, a helical domain that exhibits both hydrophobic and hydrophilic properties. This amphipathic helix enables the binding of protein VI to the endsomal membrane leading to a severe membrane curvature that ultimately disrupts the endosome. These changes, as well as the toxic nature of the pentons, destroy the endosome, resulting in the movement of the virion into the cytoplasm. With the help of cellular
240:
92:
549:
485:
1324:
1416:
71:
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1527:
1513:
9235:
1615:
780:
irradiated with UV light and allowed to undergo multiple infection of host cells. In a review, numerous examples of MR in different viruses were described, and it was suggested that MR is a common form of sexual interaction that provides the survival advantage of recombinational repair of genome damages.
1046:
Diagnosis is from symptoms and history. Tests are only necessary in very serious cases. Tests include blood tests, eyes, nose or throat swabs, stool sample tests, and chest x-rays. In the laboratory, adenovirus can be identified with antigen detection, polymerase chain reaction (PCR), virus isolation
1127:
Adenoviruses are often transmitted by expectoration (e.g. aerosols), but they can also be transmitted by contact with an infected person, or by virus particles left on objects such as towels and faucet handles. Some people with adenovirus gastroenteritis may shed the virus in their stools for months
754:
DNA replication separates the early and late phases. Once the early genes have liberated adequate virus proteins, replication machinery, and replication substrates, replication of the adenovirus genome can occur. A terminal protein that is covalently bound to the 5' end of the adenovirus genome acts
1033:
In the past, US military recruits were vaccinated against two serotypes of adenovirus, with a corresponding decrease in illnesses caused by those serotypes. That vaccine is no longer manufactured. The U.S. Army
Medical Research and Materiel Command announced on 31 October 2011 that a new adenovirus
1029:
Currently there is a vaccine for adenovirus type 4 and 7 for US military personnel only. US military personnel are the recipients of this vaccine because they may be at a higher risk of infection. The vaccine contains a live virus, which may be shed in stool and lead to transmission. The vaccine is
1123:
sometimes die of adenovirus infections, and—rarely—even previously healthy people can die of these infections. This may be because sometimes adenoviral infection can lead to cardiac disorders. For example, in one study, some cardiac samples of patients with dilated cardiomyopathy were positive for
1037:
Prevention of adenovirus, as well as other respiratory illnesses, involves frequent hand washing for more than 20 seconds, avoiding touching the eyes, face, and nose with unwashed hands, and avoiding close contact with people with symptomatic adenovirus infection. Those with symptomatic adenovirus
766:
The late phase of the adenovirus lifecycle is focused on producing sufficient quantities of structural protein to pack all the genetic material produced by DNA replication. Once the viral components have successfully been replicated, the virus is assembled into its protein shells and released from
1151:
has helped certain of those patients who had severe cases of illness; the number helped and to what degree, and the particular complications or symptoms it helped with, and when and where this happened, were not given in the source. A doctor may give antibiotic eyedrops for conjunctivitis, while
779:
Adenovirus is capable of multiplicity reactivation (MR) (Yamamoto and
Shimojo, 1971). MR is the process by which two, or more, virus genomes containing lethal damage interact within the infected cell to form a viable virus genome. Such MR was demonstrated for adenovirus 12 after virions were
1309:
Possible issues with using
Adenovirus as vaccine vectors include: the human body develops immunity to the vector itself, making subsequent booster shots difficult or impossible. In some cases, people have pre-existing immunity to Adenoviruses, making vector delivery ineffective.
1038:
infection are additionally advised to cough or sneeze into the arm or elbow instead of the hand, to avoid sharing cups and eating utensils, and to refrain from kissing others. Chlorination of swimming pools can prevent outbreaks of conjunctivitis caused by adenovirus.
1436:: "On the basis of these findings, we are concerned that use of an Ad5 vector for immunisation against SARS-CoV-2 could similarly increase the risk of HIV-1 acquisition among men who receive the vaccine." Vaccines using other technologies would not be affected, but
669:
molecules already present in the nucleus, which allows it to interact with the host cell transcription machinery. Then, viral gene expression can occur, without integrating the viral genome into host cell chromosomes, and new virus particles can be generated.
1500:
could have contributed to masking a possible causal link in the Ebola vaccine trial; while the Step trial enrolled mainly homosexual and bisexual men, the
Phambili trial enrolled mainly heterosexual men and women and still found an apparent connection.
1488:, making it more likely for such problems to be detected. CanSino's CEO said "we haven't seen anything with the Ebola vaccine" and speculated that HIV susceptibility might be limited to Ad5 vaccines which produced HIV proteins. In research reported in
596:
cells using the host's replication machinery. Entry of adenoviruses into the host cell involves two sets of interactions between the virus and the host cell. Most of the action occurs at the vertices. Entry into the host cell is initiated by the knob
648:
Once the virus has successfully gained entry into the host cell, the endosome acidifies, which alters virus topology by causing capsid components to disband. The capsid is destabilized and protein VI, which is one of the capsid constituents (see
1152:
awaiting results of bacterial cultures, and to help prevent secondary bacterial infections. Currently, there is no adenovirus vaccine available to the general public, but a vaccine is available for the United States military for Types 4 and 7.
3238:
Hosseini SM, Mirhosseini SM, Taghian M, Salehi M, Farahani MM, Bakhtiari F, et al. (October 2018). "First evidence of the presence of adenovirus type 8 in myocardium of patients with severe idiopathic dilated cardiomyopathy".
3383:
Xin KQ, Sekimoto Y, Takahashi T, Mizuguchi H, Ichino M, Yoshida A, et al. (May 2007). "Chimeric adenovirus 5/35 vector containing the clade C HIV gag gene induces a cross-reactive immune response against HIV".
1425:
The use of Ad5 vaccines for COVID-19 worried researchers who had experience with two failed trials of an Ad5 vaccine, Phambili and STEP, due to the increased risk for uncircumcised male patients of contracting
2977:
921:
Squirrel adenovirus (SqAdV) is reported to cause enteritis in red squirrels in Europe, while gray squirrels seem to be resistant. SqAdV is most closely related to the adenovirus of guinea pigs (GpAdV).
572:
protein associated with each of the 5' ends of the linear dsDNA. These are used as primers in viral replication and ensure that the ends of the virus' linear genome are adequately replicated.
4408:
1430:
via unprotected anal sex. At the time, it was concluded that heightened risk of HIV reception may be observed for any Ad5-based vector vaccine. In
October 2020, these researchers wrote in
8810:
3419:
Naskalska A, Szolajska E, Chaperot L, Angel J, Plumas J, Chroboczek J (December 2009). "Influenza recombinant vaccine: matrix protein M1 on the platform of the adenovirus dodecahedron".
1047:
and serology. Even if adenovirus is found to be present, it may not be the cause of any symptoms. Some immunocompromised individuals can shed the virus for weeks and show no symptoms.
3777:"Safety and immunogenicity of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine in two formulations: two open, non-randomised phase 1/2 studies from Russia"
3653:"Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial"
526:
In 2010, the structure of the human adenovirus was solved at the atomic level, making it the largest high-resolution model ever. The virus is composed of around 1 million
801:
conditions, allowing for prolonged survival outside of the body and water. Adenoviruses are spread primarily via respiratory droplets, however they can also be spread by
8233:
1334:
1270:. "In four candidate COVID-19 vaccines... Ad5... serves as the 'vector' to transport the surface protein gene of SARS-CoV-2". The goal is to genetically express the
9359:
3303:"A genetically engineered adenovirus vector targeted to CD40 mediates transduction of canine dendritic cells and promotes antigen-specific immune responses in vivo"
3118:
1648:, Gilmore LK, Parrott RH, Ward TG (December 1953). "Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture".
1275:
4401:
467:
9372:
8824:
657:, the virus is transported to the nuclear pore complex, whereby the adenovirus particle disassembles. Viral DNA is subsequently released, which can enter the
3548:"Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial"
747:
tumor suppressor) to assist and stably transform the cells. Nevertheless, they are reliant upon each other to successfully transform the host cell and form
512:
make up the bulk of the capsid, while twelve penton bases cap the icosahedron's corners. The penton bases are associated with protruding fibers that aid in
8490:
8321:
1030:
not approved for use outside of the military, as it has not been tested in studied in the general population or on people with weakened immune systems.
8361:
4394:
1194:
3595:
1034:
vaccine, which replaces the older version that has been out of production for over a decade, was shipped to basic training sites on 18 October 2011.
9346:
1177:, and code for proteins without integrating genetic material into the host cell genome. More specifically, they are used as a vehicle to administer
1279:
3524:
2646:
Yamamoto H, Shimojo H (August 1971). "Multiplicity reactivation of human adenovirus type 12 and simian virus 40 irradiated by ultraviolet light".
1298:(aka Sputnik-V) product is innovative because an Ad26 based vaccine is used on the first day and an Ad5 vaccine is used on day 21. Another one is
8226:
4193:
3465:
3367:
2920:
2375:
2307:
2152:
1220:
A safety issue with adenoviruses is that they can cause an immune response with a related inflammatory response as occurred in the death of
8454:
1131:
As with many other illnesses, good handwashing practice is one way to inhibit the person-to-person transmission of adenoviruses. Heat and
809:). Research into the molecular mechanisms underlying adenoviral transmission provide empirical evidence in support of the hypothesis that
617:
residues functioning in this capacity as well. This is followed by a secondary interaction, where a motif in the penton base protein (see
4046:"Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals"
1224:
in 1999. To address this risk, the genome of the viral genes have been modified to remove some viral genes. One such modification is the
8511:
3958:
2545:"Adenovirus-Mediated Gene Delivery: Potential Applications for Gene and Cell-Based Therapies in the New Era of Personalized Medicine"
1213:
and prevent multiple organ failure. Adenovirus dodecahedron can qualify as a potent delivery platform for foreign antigens to human
8830:
8356:
8313:
8745:
911:
include attenuated live CAdV-2, which produces immunity to CAdV-1 and CAdV-2. CAdV-1 was initially used in a vaccine for dogs, but
1492:
in May, the company's researchers acknowledged the possibility, called it "controversial" and said they would watch for it in the
9395:
8816:
8219:
3283:
827:
Humans infected with adenoviruses display a wide range of responses, from no symptoms at all to the severe infections typical of
610:
78:
1128:
after getting over the symptoms. The virus can be passed through water in swimming pools that are not sufficiently chlorinated.
3038:"Cross-species transmission of a novel adenovirus associated with a fulminant pneumonia outbreak in a new world monkey colony"
1143:
There are no proven antiviral drugs to treat adenoviral infections, so treatment is largely directed at the symptoms (such as
8415:
8401:
1198:
1061:
Most infections with adenovirus result in infections of the upper respiratory tract. Adenovirus infections often present as
641:
polymerization, which facilitates clathrin-mediated endocytosis, and results in virion's entry into the host cell within an
1395:
751:. E1A is mostly intrinsically disordered protein and contains CR3 domain which is critical for transcriptional activation.
3122:
1823:"Computational analysis and identification of an emergent human adenovirus pathogen implicated in a respiratory fatality"
1367:
8620:
8614:
8525:
8519:
8409:
1445:
412:, 37, 38, 39, 42, 43, 44, 45, 46, 47, 48, 49, 51, 53, 54, 56, 58, 59, 60, 62, 63, 64, 65, 67, 69, 70, 71, 72, 73, 74, 75
3775:
Logunov DY, Dolzhikova IV, Zubkova OV, Tukhvatulin AI, Shcheblyakov DV, Dzharullaeva AS, et al. (September 2020).
2775:"Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells"
91:
8983:
8909:
8903:
8576:
6194:
3490:
1497:
1271:
876:
3104:
1374:
1306:(hACE2) receptors, presumably receptors that allow virus-entry into the cells, from being infected with SARS-CoV-2.
759:
for replication. The viral DNA polymerase then uses a strand displacement mechanism, as opposed to the conventional
9225:
7938:
7443:
6517:
3623:"An Open Study of the Safety, Tolerability and Immunogenicity of the Drug "Gam-COVID-Vac" Vaccine Against COVID-19"
1921:"Recombination of the epsilon determinant and corneal tropism: Human adenovirus species D types 15, 29, 56, and 69"
756:
732:
9377:
1096:, both of which can be severe. In babies, adenoviruses can also cause coughing fits that look almost exactly like
625:
molecule. It is the co-receptor interaction that stimulates entry of the adenovirus. This co-receptor molecule is
9040:
8647:
4359:
4186:
1342:
8749:
8661:
8566:
8396:
8369:
8341:
8274:
4417:
1283:
565:
1381:
9428:
8545:
4316:
1970:"Pediatric acute gastroenteritis associated with adenovirus 40/41 in low-income and middle-income countries"
1353:
1338:
1113:
8739:
8335:
1286:
uses modified recombinant adenovirus type-26 (Ad26). Recombinant adenovirus type-5 (Ad5) are being used by
708:. The goal of these proteins is threefold: to alter the expression of host proteins that are necessary for
9263:
8939:
8917:
8796:
8792:
8788:
8784:
8677:
8571:
8532:
3036:
Chen EC, Yagi S, Kelly KR, Mendoza SP, Tarara RP, Canfield DR, et al. (July 2011). Nemerow GR (ed.).
828:
736:
698:
409:
393:
55:
3212:
1363:
379:
In humans, currently there are 88 human adenoviruses (HAdVs) in seven species (Human adenovirus A to G):
9423:
8924:
8505:
8375:
3491:"Adenoviral vectors are the new COVID-19 vaccine front-runners. Can they overcome their checkered past?"
806:
674:
430:
421:
415:
405:
399:
389:
383:
51:
47:
8346:
6705:
3700:
7179:
3728:"A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2"
9400:
9333:
9188:
9020:
8655:
8484:
7756:
7278:
6473:
4752:
4421:
4179:
4057:
3830:"Pre-existing immunity against Ad vectors: humoral, cellular, and innate response, what's important?"
3546:
Folegatti PM, Ewer KJ, Aley PK, Angus B, Becker S, Belij-Rammerstorfer S, et al. (August 2020).
2786:
2690:
2323:
Wu E, Nemerow GR (April 2004). "Virus yoga: the role of flexibility in virus host cell recognition".
2256:
2188:
1726:
1247:
1202:
1186:
1109:
1085:. A combination of conjunctivitis and tonsillitis is particularly common with adenovirus infections.
1056:
822:
686:
298:
86:
7575:
7243:
7186:
7158:
7130:
6800:
6484:
6415:
5675:
5668:
4759:
4717:
4710:
1821:
Robinson CM, Singh G, Henquell C, Walsh MP, Peigue-Lafeuille H, Seto D, et al. (January 2011).
1713:
Dhingra A, Hage E, Ganzenmueller T, Böttcher S, Hofmann J, Hamprecht K, et al. (January 2019).
731:
Some adenoviruses under specialized conditions can transform cells using their early gene products.
367:
228:
8606:
8327:
7770:
7624:
7403:
7151:
7144:
5964:
5162:
4780:
4766:
4724:
4637:
1256:) adenovirus vectors, including replication incompetent types, can deliver DNA coding for specific
556:
The adenovirus genome is linear, non-segmented double-stranded (ds) DNA that is between 26 and 48 k
501:
441:
425:
279:
7862:
7813:
7763:
7742:
7193:
4703:
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1455:
are more susceptible to HIV infection than CD4 T cells specific to certain other vectors, such as
8709:
8465:
7582:
6655:
6648:
5721:
5356:
5342:
4934:
4271:
4030:
3879:"HIV risk from some COVID-19 vaccines might be unlikely due to rarity of vector viruses involved"
3264:
2724:
Wang CC, Prather KA, Sznitman J, Jimenez JL, Lakdawala SS, Tufekci Z, et al. (August 2021).
2471:
2280:
2227:
2121:
1673:
1238:
systems, but high immune reactivity to viral infection has posed challenges in use for patients.
1024:
860:
845:
682:
8211:
601:
of the fiber protein binding to the cell receptor. The two currently established receptors are:
9301:
3301:
Thacker EE, Nakayama M, Smith BF, Bird RC, Muminova Z, Strong TV, et al. (November 2009).
2681:
Michod RE, Bernstein H, Nedelcu AM (May 2008). "Adaptive value of sex in microbial pathogens".
1774:"Computational analysis of two species C human adenoviruses provides evidence of a novel virus"
9320:
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2113:
2048:
1999:
1950:
1901:
1852:
1803:
1754:
1665:
1473:
1468:
925:
760:
716:); and to avoid premature death of the infected cell by the host-immune defenses (blockage of
650:
552:
Schematic diagram of the linear adenovirus genome, showing Early genes (E) and Late genes (L).
543:
140:
9387:
9364:
1173:
due to their ability to affect both replicating and non-replicating cells, accommodate large
887:. Type 1 infection can also cause respiratory and eye infections. CAdV-1 also affects foxes (
9148:
8858:
8538:
8470:
8351:
8282:
7668:
7596:
7489:
7064:
7006:
6969:
6698:
6429:
6387:
6335:
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6229:
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6009:
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4001:
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2502:
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2105:
2038:
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1989:
1981:
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1267:
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585:
569:
531:
306:
251:
152:
3726:
Hassan AO, Kafai NM, Dmitriev IP, Fox JM, Smith BK, Harvey IB, et al. (October 2020).
3701:"Experimental Nasal Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2"
2491:"Changes in adenoviral chromatin organization precede early gene activation upon infection"
2228:"Scientists unveil structure of adenovirus, the largest high-resolution complex ever found"
9239:
9072:
9000:
8995:
8977:
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6552:
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6104:
5825:
5332:
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5025:
4945:
4841:
2997:"Isolation and identification of a fowl adenovirus from wild Black Kites (Milvus migrans)"
2489:
Schwartz U, Komatsu T, Huber C, Lagadec F, Baumgartl C, Silberhorn E, et al. (2023).
2017:
Jones MS, Harrach B, Ganac RD, Gozum MM, Dela Cruz WP, Riedel B, et al. (June 2007).
1641:
1518:
1456:
1388:
1253:
1221:
1190:
1182:
1082:
709:
678:
453:
1772:
Walsh MP, Seto J, Liu EB, Dehghan S, Hudson NR, Lukashev AN, et al. (October 2011).
1278:). A replication-deficient chimpanzee adenovirus vaccine vector (ChAdOx1) is used by the
4061:
2790:
2773:
Wan YY, Leon RP, Marks R, Cham CM, Schaack J, Gajewski TF, et al. (December 2000).
2694:
2515:
2490:
2393:"Functional genetic and biophysical analyses of membrane disruption by human adenovirus"
2260:
2192:
1870:
Singh G, Robinson CM, Dehghan S, Schmidt T, Seto D, Jones MS, et al. (April 2012).
1730:
985:
The fowl adenoviruses are associated with many disease conditions in domestic fowl like
9251:
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8171:
8149:
8117:
8082:
7988:
7953:
7889:
7732:
7721:
7684:
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7219:
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6772:
6735:
6641:
6436:
6020:
5993:
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5477:
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5321:
5310:
5275:
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4731:
4668:
4602:
4580:
4502:
4375:
4147:
4112:
4088:
4045:
4006:
3981:
3934:
3902:"Immune Activation with HIV Vaccines: Implications of the Adenovirus Vector Experience"
3901:
3854:
3829:
3801:
3776:
3752:
3727:
3677:
3652:
3572:
3547:
3327:
3302:
3064:
3037:
2978:"Inclusion Body Hepatitis and Hepatitis Hydropericardium Syndrome in Poultry - Poultry"
2885:
2860:
2750:
2725:
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2593:
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2209:
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2018:
1994:
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1822:
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517:
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352:
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239:
214:
207:
3997:
3792:
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1217:(MDC), and that it is efficiently presented by MDC to M1-specific CD8+ T lymphocytes.
9417:
8303:
8298:
8246:
8139:
8034:
8020:
7848:
7841:
7820:
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7610:
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2809:
2774:
2659:
2284:
1919:
Singh G, Zhou X, Lee JY, Yousuf MA, Ramke M, Ismail AM, et al. (November 2015).
1477:
1302:; the vaccine reportedly prevented mice that were genetically modified to have human
1295:
1209:
are used to target
Adenovirus to certain cell types; a major effort is made to limit
1206:
1144:
1089:
956:
509:
489:
338:
200:
4113:"Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection"
3268:
2475:
1872:"Overreliance on the hexon gene, leading to misclassification of human adenoviruses"
484:
9164:
8692:
8553:
8161:
8106:
8041:
8010:
7977:
7827:
7799:
7617:
7589:
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7554:
7547:
7537:
7373:
7307:
7236:
7084:
7054:
7043:
6990:
6946:
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6917:
6893:
6844:
6756:
6669:
6627:
6466:
6398:
6376:
6356:
6346:
6156:
6072:
5983:
5954:
5942:
5932:
5920:
5910:
5888:
5846:
5836:
5809:
5788:
5766:
5742:
5732:
5710:
5607:
5558:
5519:
5505:
5484:
5231:
5209:
5076:
4978:
4966:
4923:
4912:
4819:
4808:
4773:
4679:
4531:
4386:
4339:
2592:
Singh G, Ismail AM, Lee JY, Ramke M, Lee JS, Dyer DW, et al. (February 2019).
2125:
1677:
1481:
1264:
1235:
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1105:
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900:
662:
658:
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360:
331:
275:
264:
221:
193:
128:
116:
4111:
Auclair S, Liu F, Niu Q, Hou W, Churchyard G, Morgan C, et al. (2018-02-23).
3622:
3432:
3397:
3318:
2938:"Isolation of a novel adenovirus from California sea lions Zalophus californianus"
9325:
4129:
3525:"Could certain COVID-19 vaccines leave people more vulnerable to the AIDS virus?"
3054:
2702:
2560:
2140:
1985:
704:
The early genes are responsible for expressing mainly non-structural, regulatory
9295:
9204:
9153:
9141:
9136:
9129:
9117:
9112:
9091:
9061:
8963:
8802:
8714:
8697:
8632:
8293:
8027:
7806:
7792:
7705:
7561:
7351:
7264:
7257:
7200:
7106:
7027:
6910:
6827:
6793:
6719:
6681:
6662:
6598:
6591:
6422:
6282:
5971:
5799:
5699:
5594:
5444:
5426:
5402:
5265:
5243:
5069:
5047:
5015:
4956:
4745:
4657:
4519:
4469:
4445:
4344:
4301:
4228:
4223:
4202:
4031:"Most COVID-19 Vaccines Won't Affect HIV Risk: Here's What the Science Tells Us"
1936:
1838:
1291:
1066:
1012:
725:
690:
630:
614:
302:
272:
4050:
Proceedings of the
National Academy of Sciences of the United States of America
3743:
3013:
2996:
2779:
Proceedings of the
National Academy of Sciences of the United States of America
1739:
813:
are needed to transport adenoviruses into certain naive/progenitor cell types.
9054:
8838:
8595:
7899:
7855:
7749:
7510:
6319:
6309:
6061:
5661:
4988:
4738:
4291:
4233:
3475:
3252:
2336:
1661:
1508:
1485:
1441:
1432:
1119:
Most people recover from adenovirus infections by themselves, but people with
1006:
880:
865:
721:
593:
557:
527:
290:
9286:
4138:
4079:
3925:
3900:
Fauci AS, Marovich MA, Dieffenbach CW, Hunter E, Buchbinder SP (2014-04-04).
2543:
Lee CS, Bishop ES, Zhang R, Yu X, Farina EM, Yan S, et al. (June 2017).
2506:
9099:
9080:
9047:
9035:
9029:
9008:
8954:
8882:
8853:
8776:
8768:
8730:
8499:
8478:
8384:
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8242:
8095:
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7500:
7456:
6530:
6207:
6179:
5618:
4458:
4430:
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4349:
4070:
3917:
2741:
2268:
2200:
2066:
1460:
1437:
1174:
1148:
1093:
884:
717:
618:
408:: 8, 9, 10, 13, 15, 17, 19, 20, 22, 23, 24, 25, 26, 27, 28, 29, 30, 32, 33,
260:
4156:
4097:
4015:
3959:"Researchers Warn of Heightened Risk of HIV With Certain COVID-19 Vaccines"
3943:
3863:
3810:
3761:
3686:
3581:
3455:
3440:
3405:
3336:
3260:
3150:
3073:
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2894:
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2818:
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2759:
2710:
2629:
2578:
2524:
2467:
2426:
2344:
2276:
2218:
2117:
2052:
2019:"New adenovirus species found in a patient presenting with gastroenteritis"
2003:
1954:
1905:
1856:
1807:
1758:
1669:
1571:
637:
pits. Attachment to αV integrin stimulates cell signaling and thus induces
3197:
2667:
2367:
70:
17:
9312:
9280:
9197:
8844:
8586:
8442:
4306:
4266:
3651:
Zhu FC, Li YH, Guan XH, Hou LH, Wang WJ, Li JX, et al. (June 2020).
3527:. American Association for the Advancement of Science. Science (magazine)
2876:
2408:
2034:
1887:
1789:
1493:
1287:
975:
960:
794:
705:
694:
642:
634:
622:
294:
4044:
Hu H, Eller MA, Zafar S, Zhou Y, Gu M, Wei Z, et al. (2014-09-16).
3176:
Uhnoo I, Svensson L, Wadell G (September 1990). "Enteric adenoviruses".
1005:
and many respiratory conditions. They have also been isolated from wild
462:
or adipogenesis (HAdV-A type 31, HAdV-C type 5, HAdV-D types 9, 36, 37)
8950:
4281:
4276:
4256:
4243:
2861:"Host range, prevalence, and genetic diversity of adenoviruses in bats"
2859:
Li Y, Ge X, Zhang H, Zhou P, Zhu Y, Zhang Y, et al. (April 2010).
1352:
if you can. Unsourced or poorly sourced material may be challenged and
1257:
1185:
or protein. This therapy has been found especially useful in treating
904:
872:
666:
459:
283:
9246:
2911:
Fenner FJ, Gibbs EP, Murphy FA, Rott R, Studdert MJ, White DO (1993).
2610:
1526:
681:
process into two phases: an early and a late phase. In both phases, a
8559:
4296:
3845:
2954:
2937:
2109:
1540:
1452:
1232:
1132:
1073:
and cannot be distinguished from strep except by throat culture), an
936:
912:
854:
748:
581:
505:
497:
9351:
9257:
2458:
2441:
2362:. Molecular Biology. Vol. I. American Society of Microbiology.
2093:
1561:
971:(TAV) (tree shrew adenovirus 1) has been isolated from tree shrews.
437:
Different types/serotypes are associated with different conditions:
30:"ad5", "ad26", "ad35", and "ad48" redirect here. For the years, see
2391:
Moyer CL, Wiethoff CM, Maier O, Smith JG, Nemerow GR (March 2011).
1694:. International Committee on Taxonomy of Viruses (ICTV). March 2021
301:, from mild respiratory infections in young children (known as the
282:
genome. Their name derives from their initial isolation from human
9210:
8969:
8601:
4334:
4261:
4251:
4210:
3284:"Adenovirus looks like flu, acts like flu, but it's not influenza"
2995:
Kumar R, Kumar V, Asthana M, Shukla SK, Chandra R (January 2010).
2247:
Harrison SC (August 2010). "Virology. Looking inside adenovirus".
1427:
1078:
944:
932:
915:
875:
adenoviruses are well known, type 1 and 2. Type 1 (CAdV-1) causes
810:
802:
768:
638:
626:
606:
564:. Although this is significantly larger than other viruses in its
561:
547:
483:
323:
268:
238:
103:
43:
39:
35:
3980:
Buchbinder SP, McElrath MJ, Dieffenbach C, Corey L (2020-10-31).
3878:
3596:"The Oxford/AstraZeneca COVID-19 vaccine: what you need to know"
1650:
Proceedings of the
Society for Experimental Biology and Medicine
1303:
948:
602:
31:
9261:
8215:
8079:
7950:
7440:
6514:
6191:
5591:
4442:
4390:
4175:
3982:"Use of adenovirus type-5 vectored vaccines: a cautionary tale"
1691:
1088:
Some children (especially the youngest) can develop adenovirus
931:
Adenoviruses are also known to cause respiratory infections in
8436:
4171:
3217:
2832:
Chen LH, Wu ZQ, Hu YF, Yang F, Yang J, Jin Q (June 2012). "".
2594:"Divergent Evolution of E1A CR3 in Human Adenovirus Species D"
1449:
1317:
940:
908:
744:
9338:
2175:
Reddy VS, Natchiar SK, Stewart PL, Nemerow GR (August 2010).
2073:. Centers for Disease control and prevention. 31 January 2020
928:
is poorly understood, but research is currently in progress.
2936:
Goldstein T, Colegrove KM, Hanson M, Gulland FM (May 2011).
763:
used in mammalian DNA replication, to replicate the genome.
2177:"Crystal structure of human adenovirus at 3.5 A resolution"
1205:
is an approved cancer treatment. Specific modifications on
798:
712:; to activate other virus genes (such as the virus-encoded
609:
for all other serotypes. There are some reports suggesting
466:
All these types are called Human mastadenovirus A–G by the
305:) to life-threatening multi-organ disease in people with a
1715:"Molecular Evolution of Human Adenovirus (HAdV) Species C"
560:. This allows the virus to theoretically carry 22 to 40
3091:"Adenovirus | Prevention and Treatment | CDC"
1349:
488:
The structure of adenovirus. 1 = penton capsomers, 2 =
9223:
3460:. Liliana Mendonça, Carlos A. Matos. Cham: Springer.
2092:
Voss JD, Atkinson RL, Dhurandhar NV (November 2015).
3350:
Harrington KJ, Vile RG, Pandha HS, eds. (May 2008).
1563:
Adenovirus D26 Structural Model at Atomic
Resolution
1274:
of severe acute respiratory syndrome coronavirus 2 (
496:
Adenoviruses are medium-sized (90–100 nm). The
243:
Adenovirus D26 structural model at atomic resolution
9270:
9187:
9163:
9071:
8994:
8949:
8938:
8767:
8729:
8708:
8676:
8631:
8585:
8464:
8453:
8426:
8253:
8159:
8137:
8126:
8115:
8104:
8093:
8008:
7997:
7986:
7975:
7964:
7937:
7887:
7876:
7780:
7730:
7719:
7693:
7682:
7649:
7638:
7535:
7524:
7498:
7487:
7476:
7465:
7454:
7391:
7361:
7339:
7328:
7288:
7217:
7104:
7093:
7082:
7052:
7041:
7015:
7004:
6978:
6967:
6934:
6891:
6880:
6869:
6825:
6814:
6781:
6770:
6744:
6733:
6679:
6615:
6572:
6561:
6550:
6539:
6528:
6454:
6396:
6385:
6374:
6344:
6333:
6307:
6296:
6249:
6238:
6227:
6216:
6205:
6178:
6130:
6092:
6081:
6070:
6059:
6018:
6007:
5981:
5952:
5930:
5908:
5886:
5875:
5864:
5834:
5823:
5797:
5786:
5775:
5764:
5730:
5719:
5708:
5697:
5649:
5638:
5627:
5616:
5605:
5458:
5436:
5400:
5389:
5382:
5330:
5319:
5308:
5297:
5263:
5241:
5219:
5197:
5186:
5160:
5149:
5123:
5112:
5101:
5057:
5035:
5013:
5002:
4976:
4954:
4943:
4932:
4921:
4910:
4872:
4850:
4839:
4828:
4817:
4806:
4677:
4666:
4655:
4611:
4600:
4589:
4578:
4567:
4529:
4500:
4489:
4478:
4467:
4456:
4429:
4368:
4315:
4242:
4209:
3213:"A killer cold? Even the healthy may be vulnerable"
2358:Flint J, Skalka AM, Rall GF, Racaniello VR (2015).
605:for the group B human adenovirus serotypes and the
293:hosts; in humans, more than 50 distinct adenoviral
2538:
2536:
2534:
1616:"9.11H: Double-Stranded DNA Viruses- Adenoviruses"
1015:adenovirus was isolated from a colony of monkeys.
955:can also cause fatal disease in immunocompromised
3137:"Adenovirus | Clinical Diagnosis | CDC"
1968:Lee B, Damon CF, Platts-Mills JA (October 2020).
3105:"USAMRMC protects Soldiers against unseen enemy"
1112:(inflammation of the urinary bladder—a form of
2726:"Airborne transmission of respiratory viruses"
1348:Please review the contents of the section and
1081:. Adenoviruses types 40 and 41 can also cause
739:) has been found to immortalize primary cells
697:is generated, allowing for the products to be
8227:
4402:
4187:
2834:Bing du Xue Bao = Chinese Journal of Virology
895:) and may cause hepatitis and encephalitis.
767:the cell as a result of virally induced cell
492:capsomers, and 3= viral genome (linear dsDNA)
8:
974:Otarine adenovirus 1 has been isolated from
864:in China. It is most closely related to the
2641:
2639:
1610:
1608:
1606:
1448:would. Two studies found that Ad5-specific
899:(CAdV-2) is one of the potential causes of
9258:
8946:
8726:
8491:Progressive multifocal leukoencephalopathy
8461:
8234:
8220:
8212:
8134:
8123:
8112:
8101:
8090:
8076:
8005:
7994:
7983:
7972:
7961:
7947:
7943:
7884:
7727:
7690:
7646:
7532:
7495:
7484:
7473:
7462:
7451:
7437:
7336:
7101:
7090:
7049:
7012:
6975:
6888:
6877:
6822:
6778:
6741:
6569:
6558:
6547:
6536:
6525:
6511:
6393:
6382:
6341:
6304:
6246:
6235:
6224:
6213:
6202:
6188:
6184:
6089:
6078:
6067:
6015:
5883:
5872:
5831:
5794:
5783:
5772:
5727:
5716:
5705:
5646:
5635:
5624:
5613:
5602:
5588:
5397:
5386:
5327:
5316:
5305:
5194:
5157:
5120:
5109:
5010:
4951:
4940:
4929:
4918:
4847:
4836:
4825:
4814:
4674:
4663:
4608:
4597:
4586:
4575:
4497:
4486:
4475:
4464:
4453:
4439:
4435:
4409:
4395:
4387:
4194:
4180:
4172:
3646:
3644:
3085:
3083:
1604:
1602:
1600:
1598:
1596:
1594:
1592:
1590:
1588:
1586:
1228:that removes almost all the viral genome.
811:coxsackievirus/adenovirus receptors (CARs)
69:
60:
8362:Extranodal NK/T-cell lymphoma, nasal type
4146:
4128:
4087:
4069:
4005:
3933:
3853:
3800:
3751:
3676:
3571:
3518:
3516:
3326:
3063:
3053:
3012:
2953:
2906:
2904:
2884:
2808:
2798:
2749:
2619:
2609:
2568:
2514:
2457:
2416:
2208:
2042:
1993:
1944:
1895:
1846:
1797:
1748:
1738:
1480:based on an Ad5 vector. It was tested in
1472:article reported that China had approved
1231:Adenovirus has been used for delivery of
959:, involving pneumonia and destruction of
297:have been found to cause a wide range of
3617:
3615:
879:, a potentially fatal disease involving
607:coxsackievirus/adenovirus receptor (CAR)
9230:
3834:Human Vaccines & Immunotherapeutics
1552:
1496:trials. It is not known to what extent
848:(Bt-AdV-TJM) is a novel species of the
737:Retinoblastoma tumor suppressor protein
470:, because all are members of the genus
3119:"Default - Stanford Children's Health"
1974:Current Opinion in Infectious Diseases
1494:company's COVID-19 vaccine candidate's
1165:Adenoviruses have long been a popular
3178:Baillière's Clinical Gastroenterology
2915:(2nd ed.). Academic Press, Inc.
1263:Adenovirus have been used to produce
793:Adenoviruses are unusually stable to
665:. After this the DNA associates with
456:(HAdV-F types 40, 41, HAdV-G type 52)
7:
3155:The Lecturio Medical Concept Library
2440:Meier O, Greber UF (February 2004).
2302:(2nd ed.). Hoboken, NJ: Wiley.
1282:that has been approved for use. The
629:. Binding to αV integrin results in
580:Adenoviruses possess a linear dsDNA
500:are composed of one linear piece of
8512:Subacute sclerosing panencephalitis
3457:A handbook of gene and cell therapy
1498:LGBT discrimination in Sierra Leone
1280:Oxford–AstraZeneca COVID-19 vaccine
1156:Use in gene therapy and vaccination
1135:will kill adenoviruses on objects.
322:This family contains the following
2300:Fundamentals of molecular virology
1201:deficiency) and cancer. In China,
356:(including all human adenoviruses)
25:
8831:Severe acute respiratory syndrome
8357:Follicular dendritic cell sarcoma
3358:. Hoboken, N.J.: Wiley. pp.
2683:Infection, Genetics and Evolution
2094:"Role of adenoviruses in obesity"
523:via the receptor on its surface.
267:(without an outer lipid bilayer)
9245:
9233:
8817:Middle East respiratory syndrome
1778:Journal of Clinical Microbiology
1560:Padilla-Sanchez V (2021-07-24),
1525:
1511:
1414:
1322:
513:
90:
79:Transmission electron micrograph
3957:Rosenberg J (25 October 2020).
3495:Chemical & Engineering News
1147:for fever). The antiviral drug
1124:presence of adenovirus type 8.
1108:. Rarely, adenovirus can cause
797:or physical agents and adverse
728:translocation and expression).
530:residues and weighs around 150
8416:Adult T-cell leukemia/lymphoma
8402:Splenic marginal zone lymphoma
1692:"Virus Taxonomy: 2020 Release"
1350:add the appropriate references
1100:. Adenoviruses can also cause
1:
3998:10.1016/S0140-6736(20)32156-5
3877:Collins S (9 December 2020).
3793:10.1016/S0140-6736(20)31866-3
3669:10.1016/s0140-6736(20)31208-3
3564:10.1016/S0140-6736(20)31604-4
3433:10.1016/j.vaccine.2009.09.021
3398:10.1016/j.vaccine.2007.01.117
3319:10.1016/j.vaccine.2009.09.055
2942:Diseases of Aquatic Organisms
2141:"Adenoviruses (Adenoviridae)"
1069:(which may look exactly like
444:(mainly species HAdV-B and C)
8621:Tropical spastic paraparesis
8526:Lymphocytic choriomeningitis
4130:10.1371/journal.ppat.1006888
3190:10.1016/0950-3528(90)90053-j
3055:10.1371/journal.ppat.1002155
3001:Journal of Wildlife Diseases
2703:10.1016/j.meegid.2008.01.002
2660:10.1016/0042-6822(71)90355-2
2561:10.1016/j.gendis.2017.04.001
2446:The Journal of Gene Medicine
1986:10.1097/QCO.0000000000000663
81:of two adenovirus particles
8984:Cytomegalovirus esophagitis
8904:Human parainfluenza viruses
8577:Ramsay Hunt syndrome type 2
3523:Cohen J (19 October 2020).
3211:Burkholder A (2007-12-19).
2139:Harrach B, Benkő M (2021).
2098:Reviews in Medical Virology
1937:10.1016/j.virol.2015.08.018
1839:10.1016/j.virol.2010.10.020
1335:reliable medical references
1116:—with blood in the urine).
918:was a common complication.
877:infectious canine hepatitis
693:compatible with the host's
289:They have a broad range of
259:) are medium-sized (90–100
9445:
4029:Buhl L (2 December 2020).
3744:10.1016/j.cell.2020.08.026
3282:Fox M (January 28, 2018).
3014:10.7589/0090-3558-46.1.272
1740:10.1038/s41598-018-37249-4
1245:
1054:
1022:
838:
820:
724:activity, and blockage of
633:of the virus particle via
541:
29:
8648:Cytomegalovirus retinitis
8089:
8075:
7960:
7946:
7450:
7436:
6524:
6510:
6201:
6187:
5601:
5587:
4452:
4438:
3253:10.1007/s00705-018-3942-3
2337:10.1016/j.tim.2004.02.005
2147:. Vol. 2. Elsevier.
2067:"Adenovirus | Home | CDC"
1662:10.3181/00379727-84-20714
1541:VA (viral associated) RNA
1341:or relies too heavily on
991:hydropericardium syndrome
805:routes and via aerosols (
775:Multiplicity reactivation
189:
184:
85:
77:
68:
63:
8750:Infectious mononucleosis
8567:Chandipura vesiculovirus
8397:Hepatocellular carcinoma
8342:Nasopharyngeal carcinoma
8275:Hepatocellular carcinoma
2507:10.15252/embj.2023114162
2442:"Adenovirus endocytosis"
2145:Encyclopedia of Virology
1284:Janssen COVID-19 vaccine
987:inclusion body hepatitis
396:, 16, 21, 34, 35, 50, 55
8546:Encephalitis lethargica
8247:viral systemic diseases
4071:10.1073/pnas.1400446111
3918:10.1126/science.1250672
3489:Cross R (12 May 2020).
3354:Viral Therapy of Cancer
2742:10.1126/science.abd9149
2269:10.1126/science.1194922
2201:10.1126/science.1187292
1215:myeloid dendritic cells
1114:urinary tract infection
8918:Human orthopneumovirus
8572:Herpesviral meningitis
8533:Arbovirus encephalitis
2800:10.1073/pnas.250356297
2452:(Suppl 1): S152–S163.
2360:Principles of Virology
2325:Trends in Microbiology
1572:10.5281/zenodo.5132873
1314:HIV infection concerns
980:Zalophus californianus
926:Adenovirus in reptiles
829:Adenovirus serotype 14
553:
504:inside an icosahedral
493:
307:weakened immune system
244:
56:AD 35 (disambiguation)
46:. For other uses, see
8376:Merkel-cell carcinoma
2368:10.1128/9781555818951
1484:, which had high HIV
1246:Further information:
807:airborne transmission
687:alternatively spliced
551:
487:
242:
52:AD26 (disambiguation)
48:AD-5 (disambiguation)
9021:Adenovirus infection
8485:Human polyomavirus 2
8314:Oropharyngeal cancer
4422:virus classification
3824:Fausther-Bovendo H,
3663:(10240): 1845–1854.
3241:Archives of Virology
2877:10.1128/JVI.02497-09
2549:Genes & Diseases
2409:10.1128/JVI.02321-10
2035:10.1128/JVI.02650-06
1888:10.1128/jvi.06969-11
1790:10.1128/JCM.00156-11
1248:Viral vector vaccine
1203:oncolytic adenovirus
1110:hemorrhagic cystitis
1057:Adenovirus infection
852:genus isolated from
823:Adenovirus infection
743:allowing E1B (binds
677:is separated by the
621:) interacts with an
87:Virus classification
8607:Post-polio syndrome
8243:Infectious diseases
7404:Permutotetraviridae
5163:Orthopolintovirales
4638:Malacoherpesviridae
4062:2014PNAS..11113439H
2913:Veterinary Virology
2865:Journal of Virology
2791:2000PNAS...9713784W
2785:(25): 13784–13789.
2695:2008InfGE...8..267M
2397:Journal of Virology
2298:Acheson NH (2011).
2261:2010Sci...329.1026H
2193:2010Sci...329.1071R
2023:Journal of Virology
1876:Journal of Virology
1731:2019NatSR...9.1039D
953:Equine adenovirus 1
897:Canine adenovirus 2
691:monocistronic mRNAs
502:double-stranded DNA
442:respiratory disease
280:double-stranded DNA
8740:Epstein–Barr virus
8710:Respiratory system
8347:Burkitt's lymphoma
5722:Malgrandaviricetes
5357:Sphaerolipoviridae
5343:Matshushitaviridae
4935:Nucleocytoviricota
3992:(10260): e68–e69.
3787:(10255): 887–897.
3738:(1): 169–184.e13.
3558:(10249): 467–478.
3454:NĂłbrega C (2020).
2736:(6558): eabd9149.
2234:. August 28, 2010.
1719:Scientific Reports
1620:Biology LibreTexts
1446:ImmunityBio's hAd5
1290:, ImmunityBio and
1272:spike glycoprotein
1199:alpha1-antitrypsin
1025:Adenovirus vaccine
1009:(Milvus migrans).
861:Scotophilus kuhlii
846:Bat adenovirus TJM
683:primary transcript
554:
494:
245:
9411:
9410:
9264:Taxon identifiers
9221:
9220:
9183:
9182:
8934:
8933:
8865:Influenza virus A
8782:Human coronavirus
8672:
8671:
8662:Herpes of the eye
8209:
8208:
8205:
8204:
8201:
8200:
8197:
8196:
8193:
8192:
8189:
8188:
8185:
8184:
8181:
8180:
8071:
8070:
8067:
8066:
8063:
8062:
8059:
8058:
8055:
8054:
8051:
8050:
7933:
7932:
7929:
7928:
7925:
7924:
7921:
7920:
7917:
7916:
7913:
7912:
7909:
7908:
7879:Yunchangviricetes
7872:
7871:
7715:
7714:
7678:
7677:
7634:
7633:
7520:
7519:
7432:
7431:
7428:
7427:
7424:
7423:
7420:
7419:
7387:
7386:
7383:
7382:
7324:
7323:
7078:
7077:
7074:
7073:
7037:
7036:
7000:
6999:
6963:
6962:
6865:
6864:
6861:
6860:
6838:Carmotetraviridae
6810:
6809:
6766:
6765:
6729:
6728:
6713:Gammaflexiviridae
6706:Deltaflexiviridae
6692:Alphaflexiviridae
6585:Alphatetraviridae
6506:
6505:
6502:
6501:
6498:
6497:
6494:
6493:
6450:
6449:
6446:
6445:
6370:
6369:
6366:
6365:
6329:
6328:
6292:
6291:
6241:Chrymotiviricetes
6174:
6173:
6170:
6169:
6166:
6165:
6126:
6125:
6122:
6121:
6118:
6117:
6114:
6113:
6055:
6054:
6051:
6050:
6047:
6046:
6003:
6002:
5899:Bacilladnaviridae
5860:
5859:
5856:
5855:
5819:
5818:
5760:
5759:
5756:
5755:
5752:
5751:
5693:
5692:
5689:
5688:
5685:
5684:
5583:
5582:
5579:
5578:
5575:
5574:
5541:Portogloboviridae
5454:
5453:
5378:
5377:
5374:
5373:
5370:
5369:
5366:
5365:
5293:
5292:
5289:
5288:
5285:
5284:
5182:
5181:
5145:
5144:
5104:Preplasmiviricota
5097:
5096:
5093:
5092:
4998:
4997:
4906:
4905:
4902:
4901:
4898:
4897:
4894:
4893:
4802:
4801:
4798:
4797:
4794:
4793:
4790:
4789:
4697:Autographiviridae
4651:
4650:
4647:
4646:
4624:Alloherpesviridae
4563:
4562:
4559:
4558:
4555:
4554:
4551:
4550:
4384:
4383:
3467:978-3-030-41333-0
3369:978-0-470-01922-1
3247:(10): 2895–2897.
3125:on April 3, 2020.
2982:Veterinary Manual
2922:978-0-12-253056-2
2611:10.3390/v11020143
2377:978-1-55581-933-0
2309:978-0-470-90059-8
2154:978-0-12-814516-6
1466:By comparison, a
1423:
1422:
1399:
1300:ChAd-SARS-CoV-2-S
1268:COVID-19 vaccines
1181:, in the form of
995:Egg drop syndrome
969:Tupaia adenovirus
868:and canine AdVs.
761:Okazaki fragments
651:Adenovirus genome
544:Adenovirus genome
237:
236:
142:Preplasmiviricota
27:Family of viruses
16:(Redirected from
9436:
9404:
9403:
9391:
9390:
9381:
9380:
9368:
9367:
9355:
9354:
9342:
9341:
9329:
9328:
9316:
9315:
9306:
9305:
9304:
9291:
9290:
9289:
9259:
9250:
9249:
9238:
9237:
9236:
9229:
8947:
8942:digestive system
8859:Orthomyxoviridae
8825:SARS coronavirus
8811:MERS coronavirus
8727:
8539:Orthomyxoviridae
8462:
8428:Immune disorders
8352:Hodgkin lymphoma
8328:Kaposi's sarcoma
8236:
8229:
8222:
8213:
8135:
8124:
8113:
8102:
8091:
8083:dsDNA-RT viruses
8077:
8006:
7995:
7984:
7973:
7962:
7954:ssRNA-RT viruses
7948:
7944:
7885:
7728:
7696:Serpentovirales
7691:
7669:Orthomyxoviridae
7647:
7597:Peribunyaviridae
7533:
7496:
7490:Chunqiuviricetes
7485:
7474:
7463:
7452:
7444:(–)ssRNA viruses
7438:
7337:
7180:Nanghoshaviridae
7102:
7091:
7065:Botourmiaviridae
7050:
7013:
7007:Howeltoviricetes
6976:
6970:Amabiliviricetes
6889:
6878:
6823:
6779:
6742:
6699:Betaflexiviridae
6570:
6559:
6548:
6537:
6526:
6518:(+)ssRNA viruses
6512:
6430:Picobirnaviridae
6394:
6388:Duplopiviricetes
6383:
6342:
6336:Vidaverviricetes
6305:
6299:Resentoviricetes
6269:Megabirnaviridae
6247:
6236:
6230:Duplornaviricota
6225:
6214:
6203:
6189:
6185:
6090:
6084:Huolimaviricetes
6079:
6068:
6016:
6010:Repensiviricetes
5884:
5873:
5867:Cressdnaviricota
5832:
5795:
5784:
5773:
5728:
5717:
5706:
5647:
5636:
5625:
5614:
5603:
5589:
5398:
5387:
5328:
5317:
5306:
5195:
5189:Tectiliviricetes
5158:
5152:Polintoviricetes
5126:Priklausovirales
5121:
5110:
5084:Marseilleviridae
5011:
4952:
4941:
4930:
4919:
4885:Papillomaviridae
4875:Zurhausenvirales
4848:
4837:
4826:
4815:
4690:Ackermannviridae
4675:
4664:
4609:
4598:
4587:
4576:
4542:Tristromaviridae
4513:Lipothrixviridae
4498:
4487:
4476:
4465:
4454:
4440:
4436:
4411:
4404:
4397:
4388:
4325:Acute bronchitis
4287:Nasal congestion
4272:Loss of appetite
4196:
4189:
4182:
4173:
4161:
4160:
4150:
4132:
4108:
4102:
4101:
4091:
4073:
4056:(37): 13439–44.
4041:
4035:
4034:
4026:
4020:
4019:
4009:
3977:
3971:
3970:
3968:
3966:
3954:
3948:
3947:
3937:
3897:
3891:
3890:
3888:
3886:
3874:
3868:
3867:
3857:
3846:10.4161/hv.29594
3821:
3815:
3814:
3804:
3772:
3766:
3765:
3755:
3723:
3717:
3716:
3714:
3712:
3707:. 27 August 2020
3697:
3691:
3690:
3680:
3648:
3639:
3638:
3636:
3634:
3619:
3610:
3609:
3607:
3606:
3592:
3586:
3585:
3575:
3543:
3537:
3536:
3534:
3532:
3520:
3511:
3510:
3508:
3506:
3486:
3480:
3479:
3451:
3445:
3444:
3416:
3410:
3409:
3380:
3374:
3373:
3357:
3347:
3341:
3340:
3330:
3298:
3292:
3291:
3279:
3273:
3272:
3235:
3229:
3228:
3226:
3225:
3208:
3202:
3201:
3173:
3167:
3166:
3164:
3162:
3147:
3141:
3140:
3133:
3127:
3126:
3121:. Archived from
3115:
3109:
3108:
3101:
3095:
3094:
3087:
3078:
3077:
3067:
3057:
3033:
3027:
3026:
3016:
2992:
2986:
2985:
2974:
2968:
2967:
2957:
2955:10.3354/dao02321
2933:
2927:
2926:
2908:
2899:
2898:
2888:
2856:
2850:
2849:
2829:
2823:
2822:
2812:
2802:
2770:
2764:
2763:
2753:
2721:
2715:
2714:
2678:
2672:
2671:
2643:
2634:
2633:
2623:
2613:
2589:
2583:
2582:
2572:
2540:
2529:
2528:
2518:
2495:The EMBO Journal
2486:
2480:
2479:
2461:
2437:
2431:
2430:
2420:
2403:(6): 2631–2641.
2388:
2382:
2381:
2355:
2349:
2348:
2320:
2314:
2313:
2295:
2289:
2288:
2255:(5995): 1026–7.
2244:
2238:
2235:
2225:Lay summary in:
2222:
2212:
2187:(5995): 1071–5.
2172:
2166:
2165:
2163:
2161:
2136:
2130:
2129:
2110:10.1002/rmv.1852
2089:
2083:
2082:
2080:
2078:
2063:
2057:
2056:
2046:
2014:
2008:
2007:
1997:
1965:
1959:
1958:
1948:
1916:
1910:
1909:
1899:
1867:
1861:
1860:
1850:
1818:
1812:
1811:
1801:
1769:
1763:
1762:
1752:
1742:
1710:
1704:
1703:
1701:
1699:
1688:
1682:
1681:
1638:
1632:
1631:
1629:
1627:
1612:
1581:
1580:
1579:
1578:
1557:
1535:
1530:
1529:
1521:
1516:
1515:
1514:
1418:
1417:
1409:
1406:
1400:
1398:
1357:
1326:
1325:
1318:
1179:targeted therapy
1121:immunodeficiency
1102:viral meningitis
1003:Gizzard erosions
999:Quail bronchitis
584:and are able to
402:: 1, 2, 5, 6, 57
250:(members of the
154:Tectiliviricetes
95:
94:
73:
61:
21:
9444:
9443:
9439:
9438:
9437:
9435:
9434:
9433:
9414:
9413:
9412:
9407:
9399:
9394:
9386:
9384:
9376:
9371:
9363:
9358:
9350:
9345:
9337:
9332:
9324:
9319:
9311:
9309:
9300:
9299:
9294:
9285:
9284:
9279:
9266:
9256:
9244:
9234:
9232:
9224:
9222:
9217:
9179:
9159:
9067:
9041:Gastroenteritis
8999:
8996:Gastroenteritis
8990:
8978:Cytomegalovirus
8941:
8930:
8898:Paramyxoviridae
8887:Avian influenza
8763:
8758:Cytomegalovirus
8722:viral pneumonia
8720:
8717:nasopharyngitis
8716:
8713:
8704:
8668:
8642:Cytomegalovirus
8627:
8581:
8469:
8456:
8449:
8422:
8289:Cervical cancer
8249:
8240:
8210:
8177:
8155:
8129:Revtraviricetes
8085:
8047:
8000:Revtraviricetes
7956:
7905:
7868:
7835:Paramyxoviridae
7783:Mononegavirales
7776:
7757:Crepuscuviridae
7711:
7674:
7652:Articulavirales
7641:Insthoviricetes
7630:
7516:
7479:Negarnaviricota
7446:
7416:
7379:
7357:
7331:Stelpaviricetes
7320:
7284:
7279:Polycipiviridae
7272:Dicistroviridae
7213:
7096:Pisoniviricetes
7070:
7033:
6996:
6959:
6930:
6857:
6817:Tolucaviricetes
6806:
6762:
6747:Amarillovirales
6725:
6675:
6635:Closteroviridae
6618:Martellivirales
6611:
6553:Kitrinoviricota
6520:
6490:
6474:Polymycoviridae
6442:
6362:
6325:
6288:
6197:
6162:
6150:Finnlakeviridae
6110:
6105:Pleolipoviridae
6043:
5999:
5977:
5948:
5926:
5904:
5852:
5826:Quintoviricetes
5815:
5748:
5681:
5597:
5571:
5450:
5432:
5362:
5333:Halopanivirales
5281:
5259:
5237:
5215:
5178:
5141:
5115:Maveriviricetes
5089:
5053:
5031:
5026:Phycodnaviridae
4994:
4972:
4946:Pokkesviricetes
4890:
4868:
4842:Papovaviricetes
4786:
4753:Rountreeviridae
4643:
4547:
4525:
4448:
4425:
4415:
4385:
4380:
4376:Antiviral drugs
4364:
4311:
4238:
4205:
4200:
4170:
4165:
4164:
4123:(2): e1006888.
4110:
4109:
4105:
4043:
4042:
4038:
4028:
4027:
4023:
3979:
3978:
3974:
3964:
3962:
3956:
3955:
3951:
3912:(6179): 49–51.
3899:
3898:
3894:
3884:
3882:
3876:
3875:
3871:
3840:(10): 2875–84.
3823:
3822:
3818:
3774:
3773:
3769:
3725:
3724:
3720:
3710:
3708:
3699:
3698:
3694:
3650:
3649:
3642:
3632:
3630:
3627:Clinical Trials
3621:
3620:
3613:
3604:
3602:
3594:
3593:
3589:
3545:
3544:
3540:
3530:
3528:
3522:
3521:
3514:
3504:
3502:
3488:
3487:
3483:
3468:
3453:
3452:
3448:
3427:(52): 7385–93.
3418:
3417:
3413:
3392:(19): 3809–15.
3382:
3381:
3377:
3370:
3349:
3348:
3344:
3313:(50): 7116–24.
3300:
3299:
3295:
3281:
3280:
3276:
3237:
3236:
3232:
3223:
3221:
3210:
3209:
3205:
3175:
3174:
3170:
3160:
3158:
3157:. 30 April 2020
3149:
3148:
3144:
3135:
3134:
3130:
3117:
3116:
3112:
3103:
3102:
3098:
3089:
3088:
3081:
3048:(7): e1002155.
3035:
3034:
3030:
2994:
2993:
2989:
2976:
2975:
2971:
2935:
2934:
2930:
2923:
2910:
2909:
2902:
2858:
2857:
2853:
2831:
2830:
2826:
2772:
2771:
2767:
2723:
2722:
2718:
2680:
2679:
2675:
2645:
2644:
2637:
2591:
2590:
2586:
2542:
2541:
2532:
2501:(19): e114162.
2488:
2487:
2483:
2459:10.1002/jgm.553
2439:
2438:
2434:
2390:
2389:
2385:
2378:
2357:
2356:
2352:
2322:
2321:
2317:
2310:
2297:
2296:
2292:
2246:
2245:
2241:
2226:
2174:
2173:
2169:
2159:
2157:
2155:
2138:
2137:
2133:
2091:
2090:
2086:
2076:
2074:
2065:
2064:
2060:
2029:(11): 5978–84.
2016:
2015:
2011:
1967:
1966:
1962:
1918:
1917:
1913:
1869:
1868:
1864:
1820:
1819:
1815:
1784:(10): 3482–90.
1771:
1770:
1766:
1712:
1711:
1707:
1697:
1695:
1690:
1689:
1685:
1640:
1639:
1635:
1625:
1623:
1614:
1613:
1584:
1576:
1574:
1559:
1558:
1554:
1549:
1531:
1524:
1519:Medicine portal
1517:
1512:
1510:
1507:
1457:Cytomegalovirus
1419:
1415:
1410:
1404:
1401:
1358:
1347:
1343:primary sources
1327:
1323:
1316:
1250:
1244:
1222:Jesse Gelsinger
1191:cystic fibrosis
1183:recombinant DNA
1163:
1158:
1141:
1083:gastroenteritis
1059:
1053:
1044:
1027:
1021:
843:
837:
825:
819:
791:
786:
777:
679:DNA replication
673:The adenovirus
635:clathrin-coated
578:
566:Baltimore group
546:
540:
482:
454:gastroenteritis
377:
320:
315:
89:
59:
28:
23:
22:
15:
12:
11:
5:
9442:
9440:
9432:
9431:
9429:Virus families
9426:
9416:
9415:
9409:
9408:
9406:
9405:
9392:
9382:
9369:
9356:
9343:
9330:
9317:
9307:
9292:
9276:
9274:
9268:
9267:
9262:
9255:
9254:
9242:
9219:
9218:
9216:
9215:
9214:
9213:
9201:
9193:
9191:
9185:
9184:
9181:
9180:
9178:
9177:
9169:
9167:
9161:
9160:
9158:
9157:
9145:
9133:
9121:
9109:
9102:
9096:
9095:
9083:
9077:
9075:
9069:
9068:
9066:
9065:
9058:
9051:
9044:
9032:
9026:
9025:
9024:
9023:
9011:
9005:
9003:
8992:
8991:
8989:
8988:
8987:
8986:
8974:
8973:
8972:
8959:
8957:
8944:
8936:
8935:
8932:
8931:
8929:
8928:
8921:
8914:
8913:
8912:
8892:
8891:
8890:
8889:
8850:
8849:
8848:
8847:
8835:
8834:
8833:
8821:
8820:
8819:
8807:
8806:
8805:
8773:
8771:
8765:
8764:
8762:
8761:
8754:
8753:
8752:
8735:
8733:
8724:
8706:
8705:
8703:
8702:
8701:
8700:
8695:
8682:
8680:
8678:Cardiovascular
8674:
8673:
8670:
8669:
8667:
8666:
8665:
8664:
8652:
8651:
8650:
8637:
8635:
8629:
8628:
8626:
8625:
8624:
8623:
8611:
8610:
8609:
8604:
8591:
8589:
8583:
8582:
8580:
8579:
8574:
8569:
8564:
8563:
8562:
8550:
8549:
8548:
8535:
8530:
8529:
8528:
8516:
8515:
8514:
8502:
8496:
8495:
8494:
8493:
8481:
8475:
8473:
8459:
8457:nervous system
8451:
8450:
8448:
8447:
8446:
8445:
8432:
8430:
8424:
8423:
8421:
8420:
8419:
8418:
8406:
8405:
8404:
8399:
8387:
8381:
8380:
8379:
8378:
8366:
8365:
8364:
8359:
8354:
8349:
8344:
8332:
8331:
8330:
8318:
8317:
8316:
8311:
8309:Vaginal cancer
8306:
8301:
8296:
8291:
8279:
8278:
8277:
8265:
8259:
8257:
8251:
8250:
8241:
8239:
8238:
8231:
8224:
8216:
8207:
8206:
8203:
8202:
8199:
8198:
8195:
8194:
8191:
8190:
8187:
8186:
8183:
8182:
8179:
8178:
8176:
8175:
8172:Caulimoviridae
8167:
8165:
8157:
8156:
8154:
8153:
8150:Hepadnaviridae
8145:
8143:
8132:
8121:
8118:Artverviricota
8110:
8099:
8087:
8086:
8080:
8073:
8072:
8069:
8068:
8065:
8064:
8061:
8060:
8057:
8056:
8053:
8052:
8049:
8048:
8046:
8045:
8038:
8031:
8024:
8016:
8014:
8003:
7992:
7989:Artverviricota
7981:
7970:
7958:
7957:
7951:
7941:
7935:
7934:
7931:
7930:
7927:
7926:
7923:
7922:
7919:
7918:
7915:
7914:
7911:
7910:
7907:
7906:
7904:
7903:
7895:
7893:
7890:Goujianvirales
7882:
7874:
7873:
7870:
7869:
7867:
7866:
7859:
7852:
7845:
7838:
7831:
7824:
7817:
7810:
7803:
7796:
7788:
7786:
7778:
7777:
7775:
7774:
7767:
7760:
7753:
7746:
7738:
7736:
7733:Jingchuvirales
7725:
7722:Monjiviricetes
7717:
7716:
7713:
7712:
7710:
7709:
7701:
7699:
7688:
7685:Milneviricetes
7680:
7679:
7676:
7675:
7673:
7672:
7665:
7657:
7655:
7644:
7636:
7635:
7632:
7631:
7629:
7628:
7621:
7614:
7607:
7600:
7593:
7586:
7579:
7576:Leishbuviridae
7572:
7565:
7558:
7551:
7543:
7541:
7530:
7527:Ellioviricetes
7522:
7521:
7518:
7517:
7515:
7514:
7506:
7504:
7493:
7482:
7471:
7460:
7448:
7447:
7441:
7434:
7433:
7430:
7429:
7426:
7425:
7422:
7421:
7418:
7417:
7415:
7414:
7411:Sarthroviridae
7407:
7395:
7393:
7389:
7388:
7385:
7384:
7381:
7380:
7378:
7377:
7369:
7367:
7359:
7358:
7356:
7355:
7347:
7345:
7334:
7326:
7325:
7322:
7321:
7319:
7318:
7311:
7304:
7301:Alvernaviridae
7296:
7294:
7286:
7285:
7283:
7282:
7275:
7268:
7261:
7254:
7247:
7244:Solinviviridae
7240:
7233:
7230:Picornaviridae
7225:
7223:
7220:Picornavirales
7215:
7214:
7212:
7211:
7204:
7197:
7190:
7187:Nanhypoviridae
7183:
7176:
7169:
7162:
7159:Medioniviridae
7155:
7148:
7141:
7134:
7131:Cremegaviridae
7127:
7120:
7112:
7110:
7099:
7088:
7080:
7079:
7076:
7075:
7072:
7071:
7069:
7068:
7060:
7058:
7047:
7039:
7038:
7035:
7034:
7032:
7031:
7023:
7021:
7010:
7002:
7001:
6998:
6997:
6995:
6994:
6986:
6984:
6981:Wolframvirales
6973:
6965:
6964:
6961:
6960:
6958:
6957:
6950:
6942:
6940:
6932:
6931:
6929:
6928:
6921:
6914:
6907:
6899:
6897:
6886:
6875:
6867:
6866:
6863:
6862:
6859:
6858:
6856:
6855:
6848:
6841:
6833:
6831:
6820:
6812:
6811:
6808:
6807:
6805:
6804:
6801:Sinhaliviridae
6797:
6789:
6787:
6776:
6773:Magsaviricetes
6768:
6767:
6764:
6763:
6761:
6760:
6752:
6750:
6739:
6736:Flasuviricetes
6731:
6730:
6727:
6726:
6724:
6723:
6716:
6709:
6702:
6695:
6687:
6685:
6677:
6676:
6674:
6673:
6666:
6659:
6652:
6645:
6642:Endornaviridae
6638:
6631:
6623:
6621:
6613:
6612:
6610:
6609:
6602:
6595:
6588:
6580:
6578:
6567:
6556:
6545:
6534:
6522:
6521:
6515:
6508:
6507:
6504:
6503:
6500:
6499:
6496:
6495:
6492:
6491:
6489:
6488:
6485:Botybirnavirus
6477:
6470:
6458:
6456:
6452:
6451:
6448:
6447:
6444:
6443:
6441:
6440:
6437:Partitiviridae
6433:
6426:
6419:
6416:Curvulaviridae
6412:
6404:
6402:
6391:
6380:
6372:
6371:
6368:
6367:
6364:
6363:
6361:
6360:
6352:
6350:
6339:
6331:
6330:
6327:
6326:
6324:
6323:
6315:
6313:
6302:
6294:
6293:
6290:
6289:
6287:
6286:
6279:
6272:
6265:
6257:
6255:
6244:
6233:
6222:
6211:
6199:
6198:
6192:
6182:
6176:
6175:
6172:
6171:
6168:
6167:
6164:
6163:
6161:
6160:
6153:
6146:
6134:
6132:
6128:
6127:
6124:
6123:
6120:
6119:
6116:
6115:
6112:
6111:
6109:
6108:
6100:
6098:
6087:
6076:
6065:
6057:
6056:
6053:
6052:
6049:
6048:
6045:
6044:
6042:
6041:
6034:
6026:
6024:
6021:Geplafuvirales
6013:
6005:
6004:
6001:
6000:
5998:
5997:
5994:Redondoviridae
5989:
5987:
5979:
5978:
5976:
5975:
5968:
5960:
5958:
5950:
5949:
5947:
5946:
5938:
5936:
5928:
5927:
5925:
5924:
5916:
5914:
5906:
5905:
5903:
5902:
5894:
5892:
5881:
5870:
5862:
5861:
5858:
5857:
5854:
5853:
5851:
5850:
5842:
5840:
5829:
5821:
5820:
5817:
5816:
5814:
5813:
5805:
5803:
5792:
5781:
5770:
5762:
5761:
5758:
5757:
5754:
5753:
5750:
5749:
5747:
5746:
5738:
5736:
5725:
5714:
5703:
5695:
5694:
5691:
5690:
5687:
5686:
5683:
5682:
5680:
5679:
5676:Plectroviridae
5672:
5669:Paulinoviridae
5665:
5657:
5655:
5644:
5641:Faserviricetes
5633:
5630:Hofneiviricota
5622:
5611:
5599:
5598:
5592:
5585:
5584:
5581:
5580:
5577:
5576:
5573:
5572:
5570:
5569:
5562:
5551:
5544:
5537:
5534:Polydnaviridae
5530:
5523:
5516:
5509:
5502:
5499:Globuloviridae
5495:
5492:Fuselloviridae
5488:
5481:
5478:Bicaudaviridae
5474:
5471:Ampullaviridae
5462:
5460:
5456:
5455:
5452:
5451:
5449:
5448:
5440:
5438:
5434:
5433:
5431:
5430:
5423:
5420:Hytrosaviridae
5416:
5408:
5406:
5395:
5392:Naldaviricetes
5384:
5380:
5379:
5376:
5375:
5372:
5371:
5368:
5367:
5364:
5363:
5361:
5360:
5353:
5346:
5338:
5336:
5325:
5322:Laserviricetes
5314:
5311:Dividoviricota
5303:
5295:
5294:
5291:
5290:
5287:
5286:
5283:
5282:
5280:
5279:
5276:Corticoviridae
5271:
5269:
5261:
5260:
5258:
5257:
5249:
5247:
5239:
5238:
5236:
5235:
5227:
5225:
5217:
5216:
5214:
5213:
5205:
5203:
5192:
5184:
5183:
5180:
5179:
5177:
5176:
5168:
5166:
5155:
5147:
5146:
5143:
5142:
5140:
5139:
5131:
5129:
5118:
5107:
5099:
5098:
5095:
5094:
5091:
5090:
5088:
5087:
5080:
5073:
5065:
5063:
5060:Pimascovirales
5055:
5054:
5052:
5051:
5043:
5041:
5033:
5032:
5030:
5029:
5021:
5019:
5008:
5000:
4999:
4996:
4995:
4993:
4992:
4984:
4982:
4974:
4973:
4971:
4970:
4962:
4960:
4949:
4938:
4927:
4916:
4908:
4907:
4904:
4903:
4900:
4899:
4896:
4895:
4892:
4891:
4889:
4888:
4880:
4878:
4870:
4869:
4867:
4866:
4863:Polyomaviridae
4858:
4856:
4845:
4834:
4823:
4812:
4804:
4803:
4800:
4799:
4796:
4795:
4792:
4791:
4788:
4787:
4785:
4784:
4777:
4770:
4763:
4760:Salasmaviridae
4756:
4749:
4742:
4735:
4732:Herelleviridae
4728:
4721:
4718:Drexlerviridae
4714:
4711:Demerecviridae
4707:
4700:
4693:
4685:
4683:
4672:
4669:Caudoviricetes
4661:
4653:
4652:
4649:
4648:
4645:
4644:
4642:
4641:
4634:
4627:
4619:
4617:
4606:
4603:Herviviricetes
4595:
4584:
4581:Heunggongvirae
4573:
4565:
4564:
4561:
4560:
4557:
4556:
4553:
4552:
4549:
4548:
4546:
4545:
4537:
4535:
4527:
4526:
4524:
4523:
4516:
4508:
4506:
4503:Ligamenvirales
4495:
4484:
4473:
4462:
4450:
4449:
4443:
4433:
4427:
4426:
4416:
4414:
4413:
4406:
4399:
4391:
4382:
4381:
4379:
4378:
4372:
4370:
4366:
4365:
4363:
4362:
4357:
4352:
4347:
4342:
4337:
4332:
4327:
4321:
4319:
4313:
4312:
4310:
4309:
4304:
4299:
4294:
4289:
4284:
4279:
4274:
4269:
4264:
4259:
4254:
4248:
4246:
4240:
4239:
4237:
4236:
4231:
4226:
4221:
4215:
4213:
4207:
4206:
4201:
4199:
4198:
4191:
4184:
4176:
4169:
4168:External links
4166:
4163:
4162:
4117:PLOS Pathogens
4103:
4036:
4021:
3972:
3949:
3892:
3869:
3816:
3767:
3718:
3692:
3640:
3629:. 22 June 2020
3611:
3587:
3538:
3512:
3481:
3466:
3446:
3411:
3375:
3368:
3342:
3293:
3274:
3230:
3203:
3168:
3142:
3128:
3110:
3096:
3079:
3042:PLOS Pathogens
3028:
2987:
2969:
2928:
2921:
2900:
2871:(8): 3889–97.
2851:
2824:
2765:
2716:
2673:
2635:
2584:
2530:
2481:
2432:
2383:
2376:
2350:
2315:
2308:
2290:
2239:
2237:
2236:
2167:
2153:
2131:
2084:
2058:
2009:
1980:(5): 398–403.
1960:
1911:
1862:
1813:
1764:
1705:
1683:
1633:
1622:. 25 June 2017
1582:
1551:
1550:
1548:
1545:
1544:
1543:
1537:
1536:
1533:Viruses portal
1522:
1506:
1503:
1421:
1420:
1413:
1411:
1364:"Adenoviridae"
1330:
1328:
1321:
1315:
1312:
1243:
1240:
1226:gutless vector
1211:hepatotoxicity
1207:fiber proteins
1189:disease (e.g.
1162:
1159:
1157:
1154:
1140:
1137:
1098:whooping cough
1063:conjunctivitis
1055:Main article:
1052:
1049:
1043:
1040:
1023:Main article:
1020:
1017:
965:salivary gland
893:Vulpes lagopus
850:Mastadenovirus
841:DA2PPC Vaccine
836:
833:
821:Main article:
818:
815:
790:
787:
785:
782:
776:
773:
720:, blockage of
714:DNA polymerase
613:molecules and
577:
574:
542:Main article:
539:
536:
510:hexon proteins
481:
478:
473:Mastadenovirus
464:
463:
457:
451:
450:(HAdV-B and D)
448:conjunctivitis
445:
435:
434:
428:
419:
413:
403:
397:
387:
376:
373:
372:
371:
368:Testadenovirus
364:
357:
353:Mastadenovirus
349:
346:Ichtadenovirus
342:
335:
319:
318:Classification
316:
314:
311:
235:
234:
233:
232:
229:Testadenovirus
225:
218:
215:Mastadenovirus
211:
208:Ichtadenovirus
204:
197:
187:
186:
182:
181:
174:
170:
169:
162:
158:
157:
150:
146:
145:
138:
134:
133:
126:
122:
121:
114:
107:
106:
101:
97:
96:
83:
82:
75:
74:
66:
65:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
9441:
9430:
9427:
9425:
9422:
9421:
9419:
9402:
9397:
9393:
9389:
9383:
9379:
9374:
9370:
9366:
9361:
9357:
9353:
9348:
9344:
9340:
9335:
9331:
9327:
9322:
9318:
9314:
9308:
9303:
9297:
9293:
9288:
9282:
9278:
9277:
9275:
9273:
9269:
9265:
9260:
9253:
9248:
9243:
9241:
9231:
9227:
9212:
9209:
9208:
9207:
9206:
9202:
9200:
9199:
9195:
9194:
9192:
9190:
9186:
9176:
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9170:
9168:
9166:
9162:
9155:
9151:
9150:
9146:
9143:
9139:
9138:
9134:
9131:
9127:
9126:
9122:
9119:
9115:
9114:
9110:
9108:
9107:
9103:
9101:
9098:
9097:
9093:
9089:
9088:
9084:
9082:
9079:
9078:
9076:
9074:
9070:
9064:
9063:
9059:
9057:
9056:
9052:
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9049:
9045:
9042:
9038:
9037:
9033:
9031:
9028:
9027:
9022:
9019:
9018:
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9016:
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9010:
9007:
9006:
9004:
9002:
8997:
8993:
8985:
8982:
8981:
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8958:
8956:
8952:
8948:
8945:
8943:
8937:
8927:
8926:
8922:
8920:
8919:
8915:
8911:
8910:Parainfluenza
8908:
8907:
8906:
8905:
8900:
8899:
8894:
8893:
8888:
8884:
8881:
8880:
8879:
8878:
8874:
8870:
8866:
8861:
8860:
8855:
8852:
8851:
8846:
8843:
8842:
8841:
8840:
8836:
8832:
8829:
8828:
8827:
8826:
8822:
8818:
8815:
8814:
8813:
8812:
8808:
8804:
8801:
8800:
8799:
8798:
8794:
8790:
8786:
8783:
8778:
8775:
8774:
8772:
8770:
8766:
8760:
8759:
8755:
8751:
8747:
8746:EBV infection
8744:
8743:
8742:
8741:
8737:
8736:
8734:
8732:
8728:
8725:
8723:
8718:
8711:
8707:
8699:
8696:
8694:
8691:
8690:
8689:
8688:
8684:
8683:
8681:
8679:
8675:
8663:
8660:
8659:
8658:
8657:
8653:
8649:
8646:
8645:
8644:
8643:
8639:
8638:
8636:
8634:
8630:
8622:
8619:
8618:
8617:
8616:
8612:
8608:
8605:
8603:
8602:Poliomyelitis
8600:
8599:
8598:
8597:
8593:
8592:
8590:
8588:
8584:
8578:
8575:
8573:
8570:
8568:
8565:
8561:
8558:
8557:
8556:
8555:
8551:
8547:
8544:
8543:
8541:
8540:
8536:
8534:
8531:
8527:
8524:
8523:
8522:
8521:
8517:
8513:
8510:
8509:
8508:
8507:
8503:
8501:
8498:
8497:
8492:
8489:
8488:
8487:
8486:
8482:
8480:
8477:
8476:
8474:
8472:
8467:
8463:
8460:
8458:
8452:
8444:
8441:
8440:
8439:
8438:
8434:
8433:
8431:
8429:
8425:
8417:
8414:
8413:
8412:
8411:
8407:
8403:
8400:
8398:
8395:
8394:
8393:
8392:
8388:
8386:
8383:
8382:
8377:
8374:
8373:
8372:
8371:
8367:
8363:
8360:
8358:
8355:
8353:
8350:
8348:
8345:
8343:
8340:
8339:
8338:
8337:
8333:
8329:
8326:
8325:
8324:
8323:
8319:
8315:
8312:
8310:
8307:
8305:
8304:Vulvar cancer
8302:
8300:
8299:Penile cancer
8297:
8295:
8292:
8290:
8287:
8286:
8285:
8284:
8280:
8276:
8273:
8272:
8271:
8270:
8266:
8264:
8261:
8260:
8258:
8256:
8252:
8248:
8244:
8237:
8232:
8230:
8225:
8223:
8218:
8217:
8214:
8174:
8173:
8169:
8168:
8166:
8164:
8163:
8158:
8152:
8151:
8147:
8146:
8144:
8142:
8141:
8140:Blubervirales
8136:
8133:
8131:
8130:
8125:
8122:
8120:
8119:
8114:
8111:
8109:
8108:
8103:
8100:
8098:
8097:
8092:
8088:
8084:
8078:
8074:
8044:
8043:
8039:
8037:
8036:
8035:Pseudoviridae
8032:
8030:
8029:
8025:
8023:
8022:
8021:Belpaoviridae
8018:
8017:
8015:
8013:
8012:
8007:
8004:
8002:
8001:
7996:
7993:
7991:
7990:
7985:
7982:
7980:
7979:
7974:
7971:
7969:
7968:
7963:
7959:
7955:
7949:
7945:
7942:
7940:
7936:
7902:
7901:
7897:
7896:
7894:
7892:
7891:
7886:
7883:
7881:
7880:
7875:
7865:
7864:
7860:
7858:
7857:
7853:
7851:
7850:
7849:Rhabdoviridae
7846:
7844:
7843:
7842:Pneumoviridae
7839:
7837:
7836:
7832:
7830:
7829:
7825:
7823:
7822:
7821:Mymonaviridae
7818:
7816:
7815:
7811:
7809:
7808:
7804:
7802:
7801:
7797:
7795:
7794:
7790:
7789:
7787:
7785:
7784:
7779:
7773:
7772:
7771:Natareviridae
7768:
7766:
7765:
7761:
7759:
7758:
7754:
7752:
7751:
7747:
7745:
7744:
7740:
7739:
7737:
7735:
7734:
7729:
7726:
7724:
7723:
7718:
7708:
7707:
7703:
7702:
7700:
7698:
7697:
7692:
7689:
7687:
7686:
7681:
7671:
7670:
7666:
7664:
7663:
7662:Amnoonviridae
7659:
7658:
7656:
7654:
7653:
7648:
7645:
7643:
7642:
7637:
7627:
7626:
7625:Wupedeviridae
7622:
7620:
7619:
7615:
7613:
7612:
7611:Phenuiviridae
7608:
7606:
7605:
7604:Phasmaviridae
7601:
7599:
7598:
7594:
7592:
7591:
7587:
7585:
7584:
7580:
7578:
7577:
7573:
7571:
7570:
7566:
7564:
7563:
7559:
7557:
7556:
7552:
7550:
7549:
7545:
7544:
7542:
7540:
7539:
7534:
7531:
7529:
7528:
7523:
7513:
7512:
7508:
7507:
7505:
7503:
7502:
7497:
7494:
7492:
7491:
7486:
7483:
7481:
7480:
7475:
7472:
7470:
7469:
7468:Orthornavirae
7464:
7461:
7459:
7458:
7453:
7449:
7445:
7439:
7435:
7413:
7412:
7408:
7406:
7405:
7400:
7397:
7396:
7394:
7390:
7376:
7375:
7371:
7370:
7368:
7366:
7365:
7364:Stellavirales
7360:
7354:
7353:
7349:
7348:
7346:
7344:
7343:
7342:Patatavirales
7338:
7335:
7333:
7332:
7327:
7317:
7316:
7315:Solemoviridae
7312:
7310:
7309:
7305:
7303:
7302:
7298:
7297:
7295:
7293:
7292:
7291:Sobelivirales
7287:
7281:
7280:
7276:
7274:
7273:
7269:
7267:
7266:
7262:
7260:
7259:
7255:
7253:
7252:
7251:Caliciviridae
7248:
7246:
7245:
7241:
7239:
7238:
7234:
7232:
7231:
7227:
7226:
7224:
7222:
7221:
7216:
7210:
7209:
7208:Tobaniviridae
7205:
7203:
7202:
7198:
7196:
7195:
7191:
7189:
7188:
7184:
7182:
7181:
7177:
7175:
7174:
7173:Mononiviridae
7170:
7168:
7167:
7166:Mesoniviridae
7163:
7161:
7160:
7156:
7154:
7153:
7152:Gresnaviridae
7149:
7147:
7146:
7145:Euroniviridae
7142:
7140:
7139:
7138:Coronaviridae
7135:
7133:
7132:
7128:
7126:
7125:
7124:Arteriviridae
7121:
7119:
7118:
7117:Abyssoviridae
7114:
7113:
7111:
7109:
7108:
7103:
7100:
7098:
7097:
7092:
7089:
7087:
7086:
7081:
7067:
7066:
7062:
7061:
7059:
7057:
7056:
7051:
7048:
7046:
7045:
7040:
7030:
7029:
7025:
7024:
7022:
7020:
7019:
7018:Cryppavirales
7014:
7011:
7009:
7008:
7003:
6993:
6992:
6988:
6987:
6985:
6983:
6982:
6977:
6974:
6972:
6971:
6966:
6956:
6955:
6954:Steitzviridae
6951:
6949:
6948:
6944:
6943:
6941:
6939:
6938:
6933:
6927:
6926:
6925:Solspiviridae
6922:
6920:
6919:
6915:
6913:
6912:
6908:
6906:
6905:
6904:Atkinsviridae
6901:
6900:
6898:
6896:
6895:
6890:
6887:
6885:
6884:
6883:Leviviricetes
6879:
6876:
6874:
6873:
6872:Lenarviricota
6868:
6854:
6853:
6852:Tombusviridae
6849:
6847:
6846:
6842:
6840:
6839:
6835:
6834:
6832:
6830:
6829:
6824:
6821:
6819:
6818:
6813:
6803:
6802:
6798:
6796:
6795:
6791:
6790:
6788:
6786:
6785:
6784:Nodamuvirales
6780:
6777:
6775:
6774:
6769:
6759:
6758:
6754:
6753:
6751:
6749:
6748:
6743:
6740:
6738:
6737:
6732:
6722:
6721:
6717:
6715:
6714:
6710:
6708:
6707:
6703:
6701:
6700:
6696:
6694:
6693:
6689:
6688:
6686:
6684:
6683:
6678:
6672:
6671:
6667:
6665:
6664:
6660:
6658:
6657:
6653:
6651:
6650:
6646:
6644:
6643:
6639:
6637:
6636:
6632:
6630:
6629:
6625:
6624:
6622:
6620:
6619:
6614:
6608:
6607:
6606:Matonaviridae
6603:
6601:
6600:
6596:
6594:
6593:
6589:
6587:
6586:
6582:
6581:
6579:
6577:
6576:
6575:Hepelivirales
6571:
6568:
6566:
6565:
6564:Alsuviricetes
6560:
6557:
6555:
6554:
6549:
6546:
6544:
6543:
6542:Orthornavirae
6538:
6535:
6533:
6532:
6527:
6523:
6519:
6513:
6509:
6487:
6486:
6481:
6478:
6476:
6475:
6471:
6469:
6468:
6463:
6460:
6459:
6457:
6453:
6439:
6438:
6434:
6432:
6431:
6427:
6425:
6424:
6420:
6418:
6417:
6413:
6411:
6410:
6409:Amalgaviridae
6406:
6405:
6403:
6401:
6400:
6395:
6392:
6390:
6389:
6384:
6381:
6379:
6378:
6373:
6359:
6358:
6354:
6353:
6351:
6349:
6348:
6343:
6340:
6338:
6337:
6332:
6322:
6321:
6317:
6316:
6314:
6312:
6311:
6306:
6303:
6301:
6300:
6295:
6285:
6284:
6280:
6278:
6277:
6276:Quadriviridae
6273:
6271:
6270:
6266:
6264:
6263:
6262:Chrysoviridae
6259:
6258:
6256:
6254:
6253:
6252:Ghabrivirales
6248:
6245:
6243:
6242:
6237:
6234:
6232:
6231:
6226:
6223:
6221:
6220:
6219:Orthornavirae
6215:
6212:
6210:
6209:
6204:
6200:
6196:
6195:dsRNA viruses
6190:
6186:
6183:
6181:
6177:
6159:
6158:
6154:
6152:
6151:
6147:
6145:
6144:
6143:Anelloviridae
6139:
6136:
6135:
6133:
6129:
6107:
6106:
6102:
6101:
6099:
6097:
6096:
6095:Haloruvirales
6091:
6088:
6086:
6085:
6080:
6077:
6075:
6074:
6069:
6066:
6064:
6063:
6058:
6040:
6039:
6038:Genomoviridae
6035:
6033:
6032:
6031:Geminiviridae
6028:
6027:
6025:
6023:
6022:
6017:
6014:
6012:
6011:
6006:
5996:
5995:
5991:
5990:
5988:
5986:
5985:
5980:
5974:
5973:
5969:
5967:
5966:
5965:Metaxyviridae
5962:
5961:
5959:
5957:
5956:
5951:
5945:
5944:
5940:
5939:
5937:
5935:
5934:
5929:
5923:
5922:
5918:
5917:
5915:
5913:
5912:
5907:
5901:
5900:
5896:
5895:
5893:
5891:
5890:
5885:
5882:
5880:
5879:
5878:Arfiviricetes
5874:
5871:
5869:
5868:
5863:
5849:
5848:
5844:
5843:
5841:
5839:
5838:
5833:
5830:
5828:
5827:
5822:
5812:
5811:
5807:
5806:
5804:
5802:
5801:
5796:
5793:
5791:
5790:
5785:
5782:
5780:
5779:
5778:Cossaviricota
5774:
5771:
5769:
5768:
5763:
5745:
5744:
5740:
5739:
5737:
5735:
5734:
5729:
5726:
5724:
5723:
5718:
5715:
5713:
5712:
5707:
5704:
5702:
5701:
5696:
5678:
5677:
5673:
5671:
5670:
5666:
5664:
5663:
5659:
5658:
5656:
5654:
5653:
5652:Tubulavirales
5648:
5645:
5643:
5642:
5637:
5634:
5632:
5631:
5626:
5623:
5621:
5620:
5615:
5612:
5610:
5609:
5604:
5600:
5596:
5595:ssDNA viruses
5590:
5586:
5568:
5567:
5566:Rhizidiovirus
5563:
5561:
5560:
5555:
5552:
5550:
5549:
5548:Thaspiviridae
5545:
5543:
5542:
5538:
5536:
5535:
5531:
5529:
5528:
5527:Plasmaviridae
5524:
5522:
5521:
5517:
5515:
5514:
5513:Halspiviridae
5510:
5508:
5507:
5503:
5501:
5500:
5496:
5494:
5493:
5489:
5487:
5486:
5482:
5480:
5479:
5475:
5473:
5472:
5467:
5464:
5463:
5461:
5457:
5447:
5446:
5442:
5441:
5439:
5435:
5429:
5428:
5424:
5422:
5421:
5417:
5415:
5414:
5413:Baculoviridae
5410:
5409:
5407:
5405:
5404:
5399:
5396:
5394:
5393:
5388:
5385:
5381:
5359:
5358:
5354:
5352:
5351:
5350:Simuloviridae
5347:
5345:
5344:
5340:
5339:
5337:
5335:
5334:
5329:
5326:
5324:
5323:
5318:
5315:
5313:
5312:
5307:
5304:
5302:
5301:
5300:Helvetiavirae
5296:
5278:
5277:
5273:
5272:
5270:
5268:
5267:
5262:
5256:
5255:
5251:
5250:
5248:
5246:
5245:
5240:
5234:
5233:
5229:
5228:
5226:
5224:
5223:
5222:Kalamavirales
5218:
5212:
5211:
5207:
5206:
5204:
5202:
5201:
5200:Belfryvirales
5196:
5193:
5191:
5190:
5185:
5175:
5174:
5173:Adintoviridae
5170:
5169:
5167:
5165:
5164:
5159:
5156:
5154:
5153:
5148:
5138:
5137:
5136:Lavidaviridae
5133:
5132:
5130:
5128:
5127:
5122:
5119:
5117:
5116:
5111:
5108:
5106:
5105:
5100:
5086:
5085:
5081:
5079:
5078:
5074:
5072:
5071:
5067:
5066:
5064:
5062:
5061:
5056:
5050:
5049:
5045:
5044:
5042:
5040:
5039:
5038:Imitervirales
5034:
5028:
5027:
5023:
5022:
5020:
5018:
5017:
5012:
5009:
5007:
5006:
5005:Megaviricetes
5001:
4991:
4990:
4986:
4985:
4983:
4981:
4980:
4975:
4969:
4968:
4964:
4963:
4961:
4959:
4958:
4953:
4950:
4948:
4947:
4942:
4939:
4937:
4936:
4931:
4928:
4926:
4925:
4920:
4917:
4915:
4914:
4909:
4887:
4886:
4882:
4881:
4879:
4877:
4876:
4871:
4865:
4864:
4860:
4859:
4857:
4855:
4854:
4853:Sepolyvirales
4849:
4846:
4844:
4843:
4838:
4835:
4833:
4832:
4831:Cossaviricota
4827:
4824:
4822:
4821:
4816:
4813:
4811:
4810:
4805:
4783:
4782:
4781:Zobellviridae
4778:
4776:
4775:
4771:
4769:
4768:
4767:Schitoviridae
4764:
4762:
4761:
4757:
4755:
4754:
4750:
4748:
4747:
4743:
4741:
4740:
4736:
4734:
4733:
4729:
4727:
4726:
4725:Guelinviridae
4722:
4720:
4719:
4715:
4713:
4712:
4708:
4706:
4705:
4701:
4699:
4698:
4694:
4692:
4691:
4687:
4686:
4684:
4682:
4681:
4676:
4673:
4671:
4670:
4665:
4662:
4660:
4659:
4654:
4640:
4639:
4635:
4633:
4632:
4631:Herpesviridae
4628:
4626:
4625:
4621:
4620:
4618:
4616:
4615:
4614:Herpesvirales
4610:
4607:
4605:
4604:
4599:
4596:
4594:
4593:
4592:Peploviricota
4588:
4585:
4583:
4582:
4577:
4574:
4572:
4571:
4570:Duplodnaviria
4566:
4544:
4543:
4539:
4538:
4536:
4534:
4533:
4528:
4522:
4521:
4517:
4515:
4514:
4510:
4509:
4507:
4505:
4504:
4499:
4496:
4494:
4493:
4492:Tokiviricetes
4488:
4485:
4483:
4482:
4481:Taleaviricota
4477:
4474:
4472:
4471:
4466:
4463:
4461:
4460:
4455:
4451:
4447:
4446:dsDNA viruses
4441:
4437:
4434:
4432:
4428:
4423:
4419:
4412:
4407:
4405:
4400:
4398:
4393:
4392:
4389:
4377:
4374:
4373:
4371:
4367:
4361:
4358:
4356:
4353:
4351:
4348:
4346:
4343:
4341:
4338:
4336:
4333:
4331:
4330:Bronchiolitis
4328:
4326:
4323:
4322:
4320:
4318:
4317:Complications
4314:
4308:
4305:
4303:
4300:
4298:
4295:
4293:
4290:
4288:
4285:
4283:
4280:
4278:
4275:
4273:
4270:
4268:
4265:
4263:
4260:
4258:
4255:
4253:
4250:
4249:
4247:
4245:
4241:
4235:
4232:
4230:
4227:
4225:
4222:
4220:
4217:
4216:
4214:
4212:
4208:
4204:
4197:
4192:
4190:
4185:
4183:
4178:
4177:
4174:
4167:
4158:
4154:
4149:
4144:
4140:
4136:
4131:
4126:
4122:
4118:
4114:
4107:
4104:
4099:
4095:
4090:
4085:
4081:
4077:
4072:
4067:
4063:
4059:
4055:
4051:
4047:
4040:
4037:
4032:
4025:
4022:
4017:
4013:
4008:
4003:
3999:
3995:
3991:
3987:
3983:
3976:
3973:
3960:
3953:
3950:
3945:
3941:
3936:
3931:
3927:
3923:
3919:
3915:
3911:
3907:
3903:
3896:
3893:
3880:
3873:
3870:
3865:
3861:
3856:
3851:
3847:
3843:
3839:
3835:
3831:
3827:
3820:
3817:
3812:
3808:
3803:
3798:
3794:
3790:
3786:
3782:
3778:
3771:
3768:
3763:
3759:
3754:
3749:
3745:
3741:
3737:
3733:
3729:
3722:
3719:
3706:
3702:
3696:
3693:
3688:
3684:
3679:
3674:
3670:
3666:
3662:
3658:
3654:
3647:
3645:
3641:
3628:
3624:
3618:
3616:
3612:
3601:
3597:
3591:
3588:
3583:
3579:
3574:
3569:
3565:
3561:
3557:
3553:
3549:
3542:
3539:
3526:
3519:
3517:
3513:
3500:
3496:
3492:
3485:
3482:
3477:
3473:
3469:
3463:
3459:
3458:
3450:
3447:
3442:
3438:
3434:
3430:
3426:
3422:
3415:
3412:
3407:
3403:
3399:
3395:
3391:
3387:
3379:
3376:
3371:
3365:
3361:
3356:
3355:
3346:
3343:
3338:
3334:
3329:
3324:
3320:
3316:
3312:
3308:
3304:
3297:
3294:
3289:
3285:
3278:
3275:
3270:
3266:
3262:
3258:
3254:
3250:
3246:
3242:
3234:
3231:
3220:
3219:
3214:
3207:
3204:
3199:
3195:
3191:
3187:
3184:(3): 627–42.
3183:
3179:
3172:
3169:
3156:
3152:
3146:
3143:
3139:. 2019-08-29.
3138:
3132:
3129:
3124:
3120:
3114:
3111:
3106:
3100:
3097:
3093:. 2019-09-03.
3092:
3086:
3084:
3080:
3075:
3071:
3066:
3061:
3056:
3051:
3047:
3043:
3039:
3032:
3029:
3024:
3020:
3015:
3010:
3006:
3002:
2998:
2991:
2988:
2983:
2979:
2973:
2970:
2965:
2961:
2956:
2951:
2947:
2943:
2939:
2932:
2929:
2924:
2918:
2914:
2907:
2905:
2901:
2896:
2892:
2887:
2882:
2878:
2874:
2870:
2866:
2862:
2855:
2852:
2847:
2843:
2839:
2835:
2828:
2825:
2820:
2816:
2811:
2806:
2801:
2796:
2792:
2788:
2784:
2780:
2776:
2769:
2766:
2761:
2757:
2752:
2747:
2743:
2739:
2735:
2731:
2727:
2720:
2717:
2712:
2708:
2704:
2700:
2696:
2692:
2689:(3): 267–85.
2688:
2684:
2677:
2674:
2669:
2665:
2661:
2657:
2654:(2): 529–31.
2653:
2649:
2642:
2640:
2636:
2631:
2627:
2622:
2617:
2612:
2607:
2603:
2599:
2595:
2588:
2585:
2580:
2576:
2571:
2566:
2562:
2558:
2554:
2550:
2546:
2539:
2537:
2535:
2531:
2526:
2522:
2517:
2512:
2508:
2504:
2500:
2496:
2492:
2485:
2482:
2477:
2473:
2469:
2465:
2460:
2455:
2451:
2447:
2443:
2436:
2433:
2428:
2424:
2419:
2414:
2410:
2406:
2402:
2398:
2394:
2387:
2384:
2379:
2373:
2369:
2365:
2361:
2354:
2351:
2346:
2342:
2338:
2334:
2330:
2326:
2319:
2316:
2311:
2305:
2301:
2294:
2291:
2286:
2282:
2278:
2274:
2270:
2266:
2262:
2258:
2254:
2250:
2243:
2240:
2233:
2232:Science Daily
2229:
2224:
2223:
2220:
2216:
2211:
2206:
2202:
2198:
2194:
2190:
2186:
2182:
2178:
2171:
2168:
2156:
2150:
2146:
2142:
2135:
2132:
2127:
2123:
2119:
2115:
2111:
2107:
2104:(6): 379–87.
2103:
2099:
2095:
2088:
2085:
2072:
2068:
2062:
2059:
2054:
2050:
2045:
2040:
2036:
2032:
2028:
2024:
2020:
2013:
2010:
2005:
2001:
1996:
1991:
1987:
1983:
1979:
1975:
1971:
1964:
1961:
1956:
1952:
1947:
1942:
1938:
1934:
1930:
1926:
1922:
1915:
1912:
1907:
1903:
1898:
1893:
1889:
1885:
1882:(8): 4693–5.
1881:
1877:
1873:
1866:
1863:
1858:
1854:
1849:
1844:
1840:
1836:
1832:
1828:
1824:
1817:
1814:
1809:
1805:
1800:
1795:
1791:
1787:
1783:
1779:
1775:
1768:
1765:
1760:
1756:
1751:
1746:
1741:
1736:
1732:
1728:
1724:
1720:
1716:
1709:
1706:
1693:
1687:
1684:
1679:
1675:
1671:
1667:
1663:
1659:
1655:
1651:
1647:
1643:
1637:
1634:
1621:
1617:
1611:
1609:
1607:
1605:
1603:
1601:
1599:
1597:
1595:
1593:
1591:
1589:
1587:
1583:
1573:
1569:
1565:
1564:
1556:
1553:
1546:
1542:
1539:
1538:
1534:
1528:
1523:
1520:
1509:
1504:
1502:
1499:
1495:
1491:
1487:
1483:
1479:
1478:Ebola vaccine
1475:
1471:
1470:
1464:
1462:
1458:
1454:
1451:
1447:
1443:
1439:
1435:
1434:
1429:
1412:
1408:
1397:
1394:
1390:
1387:
1383:
1380:
1376:
1373:
1369:
1366: –
1365:
1361:
1360:Find sources:
1355:
1351:
1345:
1344:
1340:
1336:
1331:This section
1329:
1320:
1319:
1313:
1311:
1307:
1305:
1301:
1297:
1296:Gam-COVID-Vac
1293:
1289:
1285:
1281:
1277:
1273:
1269:
1266:
1261:
1259:
1255:
1249:
1241:
1239:
1237:
1234:
1229:
1227:
1223:
1218:
1216:
1212:
1208:
1204:
1200:
1196:
1192:
1188:
1184:
1180:
1176:
1172:
1168:
1160:
1155:
1153:
1150:
1146:
1145:acetaminophen
1138:
1136:
1134:
1129:
1125:
1122:
1117:
1115:
1111:
1107:
1103:
1099:
1095:
1091:
1090:bronchiolitis
1086:
1084:
1080:
1076:
1075:ear infection
1072:
1068:
1064:
1058:
1050:
1048:
1041:
1039:
1035:
1031:
1026:
1018:
1016:
1014:
1010:
1008:
1004:
1000:
996:
992:
988:
983:
981:
977:
972:
970:
966:
962:
958:
957:Arabian foals
954:
950:
946:
942:
938:
934:
929:
927:
923:
919:
917:
914:
910:
906:
902:
898:
894:
890:
889:Vulpes vulpes
886:
882:
878:
874:
871:Two types of
869:
867:
863:
862:
857:
856:
851:
847:
842:
834:
832:
830:
824:
816:
814:
812:
808:
804:
800:
796:
788:
783:
781:
774:
772:
770:
764:
762:
758:
752:
750:
746:
742:
738:
734:
729:
727:
723:
719:
715:
711:
710:DNA synthesis
707:
702:
700:
696:
692:
688:
684:
680:
676:
671:
668:
664:
660:
656:
652:
646:
644:
640:
636:
632:
628:
624:
620:
616:
612:
608:
604:
600:
595:
591:
587:
583:
575:
573:
571:
567:
563:
559:
550:
545:
537:
535:
533:
529:
524:
522:
519:
515:
511:
507:
503:
499:
491:
486:
479:
477:
475:
474:
469:
461:
458:
455:
452:
449:
446:
443:
440:
439:
438:
432:
429:
427:
423:
420:
417:
414:
411:
407:
404:
401:
398:
395:
391:
388:
385:
382:
381:
380:
374:
370:
369:
365:
363:
362:
358:
355:
354:
350:
348:
347:
343:
341:
340:
339:Aviadenovirus
336:
334:
333:
329:
328:
327:
325:
317:
312:
310:
308:
304:
300:
296:
292:
287:
285:
281:
278:containing a
277:
274:
270:
266:
262:
258:
257:
253:
249:
241:
231:
230:
226:
224:
223:
219:
217:
216:
212:
210:
209:
205:
203:
202:
201:Aviadenovirus
198:
196:
195:
191:
190:
188:
183:
180:
179:
175:
172:
171:
168:
167:
163:
160:
159:
156:
155:
151:
148:
147:
144:
143:
139:
136:
135:
132:
131:
127:
124:
123:
120:
119:
115:
112:
109:
108:
105:
102:
99:
98:
93:
88:
84:
80:
76:
72:
67:
64:Adenoviruses
62:
57:
53:
49:
45:
41:
37:
33:
19:
9424:Adenoviridae
9302:Adenoviridae
9272:Adenoviridae
9271:
9203:
9196:
9172:
9165:Pancreatitis
9147:
9135:
9123:
9111:
9104:
9085:
9060:
9053:
9046:
9034:
9014:
9013:
8976:
8962:
8923:
8916:
8902:
8896:
8863:
8857:
8837:
8823:
8809:
8780:
8756:
8738:
8693:Pericarditis
8685:
8654:
8640:
8613:
8594:
8552:
8537:
8518:
8504:
8483:
8466:Encephalitis
8435:
8408:
8389:
8368:
8334:
8320:
8281:
8267:
8170:
8162:Ortervirales
8160:
8148:
8138:
8127:
8116:
8107:Pararnavirae
8105:
8094:
8042:Retroviridae
8040:
8033:
8026:
8019:
8011:Ortervirales
8009:
7998:
7987:
7978:Pararnavirae
7976:
7965:
7898:
7888:
7877:
7863:Xinmoviridae
7861:
7854:
7847:
7840:
7833:
7828:Nyamiviridae
7826:
7819:
7814:Lispiviridae
7812:
7805:
7800:Bornaviridae
7798:
7791:
7781:
7769:
7764:Myriaviridae
7762:
7755:
7748:
7743:Aliusviridae
7741:
7731:
7720:
7704:
7694:
7683:
7667:
7660:
7650:
7639:
7623:
7618:Tospoviridae
7616:
7609:
7602:
7595:
7590:Nairoviridae
7588:
7581:
7574:
7569:Hantaviridae
7567:
7560:
7555:Arenaviridae
7553:
7548:Cruliviridae
7546:
7538:Bunyavirales
7536:
7525:
7509:
7499:
7488:
7477:
7466:
7455:
7409:
7402:
7398:
7374:Astroviridae
7372:
7362:
7350:
7340:
7329:
7313:
7308:Barnaviridae
7306:
7299:
7289:
7277:
7270:
7263:
7256:
7249:
7242:
7237:Marnaviridae
7235:
7228:
7218:
7206:
7199:
7194:Olifoviridae
7192:
7185:
7178:
7171:
7164:
7157:
7150:
7143:
7136:
7129:
7122:
7115:
7105:
7094:
7085:Pisuviricota
7083:
7063:
7055:Ourlivirales
7053:
7044:Miaviricetes
7042:
7026:
7016:
7005:
6991:Narnaviridae
6989:
6979:
6968:
6952:
6947:Blumeviridae
6945:
6937:Timlovirales
6935:
6923:
6918:Fiersviridae
6916:
6909:
6902:
6894:Norzivirales
6892:
6881:
6870:
6850:
6845:Luteoviridae
6843:
6836:
6826:
6815:
6799:
6792:
6782:
6771:
6757:Flaviviridae
6755:
6745:
6734:
6718:
6711:
6704:
6697:
6690:
6680:
6670:Virgaviridae
6668:
6661:
6654:
6647:
6640:
6633:
6628:Bromoviridae
6626:
6616:
6604:
6597:
6590:
6583:
6573:
6562:
6551:
6540:
6529:
6483:
6479:
6472:
6467:Birnaviridae
6465:
6461:
6435:
6428:
6421:
6414:
6407:
6399:Durnavirales
6397:
6386:
6377:Pisuviricota
6375:
6357:Cystoviridae
6355:
6347:Mindivirales
6345:
6334:
6318:
6308:
6297:
6281:
6274:
6267:
6260:
6250:
6239:
6228:
6217:
6206:
6157:Spiraviridae
6155:
6148:
6141:
6137:
6103:
6093:
6082:
6073:Saleviricota
6071:
6060:
6036:
6029:
6019:
6008:
5992:
5984:Recrevirales
5982:
5970:
5963:
5955:Mulpavirales
5953:
5943:Smacoviridae
5941:
5933:Cremevirales
5931:
5921:Circoviridae
5919:
5911:Cirlivirales
5909:
5897:
5889:Baphyvirales
5887:
5876:
5865:
5847:Parvoviridae
5845:
5837:Piccovirales
5835:
5824:
5810:Bidnaviridae
5808:
5798:
5789:Mouviricetes
5787:
5776:
5767:Shotokuvirae
5765:
5743:Microviridae
5741:
5733:Petitvirales
5731:
5720:
5711:Phixviricota
5709:
5698:
5674:
5667:
5660:
5650:
5639:
5628:
5617:
5608:Monodnaviria
5606:
5564:
5559:Dinodnavirus
5557:
5553:
5546:
5539:
5532:
5525:
5520:Ovaliviridae
5518:
5511:
5506:Guttaviridae
5504:
5497:
5490:
5485:Clavaviridae
5483:
5476:
5469:
5465:
5443:
5425:
5418:
5411:
5401:
5390:
5355:
5348:
5341:
5331:
5320:
5309:
5298:
5274:
5264:
5254:Adenoviridae
5253:
5252:
5242:
5232:Tectiviridae
5230:
5220:
5210:Turriviridae
5208:
5198:
5187:
5171:
5161:
5150:
5134:
5124:
5113:
5102:
5082:
5077:Iridoviridae
5075:
5068:
5058:
5046:
5036:
5024:
5014:
5003:
4987:
4979:Chitovirales
4977:
4967:Asfarviridae
4965:
4955:
4944:
4933:
4924:Bamfordvirae
4922:
4913:Varidnaviria
4911:
4883:
4873:
4861:
4851:
4840:
4829:
4820:Shotokuvirae
4818:
4809:Monodnaviria
4807:
4779:
4774:Siphoviridae
4772:
4765:
4758:
4751:
4744:
4737:
4730:
4723:
4716:
4709:
4704:Chaseviridae
4702:
4695:
4688:
4680:Caudovirales
4678:
4667:
4656:
4636:
4629:
4622:
4612:
4601:
4590:
4579:
4568:
4540:
4532:Primavirales
4530:
4518:
4511:
4501:
4490:
4479:
4468:
4457:
4360:Strep throat
4340:Otitis media
4282:Muscle aches
4218:
4120:
4116:
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4039:
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3975:
3963:. Retrieved
3952:
3909:
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3895:
3883:. Retrieved
3881:. HIV i-BASE
3872:
3837:
3833:
3819:
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3780:
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3735:
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3709:. Retrieved
3704:
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3503:. Retrieved
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3233:
3222:. Retrieved
3216:
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3159:. Retrieved
3154:
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3123:the original
3113:
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3045:
3041:
3031:
3007:(1): 272–6.
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3000:
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2981:
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2144:
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2087:
2075:. Retrieved
2070:
2061:
2026:
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1977:
1973:
1963:
1928:
1924:
1914:
1879:
1875:
1865:
1833:(2): 141–7.
1830:
1826:
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1767:
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1708:
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1686:
1656:(3): 570–3.
1653:
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1636:
1624:. Retrieved
1619:
1575:, retrieved
1562:
1555:
1489:
1482:Sierra Leone
1467:
1465:
1431:
1424:
1402:
1392:
1385:
1378:
1371:
1359:
1339:verification
1332:
1308:
1299:
1265:viral vector
1262:
1251:
1236:gene editing
1230:
1219:
1171:gene therapy
1167:viral vector
1164:
1161:Gene therapy
1142:
1130:
1126:
1118:
1106:encephalitis
1087:
1071:strep throat
1060:
1045:
1036:
1032:
1028:
1011:
1002:
998:
994:
990:
986:
984:
979:
973:
968:
952:
930:
924:
920:
901:kennel cough
896:
892:
888:
870:
859:
853:
849:
844:
826:
792:
789:Transmission
784:Epidemiology
778:
765:
753:
740:
730:
703:
689:to generate
672:
663:nuclear pore
655:microtubules
647:
579:
555:
525:
495:
471:
465:
436:
392:: 3, 7, 11,
386:: 12, 18, 31
378:
366:
361:Siadenovirus
359:
351:
344:
337:
332:Atadenovirus
330:
321:
288:
276:nucleocapsid
265:nonenveloped
256:Adenoviridae
255:
254:
248:Adenoviruses
247:
246:
227:
222:Siadenovirus
220:
213:
206:
199:
194:Atadenovirus
192:
178:Adenoviridae
177:
176:
165:
164:
153:
141:
130:Bamfordvirae
129:
118:Varidnaviria
117:
110:
100:(unranked):
9296:Wikispecies
9062:Coronavirus
8803:Common cold
8715:acute viral
8698:Myocarditis
8542:(probable)
8294:Anal cancer
8028:Metaviridae
7807:Filoviridae
7793:Artoviridae
7706:Aspiviridae
7583:Mypoviridae
7562:Fimoviridae
7352:Potyviridae
7265:Secoviridae
7258:Iflaviridae
7201:Roniviridae
7107:Nidovirales
7028:Mitoviridae
6911:Duinviridae
6828:Tolivirales
6794:Nodaviridae
6720:Tymoviridae
6682:Tymovirales
6663:Togaviridae
6656:Mayoviridae
6649:Kitaviridae
6599:Hepeviridae
6592:Benyviridae
6423:Hypoviridae
6283:Totiviridae
5972:Nanoviridae
5800:Polivirales
5700:Sangervirae
5445:Nimaviridae
5427:Nudiviridae
5403:Lefavirales
5266:Vinavirales
5244:Rowavirales
5070:Ascoviridae
5048:Mimiviridae
5016:Algavirales
4957:Asfuvirales
4746:Podoviridae
4658:Uroviricota
4520:Rudiviridae
4470:Zilligvirae
4345:Pharyngitis
4302:Sore throat
4229:Enterovirus
4224:Coronavirus
4203:Common cold
3965:15 December
3885:15 December
3826:Kobinger GP
3633:22 December
3600:www.who.int
3531:15 December
3505:15 December
2071:www.cdc.gov
1725:(1): 1039.
1333:needs more
1292:UQ-CSL V451
1254:recombinant
1233:CRISPR/Cas9
1193:, X-linked
1067:tonsillitis
1013:Titi monkey
1007:black kites
726:MHC class I
631:endocytosis
627:αV integrin
615:sialic acid
576:Replication
303:common cold
273:icosahedral
166:Rowavirales
9418:Categories
9189:Urogenital
9055:Astrovirus
9015:Adenovirus
8839:SARS-CoV-2
8596:Poliovirus
8471:meningitis
7900:Yueviridae
7856:Sunviridae
7750:Chuviridae
7511:Qinviridae
7392:Unassigned
6455:Unassigned
6320:Reoviridae
6310:Reovirales
6131:Unassigned
6062:Trapavirae
5662:Inoviridae
5459:Unassigned
5437:Unassigned
5383:Unassigned
4989:Poxviridae
4739:Myoviridae
4292:Rhinorrhea
4234:Rhinovirus
4219:Adenovirus
3605:2021-03-07
3476:1163431307
3224:2007-12-19
2604:(2): 143.
1646:Huebner RJ
1577:2021-07-24
1547:References
1490:The Lancet
1486:prevalence
1442:Convidecia
1433:The Lancet
1405:April 2021
1375:newspapers
1276:SARS-CoV-2
1252:Modified (
1175:transgenes
1051:Infections
1019:Prevention
961:pancreatic
881:vasculitis
866:tree shrew
839:See also:
722:interferon
699:translated
675:life cycle
594:vertebrate
528:amino acid
514:attachment
291:vertebrate
18:Adenoviral
9100:RNA virus
9081:DNA virus
9073:Hepatitis
9048:Norovirus
9036:Rotavirus
9030:RNA virus
9009:DNA virus
8955:Esophagus
8883:Influenza
8769:RNA virus
8731:DNA virus
8500:RNA virus
8479:DNA virus
8385:RNA virus
8263:DNA virus
8255:Oncovirus
8096:Riboviria
7967:Riboviria
7501:Muvirales
7457:Riboviria
6531:Riboviria
6208:Riboviria
5619:Loebvirae
4459:Adnaviria
4418:Baltimore
4355:Sinusitis
4350:Pneumonia
4139:1553-7374
4080:0027-8424
3926:0036-8075
3711:28 August
2285:206528739
2077:6 January
1931:: 452–9.
1626:6 January
1461:Canarypox
1438:Sputnik V
1187:monogenic
1149:cidofovir
1139:Treatment
1094:pneumonia
1042:Diagnosis
976:sea lions
885:hepatitis
718:apoptosis
619:capsomere
586:replicate
480:Structure
375:Diversity
299:illnesses
295:serotypes
286:in 1953.
125:Kingdom:
9310:BioLib:
9281:Wikidata
9240:Medicine
9198:BK virus
9001:diarrhea
8845:COVID-19
8587:Myelitis
7399:Families
6462:Families
6138:Families
5466:Families
4307:Weakness
4297:Sneezing
4267:Headache
4244:Symptoms
4157:29474461
4098:25197078
4016:33091364
3944:24700849
3864:25483662
3828:(2014).
3811:32896291
3762:32931734
3705:Sci News
3687:32450106
3582:32702298
3441:19766576
3406:17386962
3337:19786146
3288:NBC News
3269:49870344
3261:30022238
3074:21779173
3023:20090043
2964:21790072
2895:20089640
2846:22978165
2819:11095726
2760:34446582
2711:18295550
2648:Virology
2630:30744049
2579:28944281
2525:37641864
2516:10548178
2476:22241820
2468:14978758
2427:21209115
2345:15051066
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2219:20798318
2160:12 March
2118:26352001
2053:17360747
2004:32773498
1955:26343864
1925:Virology
1906:22301156
1857:21056888
1827:Virology
1808:21849694
1759:30705303
1670:13134217
1505:See also
1288:Ad5-nCoV
1258:antigens
1242:Vaccines
967:tissue.
905:vaccines
795:chemical
741:in vitro
706:proteins
695:ribosome
685:that is
661:via the
643:endosome
623:integrin
516:to the
313:Virology
284:adenoids
271:with an
173:Family:
137:Phylum:
9388:1883639
9287:Q193447
9252:Viruses
9226:Portals
8951:Pharynx
8455:Central
4277:Malaise
4257:Fatigue
4211:Viruses
4148:5841825
4089:4169982
4058:Bibcode
4007:7571904
3935:4414116
3906:Science
3855:5443060
3802:7471804
3753:7437481
3678:7255193
3573:7445431
3421:Vaccine
3386:Vaccine
3328:2784276
3307:Vaccine
3198:1962727
3161:11 July
3151:"Croup"
3065:3136464
2886:2849498
2787:Bibcode
2751:8721651
2730:Science
2691:Bibcode
2668:4328814
2621:6409611
2598:Viruses
2570:5609467
2418:3067937
2257:Bibcode
2249:Science
2210:2929978
2189:Bibcode
2181:Science
2126:5370331
2044:1900323
1995:8286627
1946:4619159
1897:3318657
1848:3006489
1799:3187342
1750:6355881
1727:Bibcode
1678:3097955
1642:Rowe WP
1474:CanSino
1469:Science
1453:T cells
1389:scholar
1354:removed
913:corneal
903:. Core
835:Animals
735:(binds
667:histone
659:nucleus
590:nucleus
588:in the
498:virions
460:obesity
269:viruses
185:Genera
161:Order:
149:Class:
9401:600012
9385:uBio:
9365:113665
8615:HTLV-I
8560:Rabies
8410:HTLV-I
6480:Genera
5554:Genera
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1133:bleach
947:, and
937:cattle
933:horses
873:canine
855:Myotis
817:Humans
757:primer
749:tumors
599:domain
582:genome
538:Genome
508:. 240
506:capsid
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324:genera
252:family
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8970:Mumps
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6193:III:
4369:Drugs
4335:Croup
4262:Fever
4252:Cough
3362:–13.
3265:S2CID
2810:17653
2472:S2CID
2281:S2CID
2122:S2CID
1674:S2CID
1428:HIV-1
1396:JSTOR
1382:books
1079:croup
1077:, or
949:goats
945:sheep
916:edema
803:fecal
769:lysis
755:as a
639:actin
562:genes
490:hexon
111:Realm
104:Virus
44:AD 48
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36:AD 26
9373:NCBI
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9347:GBIF
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8443:AIDS
8322:KSHV
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4135:ISSN
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4076:ISSN
4012:PMID
3967:2020
3940:PMID
3922:ISSN
3887:2020
3860:PMID
3807:PMID
3758:PMID
3732:Cell
3713:2020
3683:PMID
3635:2020
3578:PMID
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3507:2020
3501:(19)
3472:OCLC
3462:ISBN
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3402:PMID
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3333:PMID
3257:PMID
3194:PMID
3163:2021
3070:PMID
3019:PMID
2960:PMID
2917:ISBN
2891:PMID
2842:PMID
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2162:2021
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2114:PMID
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2000:PMID
1951:PMID
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1853:PMID
1804:PMID
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1700:2021
1666:PMID
1628:2021
1459:and
1444:and
1368:news
1337:for
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1195:SCID
1169:for
963:and
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909:dogs
907:for
891:and
883:and
858:and
603:CD46
521:cell
518:host
468:ICTV
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9334:EoL
9326:62M
9321:CoL
9205:MuV
9174:CBV
9149:HEV
9137:HDV
9125:HCV
9113:HAV
9106:CBV
9087:HBV
8964:MuV
8895:V,
8687:CBV
8656:HSV
8633:Eye
8520:LCV
8506:MeV
8437:HIV
8391:HCV
8336:EBV
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8269:HBV
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6180:RNA
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4431:DNA
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4125:doi
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