987:
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29:
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via activation of AdipoR1. As such, adiponectin receptor agonists are a highly interesting therapeutic target for a variety of different conditions. Moreover, it has been suggested they could potentially be used as a substitute for exercise to achieve similar physical and mental health benefits. In
416:
2016, the
University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1, AdipoR2, and AdipoRon identification data, as accused by an anonymous person/group called
678:
Nicolas S, Veyssière J, Gandin C, Zsürger N, Pietri M, Heurteaux C, et al. (July 2015). "Neurogenesis-independent antidepressant-like effects of enriched environment is dependent on adiponectin".
247:
971:
449:
Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, et al. (November 2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity".
55:
1032:
306:
348:. The compound was discovered by Japanese researchers in 2013 via screening of a compound library, and is the first orally active, small-molecule agonist of the
910:
1086:
261:
964:
726:
Li A, Yau SY, Machado S, Yuan TF, So KF (2015). "Adult
Neurogenic and Antidepressant Effects of Adiponectin: A Potential Replacement for Exercise?".
1076:
1051:
815:
Cho JK, Kim SU, Hong HR, Yoon JH, Kang HS (November 2015). "Exercise
Training Improves Whole Body Insulin Resistance via Adiponectin Receptor 1".
1061:
1025:
957:
1091:
860:"Fat cell-secreted adiponectin mediates physical exercise-induced hippocampal neurogenesis: an alternative anti-depressive treatment?"
1018:
364:
621:"Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin"
79:
1066:
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404:
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41:
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Adiponectin receptor agonists such as AdipoRon have attracted interest as potential therapies for obesity,
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911:"University of Tokyo to investigate data manipulation charges against six prominent research groups"
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572:"Perspective of Small-Molecule AdipoR Agonist for Type 2 Diabetes and Short Life in Obesity"
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Yau SY, Li A, Hoo RL, Ching YP, Christie BR, Lee TM, et al. (November 2014).
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Wędrychowicz A, Zając A, Pilecki M, Kościelniak B, Tomasik PJ (December 2014).
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Proceedings of the
National Academy of Sciences of the United States of America
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387:. Dysregulation of adiponectin expression has also been implicated in the
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Okada-Iwabu M, Iwabu M, Ueki K, Yamauchi T, Kadowaki T (October 2015).
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28:
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340:). Moreover, AdipoRon has been found to extend the lifespans of
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C1CN(CCC1NC(=O)COC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)CC4=CC=CC=C4
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515:"Cell Biology. Ronning after the adiponectin receptors"
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766:"Peptides from adipose tissue in mental disorders"
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301:= 1.8 μM and 3.1 μM, respectively). It activates
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728:CNS & Neurological Disorders Drug Targets
344:mice fed a high-fat diet, as well as improve
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371:has recently been elucidated to mediate the
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858:Yau SY, Li A, Xu A, So KF (January 2015).
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91:-(1-benzylpiperidin-4-yl)acetamide
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365:non-alcoholic fatty liver disease
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1077:Experimental anti-obesity drugs
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1:
1062:Adiponectin receptor agonists
1005:. You can help Knowledge by
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864:Neural Regeneration Research
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418:Ordinary_researchers
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631:(44): 15810–15815.
531:2013Sci...342.1460H
525:(6165): 1460–1461.
471:10.1038/nature12656
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322:glucose intolerance
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413:insulin resistance
352:to be identified.
346:exercise endurance
314:insulin resistance
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369:adiponectin
231: g·mol
110:924416-43-3
71:Identifiers
1057:Acetamides
1046:Categories
870:(1): 7–9.
424:References
381:neurogenic
377:anxiolytic
236:3D model (
224:Molar mass
175:ND7UVH6GKJ
146:ChemSpider
101:CAS Number
80:IUPAC name
686:: 72–83.
389:pathology
328:mice (an
310:signaling
42:Routes of
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