1372:
recent research, the roles of the AM1 and AM2 receptors have been clarified through studies in genetically manipulated mice. The adrenomedullin knockout is an embryonic lethal phenotype and dies mid gestation from a condition known as hydrops fetalis. The CALCRL or CLR KO mouse recapitulates the same phenotype, as it lacks both the AM1 and AM2 receptors (incidentally confirming the lack of physiological significance for the earlier single protein AM receptor discovered by Kapas). RAMP2 KO mice also recapitulates the same phenotype showing that major physiological effects of AM are transduced by the AM1 receptor. Even the heterozygote RAMP 2 mice have disturbed physiology with unusual bone and mammary gland defects, and very aberrant endocrinology, leading to poor fertility and lactation problems. What is very surprising is that the effect of deletion of RAMP3 has no deleterious effects and seems to confer advantages due to higher than normal bone mass, and reduced weight gain in older age.
1368:) or RAMP3, (known as AM1 and AM2 receptors respectively). Both transduce the hormone binding to intracellular signaling via second messenger cascades. The AM2 receptor has a low affinity for CGRP, but this is of no physiological relevance. Unlike the classical one ligand-one receptor notion of receptor signalling, the interaction of both CALCRL and RAMP at the membrane is required for AM to mediate its action: neither can bind the hormone (and therefore transduce a signal) alone. Stimulation by AM of its receptor increases production of both cyclic AMP (cAMP) and nitric oxide.
302:
279:
176:
201:
1342:
AM95-146. Mature human AM is activated to form a 52 amino acid, 6-amino acid ring, that shares moderate structural similarity to the calcitonin family of regulatory peptides (calcitonin, CGRP and amylin). Circulating AM consists of both amidated active form (15%) and the glycated inactive form (85%). It has a plasma half-life of 22min, mean clearance rate of 27.4 mL/kg/min, and apparent volume of distribution of 880 ± 150 mL/kg.
553:
308:
207:
1338:(CGRP). The precursor, called preproadrenomedullin, consists of 185 amino acids and can be cleaved by plasma kallikrein at the Lys-Arg and Arg-Arg sites. By RNA-blot analysis, human adrenomedullin mRNA was found to be expressed in all tissues, and most highly expressed in the placenta, fat cells, lung, pancreatic islets, smooth muscle, and skin.
1571:
Verweij, Niek; Mahmud, Hasan; Leach, Irene Mateo; de Boer, Rudolf A.; Brouwers, Frank P.; Yu, Hongjuan; Asselbergs, Folkert W.; Struck, Joachim; Bakker, Stephan J.L.; Gansevoort, Ron T.; Munroe, Patricia B.; Hillege, Hans L.; van
Veldhuisen, Dirk J.; van Gilst, Wiek H.; Silljé, Herman H.W.; van der
1371:
Before the discovery of the RAMPs and the identification of heteromeric receptors for the calcitonin family of peptides, a single G Protein coupled
Adrenomedullin receptor was identified, but more recent reports have cast doubts as to its importance in the major effects of adrenomedullin. In more
1341:
The human AM gene is localized to a single locus on
Chromosome 11 with 4 exons and 3 introns. The AM gene initially codes for a 185-amino acid precursor peptide, that can be differentially excised to form a number of peptides, including an inactive 53-amino acid AM, e PAMP, adrenotensin and
47:
1676:
McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor".
1466:
Kitamura K, Kato J, Kawamoto M, Tanaka M, Chino N, Kangawa K, Eto T (March 1998). "The intermediate form of glycine-extended adrenomedullin is the major circulating molecular form in human plasma".
2567:
1805:"Research resource: Haploinsufficiency of receptor activity-modifying protein-2 (RAMP2) causes reduced fertility, hyperprolactinemia, skeletal abnormalities, and endocrine dysfunction in mice"
1501:
Fujisawa Y, Nagai Y, Miyatake A, Takei Y, Miura K, Shoukouji T, Nishiyama A, Kimura S, Abe Y (August 2004). "Renal effects of a new member of adrenomedullin family, adrenomedullin2, in rats".
1306:. ADM is a peptide expressed by all tissues, and found in the circulation. A similar peptide named adreomedullin2 was reported in rats in 2004 which exhibits a similar function.
1926:
Cao YN, Kitamura K, Ito K, Kato J, Hashida S, Morishita K, Eto T (May 2003). "Glycine-extended adrenomedullin exerts vasodilator effect through amidation in the rat aorta".
315:
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1637:"Circulating adrenomedullin does not regulate systemic blood pressure but increases plasma prolactin after intravenous infusion in humans: a pharmacokinetic study"
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1326:
found in the body. Differences in opinion regarding the ability of AM to relax vascular tone may arise from the differences in the model system used.
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Hamid SA, Baxter GF (February 2005). "Adrenomedullin: regulator of systemic and cardiac homeostasis in acute myocardial infarction".
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in the circulation control because it is found in blood in a considerable concentration. It was initially identified as a
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3710:
3700:
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Adrenomedullin consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the
5417:
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2347:
2312:
2149:
314:
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1854:"Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age"
5325:
1574:"Genome-Wide Association Study on Plasma Levels of Midregional-Proadrenomedullin and C-Terminal-Pro-Endothelin-1"
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Adrenomedullin (AM) exerts its actions through combinations of the calcitonin receptor like receptor (
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of uncertain significance in human health and disease. It was initially isolated in 1993 from a
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2013:
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Morfis M, Christopoulos A, Sexton PM (November 2003). "RAMPs: 5 years on, where to now?".
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369:
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Kadmiel M, Fritz-Six K, Pacharne S, Richards GO, Li M, Skerry TM, Caron KM (July 2011).
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Meeran K, O'Shea D, Upton PD, Small CJ, Ghatei MA, Byfield PH, Bloom SR (January 1997).
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1965:"Haemodynamic effects of adrenomedullin in human resistance and capacitance vessels"
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National Center for
Biotechnology Information, U.S. National Library of Medicine
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National Center for
Biotechnology Information, U.S. National Library of Medicine
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1727:
Hay DL, Poyner DR, Sexton PM (January 2006). "GPCR modulation by RAMPs".
1242:
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902:
adenylate cyclase-activating G protein-coupled receptor signaling pathway
1621:
5427:
4848:
4313:
3715:
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2421:
2360:
1764:"Cloning and expression of cDNA encoding a rat adrenomedullin receptor"
1323:
1315:
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1023:
877:
antimicrobial humoral immune response mediated by antimicrobial peptide
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1322:, and some argued that it is the most potent endogenous vasodilatory
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2124:
2116:
1963:
Cockcroft JR, Noon JP, Gardner-Medwin J, Bennett T (July 1997).
1303:
121:
2549:
2059:
561:
722:
positive regulation of cytosolic calcium ion concentration
1584:(3). Ovid Technologies (Wolters Kluwer Health): 602–608.
1852:
Dackor R, Fritz-Six K, Smithies O, Caron K (June 2007).
927:
positive regulation of progesterone biosynthetic process
377:
5443:
Pituitary adenylate cyclase-activating peptide (PACAP)
667:
branching involved in labyrinthine layer morphogenesis
542:
802:
positive regulation of cell population proliferation
652:
negative regulation of cell population proliferation
5310:
5097:
4992:
4761:
4501:
4492:
4472:
4386:
4363:
4332:
4301:
4270:
4234:
4225:
4077:
3920:
3853:
3815:
3682:
3673:
3491:
3468:
3408:
3327:
3194:
3111:
3102:
3041:
2987:
2900:
2704:
2695:
2664:
2586:
2522:
2484:
2451:
2388:
2357:
2346:
2311:
2283:
2241:
2202:
2146:
2102:
2093:
1187:
1166:
1140:
1119:
5389:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
4247:Glial cell line-derived neurotrophic factor (GDNF)
3900:Cleavage products/derivatives with unknown target:
1409:
1407:
1405:
1388:
1386:
1384:
712:vascular associated smooth muscle cell development
324:
223:
5423:Macrophage-stimulating protein (MSP; HLP, HGFLP)
3064:Heparin-binding EGF-like growth factor (HB-EGF)
2747:Heparin-binding EGF-like growth factor (HB-EGF)
1414:GRCm38: Ensembl release 89: ENSMUSG00000030790
882:regulation of systemic arterial blood pressure
5475:Additional growth factor receptor modulators:
2561:
2071:
8:
3829:Insulin-like growth factor-2 (somatomedin A)
3711:Insulin-like growth factor-2 (somatomedin A)
3701:Insulin-like growth factor-1 (somatomedin C)
897:G protein-coupled receptor signaling pathway
827:negative regulation of vascular permeability
762:regulation of the force of heart contraction
1762:Kapas S, Catt KJ, Clark AJ (October 1995).
1393:GRCh38: Ensembl release 89: ENSG00000148926
717:defense response to Gram-positive bacterium
677:defense response to Gram-negative bacterium
4498:
4231:
3679:
3108:
2701:
2568:
2554:
2546:
2354:
2099:
2078:
2064:
2056:
2046:United States National Library of Medicine
952:
737:G protein-coupled receptor internalization
577:
365:
264:
161:
55:
2016:at the U.S. National Library of Medicine
1988:
1869:
1828:
1779:
1652:
1589:
917:adrenomedullin receptor signaling pathway
907:regulation of signaling receptor activity
5433:Migration-stimulating factor (MSF; PRG4)
2044:This article incorporates text from the
852:odontogenesis of dentin-containing tooth
767:positive regulation of apoptotic process
2762:Transforming growth factor alpha (TGFα)
1380:
732:negative regulation of vasoconstriction
5336:Connective tissue growth factor (CTGF)
15:
5399:Hepatoma-derived growth factor (HDGF)
782:positive regulation of vasculogenesis
329:
290:
285:
228:
187:
182:
7:
857:spongiotrophoblast layer development
485:endothelial cell of lymphatic vessel
1362:Receptor activity-modifying protein
842:positive regulation of angiogenesis
1591:10.1161/hypertensionaha.111.203117
1184:
1163:
1137:
1116:
1092:
1073:
1047:
1028:
1002:
983:
547:
465:
403:
382:
14:
1314:Adrenomedullin may function as a
912:amylin receptor signaling pathway
887:positive regulation of heart rate
822:progesterone biosynthetic process
5418:Leukemia inhibitory factor (LIF)
1981:10.1046/j.1365-2125.1997.00622.x
1741:10.1016/j.pharmthera.2005.06.015
1550:10.1016/j.pharmthera.2004.08.012
1299:In humans ADM is encoded by the
551:
313:
306:
300:
277:
212:
205:
199:
174:
4586:Negative allosteric modulators:
2392:Relaxin family peptide hormones
1336:calcitonin gene-related peptide
605:adrenomedullin receptor binding
108:, Adm, AM, PAMP, adrenomedullin
4904:Gossypetin (3,5,7,8,3',4'-HHF)
4095:Platelet-derived growth factor
787:neuron projection regeneration
707:response to lipopolysaccharide
672:antibacterial humoral response
562:More reference expression data
531:More reference expression data
1:
5110:Placental growth factor (PGF)
1940:10.1016/s0167-0115(03)00002-8
1622:"Entrez Gene: Adrenomedullin"
1468:Biochem. Biophys. Res. Commun
847:response to organic substance
298:
197:
5500:Genes on human chromosome 11
5394:Glia maturation factor (GMF)
3903:Glypromate (GPE, (1-3)IGF-1)
1515:10.1016/j.ejphar.2004.06.039
797:antifungal humoral response
443:stromal cell of endometrium
5521:
5326:Colony-stimulating factors
5318:Additional growth factors:
2365:Insulin-like growth factor
2035:gene details page in the
1911:10.1016/j.tips.2003.09.001
1641:J. Clin. Endocrinol. Metab
1349:
892:regulation of urine volume
832:androgen metabolic process
807:response to glucocorticoid
595:signaling receptor binding
497:superior cervical ganglion
4674:SNA-120 (pegylated K252a)
3846:(against IGF-1 and IGF-2)
3808:(against IGF-1 and IGF-2)
1449:"Mouse PubMed Reference:"
1431:"Human PubMed Reference:"
1257:
1252:
1248:
1241:
1225:
1219:Chr 7: 110.23 – 110.23 Mb
1206:
1191:
1170:
1159:
1144:
1123:
1112:
1099:
1095:
1080:
1076:
1067:
1054:
1050:
1035:
1031:
1022:
1009:
1005:
990:
986:
977:
962:
955:
951:
935:
872:cAMP biosynthetic process
697:animal organ regeneration
580:
576:
559:
550:
541:
528:
477:
468:
415:
406:
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368:
364:
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115:
112:
102:
95:
90:
63:
58:
41:
36:
31:
27:
23:
18:
3510:Hepatocyte growth factor
3069:Neuregulins (heregulins)
3000:Neuregulins (heregulins)
2944:Trastuzumab duocarmazine
2657:(against angiopoietin 2)
2651:(against angiopoietin 3)
2018:Medical Subject Headings
1781:10.1074/jbc.270.43.25344
1212:Chr 11: 10.31 – 10.31 Mb
682:receptor internalization
2857:Depatuxizumab mafodotin
2205:FGF homologous factors:
1352:Adrenomedullin receptor
747:calcium ion homeostasis
742:cAMP-mediated signaling
5480:(neurotrophin mixture)
5468:Wnt signaling proteins
5149:Allosteric modulators:
4869:Norwogonin (5,7,8-THF)
3089:5 (tomoregulin, TMEFF)
2939:Trastuzumab deruxtecan
2577:Growth factor receptor
1871:10.1074/jbc.M703544200
1654:10.1210/jcem.82.1.3656
1480:10.1006/bbrc.1998.8310
1360:) or CLR; and either (
752:response to starvation
509:trophoblast giant cell
5408:T-cell growth factors
3665:Telisotuzumab vedotin
2949:Trastuzumab emtansine
1899:Trends Pharmacol. Sci
922:inflammatory response
501:epithelium of stomach
489:stroma of bone marrow
190:Chromosome 11 (human)
3993:EVT-901 (SAR-127963)
3726:Mecasermin rinfabate
2486:Vascular endothelial
2029:genome location and
1821:10.1210/me.2010-0400
867:response to wounding
812:developmental growth
626:extracellular region
292:Chromosome 7 (mouse)
59:List of PDB id codes
32:Available structures
2037:UCSC Genome Browser
1969:Br J Clin Pharmacol
1690:1998Natur.393..333M
1572:Harst, Pim (2013).
837:response to insulin
702:cell-cell signaling
692:signal transduction
662:neural tube closure
657:response to hypoxia
636:extracellular space
331:7 E3|7 57.7 cM
5159:Kinase inhibitors:
5022:Kinase inhibitors:
4921:Kinase inhibitors:
4596:Kinase inhibitors:
4411:Kinase inhibitors:
4371:Kinase inhibitors:
4352:Kinase inhibitors:
4321:Kinase inhibitors:
4290:Kinase inhibitors:
4259:Kinase inhibitors:
4119:Kinase inhibitors:
3733:Kinase inhibitors:
3527:Kinase inhibitors:
3316:Kinase inhibitors:
3309:Aprutumab ixadotin
2956:Kinase inhibitors:
2769:Kinase inhibitors:
2626:Kinase inhibitors:
2048:, which is in the
1296:: hence the name.
1057:ENSMUSG00000030790
645:Biological process
619:Cellular component
588:Molecular function
5487:
5486:
5093:
5092:
4854:N-Acetylserotonin
4753:ReN-1820 (TrkAd5)
4382:
4381:
3916:
3915:
3861:Binding proteins:
3520:Dihexa (PNB-0408)
3487:
3486:
3098:
3097:
3012:6 (neuroglycan C)
2732:EGF (urogastrone)
2710:
2543:
2542:
2447:
2446:
2279:
2278:
1503:Eur. J. Pharmacol
1292:, a tumor of the
1268:
1267:
1264:
1263:
1237:
1236:
1202:
1201:
1181:
1180:
1155:
1154:
1134:
1133:
1108:
1107:
1089:
1088:
1063:
1062:
1044:
1043:
1018:
1017:
999:
998:
947:
946:
792:hormone secretion
772:response to yeast
757:heart development
687:blood circulation
572:
571:
568:
567:
537:
536:
524:
523:
462:
461:
360:
359:
259:
258:
86:
85:
82:
81:
42:Ortholog search:
5512:
5299:Decoy receptors:
5272:Alacizumab pegol
4750:Decoy receptors:
4499:
4404:Stem cell factor
4345:Persephin (PSPN)
4283:Neurturin (NRTN)
4232:
4069:LEVI-04 (p75-Fc)
4066:Decoy receptors:
3680:
3109:
2708:
2702:
2570:
2563:
2556:
2547:
2453:Platelet-derived
2395:
2368:
2355:
2249:
2207:
2153:
2110:
2100:
2080:
2073:
2066:
2057:
2002:
1992:
1959:
1922:
1884:
1883:
1873:
1849:
1843:
1842:
1832:
1800:
1794:
1793:
1783:
1759:
1753:
1752:
1724:
1718:
1717:
1673:
1667:
1666:
1656:
1632:
1626:
1625:
1618:
1612:
1611:
1593:
1568:
1562:
1561:
1533:
1527:
1526:
1498:
1492:
1491:
1463:
1457:
1456:
1445:
1439:
1438:
1427:
1421:
1411:
1400:
1390:
1290:pheochromocytoma
1250:
1249:
1221:
1214:
1197:
1185:
1176:
1164:
1160:RefSeq (protein)
1150:
1138:
1129:
1117:
1093:
1074:
1048:
1029:
1003:
984:
953:
862:female pregnancy
777:response to cold
600:hormone activity
578:
564:
555:
548:
533:
517:stria vascularis
473:
471:Top expressed in
466:
431:cartilage tissue
411:
409:Top expressed in
404:
383:
366:
356:
343:
332:
317:
310:
304:
293:
281:
265:
255:
242:
231:
216:
209:
203:
192:
178:
162:
156:
107:
100:
77:
56:
50:
29:
28:
16:
5520:
5519:
5515:
5514:
5513:
5511:
5510:
5509:
5490:
5489:
5488:
5483:
5428:Midkine (NEGF2)
5306:
5089:
4988:
4757:
4695:ABT-110 (PG110)
4488:
4468:
4378:
4359:
4328:
4297:
4266:
4221:
4073:
4011:ABT-110 (PG110)
3912:
3849:
3811:
3669:
3483:
3464:
3404:
3401:(against FGF23)
3323:
3190:
3094:
3037:
2983:
2896:
2707:
2691:
2660:
2582:
2574:
2544:
2539:
2518:
2480:
2443:
2389:
2384:
2358:
2349:
2342:
2307:
2285:EGF-like domain
2275:
2242:
2237:
2203:
2198:
2147:
2142:
2103:
2089:
2084:
2010:
2005:
1962:
1934:(1–3): 109–14.
1925:
1905:(11): 596–601.
1896:
1892:
1890:Further reading
1887:
1864:(25): 18094–9.
1851:
1850:
1846:
1809:Mol. Endocrinol
1802:
1801:
1797:
1774:(43): 25344–7.
1761:
1760:
1756:
1735:(1–2): 173–97.
1729:Pharmacol. Ther
1726:
1725:
1721:
1684:(6683): 333–9.
1675:
1674:
1670:
1634:
1633:
1629:
1620:
1619:
1615:
1570:
1569:
1565:
1538:Pharmacol. Ther
1535:
1534:
1530:
1500:
1499:
1495:
1465:
1464:
1460:
1447:
1446:
1442:
1429:
1428:
1424:
1412:
1403:
1391:
1382:
1378:
1354:
1348:
1332:
1312:
1294:adrenal medulla
1286:peptide hormone
1259:View/Edit Mouse
1254:View/Edit Human
1217:
1210:
1207:Location (UCSC)
1193:
1172:
1146:
1125:
1038:ENSG00000148926
931:
640:
614:
610:protein binding
560:
529:
520:
515:
513:renal corpuscle
511:
507:
503:
499:
495:
491:
487:
483:
469:
458:
453:
449:
445:
441:
437:
433:
429:
425:
421:
407:
351:
338:
330:
320:
319:
318:
311:
291:
268:Gene location (
250:
237:
229:
219:
218:
217:
210:
188:
165:Gene location (
154:ADM - orthologs
116:
103:
96:
65:
43:
12:
11:
5:
5518:
5516:
5508:
5507:
5502:
5492:
5491:
5485:
5484:
5482:
5481:
5471:
5470:
5465:
5458:Thrombopoietin
5455:
5450:
5445:
5440:
5435:
5430:
5425:
5420:
5415:
5401:
5396:
5391:
5386:
5379:Erythropoietin
5376:
5338:
5333:
5323:
5321:Adrenomedullin
5314:
5312:
5308:
5307:
5305:
5304:
5295:
5294:
5289:
5284:
5279:
5274:
5265:
5264:
5259:
5254:
5249:
5244:
5239:
5234:
5229:
5224:
5219:
5214:
5209:
5204:
5199:
5194:
5189:
5184:
5179:
5174:
5169:
5164:
5155:
5154:
5145:
5144:
5122:
5117:
5112:
5103:
5101:
5095:
5094:
5091:
5090:
5088:
5087:
5082:
5077:
5072:
5067:
5062:
5057:
5052:
5047:
5042:
5037:
5032:
5027:
5018:
5017:
5012:
5007:
4998:
4996:
4990:
4989:
4987:
4986:
4981:
4976:
4971:
4966:
4961:
4956:
4951:
4946:
4941:
4936:
4931:
4926:
4917:
4916:
4907:
4906:
4901:
4896:
4887:
4886:
4881:
4876:
4871:
4866:
4861:
4856:
4851:
4846:
4841:
4836:
4831:
4826:
4821:
4816:
4811:
4806:
4801:
4796:
4791:
4786:
4784:4'-DMA-7,8-DHF
4781:
4776:
4767:
4765:
4759:
4758:
4756:
4755:
4746:
4745:
4733:
4732:
4727:
4722:
4717:
4712:
4707:
4702:
4697:
4678:
4677:
4671:
4666:
4661:
4656:
4651:
4646:
4641:
4636:
4631:
4626:
4621:
4616:
4611:
4606:
4601:
4592:
4591:
4582:
4581:
4576:
4571:
4566:
4557:
4556:
4551:
4546:
4544:Gambogic amide
4541:
4536:
4531:
4526:
4521:
4516:
4507:
4505:
4496:
4490:
4489:
4487:
4486:
4478:
4476:
4470:
4469:
4467:
4466:
4461:
4456:
4451:
4446:
4441:
4436:
4431:
4426:
4421:
4416:
4407:
4406:
4401:
4392:
4390:
4384:
4383:
4380:
4379:
4377:
4376:
4367:
4365:
4361:
4360:
4358:
4357:
4348:
4347:
4338:
4336:
4330:
4329:
4327:
4326:
4317:
4316:
4314:Artemin (ARTN)
4307:
4305:
4299:
4298:
4296:
4295:
4286:
4285:
4276:
4274:
4268:
4267:
4265:
4264:
4255:
4254:
4249:
4240:
4238:
4229:
4223:
4222:
4220:
4219:
4214:
4209:
4200:
4199:
4194:
4189:
4184:
4179:
4174:
4169:
4164:
4159:
4154:
4149:
4144:
4139:
4134:
4129:
4124:
4115:
4114:
4092:
4083:
4081:
4075:
4074:
4072:
4071:
4062:
4061:
4049:
4048:
4043:
4038:
4033:
4028:
4023:
4018:
4013:
4001:
4000:
3995:
3990:
3985:
3976:
3975:
3970:
3965:
3960:
3955:
3950:
3945:
3940:
3935:
3926:
3924:
3918:
3917:
3914:
3913:
3911:
3910:
3905:
3896:
3895:
3857:
3855:
3851:
3850:
3848:
3847:
3841:
3832:
3831:
3821:
3819:
3813:
3812:
3810:
3809:
3803:
3798:
3793:
3788:
3783:
3778:
3773:
3768:
3759:
3758:
3753:
3748:
3743:
3738:
3729:
3728:
3723:
3718:
3713:
3708:
3703:
3698:
3688:
3686:
3677:
3671:
3670:
3668:
3667:
3662:
3657:
3652:
3647:
3642:
3637:
3628:
3627:
3622:
3617:
3612:
3607:
3602:
3597:
3592:
3587:
3582:
3577:
3572:
3567:
3562:
3557:
3552:
3547:
3542:
3537:
3532:
3523:
3522:
3513:
3512:
3507:
3497:
3495:
3489:
3488:
3485:
3484:
3482:
3481:
3472:
3470:
3466:
3465:
3463:
3462:
3457:
3423:
3414:
3412:
3406:
3405:
3403:
3402:
3392:
3391:
3386:
3381:
3376:
3342:
3333:
3331:
3325:
3324:
3322:
3321:
3312:
3311:
3306:
3297:
3296:
3291:
3286:
3281:
3276:
3271:
3209:
3200:
3198:
3192:
3191:
3189:
3188:
3183:
3178:
3173:
3168:
3126:
3117:
3115:
3106:
3100:
3099:
3096:
3095:
3093:
3092:
3066:
3061:
3056:
3047:
3045:
3039:
3038:
3036:
3035:
3030:
3025:
3016:
3015:
2993:
2991:
2985:
2984:
2982:
2981:
2976:
2971:
2966:
2961:
2952:
2951:
2946:
2941:
2936:
2931:
2926:
2917:
2916:
2906:
2904:
2898:
2897:
2895:
2894:
2889:
2884:
2879:
2874:
2869:
2864:
2859:
2854:
2849:
2840:
2839:
2834:
2829:
2824:
2819:
2814:
2809:
2804:
2799:
2794:
2789:
2784:
2779:
2774:
2765:
2764:
2759:
2754:
2749:
2744:
2739:
2734:
2729:
2724:
2714:
2712:
2699:
2693:
2692:
2690:
2689:
2684:
2679:
2670:
2668:
2662:
2661:
2659:
2658:
2652:
2642:
2641:
2636:
2631:
2622:
2621:
2619:Angiopoietin 3
2616:
2614:Angiopoietin 2
2607:
2606:
2604:Angiopoietin 4
2601:
2599:Angiopoietin 1
2592:
2590:
2584:
2583:
2575:
2573:
2572:
2565:
2558:
2550:
2541:
2540:
2538:
2537:
2532:
2526:
2524:
2520:
2519:
2517:
2516:
2511:
2506:
2501:
2496:
2490:
2488:
2482:
2481:
2479:
2478:
2473:
2468:
2463:
2457:
2455:
2449:
2448:
2445:
2444:
2442:
2441:
2440:
2439:
2434:
2429:
2419:
2414:
2409:
2404:
2398:
2396:
2386:
2385:
2383:
2382:
2377:
2371:
2369:
2352:
2350:Relaxin family
2344:
2343:
2341:
2340:
2339:
2338:
2333:
2328:
2317:
2315:
2309:
2308:
2306:
2305:
2300:
2295:
2289:
2287:
2281:
2280:
2277:
2276:
2274:
2273:
2268:
2263:
2258:
2252:
2250:
2239:
2238:
2236:
2235:
2229:
2223:
2217:
2210:
2208:
2200:
2199:
2197:
2196:
2183:
2170:
2156:
2154:
2144:
2143:
2141:
2140:
2127:
2113:
2111:
2097:
2091:
2090:
2087:Growth factors
2085:
2083:
2082:
2075:
2068:
2060:
2041:
2040:
2021:
2014:Adrenomedullin
2009:
2008:External links
2006:
2004:
2003:
1960:
1923:
1893:
1891:
1888:
1886:
1885:
1844:
1815:(7): 1244–53.
1795:
1754:
1719:
1668:
1627:
1613:
1563:
1528:
1493:
1458:
1440:
1422:
1401:
1379:
1377:
1374:
1350:Main article:
1347:
1344:
1331:
1328:
1311:
1308:
1271:Adrenomedullin
1266:
1265:
1262:
1261:
1256:
1246:
1245:
1239:
1238:
1235:
1234:
1232:
1230:
1223:
1222:
1215:
1208:
1204:
1203:
1200:
1199:
1189:
1188:
1182:
1179:
1178:
1168:
1167:
1161:
1157:
1156:
1153:
1152:
1142:
1141:
1135:
1132:
1131:
1121:
1120:
1114:
1110:
1109:
1106:
1105:
1097:
1096:
1090:
1087:
1086:
1078:
1077:
1071:
1065:
1064:
1061:
1060:
1052:
1051:
1045:
1042:
1041:
1033:
1032:
1026:
1020:
1019:
1016:
1015:
1007:
1006:
1000:
997:
996:
988:
987:
981:
975:
974:
969:
964:
960:
959:
949:
948:
945:
944:
933:
932:
930:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
727:vasculogenesis
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
648:
646:
642:
641:
639:
638:
633:
628:
622:
620:
616:
615:
613:
612:
607:
602:
597:
591:
589:
585:
584:
574:
573:
570:
569:
566:
565:
557:
556:
545:
539:
538:
535:
534:
526:
525:
522:
521:
519:
518:
514:
510:
506:
502:
498:
494:
490:
486:
482:
478:
475:
474:
463:
460:
459:
457:
456:
452:
451:synovial joint
448:
444:
440:
436:
435:saphenous vein
432:
428:
424:
420:
416:
413:
412:
400:
399:
391:
380:
374:
373:
370:RNA expression
362:
361:
358:
357:
349:
345:
344:
336:
333:
328:
322:
321:
312:
305:
299:
295:
294:
289:
283:
282:
274:
273:
261:
260:
257:
256:
248:
244:
243:
235:
232:
227:
221:
220:
211:
204:
198:
194:
193:
186:
180:
179:
171:
170:
158:
157:
114:
110:
109:
101:
93:
92:
88:
87:
84:
83:
80:
79:
61:
60:
52:
51:
40:
34:
33:
25:
24:
21:
20:
13:
10:
9:
6:
4:
3:
2:
5517:
5506:
5505:Endocrinology
5503:
5501:
5498:
5497:
5495:
5479:
5476:
5473:
5472:
5469:
5466:
5463:
5459:
5456:
5454:
5451:
5449:
5446:
5444:
5441:
5439:
5436:
5434:
5431:
5429:
5426:
5424:
5421:
5419:
5416:
5413:
5409:
5405:
5402:
5400:
5397:
5395:
5392:
5390:
5387:
5384:
5380:
5377:
5374:
5370:
5366:
5362:
5358:
5354:
5350:
5346:
5342:
5339:
5337:
5334:
5331:
5327:
5324:
5322:
5319:
5316:
5315:
5313:
5309:
5303:
5300:
5297:
5296:
5293:
5290:
5288:
5285:
5283:
5280:
5278:
5275:
5273:
5270:
5267:
5266:
5263:
5260:
5258:
5255:
5253:
5250:
5248:
5245:
5243:
5240:
5238:
5235:
5233:
5230:
5228:
5225:
5223:
5220:
5218:
5215:
5213:
5210:
5208:
5205:
5203:
5200:
5198:
5195:
5193:
5190:
5188:
5185:
5183:
5180:
5178:
5175:
5173:
5170:
5168:
5165:
5163:
5160:
5157:
5156:
5153:
5152:Cyclotraxin B
5150:
5147:
5146:
5142:
5138:
5134:
5130:
5126:
5123:
5121:
5118:
5116:
5113:
5111:
5108:
5105:
5104:
5102:
5100:
5096:
5086:
5083:
5081:
5078:
5076:
5073:
5071:
5068:
5066:
5065:Larotrectinib
5063:
5061:
5058:
5056:
5053:
5051:
5048:
5046:
5043:
5041:
5038:
5036:
5033:
5031:
5028:
5026:
5023:
5020:
5019:
5016:
5013:
5011:
5008:
5006:
5003:
5000:
4999:
4997:
4995:
4991:
4985:
4982:
4980:
4977:
4975:
4972:
4970:
4967:
4965:
4964:Larotrectinib
4962:
4960:
4957:
4955:
4952:
4950:
4947:
4945:
4942:
4940:
4937:
4935:
4932:
4930:
4927:
4925:
4922:
4919:
4918:
4915:
4912:
4909:
4908:
4905:
4902:
4900:
4899:Cyclotraxin B
4897:
4895:
4892:
4889:
4888:
4885:
4882:
4880:
4877:
4875:
4872:
4870:
4867:
4865:
4862:
4860:
4857:
4855:
4852:
4850:
4847:
4845:
4842:
4840:
4837:
4835:
4832:
4830:
4827:
4825:
4822:
4820:
4817:
4815:
4812:
4810:
4809:Amitriptyline
4807:
4805:
4802:
4800:
4797:
4795:
4792:
4790:
4787:
4785:
4782:
4780:
4777:
4775:
4772:
4769:
4768:
4766:
4764:
4760:
4754:
4751:
4748:
4747:
4744:
4741:
4738:
4735:
4734:
4731:
4728:
4726:
4723:
4721:
4718:
4716:
4713:
4711:
4708:
4706:
4703:
4701:
4698:
4696:
4693:
4689:
4686:
4685:Against TrkA:
4683:
4680:
4679:
4675:
4672:
4670:
4667:
4665:
4662:
4660:
4657:
4655:
4652:
4650:
4647:
4645:
4642:
4640:
4639:Larotrectinib
4637:
4635:
4632:
4630:
4627:
4625:
4622:
4620:
4617:
4615:
4612:
4610:
4607:
4605:
4602:
4600:
4597:
4594:
4593:
4590:
4587:
4584:
4583:
4580:
4577:
4575:
4572:
4570:
4569:Dexamethasone
4567:
4565:
4562:
4559:
4558:
4555:
4552:
4550:
4547:
4545:
4542:
4540:
4537:
4535:
4532:
4530:
4527:
4525:
4522:
4520:
4517:
4515:
4514:Amitriptyline
4512:
4509:
4508:
4506:
4504:
4500:
4497:
4495:
4491:
4484:
4480:
4479:
4477:
4475:
4471:
4465:
4462:
4460:
4457:
4455:
4452:
4450:
4447:
4445:
4442:
4440:
4437:
4435:
4432:
4430:
4427:
4425:
4422:
4420:
4417:
4415:
4412:
4409:
4408:
4405:
4402:
4400:
4397:
4394:
4393:
4391:
4389:
4385:
4375:
4372:
4369:
4368:
4366:
4362:
4356:
4353:
4350:
4349:
4346:
4343:
4340:
4339:
4337:
4335:
4331:
4325:
4322:
4319:
4318:
4315:
4312:
4309:
4308:
4306:
4304:
4300:
4294:
4291:
4288:
4287:
4284:
4281:
4278:
4277:
4275:
4273:
4269:
4263:
4260:
4257:
4256:
4253:
4250:
4248:
4245:
4242:
4241:
4239:
4237:
4233:
4230:
4228:
4224:
4218:
4215:
4213:
4210:
4208:
4205:
4202:
4201:
4198:
4195:
4193:
4190:
4188:
4185:
4183:
4180:
4178:
4175:
4173:
4170:
4168:
4165:
4163:
4160:
4158:
4155:
4153:
4150:
4148:
4145:
4143:
4140:
4138:
4135:
4133:
4130:
4128:
4125:
4123:
4120:
4117:
4116:
4112:
4108:
4104:
4100:
4096:
4093:
4091:
4088:
4085:
4084:
4082:
4080:
4076:
4070:
4067:
4064:
4063:
4060:
4057:
4054:
4051:
4050:
4047:
4044:
4042:
4039:
4037:
4034:
4032:
4029:
4027:
4024:
4022:
4019:
4017:
4014:
4012:
4009:
4006:
4003:
4002:
3999:
3996:
3994:
3991:
3989:
3988:Dexamethasone
3986:
3984:
3981:
3978:
3977:
3974:
3971:
3969:
3966:
3964:
3961:
3959:
3956:
3954:
3951:
3949:
3946:
3944:
3941:
3939:
3936:
3934:
3931:
3928:
3927:
3925:
3923:
3919:
3909:
3906:
3904:
3901:
3898:
3897:
3893:
3889:
3885:
3881:
3877:
3873:
3869:
3865:
3862:
3859:
3858:
3856:
3852:
3845:
3842:
3840:
3837:
3834:
3833:
3830:
3826:
3823:
3822:
3820:
3818:
3814:
3807:
3804:
3802:
3799:
3797:
3794:
3792:
3789:
3787:
3784:
3782:
3779:
3777:
3774:
3772:
3769:
3767:
3764:
3761:
3760:
3757:
3754:
3752:
3749:
3747:
3744:
3742:
3739:
3737:
3734:
3731:
3730:
3727:
3724:
3722:
3719:
3717:
3714:
3712:
3709:
3707:
3704:
3702:
3699:
3697:
3696:des(1-3)IGF-1
3693:
3690:
3689:
3687:
3685:
3681:
3678:
3676:
3672:
3666:
3663:
3661:
3660:Telisotuzumab
3658:
3656:
3653:
3651:
3648:
3646:
3643:
3641:
3638:
3636:
3633:
3630:
3629:
3626:
3623:
3621:
3618:
3616:
3613:
3611:
3608:
3606:
3603:
3601:
3598:
3596:
3593:
3591:
3588:
3586:
3583:
3581:
3578:
3576:
3573:
3571:
3568:
3566:
3563:
3561:
3558:
3556:
3553:
3551:
3548:
3546:
3543:
3541:
3538:
3536:
3533:
3531:
3528:
3525:
3524:
3521:
3518:
3517:Potentiators:
3515:
3514:
3511:
3508:
3506:
3502:
3499:
3498:
3496:
3494:
3490:
3480:
3477:
3474:
3473:
3471:
3467:
3461:
3458:
3455:
3451:
3447:
3443:
3439:
3435:
3431:
3427:
3424:
3422:
3419:
3416:
3415:
3413:
3411:
3407:
3400:
3397:
3394:
3393:
3390:
3387:
3385:
3382:
3380:
3379:Selpercatinib
3377:
3374:
3370:
3366:
3362:
3358:
3354:
3350:
3346:
3343:
3341:
3338:
3335:
3334:
3332:
3330:
3326:
3320:
3317:
3314:
3313:
3310:
3307:
3305:
3302:
3299:
3298:
3295:
3292:
3290:
3287:
3285:
3284:Selpercatinib
3282:
3280:
3277:
3275:
3272:
3269:
3265:
3261:
3257:
3253:
3249:
3245:
3241:
3237:
3233:
3229:
3225:
3221:
3217:
3213:
3210:
3208:
3205:
3202:
3201:
3199:
3197:
3193:
3187:
3184:
3182:
3179:
3177:
3176:Selpercatinib
3174:
3172:
3169:
3166:
3162:
3158:
3154:
3150:
3146:
3142:
3138:
3134:
3130:
3127:
3125:
3122:
3119:
3118:
3116:
3114:
3110:
3107:
3105:
3101:
3090:
3086:
3082:
3078:
3074:
3070:
3067:
3065:
3062:
3060:
3057:
3055:
3052:
3049:
3048:
3046:
3044:
3040:
3034:
3031:
3029:
3026:
3024:
3021:
3018:
3017:
3013:
3009:
3005:
3001:
2998:
2995:
2994:
2992:
2990:
2986:
2980:
2977:
2975:
2972:
2970:
2967:
2965:
2962:
2960:
2957:
2954:
2953:
2950:
2947:
2945:
2942:
2940:
2937:
2935:
2932:
2930:
2927:
2925:
2922:
2919:
2918:
2915:
2911:
2908:
2907:
2905:
2903:
2899:
2893:
2890:
2888:
2885:
2883:
2880:
2878:
2875:
2873:
2870:
2868:
2865:
2863:
2860:
2858:
2855:
2853:
2852:Depatuxizumab
2850:
2848:
2845:
2842:
2841:
2838:
2835:
2833:
2830:
2828:
2825:
2823:
2820:
2818:
2815:
2813:
2810:
2808:
2805:
2803:
2800:
2798:
2795:
2793:
2790:
2788:
2785:
2783:
2780:
2778:
2775:
2773:
2770:
2767:
2766:
2763:
2760:
2758:
2755:
2753:
2750:
2748:
2745:
2743:
2740:
2738:
2735:
2733:
2730:
2728:
2725:
2723:
2719:
2716:
2715:
2713:
2711:
2703:
2700:
2698:
2694:
2688:
2685:
2683:
2680:
2678:
2675:
2672:
2671:
2669:
2667:
2663:
2656:
2653:
2650:
2647:
2644:
2643:
2640:
2637:
2635:
2632:
2630:
2627:
2624:
2623:
2620:
2617:
2615:
2612:
2609:
2608:
2605:
2602:
2600:
2597:
2594:
2593:
2591:
2589:
2585:
2581:
2578:
2571:
2566:
2564:
2559:
2557:
2552:
2551:
2548:
2536:
2533:
2531:
2528:
2527:
2525:
2521:
2515:
2512:
2510:
2507:
2505:
2502:
2500:
2497:
2495:
2492:
2491:
2489:
2487:
2483:
2477:
2474:
2472:
2469:
2467:
2464:
2462:
2459:
2458:
2456:
2454:
2450:
2438:
2435:
2433:
2430:
2428:
2425:
2424:
2423:
2420:
2418:
2415:
2413:
2410:
2408:
2405:
2403:
2400:
2399:
2397:
2394:
2393:
2387:
2381:
2378:
2376:
2373:
2372:
2370:
2367:
2366:
2362:
2356:
2353:
2351:
2345:
2337:
2334:
2332:
2329:
2327:
2324:
2323:
2322:
2319:
2318:
2316:
2314:
2310:
2304:
2301:
2299:
2296:
2294:
2291:
2290:
2288:
2286:
2282:
2272:
2269:
2267:
2264:
2262:
2259:
2257:
2254:
2253:
2251:
2248:
2245:
2244:hormone-like:
2240:
2233:
2230:
2227:
2224:
2221:
2218:
2215:
2212:
2211:
2209:
2206:
2201:
2195:
2191:
2187:
2184:
2182:
2178:
2174:
2171:
2169:
2165:
2161:
2158:
2157:
2155:
2152:
2151:
2145:
2139:
2135:
2131:
2128:
2126:
2122:
2118:
2115:
2114:
2112:
2109:
2107:
2101:
2098:
2096:
2092:
2088:
2081:
2076:
2074:
2069:
2067:
2062:
2061:
2058:
2054:
2053:
2051:
2050:public domain
2047:
2038:
2034:
2033:
2028:
2027:
2022:
2019:
2015:
2012:
2011:
2007:
2000:
1996:
1991:
1986:
1982:
1978:
1974:
1970:
1966:
1961:
1957:
1953:
1949:
1945:
1941:
1937:
1933:
1929:
1924:
1920:
1916:
1912:
1908:
1904:
1900:
1895:
1894:
1889:
1881:
1877:
1872:
1867:
1863:
1859:
1858:J. Biol. Chem
1855:
1848:
1845:
1840:
1836:
1831:
1826:
1822:
1818:
1814:
1810:
1806:
1799:
1796:
1791:
1787:
1782:
1777:
1773:
1769:
1768:J. Biol. Chem
1765:
1758:
1755:
1750:
1746:
1742:
1738:
1734:
1730:
1723:
1720:
1715:
1711:
1707:
1703:
1699:
1698:10.1038/30666
1695:
1691:
1687:
1683:
1679:
1672:
1669:
1664:
1660:
1655:
1650:
1647:(1): 95–100.
1646:
1642:
1638:
1631:
1628:
1623:
1617:
1614:
1609:
1605:
1601:
1597:
1592:
1587:
1583:
1579:
1575:
1567:
1564:
1559:
1555:
1551:
1547:
1544:(2): 95–112.
1543:
1539:
1532:
1529:
1524:
1520:
1516:
1512:
1508:
1504:
1497:
1494:
1489:
1485:
1481:
1477:
1473:
1469:
1462:
1459:
1454:
1450:
1444:
1441:
1436:
1432:
1426:
1423:
1419:
1415:
1410:
1408:
1406:
1402:
1398:
1394:
1389:
1387:
1385:
1381:
1375:
1373:
1369:
1367:
1363:
1359:
1353:
1345:
1343:
1339:
1337:
1329:
1327:
1325:
1321:
1317:
1309:
1307:
1305:
1302:
1297:
1295:
1291:
1287:
1284:
1280:
1276:
1272:
1260:
1255:
1251:
1247:
1244:
1240:
1233:
1231:
1228:
1224:
1220:
1216:
1213:
1209:
1205:
1198:
1196:
1190:
1186:
1183:
1177:
1175:
1169:
1165:
1162:
1158:
1151:
1149:
1143:
1139:
1136:
1130:
1128:
1122:
1118:
1115:
1113:RefSeq (mRNA)
1111:
1104:
1103:
1098:
1094:
1091:
1085:
1084:
1079:
1075:
1072:
1070:
1066:
1059:
1058:
1053:
1049:
1046:
1040:
1039:
1034:
1030:
1027:
1025:
1021:
1014:
1013:
1008:
1004:
1001:
995:
994:
989:
985:
982:
980:
976:
973:
970:
968:
965:
961:
958:
954:
950:
943:
939:
934:
928:
925:
923:
920:
918:
915:
913:
910:
908:
905:
903:
900:
898:
895:
893:
890:
888:
885:
883:
880:
878:
875:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
713:
710:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
649:
647:
644:
643:
637:
634:
632:
629:
627:
624:
623:
621:
618:
617:
611:
608:
606:
603:
601:
598:
596:
593:
592:
590:
587:
586:
583:
582:Gene ontology
579:
575:
563:
558:
554:
549:
546:
544:
540:
532:
527:
516:
512:
508:
504:
500:
496:
492:
488:
484:
480:
479:
476:
472:
467:
464:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
417:
414:
410:
405:
402:
401:
398:
396:
392:
390:
389:
385:
384:
381:
379:
375:
371:
367:
363:
355:
350:
346:
342:
337:
327:
323:
316:
309:
303:
296:
288:
284:
280:
275:
271:
266:
262:
254:
249:
245:
241:
236:
226:
222:
215:
208:
202:
195:
191:
185:
181:
177:
172:
168:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
119:
111:
106:
99:
94:
89:
78:
76:
72:
68:
62:
57:
54:
53:
49:
46:
39:
35:
30:
26:
22:
17:
5478:Cerebrolysin
5474:
5448:Pleiotrophin
5404:Interleukins
5320:
5317:
5298:
5268:
5187:Fruquintinib
5177:Cabozantinib
5158:
5148:
5106:
5070:Lestaurtinib
5021:
5001:
4969:Lestaurtinib
4920:
4910:
4891:Antagonists:
4890:
4824:Deoxygedunin
4779:3,7,8,2'-THF
4770:
4749:
4740:Against NGF:
4739:
4736:
4692:Against NGF:
4691:
4684:
4681:
4644:Lestaurtinib
4595:
4585:
4579:Testosterone
4561:Antagonists:
4560:
4510:
4410:
4395:
4370:
4351:
4341:
4320:
4310:
4289:
4279:
4258:
4243:
4203:
4118:
4086:
4065:
4056:Against NGF:
4055:
4052:
4008:Against NGF:
4007:
4004:
3998:Testosterone
3980:Antagonists:
3979:
3929:
3899:
3860:
3835:
3824:
3801:Teprotumumab
3762:
3732:
3691:
3640:Ficlatuzumab
3635:Emibetuzumab
3631:
3585:JNJ-38877605
3555:Cabozantinib
3526:
3516:
3505:Fosgonimeton
3500:
3475:
3417:
3395:
3336:
3319:Infigratinib
3315:
3300:
3203:
3120:
3054:Betacellulin
3050:
3033:Seribantumab
3019:
2996:
2955:
2920:
2914:Unknown/none
2913:
2909:
2843:
2768:
2727:Betacellulin
2722:Amphiregulin
2717:
2709:(ErbB1/HER1)
2673:
2645:
2625:
2611:Antagonists:
2610:
2595:
2588:Angiopoietin
2390:
2359:
2348:Insulin/IGF/
2313:TGFβ pathway
2243:
2204:
2148:
2106:FGF receptor
2104:
2043:
2042:
2031:
2025:
1975:(1): 57–60.
1972:
1968:
1931:
1927:
1902:
1898:
1861:
1857:
1847:
1812:
1808:
1798:
1771:
1767:
1757:
1732:
1728:
1722:
1681:
1677:
1671:
1644:
1640:
1630:
1616:
1581:
1578:Hypertension
1577:
1566:
1541:
1537:
1531:
1509:(1): 75–80.
1506:
1502:
1496:
1474:(2): 551–5.
1471:
1467:
1461:
1452:
1443:
1434:
1425:
1370:
1355:
1340:
1333:
1313:
1300:
1298:
1278:
1274:
1270:
1269:
1192:
1171:
1145:
1124:
1100:
1081:
1055:
1036:
1010:
991:
971:
966:
817:human ageing
393:
386:
352:110,229,027
339:110,226,868
113:External IDs
64:
5438:Oncomodulin
5302:Aflibercept
5292:Ranibizumab
5287:Ramucirumab
5277:Bevacizumab
5269:Antibodies:
5227:Regorafenib
5167:Altiratinib
5080:ONO-5390556
5050:Entrectinib
5025:Altiratinib
4979:ONO-5390556
4949:Entrectinib
4924:Altiratinib
4710:Frunevetmab
4682:Antibodies:
4659:ONO-5390556
4624:Entrectinib
4599:Altiratinib
4554:Tavilermide
4449:Quizartinib
4388:SCF (c-Kit)
4212:Ramucirumab
4204:Antibodies:
4177:Quizartinib
4127:Avapritinib
4090:Becaplermin
4026:Frunevetmab
4005:Antibodies:
3908:Trofinetide
3839:Dusigitumab
3836:Antibodies:
3791:Robatumumab
3781:Figitumumab
3776:Dalotuzumab
3771:Cixutumumab
3763:Antibodies:
3655:Rilotumumab
3650:Onartuzumab
3645:Flanvotumab
3632:Antibodies:
3600:PF-04217903
3530:Altiratinib
3493:HGF (c-Met)
3396:Antibodies:
3301:Antibodies:
3023:Duligotumab
3020:Antibodies:
2934:Trastuzumab
2924:Ertumaxomab
2921:Antibodies:
2892:Zalutumumab
2887:Panitumumab
2882:Nimotuzumab
2877:Necitumumab
2867:Imgatuzumab
2844:Antibodies:
2827:Osimertinib
2792:Dacomitinib
2687:Dapiclermin
2646:Antibodies:
2629:Altiratinib
1928:Regul. Pept
1320:vasodilator
1283:vasodilator
439:human penis
427:pericardium
251:10,307,397
238:10,305,073
91:Identifiers
5494:Categories
5257:Vandetanib
5222:Rebastinib
5217:Pegaptanib
5207:Nintedanib
5197:Lenvatinib
5162:Agerafenib
5115:Ripretinib
5040:CH-7057288
4939:CH-7057288
4804:7,8,3'-THF
4799:7,8,2'-THF
4725:Ranevetmab
4715:Fulranumab
4669:Rebastinib
4614:CH-7057288
4529:Cenegermin
4414:Agerafenib
4374:Agerafenib
4355:Vandetanib
4324:Vandetanib
4293:Vandetanib
4262:Vandetanib
4207:Olaratumab
4182:Ripretinib
4162:Nintedanib
4147:Lenvatinib
4137:Crenolanib
4122:Agerafenib
4041:Ranevetmab
4031:Fulranumab
3948:Cenegermin
3922:LNGF (p75)
3844:Xentuzumab
3806:Xentuzumab
3751:NVP-AEW541
3746:NVP-ADW742
3741:Linsitinib
3736:BMS-754807
3721:Mecasermin
3620:Tivantinib
3610:PHA-665752
3605:PF-2341066
3575:Golvatinib
3565:Crizotinib
3560:Capmatinib
3550:BMS-777607
3545:Amuvatinib
3421:Ersofermin
3384:Sprifermin
3340:Ersofermin
3289:Sprifermin
3279:Repifermin
3274:Palifermin
3207:Ersofermin
3186:Velafermin
3171:Repifermin
3124:Ersofermin
3043:ErbB4/HER4
3028:Patritumab
2989:ErbB3/HER3
2969:Mubritinib
2929:Pertuzumab
2902:ErbB2/HER2
2832:Vandetanib
2787:Canertinib
2782:Brigatinib
2777:Agerafenib
2757:Nepidermin
2752:Murodermin
2742:Epiregulin
2697:EGF (ErbB)
2655:Nesvacumab
2649:Evinacumab
2639:Rebastinib
2580:modulators
2535:Hepatocyte
2095:Fibroblast
1420:, May 2017
1399:, May 2017
1376:References
455:glomerulus
397:(ortholog)
134:HomoloGene
5282:Icrucumab
5262:WHI-P 154
5252:Tivozanib
5247:Toceranib
5242:Sunitinib
5237:Sorafenib
5232:Semaxanib
5212:Pazopanib
5202:Motesanib
5192:Lapatinib
5182:Cediranib
5120:Telbermin
5107:Agonists:
5055:GZ-389988
5035:CE-245677
5002:Agonists:
4954:GZ-389988
4934:CE-245677
4834:Diosmetin
4771:Agonists:
4737:Aptamers:
4730:Tanezumab
4705:Fasinumab
4649:Milciclib
4629:GZ-389988
4609:CE-245677
4511:Agonists:
4464:Toceranib
4459:Sunitinib
4454:Sorafenib
4444:Pazopanib
4439:Nilotinib
4434:Masitinib
4424:Dasatinib
4396:Agonists:
4342:Agonists:
4311:Agonists:
4280:Agonists:
4252:Liatermin
4244:Agonists:
4227:RET (GFL)
4217:Tovetumab
4197:Toceranib
4192:Sorafenib
4187:Sunitinib
4172:Radotinib
4167:Pazopanib
4157:Motesanib
4152:Masitinib
4087:Agonists:
4053:Aptamers:
4046:Tanezumab
4021:Fasinumab
3930:Agonists:
3786:Ganitumab
3706:IGF-1 LR3
3625:Volitinib
3580:INCB28060
3570:Foretinib
3476:Agonists:
3460:Trafermin
3418:Agonists:
3399:Burosumab
3389:Trafermin
3337:Agonists:
3304:Aprutumab
3294:Trafermin
3256:10 (KGF2)
3204:Agonists:
3181:Trafermin
3161:10 (KGF2)
3121:Agonists:
3051:Agonists:
2997:Agonists:
2979:Tucatinib
2974:Neratinib
2964:Lapatinib
2872:Matuzumab
2862:Futuximab
2847:Cetuximab
2837:WHI-P 154
2822:Neratinib
2817:Lapatinib
2807:Grandinin
2802:Gefitinib
2797:Erlotinib
2674:Agonists:
2634:CE-245677
2596:Agonists:
1600:0194-911X
1346:Receptors
1195:NP_033757
1174:NP_001115
1148:NM_009627
1127:NM_001124
957:Orthologs
631:cytoplasm
423:beta cell
419:vena cava
142:GeneCards
5464:instead)
5453:Renalase
5414:instead)
5385:instead)
5332:instead)
5172:Axitinib
5141:D (FIGF)
5085:PLX-7486
5075:ONO-4474
5030:AZD-6918
4984:PLX-7486
4974:ONO-4474
4929:AZD-6918
4911:Ligands:
4829:Deprenyl
4789:7,3'-DHF
4720:MEDI-578
4700:ASP-6294
4664:PLX-7486
4654:ONO-4474
4604:AZD-6918
4564:ALE-0540
4485:instead.
4429:Imatinib
4419:Axitinib
4399:Ancestim
4364:Unsorted
4142:Imatinib
4132:Axitinib
4036:MEDI-578
4016:ASP-6294
3983:ALE-0540
3825:Agonists
3766:AVE-1642
3692:Agonists
3615:SU-11274
3501:Agonists
3479:FGF15/19
3469:Unsorted
3434:2 (bFGF)
3353:2 (bFGF)
3220:2 (bFGF)
3137:2 (bFGF)
2959:Afatinib
2910:Agonists
2812:Icotinib
2772:Afatinib
2718:Agonists
2247:FGF15/19
2108:ligands:
1956:21919410
1948:12686469
1919:14607083
1880:17470425
1839:21566080
1749:16111761
1608:23381795
1558:15670621
1523:15321737
1416:–
1395:–
1310:Function
1243:Wikidata
936:Sources:
493:gastrula
5341:Ephrins
5045:DS-6051
4944:DS-6051
4849:LM22A-4
4839:DMAQ-B1
4794:7,8-DHF
4774:3,7-DHF
4743:RBM-004
4688:GBR-900
4619:DS-6051
4589:VM-902A
4059:RBM-004
3756:OSl-906
3716:Insulin
3595:MK-2461
3540:AMG-458
2677:Axokine
2422:Relaxin
2361:Insulin
1999:9241097
1990:2042810
1830:3125095
1790:7592696
1714:4364526
1706:9620797
1686:Bibcode
1663:8989240
1488:9514956
1418:Ensembl
1397:Ensembl
1330:Peptide
1324:peptide
1316:hormone
1281:) is a
1069:UniProt
1024:Ensembl
963:Species
942:QuickGO
481:decidua
447:decidua
372:pattern
230:11p15.4
98:Aliases
5311:Others
5005:BNN-20
4894:ANA-12
4819:BNN-20
4539:DHEA-S
4524:BNN-27
4519:BNN-20
3958:DHEA-S
3943:BNN-27
3938:BNN-20
3854:Others
3059:Epigen
2737:Epigen
2509:VEGF-D
2504:VEGF-C
2499:VEGF-B
2494:VEGF-A
2303:HB-EGF
2234:(FHF4)
2228:(FHF2)
2222:(FHF1)
2216:(FHF3)
2023:Human
2020:(MeSH)
1997:
1987:
1954:
1946:
1917:
1878:
1837:
1827:
1788:
1747:
1712:
1704:
1678:Nature
1661:
1606:
1598:
1556:
1521:
1486:
1364:) 2 (
1358:CALCRL
1229:search
1227:PubMed
1102:P97297
1083:P35318
979:Entrez
543:BioGPS
505:atrium
130:108058
122:103275
5460:(see
5410:(see
5381:(see
5328:(see
5060:K252a
4959:K252a
4634:K252a
4574:FX007
4334:GFRα4
4303:GFRα3
4272:GFRα2
4236:GFRα1
3864:IGFBP
3817:IGF-2
3796:R1507
3684:IGF-1
3590:K252a
3410:FGFR4
3329:FGFR3
3196:FGFR2
3113:FGFR1
2530:Nerve
2523:Other
2476:PDGFD
2471:PDGFC
2466:PDGFB
2461:PDGFA
2417:INSL6
2412:INSL5
2407:INSL4
2402:INSL3
2336:TGFβ3
2331:TGFβ2
2326:TGFβ1
2271:FGF23
2266:FGF21
2261:FGF19
2256:FGF15
2232:FGF14
2226:FGF13
2220:FGF12
2214:FGF11
2194:FGF20
2190:FGF16
2181:FGF18
2177:FGF17
2168:FGF22
2164:FGF10
1952:S2CID
1710:S2CID
1366:RAMP2
1012:11535
972:Mouse
967:Human
938:Amigo
395:Mouse
388:Human
335:Start
270:Mouse
234:Start
167:Human
5462:here
5412:here
5383:here
5330:here
5125:VEGF
5099:VEGF
5015:NT-3
5010:DHEA
4994:TrkC
4914:DHEA
4884:TDP6
4864:NT-4
4859:NT-3
4844:HIOC
4814:BDNF
4763:TrkB
4534:DHEA
4503:TrkA
4483:here
4481:See
4474:TGFβ
4079:PDGF
3973:NT-4
3968:NT-3
3953:DHEA
3933:BDNF
2682:CNTF
2666:CNTF
2380:IGF2
2375:IGF1
2363:and
2321:TGFβ
2293:TGFα
2186:FGF9
2173:FGF8
2160:FGF7
2138:FGF6
2134:FGF4
2130:FGF3
2125:FGF5
2121:FGF2
2117:FGF1
1995:PMID
1944:PMID
1915:PMID
1876:PMID
1835:PMID
1786:PMID
1745:PMID
1702:PMID
1659:PMID
1604:PMID
1596:ISSN
1554:PMID
1519:PMID
1484:PMID
1304:gene
378:Bgee
326:Band
287:Chr.
225:Band
184:Chr.
118:OMIM
75:4RWF
71:2L7S
67:2FLY
48:RCSB
45:PDBe
4879:R13
4549:NGF
4494:Trk
3963:NGF
3675:IGF
3535:AM7
3426:FGF
3345:FGF
3246:),
3244:KGF
3212:FGF
3129:FGF
3104:FGF
2706:EGF
2514:PGF
2298:EGF
2150:KGF
2032:ADM
2026:ADM
1985:PMC
1977:doi
1936:doi
1932:113
1907:doi
1866:doi
1862:282
1825:PMC
1817:doi
1776:doi
1772:270
1737:doi
1733:109
1694:doi
1682:393
1649:doi
1586:doi
1546:doi
1542:105
1511:doi
1507:497
1476:doi
1472:244
1301:ADM
1277:or
1275:ADM
993:133
348:End
247:End
150:OMA
146:ADM
138:873
126:MGI
105:ADM
38:PDB
19:ADM
5496::
5373:B3
5371:,
5369:B2
5367:,
5365:B1
5363:,
5361:A5
5359:,
5357:A4
5355:,
5353:A3
5351:,
5349:A2
5347:,
5345:A1
5139:,
5135:,
5131:,
4874:R7
4690:;
4109:,
4105:,
4101:,
3890:,
3886:,
3882:,
3878:,
3874:,
3870:,
3827::
3694::
3503::
3454:19
3452:,
3448:,
3444:,
3440:,
3436:,
3432:,
3373:23
3371:,
3369:18
3367:,
3363:,
3359:,
3355:,
3351:,
3268:22
3266:,
3264:18
3262:,
3260:17
3258:,
3254:,
3250:,
3238:,
3234:,
3230:,
3226:,
3222:,
3218:,
3165:20
3163:,
3159:,
3155:,
3151:,
3147:,
3143:,
3139:,
3135:,
3087:,
3083:,
3079:,
3075:,
3010:,
3006:,
2912::
2720::
1993:.
1983:.
1973:44
1971:.
1967:.
1950:.
1942:.
1930:.
1913:.
1903:24
1901:.
1874:.
1860:.
1856:.
1833:.
1823:.
1813:25
1811:.
1807:.
1784:.
1770:.
1766:.
1743:.
1731:.
1708:.
1700:.
1692:.
1680:.
1657:.
1645:82
1643:.
1639:.
1602:.
1594:.
1582:61
1580:.
1576:.
1552:.
1540:.
1517:.
1505:.
1482:.
1470:.
1451:.
1433:.
1404:^
1383:^
1279:AM
940:/
354:bp
341:bp
253:bp
240:bp
148:;
144::
140:;
136::
132:;
128::
124:;
120::
73:,
69:,
5406:/
5375:)
5343:(
5143:)
5137:C
5133:B
5129:A
5127:(
4676:)
4113:)
4111:D
4107:C
4103:B
4099:A
4097:(
3894:)
3892:7
3888:6
3884:5
3880:4
3876:3
3872:2
3868:1
3866:(
3456:)
3450:9
3446:8
3442:6
3438:4
3430:1
3428:(
3375:)
3365:9
3361:8
3357:4
3349:1
3347:(
3270:)
3252:9
3248:8
3242:(
3240:7
3236:6
3232:5
3228:4
3224:3
3216:1
3214:(
3167:)
3157:8
3153:6
3149:5
3145:4
3141:3
3133:1
3131:(
3091:)
3085:4
3081:3
3077:2
3073:1
3071:(
3014:)
3008:2
3004:1
3002:(
2569:e
2562:t
2555:v
2437:3
2432:2
2427:1
2192:/
2188:/
2179:/
2175:/
2166:/
2162:/
2136:/
2132:/
2123:/
2119:/
2079:e
2072:t
2065:v
2052:.
2039:.
2001:.
1979::
1958:.
1938::
1921:.
1909::
1882:.
1868::
1841:.
1819::
1792:.
1778::
1751:.
1739::
1716:.
1696::
1688::
1665:.
1651::
1624:.
1610:.
1588::
1560:.
1548::
1525:.
1513::
1490:.
1478::
1455:.
1437:.
1273:(
272:)
169:)
152::
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