105:, DNA repair, and resistance to cancer, and he has had made important contributions in the characterization of pathways (such as TP53) involved in these critical cellular processes. He has been a pioneer in the use of genomic and metabolomic approaches to understand system-wide effects of damaging agents like radiation. In the case of metabolomics, Fornace is the founding director of the Waters Center of Innovation at Georgetown University in 2011, and the Center for Metabolomic Studies at Georgetown University Medical Center in 2019.
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Excellence in
Mentoring Award as well as the Failla Award of the Radiation Research Society, which is the annual career award to an outstanding member of the radiation research community in recognition of a history of major contributions to the field. In 2020, he was elected a Fellow in the National
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as model stress agents. These studies also have practical implications for health risks of radiation, assessment of radiation injury, as well as cancer treatment. Since 2010, he has directed a NASA Specialized Center of
Research to assess cancer risk during long-term space missions.
86:(DNA damaging) agents, such as radiation, that can cause cancer – as well as being used for its treatment. He was one of the first to show that human and other mammalian cells can respond at the gene level to genotoxic stress, and isolated many of the first known
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Kastan, M. B., Zhan, Q., el-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., and
Fornace, A. J., Jr. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71: 587-597,
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he received a variety of awards including the Public Health
Service Outstanding Service Medal. At Georgetown University he received the Medical Center Leadership in Research Award. In the radiation field he has received multiple awards including the
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Smith, M. L., Chen, I. T., Zhan, Q., Bae, I., Chen, C. Y., Gilmer, T. M., Kastan, M. B., O’Connor, P. M., and
Fornace, A. J., Jr. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 266: 1376-1380,
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Fornace, A. J., Jr, Nebert, D. W., Hollander, M. C., Luethy, J. D., Papathanasiou, M., Fargnoli, J., and
Holbrook, N. J. Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents. Mol Cell Biol 9: 4196-4203,
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Amundson, S. A., Bittner, M., Chen, Y., Trent, J., Meltzer, P., and
Fornace, A. J., Jr. Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses. Oncogene 18: 3666-3672,
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Fornace, A. J., Jr, Cummings, D. E., Comeau, C. M., Kant, J. A., and
Crabtree, G. R. Single-copy inverted repeats associated with regional genetic duplications in gamma fibrinogen and immunoglobulin genes. Science 224: 161-164,
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Bulavin, D. V., Higashimoto, Y., Popoff, I. J., Gaarde, W. A., Basrur, V., Potapova, O., Appella, E., and
Fornace, A. J., Jr. Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase. Nature 411: 102-107,
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Fornace, A. J., Jr, Kohn, K. W., and Kann, H. E. J. DNA single-strand breaks during repair of UV damage in human fibroblasts and abnormalities of repair in xeroderma pigmentosum. Proc Natl Acad Sci U S A 73: 39-43,
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Fornace has more than 410 publications with over 52,000 citations (Google
Scholar). He has mentored many research fellows and students who have gone on to successful scientific careers. While at the
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Coy, S. L., Cheema, A. K., Tyburski, J. B., Laiakis, E. C., Collins, S. P., and Fornace, A. J., jr. Radiation metabolomics and its potential in biodosimetry. Int J Radiat Biol 87: 802-823, 2011.
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Datta, K., Suman, S., Kallakury, B. V., and Fornace, A. J., Jr. Exposure to heavy ion radiation induces persistent oxidative stress in mouse intestine. PLoS One 7: e42224, 2012.
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Fornace, A. J., Jr, Alamo, I. J., and Hollander, M. C. DNA damage-inducible transcripts in mammalian cells. Proc Natl Acad Sci U S A 85: 8800-8804, 1988.
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Fornace, A. J., Jr. Mammalian genes induced by radiation; activation of genes associated with growth control. Annual Rev. Genetics 26: 507-526, 1992.
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132:’s laboratory, he elucidated a type of common regional genetic duplication event that occurs over an evolutionary time scale in humans.
22:(born 1949) is a professor in the departments of Oncology, Biochemistry and Molecular & Cellular Biology, and Radiation Medicine at
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Fornace, A. J., Jr. Recombination of parent and daughter strand DNA after UV-irradiation in mammalian cells. Nature 304: 552-554, 1983.
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Liebermann, D. A., & Hoffman, B. (2013). Gadd45 stress sensor genes. New York: Springer.
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His laboratory went on to show that many of these genes have roles in
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Mironova, N. Cancer and spaceflight. Aerospace America, 30-35, 2014
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Fornace has made a variety of notable discoveries in the fields of
26:. He has also been awarded the Molecular Cancer Research Chair at
46:(1967), and received his B.S. (1970) and M.D. (1972) from the
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339:Georgetown University Medical Center faculty
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305:. Retrieved July 14, 2017.
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