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99:. The proposed mechanism for this decrease in factor X is that circulating amyloid fibrils bind and inactivate factor X. Another contributing factor may be enhanced
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Amyloid purpura affects a minority of individuals with amyloidosis. For example, purpura is present early in the disease in approximately 15% of patients with
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The precise cause of amyloid purpura is unknown, but several mechanisms are thought to contribute. One may be a decrease in the level of circulating
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Amyloid purpura usually occurs above the nipple-line and is found in the webbing of the neck and in the face and eyelids.
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Kyle RA, Gertz MA (January 1995). "Primary systemic amyloidosis: clinical and laboratory features in 474 cases".
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Eder L, Bitterman H (June 2007). "Image in clinical medicine. Amyloid purpura".
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and lead to the extravasation of blood. Amyloid deposits in the
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may also play a role in the development of amyloid purpura.
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Gamba G, Montani N, Anesi E, et al. (March 2000).
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300:"Clotting alterations in primary systemic amyloidosis"
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Skin conditions resulting from errors in metabolism
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563:ACys+ABri/Cerebral amyloid angiopathy
517:ATTR/Transthyretin-related hereditary
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333:Amyloidosis, Immunoglobulin-Related
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586:AApoA1+AFib+ALys/Familial renal
512:AA/Familial Mediterranean fever
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632:ACal/Medullary thyroid cancer
604:Primary cutaneous amyloidosis
502:Aβ2M/Haemodialysis-associated
211:primary systemic amyloidosis
63:. Its cause is unknown, but
558:Familial amyloid neuropathy
71:are thought to contribute.
59:) in some individuals with
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527:Organ-limited amyloidosis
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109:Subendothelial deposits
568:Aβ/Alzheimer's disease
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117:gastrointestinal tract
111:of amyloid may weaken
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67:defects caused by
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644:APro/Prolactinoma
507:AGel/Finnish type
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53:Amyloid purpura
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205:Epidemiology
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186:adding to it
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147:adding to it
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101:fibrinolysis
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75:Presentation
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686:Amyloidosis
404:Amyloidosis
228:Amyloidosis
97:coagulation
65:coagulation
61:amyloidosis
46:Dermatology
680:Categories
234:References
639:Pituitary
619:Endocrine
338:eMedicine
166:Treatment
127:Diagnosis
42:Specialty
651:Pancreas
319:10702818
274:17554122
217:See also
89:factor X
627:Thyroid
413:amyloid
411:Common
363:7878478
223:Purpura
69:amyloid
57:purpura
36:Purpura
578:Kidney
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550:Brain
536:Heart
451:AIAPP
303:(PDF)
121:liver
105:clots
83:Cause
596:Skin
476:ABri
471:ACys
466:AANF
461:APro
456:ACal
432:Aβ2M
427:ATTR
359:PMID
315:PMID
270:PMID
119:and
91:, a
446:APP
336:at
262:doi
258:356
188:.
149:.
682::
442:Aβ
437:AL
422:AA
355:32
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